NUPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.53226881
2DNA strand elongation involved in DNA replication (GO:0006271)4.44802983
3DNA strand elongation (GO:0022616)4.35775185
4DNA replication initiation (GO:0006270)4.35344521
5telomere maintenance via semi-conservative replication (GO:0032201)4.30723727
6response to pheromone (GO:0019236)4.23616043
7respiratory chain complex IV assembly (GO:0008535)4.02820242
8nucleobase biosynthetic process (GO:0046112)3.96224733
9binding of sperm to zona pellucida (GO:0007339)3.88736078
10sperm-egg recognition (GO:0035036)3.88674250
11pseudouridine synthesis (GO:0001522)3.87240691
12mitotic metaphase plate congression (GO:0007080)3.82654007
13protein localization to chromosome, centromeric region (GO:0071459)3.80626120
14telomere maintenance via recombination (GO:0000722)3.80518301
15telomere maintenance via telomere lengthening (GO:0010833)3.77185984
16IMP biosynthetic process (GO:0006188)3.75847158
17purine nucleobase biosynthetic process (GO:0009113)3.74255951
18protein complex biogenesis (GO:0070271)3.71965007
19* mitotic nuclear envelope disassembly (GO:0007077)3.71141116
20intra-S DNA damage checkpoint (GO:0031573)3.71114200
21fusion of sperm to egg plasma membrane (GO:0007342)3.68893203
22nucleotide-excision repair, DNA gap filling (GO:0006297)3.68799623
23protein localization to kinetochore (GO:0034501)3.68200454
24translesion synthesis (GO:0019985)3.64598960
25kinetochore organization (GO:0051383)3.64353724
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.63407763
27NADH dehydrogenase complex assembly (GO:0010257)3.63407763
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63407763
29mitochondrial respiratory chain complex assembly (GO:0033108)3.58703687
30mitotic recombination (GO:0006312)3.55179746
31kinetochore assembly (GO:0051382)3.54872750
32DNA replication-dependent nucleosome assembly (GO:0006335)3.53914737
33DNA replication-dependent nucleosome organization (GO:0034723)3.53914737
34cytochrome complex assembly (GO:0017004)3.53493332
35chromatin remodeling at centromere (GO:0031055)3.51679020
36cilium or flagellum-dependent cell motility (GO:0001539)3.51565223
37CENP-A containing nucleosome assembly (GO:0034080)3.49583006
38DNA replication checkpoint (GO:0000076)3.48253630
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47556493
40folic acid-containing compound biosynthetic process (GO:0009396)3.46246102
41regulation of cilium movement (GO:0003352)3.46181581
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44611921
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.43871282
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.42776691
45motile cilium assembly (GO:0044458)3.42042676
46cell-cell recognition (GO:0009988)3.41820696
47spliceosomal snRNP assembly (GO:0000387)3.41159699
48DNA replication-independent nucleosome organization (GO:0034724)3.40816513
49DNA replication-independent nucleosome assembly (GO:0006336)3.40816513
50* nuclear envelope disassembly (GO:0051081)3.40408502
51* membrane disassembly (GO:0030397)3.40408502
52folic acid metabolic process (GO:0046655)3.39082305
53metaphase plate congression (GO:0051310)3.34656348
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33463811
55histone exchange (GO:0043486)3.32681584
56ribosome biogenesis (GO:0042254)3.31375404
57water-soluble vitamin biosynthetic process (GO:0042364)3.29345353
58formation of translation preinitiation complex (GO:0001731)3.27574640
59behavioral response to nicotine (GO:0035095)3.25518006
60IMP metabolic process (GO:0046040)3.24653305
61recombinational repair (GO:0000725)3.24301907
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22781023
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22781023
64double-strand break repair via homologous recombination (GO:0000724)3.22464322
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.19983073
66ATP synthesis coupled proton transport (GO:0015986)3.19377659
67energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19377659
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17709718
69regulation of mitotic spindle checkpoint (GO:1903504)3.17709718
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17264427
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17256207
72DNA unwinding involved in DNA replication (GO:0006268)3.17040921
73single strand break repair (GO:0000012)3.12629987
74DNA double-strand break processing (GO:0000729)3.12612624
75telomere organization (GO:0032200)3.11801285
76axonemal dynein complex assembly (GO:0070286)3.07823980
77cell wall macromolecule catabolic process (GO:0016998)3.07659793
78cell wall macromolecule metabolic process (GO:0044036)3.07659793
79synapsis (GO:0007129)3.07547192
80telomere maintenance (GO:0000723)3.07446474
81DNA strand renaturation (GO:0000733)3.06988012
82nuclear pore complex assembly (GO:0051292)3.05361424
83nuclear pore organization (GO:0006999)3.04629068
84DNA packaging (GO:0006323)3.03325062
85acrosome reaction (GO:0007340)3.02597425
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02198465
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02064824
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.01704605
89cullin deneddylation (GO:0010388)3.00862205
90sperm motility (GO:0030317)2.99385820
91protein-cofactor linkage (GO:0018065)2.98280808
92meiotic chromosome segregation (GO:0045132)2.97457737
93piRNA metabolic process (GO:0034587)2.97230035
94maturation of SSU-rRNA (GO:0030490)2.96330578
95mitotic sister chromatid cohesion (GO:0007064)2.95221821
96DNA-dependent DNA replication (GO:0006261)2.95190066
97postreplication repair (GO:0006301)2.95078033
98proteasome assembly (GO:0043248)2.94852109
99peptidyl-histidine modification (GO:0018202)2.90927365
100regulation of mitochondrial translation (GO:0070129)2.90883108
101tRNA processing (GO:0008033)2.90854995
102neural tube formation (GO:0001841)2.90673333
103rRNA catabolic process (GO:0016075)2.89554484
104cellular ketone body metabolic process (GO:0046950)2.89048587
105chromosome condensation (GO:0030261)2.88856787
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87635272
107DNA catabolic process, exonucleolytic (GO:0000738)2.87485282
108somatic hypermutation of immunoglobulin genes (GO:0016446)2.86958757
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86958757
110pore complex assembly (GO:0046931)2.86515916
111establishment of chromosome localization (GO:0051303)2.85781620
112mismatch repair (GO:0006298)2.85058880
113platelet dense granule organization (GO:0060155)2.84833344
114mitochondrial RNA metabolic process (GO:0000959)2.84093506
115ribosome assembly (GO:0042255)2.82298911
116snRNA processing (GO:0016180)2.81566676
117L-fucose catabolic process (GO:0042355)2.81146488
118fucose catabolic process (GO:0019317)2.81146488
119L-fucose metabolic process (GO:0042354)2.81146488
120transcription elongation from RNA polymerase III promoter (GO:0006385)2.80694501
121termination of RNA polymerase III transcription (GO:0006386)2.80694501
122rRNA modification (GO:0000154)2.80241084
123maturation of 5.8S rRNA (GO:0000460)2.79654292
124monoubiquitinated protein deubiquitination (GO:0035520)2.79592097
125resolution of meiotic recombination intermediates (GO:0000712)2.78530247
126RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77372880
127reciprocal meiotic recombination (GO:0007131)2.77263344
128reciprocal DNA recombination (GO:0035825)2.77263344
129protein K6-linked ubiquitination (GO:0085020)2.77225137
130histone H2A acetylation (GO:0043968)2.77029421
131transcription-coupled nucleotide-excision repair (GO:0006283)2.76786378
132preassembly of GPI anchor in ER membrane (GO:0016254)2.76578337
133negative regulation of telomere maintenance (GO:0032205)2.76181040
134protein deneddylation (GO:0000338)2.74535715
135establishment of protein localization to mitochondrial membrane (GO:0090151)2.74357498
136rRNA processing (GO:0006364)2.73607831
137nonmotile primary cilium assembly (GO:0035058)2.73279986
138ribonucleoprotein complex biogenesis (GO:0022613)2.73246329
139deoxyribonucleotide biosynthetic process (GO:0009263)2.73076704
140DNA replication (GO:0006260)2.72753714
141protein polyglutamylation (GO:0018095)2.72683448
142replication fork processing (GO:0031297)2.72324523
143electron transport chain (GO:0022900)2.72289873
144synaptonemal complex assembly (GO:0007130)2.71649144
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71404534
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71404534
147negative regulation of sister chromatid segregation (GO:0033046)2.71404534
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.71404534
149regulation of centrosome cycle (GO:0046605)2.71057288
150negative regulation of chromosome segregation (GO:0051985)2.70967408
151meiotic nuclear division (GO:0007126)2.70506211
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69947884
153anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69513304
154negative regulation of DNA-dependent DNA replication (GO:2000104)2.69259227
155respiratory electron transport chain (GO:0022904)2.68524930
156centriole replication (GO:0007099)2.67636874
157regulation of meiosis I (GO:0060631)2.66685360
158indole-containing compound catabolic process (GO:0042436)2.65506471
159indolalkylamine catabolic process (GO:0046218)2.65506471
160tryptophan catabolic process (GO:0006569)2.65506471
161ubiquinone biosynthetic process (GO:0006744)2.65339666
162ketone body metabolic process (GO:1902224)2.64933606
163attachment of spindle microtubules to kinetochore (GO:0008608)2.63613144
164epithelial cilium movement (GO:0003351)2.61853006
165DNA methylation involved in gamete generation (GO:0043046)2.58876219
166mannosylation (GO:0097502)2.58528718
167sulfation (GO:0051923)2.57188499
168histone mRNA metabolic process (GO:0008334)2.54546407
169regulation of DNA endoreduplication (GO:0032875)2.54062786
170ubiquinone metabolic process (GO:0006743)2.53757062
171protein neddylation (GO:0045116)2.53451329
172indolalkylamine metabolic process (GO:0006586)2.52067141
173tRNA metabolic process (GO:0006399)2.50196189
174detection of light stimulus involved in visual perception (GO:0050908)2.49240814
175detection of light stimulus involved in sensory perception (GO:0050962)2.49240814
176chaperone-mediated protein transport (GO:0072321)2.49138122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55019779
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.40747591
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.07030352
4ZNF274_21170338_ChIP-Seq_K562_Hela3.67035896
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45635169
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43262252
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18409978
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09270524
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.03941645
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99472340
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.85538226
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82256293
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.76589940
14VDR_22108803_ChIP-Seq_LS180_Human2.75621084
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67447476
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.63540920
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61316505
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55853315
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53282439
20EWS_26573619_Chip-Seq_HEK293_Human2.36615418
21IGF1R_20145208_ChIP-Seq_DFB_Human2.34870070
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33857312
23FUS_26573619_Chip-Seq_HEK293_Human2.31981625
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15799417
25AR_21909140_ChIP-Seq_LNCAP_Human2.14836977
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14506603
27XRN2_22483619_ChIP-Seq_HELA_Human2.13052552
28* VDR_23849224_ChIP-Seq_CD4+_Human2.12480929
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11671028
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10365864
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05555437
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02176134
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00020407
34EZH2_22144423_ChIP-Seq_EOC_Human1.99017371
35FOXP3_21729870_ChIP-Seq_TREG_Human1.98703948
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98123358
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96757026
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96641094
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89099085
40GABP_19822575_ChIP-Seq_HepG2_Human1.87005959
41TAF15_26573619_Chip-Seq_HEK293_Human1.85981404
42* E2F1_21310950_ChIP-Seq_MCF-7_Human1.85688684
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.82614843
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82319689
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81692828
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.80976770
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79447784
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78646290
49DCP1A_22483619_ChIP-Seq_HELA_Human1.76311997
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74609078
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73689416
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72271748
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.72026542
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71821457
55* TTF2_22483619_ChIP-Seq_HELA_Human1.69876580
56CIITA_25753668_ChIP-Seq_RAJI_Human1.69860003
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68458944
58P300_19829295_ChIP-Seq_ESCs_Human1.66950615
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63540924
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63539481
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62806679
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62445885
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61446048
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59831733
65ER_23166858_ChIP-Seq_MCF-7_Human1.59817673
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58118896
67GBX2_23144817_ChIP-Seq_PC3_Human1.58000206
68TP53_22573176_ChIP-Seq_HFKS_Human1.54926139
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53091020
70* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47464699
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46946907
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46714760
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45422913
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43322723
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40843858
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40514754
77CBP_20019798_ChIP-Seq_JUKART_Human1.40514754
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37740969
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37165781
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36839202
81KDM5A_27292631_Chip-Seq_BREAST_Human1.31989415
82ELK1_19687146_ChIP-ChIP_HELA_Human1.31914696
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29098390
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.27946306
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27859750
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27034623
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27004854
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23941802
89MYC_22102868_ChIP-Seq_BL_Human1.23158750
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21335113
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21179474
92NANOG_19829295_ChIP-Seq_ESCs_Human1.20701126
93SOX2_19829295_ChIP-Seq_ESCs_Human1.20701126
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19704210
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19617502
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17632061
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17312936
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15856151
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.15789683
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15789683
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15164887
102TFEB_21752829_ChIP-Seq_HELA_Human1.14440361
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11410475
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06316310
105STAT3_23295773_ChIP-Seq_U87_Human1.06073583
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05763002
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05763002
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05479060
109* AR_20517297_ChIP-Seq_VCAP_Human1.04928324
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04558701
111BCAT_22108803_ChIP-Seq_LS180_Human1.04123777
112TCF4_22108803_ChIP-Seq_LS180_Human1.03115051
113AR_25329375_ChIP-Seq_VCAP_Human1.01916786
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01035477
115RNF2_27304074_Chip-Seq_NSC_Mouse1.00699748
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.00372896
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00316257
118* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99358596
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98054572
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97725583
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97646343
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97286406
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.97075253
124NCOR_22424771_ChIP-Seq_293T_Human0.95896539
125TCF4_23295773_ChIP-Seq_U87_Human0.95560184
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95135655
127* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95118325
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94935533
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.94307723
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94149016
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.93875203
132SMAD4_21799915_ChIP-Seq_A2780_Human0.93765040
133EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93542616
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92372859
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92353419
136SPI1_23547873_ChIP-Seq_NB4_Human0.92270103
137* GATA3_21878914_ChIP-Seq_MCF-7_Human0.92111133
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91601527
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90268720
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90261065
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.89939065
142* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89841782
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89565515
144* HOXB7_26014856_ChIP-Seq_BT474_Human0.89412318
145RUNX2_22187159_ChIP-Seq_PCA_Human0.89290209
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88814958
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87767102
148EGR1_19374776_ChIP-ChIP_THP-1_Human0.87468282
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85410363
150NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84933587
151* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84835152
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84783365
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83610068
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82679024
155VDR_21846776_ChIP-Seq_THP-1_Human0.81237865
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79166236
157CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79040517
158CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75833592
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74685966
160MYC_18940864_ChIP-ChIP_HL60_Human0.73896194
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.72538449
162IRF1_19129219_ChIP-ChIP_H3396_Human0.70381796
163GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70179241
164FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69667994
165SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.68500175
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67556586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.15372014
2MP0010094_abnormal_chromosome_stability5.08699906
3MP0003111_abnormal_nucleus_morphology4.95749666
4MP0008058_abnormal_DNA_repair4.50352070
5MP0005410_abnormal_fertilization3.88605126
6MP0003077_abnormal_cell_cycle3.58443318
7MP0004957_abnormal_blastocyst_morpholog3.53250815
8MP0002396_abnormal_hematopoietic_system3.17494437
9MP0008057_abnormal_DNA_replication3.07557078
10MP0008877_abnormal_DNA_methylation2.89566334
11MP0008007_abnormal_cellular_replicative2.79667790
12MP0002102_abnormal_ear_morphology2.40103215
13MP0003195_calcinosis2.32843831
14MP0001929_abnormal_gametogenesis2.21376441
15MP0005551_abnormal_eye_electrophysiolog2.18485575
16MP0000372_irregular_coat_pigmentation2.15624894
17MP0005645_abnormal_hypothalamus_physiol2.14586497
18MP0008932_abnormal_embryonic_tissue2.10514505
19MP0006072_abnormal_retinal_apoptosis2.03027926
20MP0003698_abnormal_male_reproductive2.00840750
21MP0000490_abnormal_crypts_of1.99061922
22MP0002837_dystrophic_cardiac_calcinosis1.95242787
23MP0001730_embryonic_growth_arrest1.89665977
24MP0005670_abnormal_white_adipose1.86150441
25MP0000358_abnormal_cell_content/1.84346083
26MP0003806_abnormal_nucleotide_metabolis1.82706776
27MP0003136_yellow_coat_color1.81611303
28MP0001968_abnormal_touch/_nociception1.81341609
29MP0005397_hematopoietic_system_phenotyp1.80973441
30MP0001545_abnormal_hematopoietic_system1.80973441
31MP0001986_abnormal_taste_sensitivity1.76526735
32MP0000350_abnormal_cell_proliferation1.76429862
33MP0002210_abnormal_sex_determination1.74687573
34MP0008872_abnormal_physiological_respon1.70211093
35MP0005253_abnormal_eye_physiology1.66995029
36MP0008260_abnormal_autophagy1.64286573
37MP0003787_abnormal_imprinting1.64056221
38MP0009046_muscle_twitch1.61032867
39MP0003718_maternal_effect1.56950808
40MP0001145_abnormal_male_reproductive1.56310260
41MP0010352_gastrointestinal_tract_polyps1.54649028
42MP0004043_abnormal_pH_regulation1.54350994
43MP0002736_abnormal_nociception_after1.53849717
44MP0004142_abnormal_muscle_tone1.53610584
45MP0006035_abnormal_mitochondrial_morpho1.53081288
46MP0000313_abnormal_cell_death1.52941489
47MP0003786_premature_aging1.50597723
48MP0009745_abnormal_behavioral_response1.50045433
49MP0004808_abnormal_hematopoietic_stem1.48295642
50MP0010307_abnormal_tumor_latency1.45458758
51MP0002653_abnormal_ependyma_morphology1.44906059
52MP0001697_abnormal_embryo_size1.44636436
53MP0003880_abnormal_central_pattern1.44237958
54MP0005646_abnormal_pituitary_gland1.43221664
55MP0009697_abnormal_copulation1.41910258
56MP0003890_abnormal_embryonic-extraembry1.39909109
57MP0008875_abnormal_xenobiotic_pharmacok1.39785804
58MP0001672_abnormal_embryogenesis/_devel1.38242357
59MP0005380_embryogenesis_phenotype1.38242357
60MP0003646_muscle_fatigue1.35729931
61MP0004133_heterotaxia1.35610186
62MP0000427_abnormal_hair_cycle1.35177837
63MP0000631_abnormal_neuroendocrine_gland1.34741141
64MP0004147_increased_porphyrin_level1.33398086
65MP0003221_abnormal_cardiomyocyte_apopto1.33291839
66MP0002735_abnormal_chemical_nociception1.31115972
67MP0003656_abnormal_erythrocyte_physiolo1.30881292
68MP0002080_prenatal_lethality1.30108533
69MP0002132_abnormal_respiratory_system1.30083015
70MP0000653_abnormal_sex_gland1.29005439
71MP0000015_abnormal_ear_pigmentation1.28458795
72MP0002272_abnormal_nervous_system1.28080325
73MP0003011_delayed_dark_adaptation1.27847846
74MP0002163_abnormal_gland_morphology1.24528285
75MP0002161_abnormal_fertility/fecundity1.24222647
76MP0003984_embryonic_growth_retardation1.23631443
77MP0002019_abnormal_tumor_incidence1.23625315
78MP0002234_abnormal_pharynx_morphology1.23226404
79MP0003123_paternal_imprinting1.19791800
80MP0002088_abnormal_embryonic_growth/wei1.18626886
81MP0001764_abnormal_homeostasis1.17018042
82MP0001529_abnormal_vocalization1.16670929
83MP0005174_abnormal_tail_pigmentation1.14497337
84MP0005084_abnormal_gallbladder_morpholo1.14402397
85MP0003186_abnormal_redox_activity1.14116601
86MP0006292_abnormal_olfactory_placode1.13791885
87MP0006276_abnormal_autonomic_nervous1.12298372
88MP0002085_abnormal_embryonic_tissue1.11530900
89MP0001485_abnormal_pinna_reflex1.11490222
90MP0004233_abnormal_muscle_weight1.10449786
91MP0006036_abnormal_mitochondrial_physio1.10168222
92MP0001293_anophthalmia1.08425087
93MP0005384_cellular_phenotype1.06855084
94MP0005379_endocrine/exocrine_gland_phen1.05342526
95MP0005075_abnormal_melanosome_morpholog1.04874642
96MP0002269_muscular_atrophy1.04710684
97MP0009333_abnormal_splenocyte_physiolog1.04017527
98MP0004885_abnormal_endolymph1.01815763
99MP0005195_abnormal_posterior_eye1.00856578
100MP0002398_abnormal_bone_marrow0.99849080
101MP0001905_abnormal_dopamine_level0.98975197
102MP0002751_abnormal_autonomic_nervous0.97884757
103MP0008789_abnormal_olfactory_epithelium0.97750353
104MP0002084_abnormal_developmental_patter0.96009614
105MP0002928_abnormal_bile_duct0.95689272
106MP0005171_absent_coat_pigmentation0.95184717
107MP0005332_abnormal_amino_acid0.94586012
108MP0001486_abnormal_startle_reflex0.93733791
109MP0002557_abnormal_social/conspecific_i0.91874790
110MP0001873_stomach_inflammation0.91326470
111MP0002086_abnormal_extraembryonic_tissu0.91091095
112MP0003252_abnormal_bile_duct0.91076121
113MP0002160_abnormal_reproductive_system0.89890841
114MP0010386_abnormal_urinary_bladder0.89794372
115MP0002095_abnormal_skin_pigmentation0.88973905
116MP0002733_abnormal_thermal_nociception0.87871262
117MP0004742_abnormal_vestibular_system0.87256833
118MP0003121_genomic_imprinting0.86715032
119MP0003763_abnormal_thymus_physiology0.86254420
120MP0001324_abnormal_eye_pigmentation0.85864291
121MP0001970_abnormal_pain_threshold0.85291100
122MP0000703_abnormal_thymus_morphology0.85130452
123MP0000689_abnormal_spleen_morphology0.84793866
124MP0003122_maternal_imprinting0.84657118
125MP0002572_abnormal_emotion/affect_behav0.83774841
126MP0002722_abnormal_immune_system0.83238498
127MP0002067_abnormal_sensory_capabilities0.83001847
128MP0002064_seizures0.80812197
129MP0005621_abnormal_cell_physiology0.80202418
130MP0009278_abnormal_bone_marrow0.79966368
131MP0001919_abnormal_reproductive_system0.79632391
132MP0002876_abnormal_thyroid_physiology0.79267475
133MP0002429_abnormal_blood_cell0.79266438
134MP0000516_abnormal_urinary_system0.77409039
135MP0005367_renal/urinary_system_phenotyp0.77409039
136MP0002089_abnormal_postnatal_growth/wei0.77406704
137MP0003937_abnormal_limbs/digits/tail_de0.77399436
138MP0000569_abnormal_digit_pigmentation0.72521915
139MP0004197_abnormal_fetal_growth/weight/0.72036603
140MP0009672_abnormal_birth_weight0.68735181
141MP0003567_abnormal_fetal_cardiomyocyte0.67786330
142MP0001119_abnormal_female_reproductive0.67381593
143MP0010030_abnormal_orbit_morphology0.66608655
144MP0005389_reproductive_system_phenotype0.62472486
145MP0002405_respiratory_system_inflammati0.60957109
146MP0000716_abnormal_immune_system0.59211949
147MP0002075_abnormal_coat/hair_pigmentati0.58463372
148MP0002938_white_spotting0.56353661
149MP0003699_abnormal_female_reproductive0.53960410
150MP0002970_abnormal_white_adipose0.52627826
151MP0005330_cardiomyopathy0.52306156
152MP0002638_abnormal_pupillary_reflex0.51405266
153MP0000749_muscle_degeneration0.49543392
154MP0001186_pigmentation_phenotype0.49522661
155MP0004084_abnormal_cardiac_muscle0.49257718
156MP0001984_abnormal_olfaction0.48063586
157MP0008995_early_reproductive_senescence0.47725421
158MP0001661_extended_life_span0.47211529
159MP0003950_abnormal_plasma_membrane0.46750737
160MP0006054_spinal_hemorrhage0.45551090

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.62541797
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.60647971
3Abnormality of chromosome stability (HP:0003220)4.60210056
4Abnormality of the preputium (HP:0100587)4.31599128
5Oral leukoplakia (HP:0002745)4.25688530
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.96663028
7Birth length less than 3rd percentile (HP:0003561)3.95629518
8Meckel diverticulum (HP:0002245)3.79494582
9Abnormality of midbrain morphology (HP:0002418)3.75526645
10Molar tooth sign on MRI (HP:0002419)3.75526645
11Abnormal number of erythroid precursors (HP:0012131)3.70643955
12Abnormality of the ileum (HP:0001549)3.63422828
13Pancreatic fibrosis (HP:0100732)3.62398478
14Aplastic anemia (HP:0001915)3.55385801
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.54373055
16Abnormal spermatogenesis (HP:0008669)3.53932896
17Bone marrow hypocellularity (HP:0005528)3.52748327
18Rough bone trabeculation (HP:0100670)3.51022566
19True hermaphroditism (HP:0010459)3.33968314
20Impulsivity (HP:0100710)3.31564634
21Abnormality of cells of the erythroid lineage (HP:0012130)3.26071338
22Cerebral hypomyelination (HP:0006808)3.24441170
23Myelodysplasia (HP:0002863)3.22392199
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.13439711
25Absent/shortened dynein arms (HP:0200106)3.13439711
26Reticulocytopenia (HP:0001896)3.12945881
27Acute necrotizing encephalopathy (HP:0006965)3.08225206
28Congenital stationary night blindness (HP:0007642)2.99492130
29Abnormality of DNA repair (HP:0003254)2.98267984
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.97212807
31Duodenal stenosis (HP:0100867)2.93896703
32Small intestinal stenosis (HP:0012848)2.93896703
33Abnormality of the renal cortex (HP:0011035)2.93561912
34Abnormality of the carotid arteries (HP:0005344)2.91979129
35Increased CSF lactate (HP:0002490)2.91048475
36Premature graying of hair (HP:0002216)2.90856448
37Mitochondrial inheritance (HP:0001427)2.90529371
38Abnormality of the renal medulla (HP:0100957)2.84847356
39Absent thumb (HP:0009777)2.84415597
40Medial flaring of the eyebrow (HP:0010747)2.82704051
41Ectopic kidney (HP:0000086)2.81604187
42Chronic hepatic failure (HP:0100626)2.80255059
43Acute encephalopathy (HP:0006846)2.79643815
44Progressive macrocephaly (HP:0004481)2.78086940
45Abnormal mitochondria in muscle tissue (HP:0008316)2.76532162
46Selective tooth agenesis (HP:0001592)2.71151035
47Breast hypoplasia (HP:0003187)2.66492183
48Sloping forehead (HP:0000340)2.64458508
49Type II lissencephaly (HP:0007260)2.62304737
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.56769049
51Azoospermia (HP:0000027)2.53838786
52Abnormal respiratory motile cilium morphology (HP:0005938)2.53024004
53Abnormal respiratory epithelium morphology (HP:0012253)2.53024004
54Tracheoesophageal fistula (HP:0002575)2.52713831
55Squamous cell carcinoma (HP:0002860)2.51090966
56Hepatocellular necrosis (HP:0001404)2.50529796
57Attenuation of retinal blood vessels (HP:0007843)2.48213476
58Hepatic necrosis (HP:0002605)2.44978368
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.44439381
60Pancytopenia (HP:0001876)2.44278501
61Abnormal trabecular bone morphology (HP:0100671)2.43393965
62Renal cortical cysts (HP:0000803)2.43369122
63Hyperventilation (HP:0002883)2.42232051
64Sclerocornea (HP:0000647)2.40157007
65Agnosia (HP:0010524)2.39057359
66Severe visual impairment (HP:0001141)2.38784606
673-Methylglutaconic aciduria (HP:0003535)2.37819108
68Duplicated collecting system (HP:0000081)2.37160716
69Clubbing of toes (HP:0100760)2.37089058
70Cellular immunodeficiency (HP:0005374)2.36539769
71High pitched voice (HP:0001620)2.35518582
72Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.34979450
73Absent epiphyses (HP:0010577)2.34979450
74Methylmalonic acidemia (HP:0002912)2.34567645
75Congenital primary aphakia (HP:0007707)2.32297597
76Personality changes (HP:0000751)2.31440162
77Tongue fasciculations (HP:0001308)2.30004153
78Gait imbalance (HP:0002141)2.29676249
79Triphalangeal thumb (HP:0001199)2.28229622
80Pendular nystagmus (HP:0012043)2.27692285
81Medulloblastoma (HP:0002885)2.26718623
82Abnormality of the duodenum (HP:0002246)2.26341968
83Inability to walk (HP:0002540)2.25549440
84Horseshoe kidney (HP:0000085)2.24221194
85Abnormal respiratory motile cilium physiology (HP:0012261)2.20430407
86Methylmalonic aciduria (HP:0012120)2.20326476
87Abnormal drinking behavior (HP:0030082)2.19148742
88Polydipsia (HP:0001959)2.19148742
89Nephrogenic diabetes insipidus (HP:0009806)2.18666029
90Volvulus (HP:0002580)2.18052214
91Hypoplasia of the pons (HP:0012110)2.17184920
92Optic disc pallor (HP:0000543)2.16629724
93Absent radius (HP:0003974)2.15627578
94Abolished electroretinogram (ERG) (HP:0000550)2.15278049
95Patellar aplasia (HP:0006443)2.14780342
96Abnormality of the labia minora (HP:0012880)2.14594590
97Progressive inability to walk (HP:0002505)2.14063068
98Nephronophthisis (HP:0000090)2.12479685
99Aplasia involving forearm bones (HP:0009822)2.10242839
100Absent forearm bone (HP:0003953)2.10242839
101Abnormal rod and cone electroretinograms (HP:0008323)2.09642268
102Abnormality of alanine metabolism (HP:0010916)2.09093112
103Hyperalaninemia (HP:0003348)2.09093112
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09093112
10511 pairs of ribs (HP:0000878)2.08468602
106Anencephaly (HP:0002323)2.08410690
107Short tibia (HP:0005736)2.08166731
108Pallor (HP:0000980)2.07675878
109Lipid accumulation in hepatocytes (HP:0006561)2.06457184
110Increased hepatocellular lipid droplets (HP:0006565)2.06425843
111Cerebral edema (HP:0002181)2.05540288
112Lymphoma (HP:0002665)2.05159582
113Muscle fibrillation (HP:0010546)2.04828260
114Cystic liver disease (HP:0006706)2.04202913
115CNS hypomyelination (HP:0003429)2.03936853
116Unsteady gait (HP:0002317)2.03876805
117Lissencephaly (HP:0001339)2.03509626
118Abnormality of the pons (HP:0007361)2.02614681
119Bony spicule pigmentary retinopathy (HP:0007737)2.00721271
120Neoplasm of the pancreas (HP:0002894)1.99329040
121Leukopenia (HP:0001882)1.98405511
122Lactic acidosis (HP:0003128)1.96656909
123Aplasia/Hypoplasia of the tongue (HP:0010295)1.96583956
124Type I transferrin isoform profile (HP:0003642)1.96477884
125Tubular atrophy (HP:0000092)1.95997730
126Microretrognathia (HP:0000308)1.95451807
127Thrombocytosis (HP:0001894)1.94572350
128Aplasia/Hypoplasia of the patella (HP:0006498)1.93413040
129Degeneration of anterior horn cells (HP:0002398)1.91136553
130Abnormality of the anterior horn cell (HP:0006802)1.91136553
131Genital tract atresia (HP:0001827)1.89606973
132Cafe-au-lait spot (HP:0000957)1.89206593
133Poor head control (HP:0002421)1.89045023
134Petechiae (HP:0000967)1.88418974
135Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88052384
136Colon cancer (HP:0003003)1.87977857
137Male pseudohermaphroditism (HP:0000037)1.87613367
138Short middle phalanx of the 5th finger (HP:0004220)1.87563625
139Abnormality of the renal collecting system (HP:0004742)1.86132143
140Renal Fanconi syndrome (HP:0001994)1.84600924
141Microvesicular hepatic steatosis (HP:0001414)1.84440076
142Vaginal atresia (HP:0000148)1.84139249
143Premature ovarian failure (HP:0008209)1.84091869
144Postaxial foot polydactyly (HP:0001830)1.83968680
145Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83353719
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83353719
147Abnormal biliary tract physiology (HP:0012439)1.83288273
148Bile duct proliferation (HP:0001408)1.83288273
149Congenital hepatic fibrosis (HP:0002612)1.81778855
150Cerebellar dysplasia (HP:0007033)1.81325604
151Ependymoma (HP:0002888)1.80412030
152Abnormality of abdominal situs (HP:0011620)1.79408322
153Abdominal situs inversus (HP:0003363)1.79408322
154Pancreatic cysts (HP:0001737)1.79223617
155Polyuria (HP:0000103)1.79122218
156Abnormality of pyrimidine metabolism (HP:0004353)1.78767116
157Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77757814
158Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77197060
159Prominent nose (HP:0000448)1.75910531
160Supernumerary spleens (HP:0009799)1.75826710
161Hypothermia (HP:0002045)1.75679234
162Increased serum lactate (HP:0002151)1.74710162
163Furrowed tongue (HP:0000221)1.74028368
164Retinal dysplasia (HP:0007973)1.73571637
165Decreased central vision (HP:0007663)1.73052959
166Abnormal ciliary motility (HP:0012262)1.72837217
167Oligodactyly (hands) (HP:0001180)1.71519457
168Preaxial hand polydactyly (HP:0001177)1.71260537
169Poor coordination (HP:0002370)1.71195833
170Dandy-Walker malformation (HP:0001305)1.69443777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.93746455
2WEE13.73277892
3BUB13.72015531
4NEK23.42702919
5EIF2AK13.38503269
6BMPR1B3.36513806
7STK163.16028429
8MAP4K22.84681932
9PDK42.84334869
10PDK32.84334869
11CDC72.71713530
12TTK2.57336258
13WNK32.30597584
14TESK12.21466107
15PIM22.19362968
16NUAK12.16463240
17DYRK32.14714261
18PLK42.14155193
19ATR2.12825965
20WNK42.12541436
21ADRBK22.06742989
22TSSK62.03602108
23SRPK11.97957561
24NME21.94487528
25ZAK1.87939284
26TRIM281.87780288
27PASK1.86747608
28BRSK21.86650103
29STK38L1.84965861
30CASK1.81918947
31CHEK21.80325818
32PLK11.75832328
33TAOK31.66876105
34EIF2AK31.61914716
35TLK11.60640815
36STK391.57197939
37MAPK131.51481626
38RPS6KA41.50770770
39TAOK21.49463371
40GRK11.46785703
41PDK21.45392204
42MAP3K41.38146342
43OXSR11.37545809
44CDK71.36646330
45MST41.36089160
46AURKB1.35930453
47VRK11.33109398
48CHEK11.33096513
49NEK11.32374833
50BRAF1.31906846
51MUSK1.22268532
52INSRR1.18239138
53VRK21.17656774
54FLT31.12275899
55BRSK11.10843632
56AURKA1.07502891
57CDK41.04879677
58CDK121.03609707
59TESK21.02369619
60ERBB31.01754962
61AKT31.01098599
62YES10.97558170
63NME10.97207038
64PLK30.95610075
65EIF2AK20.93611693
66LATS20.93574320
67RPS6KB20.92592230
68ICK0.92391457
69DYRK20.90373310
70BRD40.88093983
71CDK80.87439697
72PLK20.86890702
73ATM0.86170704
74CSNK1G20.84483355
75BCKDK0.83755382
76SCYL20.83392244
77PAK10.83075084
78MAP3K80.82053216
79MKNK20.81562087
80CSNK1G30.81343079
81MAPKAPK50.78811256
82PAK30.76473733
83CDK20.76090691
84CSNK1G10.75998399
85PIM10.75498333
86CCNB10.73955887
87BCR0.73419417
88MAP3K110.73135739
89ADRBK10.72565336
90ACVR1B0.72383738
91CSNK1A1L0.70999072
92STK100.69439231
93MKNK10.68933418
94EPHA20.68087675
95TXK0.67521866
96RAF10.67511030
97MAP3K120.65498841
98PRKCG0.65379675
99PBK0.64118586
100DAPK20.63929132
101STK240.63001977
102CSNK2A20.61173355
103TAF10.60365678
104MAP4K10.57273424
105STK30.56122769
106CSNK2A10.55958195
107CSF1R0.55533256
108MAP3K50.55409422
109CDK10.54784081
110TEC0.54162074
111PKN10.54122465
112PRKCQ0.53540165
113MAP2K30.50797900
114PRKCE0.50538259
115MAP2K70.49729911
116PNCK0.46969089
117PINK10.46558006
118MAPKAPK30.46096518
119STK40.45663759
120RPS6KB10.44555238
121TGFBR10.43824495
122MAP2K60.43454722
123PAK40.43421768
124IRAK40.42281267
125JAK30.40705294
126CSNK1A10.39354920
127FGFR20.38917657
128CDK90.38580752
129STK380.38306014
130ARAF0.38252026
131CSNK1E0.36983764
132MAPK150.36918201
133CAMK2A0.36221917
134MAP3K60.34554076
135MAPK110.34553722
136MARK10.33403667
137CDK30.32887361
138MINK10.32071920
139PRKCI0.31512654
140PRKACA0.31419619
141OBSCN0.31134417
142AKT20.30539735
143MTOR0.30499118
144KIT0.29873411
145PHKG10.28954577
146PHKG20.28954577
147KDR0.27272312
148RPS6KA50.25784081
149TYK20.25196162
150PRKDC0.25072307
151CDK190.24333530
152TNK20.23662034
153TNIK0.23661273
154ABL20.23539735

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94652889
2Mismatch repair_Homo sapiens_hsa034303.93857653
3Homologous recombination_Homo sapiens_hsa034403.77430910
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55122518
5Fanconi anemia pathway_Homo sapiens_hsa034603.23194737
6Base excision repair_Homo sapiens_hsa034103.21590661
7RNA polymerase_Homo sapiens_hsa030203.13644233
8* RNA transport_Homo sapiens_hsa030133.04329364
9Proteasome_Homo sapiens_hsa030502.92823630
10Nucleotide excision repair_Homo sapiens_hsa034202.87751609
11Oxidative phosphorylation_Homo sapiens_hsa001902.87639549
12Spliceosome_Homo sapiens_hsa030402.75801900
13Pyrimidine metabolism_Homo sapiens_hsa002402.75224012
14Non-homologous end-joining_Homo sapiens_hsa034502.55582146
15One carbon pool by folate_Homo sapiens_hsa006702.51117744
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40103771
17Cell cycle_Homo sapiens_hsa041102.38262592
18Parkinsons disease_Homo sapiens_hsa050122.37651528
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33693803
20Ribosome_Homo sapiens_hsa030102.30516203
21Basal transcription factors_Homo sapiens_hsa030222.15055273
22Butanoate metabolism_Homo sapiens_hsa006501.91718504
23RNA degradation_Homo sapiens_hsa030181.90833596
24Phototransduction_Homo sapiens_hsa047441.84557833
25Pentose phosphate pathway_Homo sapiens_hsa000301.73522746
26Nitrogen metabolism_Homo sapiens_hsa009101.72657374
27Purine metabolism_Homo sapiens_hsa002301.68083376
28p53 signaling pathway_Homo sapiens_hsa041151.58685059
29Vitamin B6 metabolism_Homo sapiens_hsa007501.56122480
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52379047
31Alzheimers disease_Homo sapiens_hsa050101.48474982
32mRNA surveillance pathway_Homo sapiens_hsa030151.41952639
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.32857145
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.31630923
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30141009
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28963419
37Nicotine addiction_Homo sapiens_hsa050331.25564129
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25192044
39Biosynthesis of amino acids_Homo sapiens_hsa012301.24256181
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24078710
41Taste transduction_Homo sapiens_hsa047421.16715865
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15731378
43Sulfur relay system_Homo sapiens_hsa041221.14349425
44Folate biosynthesis_Homo sapiens_hsa007901.12041166
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08086221
46Selenocompound metabolism_Homo sapiens_hsa004501.06506901
47Epstein-Barr virus infection_Homo sapiens_hsa051691.05146654
48Tryptophan metabolism_Homo sapiens_hsa003801.02168573
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00987074
50Peroxisome_Homo sapiens_hsa041460.99010929
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98344972
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96960397
53Olfactory transduction_Homo sapiens_hsa047400.94557603
54Cardiac muscle contraction_Homo sapiens_hsa042600.92952744
55Carbon metabolism_Homo sapiens_hsa012000.91692640
56Antigen processing and presentation_Homo sapiens_hsa046120.91549198
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90938647
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85792647
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84011540
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83776695
61Fructose and mannose metabolism_Homo sapiens_hsa000510.83656096
62Fatty acid elongation_Homo sapiens_hsa000620.81688605
63Herpes simplex infection_Homo sapiens_hsa051680.81651796
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.80416920
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79176673
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77348883
67Caffeine metabolism_Homo sapiens_hsa002320.77287087
68Chemical carcinogenesis_Homo sapiens_hsa052040.77166815
69Oocyte meiosis_Homo sapiens_hsa041140.76235925
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.74000439
71Systemic lupus erythematosus_Homo sapiens_hsa053220.73605688
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72791279
73Legionellosis_Homo sapiens_hsa051340.72300569
74Sulfur metabolism_Homo sapiens_hsa009200.71960602
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.70935403
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70026057
77Asthma_Homo sapiens_hsa053100.69510552
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69082167
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.65601764
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65402127
81Viral carcinogenesis_Homo sapiens_hsa052030.65083318
82Retinol metabolism_Homo sapiens_hsa008300.64455467
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.63919663
84Regulation of autophagy_Homo sapiens_hsa041400.63574719
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62856428
86Morphine addiction_Homo sapiens_hsa050320.61596191
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59220528
88Collecting duct acid secretion_Homo sapiens_hsa049660.56872907
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56664422
90Huntingtons disease_Homo sapiens_hsa050160.56136017
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54672206
92Steroid biosynthesis_Homo sapiens_hsa001000.54469227
93N-Glycan biosynthesis_Homo sapiens_hsa005100.50113657
94HTLV-I infection_Homo sapiens_hsa051660.48823724
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47028333
96Metabolic pathways_Homo sapiens_hsa011000.46652498
97Fatty acid metabolism_Homo sapiens_hsa012120.46291339
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45182686
99Protein export_Homo sapiens_hsa030600.44413258
100ABC transporters_Homo sapiens_hsa020100.41739066
101Linoleic acid metabolism_Homo sapiens_hsa005910.41375347
102Glutathione metabolism_Homo sapiens_hsa004800.40927134
103GABAergic synapse_Homo sapiens_hsa047270.40558785
104beta-Alanine metabolism_Homo sapiens_hsa004100.39383565
105Type I diabetes mellitus_Homo sapiens_hsa049400.38732305
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38398407
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37972072
108Vitamin digestion and absorption_Homo sapiens_hsa049770.36888908
109Serotonergic synapse_Homo sapiens_hsa047260.36221544
110Pyruvate metabolism_Homo sapiens_hsa006200.35227882
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34215209
112Other glycan degradation_Homo sapiens_hsa005110.33233843
113Apoptosis_Homo sapiens_hsa042100.32143983
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31378601
115Alcoholism_Homo sapiens_hsa050340.31235258
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30761254
117Propanoate metabolism_Homo sapiens_hsa006400.30165189
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.29621127
119Fatty acid biosynthesis_Homo sapiens_hsa000610.29499519
120Shigellosis_Homo sapiens_hsa051310.28931077
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28248895
122Lysine degradation_Homo sapiens_hsa003100.26674741
123Arginine and proline metabolism_Homo sapiens_hsa003300.26571292
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24708593
125Renin-angiotensin system_Homo sapiens_hsa046140.24479014
126Small cell lung cancer_Homo sapiens_hsa052220.23843535
127Hematopoietic cell lineage_Homo sapiens_hsa046400.22883493
128Measles_Homo sapiens_hsa051620.22505346
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21243552
130Arachidonic acid metabolism_Homo sapiens_hsa005900.19995285
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.18442454
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18053894
133Galactose metabolism_Homo sapiens_hsa000520.17415779
134Primary immunodeficiency_Homo sapiens_hsa053400.17411652
135HIF-1 signaling pathway_Homo sapiens_hsa040660.16596462
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16263739
137Influenza A_Homo sapiens_hsa051640.15819481
138MicroRNAs in cancer_Homo sapiens_hsa052060.13497157
139Glucagon signaling pathway_Homo sapiens_hsa049220.12447101
140Hepatitis B_Homo sapiens_hsa051610.12443964
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.10862768
142Acute myeloid leukemia_Homo sapiens_hsa052210.10381915
143Circadian rhythm_Homo sapiens_hsa047100.09323144
144Bladder cancer_Homo sapiens_hsa052190.09321343
145Fatty acid degradation_Homo sapiens_hsa000710.07589733
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06349550
147Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.06208066
148Ether lipid metabolism_Homo sapiens_hsa005650.05977100
149Thyroid cancer_Homo sapiens_hsa052160.04434301

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