NUP88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.83961600
2nuclear pore complex assembly (GO:0051292)4.66096269
3DNA unwinding involved in DNA replication (GO:0006268)4.35951020
4mitotic metaphase plate congression (GO:0007080)4.25470911
5DNA strand elongation involved in DNA replication (GO:0006271)4.20642561
6DNA replication-dependent nucleosome organization (GO:0034723)4.17479978
7DNA replication-dependent nucleosome assembly (GO:0006335)4.17479978
8DNA replication initiation (GO:0006270)4.17194609
9* mitotic nuclear envelope disassembly (GO:0007077)4.14766863
10DNA strand elongation (GO:0022616)4.02496869
11telomere maintenance via semi-conservative replication (GO:0032201)4.01650090
12protein localization to kinetochore (GO:0034501)4.00404673
13metaphase plate congression (GO:0051310)3.98471139
14establishment of integrated proviral latency (GO:0075713)3.90716802
15meiotic chromosome segregation (GO:0045132)3.85858826
16* membrane disassembly (GO:0030397)3.84089927
17* nuclear envelope disassembly (GO:0051081)3.84089927
18attachment of spindle microtubules to kinetochore (GO:0008608)3.83605425
19DNA ligation (GO:0006266)3.80239999
20mitotic chromosome condensation (GO:0007076)3.80190689
21chromatin remodeling at centromere (GO:0031055)3.79932259
22telomere maintenance via recombination (GO:0000722)3.79721073
23mitotic recombination (GO:0006312)3.77966798
24CENP-A containing nucleosome assembly (GO:0034080)3.73451576
25mitotic sister chromatid segregation (GO:0000070)3.66163657
26non-recombinational repair (GO:0000726)3.64236884
27double-strand break repair via nonhomologous end joining (GO:0006303)3.64236884
28kinetochore organization (GO:0051383)3.63769943
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.62903054
30somatic hypermutation of immunoglobulin genes (GO:0016446)3.62903054
31establishment of chromosome localization (GO:0051303)3.61150202
32DNA replication-independent nucleosome organization (GO:0034724)3.60695822
33DNA replication-independent nucleosome assembly (GO:0006336)3.60695822
34IMP biosynthetic process (GO:0006188)3.59641392
35pore complex assembly (GO:0046931)3.55102212
36sister chromatid segregation (GO:0000819)3.54989012
37protein localization to chromosome, centromeric region (GO:0071459)3.52097821
38telomere maintenance via telomere lengthening (GO:0010833)3.50871207
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.48095020
40regulation of centriole replication (GO:0046599)3.48083201
41nucleobase biosynthetic process (GO:0046112)3.47845433
42negative regulation of chromosome segregation (GO:0051985)3.47360116
43regulation of spindle organization (GO:0090224)3.46385761
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.45247556
45negative regulation of sister chromatid segregation (GO:0033046)3.45247556
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.45247556
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.45247556
48maturation of 5.8S rRNA (GO:0000460)3.43580393
49spindle assembly checkpoint (GO:0071173)3.42889620
50DNA replication checkpoint (GO:0000076)3.41252380
51mismatch repair (GO:0006298)3.38855250
52mitotic spindle assembly checkpoint (GO:0007094)3.38679836
53synapsis (GO:0007129)3.38033157
54spindle checkpoint (GO:0031577)3.36356759
55folic acid-containing compound biosynthetic process (GO:0009396)3.36329302
56formation of translation preinitiation complex (GO:0001731)3.36257952
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.35958673
58protein K6-linked ubiquitination (GO:0085020)3.35302671
59regulation of centrosome cycle (GO:0046605)3.34775463
60histone exchange (GO:0043486)3.34265457
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34176645
62DNA geometric change (GO:0032392)3.32802239
63DNA strand renaturation (GO:0000733)3.32682336
64DNA duplex unwinding (GO:0032508)3.31477201
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30072353
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30067872
67regulation of mitotic spindle checkpoint (GO:1903504)3.29414000
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.29414000
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27385363
70regulation of helicase activity (GO:0051095)3.26581666
71mitotic spindle checkpoint (GO:0071174)3.25996986
72V(D)J recombination (GO:0033151)3.25471445
73regulation of chromosome segregation (GO:0051983)3.25131824
74purine nucleobase biosynthetic process (GO:0009113)3.24569420
75proteasome assembly (GO:0043248)3.23396449
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23239471
77somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.23053827
78somatic cell DNA recombination (GO:0016444)3.23053827
79mitotic sister chromatid cohesion (GO:0007064)3.22054464
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21497812
81regulation of mitotic sister chromatid separation (GO:0010965)3.20577772
82regulation of mitotic sister chromatid segregation (GO:0033047)3.20577772
83regulation of sister chromatid segregation (GO:0033045)3.20577772
84mitochondrial RNA metabolic process (GO:0000959)3.17135210
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16990015
86isotype switching (GO:0045190)3.16990015
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16990015
88kinetochore assembly (GO:0051382)3.15366420
89replication fork processing (GO:0031297)3.14511908
90establishment of viral latency (GO:0019043)3.14148896
91somatic diversification of immune receptors (GO:0002200)3.13578696
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12731520
93DNA double-strand break processing (GO:0000729)3.12473809
94pseudouridine synthesis (GO:0001522)3.10913107
95regulation of DNA endoreduplication (GO:0032875)3.10702791
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09505972
97rRNA modification (GO:0000154)3.09382014
98negative regulation of DNA-dependent DNA replication (GO:2000104)3.08568453
99DNA catabolic process, exonucleolytic (GO:0000738)3.07791757
100postreplication repair (GO:0006301)3.05156115
101regulation of nuclear cell cycle DNA replication (GO:0033262)3.03932218
102regulation of mitotic spindle organization (GO:0060236)3.03909701
103chromosome segregation (GO:0007059)3.03311089
104telomere maintenance (GO:0000723)3.01727649
105positive regulation of chromosome segregation (GO:0051984)3.01454474
106IMP metabolic process (GO:0046040)3.00814512
107cullin deneddylation (GO:0010388)3.00649860
108telomere organization (GO:0032200)2.99424027
109negative regulation of ligase activity (GO:0051352)2.98859095
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98859095
111regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98472705
112regulation of histone H3-K9 methylation (GO:0051570)2.97556593
113regulation of double-strand break repair via homologous recombination (GO:0010569)2.97128844
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96814239
115ribosome assembly (GO:0042255)2.96745730
116somatic recombination of immunoglobulin gene segments (GO:0016447)2.96005933
117ATP-dependent chromatin remodeling (GO:0043044)2.95254463
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95221965
119chromatin assembly or disassembly (GO:0006333)2.95126935
120DNA conformation change (GO:0071103)2.95035727
121dosage compensation (GO:0007549)2.92898006
122translesion synthesis (GO:0019985)2.92827536
123ribosome biogenesis (GO:0042254)2.91779318
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91731069
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91643903
126positive regulation of mitotic sister chromatid separation (GO:1901970)2.90696734
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90696734
128positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90696734
129spliceosomal snRNP assembly (GO:0000387)2.90201010
130tRNA methylation (GO:0030488)2.90035092
131regulation of gene silencing by RNA (GO:0060966)2.89523769
132regulation of posttranscriptional gene silencing (GO:0060147)2.89523769
133regulation of gene silencing by miRNA (GO:0060964)2.89523769
134amino acid activation (GO:0043038)2.89041970
135* nuclear envelope organization (GO:0006998)2.87200582
136DNA topological change (GO:0006265)2.86120993
137transcription-coupled nucleotide-excision repair (GO:0006283)2.85414490
138regulation of centrosome duplication (GO:0010824)2.84740402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.68808800
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.20972796
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.89377189
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39644872
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.84156189
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.79457981
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78200508
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78165385
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72534762
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69864137
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.62978345
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57666361
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47483645
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45017400
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.35834623
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32905799
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31063102
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.23202703
19* ETS1_20019798_ChIP-Seq_JURKAT_Human2.22502435
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19469966
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18082839
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13377313
23XRN2_22483619_ChIP-Seq_HELA_Human2.11776866
24* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01860971
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01744093
26AR_21909140_ChIP-Seq_LNCAP_Human2.00734034
27E2F7_22180533_ChIP-Seq_HELA_Human10.0283991
28VDR_23849224_ChIP-Seq_CD4+_Human1.97987914
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.95095984
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86439866
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83714343
32FOXP3_21729870_ChIP-Seq_TREG_Human1.82328159
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81547614
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80969669
35ELK1_19687146_ChIP-ChIP_HELA_Human1.79957397
36CIITA_25753668_ChIP-Seq_RAJI_Human1.79861004
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75682037
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.73061453
39DCP1A_22483619_ChIP-Seq_HELA_Human1.72611414
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67210843
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.65827998
42GABP_19822575_ChIP-Seq_HepG2_Human1.64904479
43TTF2_22483619_ChIP-Seq_HELA_Human1.64248115
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60415434
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59757469
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56290992
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51466460
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50911039
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50832836
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50388292
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50174673
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49739112
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48769264
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46732955
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45254999
56ZNF274_21170338_ChIP-Seq_K562_Hela1.44544295
57MYC_22102868_ChIP-Seq_BL_Human1.40482476
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.38605758
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38338580
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37497263
61* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36583826
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35137806
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35122757
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34307000
65IRF1_19129219_ChIP-ChIP_H3396_Human1.33649543
66KDM5A_27292631_Chip-Seq_BREAST_Human1.30991797
67EWS_26573619_Chip-Seq_HEK293_Human1.27356717
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.26475546
69TFEB_21752829_ChIP-Seq_HELA_Human1.25756076
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23468163
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21072636
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17671468
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14980488
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13895999
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11843739
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10262487
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09987863
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08887218
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07403299
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07292873
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06672413
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04502538
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04502538
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04502538
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.04393963
86FUS_26573619_Chip-Seq_HEK293_Human1.03315626
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01308622
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00594168
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99527638
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99519003
91* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98501785
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96834243
93* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95562312
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94080236
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93791546
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92773727
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91898621
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90299299
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89521167
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88257019
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87952253
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87130582
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86223240
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85467348
105IGF1R_20145208_ChIP-Seq_DFB_Human0.84980528
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84666339
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84052313
108* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83735799
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.83055574
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82762553
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.81379009
112MYC_18940864_ChIP-ChIP_HL60_Human0.81346820
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80782596
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79601274
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77527030
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.75682504
117VDR_22108803_ChIP-Seq_LS180_Human0.75394342
118* SOX17_20123909_ChIP-Seq_XEN_Mouse0.74690655
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.74549627
120TP53_22573176_ChIP-Seq_HFKS_Human0.67888543
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66403435
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63154940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.90667534
2MP0003693_abnormal_embryo_hatching4.56525742
3MP0003111_abnormal_nucleus_morphology4.32039675
4MP0008057_abnormal_DNA_replication4.10695102
5MP0008058_abnormal_DNA_repair3.85972746
6MP0003077_abnormal_cell_cycle3.83526214
7MP0004957_abnormal_blastocyst_morpholog3.68915397
8MP0008877_abnormal_DNA_methylation3.50679049
9MP0008007_abnormal_cellular_replicative3.38584726
10MP0003123_paternal_imprinting2.63396325
11MP0008932_abnormal_embryonic_tissue2.46288690
12MP0010307_abnormal_tumor_latency2.34377972
13MP0003121_genomic_imprinting2.29334506
14MP0003786_premature_aging2.19166965
15MP0006292_abnormal_olfactory_placode2.17195943
16MP0009697_abnormal_copulation2.15038036
17MP0000350_abnormal_cell_proliferation2.12427190
18MP0000372_irregular_coat_pigmentation2.09885877
19MP0001730_embryonic_growth_arrest2.09145134
20MP0010352_gastrointestinal_tract_polyps1.90745047
21MP0002163_abnormal_gland_morphology1.86962568
22MP0003890_abnormal_embryonic-extraembry1.77354940
23MP0006072_abnormal_retinal_apoptosis1.71860324
24MP0001697_abnormal_embryo_size1.69323843
25MP0001672_abnormal_embryogenesis/_devel1.69034880
26MP0005380_embryogenesis_phenotype1.69034880
27MP0002396_abnormal_hematopoietic_system1.66935945
28MP0002085_abnormal_embryonic_tissue1.60423311
29MP0002084_abnormal_developmental_patter1.56549969
30MP0001293_anophthalmia1.55950486
31MP0002210_abnormal_sex_determination1.52941064
32MP0003984_embryonic_growth_retardation1.52144979
33MP0003806_abnormal_nucleotide_metabolis1.50537155
34MP0002088_abnormal_embryonic_growth/wei1.48369243
35MP0006035_abnormal_mitochondrial_morpho1.48117445
36MP0004197_abnormal_fetal_growth/weight/1.47311112
37MP0006036_abnormal_mitochondrial_physio1.46292857
38MP0002080_prenatal_lethality1.46095052
39MP0004808_abnormal_hematopoietic_stem1.41598251
40MP0000313_abnormal_cell_death1.41203626
41MP0002653_abnormal_ependyma_morphology1.39875940
42MP0000490_abnormal_crypts_of1.34512275
43MP0002086_abnormal_extraembryonic_tissu1.31377463
44MP0003941_abnormal_skin_development1.30727944
45MP0010030_abnormal_orbit_morphology1.29485847
46MP0002019_abnormal_tumor_incidence1.29412497
47MP0001145_abnormal_male_reproductive1.25827344
48MP0001929_abnormal_gametogenesis1.25099571
49MP0002166_altered_tumor_susceptibility1.24327477
50MP0003787_abnormal_imprinting1.24311865
51MP0002132_abnormal_respiratory_system1.22316999
52MP0003718_maternal_effect1.20825976
53MP0005076_abnormal_cell_differentiation1.20743655
54MP0002006_tumorigenesis1.20262777
55MP0003646_muscle_fatigue1.18343588
56MP0003567_abnormal_fetal_cardiomyocyte1.18029425
57MP0001529_abnormal_vocalization1.15889677
58MP0005075_abnormal_melanosome_morpholog1.14180749
59MP0003122_maternal_imprinting1.13447213
60MP0004133_heterotaxia1.12632247
61MP0004147_increased_porphyrin_level1.12088772
62MP0002938_white_spotting1.11800585
63MP0000653_abnormal_sex_gland1.07692971
64MP0005645_abnormal_hypothalamus_physiol1.03476262
65MP0001873_stomach_inflammation1.00902585
66MP0005379_endocrine/exocrine_gland_phen1.00505808
67MP0000703_abnormal_thymus_morphology1.00275628
68MP0002254_reproductive_system_inflammat0.98369422
69MP0003119_abnormal_digestive_system0.97580019
70MP0001764_abnormal_homeostasis0.95494247
71MP0001119_abnormal_female_reproductive0.94410186
72MP0009333_abnormal_splenocyte_physiolog0.94323421
73MP0003763_abnormal_thymus_physiology0.94171615
74MP0000516_abnormal_urinary_system0.93462596
75MP0005367_renal/urinary_system_phenotyp0.93462596
76MP0008789_abnormal_olfactory_epithelium0.92264810
77MP0009703_decreased_birth_body0.92033521
78MP0003937_abnormal_limbs/digits/tail_de0.90526310
79MP0005397_hematopoietic_system_phenotyp0.90435110
80MP0001545_abnormal_hematopoietic_system0.90435110
81MP0003186_abnormal_redox_activity0.90359851
82MP0005384_cellular_phenotype0.89751462
83MP0002398_abnormal_bone_marrow0.89123333
84MP0005395_other_phenotype0.87804991
85MP0001286_abnormal_eye_development0.85849348
86MP0000358_abnormal_cell_content/0.84385019
87MP0000678_abnormal_parathyroid_gland0.83691867
88MP0002160_abnormal_reproductive_system0.82366476
89MP0003221_abnormal_cardiomyocyte_apopto0.82357630
90MP0002009_preneoplasia0.82269883
91MP0005220_abnormal_exocrine_pancreas0.80782306
92MP0005621_abnormal_cell_physiology0.80261715
93MP0003698_abnormal_male_reproductive0.79321981
94MP0002102_abnormal_ear_morphology0.78503249
95MP0002722_abnormal_immune_system0.78377490
96MP0001727_abnormal_embryo_implantation0.78289595
97MP0005253_abnormal_eye_physiology0.78257236
98MP0002697_abnormal_eye_size0.77402613
99MP0002095_abnormal_skin_pigmentation0.77124906
100MP0000858_altered_metastatic_potential0.76933075
101MP0009672_abnormal_birth_weight0.75832365
102MP0009278_abnormal_bone_marrow0.74881745
103MP0002092_abnormal_eye_morphology0.74687532
104MP0001348_abnormal_lacrimal_gland0.74603848
105MP0005266_abnormal_metabolism0.73359748
106MP0002127_abnormal_cardiovascular_syste0.70665969
107MP0000689_abnormal_spleen_morphology0.70482938
108MP0003315_abnormal_perineum_morphology0.70135143
109MP0005084_abnormal_gallbladder_morpholo0.69521451
110MP0004264_abnormal_extraembryonic_tissu0.69351152
111MP0002837_dystrophic_cardiac_calcinosis0.69036543
112MP0000428_abnormal_craniofacial_morphol0.68469701
113MP0001915_intracranial_hemorrhage0.68198532
114MP0002111_abnormal_tail_morphology0.67774169
115MP0002876_abnormal_thyroid_physiology0.67618280
116MP0003699_abnormal_female_reproductive0.67013434
117MP0001919_abnormal_reproductive_system0.65133242
118MP0005389_reproductive_system_phenotype0.64959300
119MP0009053_abnormal_anal_canal0.64678310
120MP0002429_abnormal_blood_cell0.64178908
121MP0003943_abnormal_hepatobiliary_system0.63861371
122MP0003935_abnormal_craniofacial_develop0.62667893
123MP0001661_extended_life_span0.62513883
124MP0000566_synostosis0.62207933
125MP0003942_abnormal_urinary_system0.62044148
126MP0008995_early_reproductive_senescence0.61478981
127MP0001835_abnormal_antigen_presentation0.60943956
128MP0000537_abnormal_urethra_morphology0.60835818
129MP0000569_abnormal_digit_pigmentation0.60359665
130MP0003861_abnormal_nervous_system0.60301595
131MP0002161_abnormal_fertility/fecundity0.59917834
132MP0003115_abnormal_respiratory_system0.59368255
133MP0004215_abnormal_myocardial_fiber0.59110058
134MP0006054_spinal_hemorrhage0.58470264
135MP0000432_abnormal_head_morphology0.56426165
136MP0002751_abnormal_autonomic_nervous0.56284257
137MP0005174_abnormal_tail_pigmentation0.55003274
138MP0000647_abnormal_sebaceous_gland0.54621715

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.94881934
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.94236751
3Birth length less than 3rd percentile (HP:0003561)4.06401165
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.78150221
5Abnormality of chromosome stability (HP:0003220)3.75316942
6Medulloblastoma (HP:0002885)3.68868475
7Meckel diverticulum (HP:0002245)3.66381996
8Abnormality of the ileum (HP:0001549)3.57859448
9Ependymoma (HP:0002888)3.46922959
10Abnormality of the preputium (HP:0100587)3.41886667
11Selective tooth agenesis (HP:0001592)3.40336952
12Colon cancer (HP:0003003)3.38084431
13B lymphocytopenia (HP:0010976)3.33565948
14Agnosia (HP:0010524)3.30840266
15Patellar aplasia (HP:0006443)3.28698510
16Microvesicular hepatic steatosis (HP:0001414)3.18123820
17Abnormality of B cell number (HP:0010975)3.09650910
18Combined immunodeficiency (HP:0005387)3.05345612
19Ectopic kidney (HP:0000086)3.02996126
20Aplasia/Hypoplasia of the patella (HP:0006498)3.01819047
21Myelodysplasia (HP:0002863)3.00229254
22Severe combined immunodeficiency (HP:0004430)2.99516640
23Duodenal stenosis (HP:0100867)2.97922647
24Small intestinal stenosis (HP:0012848)2.97922647
25Panhypogammaglobulinemia (HP:0003139)2.90077872
26Abnormal number of incisors (HP:0011064)2.85121117
27Impulsivity (HP:0100710)2.82197104
28Abnormality of the labia minora (HP:0012880)2.81708336
29Type I transferrin isoform profile (HP:0003642)2.80808179
30Hepatocellular necrosis (HP:0001404)2.79039422
31Supernumerary spleens (HP:0009799)2.78349647
3211 pairs of ribs (HP:0000878)2.75854257
33Degeneration of anterior horn cells (HP:0002398)2.74171785
34Abnormality of the anterior horn cell (HP:0006802)2.74171785
35Abnormality of DNA repair (HP:0003254)2.66968270
36Abnormality of the carotid arteries (HP:0005344)2.66313734
37Abnormal protein glycosylation (HP:0012346)2.63749497
38Abnormal glycosylation (HP:0012345)2.63749497
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63749497
40Abnormal protein N-linked glycosylation (HP:0012347)2.63749497
41Increased CSF lactate (HP:0002490)2.62036087
42Breast hypoplasia (HP:0003187)2.61276520
43Sloping forehead (HP:0000340)2.59632225
44Absent radius (HP:0003974)2.58614720
45Abnormality of the duodenum (HP:0002246)2.57768264
46Increased serum lactate (HP:0002151)2.56929526
47Nephroblastoma (Wilms tumor) (HP:0002667)2.53762586
48Hepatic necrosis (HP:0002605)2.53684287
49Abnormal lung lobation (HP:0002101)2.52894938
50Mitochondrial inheritance (HP:0001427)2.51263156
51Hypoplasia of the thymus (HP:0000778)2.49213435
52Reticulocytopenia (HP:0001896)2.49071514
53Bone marrow hypocellularity (HP:0005528)2.48460378
54Increased hepatocellular lipid droplets (HP:0006565)2.45955835
55Oral leukoplakia (HP:0002745)2.45377960
56Rhabdomyosarcoma (HP:0002859)2.44470354
57Aplasia involving forearm bones (HP:0009822)2.44387311
58Absent forearm bone (HP:0003953)2.44387311
59Lipid accumulation in hepatocytes (HP:0006561)2.43854757
60Optic nerve coloboma (HP:0000588)2.42601666
61Embryonal renal neoplasm (HP:0011794)2.41814027
62Amaurosis fugax (HP:0100576)2.39718966
63Clubbing of toes (HP:0100760)2.38593931
64Neoplasm of the oral cavity (HP:0100649)2.36843457
65Absent thumb (HP:0009777)2.35977441
66Acute necrotizing encephalopathy (HP:0006965)2.35096959
67Prominent metopic ridge (HP:0005487)2.35044295
68Increased nuchal translucency (HP:0010880)2.34006731
69Acute encephalopathy (HP:0006846)2.33783543
70Missing ribs (HP:0000921)2.32575495
71Astrocytoma (HP:0009592)2.30076072
72Abnormality of the astrocytes (HP:0100707)2.30076072
73Abnormal mitochondria in muscle tissue (HP:0008316)2.29735203
74Neoplasm of the pancreas (HP:0002894)2.28665974
75Pancytopenia (HP:0001876)2.28132697
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.28080612
77Abnormality of the pons (HP:0007361)2.26750622
78Duplicated collecting system (HP:0000081)2.25379334
79Multiple enchondromatosis (HP:0005701)2.25313936
80Abnormality of the metopic suture (HP:0005556)2.25060548
81Cafe-au-lait spot (HP:0000957)2.24425745
82Volvulus (HP:0002580)2.23599842
83Cerebral edema (HP:0002181)2.21986297
84Hypoproteinemia (HP:0003075)2.20322457
85Glioma (HP:0009733)2.20232713
86IgG deficiency (HP:0004315)2.19599531
87Aplastic anemia (HP:0001915)2.17760143
88Lactic acidosis (HP:0003128)2.13004370
89Tracheoesophageal fistula (HP:0002575)2.12875995
90Facial cleft (HP:0002006)2.11876543
91Intestinal atresia (HP:0011100)2.11653775
92Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09070684
93Short 4th metacarpal (HP:0010044)2.09070684
94Premature graying of hair (HP:0002216)2.08712505
95Abnormality of the renal collecting system (HP:0004742)2.07986791
96Thyroiditis (HP:0100646)2.07514119
97Reduced antithrombin III activity (HP:0001976)2.05339582
98Short thumb (HP:0009778)2.04266135
99Increased serum pyruvate (HP:0003542)2.00871085
100Triphalangeal thumb (HP:0001199)2.00523099
101Neoplasm of the adrenal cortex (HP:0100641)1.98969971
102Prominent nose (HP:0000448)1.98797843
103Carpal bone hypoplasia (HP:0001498)1.96252838
104Proximal placement of thumb (HP:0009623)1.95375167
105Increased intramyocellular lipid droplets (HP:0012240)1.94691677
106Abnormality of methionine metabolism (HP:0010901)1.92904874
107Deviation of the thumb (HP:0009603)1.91708965
108Squamous cell carcinoma (HP:0002860)1.91490568
109Progressive muscle weakness (HP:0003323)1.89554439
110Abnormality of abdominal situs (HP:0011620)1.89104630
111Abdominal situs inversus (HP:0003363)1.89104630
112Horseshoe kidney (HP:0000085)1.87980003
113Agammaglobulinemia (HP:0004432)1.87897029
114Methylmalonic acidemia (HP:0002912)1.85970545
115Progressive macrocephaly (HP:0004481)1.85910618
116Abnormality of glycolysis (HP:0004366)1.85354451
117Rib fusion (HP:0000902)1.84669028
118Breast carcinoma (HP:0003002)1.84452333
119Premature ovarian failure (HP:0008209)1.83184990
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83128297
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83128297
122Rough bone trabeculation (HP:0100670)1.82897873
123IgM deficiency (HP:0002850)1.82487841
124Acute myeloid leukemia (HP:0004808)1.81720602
125Respiratory difficulties (HP:0002880)1.80768108
126High pitched voice (HP:0001620)1.79104833
127Poikiloderma (HP:0001029)1.78141649
1283-Methylglutaconic aciduria (HP:0003535)1.77093470
129Abnormality of alanine metabolism (HP:0010916)1.76305547
130Hyperalaninemia (HP:0003348)1.76305547
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76305547
132Neoplasm of striated muscle (HP:0009728)1.75982831
133Pelvic girdle muscle weakness (HP:0003749)1.75903930
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75124252
135Freckling (HP:0001480)1.74975541
136Cellular immunodeficiency (HP:0005374)1.74751529
137Abnormal spermatogenesis (HP:0008669)1.74636898
138Ovarian neoplasm (HP:0100615)1.74076089
139Exercise intolerance (HP:0003546)1.73901907
140Neoplasm of the adrenal gland (HP:0100631)1.73339388
141Hypoplasia of the pons (HP:0012110)1.73335853
142Progressive inability to walk (HP:0002505)1.72392413
143Basal cell carcinoma (HP:0002671)1.71780342
144Skull defect (HP:0001362)1.71558592
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71100056
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69607687
147Biliary tract neoplasm (HP:0100574)1.69515564
148Lymphoma (HP:0002665)1.68936647
149Neoplasm of the colon (HP:0100273)1.68899606
150Papillary thyroid carcinoma (HP:0002895)1.67787156
151Facial hemangioma (HP:0000329)1.67389101
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.67111148
153Acute lymphatic leukemia (HP:0006721)1.65416950
154Shoulder girdle muscle weakness (HP:0003547)1.64597423
155Abnormal trabecular bone morphology (HP:0100671)1.64309348
156Deep philtrum (HP:0002002)1.64114950
157Severe visual impairment (HP:0001141)1.63707063
158Aplasia/hypoplasia of the humerus (HP:0006507)1.62810370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.29322615
2BUB13.80085360
3WEE13.34261979
4VRK23.10508328
5NEK23.04693292
6CDK122.92356133
7ACVR1B2.84758257
8TTK2.70677899
9TSSK62.65304290
10SRPK12.61350159
11PLK42.61220225
12NEK12.47621949
13MST42.26451288
14EIF2AK12.21921030
15ATR2.20234231
16PLK12.14255505
17PASK2.05406533
18STK162.02298724
19TAF12.00509693
20NUAK11.97161757
21BRSK21.95795892
22BRD41.93168535
23PLK31.93102765
24TRIM281.87869869
25CHEK21.82586476
26MKNK11.78960400
27CDK71.78605614
28AURKB1.71640286
29VRK11.69335892
30ZAK1.67262456
31CHEK11.50428570
32DYRK31.49504083
33EPHA21.48166754
34CCNB11.46416826
35EIF2AK31.40448329
36RPS6KA41.38845684
37MAP4K21.38620391
38RPS6KB21.38119028
39MKNK21.36399911
40STK31.29035907
41FLT31.28863932
42STK41.28232831
43BCKDK1.24285985
44MAP3K81.20481227
45WNK31.18389189
46ATM1.18018636
47STK38L1.16970730
48BRSK11.13685053
49TGFBR11.12105712
50TESK11.11918897
51STK101.11574764
52CDK41.09197726
53NME21.08368643
54AURKA1.06650313
55EEF2K1.03337320
56CDK20.99906318
57TESK20.96121586
58STK390.94356660
59MAP3K120.86325433
60YES10.85765942
61CDK10.85184644
62EIF2AK20.81427968
63TAOK20.81273339
64BRAF0.79909203
65PIM10.78295999
66ALK0.72457553
67KDR0.71299525
68ERBB30.69348886
69CSNK1G10.68909272
70SCYL20.68535539
71CDK60.68450689
72CSNK1G30.66543709
73WNK40.66105099
74BCR0.65952771
75ERBB40.65332285
76CDK190.61304744
77CHUK0.60611399
78GRK10.60515707
79MAP3K40.59906888
80LIMK10.59297428
81PDK30.57508411
82PDK40.57508411
83MELK0.57273303
84CSNK2A20.56855208
85SMG10.54591194
86CDK90.54568632
87DYRK1B0.54075726
88TLK10.53957478
89MAPKAPK50.53813368
90DAPK10.53742794
91STK240.53740379
92CSNK2A10.52399002
93CSNK1A1L0.52394779
94PRKDC0.52083667
95JAK30.51778704
96TAOK30.49733762
97DYRK20.49642850
98OXSR10.49464831
99LATS10.49100034
100MAP3K130.48556891
101FRK0.47226286
102PAK10.46685132
103PNCK0.46483134
104PAK40.46431302
105MAP3K140.46318794
106MAP2K70.45978676
107MTOR0.44967479
108NME10.44393611
109MAPK140.44075394
110MET0.43742308
111AKT30.42576699
112TEC0.41942908
113PDK20.41573596
114RPS6KA50.39930509
115SIK30.38073163
116RPS6KB10.37737801
117MAP3K50.36348021
118TYK20.36291127
119CSNK1G20.34805585
120CDK80.34758814
121INSRR0.33686089
122CLK10.33453642
123PBK0.33428580
124CDK30.32655525
125MAP3K100.32348182
126GSK3B0.31737109
127CSNK1E0.31716736
128AKT10.30794285
129IKBKB0.30327733
130BMPR1B0.26971970
131PRKCI0.26965469
132TXK0.26877098
133CSNK1D0.26784902
134MAPK10.26358980
135MAP4K10.25745097
136AKT20.22440834
137NEK90.22254035
138FGFR10.21901649

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62615540
2Mismatch repair_Homo sapiens_hsa034304.39592905
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47709637
4Homologous recombination_Homo sapiens_hsa034403.29962500
5Base excision repair_Homo sapiens_hsa034103.28867675
6Spliceosome_Homo sapiens_hsa030403.18231162
7* RNA transport_Homo sapiens_hsa030133.06741608
8Cell cycle_Homo sapiens_hsa041103.03939289
9Nucleotide excision repair_Homo sapiens_hsa034203.02678235
10Fanconi anemia pathway_Homo sapiens_hsa034602.90317196
11One carbon pool by folate_Homo sapiens_hsa006702.72898025
12RNA polymerase_Homo sapiens_hsa030202.54258327
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53306772
14Non-homologous end-joining_Homo sapiens_hsa034502.47601124
15Proteasome_Homo sapiens_hsa030502.46684669
16Basal transcription factors_Homo sapiens_hsa030222.19032374
17RNA degradation_Homo sapiens_hsa030182.15675768
18Pyrimidine metabolism_Homo sapiens_hsa002402.02547978
19mRNA surveillance pathway_Homo sapiens_hsa030151.84031537
20p53 signaling pathway_Homo sapiens_hsa041151.79817854
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54049786
22Ribosome_Homo sapiens_hsa030101.47548845
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46958392
24Propanoate metabolism_Homo sapiens_hsa006401.43466196
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38829383
26Epstein-Barr virus infection_Homo sapiens_hsa051691.36357743
27Oxidative phosphorylation_Homo sapiens_hsa001901.35605181
28Systemic lupus erythematosus_Homo sapiens_hsa053221.34021393
29Parkinsons disease_Homo sapiens_hsa050121.30922907
30Herpes simplex infection_Homo sapiens_hsa051681.30117525
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28833108
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24814962
33Viral carcinogenesis_Homo sapiens_hsa052031.21513425
34Pyruvate metabolism_Homo sapiens_hsa006201.19330341
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15569996
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15166430
37Purine metabolism_Homo sapiens_hsa002301.12566304
38Antigen processing and presentation_Homo sapiens_hsa046121.12091715
39Oocyte meiosis_Homo sapiens_hsa041141.05574701
40Fatty acid elongation_Homo sapiens_hsa000620.99495156
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99324360
42HTLV-I infection_Homo sapiens_hsa051660.98125144
43Huntingtons disease_Homo sapiens_hsa050160.93704542
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92157997
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90941577
46Carbon metabolism_Homo sapiens_hsa012000.88513040
47Sulfur relay system_Homo sapiens_hsa041220.87430989
48MicroRNAs in cancer_Homo sapiens_hsa052060.85286558
49Legionellosis_Homo sapiens_hsa051340.84468605
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82081201
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81122679
52Caffeine metabolism_Homo sapiens_hsa002320.81023112
53Butanoate metabolism_Homo sapiens_hsa006500.75785788
54Measles_Homo sapiens_hsa051620.74999574
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71397641
56Protein export_Homo sapiens_hsa030600.70487397
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.68019496
58Allograft rejection_Homo sapiens_hsa053300.67971559
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66997250
60Small cell lung cancer_Homo sapiens_hsa052220.65982519
61Primary immunodeficiency_Homo sapiens_hsa053400.65884458
62Selenocompound metabolism_Homo sapiens_hsa004500.65729123
63Fatty acid metabolism_Homo sapiens_hsa012120.65249046
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65154570
65Type I diabetes mellitus_Homo sapiens_hsa049400.64340473
66Notch signaling pathway_Homo sapiens_hsa043300.63255486
67Apoptosis_Homo sapiens_hsa042100.62928242
68Colorectal cancer_Homo sapiens_hsa052100.62087727
69Viral myocarditis_Homo sapiens_hsa054160.60892509
70Influenza A_Homo sapiens_hsa051640.59862381
71Peroxisome_Homo sapiens_hsa041460.59655214
72Regulation of autophagy_Homo sapiens_hsa041400.58746137
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57750467
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57144841
75Alcoholism_Homo sapiens_hsa050340.57057790
76Vitamin B6 metabolism_Homo sapiens_hsa007500.54461281
77Glutathione metabolism_Homo sapiens_hsa004800.54211100
78Metabolic pathways_Homo sapiens_hsa011000.53341823
79TGF-beta signaling pathway_Homo sapiens_hsa043500.51432227
80Steroid biosynthesis_Homo sapiens_hsa001000.49977813
81Hepatitis B_Homo sapiens_hsa051610.49840150
82Alzheimers disease_Homo sapiens_hsa050100.49817458
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.49500912
84Hippo signaling pathway_Homo sapiens_hsa043900.48911488
85Lysine degradation_Homo sapiens_hsa003100.48852867
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48401201
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48396772
88Biosynthesis of amino acids_Homo sapiens_hsa012300.46243780
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.46122190
90Chronic myeloid leukemia_Homo sapiens_hsa052200.41334343
91Thyroid cancer_Homo sapiens_hsa052160.41324784
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40793221
93Shigellosis_Homo sapiens_hsa051310.40791100
94Basal cell carcinoma_Homo sapiens_hsa052170.40771590
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.39610344
96Tryptophan metabolism_Homo sapiens_hsa003800.37927249
97Fatty acid degradation_Homo sapiens_hsa000710.36991925
98N-Glycan biosynthesis_Homo sapiens_hsa005100.36017710
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35831058
100Adherens junction_Homo sapiens_hsa045200.34997551
101Phototransduction_Homo sapiens_hsa047440.34354039
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33211066
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32033609
104Pathways in cancer_Homo sapiens_hsa052000.31902897
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30676593
106Pentose phosphate pathway_Homo sapiens_hsa000300.29294147
107Graft-versus-host disease_Homo sapiens_hsa053320.28473060
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.27938181
109Autoimmune thyroid disease_Homo sapiens_hsa053200.27386428
110HIF-1 signaling pathway_Homo sapiens_hsa040660.26736796
111Pancreatic cancer_Homo sapiens_hsa052120.25065084
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.24821313
113Hedgehog signaling pathway_Homo sapiens_hsa043400.23709979
114mTOR signaling pathway_Homo sapiens_hsa041500.23604858
115Prostate cancer_Homo sapiens_hsa052150.23010251
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.22759003
117Sulfur metabolism_Homo sapiens_hsa009200.21924631
118Endometrial cancer_Homo sapiens_hsa052130.21058476
119Toxoplasmosis_Homo sapiens_hsa051450.20971684
120Hematopoietic cell lineage_Homo sapiens_hsa046400.20872889
121Fructose and mannose metabolism_Homo sapiens_hsa000510.20374356
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20146108
123Folate biosynthesis_Homo sapiens_hsa007900.19620415
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19446446
125Bladder cancer_Homo sapiens_hsa052190.18842295
126FoxO signaling pathway_Homo sapiens_hsa040680.18274841
127T cell receptor signaling pathway_Homo sapiens_hsa046600.17234055
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17122399
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16200142
130Wnt signaling pathway_Homo sapiens_hsa043100.16068250
131Acute myeloid leukemia_Homo sapiens_hsa052210.15654877
132Arginine and proline metabolism_Homo sapiens_hsa003300.15563399
133Nitrogen metabolism_Homo sapiens_hsa009100.13124741
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12765826
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.11510919
136Melanoma_Homo sapiens_hsa052180.11119572
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11032865
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10611767
139Asthma_Homo sapiens_hsa053100.09822336
140Non-small cell lung cancer_Homo sapiens_hsa052230.09252260
141Circadian rhythm_Homo sapiens_hsa047100.09058933
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08650317

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