NUTF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.27045880
2viral transcription (GO:0019083)6.00958520
3translational termination (GO:0006415)5.81050434
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.29400818
5cotranslational protein targeting to membrane (GO:0006613)5.23866902
6ATP synthesis coupled proton transport (GO:0015986)5.22583343
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22583343
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.19335988
9protein targeting to ER (GO:0045047)5.15105774
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.91218280
11protein localization to endoplasmic reticulum (GO:0070972)4.87674962
12protein neddylation (GO:0045116)4.84169701
13translational elongation (GO:0006414)4.82815058
14ribosomal large subunit biogenesis (GO:0042273)4.78179815
15cellular protein complex disassembly (GO:0043624)4.72457085
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.62388844
17viral life cycle (GO:0019058)4.61654081
18axon ensheathment in central nervous system (GO:0032291)4.47879334
19central nervous system myelination (GO:0022010)4.47879334
20ribosomal small subunit assembly (GO:0000028)4.44049767
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.43077131
22termination of RNA polymerase III transcription (GO:0006386)4.42413516
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.42413516
24maturation of SSU-rRNA (GO:0030490)4.41724945
25translational initiation (GO:0006413)4.38304101
26proteasome assembly (GO:0043248)4.12137162
27cullin deneddylation (GO:0010388)4.10662607
28protein complex disassembly (GO:0043241)4.05268261
29respiratory electron transport chain (GO:0022904)3.99663346
30establishment of integrated proviral latency (GO:0075713)3.98669135
31translation (GO:0006412)3.98260416
32chaperone-mediated protein transport (GO:0072321)3.94720484
33electron transport chain (GO:0022900)3.89069649
34macromolecular complex disassembly (GO:0032984)3.87184826
35GTP biosynthetic process (GO:0006183)3.85085538
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.83168004
37NADH dehydrogenase complex assembly (GO:0010257)3.83168004
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83168004
39spliceosomal snRNP assembly (GO:0000387)3.70586212
40purine nucleobase biosynthetic process (GO:0009113)3.68901481
41protein complex biogenesis (GO:0070271)3.65457355
42spliceosomal complex assembly (GO:0000245)3.64997652
43ribonucleoprotein complex biogenesis (GO:0022613)3.63389138
44protein deneddylation (GO:0000338)3.60959262
45nucleobase biosynthetic process (GO:0046112)3.50978376
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.50444941
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.48891249
48DNA damage response, detection of DNA damage (GO:0042769)3.48630619
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47892341
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.47892341
51signal transduction involved in cell cycle checkpoint (GO:0072395)3.45289272
52rRNA modification (GO:0000154)3.44594896
53DNA ligation (GO:0006266)3.43007439
54protein targeting to membrane (GO:0006612)3.42523115
557-methylguanosine mRNA capping (GO:0006370)3.42294291
56RNA capping (GO:0036260)3.40169734
577-methylguanosine RNA capping (GO:0009452)3.40169734
58cellular component biogenesis (GO:0044085)3.39237728
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39236026
60mitochondrial respiratory chain complex assembly (GO:0033108)3.37574880
61UTP biosynthetic process (GO:0006228)3.36612774
62establishment of viral latency (GO:0019043)3.36562750
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33684788
64DNA double-strand break processing (GO:0000729)3.32875420
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32398668
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31551927
67DNA replication checkpoint (GO:0000076)3.31097279
68positive regulation of ligase activity (GO:0051351)3.30859222
69nuclear-transcribed mRNA catabolic process (GO:0000956)3.30084145
70histone exchange (GO:0043486)3.29680111
71mitotic metaphase plate congression (GO:0007080)3.28735078
72regulation of ubiquitin-protein transferase activity (GO:0051438)3.23568391
73telomere maintenance via recombination (GO:0000722)3.22533917
74rRNA processing (GO:0006364)3.21881127
75pseudouridine synthesis (GO:0001522)3.20385737
76kinetochore assembly (GO:0051382)3.19497750
77respiratory chain complex IV assembly (GO:0008535)3.18102587
78L-serine metabolic process (GO:0006563)3.15805565
79mitotic recombination (GO:0006312)3.15758656
80DNA catabolic process, exonucleolytic (GO:0000738)3.14546219
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14049836
82negative regulation of ligase activity (GO:0051352)3.14049836
83protein targeting to mitochondrion (GO:0006626)3.14008426
84IMP biosynthetic process (GO:0006188)3.10487121
85mRNA catabolic process (GO:0006402)3.10290189
86regulation of ligase activity (GO:0051340)3.09416053
87CENP-A containing nucleosome assembly (GO:0034080)3.06947769
88establishment of protein localization to mitochondrion (GO:0072655)3.06791882
89rRNA metabolic process (GO:0016072)3.06135396
90kinetochore organization (GO:0051383)3.03704590
91replication fork processing (GO:0031297)3.03269845
92chromatin remodeling at centromere (GO:0031055)3.01639458
93DNA replication-independent nucleosome organization (GO:0034724)3.01087237
94DNA replication-independent nucleosome assembly (GO:0006336)3.01087237
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00081017
96telomere maintenance via semi-conservative replication (GO:0032201)2.99636375
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.97488898
98ribosome assembly (GO:0042255)2.97062010
99transcription-coupled nucleotide-excision repair (GO:0006283)2.95528947
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95493680
101cytochrome complex assembly (GO:0017004)2.95028925
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94184169
103metaphase plate congression (GO:0051310)2.93889970
104oxidative phosphorylation (GO:0006119)2.93025667
105protein localization to kinetochore (GO:0034501)2.92984255
106DNA strand elongation involved in DNA replication (GO:0006271)2.91884847
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91659144
108guanosine-containing compound biosynthetic process (GO:1901070)2.91301010
109mitotic sister chromatid segregation (GO:0000070)2.91226294
110inner mitochondrial membrane organization (GO:0007007)2.90868937
111nuclear envelope reassembly (GO:0031468)2.88148622
112mitotic nuclear envelope reassembly (GO:0007084)2.88148622
113G1/S transition of mitotic cell cycle (GO:0000082)2.87034247
114cell cycle G1/S phase transition (GO:0044843)2.87034247
115transcription elongation from RNA polymerase I promoter (GO:0006362)2.87009105
116regulation of mitochondrial translation (GO:0070129)2.86965594
117viral mRNA export from host cell nucleus (GO:0046784)2.84930006
118DNA deamination (GO:0045006)2.84320939
119DNA replication-dependent nucleosome assembly (GO:0006335)2.84134208
120DNA replication-dependent nucleosome organization (GO:0034723)2.84134208
121telomere maintenance via telomere lengthening (GO:0010833)2.83997504
122RNA catabolic process (GO:0006401)2.83411927
123base-excision repair (GO:0006284)2.83193872
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81458640
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81326664
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81326664
127pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.81150361
128spindle checkpoint (GO:0031577)2.81039521
129UTP metabolic process (GO:0046051)2.79617361
130pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79496777
131peptidyl-histidine modification (GO:0018202)2.78774656
132DNA strand elongation (GO:0022616)2.77414912
133protein localization to mitochondrion (GO:0070585)2.77377819
134DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77230781
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74634719
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74634719
137regulation of cellular amino acid metabolic process (GO:0006521)2.74618936
138transcription from RNA polymerase I promoter (GO:0006360)2.72845131
139signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71348127
140signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71348127
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71348127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.26541850
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.66086334
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.07417258
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.96328963
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.84528417
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.48499911
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48461164
8E2F7_22180533_ChIP-Seq_HELA_Human3.42338795
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.38911247
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31834298
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.31658808
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.25288608
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07715046
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00533600
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.95096840
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88197637
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80589720
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69116063
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58715726
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52263626
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45823176
22* XRN2_22483619_ChIP-Seq_HELA_Human2.35559895
23DCP1A_22483619_ChIP-Seq_HELA_Human2.27787166
24* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21401518
25VDR_23849224_ChIP-Seq_CD4+_Human2.20308432
26* TTF2_22483619_ChIP-Seq_HELA_Human2.19883345
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19121419
28ELK1_19687146_ChIP-ChIP_HELA_Human2.06028978
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04689056
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92179884
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90646192
32FOXP3_21729870_ChIP-Seq_TREG_Human1.85135490
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80768263
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80345706
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.79333349
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77987122
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74490426
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.70800728
39* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.65076137
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61870956
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58135250
42GABP_19822575_ChIP-Seq_HepG2_Human1.55770148
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53441496
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50422456
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49639343
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.49411760
47MYC_18940864_ChIP-ChIP_HL60_Human1.49176344
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45574137
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43848954
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43032704
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39335280
52IRF1_19129219_ChIP-ChIP_H3396_Human1.38743265
53ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34283702
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33242781
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30053102
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.28121893
57FUS_26573619_Chip-Seq_HEK293_Human1.24185381
58VDR_22108803_ChIP-Seq_LS180_Human1.23780026
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23073297
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23073297
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23073297
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22869634
63* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22763901
64* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19849655
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.19378908
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14615989
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08886846
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.06912631
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.06896541
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06165604
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04809536
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04024248
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03930506
74CBX2_27304074_Chip-Seq_ESCs_Mouse0.99782523
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98477263
76AR_21909140_ChIP-Seq_LNCAP_Human0.97128675
77TAF15_26573619_Chip-Seq_HEK293_Human0.96053225
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95297090
79ZNF274_21170338_ChIP-Seq_K562_Hela0.92510013
80EWS_26573619_Chip-Seq_HEK293_Human0.91950014
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89209371
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86831740
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85385965
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85234897
85* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85076553
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84584342
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84187877
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.83735164
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82051762
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81730507
91E2F1_21310950_ChIP-Seq_MCF-7_Human0.81398104
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80897670
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80749115
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80614054
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80322200
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.78572851
97RNF2_27304074_Chip-Seq_NSC_Mouse0.78076513
98KDM5A_27292631_Chip-Seq_BREAST_Human0.77807302
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75876612
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75179897
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75126795
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73875866
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73841844
104CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73258679
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72055549
106* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.71327411
107* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71120932
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70847998
109* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.69999481
110* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69824549
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69773320
112EOMES_21245162_ChIP-Seq_HESCs_Human0.68278396
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.68027291
114* FOXP1_21924763_ChIP-Seq_HESCs_Human0.67182264
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66572111
116* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66023189
117FLI1_27457419_Chip-Seq_LIVER_Mouse0.65204464
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.64752036
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.64562860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.34498890
2MP0003136_yellow_coat_color3.36802542
3MP0003880_abnormal_central_pattern3.03977155
4MP0001529_abnormal_vocalization2.88036466
5MP0008932_abnormal_embryonic_tissue2.53828836
6MP0009697_abnormal_copulation2.45604677
7MP0001188_hyperpigmentation2.38723916
8MP0003186_abnormal_redox_activity2.24114082
9MP0004957_abnormal_blastocyst_morpholog2.21952650
10MP0001905_abnormal_dopamine_level2.20954818
11MP0003693_abnormal_embryo_hatching2.19475584
12MP0006292_abnormal_olfactory_placode2.17632984
13MP0003806_abnormal_nucleotide_metabolis2.15030443
14MP0008057_abnormal_DNA_replication2.10433486
15MP0010030_abnormal_orbit_morphology2.04580841
16MP0002938_white_spotting2.00826734
17MP0005409_darkened_coat_color1.94663143
18MP0002102_abnormal_ear_morphology1.84515288
19MP0006276_abnormal_autonomic_nervous1.78605338
20MP0010094_abnormal_chromosome_stability1.76109178
21MP0000778_abnormal_nervous_system1.74632514
22MP0004142_abnormal_muscle_tone1.71669440
23MP0002751_abnormal_autonomic_nervous1.69886784
24MP0000566_synostosis1.68294180
25MP0005423_abnormal_somatic_nervous1.68294158
26MP0000049_abnormal_middle_ear1.67481811
27MP0001986_abnormal_taste_sensitivity1.66459672
28MP0006035_abnormal_mitochondrial_morpho1.66199395
29MP0003077_abnormal_cell_cycle1.61954815
30MP0008789_abnormal_olfactory_epithelium1.61899979
31MP0004133_heterotaxia1.61162480
32MP0008058_abnormal_DNA_repair1.57888729
33MP0003938_abnormal_ear_development1.57120760
34MP0005171_absent_coat_pigmentation1.52289348
35MP0002234_abnormal_pharynx_morphology1.51619411
36MP0003315_abnormal_perineum_morphology1.43162003
37MP0000372_irregular_coat_pigmentation1.42035240
38MP0003111_abnormal_nucleus_morphology1.38335849
39MP0002163_abnormal_gland_morphology1.37824153
40MP0001485_abnormal_pinna_reflex1.37508675
41MP0000358_abnormal_cell_content/1.33027320
42MP0001697_abnormal_embryo_size1.32276712
43MP0002638_abnormal_pupillary_reflex1.32249720
44MP0006072_abnormal_retinal_apoptosis1.31655922
45MP0001730_embryonic_growth_arrest1.31177965
46MP0003786_premature_aging1.30074894
47MP0003718_maternal_effect1.28332655
48MP0002085_abnormal_embryonic_tissue1.27574810
49MP0005084_abnormal_gallbladder_morpholo1.27280809
50MP0004742_abnormal_vestibular_system1.26730689
51MP0009250_abnormal_appendicular_skeleto1.26129325
52MP0002734_abnormal_mechanical_nocicepti1.23478018
53MP0000920_abnormal_myelination1.22517329
54MP0005394_taste/olfaction_phenotype1.21589008
55MP0005499_abnormal_olfactory_system1.21589008
56MP0000350_abnormal_cell_proliferation1.21200671
57MP0000631_abnormal_neuroendocrine_gland1.19359808
58MP0004381_abnormal_hair_follicle1.19204670
59MP0003567_abnormal_fetal_cardiomyocyte1.18693494
60MP0003937_abnormal_limbs/digits/tail_de1.18222978
61MP0000762_abnormal_tongue_morphology1.16577211
62MP0005367_renal/urinary_system_phenotyp1.16145516
63MP0000516_abnormal_urinary_system1.16145516
64MP0004270_analgesia1.13848043
65MP0004147_increased_porphyrin_level1.13507576
66MP0003122_maternal_imprinting1.13203918
67MP0005408_hypopigmentation1.12648960
68MP0004145_abnormal_muscle_electrophysio1.08898445
69MP0002084_abnormal_developmental_patter1.08868930
70MP0002080_prenatal_lethality1.08525425
71MP0001672_abnormal_embryogenesis/_devel1.07641711
72MP0005380_embryogenesis_phenotype1.07641711
73MP0002697_abnormal_eye_size1.05813723
74MP0008007_abnormal_cellular_replicative1.04345269
75MP0002752_abnormal_somatic_nervous1.03960394
76MP0000026_abnormal_inner_ear1.03801215
77MP0003950_abnormal_plasma_membrane1.03146324
78MP0002272_abnormal_nervous_system1.01317211
79MP0001968_abnormal_touch/_nociception1.00669835
80MP0001346_abnormal_lacrimal_gland0.99976027
81MP0003123_paternal_imprinting0.98677777
82MP0002249_abnormal_larynx_morphology0.98238504
83MP0002132_abnormal_respiratory_system0.97532616
84MP0008877_abnormal_DNA_methylation0.96954843
85MP0001764_abnormal_homeostasis0.96276800
86MP0002111_abnormal_tail_morphology0.95798990
87MP0001929_abnormal_gametogenesis0.95212979
88MP0001970_abnormal_pain_threshold0.94588291
89MP0006054_spinal_hemorrhage0.94382390
90MP0005379_endocrine/exocrine_gland_phen0.94199310
91MP0002184_abnormal_innervation0.94134753
92MP0001727_abnormal_embryo_implantation0.94055242
93MP0003942_abnormal_urinary_system0.93311034
94MP0003121_genomic_imprinting0.93027052
95MP0000749_muscle_degeneration0.91935902
96MP0003755_abnormal_palate_morphology0.91668105
97MP0003385_abnormal_body_wall0.91420701
98MP0001286_abnormal_eye_development0.91246824
99MP0000313_abnormal_cell_death0.91059480
100MP0003861_abnormal_nervous_system0.91015148
101MP0003890_abnormal_embryonic-extraembry0.90674581
102MP0002277_abnormal_respiratory_mucosa0.90559024
103MP0002653_abnormal_ependyma_morphology0.89159508
104MP0000647_abnormal_sebaceous_gland0.88655990
105MP0001486_abnormal_startle_reflex0.88457738
106MP0002160_abnormal_reproductive_system0.88402656
107MP0008872_abnormal_physiological_respon0.87418702
108MP0000653_abnormal_sex_gland0.87150334
109MP0002177_abnormal_outer_ear0.86284682
110MP0003984_embryonic_growth_retardation0.86140089
111MP0002736_abnormal_nociception_after0.85990221
112MP0001293_anophthalmia0.85360433
113MP0000537_abnormal_urethra_morphology0.84533226
114MP0002882_abnormal_neuron_morphology0.84244039
115MP0002088_abnormal_embryonic_growth/wei0.83518033
116MP0001145_abnormal_male_reproductive0.83350949
117MP0009672_abnormal_birth_weight0.82854015
118MP0005253_abnormal_eye_physiology0.82644559
119MP0003941_abnormal_skin_development0.82100956
120MP0002210_abnormal_sex_determination0.81809809
121MP0005075_abnormal_melanosome_morpholog0.80932888
122MP0000462_abnormal_digestive_system0.80300645
123MP0002572_abnormal_emotion/affect_behav0.79838169
124MP0006036_abnormal_mitochondrial_physio0.79630774
125MP0002064_seizures0.79119446
126MP0001963_abnormal_hearing_physiology0.78782363
127MP0009053_abnormal_anal_canal0.76719381
128MP0002735_abnormal_chemical_nociception0.76650912
129MP0003137_abnormal_impulse_conducting0.76386784
130MP0004134_abnormal_chest_morphology0.75376346
131MP0002282_abnormal_trachea_morphology0.75302260
132MP0000955_abnormal_spinal_cord0.74902376
133MP0003119_abnormal_digestive_system0.74411034
134MP0005551_abnormal_eye_electrophysiolog0.73893762
135MP0001440_abnormal_grooming_behavior0.73488535
136MP0002067_abnormal_sensory_capabilities0.72649264
137MP0002233_abnormal_nose_morphology0.72246011
138MP0005395_other_phenotype0.71728871
139MP0001984_abnormal_olfaction0.71639880
140MP0005501_abnormal_skin_physiology0.71521994
141MP0003011_delayed_dark_adaptation0.71078764
142MP0001119_abnormal_female_reproductive0.70253051
143MP0005391_vision/eye_phenotype0.68839726
144MP0008995_early_reproductive_senescence0.66950778
145MP0002090_abnormal_vision0.63115499

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.07132233
2Mitochondrial inheritance (HP:0001427)4.60571852
3Abnormal mitochondria in muscle tissue (HP:0008316)4.40323946
4Increased hepatocellular lipid droplets (HP:0006565)4.28180431
5Progressive macrocephaly (HP:0004481)4.14849640
6Reticulocytopenia (HP:0001896)4.02389626
7Hepatocellular necrosis (HP:0001404)3.96553764
8Acute encephalopathy (HP:0006846)3.84485141
9Increased CSF lactate (HP:0002490)3.81021895
10Abnormality of glycolysis (HP:0004366)3.77878730
11Increased serum pyruvate (HP:0003542)3.77878730
12Abnormality of cells of the erythroid lineage (HP:0012130)3.71935741
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.69419402
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.67865658
15Macrocytic anemia (HP:0001972)3.66312778
16Renal Fanconi syndrome (HP:0001994)3.63672165
173-Methylglutaconic aciduria (HP:0003535)3.58547444
18Lipid accumulation in hepatocytes (HP:0006561)3.52415075
19Cerebral hypomyelination (HP:0006808)3.38004647
20Abnormal number of erythroid precursors (HP:0012131)3.20290575
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.19381881
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19094025
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19094025
24Parakeratosis (HP:0001036)3.13506799
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.07765790
26Hepatic necrosis (HP:0002605)3.03647784
27Exertional dyspnea (HP:0002875)3.00382306
28Pallor (HP:0000980)2.99204555
29Leukodystrophy (HP:0002415)2.94835425
30Optic disc pallor (HP:0000543)2.93167748
31Type I transferrin isoform profile (HP:0003642)2.91076438
32Colon cancer (HP:0003003)2.87346495
33Meckel diverticulum (HP:0002245)2.86814801
34Exercise intolerance (HP:0003546)2.86174785
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85479491
36Respiratory failure (HP:0002878)2.80459984
37Increased intramyocellular lipid droplets (HP:0012240)2.77728679
38Abnormality of the ileum (HP:0001549)2.71950499
39Increased serum lactate (HP:0002151)2.66770859
40Chromsome breakage (HP:0040012)2.66378331
41Concave nail (HP:0001598)2.60824388
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.59017313
43Abnormal hemoglobin (HP:0011902)2.46255310
44Sensory axonal neuropathy (HP:0003390)2.43918878
45Abnormality of the preputium (HP:0100587)2.40554817
46Hyperglycinemia (HP:0002154)2.39417136
47Breast hypoplasia (HP:0003187)2.37164541
48Abnormal protein glycosylation (HP:0012346)2.33789444
49Abnormal glycosylation (HP:0012345)2.33789444
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33789444
51Abnormal protein N-linked glycosylation (HP:0012347)2.33789444
52Triphalangeal thumb (HP:0001199)2.28595161
53Methylmalonic acidemia (HP:0002912)2.27125106
54Respiratory difficulties (HP:0002880)2.23413667
55Cerebral edema (HP:0002181)2.23293592
56Supernumerary spleens (HP:0009799)2.22963202
57Abnormality of methionine metabolism (HP:0010901)2.22631628
58Abnormality of the labia minora (HP:0012880)2.21163381
59Amniotic constriction ring (HP:0009775)2.20804374
60Abnormality of placental membranes (HP:0011409)2.20804374
61Microvesicular hepatic steatosis (HP:0001414)2.19242405
62Adrenal hypoplasia (HP:0000835)2.19198073
63Degeneration of anterior horn cells (HP:0002398)2.16965476
64Abnormality of the anterior horn cell (HP:0006802)2.16965476
65Progressive external ophthalmoplegia (HP:0000590)2.15279702
66Lactic acidosis (HP:0003128)2.14991047
67Multiple enchondromatosis (HP:0005701)2.14223545
68Abnormality of renal resorption (HP:0011038)2.12299568
69Congenital ichthyosiform erythroderma (HP:0007431)2.12018861
70Abnormality of chromosome stability (HP:0003220)2.11521072
71Reduced antithrombin III activity (HP:0001976)2.10334044
72Absent radius (HP:0003974)2.07118572
73Birth length less than 3rd percentile (HP:0003561)2.06323672
74Methylmalonic aciduria (HP:0012120)2.05938972
75Abnormality of the septum pellucidum (HP:0007375)2.05906365
76Duodenal stenosis (HP:0100867)2.03600259
77Small intestinal stenosis (HP:0012848)2.03600259
78Bifid tongue (HP:0010297)2.02270636
79Pancytopenia (HP:0001876)2.01066989
80Lethargy (HP:0001254)2.00130025
81Abnormality of serum amino acid levels (HP:0003112)1.99554686
82Horseshoe kidney (HP:0000085)1.97276840
83Increased muscle lipid content (HP:0009058)1.96994976
84Stenosis of the external auditory canal (HP:0000402)1.96864553
85Septo-optic dysplasia (HP:0100842)1.96648172
86Aplasia involving forearm bones (HP:0009822)1.96329286
87Absent forearm bone (HP:0003953)1.96329286
88Congenital, generalized hypertrichosis (HP:0004540)1.92172421
89Abnormal lung lobation (HP:0002101)1.90790562
90Absent septum pellucidum (HP:0001331)1.90397032
91Ependymoma (HP:0002888)1.90013198
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87946076
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87601264
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.87601264
95Limb dystonia (HP:0002451)1.86688391
96Aplasia/hypoplasia of the uterus (HP:0008684)1.86400241
97Absent thumb (HP:0009777)1.86179543
98Patellar aplasia (HP:0006443)1.85917297
99Abnormality of the duodenum (HP:0002246)1.85408844
100Duplicated collecting system (HP:0000081)1.85380096
101Partial duplication of the phalanx of hand (HP:0009999)1.85160280
102Medial flaring of the eyebrow (HP:0010747)1.83342776
103Aplasia/Hypoplasia of the patella (HP:0006498)1.82213192
104Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81377640
105Preaxial hand polydactyly (HP:0001177)1.80856323
106Partial duplication of thumb phalanx (HP:0009944)1.80176048
107Abnormality of alanine metabolism (HP:0010916)1.78873799
108Hyperalaninemia (HP:0003348)1.78873799
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78873799
110Hypothermia (HP:0002045)1.77665674
111Emotional lability (HP:0000712)1.77011073
112Hypoplastic pelvis (HP:0008839)1.76567397
113Duplication of thumb phalanx (HP:0009942)1.76312167
114Aplastic anemia (HP:0001915)1.75371992
115Neoplasm of the adrenal gland (HP:0100631)1.74495971
116Pancreatic fibrosis (HP:0100732)1.73185277
117Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73053962
118X-linked dominant inheritance (HP:0001423)1.69708127
119Anencephaly (HP:0002323)1.69703113
120Depressed nasal ridge (HP:0000457)1.69556263
121Nasolacrimal duct obstruction (HP:0000579)1.68481056
122CNS hypomyelination (HP:0003429)1.68259563
123Pancreatic islet-cell hyperplasia (HP:0004510)1.67689615
124Generalized aminoaciduria (HP:0002909)1.67658432
125Pancreatic cysts (HP:0001737)1.67386146
126Asplenia (HP:0001746)1.66870406
127Rough bone trabeculation (HP:0100670)1.66865713
128Postnatal microcephaly (HP:0005484)1.66795528
129Abnormal number of incisors (HP:0011064)1.66222781
130Microglossia (HP:0000171)1.66126353
131Abnormality of secondary sexual hair (HP:0009888)1.65748182
132Abnormality of the axillary hair (HP:0100134)1.65748182
133Abnormality of the renal collecting system (HP:0004742)1.64640684
134Gait imbalance (HP:0002141)1.64580442
135Ectopic kidney (HP:0000086)1.64300174
136Carpal bone hypoplasia (HP:0001498)1.63528764
137Type 2 muscle fiber atrophy (HP:0003554)1.62950849
138Sclerocornea (HP:0000647)1.62547616
139Sparse eyelashes (HP:0000653)1.61676750
140Oral leukoplakia (HP:0002745)1.60930158
141CNS demyelination (HP:0007305)1.60605357
142Hypoplasia of the radius (HP:0002984)1.60207079
143Hyperphosphaturia (HP:0003109)1.59419252
144Congenital primary aphakia (HP:0007707)1.58714372
145Myokymia (HP:0002411)1.57529166
146Retinal dysplasia (HP:0007973)1.57285689
147Aplasia of the musculature (HP:0100854)1.55102994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.04174197
2TLK13.92765400
3BUB13.73134450
4EIF2AK13.47069293
5STK162.92640129
6NME22.89052124
7PBK2.72559953
8VRK12.62341223
9SRPK12.50935929
10CASK2.49740360
11NEK12.46281608
12TRIM282.38953268
13TESK22.31519578
14WEE12.31305049
15MKNK12.18729325
16STK392.18504889
17NUAK12.09470362
18NME12.00704077
19EIF2AK31.95590684
20BCR1.89802510
21LIMK11.86600294
22TAF11.84189910
23PNCK1.83910046
24DYRK21.81627695
25UHMK11.79467753
26MKNK21.79335933
27MST41.65557656
28BCKDK1.61267928
29CDK191.55987403
30OXSR11.55513726
31PLK41.47450405
32MAPKAPK51.36807800
33CDC71.36146953
34PDK21.25258096
35CDK81.22952378
36CLK11.13819092
37PIM21.10415264
38CSNK1G31.08560175
39BMPR1B1.08131064
40DYRK31.07685415
41AURKA1.07579203
42MAP4K21.05164808
43TNIK1.03285799
44PLK31.01883266
45PAK40.96381256
46MAPK130.96338207
47KDR0.95507012
48PLK10.95279056
49DAPK10.94907150
50GRK50.89468130
51MARK10.89142408
52PKN10.88478814
53CDK70.86561449
54GRK70.85967565
55PLK20.84276686
56YES10.83245234
57EIF2AK20.80706090
58CAMK2B0.80297327
59RPS6KA50.79452725
60CCNB10.78904856
61BRAF0.78709916
62CDK140.78424700
63ADRBK20.75307335
64CSNK1G10.72229782
65ERBB40.71417794
66MAP3K120.69188916
67STK40.68653274
68CDK180.67995224
69AURKB0.67718680
70CHEK20.67509202
71CSNK2A10.66457129
72IRAK20.66396762
73EPHB20.66334754
74BRSK20.65934413
75ROCK20.65497865
76CDK150.64502356
77CDK11A0.64435981
78ADRBK10.63020169
79CSNK2A20.61182217
80TSSK60.61131983
81WNK40.60686767
82PAK10.59895016
83TTK0.59441411
84ARAF0.55142681
85FGR0.54700837
86CSNK1A1L0.54175622
87MAPK150.53962013
88MAP2K70.52857212
89DAPK30.52803236
90TESK10.52376519
91FLT30.52171729
92FES0.51925763
93ILK0.51363972
94NEK20.51020147
95CAMK2D0.50376775
96ABL20.49876459
97BRSK10.46463928
98NEK60.46093050
99PASK0.44227548
100SIK30.44086749
101MINK10.44053678
102CSNK1G20.43933878
103SCYL20.42613814
104MYLK0.41495930
105TGFBR10.41450721
106OBSCN0.41382665
107CAMK2A0.41127309
108WNK30.40610953
109SMG10.40233140
110ERBB30.39297194
111GRK10.38678183
112ATR0.38219359
113MUSK0.37812967
114CDK90.36686184
115DYRK1A0.36526261
116PRKCI0.36496218
117CAMK2G0.35572006
118CHEK10.34544941
119AKT30.34442375
120ZAK0.33850133
121CSNK1E0.33549328
122FGFR10.33541406
123STK30.33182824
124CDK10.32663769
125AKT20.31375263
126ATM0.28665687
127RPS6KB20.28077896
128CSNK1A10.27990882
129IRAK40.27815038
130RPS6KA40.26667942
131INSRR0.26645460

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.49306059
2Oxidative phosphorylation_Homo sapiens_hsa001904.06578632
3RNA polymerase_Homo sapiens_hsa030203.83770546
4Proteasome_Homo sapiens_hsa030503.69581847
5Parkinsons disease_Homo sapiens_hsa050123.64101894
6Protein export_Homo sapiens_hsa030602.94219076
7DNA replication_Homo sapiens_hsa030302.85156625
8Spliceosome_Homo sapiens_hsa030402.83431890
9Huntingtons disease_Homo sapiens_hsa050162.80119146
10Mismatch repair_Homo sapiens_hsa034302.70885991
11Alzheimers disease_Homo sapiens_hsa050102.59331563
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.53310541
13Homologous recombination_Homo sapiens_hsa034402.39474424
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24341336
15Pyrimidine metabolism_Homo sapiens_hsa002402.14162706
16Nucleotide excision repair_Homo sapiens_hsa034202.11747447
17Basal transcription factors_Homo sapiens_hsa030222.02065511
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97175260
19RNA transport_Homo sapiens_hsa030131.78301538
20Base excision repair_Homo sapiens_hsa034101.75815295
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71384716
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66236446
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65337346
24Fanconi anemia pathway_Homo sapiens_hsa034601.63522252
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58546914
26Cardiac muscle contraction_Homo sapiens_hsa042601.47632652
27Fatty acid elongation_Homo sapiens_hsa000621.45462594
28Pyruvate metabolism_Homo sapiens_hsa006201.44587489
29RNA degradation_Homo sapiens_hsa030181.40592376
30Propanoate metabolism_Homo sapiens_hsa006401.38292570
31Cell cycle_Homo sapiens_hsa041101.32600533
32Biosynthesis of amino acids_Homo sapiens_hsa012301.31033654
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26587078
34Purine metabolism_Homo sapiens_hsa002301.25524496
35Non-homologous end-joining_Homo sapiens_hsa034501.25324248
36Steroid biosynthesis_Homo sapiens_hsa001001.24579590
37Carbon metabolism_Homo sapiens_hsa012001.17091447
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13666988
39mRNA surveillance pathway_Homo sapiens_hsa030151.07471967
40Ether lipid metabolism_Homo sapiens_hsa005651.01937325
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97885251
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96138446
43One carbon pool by folate_Homo sapiens_hsa006700.96026343
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95906509
45Phototransduction_Homo sapiens_hsa047440.89893861
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88567026
47Selenocompound metabolism_Homo sapiens_hsa004500.87591098
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87134146
49Epstein-Barr virus infection_Homo sapiens_hsa051690.74251031
50Systemic lupus erythematosus_Homo sapiens_hsa053220.72594387
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69779961
52Vitamin B6 metabolism_Homo sapiens_hsa007500.69638367
53Butanoate metabolism_Homo sapiens_hsa006500.68855817
54Pentose phosphate pathway_Homo sapiens_hsa000300.67441028
55Arachidonic acid metabolism_Homo sapiens_hsa005900.66638596
56Alcoholism_Homo sapiens_hsa050340.66292721
57Fatty acid metabolism_Homo sapiens_hsa012120.64870879
58Oocyte meiosis_Homo sapiens_hsa041140.62954428
59N-Glycan biosynthesis_Homo sapiens_hsa005100.61948767
60Glutathione metabolism_Homo sapiens_hsa004800.60789092
61Serotonergic synapse_Homo sapiens_hsa047260.60208956
62Vibrio cholerae infection_Homo sapiens_hsa051100.59198473
63Hedgehog signaling pathway_Homo sapiens_hsa043400.59051756
64Peroxisome_Homo sapiens_hsa041460.57872600
65Metabolic pathways_Homo sapiens_hsa011000.57099664
66Sphingolipid metabolism_Homo sapiens_hsa006000.56541836
67Collecting duct acid secretion_Homo sapiens_hsa049660.56086436
68Axon guidance_Homo sapiens_hsa043600.53952278
69Folate biosynthesis_Homo sapiens_hsa007900.53603024
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51968481
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51967925
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51329185
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49792966
74p53 signaling pathway_Homo sapiens_hsa041150.48745935
75Basal cell carcinoma_Homo sapiens_hsa052170.48679059
76Sulfur relay system_Homo sapiens_hsa041220.46859433
77Linoleic acid metabolism_Homo sapiens_hsa005910.46408829
78beta-Alanine metabolism_Homo sapiens_hsa004100.44496730
79Nicotine addiction_Homo sapiens_hsa050330.43200583
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39332857
81Wnt signaling pathway_Homo sapiens_hsa043100.39145875
82Fatty acid degradation_Homo sapiens_hsa000710.38752523
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35657143
84Long-term depression_Homo sapiens_hsa047300.34892972
85Autoimmune thyroid disease_Homo sapiens_hsa053200.33276133
86Galactose metabolism_Homo sapiens_hsa000520.33066500
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31857354
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29944467
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29892837
90Nitrogen metabolism_Homo sapiens_hsa009100.29216791
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.28386384
92Arginine and proline metabolism_Homo sapiens_hsa003300.27174369
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26734808
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.25888763
95Hippo signaling pathway_Homo sapiens_hsa043900.25363138
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23022801
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22975695
98Tryptophan metabolism_Homo sapiens_hsa003800.22573976
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21756169
100TGF-beta signaling pathway_Homo sapiens_hsa043500.21608515
101Tight junction_Homo sapiens_hsa045300.20677897
102Asthma_Homo sapiens_hsa053100.20273712
103Fructose and mannose metabolism_Homo sapiens_hsa000510.20089296
104Regulation of autophagy_Homo sapiens_hsa041400.19004684
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18932998
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18189940
107Melanoma_Homo sapiens_hsa052180.17098346
108Phagosome_Homo sapiens_hsa041450.16378577
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15531965
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.15331231
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14466934
112Chemical carcinogenesis_Homo sapiens_hsa052040.14440509
113Dopaminergic synapse_Homo sapiens_hsa047280.14249642
114Tyrosine metabolism_Homo sapiens_hsa003500.13877988
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13741536
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13003572
117Rheumatoid arthritis_Homo sapiens_hsa053230.12355756
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12146406
119Fat digestion and absorption_Homo sapiens_hsa049750.11470162
120Melanogenesis_Homo sapiens_hsa049160.11258923
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11183201
122Gap junction_Homo sapiens_hsa045400.09820990
123Sulfur metabolism_Homo sapiens_hsa009200.09800469
124Allograft rejection_Homo sapiens_hsa053300.09201651
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.09178886
126Renal cell carcinoma_Homo sapiens_hsa052110.07114554
127Ras signaling pathway_Homo sapiens_hsa040140.06603214
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.06497915
129Taste transduction_Homo sapiens_hsa047420.05808059
130Viral carcinogenesis_Homo sapiens_hsa052030.05370089
131Pathways in cancer_Homo sapiens_hsa052000.04934268
132Glutamatergic synapse_Homo sapiens_hsa047240.04223117
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.03934908
134Cocaine addiction_Homo sapiens_hsa050300.03829514
135Amphetamine addiction_Homo sapiens_hsa050310.03558898

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