ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	8.81066006
2	segment specification (GO:0007379)	7.50588783
3	cilium or flagellum-dependent cell motility (GO:0001539)	6.87866302
4	epithelial cilium movement (GO:0003351)	6.17426317
5	axonemal dynein complex assembly (GO:0070286)	6.07981736
6	cilium movement (GO:0003341)	5.81155967
7	proximal/distal pattern formation (GO:0009954)	4.76256637
8	axoneme assembly (GO:0035082)	4.56917505
9	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	4.48897522
10	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	4.48897522
11	cytoplasmic mRNA processing body assembly (GO:0033962)	4.13627862
12	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.13350176
13	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	4.05675425
14	epithelial cell maturation (GO:0002070)	4.01686065
15	motile cilium assembly (GO:0044458)	3.89097135
16	intraciliary transport (GO:0042073)	3.82236462
17	metanephros development (GO:0001656)	3.78881630
18	olfactory bulb development (GO:0021772)	3.77492804
19	DNA double-strand break processing (GO:0000729)	3.69416391
20	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.57879798
21	behavioral response to nicotine (GO:0035095)	3.52890652
22	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.45313758
23	mesonephros development (GO:0001823)	3.38371177
24	insulin-like growth factor receptor signaling pathway (GO:0048009)	3.36518454
25	left/right axis specification (GO:0070986)	3.35281088
26	regulation of cilium movement (GO:0003352)	3.32666839
27	otic vesicle formation (GO:0030916)	3.30310322
28	glucocorticoid biosynthetic process (GO:0006704)	3.29415865
29	lens fiber cell development (GO:0070307)	3.18091710
30	ovulation from ovarian follicle (GO:0001542)	3.18065569
31	lung-associated mesenchyme development (GO:0060484)	3.06302555
32	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	3.03477686
33	cilium organization (GO:0044782)	3.02686978
34	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.01270705
35	multicellular organismal movement (GO:0050879)	3.00045599
36	musculoskeletal movement (GO:0050881)	3.00045599
37	nonmotile primary cilium assembly (GO:0035058)	2.98684049
38	maternal behavior (GO:0042711)	2.93858795
39	response to morphine (GO:0043278)	2.92718896
40	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.90354368
41	cilium assembly (GO:0042384)	2.89131877
42	response to isoquinoline alkaloid (GO:0014072)	2.86897109
43	heart valve formation (GO:0003188)	2.84387228
44	protein targeting to Golgi (GO:0000042)	2.84126535
45	multicellular organism reproduction (GO:0032504)	2.82695048
46	startle response (GO:0001964)	2.81796179
47	nephron tubule formation (GO:0072079)	2.80742484
48	establishment of protein localization to Golgi (GO:0072600)	2.79921752
49	mRNA splice site selection (GO:0006376)	2.76203601
50	prostate gland growth (GO:0060736)	2.75059116
51	binding of sperm to zona pellucida (GO:0007339)	2.74737244
52	positive regulation of action potential (GO:0045760)	2.72786431
53	microtubule bundle formation (GO:0001578)	2.71527763
54	positive regulation of vascular permeability (GO:0043117)	2.71360713
55	paraxial mesoderm development (GO:0048339)	2.70841143
56	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.67248070
57	RNA localization (GO:0006403)	2.66162429
58	metanephric tubule development (GO:0072170)	2.65401713
59	metanephric nephron tubule development (GO:0072234)	2.65401713
60	establishment of mitochondrion localization (GO:0051654)	2.63365934
61	cilium morphogenesis (GO:0060271)	2.61195760
62	ventricular system development (GO:0021591)	2.59502527
63	retinal cone cell development (GO:0046549)	2.59400066
64	regulation of glucocorticoid secretion (GO:2000849)	2.59315265
65	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.58389160
66	parental behavior (GO:0060746)	2.56798383
67	positive regulation of mitochondrial fission (GO:0090141)	2.54502000
68	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.51158585
69	spinal cord motor neuron differentiation (GO:0021522)	2.50532198
70	mating behavior (GO:0007617)	2.48991618
71	axon extension involved in axon guidance (GO:0048846)	2.48869979
72	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.48869979
73	somite development (GO:0061053)	2.48048477
74	embryonic camera-type eye development (GO:0031076)	2.47849880
75	limb development (GO:0060173)	2.47392284
76	appendage development (GO:0048736)	2.47392284
77	retinal rod cell development (GO:0046548)	2.43898928
78	protein localization to Golgi apparatus (GO:0034067)	2.43404209
79	DNA topological change (GO:0006265)	2.43149246
80	cell differentiation involved in metanephros development (GO:0072202)	2.43074849
81	seminiferous tubule development (GO:0072520)	2.42103448
82	cranial nerve morphogenesis (GO:0021602)	2.39525218
83	lateral sprouting from an epithelium (GO:0060601)	2.38705265
84	behavioral response to ethanol (GO:0048149)	2.38479004
85	cellular component assembly involved in morphogenesis (GO:0010927)	2.36824285
86	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.35738167
87	microtubule-based movement (GO:0007018)	2.35032288
88	regulation of stem cell maintenance (GO:2000036)	2.34784507
89	ganglion development (GO:0061548)	2.33881003
90	establishment of tissue polarity (GO:0007164)	2.32761550
91	establishment of planar polarity (GO:0001736)	2.32761550
92	pyrimidine nucleobase catabolic process (GO:0006208)	2.32366049
93	hindlimb morphogenesis (GO:0035137)	2.30454905
94	nephron tubule development (GO:0072080)	2.29565240
95	negative regulation of mRNA processing (GO:0050686)	2.29355403
96	cell differentiation in spinal cord (GO:0021515)	2.28875822
97	histone H3-K9 methylation (GO:0051567)	2.28390585
98	collecting duct development (GO:0072044)	2.27822529
99	branched-chain amino acid catabolic process (GO:0009083)	2.27544594
100	pattern specification involved in kidney development (GO:0061004)	14.0781000

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.72796889
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.65285434
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.44663704
4	ESR1_15608294_ChIP-ChIP_MCF-7_Human	3.11760557
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08368719
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89669101
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.50823944
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.37705680
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.33014224
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.31082436
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10815295
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.04327581
13	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.03808119
14	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.01735468
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.01604747
16	CBP_20019798_ChIP-Seq_JUKART_Human	2.01604747
17	RNF2_27304074_Chip-Seq_NSC_Mouse	1.99795648
18	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.97666356
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.95520390
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.90411184
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89801337
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.87584513
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.81867856
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.80830779
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80500649
26	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.78996328
27	EWS_26573619_Chip-Seq_HEK293_Human	1.74539804
28	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.67808599
29	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.62855950
30	FUS_26573619_Chip-Seq_HEK293_Human	1.60502814
31	VDR_22108803_ChIP-Seq_LS180_Human	1.60095346
32	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.55600709
33	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.55600709
34	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.55600709
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55323658
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.54838157
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.52053002
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.49416786
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48040689
40	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47461026
41	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.42772832
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.42686561
43	EZH2_22144423_ChIP-Seq_EOC_Human	1.40598469
44	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.38917522
45	P300_19829295_ChIP-Seq_ESCs_Human	1.38632126
46	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.38384090
47	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.33700752
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.31620083
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31308008
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.29199194
51	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27983906
52	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.27183764
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.26801070
54	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.26667999
55	KDM5A_27292631_Chip-Seq_BREAST_Human	1.23726768
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23534074
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.23152392
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23058515
59	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22754330
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20187094
61	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17446084
62	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.12948706
63	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.12680338
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11361980
65	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.09929967
66	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07226848
67	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07226848
68	CIITA_25753668_ChIP-Seq_RAJI_Human	1.06607436
69	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.06507944
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05095452
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04096109
72	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.04012456
73	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.01838663
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.01712354
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.99941740
76	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.99916064
77	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99282594
78	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.98448984
79	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96164923
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96019594
81	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.95312176
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94767706
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94767706
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.94108775
85	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93966400
86	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.92418349
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.92379794
88	AR_21572438_ChIP-Seq_LNCaP_Human	0.92204277
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92148295
90	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.92093616
91	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.91812108
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91805836
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91660313
94	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.91009520
95	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88471135
96	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88263347
97	SMAD4_21799915_ChIP-Seq_A2780_Human	0.88204535
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.87449703
99	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.87139719
100	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.86122230

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002254_reproductive_system_inflammat	6.08226352
2	MP0003787_abnormal_imprinting	3.13555744
3	MP0002653_abnormal_ependyma_morphology	2.87044640
4	MP0004133_heterotaxia	2.51394804
5	MP0002009_preneoplasia	2.40992731
6	MP0003938_abnormal_ear_development	2.23393663
7	MP0010386_abnormal_urinary_bladder	2.20954853
8	MP0005248_abnormal_Harderian_gland	2.19920600
9	MP0000049_abnormal_middle_ear	2.15371184
10	MP0003136_yellow_coat_color	2.12970026
11	MP0001984_abnormal_olfaction	2.09001585
12	MP0003385_abnormal_body_wall	2.06707287
13	MP0000778_abnormal_nervous_system	2.01439968
14	MP0003941_abnormal_skin_development	1.86558167
15	MP0003890_abnormal_embryonic-extraembry	1.81604820
16	MP0006292_abnormal_olfactory_placode	1.75046679
17	MP0005499_abnormal_olfactory_system	1.74193379
18	MP0005394_taste/olfaction_phenotype	1.74193379
19	MP0000534_abnormal_ureter_morphology	1.68579809
20	MP0003937_abnormal_limbs/digits/tail_de	1.65593929
21	MP0002160_abnormal_reproductive_system	1.63083614
22	MP0003942_abnormal_urinary_system	1.61816805
23	MP0001529_abnormal_vocalization	1.59038078
24	MP0001919_abnormal_reproductive_system	1.47493015
25	MP0006072_abnormal_retinal_apoptosis	1.44882737
26	MP0009780_abnormal_chondrocyte_physiolo	1.40464747
27	MP0001286_abnormal_eye_development	1.40201944
28	MP0000631_abnormal_neuroendocrine_gland	1.39986255
29	MP0008789_abnormal_olfactory_epithelium	1.39612139
30	MP0002102_abnormal_ear_morphology	1.38057541
31	MP0000383_abnormal_hair_follicle	1.35849095
32	MP0003121_genomic_imprinting	1.35580543
33	MP0005253_abnormal_eye_physiology	1.35312313
34	MP0005389_reproductive_system_phenotype	1.35228241
35	MP0004859_abnormal_synaptic_plasticity	1.33257178
36	MP0001502_abnormal_circadian_rhythm	1.32817112
37	MP0002249_abnormal_larynx_morphology	1.31173668
38	MP0002233_abnormal_nose_morphology	1.29396069
39	MP0002697_abnormal_eye_size	1.28509014
40	MP0002084_abnormal_developmental_patter	1.27056652
41	MP0010094_abnormal_chromosome_stability	1.26938871
42	MP0008877_abnormal_DNA_methylation	1.26001376
43	MP0002282_abnormal_trachea_morphology	1.25986547
44	MP0003880_abnormal_central_pattern	1.24028922
45	MP0001293_anophthalmia	1.21077042
46	MP0006276_abnormal_autonomic_nervous	1.20555151
47	MP0005391_vision/eye_phenotype	1.18738555
48	MP0003693_abnormal_embryo_hatching	1.18501498
49	MP0002638_abnormal_pupillary_reflex	1.17722763
50	MP0001299_abnormal_eye_distance/	1.17571304
51	MP0000026_abnormal_inner_ear	1.16642573
52	MP0003861_abnormal_nervous_system	1.14595690
53	MP0008932_abnormal_embryonic_tissue	1.14486112
54	MP0005646_abnormal_pituitary_gland	1.13483124
55	MP0000516_abnormal_urinary_system	1.12762339
56	MP0005367_renal/urinary_system_phenotyp	1.12762339
57	MP0009046_muscle_twitch	1.10711296
58	MP0002557_abnormal_social/conspecific_i	1.07931266
59	MP0008058_abnormal_DNA_repair	1.07738864
60	MP0000537_abnormal_urethra_morphology	1.07355879
61	MP0002092_abnormal_eye_morphology	1.07085662
62	MP0004957_abnormal_blastocyst_morpholog	1.06929702
63	MP0005187_abnormal_penis_morphology	1.06138351
64	MP0003755_abnormal_palate_morphology	1.04155896
65	MP0003077_abnormal_cell_cycle	1.01875071
66	MP0002152_abnormal_brain_morphology	1.00914230
67	MP0001486_abnormal_startle_reflex	1.00587853
68	MP0002752_abnormal_somatic_nervous	1.00141159
69	MP0003315_abnormal_perineum_morphology	1.00026474
70	MP0002085_abnormal_embryonic_tissue	0.99287911
71	MP0009053_abnormal_anal_canal	0.98267184
72	MP0002184_abnormal_innervation	0.97933244
73	MP0003879_abnormal_hair_cell	0.96209137
74	MP0009250_abnormal_appendicular_skeleto	0.95969534
75	MP0001188_hyperpigmentation	0.95894259
76	MP0008007_abnormal_cellular_replicative	0.92756553
77	MP0000566_synostosis	0.92330509
78	MP0000955_abnormal_spinal_cord	0.88661321
79	MP0002127_abnormal_cardiovascular_syste	0.87839791
80	MP0010307_abnormal_tumor_latency	0.87464449
81	MP0002081_perinatal_lethality	0.85294137
82	MP0003115_abnormal_respiratory_system	0.85293268
83	MP0002063_abnormal_learning/memory/cond	0.83286044
84	MP0009703_decreased_birth_body	0.82828669
85	MP0003935_abnormal_craniofacial_develop	0.82101346
86	MP0010030_abnormal_orbit_morphology	0.81213908
87	MP0002882_abnormal_neuron_morphology	0.80402053
88	MP0004197_abnormal_fetal_growth/weight/	0.80335219
89	MP0005551_abnormal_eye_electrophysiolog	0.77651860
90	MP0003567_abnormal_fetal_cardiomyocyte	0.77647864
91	MP0000733_abnormal_muscle_development	0.77539731
92	MP0005076_abnormal_cell_differentiation	0.76163868
93	MP0002876_abnormal_thyroid_physiology	0.75642107
94	MP0001485_abnormal_pinna_reflex	0.75199699
95	MP0005171_absent_coat_pigmentation	0.74926386
96	MP0002116_abnormal_craniofacial_bone	0.74699761
97	MP0002751_abnormal_autonomic_nervous	0.74324741
98	MP0003936_abnormal_reproductive_system	0.74189063
99	MP0005195_abnormal_posterior_eye	0.73720095
100	MP0001340_abnormal_eyelid_morphology	0.72618119

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.23301302
2	Abnormal respiratory motile cilium morphology (HP:0005938)	4.91662022
3	Abnormal respiratory epithelium morphology (HP:0012253)	4.91662022
4	Absent/shortened dynein arms (HP:0200106)	4.49984513
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.49984513
6	Abnormal ciliary motility (HP:0012262)	4.49670491
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.42854459
8	Split foot (HP:0001839)	3.70609079
9	Chronic bronchitis (HP:0004469)	3.46315401
10	Rhinitis (HP:0012384)	3.45847351
11	Genital tract atresia (HP:0001827)	3.03243583
12	Vaginal atresia (HP:0000148)	2.98355050
13	Nephronophthisis (HP:0000090)	2.92835639
14	Renal hypoplasia (HP:0000089)	2.80702416
15	Medial flaring of the eyebrow (HP:0010747)	2.76748507
16	Abnormality of midbrain morphology (HP:0002418)	2.71326682
17	Molar tooth sign on MRI (HP:0002419)	2.71326682
18	Congenital primary aphakia (HP:0007707)	2.70452761
19	Occipital encephalocele (HP:0002085)	2.69897980
20	Gait imbalance (HP:0002141)	2.69235480
21	True hermaphroditism (HP:0010459)	2.63540728
22	Pancreatic fibrosis (HP:0100732)	2.59349884
23	Pancreatic cysts (HP:0001737)	2.55582069
24	Renal dysplasia (HP:0000110)	2.53483054
25	Resting tremor (HP:0002322)	2.50382275
26	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.48908693
27	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.48817266
28	Tubulointerstitial nephritis (HP:0001970)	2.48723700
29	Bronchiectasis (HP:0002110)	2.47604659
30	Nephrogenic diabetes insipidus (HP:0009806)	2.46215074
31	Renal salt wasting (HP:0000127)	2.44153459
32	Facial cleft (HP:0002006)	2.41695774
33	Abnormality of the renal medulla (HP:0100957)	2.38321021
34	Stenosis of the external auditory canal (HP:0000402)	2.36762084
35	Bicornuate uterus (HP:0000813)	2.34420864
36	Chronic hepatic failure (HP:0100626)	2.32536584
37	Postaxial foot polydactyly (HP:0001830)	2.29881215
38	Postaxial hand polydactyly (HP:0001162)	2.28581243
39	Cutaneous finger syndactyly (HP:0010554)	2.27310947
40	Absent frontal sinuses (HP:0002688)	2.21537461
41	Poor coordination (HP:0002370)	2.13149896
42	Optic nerve coloboma (HP:0000588)	2.10747719
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09740718
44	Volvulus (HP:0002580)	2.08498518
45	Preaxial hand polydactyly (HP:0001177)	2.07896141
46	Infertility (HP:0000789)	2.03786913
47	Anophthalmia (HP:0000528)	1.99978161
48	Shawl scrotum (HP:0000049)	1.97988281
49	Cystic liver disease (HP:0006706)	1.96785542
50	Midline defect of the nose (HP:0004122)	1.95514213
51	Cutaneous syndactyly (HP:0012725)	1.95138365
52	Broad distal phalanx of finger (HP:0009836)	1.92826264
53	Abnormality of the frontal sinuses (HP:0002687)	1.92623425
54	Median cleft lip (HP:0000161)	1.91842588
55	Hemivertebrae (HP:0002937)	1.88916827
56	Intestinal atresia (HP:0011100)	1.88519248
57	Cortical dysplasia (HP:0002539)	1.87098310
58	Colon cancer (HP:0003003)	1.86991957
59	Drooling (HP:0002307)	1.84551579
60	High anterior hairline (HP:0009890)	1.83375628
61	Chorioretinal coloboma (HP:0000567)	1.81900795
62	Anal stenosis (HP:0002025)	1.81881948
63	Oligodactyly (hands) (HP:0001180)	1.81115055
64	Tubular atrophy (HP:0000092)	1.79807584
65	Decreased testicular size (HP:0008734)	1.79080884
66	Medulloblastoma (HP:0002885)	1.77447186
67	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.76779332
68	Abnormality of macular pigmentation (HP:0008002)	1.75791157
69	Abnormality of abdominal situs (HP:0011620)	1.73567705
70	Abdominal situs inversus (HP:0003363)	1.73567705
71	Rib fusion (HP:0000902)	1.72789824
72	Trigonocephaly (HP:0000243)	1.72669658
73	Multicystic kidney dysplasia (HP:0000003)	1.72655763
74	Male pseudohermaphroditism (HP:0000037)	1.69721552
75	Long nose (HP:0003189)	1.68766021
76	Bifid tongue (HP:0010297)	1.66424550
77	Horseshoe kidney (HP:0000085)	1.65630961
78	Broad foot (HP:0001769)	1.65378839
79	Scrotal hypoplasia (HP:0000046)	1.64682203
80	Anterior segment dysgenesis (HP:0007700)	1.64646534
81	Aplasia involving bones of the extremities (HP:0009825)	1.63300369
82	Aplasia involving bones of the upper limbs (HP:0009823)	1.63300369
83	Aplasia of the phalanges of the hand (HP:0009802)	1.63300369
84	Myelomeningocele (HP:0002475)	1.60918395
85	Ectopic anus (HP:0004397)	1.59754904
86	Bronchitis (HP:0012387)	1.59633852
87	Excessive salivation (HP:0003781)	1.59626346
88	Atelectasis (HP:0100750)	1.59171579
89	Abnormality of the incisor (HP:0000676)	1.58713616
90	Chorioretinal atrophy (HP:0000533)	1.57813639
91	Micropenis (HP:0000054)	1.57741495
92	Down-sloping shoulders (HP:0200021)	1.57301904
93	Gastrointestinal atresia (HP:0002589)	1.56419388
94	Short tibia (HP:0005736)	1.56185003
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.56002672
96	Bell-shaped thorax (HP:0001591)	1.55672027
97	Recurrent sinusitis (HP:0011108)	1.55560558
98	Fibular aplasia (HP:0002990)	1.55102840
99	Abnormality of the labia minora (HP:0012880)	1.54240241
100	Severe Myopia (HP:0011003)	1.52983798

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.37331581
2	PIM2	4.32219351
3	MAPK15	3.88773941
4	BCR	3.50741742
5	DYRK1B	3.35569421
6	MAP4K2	2.78901751
7	EIF2AK3	2.57216847
8	MAP2K7	2.22181862
9	CDK8	2.18084957
10	TGFBR1	2.12663260
11	SRPK1	1.89442771
12	BCKDK	1.86119098
13	MAP3K4	1.80089933
14	CDK3	1.71453200
15	CDK6	1.69662512
16	STK16	1.58792758
17	ERBB3	1.55855985
18	CASK	1.50335875
19	PAK6	1.50164919
20	LATS1	1.48363391
21	SIK3	1.46213018
22	TRIM28	1.45643615
23	CSNK1A1L	1.40925446
24	PDK2	1.37249176
25	DYRK3	1.31550900
26	CSNK1G2	1.30323988
27	STK38L	1.29367818
28	CSNK1G3	1.25923436
29	FGFR2	1.24795866
30	NUAK1	1.23347006
31	TAOK3	1.19197125
32	RPS6KA4	1.15921843
33	CDK9	1.15263851
34	SIK2	1.14492162
35	PIK3CA	1.12243299
36	EPHA3	1.10027651
37	LATS2	1.09467404
38	DYRK2	1.06231045
39	VRK1	1.04699636
40	CSNK1G1	0.99927879
41	CDK14	0.97511630
42	NTRK2	0.93714321
43	MARK1	0.92239313
44	MAPKAPK3	0.91577712
45	MKNK1	0.90877343
46	DAPK3	0.89496061
47	WNK3	0.88167115
48	CDK7	0.82583578
49	MAP3K5	0.80662790
50	CAMK2B	0.79045866
51	CDK11A	0.77768485
52	MKNK2	0.76356318
53	CDK18	0.75863994
54	TAF1	0.75830709
55	PINK1	0.75378364
56	MAPK13	0.74452134
57	CDK15	0.73579106
58	MUSK	0.70472873
59	PLK1	0.69399228
60	ZAK	0.67292900
61	EPHB2	0.65819922
62	UHMK1	0.63130175
63	TTK	0.62891367
64	PAK3	0.62854448
65	PRKD3	0.60738147
66	MOS	0.60585423
67	PLK2	0.58903069
68	TNIK	0.58850485
69	ATM	0.57673370
70	ATR	0.57597271
71	CAMK2G	0.56926654
72	CDK19	0.56501896
73	CAMK2D	0.52603624
74	PAK2	0.52049070
75	PLK3	0.50839641
76	CSNK1E	0.49598204
77	CDK2	0.49389610
78	FRK	0.49375285
79	AURKB	0.48111971
80	SIK1	0.47687653
81	MTOR	0.46237572
82	EIF2AK2	0.46124197
83	CHUK	0.46107432
84	PRKAA1	0.45466614
85	PRKDC	0.45193075
86	PLK4	0.45083072
87	CDK1	0.44992997
88	DYRK1A	0.44879147
89	RPS6KB1	0.44135933
90	MAPK14	0.43916808
91	CHEK1	0.43243016
92	AURKA	0.42866466
93	CDK5	0.42553878
94	GRK1	0.41894201
95	AKT2	0.40983366
96	PAK1	0.40946132
97	CSNK2A1	0.40737156
98	NTRK3	0.39948087
99	CAMK2A	0.39273665
100	PRKACB	0.38305965

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	3.58712771
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.25844608
3	Basal transcription factors_Homo sapiens_hsa03022	2.67382245
4	Spliceosome_Homo sapiens_hsa03040	2.63636779
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32960241
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.19171077
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.10868076
8	mRNA surveillance pathway_Homo sapiens_hsa03015	2.00447382
9	Nicotine addiction_Homo sapiens_hsa05033	1.99040822
10	RNA degradation_Homo sapiens_hsa03018	1.88112916
11	RNA transport_Homo sapiens_hsa03013	1.86935719
12	Circadian rhythm_Homo sapiens_hsa04710	1.83131964
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.82811233
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.77675686
15	Hippo signaling pathway_Homo sapiens_hsa04390	1.58741770
16	Butanoate metabolism_Homo sapiens_hsa00650	1.58718726
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.54174693
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.48960365
19	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.46034346
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.45807485
21	Propanoate metabolism_Homo sapiens_hsa00640	1.40984009
22	Base excision repair_Homo sapiens_hsa03410	1.37057210
23	Protein export_Homo sapiens_hsa03060	1.36807378
24	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.34781977
25	Melanoma_Homo sapiens_hsa05218	1.34385974
26	Cell cycle_Homo sapiens_hsa04110	1.28897973
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.28314537
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27259797
29	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.25810804
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.23374800
31	Basal cell carcinoma_Homo sapiens_hsa05217	1.22495607
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21520122
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.20319427
34	Fatty acid elongation_Homo sapiens_hsa00062	1.20144016
35	Wnt signaling pathway_Homo sapiens_hsa04310	1.12131389
36	p53 signaling pathway_Homo sapiens_hsa04115	1.09286490
37	Notch signaling pathway_Homo sapiens_hsa04330	1.09229331
38	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.08913528
39	Oocyte meiosis_Homo sapiens_hsa04114	1.07896497
40	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.07210712
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06716347
42	Lysine degradation_Homo sapiens_hsa00310	1.05618070
43	Mismatch repair_Homo sapiens_hsa03430	1.01233893
44	Huntingtons disease_Homo sapiens_hsa05016	0.99312388
45	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.98399399
46	Tight junction_Homo sapiens_hsa04530	0.95820286
47	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.93847838
48	AMPK signaling pathway_Homo sapiens_hsa04152	0.93466100
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.92315073
50	Regulation of autophagy_Homo sapiens_hsa04140	0.91260601
51	Cocaine addiction_Homo sapiens_hsa05030	0.90762473
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89799299
53	Phototransduction_Homo sapiens_hsa04744	0.89689368
54	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.89637423
55	Olfactory transduction_Homo sapiens_hsa04740	0.88329876
56	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.86311374
57	Taste transduction_Homo sapiens_hsa04742	0.82993618
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81906872
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80898182
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78867012
61	Axon guidance_Homo sapiens_hsa04360	0.77588833
62	Carbon metabolism_Homo sapiens_hsa01200	0.76947374
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74893649
64	Prostate cancer_Homo sapiens_hsa05215	0.69523177
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.68877824
66	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.68593404
67	Alcoholism_Homo sapiens_hsa05034	0.64965976
68	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.64407005
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.64365878
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.63299024
71	DNA replication_Homo sapiens_hsa03030	0.58819270
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58436587
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57582322
74	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56919273
75	ErbB signaling pathway_Homo sapiens_hsa04012	0.56841636
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.56612815
77	GABAergic synapse_Homo sapiens_hsa04727	0.55674258
78	Adherens junction_Homo sapiens_hsa04520	0.55189423
79	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53250967
80	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.52532924
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.52440396
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51854789
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.50511094
84	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.47659905
85	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.44294954
86	Galactose metabolism_Homo sapiens_hsa00052	0.43792444
87	Homologous recombination_Homo sapiens_hsa03440	0.43766769
88	Ras signaling pathway_Homo sapiens_hsa04014	0.40831308
89	Circadian entrainment_Homo sapiens_hsa04713	0.40692224
90	Bladder cancer_Homo sapiens_hsa05219	0.39534410
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.37862660
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.37723547
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37023158
94	MicroRNAs in cancer_Homo sapiens_hsa05206	0.36670214
95	Linoleic acid metabolism_Homo sapiens_hsa00591	0.35717058
96	Estrogen signaling pathway_Homo sapiens_hsa04915	0.35629629
97	Folate biosynthesis_Homo sapiens_hsa00790	0.35462268
98	Cholinergic synapse_Homo sapiens_hsa04725	0.34825636
99	Metabolic pathways_Homo sapiens_hsa01100	0.34301256
100	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34061165

NUS1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »