ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to misfolded protein (GO:0051788)	9.99595833
2	dendritic spine morphogenesis (GO:0060997)	7.14202996
3	regulation of plasminogen activation (GO:0010755)	6.76524729
4	superoxide anion generation (GO:0042554)	6.52510657
5	ncRNA 3-end processing (GO:0043628)	5.33312281
6	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	5.19185864
7	negative regulation of translation, ncRNA-mediated (GO:0040033)	5.19185864
8	regulation of translation, ncRNA-mediated (GO:0045974)	5.19185864
9	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.97709355
10	protein autoprocessing (GO:0016540)	4.80880192
11	cytoplasmic mRNA processing body assembly (GO:0033962)	4.70140234
12	retinal rod cell development (GO:0046548)	4.52857516
13	regulation of fibrinolysis (GO:0051917)	4.09707586
14	interferon-gamma production (GO:0032609)	3.90076828
15	dendritic spine organization (GO:0097061)	3.89859817
16	neutrophil mediated immunity (GO:0002446)	3.79779345
17	negative regulation of Rho protein signal transduction (GO:0035024)	3.73669382
18	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.68148326
19	positive regulation of granulocyte differentiation (GO:0030854)	3.67542004
20	regulation of proton transport (GO:0010155)	3.60778524
21	negative regulation of erythrocyte differentiation (GO:0045647)	3.53676526
22	nerve development (GO:0021675)	3.39111399
23	histone H3-K36 demethylation (GO:0070544)	3.38977602
24	negative regulation of cell cycle arrest (GO:0071157)	3.36036767
25	photoreceptor cell maintenance (GO:0045494)	3.31683001
26	cell migration in hindbrain (GO:0021535)	3.30446342
27	venous blood vessel morphogenesis (GO:0048845)	3.28244549
28	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.27141440
29	fibrinolysis (GO:0042730)	3.25900917
30	histone lysine methylation (GO:0034968)	3.25026641
31	N-terminal protein amino acid acetylation (GO:0006474)	3.24370568
32	regulation of ARF GTPase activity (GO:0032312)	3.24315450
33	negative regulation of glycoprotein biosynthetic process (GO:0010561)	3.22694613
34	mannose metabolic process (GO:0006013)	3.20050773
35	positive regulation of protein kinase C signaling (GO:0090037)	3.03095317
36	myeloid leukocyte mediated immunity (GO:0002444)	2.99714676
37	positive regulation of catecholamine secretion (GO:0033605)	2.94100433
38	activated T cell proliferation (GO:0050798)	2.93879506
39	regulation of granulocyte differentiation (GO:0030852)	2.92478043
40	regulation of respiratory system process (GO:0044065)	2.90526125
41	urogenital system development (GO:0001655)	2.88092110
42	cranial nerve morphogenesis (GO:0021602)	2.86635082
43	dendrite development (GO:0016358)	2.85243531
44	ventricular system development (GO:0021591)	2.84050562
45	endoderm formation (GO:0001706)	2.83387254
46	TOR signaling (GO:0031929)	2.83125082
47	relaxation of smooth muscle (GO:0044557)	2.82312880
48	histone H3-K4 methylation (GO:0051568)	2.78756373
49	histone H3-K4 trimethylation (GO:0080182)	2.76406648
50	phospholipid dephosphorylation (GO:0046839)	2.74375131
51	superoxide metabolic process (GO:0006801)	2.73769954
52	post-embryonic morphogenesis (GO:0009886)	2.62640683
53	histone H3-K9 modification (GO:0061647)	2.62559413
54	dopaminergic neuron differentiation (GO:0071542)	2.60310091
55	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.60015097
56	positive regulation of blood coagulation (GO:0030194)	2.59173493
57	positive regulation of hemostasis (GO:1900048)	2.59173493
58	cellular extravasation (GO:0045123)	2.58367996
59	endothelial cell proliferation (GO:0001935)	2.54771577
60	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	2.52828399
61	lipid phosphorylation (GO:0046834)	2.51866968
62	regulation of MHC class I biosynthetic process (GO:0045343)	2.51022395
63	corticosteroid receptor signaling pathway (GO:0031958)	2.50651880
64	snRNA transcription (GO:0009301)	2.50291683
65	sex determination (GO:0007530)	2.45267557
66	phosphatidylinositol dephosphorylation (GO:0046856)	2.43634284
67	phosphatidylinositol 3-kinase signaling (GO:0014065)	2.42847772
68	response to muramyl dipeptide (GO:0032495)	2.42424852
69	phosphatidylinositol phosphorylation (GO:0046854)	2.42424221
70	regulation of respiratory gaseous exchange (GO:0043576)	2.42358773
71	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.40964369
72	positive regulation of CREB transcription factor activity (GO:0032793)	2.40676977
73	negative regulation of Ras protein signal transduction (GO:0046580)	2.40673291
74	prepulse inhibition (GO:0060134)	2.40626889
75	positive regulation of coagulation (GO:0050820)	2.40332766
76	lens fiber cell differentiation (GO:0070306)	2.39339862
77	hydrogen peroxide biosynthetic process (GO:0050665)	2.38975608
78	Rap protein signal transduction (GO:0032486)	2.38539827
79	histone H3 deacetylation (GO:0070932)	2.38454751
80	T cell differentiation involved in immune response (GO:0002292)	2.37679563
81	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.37679563
82	alpha-beta T cell activation involved in immune response (GO:0002287)	2.37679563
83	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.37400172
84	phospholipid scrambling (GO:0017121)	2.36217624
85	blood coagulation, intrinsic pathway (GO:0007597)	2.35609330
86	regulation of NFAT protein import into nucleus (GO:0051532)	2.33833277
87	cerebellar Purkinje cell differentiation (GO:0021702)	2.33774992
88	negative regulation of small GTPase mediated signal transduction (GO:0051058)	2.31816253
89	face development (GO:0060324)	2.28967203
90	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.26062584
91	positive regulation of acute inflammatory response (GO:0002675)	2.24925207
92	regulation of autophagic vacuole assembly (GO:2000785)	2.24293971
93	cytokine secretion (GO:0050663)	2.23143294
94	embryonic viscerocranium morphogenesis (GO:0048703)	2.22624913
95	neural crest cell migration (GO:0001755)	2.22231996
96	olfactory bulb development (GO:0021772)	2.20130879
97	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.19423052
98	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.19320875
99	granulocyte activation (GO:0036230)	2.15563689
100	negative regulation of catenin import into nucleus (GO:0035414)	2.13555571

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	3.29978974
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.27638714
3	VDR_21846776_ChIP-Seq_THP-1_Human	3.10415355
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.96487747
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.72268587
6	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.64719547
7	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.55258655
8	SCL_19346495_ChIP-Seq_HPC-7_Human	2.50004485
9	KDM2B_26808549_Chip-Seq_DND41_Human	2.48631962
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.46440575
11	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.43723151
12	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.40066433
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.32083895
14	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.08590973
15	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.06320272
16	MYC_22102868_ChIP-Seq_BL_Human	2.02005356
17	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.98615580
18	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.94527900
19	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.93142211
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.91428797
21	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.90720394
22	TCF7_22412390_ChIP-Seq_EML_Mouse	1.90265816
23	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.87404938
24	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.86715367
25	AR_21572438_ChIP-Seq_LNCaP_Human	1.85584746
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.85058700
27	MAF_26560356_Chip-Seq_TH2_Human	1.73322117
28	LXR_22292898_ChIP-Seq_THP-1_Human	1.71806625
29	KDM2B_26808549_Chip-Seq_K562_Human	1.71389754
30	MAF_26560356_Chip-Seq_TH1_Human	1.65564239
31	VDR_24763502_ChIP-Seq_THP-1_Human	1.61302013
32	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.59756923
33	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.57382206
34	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.55935961
35	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.51006713
36	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.50967680
37	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.38305492
38	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.38038207
39	CTCF_27219007_Chip-Seq_Bcells_Human	1.37691521
40	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.36618694
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35216029
42	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.33617973
43	P68_20966046_ChIP-Seq_HELA_Human	1.33067905
44	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30542104
45	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.30227481
46	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.29429651
47	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.26851811
48	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.26199014
49	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.25565609
50	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.24676684
51	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.23000811
52	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.22906229
53	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.21929644
54	RACK7_27058665_Chip-Seq_MCF-7_Human	1.21448484
55	CREB1_26743006_Chip-Seq_LNCaP_Human	1.20287724
56	RXR_22108803_ChIP-Seq_LS180_Human	1.18322876
57	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18120568
58	SMC4_20622854_ChIP-Seq_HELA_Human	1.16239022
59	UTX_26944678_Chip-Seq_JUKART_Human	1.14811230
60	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.14303181
61	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13771352
62	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.13583604
63	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.13583604
64	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.13393065
65	ERA_21632823_ChIP-Seq_H3396_Human	1.13146452
66	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.13047565
67	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.12181864
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11130531
69	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.10770737
70	TP63_22573176_ChIP-Seq_HFKS_Human	1.10611070
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09462113
72	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.08502658
73	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.08397989
74	E2F1_20622854_ChIP-Seq_HELA_Human	1.07601430
75	GATA2_19941826_ChIP-Seq_K562_Human	1.06025991
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05812314
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.04411836
78	TFEB_21752829_ChIP-Seq_HELA_Human	1.01593758
79	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.01243944
80	OCT4_19829295_ChIP-Seq_ESCs_Human	1.01230959
81	AHR_22903824_ChIP-Seq_MCF-7_Human	1.01061894
82	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.00789972
83	GATA1_19941826_ChIP-Seq_K562_Human	1.00672828
84	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99867588
85	PHF8_20622854_ChIP-Seq_HELA_Human	0.99676575
86	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.99454909
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.99071459
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.98533711
89	BCOR_27268052_Chip-Seq_Bcells_Human	0.98456857
90	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.98248747
91	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98221329
92	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.97752974
93	SPI1_23127762_ChIP-Seq_K562_Human	0.97019867
94	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95175595
95	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.94004854
96	GATA1_22025678_ChIP-Seq_K562_Human	0.92763555
97	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.90953651
98	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90104350
99	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.89632882
100	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.88487895

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001299_abnormal_eye_distance/	4.40594580
2	MP0001851_eye_inflammation	3.11724263
3	MP0003436_decreased_susceptibility_to	2.76418621
4	MP0005083_abnormal_biliary_tract	2.50611869
5	MP0000569_abnormal_digit_pigmentation	2.45353576
6	MP0002396_abnormal_hematopoietic_system	2.38842891
7	MP0000566_synostosis	2.37094902
8	MP0003890_abnormal_embryonic-extraembry	2.21545027
9	MP0005174_abnormal_tail_pigmentation	2.13670666
10	MP0001986_abnormal_taste_sensitivity	2.12941443
11	MP0001348_abnormal_lacrimal_gland	11.0007214
12	MP0001984_abnormal_olfaction	1.99950965
13	MP0005253_abnormal_eye_physiology	1.99845059
14	MP0001664_abnormal_digestion	1.97676611
15	MP0010234_abnormal_vibrissa_follicle	1.96106125
16	MP0008877_abnormal_DNA_methylation	1.77573056
17	MP0002751_abnormal_autonomic_nervous	1.77026213
18	MP0004381_abnormal_hair_follicle	1.74262119
19	MP0006072_abnormal_retinal_apoptosis	1.67569756
20	MP0004043_abnormal_pH_regulation	1.63102381
21	MP0001545_abnormal_hematopoietic_system	1.60356650
22	MP0005397_hematopoietic_system_phenotyp	1.60356650
23	MP0003763_abnormal_thymus_physiology	1.59876584
24	MP0002928_abnormal_bile_duct	1.53646121
25	MP0002092_abnormal_eye_morphology	1.48773911
26	MP0003045_fibrosis	1.47225450
27	MP0003172_abnormal_lysosome_physiology	1.45448516
28	MP0006276_abnormal_autonomic_nervous	1.42231452
29	MP0005058_abnormal_lysosome_morphology	1.39580169
30	MP0003075_altered_response_to	1.38599070
31	MP0005220_abnormal_exocrine_pancreas	1.36282112
32	MP0003279_aneurysm	1.35570037
33	MP0009046_muscle_twitch	1.33523732
34	MP0003183_abnormal_peptide_metabolism	1.33503124
35	MP0002909_abnormal_adrenal_gland	1.31468151
36	MP0003879_abnormal_hair_cell	1.30567213
37	MP0004133_heterotaxia	1.21597581
38	MP0008057_abnormal_DNA_replication	1.17439729
39	MP0003828_pulmonary_edema	1.15445115
40	MP0005166_decreased_susceptibility_to	1.15256033
41	MP0000538_abnormal_urinary_bladder	1.10669370
42	MP0003136_yellow_coat_color	1.09774011
43	MP0005391_vision/eye_phenotype	1.08866257
44	MP0003091_abnormal_cell_migration	1.07648521
45	MP0005310_abnormal_salivary_gland	1.04088658
46	MP0004084_abnormal_cardiac_muscle	1.01756385
47	MP0008004_abnormal_stomach_pH	0.99599655
48	MP0005409_darkened_coat_color	0.95458396
49	MP0001502_abnormal_circadian_rhythm	0.93332769
50	MP0009384_cardiac_valve_regurgitation	0.91858040
51	MP0005620_abnormal_muscle_contractility	0.87289551
52	MP0003656_abnormal_erythrocyte_physiolo	0.84623071
53	MP0001800_abnormal_humoral_immune	0.80696769
54	MP0002933_joint_inflammation	0.79908681
55	MP0008775_abnormal_heart_ventricle	0.77365158
56	MP0003635_abnormal_synaptic_transmissio	0.76402155
57	MP0002638_abnormal_pupillary_reflex	0.75675844
58	MP0002398_abnormal_bone_marrow	0.73076992
59	MP0001340_abnormal_eyelid_morphology	0.72697535
60	MP0000470_abnormal_stomach_morphology	0.72620197
61	MP0008961_abnormal_basal_metabolism	0.71094453
62	MP0005076_abnormal_cell_differentiation	0.70833898
63	MP0000703_abnormal_thymus_morphology	0.69834386
64	MP0000537_abnormal_urethra_morphology	0.69148808
65	MP0000750_abnormal_muscle_regeneration	0.68870309
66	MP0004036_abnormal_muscle_relaxation	0.68568944
67	MP0001756_abnormal_urination	0.67082673
68	MP0005000_abnormal_immune_tolerance	0.67026294
69	MP0002067_abnormal_sensory_capabilities	0.65780544
70	MP0005257_abnormal_intraocular_pressure	0.65446173
71	MP0005394_taste/olfaction_phenotype	0.65080829
72	MP0005499_abnormal_olfactory_system	0.65080829
73	MP0000767_abnormal_smooth_muscle	0.64465069
74	MP0004808_abnormal_hematopoietic_stem	0.62538674
75	MP0001835_abnormal_antigen_presentation	0.61528295
76	MP0001790_abnormal_immune_system	0.61063697
77	MP0005387_immune_system_phenotype	0.61063697
78	MP0010155_abnormal_intestine_physiology	0.60884587
79	MP0002723_abnormal_immune_serum	0.59754363
80	MP0002420_abnormal_adaptive_immunity	0.58691931
81	MP0003221_abnormal_cardiomyocyte_apopto	0.58232916
82	MP0003705_abnormal_hypodermis_morpholog	0.57529824
83	MP0005551_abnormal_eye_electrophysiolog	0.57267984
84	MP0005621_abnormal_cell_physiology	0.55525249
85	MP0001819_abnormal_immune_cell	0.55077504
86	MP0003866_abnormal_defecation	0.53859778
87	MP0000026_abnormal_inner_ear	0.53801325
88	MP0001765_abnormal_ion_homeostasis	0.52491922
89	MP0002882_abnormal_neuron_morphology	0.52338973
90	MP0001544_abnormal_cardiovascular_syste	0.51967776
91	MP0005385_cardiovascular_system_phenoty	0.51967776
92	MP0000749_muscle_degeneration	0.51633064
93	MP0003787_abnormal_imprinting	0.50319373
94	MP0006035_abnormal_mitochondrial_morpho	0.49899119
95	MP0001188_hyperpigmentation	0.49463075
96	MP0000343_altered_response_to	0.49286297
97	MP0000716_abnormal_immune_system	0.47867273
98	MP0004742_abnormal_vestibular_system	0.47789121
99	MP0000685_abnormal_immune_system	0.46081522
100	MP0003329_amyloid_beta_deposits	0.45773879

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	6.69100492
2	Abnormality of the intrinsic pathway (HP:0010989)	5.85712038
3	Rectal prolapse (HP:0002035)	4.70107148
4	Congenital malformation of the right heart (HP:0011723)	4.63022287
5	Double outlet right ventricle (HP:0001719)	4.63022287
6	Abnormality of the columella (HP:0009929)	3.86639114
7	Anomalous pulmonary venous return (HP:0010772)	3.60951654
8	Hypoalbuminemia (HP:0003073)	3.24857642
9	Abnormal albumin level (HP:0012116)	3.24857642
10	Narrow palate (HP:0000189)	3.18191527
11	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.07220386
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.07220386
13	Abnormality of the pulmonary veins (HP:0011718)	3.03118924
14	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.94550438
15	Pancreatic fibrosis (HP:0100732)	2.92299100
16	Abnormality of incisor morphology (HP:0011063)	2.88064876
17	Chronic hepatic failure (HP:0100626)	2.84325450
18	Sepsis (HP:0100806)	2.79819129
19	High anterior hairline (HP:0009890)	2.77043337
20	Abnormality of the fingertips (HP:0001211)	2.76379837
21	Neoplasm of the thyroid gland (HP:0100031)	2.72372171
22	Thin bony cortex (HP:0002753)	2.60464141
23	Small hand (HP:0200055)	2.59158456
24	Genetic anticipation (HP:0003743)	2.53735800
25	Tubulointerstitial nephritis (HP:0001970)	2.51740468
26	Fetal akinesia sequence (HP:0001989)	2.51384350
27	Aplastic anemia (HP:0001915)	2.47104599
28	Intestinal polyposis (HP:0200008)	2.43685652
29	Abnormal pancreas size (HP:0012094)	2.42354675
30	Intestinal polyp (HP:0005266)	2.34750370
31	Hematochezia (HP:0002573)	2.28292498
32	Cubitus valgus (HP:0002967)	2.27324589
33	Annular pancreas (HP:0001734)	2.25329051
34	Prominent nose (HP:0000448)	2.24100464
35	Congenital stationary night blindness (HP:0007642)	2.23693307
36	Macular degeneration (HP:0000608)	2.23553918
37	Clumsiness (HP:0002312)	2.20652334
38	Agitation (HP:0000713)	2.18431450
39	Coronal craniosynostosis (HP:0004440)	2.15088463
40	Abnormality of the corticospinal tract (HP:0002492)	2.11153421
41	Hypermetropia (HP:0000540)	2.10912668
42	Adducted thumb (HP:0001181)	2.10016423
43	Prolonged QT interval (HP:0001657)	2.07100999
44	Protruding tongue (HP:0010808)	2.07052832
45	Chromsome breakage (HP:0040012)	2.06674493
46	Heterotopia (HP:0002282)	2.05222513
47	Rib fusion (HP:0000902)	2.02343669
48	Increased number of teeth (HP:0011069)	2.00968130
49	Sparse lateral eyebrow (HP:0005338)	1.98165607
50	Hypoplastic iliac wings (HP:0002866)	1.97826190
51	Severe combined immunodeficiency (HP:0004430)	1.97648580
52	Deep palmar crease (HP:0006191)	1.96349000
53	Long eyelashes (HP:0000527)	1.94410558
54	Gaze-evoked nystagmus (HP:0000640)	1.93973645
55	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.92260873
56	Conical tooth (HP:0000698)	1.91840636
57	Lip pit (HP:0100267)	1.91738105
58	Flat occiput (HP:0005469)	1.90546458
59	Turricephaly (HP:0000262)	1.88896625
60	Polydipsia (HP:0001959)	1.88279400
61	Abnormal drinking behavior (HP:0030082)	1.88279400
62	Ulnar bowing (HP:0003031)	1.88112352
63	Short chin (HP:0000331)	1.84839876
64	Broad face (HP:0000283)	1.84292567
65	Thyroiditis (HP:0100646)	1.83411113
66	Abnormality of the incisor (HP:0000676)	1.82150487
67	Preauricular pit (HP:0004467)	1.80808675
68	Periauricular skin pits (HP:0100277)	1.80808675
69	Aortic aneurysm (HP:0004942)	1.79475276
70	Dyschromatopsia (HP:0007641)	1.79247483
71	Femoral bowing (HP:0002980)	1.78348388
72	Abnormality of eosinophils (HP:0001879)	1.75912253
73	Difficulty running (HP:0009046)	1.75762569
74	Pustule (HP:0200039)	1.74048651
75	Self-mutilation (HP:0000742)	1.73974679
76	Flat face (HP:0012368)	1.71845301
77	Chin dimple (HP:0010751)	1.71517357
78	Acute myeloid leukemia (HP:0004808)	1.71513029
79	Smooth philtrum (HP:0000319)	1.71323474
80	Aqueductal stenosis (HP:0002410)	1.70134052
81	Pulmonic stenosis (HP:0001642)	1.69999278
82	Pseudobulbar signs (HP:0002200)	1.69574730
83	Frequent falls (HP:0002359)	1.68882123
84	Hyporeflexia of lower limbs (HP:0002600)	1.63740985
85	Short palm (HP:0004279)	1.61789945
86	Aplasia cutis congenita (HP:0001057)	1.61253797
87	Enlarged epiphyses (HP:0010580)	1.60816329
88	Dysmetric saccades (HP:0000641)	1.58543315
89	Decreased circulating renin level (HP:0003351)	1.55004011
90	Febrile seizures (HP:0002373)	1.54331379
91	Truncus arteriosus (HP:0001660)	1.54092102
92	Poikiloderma (HP:0001029)	1.53480553
93	Spina bifida occulta (HP:0003298)	1.53157819
94	Abdominal situs inversus (HP:0003363)	1.52564628
95	Abnormality of abdominal situs (HP:0011620)	1.52564628
96	Long palpebral fissure (HP:0000637)	1.52491384
97	Stage 5 chronic kidney disease (HP:0003774)	1.52212383
98	Nonimmune hydrops fetalis (HP:0001790)	1.51954850
99	Ectopic kidney (HP:0000086)	1.51246398
100	Autoimmune thrombocytopenia (HP:0001973)	1.51180554

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK12	3.68581724
2	PINK1	3.60288811
3	MAPK15	2.72365890
4	MAP3K13	2.64714819
5	FRK	2.45783953
6	NEK2	2.37877718
7	PRPF4B	2.34139880
8	KSR1	2.33049182
9	ICK	2.32368624
10	BRD4	2.03248859
11	PDK2	1.91727832
12	EEF2K	1.80832715
13	BCR	1.76141051
14	SIK2	1.69300039
15	MAPK12	1.67540787
16	WNK4	1.65855523
17	KSR2	1.63959317
18	CAMK1D	1.57674771
19	MAP3K11	1.53350696
20	PAK3	1.51414899
21	TAOK3	1.48702414
22	CAMK1G	1.45740393
23	BTK	1.41908556
24	BLK	1.40272303
25	MARK3	1.35081424
26	MARK2	1.30528864
27	FGFR2	1.30052151
28	ZAP70	1.27582850
29	EPHB2	1.27371430
30	MAP4K1	1.26768369
31	TYRO3	1.25204828
32	TRIB3	1.21659312
33	MAP2K3	1.20869935
34	MELK	1.16935671
35	SIK1	1.13419572
36	MTOR	1.10203395
37	MAP3K1	1.09754188
38	ARAF	1.06418000
39	FGFR3	1.05984698
40	TNK2	1.04698255
41	MAP3K2	1.03139162
42	AKT3	1.03036121
43	EPHB1	1.02009343
44	MAP3K3	0.97899082
45	FES	0.96599009
46	WNK1	0.92105094
47	CDC42BPA	0.91678684
48	PRKCQ	0.86624549
49	RAF1	0.84841628
50	CAMK4	0.84076257
51	MAP3K7	0.83907265
52	TRPM7	0.83229961
53	CSF1R	0.82439065
54	TAOK1	0.82106306
55	MAP3K14	0.81336491
56	MAP3K9	0.81183878
57	LATS1	0.77861103
58	ERBB2	0.77200715
59	STK11	0.76755239
60	TYK2	0.75953047
61	NTRK2	0.74452378
62	CSK	0.72689309
63	DMPK	0.72406952
64	ITK	0.69093488
65	KIT	0.68025233
66	CAMKK1	0.67402393
67	PDGFRB	0.66170016
68	OBSCN	0.65353053
69	CDK3	0.65261914
70	HCK	0.61654025
71	MAPK11	0.60501059
72	IRAK2	0.59495700
73	TAF1	0.57063262
74	ADRBK2	0.55667037
75	HIPK2	0.55265567
76	NLK	0.54788817
77	LRRK2	0.54630274
78	TEC	0.54378916
79	NTRK1	0.53702671
80	PRKAA1	0.53621328
81	SGK494	0.51714237
82	SGK223	0.51714237
83	PRKAA2	0.50671356
84	PDPK1	0.50229114
85	LCK	0.49971265
86	GRK6	0.47671638
87	CSNK1G2	0.46802544
88	ERN1	0.46470893
89	SIK3	0.44477223
90	MAPK13	0.42442603
91	PRKCH	0.39918341
92	RET	0.39647115
93	AKT1	0.39134227
94	SGK1	0.38762317
95	CAMKK2	0.38672784
96	STK38	0.38594155
97	IRAK1	0.37154341
98	RPS6KL1	0.36099709
99	RPS6KC1	0.36099709
100	PRKD1	0.35906548

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	2.36419972
2	Lysine degradation_Homo sapiens_hsa00310	2.32802570
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.97372133
4	VEGF signaling pathway_Homo sapiens_hsa04370	1.83215056
5	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.62140310
6	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.59283283
7	ErbB signaling pathway_Homo sapiens_hsa04012	1.57615783
8	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.53939441
9	Platelet activation_Homo sapiens_hsa04611	1.50599447
10	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.46512285
11	Osteoclast differentiation_Homo sapiens_hsa04380	1.45980850
12	mTOR signaling pathway_Homo sapiens_hsa04150	1.41067474
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.37626998
14	GnRH signaling pathway_Homo sapiens_hsa04912	1.36921781
15	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.35016190
16	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.34182348
17	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.32868350
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.21428314
19	MAPK signaling pathway_Homo sapiens_hsa04010	1.21351006
20	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.21098507
21	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.20122928
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.19815719
23	ABC transporters_Homo sapiens_hsa02010	1.17478245
24	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.13491991
25	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.13053113
26	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.12847110
27	FoxO signaling pathway_Homo sapiens_hsa04068	1.11517214
28	Prolactin signaling pathway_Homo sapiens_hsa04917	1.10610660
29	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.10474944
30	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.08616794
31	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.07162753
32	Renal cell carcinoma_Homo sapiens_hsa05211	1.04669435
33	Notch signaling pathway_Homo sapiens_hsa04330	1.03196394
34	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.02310961
35	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.02309615
36	Type II diabetes mellitus_Homo sapiens_hsa04930	1.02099205
37	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.95798379
38	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.94690750
39	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.94378237
40	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.92924651
41	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91850257
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91522436
43	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.91339188
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.90864611
45	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.90397931
46	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.90388284
47	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.90040147
48	Colorectal cancer_Homo sapiens_hsa05210	0.89765371
49	Endometrial cancer_Homo sapiens_hsa05213	0.89617474
50	Cholinergic synapse_Homo sapiens_hsa04725	0.86804807
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84314772
52	Choline metabolism in cancer_Homo sapiens_hsa05231	0.83089959
53	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.82064594
54	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81081706
55	Taste transduction_Homo sapiens_hsa04742	0.78674233
56	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.77546001
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.76423740
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.76005859
59	Rap1 signaling pathway_Homo sapiens_hsa04015	0.73740005
60	Long-term depression_Homo sapiens_hsa04730	0.73622818
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73075603
62	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.72455054
63	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.71834110
64	Hepatitis B_Homo sapiens_hsa05161	0.70109673
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.68949435
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.68643782
67	TNF signaling pathway_Homo sapiens_hsa04668	0.68339226
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68006395
69	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.67743686
70	Morphine addiction_Homo sapiens_hsa05032	0.66363200
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.65960863
72	Salivary secretion_Homo sapiens_hsa04970	0.65160194
73	Long-term potentiation_Homo sapiens_hsa04720	0.64629898
74	Axon guidance_Homo sapiens_hsa04360	0.63667532
75	Melanoma_Homo sapiens_hsa05218	0.62891229
76	Circadian entrainment_Homo sapiens_hsa04713	0.62804150
77	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.62606485
78	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.62544352
79	Ras signaling pathway_Homo sapiens_hsa04014	0.62137786
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.60459127
81	Nicotine addiction_Homo sapiens_hsa05033	0.60340433
82	Insulin resistance_Homo sapiens_hsa04931	0.60220814
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60083502
84	Glucagon signaling pathway_Homo sapiens_hsa04922	0.60020397
85	Non-small cell lung cancer_Homo sapiens_hsa05223	0.59634387
86	Olfactory transduction_Homo sapiens_hsa04740	0.59482356
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58492012
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.58429357
89	Hepatitis C_Homo sapiens_hsa05160	0.57292679
90	Regulation of autophagy_Homo sapiens_hsa04140	0.57219664
91	Influenza A_Homo sapiens_hsa05164	0.55379145
92	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.55235223
93	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.55016096
94	Measles_Homo sapiens_hsa05162	0.54127738
95	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.53739396
96	Apoptosis_Homo sapiens_hsa04210	0.52905012
97	Focal adhesion_Homo sapiens_hsa04510	0.52503216
98	Pancreatic cancer_Homo sapiens_hsa05212	0.51974916
99	Oocyte meiosis_Homo sapiens_hsa04114	0.51797265
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.49596565

NUTM2E

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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