NUTM2E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to misfolded protein (GO:0051788)9.99595833
2dendritic spine morphogenesis (GO:0060997)7.14202996
3regulation of plasminogen activation (GO:0010755)6.76524729
4superoxide anion generation (GO:0042554)6.52510657
5ncRNA 3-end processing (GO:0043628)5.33312281
6negative regulation of translation, ncRNA-mediated (GO:0040033)5.19185864
7regulation of translation, ncRNA-mediated (GO:0045974)5.19185864
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.19185864
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.97709355
10protein autoprocessing (GO:0016540)4.80880192
11cytoplasmic mRNA processing body assembly (GO:0033962)4.70140234
12retinal rod cell development (GO:0046548)4.52857516
13regulation of fibrinolysis (GO:0051917)4.09707586
14interferon-gamma production (GO:0032609)3.90076828
15dendritic spine organization (GO:0097061)3.89859817
16neutrophil mediated immunity (GO:0002446)3.79779345
17negative regulation of Rho protein signal transduction (GO:0035024)3.73669382
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.68148326
19positive regulation of granulocyte differentiation (GO:0030854)3.67542004
20regulation of proton transport (GO:0010155)3.60778524
21negative regulation of erythrocyte differentiation (GO:0045647)3.53676526
22nerve development (GO:0021675)3.39111399
23histone H3-K36 demethylation (GO:0070544)3.38977602
24negative regulation of cell cycle arrest (GO:0071157)3.36036767
25photoreceptor cell maintenance (GO:0045494)3.31683001
26cell migration in hindbrain (GO:0021535)3.30446342
27venous blood vessel morphogenesis (GO:0048845)3.28244549
28regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27141440
29fibrinolysis (GO:0042730)3.25900917
30histone lysine methylation (GO:0034968)3.25026641
31N-terminal protein amino acid acetylation (GO:0006474)3.24370568
32regulation of ARF GTPase activity (GO:0032312)3.24315450
33negative regulation of glycoprotein biosynthetic process (GO:0010561)3.22694613
34mannose metabolic process (GO:0006013)3.20050773
35positive regulation of protein kinase C signaling (GO:0090037)3.03095317
36myeloid leukocyte mediated immunity (GO:0002444)2.99714676
37positive regulation of catecholamine secretion (GO:0033605)2.94100433
38activated T cell proliferation (GO:0050798)2.93879506
39regulation of granulocyte differentiation (GO:0030852)2.92478043
40regulation of respiratory system process (GO:0044065)2.90526125
41urogenital system development (GO:0001655)2.88092110
42cranial nerve morphogenesis (GO:0021602)2.86635082
43dendrite development (GO:0016358)2.85243531
44ventricular system development (GO:0021591)2.84050562
45endoderm formation (GO:0001706)2.83387254
46TOR signaling (GO:0031929)2.83125082
47relaxation of smooth muscle (GO:0044557)2.82312880
48histone H3-K4 methylation (GO:0051568)2.78756373
49histone H3-K4 trimethylation (GO:0080182)2.76406648
50phospholipid dephosphorylation (GO:0046839)2.74375131
51superoxide metabolic process (GO:0006801)2.73769954
52post-embryonic morphogenesis (GO:0009886)2.62640683
53histone H3-K9 modification (GO:0061647)2.62559413
54dopaminergic neuron differentiation (GO:0071542)2.60310091
55positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.60015097
56positive regulation of hemostasis (GO:1900048)2.59173493
57positive regulation of blood coagulation (GO:0030194)2.59173493
58cellular extravasation (GO:0045123)2.58367996
59endothelial cell proliferation (GO:0001935)2.54771577
60regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.52828399
61lipid phosphorylation (GO:0046834)2.51866968
62regulation of MHC class I biosynthetic process (GO:0045343)2.51022395
63corticosteroid receptor signaling pathway (GO:0031958)2.50651880
64snRNA transcription (GO:0009301)2.50291683
65sex determination (GO:0007530)2.45267557
66phosphatidylinositol dephosphorylation (GO:0046856)2.43634284
67phosphatidylinositol 3-kinase signaling (GO:0014065)2.42847772
68response to muramyl dipeptide (GO:0032495)2.42424852
69phosphatidylinositol phosphorylation (GO:0046854)2.42424221
70regulation of respiratory gaseous exchange (GO:0043576)2.42358773
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.40964369
72positive regulation of CREB transcription factor activity (GO:0032793)2.40676977
73negative regulation of Ras protein signal transduction (GO:0046580)2.40673291
74prepulse inhibition (GO:0060134)2.40626889
75positive regulation of coagulation (GO:0050820)2.40332766
76lens fiber cell differentiation (GO:0070306)2.39339862
77hydrogen peroxide biosynthetic process (GO:0050665)2.38975608
78Rap protein signal transduction (GO:0032486)2.38539827
79histone H3 deacetylation (GO:0070932)2.38454751
80alpha-beta T cell differentiation involved in immune response (GO:0002293)2.37679563
81alpha-beta T cell activation involved in immune response (GO:0002287)2.37679563
82T cell differentiation involved in immune response (GO:0002292)2.37679563
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37400172
84phospholipid scrambling (GO:0017121)2.36217624
85blood coagulation, intrinsic pathway (GO:0007597)2.35609330
86regulation of NFAT protein import into nucleus (GO:0051532)2.33833277
87cerebellar Purkinje cell differentiation (GO:0021702)2.33774992
88negative regulation of small GTPase mediated signal transduction (GO:0051058)2.31816253
89face development (GO:0060324)2.28967203
90misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.26062584
91positive regulation of acute inflammatory response (GO:0002675)2.24925207
92regulation of autophagic vacuole assembly (GO:2000785)2.24293971
93cytokine secretion (GO:0050663)2.23143294
94embryonic viscerocranium morphogenesis (GO:0048703)2.22624913
95neural crest cell migration (GO:0001755)2.22231996
96olfactory bulb development (GO:0021772)2.20130879
97positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.19423052
98G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.19320875
99granulocyte activation (GO:0036230)2.15563689
100negative regulation of catenin import into nucleus (GO:0035414)2.13555571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.29978974
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.27638714
3VDR_21846776_ChIP-Seq_THP-1_Human3.10415355
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.96487747
5DROSHA_22980978_ChIP-Seq_HELA_Human2.72268587
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.64719547
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.55258655
8SCL_19346495_ChIP-Seq_HPC-7_Human2.50004485
9KDM2B_26808549_Chip-Seq_DND41_Human2.48631962
10EZH2_22144423_ChIP-Seq_EOC_Human2.46440575
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43723151
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.40066433
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.32083895
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08590973
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06320272
16MYC_22102868_ChIP-Seq_BL_Human2.02005356
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98615580
18KDM2B_26808549_Chip-Seq_JURKAT_Human1.94527900
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93142211
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91428797
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.90720394
22TCF7_22412390_ChIP-Seq_EML_Mouse1.90265816
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87404938
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86715367
25AR_21572438_ChIP-Seq_LNCaP_Human1.85584746
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85058700
27MAF_26560356_Chip-Seq_TH2_Human1.73322117
28LXR_22292898_ChIP-Seq_THP-1_Human1.71806625
29KDM2B_26808549_Chip-Seq_K562_Human1.71389754
30MAF_26560356_Chip-Seq_TH1_Human1.65564239
31VDR_24763502_ChIP-Seq_THP-1_Human1.61302013
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59756923
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57382206
34MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.55935961
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.51006713
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50967680
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38305492
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38038207
39CTCF_27219007_Chip-Seq_Bcells_Human1.37691521
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36618694
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35216029
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33617973
43P68_20966046_ChIP-Seq_HELA_Human1.33067905
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30542104
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30227481
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29429651
47MYC_27129775_Chip-Seq_CORNEA_Mouse1.26851811
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26199014
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.25565609
50CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24676684
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.23000811
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.22906229
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.21929644
54RACK7_27058665_Chip-Seq_MCF-7_Human1.21448484
55CREB1_26743006_Chip-Seq_LNCaP_Human1.20287724
56RXR_22108803_ChIP-Seq_LS180_Human1.18322876
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.18120568
58SMC4_20622854_ChIP-Seq_HELA_Human1.16239022
59UTX_26944678_Chip-Seq_JUKART_Human1.14811230
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14303181
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13771352
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13583604
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13583604
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.13393065
65ERA_21632823_ChIP-Seq_H3396_Human1.13146452
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.13047565
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12181864
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.11130531
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10770737
70TP63_22573176_ChIP-Seq_HFKS_Human1.10611070
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.09462113
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08502658
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08397989
74E2F1_20622854_ChIP-Seq_HELA_Human1.07601430
75GATA2_19941826_ChIP-Seq_K562_Human1.06025991
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.05812314
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.04411836
78TFEB_21752829_ChIP-Seq_HELA_Human1.01593758
79TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01243944
80OCT4_19829295_ChIP-Seq_ESCs_Human1.01230959
81AHR_22903824_ChIP-Seq_MCF-7_Human1.01061894
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00789972
83GATA1_19941826_ChIP-Seq_K562_Human1.00672828
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99867588
85PHF8_20622854_ChIP-Seq_HELA_Human0.99676575
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99454909
87JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99071459
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.98533711
89BCOR_27268052_Chip-Seq_Bcells_Human0.98456857
90SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98248747
91JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98221329
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97752974
93SPI1_23127762_ChIP-Seq_K562_Human0.97019867
94REST_21632747_ChIP-Seq_MESCs_Mouse0.95175595
95ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94004854
96GATA1_22025678_ChIP-Seq_K562_Human0.92763555
97TP53_23651856_ChIP-Seq_MEFs_Mouse0.90953651
98RUNX_20019798_ChIP-Seq_JUKART_Human0.90104350
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89632882
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88487895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001299_abnormal_eye_distance/4.40594580
2MP0001851_eye_inflammation3.11724263
3MP0003436_decreased_susceptibility_to2.76418621
4MP0005083_abnormal_biliary_tract2.50611869
5MP0000569_abnormal_digit_pigmentation2.45353576
6MP0002396_abnormal_hematopoietic_system2.38842891
7MP0000566_synostosis2.37094902
8MP0003890_abnormal_embryonic-extraembry2.21545027
9MP0005174_abnormal_tail_pigmentation2.13670666
10MP0001986_abnormal_taste_sensitivity2.12941443
11MP0001348_abnormal_lacrimal_gland11.0007214
12MP0001984_abnormal_olfaction1.99950965
13MP0005253_abnormal_eye_physiology1.99845059
14MP0001664_abnormal_digestion1.97676611
15MP0010234_abnormal_vibrissa_follicle1.96106125
16MP0008877_abnormal_DNA_methylation1.77573056
17MP0002751_abnormal_autonomic_nervous1.77026213
18MP0004381_abnormal_hair_follicle1.74262119
19MP0006072_abnormal_retinal_apoptosis1.67569756
20MP0004043_abnormal_pH_regulation1.63102381
21MP0005397_hematopoietic_system_phenotyp1.60356650
22MP0001545_abnormal_hematopoietic_system1.60356650
23MP0003763_abnormal_thymus_physiology1.59876584
24MP0002928_abnormal_bile_duct1.53646121
25MP0002092_abnormal_eye_morphology1.48773911
26MP0003045_fibrosis1.47225450
27MP0003172_abnormal_lysosome_physiology1.45448516
28MP0006276_abnormal_autonomic_nervous1.42231452
29MP0005058_abnormal_lysosome_morphology1.39580169
30MP0003075_altered_response_to1.38599070
31MP0005220_abnormal_exocrine_pancreas1.36282112
32MP0003279_aneurysm1.35570037
33MP0009046_muscle_twitch1.33523732
34MP0003183_abnormal_peptide_metabolism1.33503124
35MP0002909_abnormal_adrenal_gland1.31468151
36MP0003879_abnormal_hair_cell1.30567213
37MP0004133_heterotaxia1.21597581
38MP0008057_abnormal_DNA_replication1.17439729
39MP0003828_pulmonary_edema1.15445115
40MP0005166_decreased_susceptibility_to1.15256033
41MP0000538_abnormal_urinary_bladder1.10669370
42MP0003136_yellow_coat_color1.09774011
43MP0005391_vision/eye_phenotype1.08866257
44MP0003091_abnormal_cell_migration1.07648521
45MP0005310_abnormal_salivary_gland1.04088658
46MP0004084_abnormal_cardiac_muscle1.01756385
47MP0008004_abnormal_stomach_pH0.99599655
48MP0005409_darkened_coat_color0.95458396
49MP0001502_abnormal_circadian_rhythm0.93332769
50MP0009384_cardiac_valve_regurgitation0.91858040
51MP0005620_abnormal_muscle_contractility0.87289551
52MP0003656_abnormal_erythrocyte_physiolo0.84623071
53MP0001800_abnormal_humoral_immune0.80696769
54MP0002933_joint_inflammation0.79908681
55MP0008775_abnormal_heart_ventricle0.77365158
56MP0003635_abnormal_synaptic_transmissio0.76402155
57MP0002638_abnormal_pupillary_reflex0.75675844
58MP0002398_abnormal_bone_marrow0.73076992
59MP0001340_abnormal_eyelid_morphology0.72697535
60MP0000470_abnormal_stomach_morphology0.72620197
61MP0008961_abnormal_basal_metabolism0.71094453
62MP0005076_abnormal_cell_differentiation0.70833898
63MP0000703_abnormal_thymus_morphology0.69834386
64MP0000537_abnormal_urethra_morphology0.69148808
65MP0000750_abnormal_muscle_regeneration0.68870309
66MP0004036_abnormal_muscle_relaxation0.68568944
67MP0001756_abnormal_urination0.67082673
68MP0005000_abnormal_immune_tolerance0.67026294
69MP0002067_abnormal_sensory_capabilities0.65780544
70MP0005257_abnormal_intraocular_pressure0.65446173
71MP0005499_abnormal_olfactory_system0.65080829
72MP0005394_taste/olfaction_phenotype0.65080829
73MP0000767_abnormal_smooth_muscle0.64465069
74MP0004808_abnormal_hematopoietic_stem0.62538674
75MP0001835_abnormal_antigen_presentation0.61528295
76MP0001790_abnormal_immune_system0.61063697
77MP0005387_immune_system_phenotype0.61063697
78MP0010155_abnormal_intestine_physiology0.60884587
79MP0002723_abnormal_immune_serum0.59754363
80MP0002420_abnormal_adaptive_immunity0.58691931
81MP0003221_abnormal_cardiomyocyte_apopto0.58232916
82MP0003705_abnormal_hypodermis_morpholog0.57529824
83MP0005551_abnormal_eye_electrophysiolog0.57267984
84MP0005621_abnormal_cell_physiology0.55525249
85MP0001819_abnormal_immune_cell0.55077504
86MP0003866_abnormal_defecation0.53859778
87MP0000026_abnormal_inner_ear0.53801325
88MP0001765_abnormal_ion_homeostasis0.52491922
89MP0002882_abnormal_neuron_morphology0.52338973
90MP0005385_cardiovascular_system_phenoty0.51967776
91MP0001544_abnormal_cardiovascular_syste0.51967776
92MP0000749_muscle_degeneration0.51633064
93MP0003787_abnormal_imprinting0.50319373
94MP0006035_abnormal_mitochondrial_morpho0.49899119
95MP0001188_hyperpigmentation0.49463075
96MP0000343_altered_response_to0.49286297
97MP0000716_abnormal_immune_system0.47867273
98MP0004742_abnormal_vestibular_system0.47789121
99MP0000685_abnormal_immune_system0.46081522
100MP0003329_amyloid_beta_deposits0.45773879

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.69100492
2Abnormality of the intrinsic pathway (HP:0010989)5.85712038
3Rectal prolapse (HP:0002035)4.70107148
4Congenital malformation of the right heart (HP:0011723)4.63022287
5Double outlet right ventricle (HP:0001719)4.63022287
6Abnormality of the columella (HP:0009929)3.86639114
7Anomalous pulmonary venous return (HP:0010772)3.60951654
8Hypoalbuminemia (HP:0003073)3.24857642
9Abnormal albumin level (HP:0012116)3.24857642
10Narrow palate (HP:0000189)3.18191527
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.07220386
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.07220386
13Abnormality of the pulmonary veins (HP:0011718)3.03118924
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.94550438
15Pancreatic fibrosis (HP:0100732)2.92299100
16Abnormality of incisor morphology (HP:0011063)2.88064876
17Chronic hepatic failure (HP:0100626)2.84325450
18Sepsis (HP:0100806)2.79819129
19High anterior hairline (HP:0009890)2.77043337
20Abnormality of the fingertips (HP:0001211)2.76379837
21Neoplasm of the thyroid gland (HP:0100031)2.72372171
22Thin bony cortex (HP:0002753)2.60464141
23Small hand (HP:0200055)2.59158456
24Genetic anticipation (HP:0003743)2.53735800
25Tubulointerstitial nephritis (HP:0001970)2.51740468
26Fetal akinesia sequence (HP:0001989)2.51384350
27Aplastic anemia (HP:0001915)2.47104599
28Intestinal polyposis (HP:0200008)2.43685652
29Abnormal pancreas size (HP:0012094)2.42354675
30Intestinal polyp (HP:0005266)2.34750370
31Hematochezia (HP:0002573)2.28292498
32Cubitus valgus (HP:0002967)2.27324589
33Annular pancreas (HP:0001734)2.25329051
34Prominent nose (HP:0000448)2.24100464
35Congenital stationary night blindness (HP:0007642)2.23693307
36Macular degeneration (HP:0000608)2.23553918
37Clumsiness (HP:0002312)2.20652334
38Agitation (HP:0000713)2.18431450
39Coronal craniosynostosis (HP:0004440)2.15088463
40Abnormality of the corticospinal tract (HP:0002492)2.11153421
41Hypermetropia (HP:0000540)2.10912668
42Adducted thumb (HP:0001181)2.10016423
43Prolonged QT interval (HP:0001657)2.07100999
44Protruding tongue (HP:0010808)2.07052832
45Chromsome breakage (HP:0040012)2.06674493
46Heterotopia (HP:0002282)2.05222513
47Rib fusion (HP:0000902)2.02343669
48Increased number of teeth (HP:0011069)2.00968130
49Sparse lateral eyebrow (HP:0005338)1.98165607
50Hypoplastic iliac wings (HP:0002866)1.97826190
51Severe combined immunodeficiency (HP:0004430)1.97648580
52Deep palmar crease (HP:0006191)1.96349000
53Long eyelashes (HP:0000527)1.94410558
54Gaze-evoked nystagmus (HP:0000640)1.93973645
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92260873
56Conical tooth (HP:0000698)1.91840636
57Lip pit (HP:0100267)1.91738105
58Flat occiput (HP:0005469)1.90546458
59Turricephaly (HP:0000262)1.88896625
60Polydipsia (HP:0001959)1.88279400
61Abnormal drinking behavior (HP:0030082)1.88279400
62Ulnar bowing (HP:0003031)1.88112352
63Short chin (HP:0000331)1.84839876
64Broad face (HP:0000283)1.84292567
65Thyroiditis (HP:0100646)1.83411113
66Abnormality of the incisor (HP:0000676)1.82150487
67Periauricular skin pits (HP:0100277)1.80808675
68Preauricular pit (HP:0004467)1.80808675
69Aortic aneurysm (HP:0004942)1.79475276
70Dyschromatopsia (HP:0007641)1.79247483
71Femoral bowing (HP:0002980)1.78348388
72Abnormality of eosinophils (HP:0001879)1.75912253
73Difficulty running (HP:0009046)1.75762569
74Pustule (HP:0200039)1.74048651
75Self-mutilation (HP:0000742)1.73974679
76Flat face (HP:0012368)1.71845301
77Chin dimple (HP:0010751)1.71517357
78Acute myeloid leukemia (HP:0004808)1.71513029
79Smooth philtrum (HP:0000319)1.71323474
80Aqueductal stenosis (HP:0002410)1.70134052
81Pulmonic stenosis (HP:0001642)1.69999278
82Pseudobulbar signs (HP:0002200)1.69574730
83Frequent falls (HP:0002359)1.68882123
84Hyporeflexia of lower limbs (HP:0002600)1.63740985
85Short palm (HP:0004279)1.61789945
86Aplasia cutis congenita (HP:0001057)1.61253797
87Enlarged epiphyses (HP:0010580)1.60816329
88Dysmetric saccades (HP:0000641)1.58543315
89Decreased circulating renin level (HP:0003351)1.55004011
90Febrile seizures (HP:0002373)1.54331379
91Truncus arteriosus (HP:0001660)1.54092102
92Poikiloderma (HP:0001029)1.53480553
93Spina bifida occulta (HP:0003298)1.53157819
94Abdominal situs inversus (HP:0003363)1.52564628
95Abnormality of abdominal situs (HP:0011620)1.52564628
96Long palpebral fissure (HP:0000637)1.52491384
97Stage 5 chronic kidney disease (HP:0003774)1.52212383
98Nonimmune hydrops fetalis (HP:0001790)1.51954850
99Ectopic kidney (HP:0000086)1.51246398
100Autoimmune thrombocytopenia (HP:0001973)1.51180554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.68581724
2PINK13.60288811
3MAPK152.72365890
4MAP3K132.64714819
5FRK2.45783953
6NEK22.37877718
7PRPF4B2.34139880
8KSR12.33049182
9ICK2.32368624
10BRD42.03248859
11PDK21.91727832
12EEF2K1.80832715
13BCR1.76141051
14SIK21.69300039
15MAPK121.67540787
16WNK41.65855523
17KSR21.63959317
18CAMK1D1.57674771
19MAP3K111.53350696
20PAK31.51414899
21TAOK31.48702414
22CAMK1G1.45740393
23BTK1.41908556
24BLK1.40272303
25MARK31.35081424
26MARK21.30528864
27FGFR21.30052151
28ZAP701.27582850
29EPHB21.27371430
30MAP4K11.26768369
31TYRO31.25204828
32TRIB31.21659312
33MAP2K31.20869935
34MELK1.16935671
35SIK11.13419572
36MTOR1.10203395
37MAP3K11.09754188
38ARAF1.06418000
39FGFR31.05984698
40TNK21.04698255
41MAP3K21.03139162
42AKT31.03036121
43EPHB11.02009343
44MAP3K30.97899082
45FES0.96599009
46WNK10.92105094
47CDC42BPA0.91678684
48PRKCQ0.86624549
49RAF10.84841628
50CAMK40.84076257
51MAP3K70.83907265
52TRPM70.83229961
53CSF1R0.82439065
54TAOK10.82106306
55MAP3K140.81336491
56MAP3K90.81183878
57LATS10.77861103
58ERBB20.77200715
59STK110.76755239
60TYK20.75953047
61NTRK20.74452378
62CSK0.72689309
63DMPK0.72406952
64ITK0.69093488
65KIT0.68025233
66CAMKK10.67402393
67PDGFRB0.66170016
68OBSCN0.65353053
69CDK30.65261914
70HCK0.61654025
71MAPK110.60501059
72IRAK20.59495700
73TAF10.57063262
74ADRBK20.55667037
75HIPK20.55265567
76NLK0.54788817
77LRRK20.54630274
78TEC0.54378916
79NTRK10.53702671
80PRKAA10.53621328
81SGK4940.51714237
82SGK2230.51714237
83PRKAA20.50671356
84PDPK10.50229114
85LCK0.49971265
86GRK60.47671638
87CSNK1G20.46802544
88ERN10.46470893
89SIK30.44477223
90MAPK130.42442603
91PRKCH0.39918341
92RET0.39647115
93AKT10.39134227
94SGK10.38762317
95CAMKK20.38672784
96STK380.38594155
97IRAK10.37154341
98RPS6KC10.36099709
99RPS6KL10.36099709
100PRKD10.35906548

Predicted pathways (KEGG)

RankGene SetZ-score
1Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.36419972
2Lysine degradation_Homo sapiens_hsa003102.32802570
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.97372133
4VEGF signaling pathway_Homo sapiens_hsa043701.83215056
5T cell receptor signaling pathway_Homo sapiens_hsa046601.62140310
6Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59283283
7ErbB signaling pathway_Homo sapiens_hsa040121.57615783
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53939441
9Platelet activation_Homo sapiens_hsa046111.50599447
10Inositol phosphate metabolism_Homo sapiens_hsa005621.46512285
11Osteoclast differentiation_Homo sapiens_hsa043801.45980850
12mTOR signaling pathway_Homo sapiens_hsa041501.41067474
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37626998
14GnRH signaling pathway_Homo sapiens_hsa049121.36921781
15B cell receptor signaling pathway_Homo sapiens_hsa046621.35016190
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34182348
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32868350
18Dorso-ventral axis formation_Homo sapiens_hsa043201.21428314
19MAPK signaling pathway_Homo sapiens_hsa040101.21351006
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21098507
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20122928
22Acute myeloid leukemia_Homo sapiens_hsa052211.19815719
23ABC transporters_Homo sapiens_hsa020101.17478245
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13491991
25Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13053113
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12847110
27FoxO signaling pathway_Homo sapiens_hsa040681.11517214
28Prolactin signaling pathway_Homo sapiens_hsa049171.10610660
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10474944
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08616794
31Chronic myeloid leukemia_Homo sapiens_hsa052201.07162753
32Renal cell carcinoma_Homo sapiens_hsa052111.04669435
33Notch signaling pathway_Homo sapiens_hsa043301.03196394
34Oxytocin signaling pathway_Homo sapiens_hsa049211.02310961
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.02309615
36Type II diabetes mellitus_Homo sapiens_hsa049301.02099205
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95798379
38Sphingolipid signaling pathway_Homo sapiens_hsa040710.94690750
39Vascular smooth muscle contraction_Homo sapiens_hsa042700.94378237
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92924651
41Ovarian steroidogenesis_Homo sapiens_hsa049130.91850257
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91522436
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91339188
44Calcium signaling pathway_Homo sapiens_hsa040200.90864611
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90397931
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.90388284
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90040147
48Colorectal cancer_Homo sapiens_hsa052100.89765371
49Endometrial cancer_Homo sapiens_hsa052130.89617474
50Cholinergic synapse_Homo sapiens_hsa047250.86804807
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84314772
52Choline metabolism in cancer_Homo sapiens_hsa052310.83089959
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82064594
54Estrogen signaling pathway_Homo sapiens_hsa049150.81081706
55Taste transduction_Homo sapiens_hsa047420.78674233
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77546001
57Fatty acid biosynthesis_Homo sapiens_hsa000610.76423740
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76005859
59Rap1 signaling pathway_Homo sapiens_hsa040150.73740005
60Long-term depression_Homo sapiens_hsa047300.73622818
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73075603
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.72455054
63Dilated cardiomyopathy_Homo sapiens_hsa054140.71834110
64Hepatitis B_Homo sapiens_hsa051610.70109673
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68949435
66Glutamatergic synapse_Homo sapiens_hsa047240.68643782
67TNF signaling pathway_Homo sapiens_hsa046680.68339226
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68006395
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67743686
70Morphine addiction_Homo sapiens_hsa050320.66363200
71cAMP signaling pathway_Homo sapiens_hsa040240.65960863
72Salivary secretion_Homo sapiens_hsa049700.65160194
73Long-term potentiation_Homo sapiens_hsa047200.64629898
74Axon guidance_Homo sapiens_hsa043600.63667532
75Melanoma_Homo sapiens_hsa052180.62891229
76Circadian entrainment_Homo sapiens_hsa047130.62804150
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.62606485
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62544352
79Ras signaling pathway_Homo sapiens_hsa040140.62137786
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60459127
81Nicotine addiction_Homo sapiens_hsa050330.60340433
82Insulin resistance_Homo sapiens_hsa049310.60220814
83Hematopoietic cell lineage_Homo sapiens_hsa046400.60083502
84Glucagon signaling pathway_Homo sapiens_hsa049220.60020397
85Non-small cell lung cancer_Homo sapiens_hsa052230.59634387
86Olfactory transduction_Homo sapiens_hsa047400.59482356
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58492012
88Sphingolipid metabolism_Homo sapiens_hsa006000.58429357
89Hepatitis C_Homo sapiens_hsa051600.57292679
90Regulation of autophagy_Homo sapiens_hsa041400.57219664
91Influenza A_Homo sapiens_hsa051640.55379145
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55235223
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.55016096
94Measles_Homo sapiens_hsa051620.54127738
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53739396
96Apoptosis_Homo sapiens_hsa042100.52905012
97Focal adhesion_Homo sapiens_hsa045100.52503216
98Pancreatic cancer_Homo sapiens_hsa052120.51974916
99Oocyte meiosis_Homo sapiens_hsa041140.51797265
100Complement and coagulation cascades_Homo sapiens_hsa046100.49596565

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