NUP98

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* nuclear pore complex assembly (GO:0051292)4.61215896
2* nuclear pore organization (GO:0006999)4.55930338
3chromosome condensation (GO:0030261)4.22844776
4DNA unwinding involved in DNA replication (GO:0006268)4.09954315
5mitotic metaphase plate congression (GO:0007080)3.91157685
6regulation of nucleobase-containing compound transport (GO:0032239)3.80684127
7meiotic chromosome segregation (GO:0045132)3.78759725
8negative regulation of DNA repair (GO:0045738)3.68401060
9kinetochore organization (GO:0051383)3.64584397
10regulation of histone H3-K27 methylation (GO:0061085)3.62437595
11metaphase plate congression (GO:0051310)3.61869612
12* pore complex assembly (GO:0046931)3.59092298
13mitotic sister chromatid cohesion (GO:0007064)3.56633093
14microtubule depolymerization (GO:0007019)3.54438796
15protein K6-linked ubiquitination (GO:0085020)3.45317242
16establishment of chromosome localization (GO:0051303)3.42609220
17protein localization to kinetochore (GO:0034501)3.38608589
18* mitotic nuclear envelope disassembly (GO:0007077)3.35677773
19protein localization to chromosome, centromeric region (GO:0071459)3.26799884
20protein export from nucleus (GO:0006611)3.22850783
21DNA conformation change (GO:0071103)3.22095229
22negative regulation of histone methylation (GO:0031061)3.21988058
23kinetochore assembly (GO:0051382)3.20926253
24sister chromatid cohesion (GO:0007062)3.19431465
25histone H3-K36 demethylation (GO:0070544)3.18675175
26DNA duplex unwinding (GO:0032508)3.17562896
27embryonic process involved in female pregnancy (GO:0060136)3.14980123
28chromatin remodeling at centromere (GO:0031055)3.12228765
29regulation of spindle organization (GO:0090224)3.12110431
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09565088
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09565088
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.09565088
33CENP-A containing nucleosome assembly (GO:0034080)3.07296047
34* nuclear envelope disassembly (GO:0051081)3.05944005
35* membrane disassembly (GO:0030397)3.05944005
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05109425
37IMP biosynthetic process (GO:0006188)3.01830370
38DNA geometric change (GO:0032392)2.99722776
39attachment of spindle microtubules to kinetochore (GO:0008608)2.96705866
40regulation of centriole replication (GO:0046599)2.96238031
41DNA replication checkpoint (GO:0000076)2.95957306
42regulation of histone H3-K9 methylation (GO:0051570)2.95923198
43piRNA metabolic process (GO:0034587)2.95397662
44negative regulation of DNA-dependent DNA replication (GO:2000104)2.94596082
45spliceosomal tri-snRNP complex assembly (GO:0000244)2.93593643
46regulation of mitotic spindle organization (GO:0060236)2.92845639
47histone exchange (GO:0043486)2.90781749
48COPI coating of Golgi vesicle (GO:0048205)2.89217121
49Golgi transport vesicle coating (GO:0048200)2.89217121
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87853363
51regulation of mitotic spindle checkpoint (GO:1903504)2.87853363
52mitotic sister chromatid segregation (GO:0000070)2.86731633
53regulation of sister chromatid cohesion (GO:0007063)2.86375312
54positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.86285441
55RNA stabilization (GO:0043489)2.82643005
56mRNA stabilization (GO:0048255)2.82643005
57DNA replication initiation (GO:0006270)2.80204642
58regulation of translational fidelity (GO:0006450)2.79589569
59DNA replication-independent nucleosome organization (GO:0034724)2.76683891
60DNA replication-independent nucleosome assembly (GO:0006336)2.76683891
61positive regulation of chromosome segregation (GO:0051984)2.76642836
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74889195
63mitotic chromosome condensation (GO:0007076)2.74541944
64DNA replication-dependent nucleosome organization (GO:0034723)2.73989136
65DNA replication-dependent nucleosome assembly (GO:0006335)2.73989136
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73448325
67inner cell mass cell proliferation (GO:0001833)2.72956250
68* nuclear envelope organization (GO:0006998)2.71610565
69NLS-bearing protein import into nucleus (GO:0006607)2.71256128
70sister chromatid segregation (GO:0000819)2.69813764
71regulation of nuclear cell cycle DNA replication (GO:0033262)2.68092064
72negative regulation of erythrocyte differentiation (GO:0045647)2.64498465
73monoubiquitinated protein deubiquitination (GO:0035520)2.63415367
74peptidyl-lysine dimethylation (GO:0018027)2.61732821
75pre-miRNA processing (GO:0031054)2.61430109
76telomere maintenance via recombination (GO:0000722)2.61248527
77RNA-dependent DNA replication (GO:0006278)2.61208651
78replication fork processing (GO:0031297)2.61158709
79regulation of spindle checkpoint (GO:0090231)2.61098041
80chromosome segregation (GO:0007059)2.59778157
81DNA synthesis involved in DNA repair (GO:0000731)2.58810442
82histone lysine demethylation (GO:0070076)2.58586403
83iron ion import (GO:0097286)2.57616046
84positive regulation of protein import into nucleus, translocation (GO:0033160)2.56582849
85* nucleus organization (GO:0006997)2.56540553
86synaptonemal complex assembly (GO:0007130)2.55191163
87maturation of 5.8S rRNA (GO:0000460)2.54687703
88regulation of double-strand break repair via homologous recombination (GO:0010569)2.54392214
89mitotic recombination (GO:0006312)2.54212659
90DNA packaging (GO:0006323)2.53155200
91mismatch repair (GO:0006298)2.52830337
92male meiosis (GO:0007140)2.52323649
93spindle checkpoint (GO:0031577)2.52150102
94histone demethylation (GO:0016577)2.51684926
95histone phosphorylation (GO:0016572)2.51139718
96telomere maintenance via semi-conservative replication (GO:0032201)2.50963139
97cellular protein complex localization (GO:0034629)2.50842119
98DNA double-strand break processing (GO:0000729)2.49978111
99histone H3-K9 demethylation (GO:0033169)2.48861357
100DNA topological change (GO:0006265)2.48579222
101chromosome organization involved in meiosis (GO:0070192)2.48386665
102definitive hemopoiesis (GO:0060216)2.48300178
103regulation of centrosome cycle (GO:0046605)2.47728316
104regulation of mitotic metaphase/anaphase transition (GO:0030071)2.46718794
105COPII vesicle coating (GO:0048208)2.46515061
106sperm-egg recognition (GO:0035036)2.46506303
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45846057
108ribosome assembly (GO:0042255)2.45305804
109DNA strand elongation involved in DNA replication (GO:0006271)2.44780348
110binding of sperm to zona pellucida (GO:0007339)2.44238343
111protein localization to endosome (GO:0036010)2.43733810
112histone H3-K9 methylation (GO:0051567)2.43165921
113regulation of RNA export from nucleus (GO:0046831)2.42947753
114pinocytosis (GO:0006907)2.42894834
115dosage compensation (GO:0007549)2.42873425
116protein localization to chromosome (GO:0034502)2.42870471
117multicellular organism reproduction (GO:0032504)2.42380948
118reciprocal DNA recombination (GO:0035825)2.41818703
119reciprocal meiotic recombination (GO:0007131)2.41818703
120regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.41279535
121ATP-dependent chromatin remodeling (GO:0043044)2.41179789
122regulation of helicase activity (GO:0051095)2.41122289
123regulation of chromosome segregation (GO:0051983)2.41033377
124IMP metabolic process (GO:0046040)2.40907057
125centriole replication (GO:0007099)2.40652612
126protein complex localization (GO:0031503)2.40215315
127cilium or flagellum-dependent cell motility (GO:0001539)2.39716884
128regulation of double-strand break repair (GO:2000779)2.39208766
129heterochromatin organization (GO:0070828)2.38401537
130negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.38109149
131regulation of DNA endoreduplication (GO:0032875)2.37984761
132regulation of translational termination (GO:0006449)2.37689027
133DNA strand elongation (GO:0022616)2.37558183
134paraxial mesoderm development (GO:0048339)2.37070659
135fusion of sperm to egg plasma membrane (GO:0007342)2.37024448
136regulation of NFAT protein import into nucleus (GO:0051532)2.36555277
1373-UTR-mediated mRNA stabilization (GO:0070935)2.35460633
138telomere maintenance (GO:0000723)2.35210967
139centriole assembly (GO:0098534)2.34285666
140response to epidermal growth factor (GO:0070849)2.34148962
141meiotic cell cycle (GO:0051321)2.33940357
142synaptonemal complex organization (GO:0070193)2.33721563
143regulation of posttranscriptional gene silencing (GO:0060147)2.33252759
144regulation of gene silencing by miRNA (GO:0060964)2.33252759
145regulation of gene silencing by RNA (GO:0060966)2.33252759
146nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.30675917
147cell-substrate adherens junction assembly (GO:0007045)2.30132069
148focal adhesion assembly (GO:0048041)2.30132069
149cytoplasmic mRNA processing body assembly (GO:0033962)2.29511670
150positive regulation of gamma-delta T cell activation (GO:0046645)2.28971017
151activation of Rac GTPase activity (GO:0032863)2.28131428
152cell-substrate junction assembly (GO:0007044)2.27993907
153hypotonic response (GO:0006971)2.26987904
154glucocorticoid receptor signaling pathway (GO:0042921)2.26897304
155regulation of DNA damage checkpoint (GO:2000001)2.26554420
156negative regulation of histone modification (GO:0031057)2.22164026
157regulation of histone methylation (GO:0031060)2.21492267
158hepatocyte apoptotic process (GO:0097284)2.21132584
159corticosteroid receptor signaling pathway (GO:0031958)2.21107360
160cellular response to epidermal growth factor stimulus (GO:0071364)2.21017536
161cellular hyperosmotic response (GO:0071474)2.20114925
162necroptotic process (GO:0070266)2.19882231
163protein demethylation (GO:0006482)2.18557012
164protein dealkylation (GO:0008214)2.18557012
165adherens junction assembly (GO:0034333)2.16985647
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.16831096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.98901350
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.50836700
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11260509
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.38204197
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.37348207
6MYC_22102868_ChIP-Seq_BL_Human3.09610271
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.96600250
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.80052092
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.72142668
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71542330
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36634954
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.27927240
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.10958647
14MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04474635
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93804254
16ELK1_19687146_ChIP-ChIP_HELA_Human1.90090940
17TCF7_22412390_ChIP-Seq_EML_Mouse1.89632566
18AR_21909140_ChIP-Seq_LNCAP_Human1.87546658
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.84937227
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79986097
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.77929166
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77672715
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76565848
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76036972
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74727021
26VDR_21846776_ChIP-Seq_THP-1_Human1.74094758
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73826142
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72726263
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70354992
30* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69405050
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65568105
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65165664
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.64262322
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.63365105
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60471539
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60400410
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59671328
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55138810
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55138810
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55138810
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54374354
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.53956773
43TFEB_21752829_ChIP-Seq_HELA_Human1.53493538
44GATA1_22025678_ChIP-Seq_K562_Human1.50113928
45MAF_26560356_Chip-Seq_TH1_Human1.46762326
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46297293
47VDR_23849224_ChIP-Seq_CD4+_Human1.46237330
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45827476
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45615693
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45018718
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.44507311
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43900715
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43070971
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42636154
55* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41974851
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41550123
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.40114580
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40020787
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.38325081
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37348747
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37328990
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36804610
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36221096
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33089249
65CLOCK_20551151_ChIP-Seq_293T_Human1.32880633
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32779421
67SCL_19346495_ChIP-Seq_HPC-7_Human1.29434184
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29336544
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28507337
70NCOR1_26117541_ChIP-Seq_K562_Human1.25677765
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23169468
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23028691
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22982466
74VDR_24763502_ChIP-Seq_THP-1_Human1.22695665
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22619257
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21545835
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19329351
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19233916
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19065357
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17430597
81CHD1_26751641_Chip-Seq_LNCaP_Human1.17351424
82ATF3_27146783_Chip-Seq_COLON_Human1.17097081
83* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16627697
84* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16611403
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15148282
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.14964888
87FOXP3_21729870_ChIP-Seq_TREG_Human1.14276028
88KDM2B_26808549_Chip-Seq_DND41_Human1.13815668
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13775182
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13474070
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.13470817
92* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13324776
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13199633
94SPI1_23127762_ChIP-Seq_K562_Human1.12292466
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.11547358
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11507116
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10801891
98* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10677992
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10677304
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10373965
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10339809
102UTX_26944678_Chip-Seq_JUKART_Human1.09619751
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09355917
104* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09177210
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09031120
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08794728
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08699995
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07557698
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05297913
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04929781
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04784578
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04689359
113MYB_26560356_Chip-Seq_TH1_Human1.04347563
114ZNF263_19887448_ChIP-Seq_K562_Human1.03745020
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02757585
116GATA1_19941826_ChIP-Seq_K562_Human1.02659086
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02623805
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01687016
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00935296
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00513893
121* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99676966
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99635668
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98668170
124MYB_26560356_Chip-Seq_TH2_Human0.96936515
125GATA6_25053715_ChIP-Seq_YYC3_Human0.96692236
126MAF_26560356_Chip-Seq_TH2_Human0.96521297
127* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95596537
128TTF2_22483619_ChIP-Seq_HELA_Human0.95426509
129XRN2_22483619_ChIP-Seq_HELA_Human0.92897010
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91309245
131DCP1A_22483619_ChIP-Seq_HELA_Human0.88604965
132KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86316806
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86145627
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85243247
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83861234
136* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83489605
137SPI1_23547873_ChIP-Seq_NB4_Human0.83148952
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80612201
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80612201
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80507560
141ETS1_20019798_ChIP-Seq_JURKAT_Human0.80332998
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79496450
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79095431
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78829484
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.78765636
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77132367
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77000487
148IRF8_27001747_Chip-Seq_BMDM_Mouse0.76402191
149MYC_18940864_ChIP-ChIP_HL60_Human0.76114164
150MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76039791
151CIITA_25753668_ChIP-Seq_RAJI_Human0.75583654
152KDM5A_27292631_Chip-Seq_BREAST_Human0.74281876
153FUS_26573619_Chip-Seq_HEK293_Human0.73241798
154TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73134806
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.73089007
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73048556
157SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72840667
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71657398
159BRD4_25478319_ChIP-Seq_HGPS_Human0.71581730
160PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71198213
161TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70435529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.06738728
2MP0010094_abnormal_chromosome_stability3.25077281
3MP0003693_abnormal_embryo_hatching3.18533997
4MP0005451_abnormal_body_composition2.97210964
5MP0008007_abnormal_cellular_replicative2.89640599
6MP0003111_abnormal_nucleus_morphology2.86709189
7MP0003705_abnormal_hypodermis_morpholog2.86644217
8MP0008058_abnormal_DNA_repair2.76094025
9MP0003077_abnormal_cell_cycle2.73270314
10MP0008877_abnormal_DNA_methylation2.68361549
11MP0010234_abnormal_vibrissa_follicle2.14430202
12MP0010307_abnormal_tumor_latency2.09681591
13MP0004957_abnormal_blastocyst_morpholog2.08568366
14MP0004233_abnormal_muscle_weight2.07057721
15MP0003300_gastrointestinal_ulcer2.01948492
16MP0002877_abnormal_melanocyte_morpholog1.98774529
17MP0010352_gastrointestinal_tract_polyps1.87608233
18MP0003786_premature_aging1.85371629
19MP0005410_abnormal_fertilization1.83632713
20MP0003091_abnormal_cell_migration1.83513987
21MP0004185_abnormal_adipocyte_glucose1.74860581
22MP0004808_abnormal_hematopoietic_stem1.65195672
23MP0002396_abnormal_hematopoietic_system1.64396614
24MP0003656_abnormal_erythrocyte_physiolo1.63487579
25MP0000350_abnormal_cell_proliferation1.60794156
26MP0005076_abnormal_cell_differentiation1.60634339
27MP0003121_genomic_imprinting1.55796700
28MP0003941_abnormal_skin_development1.55424367
29MP0008932_abnormal_embryonic_tissue1.52964722
30MP0000566_synostosis1.49987182
31MP0002210_abnormal_sex_determination1.49536356
32MP0003787_abnormal_imprinting1.49131933
33MP0003123_paternal_imprinting1.46685027
34MP0004947_skin_inflammation1.45767191
35MP0001929_abnormal_gametogenesis1.43088027
36MP0003453_abnormal_keratinocyte_physiol1.36150452
37MP0000516_abnormal_urinary_system1.33358798
38MP0005367_renal/urinary_system_phenotyp1.33358798
39MP0008260_abnormal_autophagy1.30823070
40MP0001348_abnormal_lacrimal_gland1.28778364
41* MP0001672_abnormal_embryogenesis/_devel1.27295012
42* MP0005380_embryogenesis_phenotype1.27295012
43MP0003763_abnormal_thymus_physiology1.27027228
44MP0006292_abnormal_olfactory_placode1.26632675
45MP0003303_peritoneal_inflammation1.25996336
46MP0003221_abnormal_cardiomyocyte_apopto1.25629794
47* MP0001835_abnormal_antigen_presentation1.25274812
48MP0001545_abnormal_hematopoietic_system1.24960301
49MP0005397_hematopoietic_system_phenotyp1.24960301
50MP0001730_embryonic_growth_arrest1.24353448
51MP0002009_preneoplasia1.23163480
52MP0005621_abnormal_cell_physiology1.22896149
53MP0008438_abnormal_cutaneous_collagen1.20931878
54MP0003984_embryonic_growth_retardation1.16610532
55MP0001145_abnormal_male_reproductive1.15537136
56MP0004264_abnormal_extraembryonic_tissu1.15113875
57MP0009697_abnormal_copulation1.14208225
58MP0002088_abnormal_embryonic_growth/wei1.14111700
59MP0005409_darkened_coat_color1.14053891
60MP0000490_abnormal_crypts_of1.13558728
61MP0003718_maternal_effect1.12925475
62MP0001119_abnormal_female_reproductive1.12847273
63MP0000569_abnormal_digit_pigmentation1.12686699
64MP0004197_abnormal_fetal_growth/weight/1.12227274
65MP0002006_tumorigenesis1.10134887
66MP0000733_abnormal_muscle_development1.09614151
67MP0002086_abnormal_extraembryonic_tissu1.06879720
68MP0002277_abnormal_respiratory_mucosa1.06797089
69MP0000653_abnormal_sex_gland1.06576734
70MP0003315_abnormal_perineum_morphology1.03498941
71MP0002148_abnormal_hypersensitivity_rea1.02391137
72MP0003890_abnormal_embryonic-extraembry1.01040787
73MP0002085_abnormal_embryonic_tissue1.00917797
74MP0003448_altered_tumor_morphology1.00174744
75MP0005666_abnormal_adipose_tissue0.99652250
76* MP0001697_abnormal_embryo_size0.99461845
77MP0003937_abnormal_limbs/digits/tail_de0.99350715
78MP0003191_abnormal_cellular_cholesterol0.99216960
79MP0002405_respiratory_system_inflammati0.98873775
80MP0003698_abnormal_male_reproductive0.98174637
81MP0002060_abnormal_skin_morphology0.98168718
82MP0003828_pulmonary_edema0.97991896
83MP0003566_abnormal_cell_adhesion0.97960778
84MP0001661_extended_life_span0.97633391
85MP0000313_abnormal_cell_death0.97206104
86MP0003136_yellow_coat_color0.96812684
87MP0005671_abnormal_response_to0.95559202
88MP0005023_abnormal_wound_healing0.95336163
89MP0002160_abnormal_reproductive_system0.94894975
90* MP0002398_abnormal_bone_marrow0.94394171
91MP0001873_stomach_inflammation0.94339701
92MP0009333_abnormal_splenocyte_physiolog0.93845211
93MP0002084_abnormal_developmental_patter0.93791426
94MP0010030_abnormal_orbit_morphology0.93503632
95MP0000015_abnormal_ear_pigmentation0.93002136
96MP0002019_abnormal_tumor_incidence0.92910431
97MP0004782_abnormal_surfactant_physiolog0.91755418
98MP0003436_decreased_susceptibility_to0.91506498
99MP0004381_abnormal_hair_follicle0.91331915
100MP0005408_hypopigmentation0.91285741
101MP0000432_abnormal_head_morphology0.90881076
102* MP0002452_abnormal_antigen_presenting0.90659247
103MP0001293_anophthalmia0.89906816
104* MP0001800_abnormal_humoral_immune0.88564330
105MP0001849_ear_inflammation0.88494179
106MP0000703_abnormal_thymus_morphology0.88287959
107MP0005384_cellular_phenotype0.87825401
108MP0005387_immune_system_phenotype0.86293640
109MP0001790_abnormal_immune_system0.86293640
110MP0009785_altered_susceptibility_to0.86129649
111MP0000858_altered_metastatic_potential0.85252922
112MP0000627_abnormal_mammary_gland0.84698604
113MP0003936_abnormal_reproductive_system0.84651085
114MP0003943_abnormal_hepatobiliary_system0.84172627
115MP0001915_intracranial_hemorrhage0.82871422
116MP0005310_abnormal_salivary_gland0.82651785
117MP0005000_abnormal_immune_tolerance0.82183446
118MP0005389_reproductive_system_phenotype0.81905706
119MP0005375_adipose_tissue_phenotype0.81646973
120MP0008995_early_reproductive_senescence0.81162328
121MP0001216_abnormal_epidermal_layer0.80898365
122MP0002163_abnormal_gland_morphology0.80858393
123MP0009278_abnormal_bone_marrow0.80572215
124MP0000689_abnormal_spleen_morphology0.79382929
125* MP0002429_abnormal_blood_cell0.79205987
126MP0001853_heart_inflammation0.77709028
127MP0002080_prenatal_lethality0.77014924
128MP0003172_abnormal_lysosome_physiology0.76928050
129MP0003950_abnormal_plasma_membrane0.76913429
130MP0002166_altered_tumor_susceptibility0.76841025
131MP0001851_eye_inflammation0.76676853
132MP0010630_abnormal_cardiac_muscle0.75726488
133* MP0001819_abnormal_immune_cell0.75346397
134MP0000003_abnormal_adipose_tissue0.75297580
135MP0002722_abnormal_immune_system0.75177633
136* MP0002420_abnormal_adaptive_immunity0.74862567
137* MP0000716_abnormal_immune_system0.74669368
138* MP0002723_abnormal_immune_serum0.74524040
139MP0000685_abnormal_immune_system0.73700759
140MP0002998_abnormal_bone_remodeling0.73170256
141MP0000371_diluted_coat_color0.73068231
142MP0002796_impaired_skin_barrier0.71609073
143MP0002332_abnormal_exercise_endurance0.71348819
144* MP0002419_abnormal_innate_immunity0.71253306

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.49002720
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47225841
3Ectopic kidney (HP:0000086)3.61362193
4Birth length less than 3rd percentile (HP:0003561)3.11133723
5Impulsivity (HP:0100710)3.05016023
6Abnormality of chromosome stability (HP:0003220)2.99843467
7Meckel diverticulum (HP:0002245)2.88949699
8Subacute progressive viral hepatitis (HP:0006572)2.86313575
9Ankyloglossia (HP:0010296)2.84748551
10Abnormality of the fingertips (HP:0001211)2.72333135
11Prostate neoplasm (HP:0100787)2.71622800
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.70651133
13Abnormality of the ileum (HP:0001549)2.69672777
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66403529
15Osteolytic defects of the hand bones (HP:0009699)2.66032087
16Osteolytic defects of the phalanges of the hand (HP:0009771)2.66032087
17Abnormality of the preputium (HP:0100587)2.60799004
18Acute myeloid leukemia (HP:0004808)2.60738542
19Abnormality of oral frenula (HP:0000190)2.58049544
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.56579434
21Abnormality of the nasal septum (HP:0000419)2.52860712
22Syringomyelia (HP:0003396)2.37873702
23Spinal cord lesions (HP:0100561)2.37873702
24Clubbing of toes (HP:0100760)2.37566755
25Increased connective tissue (HP:0009025)2.37485203
26Dysmetric saccades (HP:0000641)2.36652426
27Absent radius (HP:0003974)2.36593043
28Lip pit (HP:0100267)2.36152431
29Nephroblastoma (Wilms tumor) (HP:0002667)2.35974292
3011 pairs of ribs (HP:0000878)2.34859059
31Intestinal fistula (HP:0100819)2.30727114
32Carpal bone hypoplasia (HP:0001498)2.29475082
33Sandal gap (HP:0001852)2.28506225
34Patellar aplasia (HP:0006443)2.28268208
35Insidious onset (HP:0003587)2.27501849
36Termporal pattern (HP:0011008)2.27501849
37Retrobulbar optic neuritis (HP:0100654)2.26364559
38Optic neuritis (HP:0100653)2.26364559
39Myelodysplasia (HP:0002863)2.25847344
40Embryonal renal neoplasm (HP:0011794)2.23138531
41Heterotopia (HP:0002282)2.18925385
42Small intestinal stenosis (HP:0012848)2.18759797
43Duodenal stenosis (HP:0100867)2.18759797
44Absent frontal sinuses (HP:0002688)2.17633641
45Abnormality of the renal collecting system (HP:0004742)2.17253794
46Abnormality of the anterior horn cell (HP:0006802)2.16834608
47Degeneration of anterior horn cells (HP:0002398)2.16834608
48Aplasia involving forearm bones (HP:0009822)2.16171339
49Absent forearm bone (HP:0003953)2.16171339
50Broad face (HP:0000283)2.15927746
51Supernumerary spleens (HP:0009799)2.15026480
52Aplasia/Hypoplasia of the patella (HP:0006498)2.14420540
53Flat acetabular roof (HP:0003180)2.14251144
54Absent thumb (HP:0009777)2.12133633
55Myocardial infarction (HP:0001658)2.10647590
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.10070425
57Absent/shortened dynein arms (HP:0200106)2.10070425
58Duplicated collecting system (HP:0000081)2.09660429
59Relative macrocephaly (HP:0004482)2.08977967
60Sparse lateral eyebrow (HP:0005338)2.07770624
61Hyperacusis (HP:0010780)2.07324941
62Stenosis of the external auditory canal (HP:0000402)2.06882504
63Dislocated radial head (HP:0003083)2.06868965
64Breast hypoplasia (HP:0003187)2.06051397
65Optic nerve coloboma (HP:0000588)2.04055766
66Fatigue (HP:0012378)2.03893569
67Abnormal spermatogenesis (HP:0008669)2.03261421
68Rectovaginal fistula (HP:0000143)2.02661973
69Rectal fistula (HP:0100590)2.02661973
70Deep philtrum (HP:0002002)2.01570773
71Poikiloderma (HP:0001029)1.99871969
72Short thumb (HP:0009778)1.99540880
73Viral hepatitis (HP:0006562)1.99507023
74Urethral obstruction (HP:0000796)1.97797578
75Volvulus (HP:0002580)1.96660889
76Distal lower limb amyotrophy (HP:0008944)1.95955029
77Abnormality of the labia minora (HP:0012880)1.95166452
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94487877
79Short 4th metacarpal (HP:0010044)1.94487877
80Abnormal foot bone ossification (HP:0010675)1.94329967
81Anal stenosis (HP:0002025)1.94118209
82Selective tooth agenesis (HP:0001592)1.93627289
83Sloping forehead (HP:0000340)1.93353228
84Medulloblastoma (HP:0002885)1.92046711
85Long eyelashes (HP:0000527)1.91519586
86Papillary thyroid carcinoma (HP:0002895)1.91154748
87Orthostatic hypotension (HP:0001278)1.90853050
88Abnormal lung lobation (HP:0002101)1.89897262
89Recurrent viral infections (HP:0004429)1.89327646
90Deviation of the thumb (HP:0009603)1.88514160
91Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88425949
92Aplasia/hypoplasia of the humerus (HP:0006507)1.88072966
93Colitis (HP:0002583)1.87144540
94Asymmetry of the thorax (HP:0001555)1.85727582
95Short humerus (HP:0005792)1.83139190
96Orchitis (HP:0100796)1.82940281
97Persistence of primary teeth (HP:0006335)1.82238146
98Slow saccadic eye movements (HP:0000514)1.81525071
99Vertebral arch anomaly (HP:0008438)1.81384646
100Abnormality of incisor morphology (HP:0011063)1.80932718
101Cellulitis (HP:0100658)1.79592484
102Abnormality of the carotid arteries (HP:0005344)1.78901170
103Disproportionate tall stature (HP:0001519)1.78689386
104Uterine leiomyosarcoma (HP:0002891)1.78272769
105Leiomyosarcoma (HP:0100243)1.78272769
106Premature rupture of membranes (HP:0001788)1.77857490
107Ulnar bowing (HP:0003031)1.77590500
108Abnormality of the duodenum (HP:0002246)1.76281393
109Mitral valve prolapse (HP:0001634)1.76108236
110Abnormality of the radial head (HP:0003995)1.75969217
111Amaurosis fugax (HP:0100576)1.75109546
112Short nail (HP:0001799)1.74490888
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74259481
114Progressive hearing impairment (HP:0001730)1.74074807
115Bone marrow hypocellularity (HP:0005528)1.72952934
116Increased nuchal translucency (HP:0010880)1.72437817
117Hepatitis (HP:0012115)1.69675556
118Progressive external ophthalmoplegia (HP:0000590)1.69180671
119Renovascular hypertension (HP:0100817)1.68710029
120Overlapping toe (HP:0001845)1.68424091
121Autoimmune hemolytic anemia (HP:0001890)1.67988132
122Malignant gastrointestinal tract tumors (HP:0006749)1.67594821
123Gastrointestinal carcinoma (HP:0002672)1.67594821
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66516071
125Protrusio acetabuli (HP:0003179)1.66334840
126Hypopigmentation of the fundus (HP:0007894)1.66070758
127Abnormality of the incisor (HP:0000676)1.65650594
128Cafe-au-lait spot (HP:0000957)1.65581383
129Rhinitis (HP:0012384)1.65296820
130Eczematoid dermatitis (HP:0000976)1.64955082
131Neonatal hypoglycemia (HP:0001998)1.64802960
132Keratoconjunctivitis sicca (HP:0001097)1.64528503
133Dilatation of the ascending aorta (HP:0005111)1.64364532
134Transitional cell carcinoma of the bladder (HP:0006740)1.63490882
135Abnormal respiratory motile cilium morphology (HP:0005938)1.62700656
136Abnormal respiratory epithelium morphology (HP:0012253)1.62700656
137Agnosia (HP:0010524)1.61188533
138Triphalangeal thumb (HP:0001199)1.61094032
139Proximal placement of thumb (HP:0009623)1.60607505
140Segmental peripheral demyelination/remyelination (HP:0003481)1.60304549
141Gingivitis (HP:0000230)1.60145276
142Bladder neoplasm (HP:0009725)1.58391965
143Bladder carcinoma (HP:0002862)1.58391965
144Renal cell carcinoma (HP:0005584)1.58281705
145Narrow palate (HP:0000189)1.57427266
146Neoplasm of the tracheobronchial system (HP:0100552)1.57400115
147Entropion (HP:0000621)1.57201345
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56756168
149Stillbirth (HP:0003826)1.56492177
150Resting tremor (HP:0002322)1.56428468
151Periodontitis (HP:0000704)1.56261426
152Supernumerary ribs (HP:0005815)1.55890037
153Abnormality of DNA repair (HP:0003254)1.55475718
154Abnormality of the distal phalanges of the toes (HP:0010182)1.54374469
155Low anterior hairline (HP:0000294)1.53890598
156Cerebral aneurysm (HP:0004944)1.53560662
157T lymphocytopenia (HP:0005403)1.53111979
158Decreased motor nerve conduction velocity (HP:0003431)1.52904657
159Flat capital femoral epiphysis (HP:0003370)1.52315508
160Abnormal respiratory motile cilium physiology (HP:0012261)1.52165786
161Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.52130384
162Centrally nucleated skeletal muscle fibers (HP:0003687)1.51787723
163Azoospermia (HP:0000027)1.51704208
164Advanced eruption of teeth (HP:0006288)1.51694764
165Micronodular cirrhosis (HP:0001413)1.51233203
166Cubitus valgus (HP:0002967)1.51146957
167Myositis (HP:0100614)1.51028608
168Abnormality of chromosome segregation (HP:0002916)1.50639305
169Keratoconjunctivitis (HP:0001096)1.50453529
170Vaginal fistula (HP:0004320)1.50358186
171Aneurysm (HP:0002617)1.50112611
172Stomach cancer (HP:0012126)1.49672644
173IgA deficiency (HP:0002720)1.49237340
174Missing ribs (HP:0000921)1.49131964
175Abnormality of the distal phalanx of the thumb (HP:0009617)1.48988692
176Supernumerary bones of the axial skeleton (HP:0009144)1.48934952
177Shawl scrotum (HP:0000049)1.48833620
178Long palpebral fissure (HP:0000637)1.48483553
179Coarse hair (HP:0002208)1.47943417
180Abnormality of the columella (HP:0009929)1.47811426
181Abnormality of the thoracic spine (HP:0100711)1.47784808
182Somatic mutation (HP:0001428)1.47672815
183Vertebral compression fractures (HP:0002953)1.47621866
184Prominent nose (HP:0000448)1.46675000
185Alveolar cell carcinoma (HP:0006519)1.46631762
186Neoplasm of the oral cavity (HP:0100649)1.45660437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.42154738
2ICK3.24225991
3EEF2K2.93027364
4ZAK2.86427725
5TRIB32.85080946
6PLK42.73337554
7SRPK12.73109273
8CDC72.67888335
9BRSK22.66640161
10SMG12.65430825
11PRPF4B2.62830753
12MAP3K142.60663577
13MKNK22.45676452
14STK38L2.32907027
15MKNK12.23929538
16MST1R2.05467801
17IRAK31.99444127
18LATS11.98103528
19SCYL21.96172731
20TTK1.95806223
21WEE11.91466269
22STK31.85507606
23NEK21.72425576
24PLK31.71428817
25MAP2K31.67838350
26NUAK11.67825966
27TTN1.66402834
28JAK31.61492519
29MAP3K101.60596669
30ATR1.60032784
31CHUK1.59761750
32PIM11.58873216
33CAMK1D1.57070294
34KSR21.56433446
35BRD41.50498325
36TXK1.49069325
37ERN11.48554044
38CAMK1G1.47927122
39CHEK21.47711533
40STK41.47383609
41VRK11.46750186
42STK101.46492418
43IRAK41.44685845
44FGFR41.40043092
45PLK11.39424842
46PASK1.36586074
47EIF2AK21.36507130
48AKT31.34453480
49IKBKB1.34029211
50MAP3K21.29945433
51STK241.29061354
52PDGFRA1.27964259
53BUB11.26516350
54EPHA21.25839264
55CLK11.21788958
56EIF2AK11.21259158
57CHEK11.20254371
58ATM1.16626840
59TSSK61.16537171
60AURKB1.14179622
61CDK71.13200729
62LATS21.13119135
63TESK11.06965474
64MAP3K131.03452548
65ACVR1B1.03277635
66FRK1.02086285
67WNK11.00516342
68RPS6KA40.99564635
69MARK30.98157915
70NEK90.97278470
71PBK0.96432101
72MELK0.90195960
73EIF2AK30.87765011
74RIPK10.87408820
75SIK10.85759686
76MST40.84644150
77MAPK110.83417912
78MET0.82697032
79TRPM70.82597089
80BMPR20.82031465
81IKBKE0.81735540
82ERBB30.81501995
83MAP3K10.81292128
84BRSK10.80919665
85CDK60.80723018
86PAK40.79367569
87RPS6KB20.79350961
88MUSK0.77486914
89RAF10.77213325
90EPHA30.77055590
91NLK0.76299713
92PDK20.72275257
93FGFR30.72012849
94CDK90.70764840
95TEC0.70425828
96MAP3K80.70336509
97CDK40.69700201
98RPS6KA50.69354362
99* CDK20.67440443
100TAOK20.67227276
101STK380.65954742
102CDK80.65867275
103PDGFRB0.65466008
104SGK20.64018118
105MAP3K60.63943090
106TYK20.60690478
107KSR10.57291023
108TGFBR10.56780837
109TLK10.55276067
110MAP3K30.54730652
111* CDK10.54631661
112BRAF0.54405074
113PKN20.53794360
114RET0.53365934
115PIM20.52904502
116CDK30.52647834
117EPHB10.52542818
118BMX0.52072399
119PIK3CG0.51956730
120BTK0.51876558
121BMPR1B0.51550474
122PDPK10.51533415
123ZAP700.50228809
124PRKD30.49571638
125YES10.49484691
126RIPK40.48096087
127PDK40.48007343
128PDK30.48007343
129RPS6KB10.47411314
130MARK20.46851334
131TGFBR20.45812732
132CSK0.45542336
133PTK60.44426749
134AKT10.44089135
135CSNK2A10.44052229
136JAK20.43864700
137ERBB40.43859973
138PTK20.41339075
139PRKAA20.40759220
140MAP4K10.40492316
141IRAK10.39661651
142SGK30.39372686
143MTOR0.38519650
144* MAPK140.38489894
145JAK10.36229537
146MAPKAPK20.35956087
147AURKA0.35574110
148MAPK10.34867312
149ALK0.34823223

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.95237372
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88933811
3Mismatch repair_Homo sapiens_hsa034302.79271162
4Fanconi anemia pathway_Homo sapiens_hsa034602.74717929
5Homologous recombination_Homo sapiens_hsa034402.60555204
6Cell cycle_Homo sapiens_hsa041102.48690397
7Basal transcription factors_Homo sapiens_hsa030222.29118852
8* RNA transport_Homo sapiens_hsa030132.27861036
9RNA polymerase_Homo sapiens_hsa030202.16078836
10Base excision repair_Homo sapiens_hsa034102.07606362
11One carbon pool by folate_Homo sapiens_hsa006702.06031651
12Spliceosome_Homo sapiens_hsa030402.04791751
13RNA degradation_Homo sapiens_hsa030182.02585119
14Non-homologous end-joining_Homo sapiens_hsa034502.01203779
15Non-small cell lung cancer_Homo sapiens_hsa052232.00743142
16Nucleotide excision repair_Homo sapiens_hsa034201.90989608
17p53 signaling pathway_Homo sapiens_hsa041151.87675600
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.76975012
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75358511
20Herpes simplex infection_Homo sapiens_hsa051681.65318906
21mRNA surveillance pathway_Homo sapiens_hsa030151.64547038
22Measles_Homo sapiens_hsa051621.48402518
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47734003
24Graft-versus-host disease_Homo sapiens_hsa053321.47595327
25Endometrial cancer_Homo sapiens_hsa052131.42328569
26Bladder cancer_Homo sapiens_hsa052191.42097940
27Pyrimidine metabolism_Homo sapiens_hsa002401.41627547
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.38383390
29Allograft rejection_Homo sapiens_hsa053301.37825238
30Antigen processing and presentation_Homo sapiens_hsa046121.36572272
31Renal cell carcinoma_Homo sapiens_hsa052111.36507538
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32759857
33Epstein-Barr virus infection_Homo sapiens_hsa051691.30948705
34MicroRNAs in cancer_Homo sapiens_hsa052061.29762705
35Colorectal cancer_Homo sapiens_hsa052101.29261276
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28287081
37Viral carcinogenesis_Homo sapiens_hsa052031.27767310
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.25884166
39mTOR signaling pathway_Homo sapiens_hsa041501.22013077
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20204990
41Systemic lupus erythematosus_Homo sapiens_hsa053221.18448966
42Legionellosis_Homo sapiens_hsa051341.17085462
43Lysine degradation_Homo sapiens_hsa003101.17020911
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16873999
45Glioma_Homo sapiens_hsa052141.16645109
46VEGF signaling pathway_Homo sapiens_hsa043701.15593678
47* Influenza A_Homo sapiens_hsa051641.14561606
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14130267
49HTLV-I infection_Homo sapiens_hsa051661.09691983
50Inositol phosphate metabolism_Homo sapiens_hsa005621.08154025
51Autoimmune thyroid disease_Homo sapiens_hsa053201.07991105
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07375103
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05211675
54Small cell lung cancer_Homo sapiens_hsa052221.03112275
55ErbB signaling pathway_Homo sapiens_hsa040121.02107488
56Fatty acid biosynthesis_Homo sapiens_hsa000610.99994429
57Other glycan degradation_Homo sapiens_hsa005110.97600867
58Focal adhesion_Homo sapiens_hsa045100.97564550
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97020832
60Leishmaniasis_Homo sapiens_hsa051400.95702025
61TGF-beta signaling pathway_Homo sapiens_hsa043500.94934596
62Purine metabolism_Homo sapiens_hsa002300.94536768
63Hematopoietic cell lineage_Homo sapiens_hsa046400.94326082
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.93807101
65Proteasome_Homo sapiens_hsa030500.93797739
66TNF signaling pathway_Homo sapiens_hsa046680.93695408
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93235145
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.91103915
69Adherens junction_Homo sapiens_hsa045200.87484495
70Hepatitis B_Homo sapiens_hsa051610.87010667
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86856133
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85036902
73Asthma_Homo sapiens_hsa053100.84724623
74Apoptosis_Homo sapiens_hsa042100.83955251
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83562072
76Primary immunodeficiency_Homo sapiens_hsa053400.82793805
77Prostate cancer_Homo sapiens_hsa052150.81289464
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81146779
79Insulin signaling pathway_Homo sapiens_hsa049100.80467882
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80397003
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.80325088
82Notch signaling pathway_Homo sapiens_hsa043300.79706875
83Malaria_Homo sapiens_hsa051440.79021305
84Toxoplasmosis_Homo sapiens_hsa051450.77980176
85Choline metabolism in cancer_Homo sapiens_hsa052310.74939237
86Viral myocarditis_Homo sapiens_hsa054160.74284083
87Insulin resistance_Homo sapiens_hsa049310.73517763
88Pentose phosphate pathway_Homo sapiens_hsa000300.73009303
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.71955582
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71866461
91Amoebiasis_Homo sapiens_hsa051460.67450577
92Arachidonic acid metabolism_Homo sapiens_hsa005900.67136250
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66532331
94Type I diabetes mellitus_Homo sapiens_hsa049400.66165522
95Thyroid cancer_Homo sapiens_hsa052160.66148811
96Platelet activation_Homo sapiens_hsa046110.65280991
97Osteoclast differentiation_Homo sapiens_hsa043800.61080624
98Acute myeloid leukemia_Homo sapiens_hsa052210.59504574
99Basal cell carcinoma_Homo sapiens_hsa052170.58513293
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.57291528
101Pathways in cancer_Homo sapiens_hsa052000.56408615
102Type II diabetes mellitus_Homo sapiens_hsa049300.55466621
103Tuberculosis_Homo sapiens_hsa051520.54836227
104Oocyte meiosis_Homo sapiens_hsa041140.54666722
105Chronic myeloid leukemia_Homo sapiens_hsa052200.54192334
106AMPK signaling pathway_Homo sapiens_hsa041520.53553202
107Hippo signaling pathway_Homo sapiens_hsa043900.52816203
108T cell receptor signaling pathway_Homo sapiens_hsa046600.52705997
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52606887
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52558242
111ECM-receptor interaction_Homo sapiens_hsa045120.51928717
112Selenocompound metabolism_Homo sapiens_hsa004500.51588438
113Estrogen signaling pathway_Homo sapiens_hsa049150.51510544
114Shigellosis_Homo sapiens_hsa051310.51114685
115FoxO signaling pathway_Homo sapiens_hsa040680.50073493
116Biosynthesis of amino acids_Homo sapiens_hsa012300.49471634
117Ribosome_Homo sapiens_hsa030100.48857885
118B cell receptor signaling pathway_Homo sapiens_hsa046620.44922094
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43995152
120HIF-1 signaling pathway_Homo sapiens_hsa040660.43516909
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42382733
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.40596069
123Melanoma_Homo sapiens_hsa052180.40372881
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40135100
125Hepatitis C_Homo sapiens_hsa051600.39373451
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39150542
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37365378
128Prolactin signaling pathway_Homo sapiens_hsa049170.37103666
129Proteoglycans in cancer_Homo sapiens_hsa052050.37001808
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36211623
131Pancreatic cancer_Homo sapiens_hsa052120.35540573
132Salmonella infection_Homo sapiens_hsa051320.34729165
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34410328
134Dorso-ventral axis formation_Homo sapiens_hsa043200.34189086
135Linoleic acid metabolism_Homo sapiens_hsa005910.33268731
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32683195

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