NUS1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.25140337
2chaperone-mediated protein transport (GO:0072321)5.23602082
3pseudouridine synthesis (GO:0001522)4.94367074
4GDP-mannose metabolic process (GO:0019673)4.80287412
5ribosome biogenesis (GO:0042254)4.54481830
6chaperone mediated protein folding requiring cofactor (GO:0051085)4.48606711
7spliceosomal tri-snRNP complex assembly (GO:0000244)4.28971349
8protein-cofactor linkage (GO:0018065)4.22027647
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.09417578
10negative regulation of telomerase activity (GO:0051974)3.99909610
11ribonucleoprotein complex biogenesis (GO:0022613)3.92908198
12proteasome assembly (GO:0043248)3.89458256
13spliceosomal snRNP assembly (GO:0000387)3.86606154
14negative regulation of B cell apoptotic process (GO:0002903)3.84379629
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.80404170
16transcription from mitochondrial promoter (GO:0006390)3.79149929
17ribosomal small subunit biogenesis (GO:0042274)3.68405430
18peptidyl-arginine omega-N-methylation (GO:0035247)3.66856047
19innate immune response in mucosa (GO:0002227)3.64735103
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64372531
21DNA replication-dependent nucleosome assembly (GO:0006335)3.63526963
22DNA replication-dependent nucleosome organization (GO:0034723)3.63526963
23ATP synthesis coupled proton transport (GO:0015986)3.60538374
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60538374
25ribosomal small subunit assembly (GO:0000028)3.56048330
26tRNA modification (GO:0006400)3.55279017
27rRNA processing (GO:0006364)3.52230125
28protein targeting to mitochondrion (GO:0006626)3.49925103
29regulation of mitochondrial translation (GO:0070129)3.48418077
30establishment of protein localization to mitochondrion (GO:0072655)3.48278443
31viral mRNA export from host cell nucleus (GO:0046784)3.46775081
32termination of RNA polymerase III transcription (GO:0006386)3.46061365
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.46061365
34chromatin assembly (GO:0031497)3.45520806
35maturation of SSU-rRNA (GO:0030490)3.41671856
36rRNA metabolic process (GO:0016072)3.40845154
37inner mitochondrial membrane organization (GO:0007007)3.38735355
38cellular component biogenesis (GO:0044085)3.27601876
397-methylguanosine mRNA capping (GO:0006370)3.27574190
40protein K6-linked ubiquitination (GO:0085020)3.27082358
41protein deneddylation (GO:0000338)3.22816500
42proline biosynthetic process (GO:0006561)3.20702982
43RNA capping (GO:0036260)3.17360873
447-methylguanosine RNA capping (GO:0009452)3.17360873
45tRNA processing (GO:0008033)3.16943878
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15394739
47deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.15164100
48mitochondrial RNA metabolic process (GO:0000959)3.13618521
49negative regulation of telomere maintenance (GO:0032205)3.11260168
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.09292906
51mucosal immune response (GO:0002385)3.08616919
52pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.04925156
53transcription-coupled nucleotide-excision repair (GO:0006283)3.03671372
54tRNA methylation (GO:0030488)3.03228742
55ncRNA processing (GO:0034470)3.02677517
56protein localization to mitochondrion (GO:0070585)3.02401340
57DNA strand elongation involved in DNA replication (GO:0006271)3.00189157
58telomere maintenance via semi-conservative replication (GO:0032201)2.96963352
59water-soluble vitamin biosynthetic process (GO:0042364)2.96817091
60DNA strand elongation (GO:0022616)2.91748225
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89425236
62ribosomal large subunit biogenesis (GO:0042273)2.89390007
63protein maturation by protein folding (GO:0022417)2.87739568
64tRNA metabolic process (GO:0006399)2.86827601
65antibacterial humoral response (GO:0019731)2.85014595
66regulation of translational termination (GO:0006449)2.84690981
67pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84201076
68rRNA modification (GO:0000154)2.83491382
69ncRNA metabolic process (GO:0034660)2.82997340
70peptidyl-arginine methylation (GO:0018216)2.82749137
71peptidyl-arginine N-methylation (GO:0035246)2.82749137
72deoxyribose phosphate biosynthetic process (GO:0046385)2.82711711
732-deoxyribonucleotide biosynthetic process (GO:0009265)2.82711711
74pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.81637104
75respiratory electron transport chain (GO:0022904)2.79326211
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78527372
77positive regulation of viral transcription (GO:0050434)2.77608293
78translation (GO:0006412)2.77065615
79regulation of telomerase activity (GO:0051972)2.76574332
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76233628
81translational elongation (GO:0006414)2.74809686
82electron transport chain (GO:0022900)2.74463136
83purine deoxyribonucleotide catabolic process (GO:0009155)2.74043124
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73810862
85pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.73302677
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.72469210
87histone arginine methylation (GO:0034969)2.69158117
88protein localization to chromosome, centromeric region (GO:0071459)2.66458143
89nucleosome assembly (GO:0006334)2.65898137
90viral transcription (GO:0019083)2.64272824
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63631817
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.63272782
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63272782
94negative regulation of RNA splicing (GO:0033119)2.63206109
95metallo-sulfur cluster assembly (GO:0031163)2.63174207
96iron-sulfur cluster assembly (GO:0016226)2.63174207
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.62509304
98negative regulation of cell cycle arrest (GO:0071157)2.61673070
99de novo protein folding (GO:0006458)2.60680378
100de novo posttranslational protein folding (GO:0051084)2.60246611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.72156488
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31822888
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.23725595
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10756233
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99794924
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.89127030
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84733147
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83121161
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80564209
10E2F7_22180533_ChIP-Seq_HELA_Human2.73070387
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68843043
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68321830
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61571342
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59789190
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58938895
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54358050
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.44595784
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41963148
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38843626
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35068744
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.27608488
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24074496
23ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.20296356
24XRN2_22483619_ChIP-Seq_HELA_Human2.18578745
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.18329946
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.17483920
27MYC_22102868_ChIP-Seq_BL_Human2.14974048
28VDR_23849224_ChIP-Seq_CD4+_Human2.09216769
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.08127248
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07851284
31DCP1A_22483619_ChIP-Seq_HELA_Human2.05347153
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03225758
33CIITA_25753668_ChIP-Seq_RAJI_Human2.01292132
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94878352
35GABP_19822575_ChIP-Seq_HepG2_Human1.92790710
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89083438
37FOXP3_21729870_ChIP-Seq_TREG_Human1.87353981
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86848126
39ZNF263_19887448_ChIP-Seq_K562_Human1.84897138
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.84041658
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84000557
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83206483
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80168036
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77385688
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72863330
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.71881184
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69776735
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67180922
49TTF2_22483619_ChIP-Seq_HELA_Human1.66121663
50VDR_21846776_ChIP-Seq_THP-1_Human1.65844808
51MYC_18940864_ChIP-ChIP_HL60_Human1.64563529
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64086295
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63482547
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.62509987
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58322949
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.55881819
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50024020
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.48531668
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46473002
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.45158283
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43497389
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40888747
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39237450
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34668372
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33276256
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31696008
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30418323
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29219480
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.26424193
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26353793
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26152412
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21227343
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16890985
74KDM5A_27292631_Chip-Seq_BREAST_Human1.16044244
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14891608
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13546898
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10091096
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08767721
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08530852
80MAF_26560356_Chip-Seq_TH1_Human1.07956431
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07819415
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07333868
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.06952109
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06599981
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06132705
86FOXP1_21924763_ChIP-Seq_HESCs_Human1.05801196
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05531404
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05350477
89P68_20966046_ChIP-Seq_HELA_Human1.05121594
90ELK1_19687146_ChIP-ChIP_HELA_Human1.03694986
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03308069
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00246071
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99024250
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96765146
95LXR_22292898_ChIP-Seq_THP-1_Human0.95897989
96BCL6_27268052_Chip-Seq_Bcells_Human0.95851838
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.95527141
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95281280
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94736908
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94465432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.23665471
2MP0005645_abnormal_hypothalamus_physiol4.05195104
3MP0010094_abnormal_chromosome_stability3.66631488
4MP0004145_abnormal_muscle_electrophysio3.18886558
5MP0001529_abnormal_vocalization3.14485774
6MP0003693_abnormal_embryo_hatching3.13274094
7MP0008007_abnormal_cellular_replicative3.05887979
8MP0000685_abnormal_immune_system3.04573037
9MP0008058_abnormal_DNA_repair2.79419697
10MP0003077_abnormal_cell_cycle2.54344976
11MP0003786_premature_aging2.45956771
12MP0008877_abnormal_DNA_methylation2.35670551
13MP0003950_abnormal_plasma_membrane2.33456700
14MP0009046_muscle_twitch2.22912489
15MP0005623_abnormal_meninges_morphology2.13799180
16MP0004957_abnormal_blastocyst_morpholog2.12216770
17MP0006035_abnormal_mitochondrial_morpho1.91213738
18MP0008932_abnormal_embryonic_tissue1.79435509
19MP0001727_abnormal_embryo_implantation1.78303842
20MP0005671_abnormal_response_to1.75840693
21MP0000358_abnormal_cell_content/1.69299945
22MP0003763_abnormal_thymus_physiology1.66804850
23MP0002254_reproductive_system_inflammat1.63535051
24MP0000350_abnormal_cell_proliferation1.63200035
25MP0000678_abnormal_parathyroid_gland1.61039410
26MP0005257_abnormal_intraocular_pressure1.56154458
27MP0002332_abnormal_exercise_endurance1.55120494
28MP0003718_maternal_effect1.51045210
29MP0005360_urolithiasis1.46040832
30MP0000049_abnormal_middle_ear1.40154381
31MP0002138_abnormal_hepatobiliary_system1.38519378
32MP0001881_abnormal_mammary_gland1.38510179
33MP0002089_abnormal_postnatal_growth/wei1.36172373
34MP0002282_abnormal_trachea_morphology1.35976157
35MP0000703_abnormal_thymus_morphology1.34879088
36MP0002160_abnormal_reproductive_system1.32521186
37MP0009333_abnormal_splenocyte_physiolog1.29533851
38MP0002396_abnormal_hematopoietic_system1.28358721
39MP0006036_abnormal_mitochondrial_physio1.26150425
40MP0000313_abnormal_cell_death1.22066066
41MP0002019_abnormal_tumor_incidence1.21973646
42MP0000631_abnormal_neuroendocrine_gland1.20946548
43MP0001730_embryonic_growth_arrest1.15133960
44MP0009250_abnormal_appendicular_skeleto1.15005077
45MP0001873_stomach_inflammation1.14131147
46MP0003123_paternal_imprinting1.13308589
47MP0002398_abnormal_bone_marrow1.13038946
48MP0001661_extended_life_span1.12174001
49MP0001270_distended_abdomen1.11277251
50MP0005084_abnormal_gallbladder_morpholo1.10877925
51MP0004742_abnormal_vestibular_system1.10388519
52MP0002249_abnormal_larynx_morphology1.08692178
53MP0008057_abnormal_DNA_replication1.08213596
54MP0002166_altered_tumor_susceptibility1.07056983
55MP0001879_abnormal_lymphatic_vessel1.05561440
56MP0004510_myositis1.04884979
57MP0002722_abnormal_immune_system1.04265555
58MP0004134_abnormal_chest_morphology1.02375536
59MP0005266_abnormal_metabolism1.01136501
60MP0001293_anophthalmia0.98834759
61MP0002210_abnormal_sex_determination0.98675061
62MP0005389_reproductive_system_phenotype0.97853596
63MP0001800_abnormal_humoral_immune0.97287988
64MP0002080_prenatal_lethality0.92788521
65MP0000490_abnormal_crypts_of0.91893078
66MP0002429_abnormal_blood_cell0.88768777
67MP0001919_abnormal_reproductive_system0.87656116
68MP0001790_abnormal_immune_system0.84749463
69MP0005387_immune_system_phenotype0.84749463
70MP0000750_abnormal_muscle_regeneration0.84392883
71MP0003942_abnormal_urinary_system0.83973948
72MP0001697_abnormal_embryo_size0.83215930
73MP0000689_abnormal_spleen_morphology0.82837733
74MP0002006_tumorigenesis0.82762997
75MP0000716_abnormal_immune_system0.81543026
76MP0000733_abnormal_muscle_development0.79516514
77MP0010368_abnormal_lymphatic_system0.78647353
78MP0002177_abnormal_outer_ear0.77400611
79MP0003186_abnormal_redox_activity0.76936225
80MP0005499_abnormal_olfactory_system0.75408810
81MP0005394_taste/olfaction_phenotype0.75408810
82MP0010030_abnormal_orbit_morphology0.74111694
83MP0003984_embryonic_growth_retardation0.72297158
84MP0003315_abnormal_perineum_morphology0.71290783
85MP0008995_early_reproductive_senescence0.71196566
86MP0001905_abnormal_dopamine_level0.70412647
87MP0001348_abnormal_lacrimal_gland0.70233721
88MP0005000_abnormal_immune_tolerance0.70179310
89MP0000749_muscle_degeneration0.69527032
90MP0005384_cellular_phenotype0.69454467
91MP0001764_abnormal_homeostasis0.68016965
92MP0000026_abnormal_inner_ear0.67548336
93MP0002723_abnormal_immune_serum0.66494173
94MP0001672_abnormal_embryogenesis/_devel0.66082840
95MP0005380_embryogenesis_phenotype0.66082840
96MP0002088_abnormal_embryonic_growth/wei0.65562570
97MP0008789_abnormal_olfactory_epithelium0.65221935
98MP0002653_abnormal_ependyma_morphology0.64014843
99MP0000747_muscle_weakness0.61932695
100MP0002420_abnormal_adaptive_immunity0.61544067

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.51439096
2Abnormality of cells of the erythroid lineage (HP:0012130)3.89181894
3Abnormal mitochondria in muscle tissue (HP:0008316)3.81667890
4Acute encephalopathy (HP:0006846)3.62690094
5Acute necrotizing encephalopathy (HP:0006965)3.48562901
6Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.43793036
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.27685967
8Mitochondrial inheritance (HP:0001427)3.26223984
9IgA deficiency (HP:0002720)3.22985144
10Increased intramyocellular lipid droplets (HP:0012240)3.21256657
11Gastrointestinal stroma tumor (HP:0100723)3.07740580
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.02186112
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.02186112
14Muscle fiber atrophy (HP:0100295)3.01146632
15Testicular atrophy (HP:0000029)3.01042989
16Microvesicular hepatic steatosis (HP:0001414)3.00863653
17IgM deficiency (HP:0002850)2.97719257
18Increased serum lactate (HP:0002151)2.93090852
19Type 2 muscle fiber atrophy (HP:0003554)2.88792102
20Renal Fanconi syndrome (HP:0001994)2.88045905
21Increased muscle lipid content (HP:0009058)2.77107507
22Microretrognathia (HP:0000308)2.75058331
23Abnormality of the pons (HP:0007361)2.72376479
24Hypoplasia of the pons (HP:0012110)2.71649430
25Unilateral renal agenesis (HP:0000122)2.70762479
26Increased hepatocellular lipid droplets (HP:0006565)2.70383152
27Increased CSF lactate (HP:0002490)2.69041505
28Septate vagina (HP:0001153)2.65951578
29Cleft eyelid (HP:0000625)2.65466801
30Progressive muscle weakness (HP:0003323)2.62294367
31Hepatocellular necrosis (HP:0001404)2.59108910
32Recurrent sinusitis (HP:0011108)2.56892482
33Progressive macrocephaly (HP:0004481)2.53350068
343-Methylglutaconic aciduria (HP:0003535)2.52594458
35IgG deficiency (HP:0004315)2.52493150
36Hypoplasia of the uterus (HP:0000013)2.52097317
37Methylmalonic aciduria (HP:0012120)2.51366830
38Abnormal number of incisors (HP:0011064)2.49704492
39Cerebral edema (HP:0002181)2.49224100
40Lipid accumulation in hepatocytes (HP:0006561)2.46831488
41Aplasia/hypoplasia of the uterus (HP:0008684)2.45785004
42Concave nail (HP:0001598)2.44941772
43Hyperglycinemia (HP:0002154)2.40616032
44Conical tooth (HP:0000698)2.35628089
45Lactic acidosis (HP:0003128)2.35378771
46Squamous cell carcinoma (HP:0002860)2.32575727
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31992817
48Cholecystitis (HP:0001082)2.27527545
49Abnormal gallbladder physiology (HP:0012438)2.27527545
50Acute lymphatic leukemia (HP:0006721)2.26011517
51Exercise intolerance (HP:0003546)2.25452360
52Hepatic necrosis (HP:0002605)2.25261817
53Lymphopenia (HP:0001888)2.24110954
54Redundant skin (HP:0001582)2.21418216
55Trismus (HP:0000211)2.21146229
56Abnormality of T cell physiology (HP:0011840)2.20401652
57Reduced subcutaneous adipose tissue (HP:0003758)2.19799027
58Severe visual impairment (HP:0001141)2.17879176
59Sclerocornea (HP:0000647)2.16941235
60Methylmalonic acidemia (HP:0002912)2.16006764
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.12218516
62Progressive microcephaly (HP:0000253)2.08994965
63Rough bone trabeculation (HP:0100670)2.03793043
64Exertional dyspnea (HP:0002875)2.00293817
65Abnormality of subcutaneous fat tissue (HP:0001001)1.99571580
66Hypertensive crisis (HP:0100735)1.99571012
67Congenital stationary night blindness (HP:0007642)1.97331721
68Respiratory difficulties (HP:0002880)1.95674052
69Tongue fasciculations (HP:0001308)1.95489481
70Agammaglobulinemia (HP:0004432)1.93873057
71Entropion (HP:0000621)1.90077799
72Aplastic anemia (HP:0001915)1.88475711
73Dry hair (HP:0011359)1.87475702
74Absent thumb (HP:0009777)1.85609424
75Rectovaginal fistula (HP:0000143)1.85184070
76Rectal fistula (HP:0100590)1.85184070
77Multiple enchondromatosis (HP:0005701)1.84979648
78Fibular aplasia (HP:0002990)1.83583352
79Delayed CNS myelination (HP:0002188)1.81543304
80Poor head control (HP:0002421)1.81105751
81Vaginal fistula (HP:0004320)1.80871195
82Reduced antithrombin III activity (HP:0001976)1.80275401
83Abnormality of the anterior horn cell (HP:0006802)1.79340882
84Degeneration of anterior horn cells (HP:0002398)1.79340882
85B lymphocytopenia (HP:0010976)1.79162597
86Intestinal fistula (HP:0100819)1.77420311
87Cortical visual impairment (HP:0100704)1.77317733
88Onycholysis (HP:0001806)1.74994485
89Abnormality of glycolysis (HP:0004366)1.72932933
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72794981
91Dicarboxylic aciduria (HP:0003215)1.72794981
92Pendular nystagmus (HP:0012043)1.71204614
93Type I transferrin isoform profile (HP:0003642)1.69463596
94Reticulocytopenia (HP:0001896)1.68719992
95Horseshoe kidney (HP:0000085)1.67766412
96Decreased subcutaneous fat (HP:0001002)1.65807021
97Premature skin wrinkling (HP:0100678)1.65630782
98Fatigable weakness (HP:0003473)1.65101902
99Abnormality of the neuromuscular junction (HP:0003398)1.65101902
100Difficulty climbing stairs (HP:0003551)1.61821285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.69804319
2VRK14.53608912
3TLK14.34850813
4BCKDK4.25786834
5MAP4K24.02157816
6VRK23.57035008
7BUB12.55690176
8TESK22.48970611
9IRAK32.36428204
10RPS6KA52.24291685
11AURKA2.17521006
12SMG12.13543113
13DAPK31.95654348
14CHEK21.91013025
15ARAF1.85450033
16CDK121.82752065
17MAP3K91.75241813
18PIM21.66359231
19MAP4K11.60455411
20AURKB1.47508208
21CDK81.45041950
22CDC71.37334344
23IRAK41.36065570
24CDK91.30662813
25NME21.29339186
26KDR1.18776986
27MST1R1.11710042
28STK41.10951715
29SIK11.10511079
30NME11.08465974
31ICK1.08191262
32MAP3K111.04830944
33GRK61.02752642
34CSNK1G31.02633929
35TESK11.01983923
36NEK10.99373751
37TAF10.97905731
38CDK40.94104096
39MAPKAPK50.92754991
40WNK40.91382924
41BRSK10.91163198
42MAP3K80.90954782
43CDK70.90323604
44ATR0.88220115
45CSNK1A1L0.87150764
46MAP3K100.86433945
47TSSK60.80507899
48MAPK110.80468685
49MAPKAPK30.79694426
50CAMKK20.78161565
51MAP2K70.77061435
52DAPK10.75272651
53STK100.74366210
54EIF2AK10.73502370
55LMTK20.73264832
56CCNB10.72715589
57BRAF0.72406343
58CHEK10.70813531
59PKN10.69481314
60EEF2K0.65343965
61IKBKB0.63297804
62BTK0.61399531
63PLK10.58099664
64CHUK0.58079022
65CSNK1G10.57924542
66SCYL20.56794344
67EIF2AK20.54706310
68TTK0.54297645
69TAOK30.52956110
70CSNK1G20.50567036
71MAP3K130.47869961
72ABL20.47171404
73CSF1R0.45276973
74PIM10.42739141
75PRKCI0.41759284
76TBK10.41214722
77SRPK10.40641767
78EPHA20.40003373
79TRIB30.39414390
80PRKD20.39377794
81AKT20.37889248
82CSNK2A20.36726722
83CAMK1D0.36338237
84PLK40.36207674
85HIPK20.35646670
86ALK0.34756306
87RAF10.34652848
88EIF2AK30.34192360
89CDK20.33531400
90ATM0.33329871
91PAK10.33321072
92TAOK20.30478319
93TXK0.27976818
94CDK11A0.27605101
95MKNK20.27248351
96TIE10.27147775
97CDK150.26059081
98CSNK2A10.25721080
99BRSK20.24590363
100DYRK20.24537608

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.28511982
2Alcoholism_Homo sapiens_hsa050344.11936122
3RNA polymerase_Homo sapiens_hsa030203.36710874
4Ribosome_Homo sapiens_hsa030103.15030582
5Sulfur relay system_Homo sapiens_hsa041223.11450469
6DNA replication_Homo sapiens_hsa030302.87191734
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84209318
8Proteasome_Homo sapiens_hsa030502.81594141
9Pyrimidine metabolism_Homo sapiens_hsa002402.29105110
10Homologous recombination_Homo sapiens_hsa034402.22229906
11Primary immunodeficiency_Homo sapiens_hsa053402.20197629
12Oxidative phosphorylation_Homo sapiens_hsa001902.16858586
13Spliceosome_Homo sapiens_hsa030402.12951247
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.09106289
15Mismatch repair_Homo sapiens_hsa034302.05516953
16Parkinsons disease_Homo sapiens_hsa050121.96677086
17Base excision repair_Homo sapiens_hsa034101.89639938
18Viral carcinogenesis_Homo sapiens_hsa052031.82202147
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63534097
20Allograft rejection_Homo sapiens_hsa053301.60714548
21Huntingtons disease_Homo sapiens_hsa050161.54455498
22Vitamin B6 metabolism_Homo sapiens_hsa007501.51394738
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49519031
24Autoimmune thyroid disease_Homo sapiens_hsa053201.48246493
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42529956
26Nucleotide excision repair_Homo sapiens_hsa034201.41731114
27Asthma_Homo sapiens_hsa053101.39707779
28RNA transport_Homo sapiens_hsa030131.39015321
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36933565
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36778256
31Epstein-Barr virus infection_Homo sapiens_hsa051691.30875587
32Fructose and mannose metabolism_Homo sapiens_hsa000511.30091814
33Fanconi anemia pathway_Homo sapiens_hsa034601.26932385
34Viral myocarditis_Homo sapiens_hsa054161.26399284
35One carbon pool by folate_Homo sapiens_hsa006701.20471903
36Graft-versus-host disease_Homo sapiens_hsa053321.17677649
37Alzheimers disease_Homo sapiens_hsa050101.15524636
38Purine metabolism_Homo sapiens_hsa002301.14989506
39Selenocompound metabolism_Homo sapiens_hsa004501.14877798
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12315795
41Type I diabetes mellitus_Homo sapiens_hsa049401.08621033
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06375992
43Protein export_Homo sapiens_hsa030600.98041220
44Basal transcription factors_Homo sapiens_hsa030220.91163874
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90534233
46Biosynthesis of amino acids_Homo sapiens_hsa012300.87786476
47RNA degradation_Homo sapiens_hsa030180.86686346
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79124271
49Antigen processing and presentation_Homo sapiens_hsa046120.75884979
50Cell cycle_Homo sapiens_hsa041100.74631070
51Tyrosine metabolism_Homo sapiens_hsa003500.73273849
52Cardiac muscle contraction_Homo sapiens_hsa042600.72936944
53Herpes simplex infection_Homo sapiens_hsa051680.71042517
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.70127975
55p53 signaling pathway_Homo sapiens_hsa041150.67973861
56mRNA surveillance pathway_Homo sapiens_hsa030150.64426500
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59474474
58N-Glycan biosynthesis_Homo sapiens_hsa005100.54526619
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53727198
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.52185330
61HTLV-I infection_Homo sapiens_hsa051660.49595619
62Carbon metabolism_Homo sapiens_hsa012000.44780715
63Metabolic pathways_Homo sapiens_hsa011000.40577424
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40272381
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39779047
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38474246
67Renin-angiotensin system_Homo sapiens_hsa046140.38178969
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37814673
69Basal cell carcinoma_Homo sapiens_hsa052170.37733790
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37586957
71Phenylalanine metabolism_Homo sapiens_hsa003600.37232741
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36855872
73Folate biosynthesis_Homo sapiens_hsa007900.36598771
74Steroid biosynthesis_Homo sapiens_hsa001000.35791159
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34533535
76Influenza A_Homo sapiens_hsa051640.29278348
77Vibrio cholerae infection_Homo sapiens_hsa051100.28939814
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.27485385
79Non-homologous end-joining_Homo sapiens_hsa034500.27427491
80Fatty acid elongation_Homo sapiens_hsa000620.26836498
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25957930
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25546819
83Sulfur metabolism_Homo sapiens_hsa009200.25504976
84B cell receptor signaling pathway_Homo sapiens_hsa046620.24687131
85Apoptosis_Homo sapiens_hsa042100.23674934
86Leishmaniasis_Homo sapiens_hsa051400.23048617
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20947282
88Hedgehog signaling pathway_Homo sapiens_hsa043400.20546711
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20260701
90Pyruvate metabolism_Homo sapiens_hsa006200.19665756
91Hematopoietic cell lineage_Homo sapiens_hsa046400.19563988
92Pentose phosphate pathway_Homo sapiens_hsa000300.18117388
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17686972
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14338725
95Glutathione metabolism_Homo sapiens_hsa004800.13276357
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13013254
97Shigellosis_Homo sapiens_hsa051310.11174286
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11056954
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08988488
100Rheumatoid arthritis_Homo sapiens_hsa053230.08863343

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