NUTM2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of gastrointestinal epithelium (GO:0030277)5.27621987
2regulation of ARF GTPase activity (GO:0032312)4.99699360
3epithelial structure maintenance (GO:0010669)4.17215638
4histone H3-K36 demethylation (GO:0070544)3.96529720
5mannose metabolic process (GO:0006013)3.86012484
6positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.83336250
7histone H3-K4 trimethylation (GO:0080182)3.77880514
8regulation of G0 to G1 transition (GO:0070316)3.75843256
9cellular response to epidermal growth factor stimulus (GO:0071364)3.69974397
10histone H3-K4 methylation (GO:0051568)3.60505800
11cytoplasmic mRNA processing body assembly (GO:0033962)3.58926615
12positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.52597358
13negative regulation of myotube differentiation (GO:0010832)3.52397501
14negative regulation of erythrocyte differentiation (GO:0045647)3.46310019
15retrograde transport, vesicle recycling within Golgi (GO:0000301)3.41086463
16establishment of protein localization to Golgi (GO:0072600)3.39993866
17response to muramyl dipeptide (GO:0032495)3.39154319
18positive regulation of gamma-delta T cell activation (GO:0046645)3.34061026
19response to epidermal growth factor (GO:0070849)3.33778783
20positive regulation of granulocyte differentiation (GO:0030854)3.26760860
21protein targeting to Golgi (GO:0000042)3.22422515
22corticosteroid receptor signaling pathway (GO:0031958)3.19031123
23histone lysine methylation (GO:0034968)3.18802066
24regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.17077555
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.14611903
26cellular extravasation (GO:0045123)3.13506387
27histone lysine demethylation (GO:0070076)3.07589764
28positive regulation of CREB transcription factor activity (GO:0032793)3.04831601
29histone demethylation (GO:0016577)3.02196049
30interkinetic nuclear migration (GO:0022027)3.02000202
31striated muscle atrophy (GO:0014891)2.99364096
32response to vitamin A (GO:0033189)2.98578442
33regulation of gamma-delta T cell differentiation (GO:0045586)2.94910083
34TOR signaling (GO:0031929)2.94742804
35response to misfolded protein (GO:0051788)2.93954796
36regulation of histone H3-K27 methylation (GO:0061085)2.92958962
37regulation of gamma-delta T cell activation (GO:0046643)2.89043592
38insulin-like growth factor receptor signaling pathway (GO:0048009)2.88868758
39skeletal muscle adaptation (GO:0043501)2.85991906
40negative regulation of translation, ncRNA-mediated (GO:0040033)2.83875890
41regulation of translation, ncRNA-mediated (GO:0045974)2.83875890
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83875890
43glucocorticoid receptor signaling pathway (GO:0042921)2.83449710
44cellular response to ethanol (GO:0071361)2.81495509
45regulation of MHC class I biosynthetic process (GO:0045343)2.80757918
46detection of molecule of bacterial origin (GO:0032490)2.80575968
47thymic T cell selection (GO:0045061)2.79061837
48histone H3-K9 modification (GO:0061647)2.77023621
49regulation of NFAT protein import into nucleus (GO:0051532)2.75115408
50definitive hemopoiesis (GO:0060216)2.72737686
51phospholipid scrambling (GO:0017121)2.71723732
52histone H3-K9 demethylation (GO:0033169)2.70437565
53monoubiquitinated protein deubiquitination (GO:0035520)2.69934433
54O-glycan processing (GO:0016266)2.67032922
55cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.66904855
56peptidyl-lysine trimethylation (GO:0018023)2.66679021
57positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.63370460
58atrioventricular valve morphogenesis (GO:0003181)2.59283514
59positive regulation of histone deacetylation (GO:0031065)2.58541911
60protein localization to Golgi apparatus (GO:0034067)2.56945880
61regulation of fatty acid beta-oxidation (GO:0031998)2.55121479
62cerebellar Purkinje cell differentiation (GO:0021702)2.53823863
63regulation of interleukin-12 biosynthetic process (GO:0045075)2.53153595
64regulation of ARF protein signal transduction (GO:0032012)2.52660707
65muscle atrophy (GO:0014889)2.52472060
66regulation of granulocyte differentiation (GO:0030852)2.51639275
67regulation of necroptotic process (GO:0060544)2.51625226
68T cell selection (GO:0045058)2.50992960
69receptor catabolic process (GO:0032801)2.50688231
70negative regulation of fatty acid transport (GO:2000192)2.50452197
71neural tube development (GO:0021915)2.48584630
72protein dealkylation (GO:0008214)2.47257077
73protein demethylation (GO:0006482)2.47257077
74phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.46130910
75venous blood vessel morphogenesis (GO:0048845)2.45462908
76negative T cell selection (GO:0043383)2.43243826
77positive regulation of Rap GTPase activity (GO:0032854)2.42621312
78negative thymic T cell selection (GO:0045060)2.42128141
79phospholipid translocation (GO:0045332)2.42035520
80lipid translocation (GO:0034204)2.42035520
81focal adhesion assembly (GO:0048041)2.41701657
82cell-substrate adherens junction assembly (GO:0007045)2.41701657
83peptidyl-lysine methylation (GO:0018022)2.41092808
84regulation of RNA export from nucleus (GO:0046831)2.38840973
85positive regulation of protein kinase C signaling (GO:0090037)2.38163495
86positive thymic T cell selection (GO:0045059)2.37998672
87activation of Rac GTPase activity (GO:0032863)2.37553001
88histone methylation (GO:0016571)2.37547861
89apoptotic process involved in morphogenesis (GO:0060561)2.37170173
90response to laminar fluid shear stress (GO:0034616)2.34496894
91positive T cell selection (GO:0043368)2.34173379
92positive regulation of protein deacetylation (GO:0090312)2.33540514
93N-terminal protein amino acid acetylation (GO:0006474)2.32044963
94histone H3-K9 methylation (GO:0051567)2.31264636
95negative regulation of digestive system process (GO:0060457)2.31082400
96response to peptidoglycan (GO:0032494)2.29953705
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28006919
98positive regulation by host of viral transcription (GO:0043923)2.27684965
99macrophage activation involved in immune response (GO:0002281)2.26945101
100positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.25356353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.18626070
2CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.94821041
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.92417426
4DROSHA_22980978_ChIP-Seq_HELA_Human2.91824929
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.80704027
6MYC_22102868_ChIP-Seq_BL_Human2.79602699
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.72297485
8SCL_19346495_ChIP-Seq_HPC-7_Human2.66020443
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.48307312
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.43805558
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37014727
12KDM2B_26808549_Chip-Seq_DND41_Human2.31259118
13TCF7_22412390_ChIP-Seq_EML_Mouse2.28397331
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.19082516
15LXR_22292898_ChIP-Seq_THP-1_Human2.16484013
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.10628309
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09711335
18VDR_24763502_ChIP-Seq_THP-1_Human1.92549285
19GATA1_19941827_ChIP-Seq_MEL_Mouse1.91657604
20KDM2B_26808549_Chip-Seq_K562_Human1.90395338
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89832451
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.89755347
23GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.87444988
24SPI1_23127762_ChIP-Seq_K562_Human1.86536182
25KDM2B_26808549_Chip-Seq_JURKAT_Human1.84418850
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83981200
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.79532967
28MAF_26560356_Chip-Seq_TH1_Human1.77057110
29RACK7_27058665_Chip-Seq_MCF-7_Human1.76235405
30GATA1_19941826_ChIP-Seq_K562_Human1.75097782
31MAF_26560356_Chip-Seq_TH2_Human1.73012854
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.71028048
33GATA1_22025678_ChIP-Seq_K562_Human1.70317799
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.68638667
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64142949
36SMC4_20622854_ChIP-Seq_HELA_Human1.62350944
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59975740
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58179752
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56649224
40UTX_26944678_Chip-Seq_JUKART_Human1.55749299
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.53539012
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52741339
43RUNX_20019798_ChIP-Seq_JUKART_Human1.51738350
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51320676
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49172520
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47709661
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44647826
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42703855
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42373851
50P68_20966046_ChIP-Seq_HELA_Human1.40463785
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37121148
52GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34881188
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.34636395
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33011878
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32885315
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32659771
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32518922
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29833578
59CREB1_26743006_Chip-Seq_LNCaP_Human1.27876322
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27354980
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26468870
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26253662
63GATA2_19941826_ChIP-Seq_K562_Human1.25882263
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.25440474
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25061251
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23618986
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.22230917
68AHR_22903824_ChIP-Seq_MCF-7_Human1.21939748
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21114225
70AR_21572438_ChIP-Seq_LNCaP_Human1.19924479
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.19480748
72TP63_22573176_ChIP-Seq_HFKS_Human1.18555119
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18029579
74TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17935474
75CTCF_27219007_Chip-Seq_Bcells_Human1.17871380
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16848495
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15841980
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15713282
79BCOR_27268052_Chip-Seq_Bcells_Human1.14912978
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13720124
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13136781
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11542990
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09806531
84OCT4_19829295_ChIP-Seq_ESCs_Human1.06857353
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.04242254
86MYB_26560356_Chip-Seq_TH1_Human1.03542903
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02816644
88BCL6_27268052_Chip-Seq_Bcells_Human1.01810546
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01305477
90TP53_22127205_ChIP-Seq_IMR90_Human1.01249882
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.98616981
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98087332
93E2F1_20622854_ChIP-Seq_HELA_Human0.97390297
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97148248
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96949867
96UBF1/2_26484160_Chip-Seq_HMECs_Human0.95551442
97NCOR1_26117541_ChIP-Seq_K562_Human0.94867493
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94269971
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93741999
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92219781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland3.98735812
2MP0003705_abnormal_hypodermis_morpholog3.44394530
3MP0005076_abnormal_cell_differentiation3.25469423
4MP0005083_abnormal_biliary_tract3.15019402
5MP0008004_abnormal_stomach_pH2.59781772
6MP0003763_abnormal_thymus_physiology2.55189186
7MP0000465_gastrointestinal_hemorrhage2.54041869
8MP0003091_abnormal_cell_migration2.50874787
9MP0002396_abnormal_hematopoietic_system2.50719319
10MP0003436_decreased_susceptibility_to2.42596400
11MP0008057_abnormal_DNA_replication2.36538046
12MP0003866_abnormal_defecation2.34950109
13MP0000569_abnormal_digit_pigmentation2.19303012
14MP0003279_aneurysm2.19248661
15MP0003172_abnormal_lysosome_physiology2.17223332
16MP0003045_fibrosis2.14004539
17MP0004043_abnormal_pH_regulation1.97079766
18MP0005058_abnormal_lysosome_morphology1.82094954
19MP0003303_peritoneal_inflammation1.80068753
20MP0002249_abnormal_larynx_morphology1.75979264
21MP0008438_abnormal_cutaneous_collagen1.75898554
22MP0009278_abnormal_bone_marrow1.75511467
23MP0005451_abnormal_body_composition1.73072124
24MP0003879_abnormal_hair_cell1.70510613
25MP0008961_abnormal_basal_metabolism1.64985609
26MP0005310_abnormal_salivary_gland1.59901519
27MP0004381_abnormal_hair_follicle1.59547764
28MP0004808_abnormal_hematopoietic_stem1.59101750
29MP0005409_darkened_coat_color1.58470661
30MP0001545_abnormal_hematopoietic_system1.57307734
31MP0005397_hematopoietic_system_phenotyp1.57307734
32MP0000566_synostosis1.52207125
33MP0010155_abnormal_intestine_physiology1.49106542
34MP0001664_abnormal_digestion1.49031584
35MP0005275_abnormal_skin_tensile1.44090164
36MP0003300_gastrointestinal_ulcer1.38519399
37MP0001851_eye_inflammation1.33059348
38MP0001800_abnormal_humoral_immune1.24520761
39MP0009840_abnormal_foam_cell1.21858098
40MP0004233_abnormal_muscle_weight1.19098498
41MP0003656_abnormal_erythrocyte_physiolo1.18698237
42MP0004130_abnormal_muscle_cell1.18181451
43MP0001663_abnormal_digestive_system1.18007837
44MP0003828_pulmonary_edema1.14106175
45MP0004947_skin_inflammation1.13721838
46MP0002060_abnormal_skin_morphology1.12828072
47MP0003878_abnormal_ear_physiology1.10944569
48MP0005377_hearing/vestibular/ear_phenot1.10944569
49MP0002398_abnormal_bone_marrow1.09908885
50MP0005220_abnormal_exocrine_pancreas1.06336458
51MP0000703_abnormal_thymus_morphology1.06145017
52MP0000470_abnormal_stomach_morphology1.04844464
53MP0005381_digestive/alimentary_phenotyp1.04157787
54MP0001835_abnormal_antigen_presentation1.01339840
55MP0005621_abnormal_cell_physiology1.01266333
56MP0002089_abnormal_postnatal_growth/wei0.99364672
57MP0001958_emphysema0.99172926
58MP0002933_joint_inflammation0.96407756
59MP0002822_catalepsy0.96179792
60MP0008995_early_reproductive_senescence0.95958747
61MP0003329_amyloid_beta_deposits0.95094966
62MP0000538_abnormal_urinary_bladder0.93980598
63MP0002970_abnormal_white_adipose0.93322196
64MP0003646_muscle_fatigue0.93049159
65MP0002419_abnormal_innate_immunity0.92075528
66MP0003453_abnormal_keratinocyte_physiol0.92042788
67MP0002420_abnormal_adaptive_immunity0.90365453
68MP0001819_abnormal_immune_cell0.89992585
69MP0002452_abnormal_antigen_presenting0.89824217
70MP0002998_abnormal_bone_remodeling0.88560360
71MP0009115_abnormal_fat_cell0.87463933
72MP0001765_abnormal_ion_homeostasis0.86412974
73MP0002928_abnormal_bile_duct0.86384164
74MP0002722_abnormal_immune_system0.85822302
75MP0001661_extended_life_span0.85658055
76MP0000685_abnormal_immune_system0.85406121
77MP0003183_abnormal_peptide_metabolism0.85224192
78MP0000733_abnormal_muscle_development0.84150850
79MP0002168_other_aberrant_phenotype0.83843022
80MP0005025_abnormal_response_to0.83815737
81MP0000716_abnormal_immune_system0.83139068
82MP0002405_respiratory_system_inflammati0.82712730
83MP0002723_abnormal_immune_serum0.81193473
84MP0000747_muscle_weakness0.80886169
85MP0005174_abnormal_tail_pigmentation0.80279975
86MP0002332_abnormal_exercise_endurance0.77936364
87MP0001299_abnormal_eye_distance/0.77041800
88MP0002009_preneoplasia0.76227897
89MP0001790_abnormal_immune_system0.75359823
90MP0005387_immune_system_phenotype0.75359823
91MP0009931_abnormal_skin_appearance0.75305016
92MP0000371_diluted_coat_color0.74871629
93MP0003943_abnormal_hepatobiliary_system0.74246396
94MP0004264_abnormal_extraembryonic_tissu0.74239123
95MP0000759_abnormal_skeletal_muscle0.73568135
96MP0006138_congestive_heart_failure0.73130359
97MP0002108_abnormal_muscle_morphology0.71523356
98MP0004036_abnormal_muscle_relaxation0.71445630
99MP0000579_abnormal_nail_morphology0.70815529
100MP0005448_abnormal_energy_balance0.69714647

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.58984436
2Broad face (HP:0000283)3.92517972
3Cerebral aneurysm (HP:0004944)3.51549693
4Thin bony cortex (HP:0002753)3.39145249
5Long eyelashes (HP:0000527)3.25438129
6Abnormality of the columella (HP:0009929)3.24813462
7Narrow palate (HP:0000189)2.87146438
8Genetic anticipation (HP:0003743)2.79967493
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.79668109
10Hemorrhage of the eye (HP:0011885)2.74813233
11Dysmetric saccades (HP:0000641)2.63976134
12Obstructive sleep apnea (HP:0002870)2.62854538
13Mask-like facies (HP:0000298)2.59785384
14Hyperacusis (HP:0010780)2.55475090
15Colitis (HP:0002583)2.50925740
16Prominent nose (HP:0000448)2.50651421
17Abnormal pancreas size (HP:0012094)2.45372568
18Hyperkalemia (HP:0002153)2.41845729
19Mitral valve prolapse (HP:0001634)2.37510446
20Sandal gap (HP:0001852)2.33379044
21Malnutrition (HP:0004395)2.31612670
22Heterotopia (HP:0002282)2.31331492
23Tibial bowing (HP:0002982)2.30601658
24Self-mutilation (HP:0000742)2.30558074
25Ulnar bowing (HP:0003031)2.29312415
26Lip pit (HP:0100267)2.28851066
27Dislocated radial head (HP:0003083)2.21108290
28Abnormality of the distal phalanx of the thumb (HP:0009617)2.20624221
29Truncal obesity (HP:0001956)2.19986025
30Urethral obstruction (HP:0000796)2.17592637
31Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.17146279
32Vertebral arch anomaly (HP:0008438)2.14076485
33Clumsiness (HP:0002312)2.12721402
34Neonatal hypoglycemia (HP:0001998)2.11371354
35Spondylolisthesis (HP:0003302)2.10310381
36Abnormality of incisor morphology (HP:0011063)2.10171652
37Genu recurvatum (HP:0002816)2.10081535
38Short nail (HP:0001799)2.09567373
39Annular pancreas (HP:0001734)2.08724194
40Aortic aneurysm (HP:0004942)2.05567877
41Increased connective tissue (HP:0009025)2.03153175
42Aneurysm (HP:0002617)2.02452218
43Distal lower limb amyotrophy (HP:0008944)2.02187141
44Abnormality of the radial head (HP:0003995)2.02027713
45Sparse lateral eyebrow (HP:0005338)2.00761062
46Spinal muscular atrophy (HP:0007269)1.93364839
47Fragile skin (HP:0001030)1.93014880
48Duplicated collecting system (HP:0000081)1.90670361
49Onion bulb formation (HP:0003383)1.90070742
50Bilateral sensorineural hearing impairment (HP:0008619)1.87618224
51Rectal prolapse (HP:0002035)1.86859797
52Chromsome breakage (HP:0040012)1.85858757
53Ectopic kidney (HP:0000086)1.85793617
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85623824
55Abnormality of dentin (HP:0010299)1.83497647
56Disproportionate tall stature (HP:0001519)1.83489173
57Mild short stature (HP:0003502)1.83083519
58Laryngomalacia (HP:0001601)1.82767464
59Autoimmune thrombocytopenia (HP:0001973)1.82355344
60Depressed nasal tip (HP:0000437)1.80188094
61Enlarged epiphyses (HP:0010580)1.79628308
62Joint laxity (HP:0001388)1.79105098
63Peritonitis (HP:0002586)1.78924648
64Abnormality of DNA repair (HP:0003254)1.78661939
65Inflammation of the large intestine (HP:0002037)1.76336547
66Premature skin wrinkling (HP:0100678)1.76136756
67Flat occiput (HP:0005469)1.75830086
68Pili torti (HP:0003777)1.73784877
69Upper limb amyotrophy (HP:0009129)1.72877035
70Distal upper limb amyotrophy (HP:0007149)1.72877035
71Abnormality of the nasal septum (HP:0000419)1.72544697
72Ankyloglossia (HP:0010296)1.72442220
73Gastrointestinal inflammation (HP:0004386)1.72096101
74Persistence of primary teeth (HP:0006335)1.70827246
75Aortic dissection (HP:0002647)1.70553414
76Abnormality of the renal collecting system (HP:0004742)1.69655268
77Abnormality of the thoracic spine (HP:0100711)1.68963037
78Bronchomalacia (HP:0002780)1.68186275
79Thoracic kyphosis (HP:0002942)1.67100189
80Spontaneous hematomas (HP:0007420)1.66984009
81Overgrowth (HP:0001548)1.66050746
82Acute myeloid leukemia (HP:0004808)1.65458370
83Smooth philtrum (HP:0000319)1.64567051
84Tracheomalacia (HP:0002779)1.63085260
85Atrophic scars (HP:0001075)1.63049511
86Germ cell neoplasia (HP:0100728)1.62192376
87Dilatation of the ascending aorta (HP:0005111)1.61976859
88Segmental peripheral demyelination/remyelination (HP:0003481)1.60784470
89Abnormality of chloride homeostasis (HP:0011422)1.59854862
90Thick eyebrow (HP:0000574)1.59627518
91Flat acetabular roof (HP:0003180)1.58680357
92Natal tooth (HP:0000695)1.56345612
93Prolonged bleeding time (HP:0003010)1.55403290
94Acute lymphatic leukemia (HP:0006721)1.52057129
95Abnormality of the aortic arch (HP:0012303)1.51880827
96Lower limb amyotrophy (HP:0007210)1.51859493
97Progressive cerebellar ataxia (HP:0002073)1.51666066
98Slow saccadic eye movements (HP:0000514)1.51277404
99Neonatal short-limb short stature (HP:0008921)1.51216595
100Eczematoid dermatitis (HP:0000976)1.51182632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.38723639
2TRIB33.52844875
3ICK3.23769096
4MST1R3.05876246
5WNK42.42667624
6BLK2.39581219
7CAMK1D2.29111207
8WNK12.28551596
9ERN11.90954224
10MARK21.90147121
11MAP2K31.89908299
12SIK11.84653499
13PRPF4B1.83449646
14MAP3K131.83422061
15EEF2K1.82039703
16CAMK1G1.73923653
17SIK21.71537627
18MTOR1.61639167
19NME11.61540358
20MAP3K71.52007738
21BRD41.46959401
22CDC42BPA1.44077420
23AKT31.31889130
24TRPM71.24855795
25MAP4K11.18364508
26ZAP701.05610568
27NEK21.04043345
28MELK0.97161034
29BTK0.96450619
30TTN0.94276136
31MAPK110.93993329
32MAPK150.93962160
33ACVR1B0.93590999
34FGFR40.90925906
35FRK0.90524593
36PKN20.90414432
37TNK20.87240650
38RIPK40.87221583
39CHUK0.87108156
40MAP3K100.86122628
41CAMKK10.83261687
42TAOK10.82759664
43MAPK120.82717888
44CAMK40.82694236
45PDGFRB0.81330293
46MAP3K60.80173490
47MARK30.78324466
48RIPK10.77969380
49RET0.77942266
50MET0.77165942
51PRKAA20.76753806
52MAP3K10.74315550
53SGK20.71848419
54RPS6KL10.71752264
55RPS6KC10.71752264
56TESK20.71290046
57MAP2K60.70724872
58RPS6KA60.70587561
59ERBB20.69423491
60SMG10.69333743
61FES0.69241745
62TYK20.68933733
63HIPK20.68238223
64PRKD20.66230893
65FGFR30.64072919
66PRKAA10.63250783
67HCK0.63171300
68SGK30.62441707
69KSR20.61869252
70IRAK40.61097139
71NLK0.60336097
72TYRO30.60198436
73MAP3K30.59854399
74MAP3K110.58935506
75SGK10.58644562
76GRK60.57873481
77RPS6KA20.57381254
78PDPK10.57144584
79EPHB10.56974733
80SGK2230.54646376
81SGK4940.54646376
82PIK3CG0.54005352
83CDK40.53910955
84IKBKE0.51651218
85PDGFRA0.51380761
86SYK0.49424601
87PDK10.48331571
88CSF1R0.47935214
89PRKCH0.47799608
90AKT10.47173831
91MAP3K140.46008875
92ITK0.45931120
93CSK0.45751405
94MAPK10.45084726
95MAPK70.42097108
96LCK0.41662300
97JAK10.41415796
98MAP2K20.41360397
99EPHA30.41212275
100IRAK20.40896350

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.30675919
2Acute myeloid leukemia_Homo sapiens_hsa052211.87181840
3Notch signaling pathway_Homo sapiens_hsa043301.74494772
4Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73866611
5Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73653235
6Phosphatidylinositol signaling system_Homo sapiens_hsa040701.59914666
7B cell receptor signaling pathway_Homo sapiens_hsa046621.59343421
8VEGF signaling pathway_Homo sapiens_hsa043701.59089331
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56925287
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55244190
11Chronic myeloid leukemia_Homo sapiens_hsa052201.54749657
12Type II diabetes mellitus_Homo sapiens_hsa049301.53404870
13Osteoclast differentiation_Homo sapiens_hsa043801.52795908
14Non-small cell lung cancer_Homo sapiens_hsa052231.52220332
15Other glycan degradation_Homo sapiens_hsa005111.47524880
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44680079
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40642185
18Platelet activation_Homo sapiens_hsa046111.36329871
19mTOR signaling pathway_Homo sapiens_hsa041501.35482331
20Inositol phosphate metabolism_Homo sapiens_hsa005621.32956765
21T cell receptor signaling pathway_Homo sapiens_hsa046601.30475169
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27819395
23ErbB signaling pathway_Homo sapiens_hsa040121.25567481
24GnRH signaling pathway_Homo sapiens_hsa049121.24344033
25ABC transporters_Homo sapiens_hsa020101.23829916
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21224156
27Dorso-ventral axis formation_Homo sapiens_hsa043201.13294590
28TNF signaling pathway_Homo sapiens_hsa046681.11493766
29Choline metabolism in cancer_Homo sapiens_hsa052311.10657708
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10446105
31Prolactin signaling pathway_Homo sapiens_hsa049171.10272739
32Pancreatic cancer_Homo sapiens_hsa052121.09326326
33Endometrial cancer_Homo sapiens_hsa052131.09192355
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08675630
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07213145
36FoxO signaling pathway_Homo sapiens_hsa040681.06330988
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.04965647
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04328392
39Renal cell carcinoma_Homo sapiens_hsa052111.03854486
40Hepatitis B_Homo sapiens_hsa051611.03244580
41Prostate cancer_Homo sapiens_hsa052151.00682428
42Neurotrophin signaling pathway_Homo sapiens_hsa047220.99447385
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.99183215
44Toxoplasmosis_Homo sapiens_hsa051450.99145843
45Insulin resistance_Homo sapiens_hsa049310.98324890
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97464523
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96072282
48MicroRNAs in cancer_Homo sapiens_hsa052060.95529778
49Leishmaniasis_Homo sapiens_hsa051400.95192626
50Small cell lung cancer_Homo sapiens_hsa052220.93502800
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91904299
52Ovarian steroidogenesis_Homo sapiens_hsa049130.91350877
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.91140585
54Amoebiasis_Homo sapiens_hsa051460.90716233
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89785076
56Apoptosis_Homo sapiens_hsa042100.88688579
57MAPK signaling pathway_Homo sapiens_hsa040100.86907389
58Estrogen signaling pathway_Homo sapiens_hsa049150.85949912
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85509088
60Colorectal cancer_Homo sapiens_hsa052100.84445142
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.84338134
62Influenza A_Homo sapiens_hsa051640.83567703
63Glioma_Homo sapiens_hsa052140.82987105
64Focal adhesion_Homo sapiens_hsa045100.82715153
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.80059208
66Cholinergic synapse_Homo sapiens_hsa047250.79623924
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78067630
68Insulin signaling pathway_Homo sapiens_hsa049100.77661916
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75642227
70ECM-receptor interaction_Homo sapiens_hsa045120.74557230
71Hepatitis C_Homo sapiens_hsa051600.72853683
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.71459283
73Tuberculosis_Homo sapiens_hsa051520.71245459
74Measles_Homo sapiens_hsa051620.68279514
75AMPK signaling pathway_Homo sapiens_hsa041520.66976661
76Salivary secretion_Homo sapiens_hsa049700.65746587
77Viral carcinogenesis_Homo sapiens_hsa052030.65119171
78Fructose and mannose metabolism_Homo sapiens_hsa000510.65080153
79Calcium signaling pathway_Homo sapiens_hsa040200.64457519
80Oxytocin signaling pathway_Homo sapiens_hsa049210.62487184
81Malaria_Homo sapiens_hsa051440.62432532
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61276166
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60686241
84Long-term potentiation_Homo sapiens_hsa047200.60212018
85Bladder cancer_Homo sapiens_hsa052190.59015091
86Glucagon signaling pathway_Homo sapiens_hsa049220.58635275
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.55794653
88Long-term depression_Homo sapiens_hsa047300.54703837
89Proteoglycans in cancer_Homo sapiens_hsa052050.54491800
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53829882
91Adherens junction_Homo sapiens_hsa045200.53745267
92HIF-1 signaling pathway_Homo sapiens_hsa040660.53739991
93Herpes simplex infection_Homo sapiens_hsa051680.53702027
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.53637075
95Chemokine signaling pathway_Homo sapiens_hsa040620.53596036
96Taste transduction_Homo sapiens_hsa047420.52935820
97Fatty acid biosynthesis_Homo sapiens_hsa000610.52646731
98Staphylococcus aureus infection_Homo sapiens_hsa051500.51573299
99Dilated cardiomyopathy_Homo sapiens_hsa054140.51024450
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.50921840

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