NUP85

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.47839982
2DNA unwinding involved in DNA replication (GO:0006268)5.41271776
3DNA strand elongation (GO:0022616)5.19858612
4DNA replication initiation (GO:0006270)5.19729462
5telomere maintenance via semi-conservative replication (GO:0032201)5.09083253
6protein localization to kinetochore (GO:0034501)4.95234549
7telomere maintenance via recombination (GO:0000722)4.55727196
8DNA replication checkpoint (GO:0000076)4.45040216
9nucleobase biosynthetic process (GO:0046112)4.40302761
10mitotic recombination (GO:0006312)4.39391180
11mitotic metaphase plate congression (GO:0007080)4.34588911
12IMP biosynthetic process (GO:0006188)4.23142656
13formation of translation preinitiation complex (GO:0001731)4.22778921
14DNA replication-dependent nucleosome organization (GO:0034723)4.22521431
15DNA replication-dependent nucleosome assembly (GO:0006335)4.22521431
16CENP-A containing nucleosome assembly (GO:0034080)4.19774897
17chromatin remodeling at centromere (GO:0031055)4.16937503
18folic acid-containing compound biosynthetic process (GO:0009396)4.15606949
19protein localization to chromosome, centromeric region (GO:0071459)4.13902060
20* mitotic nuclear envelope disassembly (GO:0007077)4.11386398
21maturation of SSU-rRNA (GO:0030490)4.10951087
22nuclear pore organization (GO:0006999)4.09039936
23purine nucleobase biosynthetic process (GO:0009113)4.06008422
24telomere maintenance via telomere lengthening (GO:0010833)4.05853743
25nucleotide-excision repair, DNA gap filling (GO:0006297)4.03214053
26mitotic chromosome condensation (GO:0007076)3.95641071
27metaphase plate congression (GO:0051310)3.90874235
28DNA replication-independent nucleosome organization (GO:0034724)3.87803739
29DNA replication-independent nucleosome assembly (GO:0006336)3.87803739
30mitotic sister chromatid segregation (GO:0000070)3.87167115
31ribosomal small subunit assembly (GO:0000028)3.82978412
32regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.82521522
33* membrane disassembly (GO:0030397)3.79098588
34* nuclear envelope disassembly (GO:0051081)3.79098588
35attachment of spindle microtubules to kinetochore (GO:0008608)3.77723148
36IMP metabolic process (GO:0046040)3.77196016
37kinetochore organization (GO:0051383)3.71411397
38nuclear pore complex assembly (GO:0051292)3.71242316
39proteasome assembly (GO:0043248)3.68583917
40establishment of viral latency (GO:0019043)3.66498570
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63538015
42DNA ligation (GO:0006266)3.63279054
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63010200
44ribosome biogenesis (GO:0042254)3.61949471
45DNA topological change (GO:0006265)3.59036385
46sister chromatid segregation (GO:0000819)3.57290636
47ribosome assembly (GO:0042255)3.57125783
48viral mRNA export from host cell nucleus (GO:0046784)3.55353679
49DNA duplex unwinding (GO:0032508)3.54955869
50DNA geometric change (GO:0032392)3.54624181
51establishment of chromosome localization (GO:0051303)3.53252656
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50719897
53histone exchange (GO:0043486)3.50615509
54ribosomal large subunit biogenesis (GO:0042273)3.49374113
55ribonucleoprotein complex biogenesis (GO:0022613)3.42991063
56regulation of spindle organization (GO:0090224)3.39926529
57pore complex assembly (GO:0046931)3.38832687
58negative regulation of ligase activity (GO:0051352)3.36990826
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36990826
60non-recombinational repair (GO:0000726)3.36410347
61double-strand break repair via nonhomologous end joining (GO:0006303)3.36410347
62DNA deamination (GO:0045006)3.35541781
63chromosome condensation (GO:0030261)3.35155990
64spliceosomal snRNP assembly (GO:0000387)3.33533060
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32344227
66meiotic chromosome segregation (GO:0045132)3.28909412
67viral transcription (GO:0019083)3.28586767
68regulation of mitochondrial translation (GO:0070129)3.26895499
69translational termination (GO:0006415)3.26854690
70kinetochore assembly (GO:0051382)3.25549369
71negative regulation of chromosome segregation (GO:0051985)3.24684961
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24418697
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.24418697
74chromosome segregation (GO:0007059)3.23559282
75chromatin assembly or disassembly (GO:0006333)3.23254469
76spindle checkpoint (GO:0031577)3.23198765
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20583919
78negative regulation of sister chromatid segregation (GO:0033046)3.20583919
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.20583919
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20583919
81rRNA processing (GO:0006364)3.19998349
82transcription-coupled nucleotide-excision repair (GO:0006283)3.18532194
83regulation of chromosome segregation (GO:0051983)3.18319176
84spindle assembly checkpoint (GO:0071173)3.17750447
85translational initiation (GO:0006413)3.17197414
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16287334
87telomere organization (GO:0032200)3.15817086
88telomere maintenance (GO:0000723)3.15790192
89mitotic spindle assembly checkpoint (GO:0007094)3.15155410
90positive regulation of chromosome segregation (GO:0051984)3.14865646
91heterochromatin organization (GO:0070828)3.13895455
92translational elongation (GO:0006414)3.12809794
93mismatch repair (GO:0006298)3.12750591
94rRNA metabolic process (GO:0016072)3.09715015
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08818567
96DNA packaging (GO:0006323)3.08804428
97mitotic spindle checkpoint (GO:0071174)3.08704814
98regulation of centrosome cycle (GO:0046605)3.08507200
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07920451
100nucleobase-containing small molecule interconversion (GO:0015949)3.07915343
101ribosomal small subunit biogenesis (GO:0042274)3.07650454
102regulation of centriole replication (GO:0046599)3.07269443
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.06306739
104protein localization to chromosome (GO:0034502)3.06036933
105regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05706945
106G1/S transition of mitotic cell cycle (GO:0000082)3.04388164
107cell cycle G1/S phase transition (GO:0044843)3.04388164
108DNA synthesis involved in DNA repair (GO:0000731)3.04100057
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02724970
110establishment of integrated proviral latency (GO:0075713)3.01463608
111DNA conformation change (GO:0071103)3.01305219
112translesion synthesis (GO:0019985)3.01016579
113protein K6-linked ubiquitination (GO:0085020)2.99448758
114ATP-dependent chromatin remodeling (GO:0043044)2.99127741
115* mitotic cell cycle (GO:0000278)2.98903316
116mitotic sister chromatid cohesion (GO:0007064)2.97639218
117regulation of helicase activity (GO:0051095)2.96721611
118postreplication repair (GO:0006301)2.96130787
119spliceosomal complex assembly (GO:0000245)2.95652653
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95424025
121nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95095875
122* nuclear envelope organization (GO:0006998)2.93412252
123base-excision repair (GO:0006284)2.93042601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.78594302
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.46154189
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.33963440
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95611774
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77619516
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.33757800
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04233420
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96947593
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86663535
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82771000
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.80010051
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.67031694
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63769489
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.56427216
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50980775
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40551436
17XRN2_22483619_ChIP-Seq_HELA_Human2.39448394
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37157513
19AR_21909140_ChIP-Seq_LNCAP_Human2.36001747
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.16260780
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11157736
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10567464
23* VDR_23849224_ChIP-Seq_CD4+_Human2.08608299
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.03210632
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99197106
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98803886
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98465543
28* DCP1A_22483619_ChIP-Seq_HELA_Human1.97356113
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91613360
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.91131272
31* GABP_19822575_ChIP-Seq_HepG2_Human1.85859151
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85085297
33TTF2_22483619_ChIP-Seq_HELA_Human1.84573612
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83479129
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77417636
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76597156
37CIITA_25753668_ChIP-Seq_RAJI_Human1.74588661
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73102983
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71367668
40MYC_22102868_ChIP-Seq_BL_Human1.64403268
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63145881
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61786773
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59660484
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56836811
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52394676
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50398179
47KDM5A_27292631_Chip-Seq_BREAST_Human1.48502807
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.46258975
49ELK1_19687146_ChIP-ChIP_HELA_Human1.46208639
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43763405
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43027540
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39584065
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39049691
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36359344
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35305686
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28848433
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28448762
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26103167
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.25672136
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23950770
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22873931
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22777464
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22410358
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18562796
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18481605
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17730593
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17722090
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17041394
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.13756554
70TFEB_21752829_ChIP-Seq_HELA_Human1.11141282
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11028163
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10157945
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09741900
74* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09256788
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08766717
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07369737
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06517840
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03756530
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02793865
80MYC_18940864_ChIP-ChIP_HL60_Human0.99839959
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99637297
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99327326
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98639801
84VDR_21846776_ChIP-Seq_THP-1_Human0.97725971
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95597103
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95438039
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93129848
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92893219
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.92766566
90* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87089622
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86893967
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86541767
93* NANOG_21062744_ChIP-ChIP_HESCs_Human0.84243451
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83759397
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83573123
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82530358
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81326720
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.80956071
99ZNF263_19887448_ChIP-Seq_K562_Human0.80905223
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78974933
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78352194
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77916318
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77772721
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76193723
105FOXP1_21924763_ChIP-Seq_HESCs_Human0.75685138
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74836456
107OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74223747
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73979327
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73736050
110SPI1_23547873_ChIP-Seq_NB4_Human0.73305551
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.72327811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.62664878
2MP0010094_abnormal_chromosome_stability5.24603839
3MP0003111_abnormal_nucleus_morphology4.91934192
4MP0004957_abnormal_blastocyst_morpholog4.66004207
5MP0008057_abnormal_DNA_replication4.42063694
6MP0003077_abnormal_cell_cycle4.30261657
7MP0008058_abnormal_DNA_repair3.50141784
8MP0008007_abnormal_cellular_replicative2.98706617
9MP0008932_abnormal_embryonic_tissue2.82315436
10MP0003123_paternal_imprinting2.69591735
11MP0001730_embryonic_growth_arrest2.60223003
12MP0010352_gastrointestinal_tract_polyps2.56643040
13MP0000350_abnormal_cell_proliferation2.45224299
14MP0002396_abnormal_hematopoietic_system2.44293907
15MP0008877_abnormal_DNA_methylation2.06675815
16MP0010307_abnormal_tumor_latency2.06453759
17MP0003786_premature_aging1.91426997
18MP0001672_abnormal_embryogenesis/_devel1.84299233
19MP0005380_embryogenesis_phenotype1.84299233
20MP0001697_abnormal_embryo_size1.84100002
21MP0006035_abnormal_mitochondrial_morpho1.74822537
22MP0002080_prenatal_lethality1.73443321
23MP0000490_abnormal_crypts_of1.70773592
24MP0003718_maternal_effect1.68702793
25MP0002085_abnormal_embryonic_tissue1.63235973
26MP0003984_embryonic_growth_retardation1.62722380
27MP0002088_abnormal_embryonic_growth/wei1.58894086
28MP0000313_abnormal_cell_death1.53201860
29MP0001346_abnormal_lacrimal_gland1.52218635
30MP0002019_abnormal_tumor_incidence1.51272513
31MP0004808_abnormal_hematopoietic_stem1.50345819
32MP0002084_abnormal_developmental_patter1.49531020
33MP0003121_genomic_imprinting1.48615446
34MP0002086_abnormal_extraembryonic_tissu1.45625399
35MP0003806_abnormal_nucleotide_metabolis1.44855014
36MP0004197_abnormal_fetal_growth/weight/1.40954983
37MP0010030_abnormal_orbit_morphology1.40097265
38MP0003567_abnormal_fetal_cardiomyocyte1.34887907
39MP0003890_abnormal_embryonic-extraembry1.34300412
40MP0002210_abnormal_sex_determination1.27134980
41MP0008995_early_reproductive_senescence1.22876258
42MP0008260_abnormal_autophagy1.20151779
43MP0001293_anophthalmia1.19791463
44MP0009333_abnormal_splenocyte_physiolog1.13845909
45MP0000372_irregular_coat_pigmentation1.13177878
46MP0001545_abnormal_hematopoietic_system1.12970138
47MP0005397_hematopoietic_system_phenotyp1.12970138
48MP0000703_abnormal_thymus_morphology1.12396340
49MP0006054_spinal_hemorrhage1.11039458
50MP0003763_abnormal_thymus_physiology1.10782471
51MP0001145_abnormal_male_reproductive1.09666733
52MP0005076_abnormal_cell_differentiation1.06013571
53MP0006292_abnormal_olfactory_placode0.99355722
54MP0001929_abnormal_gametogenesis0.97556775
55MP0002160_abnormal_reproductive_system0.97393861
56MP0002398_abnormal_bone_marrow0.97267938
57MP0001764_abnormal_homeostasis0.96841019
58MP0002877_abnormal_melanocyte_morpholog0.96718765
59MP0000653_abnormal_sex_gland0.95025920
60MP0002722_abnormal_immune_system0.93304052
61MP0000537_abnormal_urethra_morphology0.92858511
62MP0002653_abnormal_ependyma_morphology0.91866565
63MP0005501_abnormal_skin_physiology0.91374137
64MP0003315_abnormal_perineum_morphology0.91364937
65MP0003119_abnormal_digestive_system0.90504270
66MP0000358_abnormal_cell_content/0.88638322
67MP0005083_abnormal_biliary_tract0.87494798
68MP0003221_abnormal_cardiomyocyte_apopto0.86344608
69MP0003705_abnormal_hypodermis_morpholog0.85856113
70MP0001661_extended_life_span0.85664150
71MP0001119_abnormal_female_reproductive0.85348972
72MP0009672_abnormal_birth_weight0.84225411
73MP0002697_abnormal_eye_size0.83991232
74MP0000689_abnormal_spleen_morphology0.83754406
75MP0000858_altered_metastatic_potential0.83730874
76MP0005384_cellular_phenotype0.83633467
77MP0001853_heart_inflammation0.82934408
78MP0003698_abnormal_male_reproductive0.81042758
79MP0004185_abnormal_adipocyte_glucose0.80904605
80MP0004133_heterotaxia0.79959681
81MP0008789_abnormal_olfactory_epithelium0.79201893
82MP0005389_reproductive_system_phenotype0.79079175
83MP0005621_abnormal_cell_physiology0.78580921
84MP0009278_abnormal_bone_marrow0.77226432
85MP0001915_intracranial_hemorrhage0.76889546
86MP0004147_increased_porphyrin_level0.76315417
87MP0003943_abnormal_hepatobiliary_system0.76196319
88MP0002163_abnormal_gland_morphology0.75730626
89MP0002429_abnormal_blood_cell0.75608223
90MP0005023_abnormal_wound_healing0.74450752
91MP0002111_abnormal_tail_morphology0.74133688
92MP0003937_abnormal_limbs/digits/tail_de0.72945733
93MP0002161_abnormal_fertility/fecundity0.72071877
94MP0000566_synostosis0.71280207
95MP0009053_abnormal_anal_canal0.66405902
96MP0002970_abnormal_white_adipose0.64773745
97MP0009703_decreased_birth_body0.64742123
98MP0005075_abnormal_melanosome_morpholog0.62457651
99MP0002132_abnormal_respiratory_system0.60692096
100MP0005266_abnormal_metabolism0.60627525
101MP0000015_abnormal_ear_pigmentation0.60349461
102MP0000477_abnormal_intestine_morphology0.59113794
103MP0002092_abnormal_eye_morphology0.58548787
104MP0001727_abnormal_embryo_implantation0.58105226
105MP0000428_abnormal_craniofacial_morphol0.57746387
106MP0004264_abnormal_extraembryonic_tissu0.57277267
107MP0003699_abnormal_female_reproductive0.57275674
108MP0005499_abnormal_olfactory_system0.57033246
109MP0005394_taste/olfaction_phenotype0.57033246
110MP0005395_other_phenotype0.57012336
111MP0001919_abnormal_reproductive_system0.56983660
112MP0002938_white_spotting0.56425514
113MP0009697_abnormal_copulation0.55785749
114MP0003186_abnormal_redox_activity0.54743624
115MP0006036_abnormal_mitochondrial_physio0.54254318
116MP0003566_abnormal_cell_adhesion0.54239558
117MP0000716_abnormal_immune_system0.53832035
118MP0001286_abnormal_eye_development0.53392153
119MP0000678_abnormal_parathyroid_gland0.53038780
120MP0004233_abnormal_muscle_weight0.52904491
121MP0000647_abnormal_sebaceous_gland0.52535751
122MP0003941_abnormal_skin_development0.51643794
123MP0002075_abnormal_coat/hair_pigmentati0.51598816
124MP0001216_abnormal_epidermal_layer0.51377667
125MP0002095_abnormal_skin_pigmentation0.51201355
126MP0001881_abnormal_mammary_gland0.50850743
127MP0001873_stomach_inflammation0.49611970
128MP0002269_muscular_atrophy0.49217947
129MP0008770_decreased_survivor_rate0.48887032
130MP0003115_abnormal_respiratory_system0.48860458
131MP0001849_ear_inflammation0.48503238

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.35889033
2Microvesicular hepatic steatosis (HP:0001414)4.52099740
3Reticulocytopenia (HP:0001896)4.35354922
4Chromsome breakage (HP:0040012)4.32991218
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.19038379
6Breast hypoplasia (HP:0003187)4.08988349
7Colon cancer (HP:0003003)4.04866943
8Ependymoma (HP:0002888)3.81218861
9Selective tooth agenesis (HP:0001592)3.72450926
10Abnormality of cells of the erythroid lineage (HP:0012130)3.65405087
11Oral leukoplakia (HP:0002745)3.65081877
12Medulloblastoma (HP:0002885)3.61731355
13Abnormal number of erythroid precursors (HP:0012131)3.49204221
14Abnormality of chromosome stability (HP:0003220)3.39630770
15Patellar aplasia (HP:0006443)3.39597700
16Meckel diverticulum (HP:0002245)3.37707602
17Abnormality of the preputium (HP:0100587)3.32410872
18Abnormality of the ileum (HP:0001549)3.25099476
19Aplasia/Hypoplasia of the patella (HP:0006498)3.19429479
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.18177272
21Abnormality of the anterior horn cell (HP:0006802)3.06639465
22Degeneration of anterior horn cells (HP:0002398)3.06639465
23Duodenal stenosis (HP:0100867)2.95740430
24Small intestinal stenosis (HP:0012848)2.95740430
25Agnosia (HP:0010524)2.94869837
26Rhabdomyosarcoma (HP:0002859)2.92777358
27Progressive muscle weakness (HP:0003323)2.86955417
28Cerebral hypomyelination (HP:0006808)2.84427007
29Myelodysplasia (HP:0002863)2.82764358
30Absent thumb (HP:0009777)2.82319004
31Rough bone trabeculation (HP:0100670)2.80612509
32Aplastic anemia (HP:0001915)2.75449075
33Carpal bone hypoplasia (HP:0001498)2.67454600
34Neoplasm of the pancreas (HP:0002894)2.64013495
35Microretrognathia (HP:0000308)2.63265627
36Absent radius (HP:0003974)2.61845834
37Bone marrow hypocellularity (HP:0005528)2.59958837
38Abnormal mitochondria in muscle tissue (HP:0008316)2.57174725
39Pallor (HP:0000980)2.56579619
40Astrocytoma (HP:0009592)2.53246915
41Abnormality of the astrocytes (HP:0100707)2.53246915
42Acute necrotizing encephalopathy (HP:0006965)2.51148160
43Abnormality of the labia minora (HP:0012880)2.49568704
44Impulsivity (HP:0100710)2.49470236
45Abnormality of glycolysis (HP:0004366)2.47594513
46Premature graying of hair (HP:0002216)2.46862826
47Type I transferrin isoform profile (HP:0003642)2.46043880
48Acute encephalopathy (HP:0006846)2.46039496
49Ectopic kidney (HP:0000086)2.44563208
50Absent forearm bone (HP:0003953)2.44102571
51Aplasia involving forearm bones (HP:0009822)2.44102571
52Abnormal lung lobation (HP:0002101)2.44027857
53Increased CSF lactate (HP:0002490)2.43926308
54Abnormality of the duodenum (HP:0002246)2.42750374
55Hypoplastic pelvis (HP:0008839)2.42198053
56Increased serum pyruvate (HP:0003542)2.41458633
57Macrocytic anemia (HP:0001972)2.40790015
58Abnormal number of incisors (HP:0011064)2.39909896
59Sloping forehead (HP:0000340)2.39822360
60Increased serum lactate (HP:0002151)2.39520878
61Glioma (HP:0009733)2.39275765
62Basal cell carcinoma (HP:0002671)2.38991438
6311 pairs of ribs (HP:0000878)2.38794398
64Duplicated collecting system (HP:0000081)2.37531028
65Atresia of the external auditory canal (HP:0000413)2.36012081
66Broad distal phalanx of finger (HP:0009836)2.32575949
67Poikiloderma (HP:0001029)2.31645493
68Tracheoesophageal fistula (HP:0002575)2.29752082
69Entropion (HP:0000621)2.27915453
70Increased nuchal translucency (HP:0010880)2.27509908
71Horseshoe kidney (HP:0000085)2.26628834
72Increased hepatocellular lipid droplets (HP:0006565)2.25251693
73Neoplasm of striated muscle (HP:0009728)2.24378329
74Ragged-red muscle fibers (HP:0003200)2.23495805
75Premature ovarian failure (HP:0008209)2.23309231
76Abnormality of the carotid arteries (HP:0005344)2.22309740
77Cellular immunodeficiency (HP:0005374)2.22304295
78Cafe-au-lait spot (HP:0000957)2.21930789
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21626620
80Hepatocellular necrosis (HP:0001404)2.20692542
81Mitochondrial inheritance (HP:0001427)2.18903027
82Cerebral edema (HP:0002181)2.17059109
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16231755
84Abnormal protein N-linked glycosylation (HP:0012347)2.16231755
85Abnormal protein glycosylation (HP:0012346)2.16231755
86Abnormal glycosylation (HP:0012345)2.16231755
87Proximal placement of thumb (HP:0009623)2.16039771
88Trismus (HP:0000211)2.14305606
89High pitched voice (HP:0001620)2.13331921
90Supernumerary spleens (HP:0009799)2.12237838
91Neoplasm of the oral cavity (HP:0100649)2.12025981
92Abnormality of reticulocytes (HP:0004312)2.11590828
93Squamous cell carcinoma (HP:0002860)2.09986200
94Deviation of the thumb (HP:0009603)2.09335577
95Choanal atresia (HP:0000453)2.08753906
96Thrombocytosis (HP:0001894)2.07455313
97Triphalangeal thumb (HP:0001199)2.07088887
98Lipid accumulation in hepatocytes (HP:0006561)2.06019338
99Slender long bone (HP:0003100)2.05638850
100Respiratory difficulties (HP:0002880)2.04805694
101Facial cleft (HP:0002006)2.04497652
102Abnormality of the renal collecting system (HP:0004742)2.04421315
103Amaurosis fugax (HP:0100576)2.03956651
104Abnormality of the heme biosynthetic pathway (HP:0010472)2.03241809
105Embryonal renal neoplasm (HP:0011794)2.02620276
106Short thumb (HP:0009778)2.00782445
107Neoplasm of the colon (HP:0100273)1.99567488
108Testicular atrophy (HP:0000029)1.97645053
109Abnormal trabecular bone morphology (HP:0100671)1.96213141
110Abnormality of pyrimidine metabolism (HP:0004353)1.95770142
111Progressive external ophthalmoplegia (HP:0000590)1.95674597
112Arteriovenous malformation (HP:0100026)1.95484042
113Secondary amenorrhea (HP:0000869)1.95320917
114Prominent nose (HP:0000448)1.94203599
115Abnormality of the calcaneus (HP:0008364)1.93386233
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.93165921
117Abnormality of DNA repair (HP:0003254)1.92526392
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91471690
119Clubbing of toes (HP:0100760)1.91260357
120Multiple enchondromatosis (HP:0005701)1.90858218
121Lymphoma (HP:0002665)1.89987300
122Hepatic necrosis (HP:0002605)1.88872921
123Pancytopenia (HP:0001876)1.88682718
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88329761
125Missing ribs (HP:0000921)1.87650591
126Asplenia (HP:0001746)1.87647612
127Lactic acidosis (HP:0003128)1.86823683
128Nephroblastoma (Wilms tumor) (HP:0002667)1.85598173
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.83572575
130Cleft eyelid (HP:0000625)1.80871265
131Hypergonadotropic hypogonadism (HP:0000815)1.79892324
132Reduced antithrombin III activity (HP:0001976)1.78057906
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77013847
134Short 4th metacarpal (HP:0010044)1.77013847
135Volvulus (HP:0002580)1.76653113
136Exercise intolerance (HP:0003546)1.76476060
137Abnormal gallbladder physiology (HP:0012438)1.75313374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.83190301
2BUB14.65001951
3WEE14.32779179
4VRK23.76009329
5EIF2AK13.05229451
6NEK22.98003093
7NEK12.73573599
8TTK2.66328282
9TSSK62.58589515
10SRPK12.28400676
11PLK12.16610114
12ACVR1B2.13960798
13BRSK22.11901330
14PLK42.06491167
15PASK2.02273333
16SMG11.92212941
17ATR1.87212934
18CDK71.85537881
19NME21.85008373
20TLK11.83900189
21VRK11.77698881
22AURKB1.75711180
23MKNK11.71997029
24TESK21.69056704
25EEF2K1.67996841
26CCNB11.66107617
27MST1R1.64578811
28PLK31.63160404
29RPS6KB21.60424295
30BRSK11.59485850
31MAP3K81.56568780
32DYRK31.56011304
33STK161.54748362
34CHEK21.50398044
35CDK121.49849793
36RPS6KA41.49409375
37CDK41.45876494
38STK101.43043004
39PDK21.40994736
40EIF2AK31.37670612
41AURKA1.34538831
42SCYL21.31508046
43CHEK11.30525956
44IRAK31.29189443
45TGFBR11.27449749
46MST41.13205044
47MKNK21.11635404
48PAK41.10131743
49PKN21.05834106
50MAP3K101.04031067
51EPHA21.02442025
52STK41.01853850
53CDK81.01550666
54ZAK0.95232540
55ATM0.92910656
56CDK20.89982573
57TAF10.85407487
58BRAF0.82123121
59FLT30.79721318
60MELK0.79363561
61PIM10.77700981
62ALK0.76753158
63PAK10.73480194
64NUAK10.73048528
65PRKCI0.72207566
66BCKDK0.69213202
67CSNK2A20.68870568
68CDK10.68634647
69CDK60.64715587
70LRRK20.64294606
71CSNK2A10.63888945
72MAP4K10.62854267
73BRD40.62463471
74TRIM280.60561164
75CSNK1G30.57035635
76MAP2K30.56083833
77KDR0.54551669
78ICK0.53897605
79TESK10.51742169
80EIF2AK20.49217841
81CLK10.47531950
82MAP3K110.45814874
83RPS6KA50.45216291
84PIM20.44834705
85CDK90.43793508
86CSNK1A1L0.41350546
87STK30.40871304
88MET0.39517905
89TRIB30.38956349
90PRKDC0.38548068
91TAOK20.38135346
92CSNK1G10.38035287
93CSNK1E0.37979437
94ERBB40.37845809
95MTOR0.36932905
96AKT20.35106190
97MAPKAPK30.33243398
98PNCK0.32076506
99BTK0.31991997
100ILK0.31091979
101DAPK10.29751580
102GRK60.29591836
103MARK30.27500342
104MAPK110.24066525
105BMX0.22926287
106RAF10.22205018
107MAPK140.21707081
108PAK20.21568653
109NME10.21270891
110DYRK20.20794466
111CDK180.20613232
112CSNK1D0.20084980
113FGFR10.18544016
114AKT10.18503980
115SIK30.17839304
116CDK11A0.17687749
117BMPR1B0.17123762
118PBK0.14598828
119RPS6KB10.14081687
120MAPKAPK20.14077301
121CDK140.14050427
122CDK150.13523651
123LATS20.13396464
124RPS6KA10.13058671

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.68599378
2Mismatch repair_Homo sapiens_hsa034304.82171130
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.59444942
4Base excision repair_Homo sapiens_hsa034103.33776974
5Spliceosome_Homo sapiens_hsa030403.29934288
6Homologous recombination_Homo sapiens_hsa034403.19021659
7* RNA transport_Homo sapiens_hsa030133.14690220
8Nucleotide excision repair_Homo sapiens_hsa034203.08069374
9Ribosome_Homo sapiens_hsa030103.05848233
10Proteasome_Homo sapiens_hsa030502.99662998
11Cell cycle_Homo sapiens_hsa041102.98545418
12RNA polymerase_Homo sapiens_hsa030202.87973631
13One carbon pool by folate_Homo sapiens_hsa006702.86118676
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71980081
15Pyrimidine metabolism_Homo sapiens_hsa002402.40384644
16Fanconi anemia pathway_Homo sapiens_hsa034602.37947675
17Non-homologous end-joining_Homo sapiens_hsa034502.13974424
18RNA degradation_Homo sapiens_hsa030181.97607386
19mRNA surveillance pathway_Homo sapiens_hsa030151.77879309
20Basal transcription factors_Homo sapiens_hsa030221.73401389
21p53 signaling pathway_Homo sapiens_hsa041151.59781325
22Purine metabolism_Homo sapiens_hsa002301.28787856
23Systemic lupus erythematosus_Homo sapiens_hsa053221.18075900
24Oxidative phosphorylation_Homo sapiens_hsa001901.17204402
25Epstein-Barr virus infection_Homo sapiens_hsa051691.13105849
26Oocyte meiosis_Homo sapiens_hsa041141.10502336
27Pyruvate metabolism_Homo sapiens_hsa006201.05395996
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05096719
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01173935
30Biosynthesis of amino acids_Homo sapiens_hsa012301.00527429
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98745012
32Viral carcinogenesis_Homo sapiens_hsa052030.97689567
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.95152850
34Fatty acid elongation_Homo sapiens_hsa000620.92173858
35Herpes simplex infection_Homo sapiens_hsa051680.90702967
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.89633745
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88869612
38Antigen processing and presentation_Homo sapiens_hsa046120.87358226
39Selenocompound metabolism_Homo sapiens_hsa004500.84520494
40HTLV-I infection_Homo sapiens_hsa051660.79179834
41Folate biosynthesis_Homo sapiens_hsa007900.78311387
42Pentose phosphate pathway_Homo sapiens_hsa000300.77449484
43Steroid biosynthesis_Homo sapiens_hsa001000.68923273
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.66963626
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64073092
46Vitamin B6 metabolism_Homo sapiens_hsa007500.60294317
47MicroRNAs in cancer_Homo sapiens_hsa052060.59725912
48Propanoate metabolism_Homo sapiens_hsa006400.57384870
49Lysine degradation_Homo sapiens_hsa003100.57204142
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56436155
51Alzheimers disease_Homo sapiens_hsa050100.55855825
52Small cell lung cancer_Homo sapiens_hsa052220.55285490
53Thyroid cancer_Homo sapiens_hsa052160.55016090
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53011867
55Legionellosis_Homo sapiens_hsa051340.52671802
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52573283
57Carbon metabolism_Homo sapiens_hsa012000.51787695
58Sulfur relay system_Homo sapiens_hsa041220.51240105
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48855294
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47924909
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44815147
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44655024
63Alcoholism_Homo sapiens_hsa050340.44056844
64Primary immunodeficiency_Homo sapiens_hsa053400.42481409
65Apoptosis_Homo sapiens_hsa042100.41946481
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41303023
67Colorectal cancer_Homo sapiens_hsa052100.41190011
68Glutathione metabolism_Homo sapiens_hsa004800.40626807
69Protein export_Homo sapiens_hsa030600.39536060
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39415557
71Hippo signaling pathway_Homo sapiens_hsa043900.38381436
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37545706
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37497311
74N-Glycan biosynthesis_Homo sapiens_hsa005100.36884929
75Huntingtons disease_Homo sapiens_hsa050160.35862154
76Bladder cancer_Homo sapiens_hsa052190.34120440
77TGF-beta signaling pathway_Homo sapiens_hsa043500.33914665
78Fatty acid metabolism_Homo sapiens_hsa012120.32007618
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31858576
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31588917
81Fructose and mannose metabolism_Homo sapiens_hsa000510.31434223
82Basal cell carcinoma_Homo sapiens_hsa052170.31332108
83Hepatitis B_Homo sapiens_hsa051610.31291534
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30794631
85Chronic myeloid leukemia_Homo sapiens_hsa052200.30081145
86Measles_Homo sapiens_hsa051620.25101861
87Notch signaling pathway_Homo sapiens_hsa043300.24947345
88Shigellosis_Homo sapiens_hsa051310.24675528
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24505931
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.24384724
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23682019
92Other glycan degradation_Homo sapiens_hsa005110.22528731
93HIF-1 signaling pathway_Homo sapiens_hsa040660.21790732
94Pathways in cancer_Homo sapiens_hsa052000.20147522
95Viral myocarditis_Homo sapiens_hsa054160.18431874
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17928601
97Influenza A_Homo sapiens_hsa051640.17272431
98Galactose metabolism_Homo sapiens_hsa000520.17199155
99Metabolic pathways_Homo sapiens_hsa011000.14131163
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.13674438
101Parkinsons disease_Homo sapiens_hsa050120.12599137
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.12593599
103Acute myeloid leukemia_Homo sapiens_hsa052210.12200304
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12008634
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11681796
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11663397
107mTOR signaling pathway_Homo sapiens_hsa041500.11020593
108Hedgehog signaling pathway_Homo sapiens_hsa043400.09080755
109Non-small cell lung cancer_Homo sapiens_hsa052230.08825804
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08693473
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.08203254
112Pancreatic cancer_Homo sapiens_hsa052120.07864896
113Arginine and proline metabolism_Homo sapiens_hsa003300.06138227
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05898504
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05799071
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05270586
117Peroxisome_Homo sapiens_hsa041460.05078609
118Adherens junction_Homo sapiens_hsa045200.04874924
119Prostate cancer_Homo sapiens_hsa052150.03128153
120Melanoma_Homo sapiens_hsa052180.02932953
121Vitamin digestion and absorption_Homo sapiens_hsa049770.01863576

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