NUTM2F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of inclusion body assembly (GO:0090084)7.64193385
2auditory behavior (GO:0031223)7.34469946
3neurotransmitter-gated ion channel clustering (GO:0072578)6.40391866
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.39539196
5cilium or flagellum-dependent cell motility (GO:0001539)6.36003387
6mechanosensory behavior (GO:0007638)5.56974252
7response to auditory stimulus (GO:0010996)4.98600248
8negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.97624742
9positive regulation of growth hormone secretion (GO:0060124)4.89628726
10leukocyte tethering or rolling (GO:0050901)4.82515775
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56089121
12cilium movement (GO:0003341)4.55234131
13retinal cone cell development (GO:0046549)4.52640285
14behavioral response to nicotine (GO:0035095)4.43403666
15epithelial cilium movement (GO:0003351)4.38141202
16transcytosis (GO:0045056)4.18989455
17regulation of inclusion body assembly (GO:0090083)4.13833813
18regulation of synapse structural plasticity (GO:0051823)4.13532018
19dendritic spine morphogenesis (GO:0060997)4.13495495
20retinal rod cell development (GO:0046548)4.12547965
21kidney morphogenesis (GO:0060993)4.11207443
22vocalization behavior (GO:0071625)4.04063504
23lymphangiogenesis (GO:0001946)4.02422025
24heart trabecula morphogenesis (GO:0061384)4.01603746
25negative regulation of actin filament bundle assembly (GO:0032232)4.01359323
26cell morphogenesis involved in neuron differentiation (GO:0048667)3.82017560
27heme transport (GO:0015886)3.81217780
28blood vessel maturation (GO:0001955)3.76689185
29protein localization to synapse (GO:0035418)3.73068414
30L-ascorbic acid metabolic process (GO:0019852)3.70207967
31motile cilium assembly (GO:0044458)3.63672357
32neuron remodeling (GO:0016322)3.58638649
33mitotic cell cycle arrest (GO:0071850)3.57074610
34nephron epithelium morphogenesis (GO:0072088)3.55746267
35nephron tubule morphogenesis (GO:0072078)3.55746267
36neuronal stem cell maintenance (GO:0097150)3.54561343
37regulation of glutamate receptor signaling pathway (GO:1900449)3.46393808
38negative regulation of blood vessel endothelial cell migration (GO:0043537)3.45184816
39leukotriene biosynthetic process (GO:0019370)3.43860227
40axoneme assembly (GO:0035082)3.42725299
41mRNA transcription from RNA polymerase II promoter (GO:0042789)3.42372980
42regulation of establishment or maintenance of cell polarity (GO:0032878)3.41867697
43embryonic heart tube development (GO:0035050)3.41856962
44leukocyte migration involved in inflammatory response (GO:0002523)3.41092919
45endoderm formation (GO:0001706)3.39016539
46brain morphogenesis (GO:0048854)3.38355401
47neuron maturation (GO:0042551)3.28908904
48cellular response to exogenous dsRNA (GO:0071360)3.26041006
49positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25324018
50regulation of growth hormone secretion (GO:0060123)3.24769003
51notochord development (GO:0030903)3.23936942
52positive regulation of potassium ion transmembrane transport (GO:1901381)3.18840530
53endothelial cell differentiation (GO:0045446)3.17114537
54membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.16759897
55positive regulation of Rap GTPase activity (GO:0032854)3.15954291
56endothelial cell chemotaxis (GO:0035767)3.10565422
57regulation of endothelial cell differentiation (GO:0045601)3.07648375
58regulation of dopamine secretion (GO:0014059)3.07277807
59primary amino compound metabolic process (GO:1901160)2.98707671
60regulation of establishment of cell polarity (GO:2000114)2.95857878
61axonemal dynein complex assembly (GO:0070286)2.95496497
62iron coordination entity transport (GO:1901678)2.95419098
63negative regulation of oligodendrocyte differentiation (GO:0048715)2.95108881
64trabecula morphogenesis (GO:0061383)2.88910933
65cysteine metabolic process (GO:0006534)2.88228567
66water-soluble vitamin biosynthetic process (GO:0042364)2.86787548
67growth hormone secretion (GO:0030252)2.86245112
68phenol-containing compound catabolic process (GO:0019336)2.86191217
69transmission of nerve impulse (GO:0019226)2.85414899
70ventricular trabecula myocardium morphogenesis (GO:0003222)2.85159338
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83825637
72photoreceptor cell maintenance (GO:0045494)2.82984681
73positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.79668771
74cardiac septum development (GO:0003279)2.77581633
75regulation of timing of cell differentiation (GO:0048505)2.74935605
76regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74192975
77inactivation of MAPK activity (GO:0000188)2.73846549
78membrane repolarization during action potential (GO:0086011)2.72657296
79neuronal action potential (GO:0019228)2.70515660
80chaperone-mediated protein complex assembly (GO:0051131)2.70033225
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.68986117
82regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.67769141
83positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.67372485
84renal tubule morphogenesis (GO:0061333)2.67269397
85protein refolding (GO:0042026)2.66851990
86regulation of Rap GTPase activity (GO:0032317)2.65861007
87dopamine biosynthetic process (GO:0042416)2.64409416
88regulation of secondary heart field cardioblast proliferation (GO:0003266)2.63314439
89regulation of cardioblast proliferation (GO:0003264)2.63314439
90serotonin metabolic process (GO:0042428)2.61913386
91ventricular septum development (GO:0003281)2.60595094
92alanine transport (GO:0032328)2.56759671
93microglial cell activation (GO:0001774)2.56687343
94radial glial cell differentiation (GO:0060019)2.56004892
95negative regulation of endothelial cell migration (GO:0010596)2.55780930
96negative regulation of neurotransmitter transport (GO:0051589)2.55224298
97snRNA processing (GO:0016180)2.52287270
98positive regulation of CREB transcription factor activity (GO:0032793)2.51377933
99forebrain neuron differentiation (GO:0021879)2.50854365
100mRNA transcription (GO:0009299)2.49922290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.18669075
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.82411842
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60078099
4EZH2_22144423_ChIP-Seq_EOC_Human3.54194443
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.06306157
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83809450
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78085840
8GBX2_23144817_ChIP-Seq_PC3_Human2.45935785
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18709928
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15877788
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.07181462
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04184603
13AR_21572438_ChIP-Seq_LNCaP_Human2.00720643
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.99309275
15DROSHA_22980978_ChIP-Seq_HELA_Human1.97941593
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95781860
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.88369068
18VDR_22108803_ChIP-Seq_LS180_Human1.87851674
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82749532
20ZNF274_21170338_ChIP-Seq_K562_Hela1.69760976
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69529787
22TP53_16413492_ChIP-PET_HCT116_Human1.68913570
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.65307968
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.59731165
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58391101
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55122002
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55122002
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54908336
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52270644
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50964967
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48719545
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43882765
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43120721
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43071574
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.42904245
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40613829
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40162492
38RNF2_27304074_Chip-Seq_NSC_Mouse1.39321034
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37059052
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.33009409
41AHR_22903824_ChIP-Seq_MCF-7_Human1.32583968
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32397318
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32397318
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32397318
45REST_21632747_ChIP-Seq_MESCs_Mouse1.32263014
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30502614
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30374864
48SMAD4_21799915_ChIP-Seq_A2780_Human1.29666866
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.29153323
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.28260210
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26545741
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.26335065
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24019043
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21407334
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20990395
56RUNX2_22187159_ChIP-Seq_PCA_Human1.19789008
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19363754
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14778862
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12507832
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10146734
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09232436
62SMAD4_21741376_ChIP-Seq_HESCs_Human1.07826350
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07181686
64GATA1_19941826_ChIP-Seq_K562_Human1.05620425
65SMAD3_21741376_ChIP-Seq_HESCs_Human1.05583333
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04134235
67TAF15_26573619_Chip-Seq_HEK293_Human1.03738836
68CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02422857
69BCAT_22108803_ChIP-Seq_LS180_Human1.01937047
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01202533
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01202533
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.00763844
73RNF2_27304074_Chip-Seq_ESCs_Mouse0.98978101
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98079054
75CDX2_20551321_ChIP-Seq_CACO-2_Human0.97632835
76CBX2_27304074_Chip-Seq_ESCs_Mouse0.97257995
77SMAD3_21741376_ChIP-Seq_ESCs_Human0.97219047
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96409314
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95914940
80TP53_18474530_ChIP-ChIP_U2OS_Human0.94813210
81PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94541307
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.93816598
83STAT3_23295773_ChIP-Seq_U87_Human0.93284821
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92755029
85P300_19829295_ChIP-Seq_ESCs_Human0.92227611
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91729267
87RXR_22108803_ChIP-Seq_LS180_Human0.91308977
88HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89749197
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89571673
90SCL_19346495_ChIP-Seq_HPC-7_Human0.89122518
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87758997
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86437120
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86254359
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85755085
95ISL1_27105846_Chip-Seq_CPCs_Mouse0.84121739
96REST_18959480_ChIP-ChIP_MESCs_Mouse0.83335296
97TP53_22573176_ChIP-Seq_HFKS_Human0.83233603
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80790708
99CBP_20019798_ChIP-Seq_JUKART_Human0.80790708
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.80643777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color4.04456616
2MP0003878_abnormal_ear_physiology3.82170858
3MP0005377_hearing/vestibular/ear_phenot3.82170858
4MP0001879_abnormal_lymphatic_vessel3.80779623
5MP0005084_abnormal_gallbladder_morpholo3.64984508
6MP0002653_abnormal_ependyma_morphology2.98262893
7MP0002928_abnormal_bile_duct2.71402911
8MP0001968_abnormal_touch/_nociception2.46344911
9MP0004147_increased_porphyrin_level2.38578684
10MP0005551_abnormal_eye_electrophysiolog2.34979017
11MP0001485_abnormal_pinna_reflex2.24549496
12MP0005423_abnormal_somatic_nervous2.19988466
13MP0003136_yellow_coat_color2.10150292
14MP0002735_abnormal_chemical_nociception2.08099609
15MP0002102_abnormal_ear_morphology2.03377028
16MP0004043_abnormal_pH_regulation1.91759257
17MP0004270_analgesia1.91513882
18MP0001501_abnormal_sleep_pattern1.90844183
19MP0003959_abnormal_lean_body1.90022052
20MP0000537_abnormal_urethra_morphology1.87284413
21MP0001986_abnormal_taste_sensitivity1.86025857
22MP0008872_abnormal_physiological_respon1.83371251
23MP0005085_abnormal_gallbladder_physiolo1.75001221
24MP0002733_abnormal_thermal_nociception1.71998870
25MP0002067_abnormal_sensory_capabilities1.70987947
26MP0002009_preneoplasia1.63601783
27MP0002163_abnormal_gland_morphology1.62880288
28MP0002138_abnormal_hepatobiliary_system1.62729499
29MP0001486_abnormal_startle_reflex1.59741468
30MP0009745_abnormal_behavioral_response1.59093878
31MP0009046_muscle_twitch1.52747089
32MP0002734_abnormal_mechanical_nocicepti1.50261722
33MP0002064_seizures1.48861427
34MP0005167_abnormal_blood-brain_barrier1.44359843
35MP0005083_abnormal_biliary_tract1.41864351
36MP0000767_abnormal_smooth_muscle1.41546558
37MP0001664_abnormal_digestion1.39569281
38MP0004924_abnormal_behavior1.36557915
39MP0005386_behavior/neurological_phenoty1.36557915
40MP0003183_abnormal_peptide_metabolism1.36037745
41MP0004142_abnormal_muscle_tone1.35104381
42MP0000750_abnormal_muscle_regeneration1.35054343
43MP0002089_abnormal_postnatal_growth/wei1.34731560
44MP0001440_abnormal_grooming_behavior1.31611513
45MP0002277_abnormal_respiratory_mucosa1.29247980
46MP0002736_abnormal_nociception_after1.28612375
47MP0001970_abnormal_pain_threshold1.27807062
48MP0003137_abnormal_impulse_conducting1.24574551
49MP0000631_abnormal_neuroendocrine_gland1.24473531
50MP0000026_abnormal_inner_ear1.23965712
51MP0001188_hyperpigmentation1.22393387
52MP0001963_abnormal_hearing_physiology1.18744134
53MP0005195_abnormal_posterior_eye1.18651887
54MP0003635_abnormal_synaptic_transmissio1.18148289
55MP0010386_abnormal_urinary_bladder1.14816715
56MP0004133_heterotaxia1.12423256
57MP0000516_abnormal_urinary_system1.10659216
58MP0005367_renal/urinary_system_phenotyp1.10659216
59MP0001324_abnormal_eye_pigmentation1.10590295
60MP0008877_abnormal_DNA_methylation1.10568968
61MP0002572_abnormal_emotion/affect_behav1.09071167
62MP0000343_altered_response_to1.08402857
63MP0005248_abnormal_Harderian_gland1.08273694
64MP0002272_abnormal_nervous_system1.07786064
65MP0000778_abnormal_nervous_system1.07375483
66MP0001851_eye_inflammation1.03466234
67MP0003638_abnormal_response/metabolism_1.03321400
68MP0003567_abnormal_fetal_cardiomyocyte1.01871390
69MP0008058_abnormal_DNA_repair1.01066750
70MP0005253_abnormal_eye_physiology0.99621628
71MP0002063_abnormal_learning/memory/cond0.98222594
72MP0009053_abnormal_anal_canal0.95966395
73MP0003943_abnormal_hepatobiliary_system0.95929621
74MP0004742_abnormal_vestibular_system0.94223279
75MP0002557_abnormal_social/conspecific_i0.93044643
76MP0008961_abnormal_basal_metabolism0.88957060
77MP0005379_endocrine/exocrine_gland_phen0.85512874
78MP0002405_respiratory_system_inflammati0.83831261
79MP0005646_abnormal_pituitary_gland0.82499497
80MP0005666_abnormal_adipose_tissue0.81638493
81MP0003279_aneurysm0.81569220
82MP0001502_abnormal_circadian_rhythm0.81563380
83MP0010368_abnormal_lymphatic_system0.81139559
84MP0000383_abnormal_hair_follicle0.80304992
85MP0001663_abnormal_digestive_system0.78596606
86MP0001944_abnormal_pancreas_morphology0.77962478
87MP0003950_abnormal_plasma_membrane0.77657318
88MP0004215_abnormal_myocardial_fiber0.76100378
89MP0002152_abnormal_brain_morphology0.73894738
90MP0002229_neurodegeneration0.73053504
91MP0003303_peritoneal_inflammation0.72581248
92MP0002098_abnormal_vibrissa_morphology0.71882395
93MP0002184_abnormal_innervation0.71300342
94MP0008874_decreased_physiological_sensi0.69343367
95MP0005332_abnormal_amino_acid0.69310821
96MP0003861_abnormal_nervous_system0.64646361
97MP0002752_abnormal_somatic_nervous0.64480950
98MP0001270_distended_abdomen0.64417562
99MP0002822_catalepsy0.63248151
100MP0002882_abnormal_neuron_morphology0.62979212

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.04825185
2Absent/shortened dynein arms (HP:0200106)5.04825185
3Congenital, generalized hypertrichosis (HP:0004540)4.57444922
4Diplopia (HP:0000651)4.54403120
5Abnormality of binocular vision (HP:0011514)4.54403120
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.22490743
7Congenital stationary night blindness (HP:0007642)4.01351239
8Hemiparesis (HP:0001269)3.95740738
9Tubular atrophy (HP:0000092)3.74179778
10Abnormal ciliary motility (HP:0012262)3.59540021
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.58689085
12Hypotrichosis (HP:0001006)3.50110400
13Entropion (HP:0000621)3.44716009
14Absent eyebrow (HP:0002223)3.44425848
15Poikiloderma (HP:0001029)3.42225518
16Abnormal respiratory epithelium morphology (HP:0012253)3.29487184
17Abnormal respiratory motile cilium morphology (HP:0005938)3.29487184
18Dyskinesia (HP:0100660)3.21973928
19Abnormal rod and cone electroretinograms (HP:0008323)3.21854691
20Morphological abnormality of the pyramidal tract (HP:0002062)3.17540685
21Confusion (HP:0001289)3.12212066
22Abnormal respiratory motile cilium physiology (HP:0012261)3.04963160
23Ventricular fibrillation (HP:0001663)2.99847428
24Limb dystonia (HP:0002451)2.98843288
25Curly hair (HP:0002212)2.94894548
26Broad-based gait (HP:0002136)2.75616639
27Paralysis (HP:0003470)2.75379152
28Nonimmune hydrops fetalis (HP:0001790)2.73801473
29Palpebral edema (HP:0100540)2.66813743
30J-shaped sella turcica (HP:0002680)2.65882854
31Inability to walk (HP:0002540)2.62955800
32High anterior hairline (HP:0009890)2.61744029
33Absent eyelashes (HP:0000561)2.56565234
34Partial agenesis of the corpus callosum (HP:0001338)2.53761306
35Concave nail (HP:0001598)2.51960035
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51918982
37Abnormality of alanine metabolism (HP:0010916)2.51918982
38Hyperalaninemia (HP:0003348)2.51918982
39Hypoplastic labia majora (HP:0000059)2.46847679
40Genetic anticipation (HP:0003743)2.45037607
41Hyperventilation (HP:0002883)2.42311639
42Poor eye contact (HP:0000817)2.40840676
43Increased number of teeth (HP:0011069)2.39017756
44Abnormality of the labia majora (HP:0012881)2.36071412
45Gait imbalance (HP:0002141)2.35555752
46Bony spicule pigmentary retinopathy (HP:0007737)2.34975628
47Pancreatic fibrosis (HP:0100732)2.34844716
48Long nose (HP:0003189)2.34758145
49Supernumerary spleens (HP:0009799)2.34719927
50Spastic paraplegia (HP:0001258)2.34672259
51Protruding tongue (HP:0010808)2.34238617
52Stomach cancer (HP:0012126)2.32100473
53Specific learning disability (HP:0001328)2.31617964
54Delayed CNS myelination (HP:0002188)2.31613898
55Progressive inability to walk (HP:0002505)2.29462138
56Short chin (HP:0000331)2.27934898
57Focal motor seizures (HP:0011153)2.22939113
58Abnormality of the sella turcica (HP:0002679)2.22251906
59Conjugated hyperbilirubinemia (HP:0002908)2.18017211
60Abnormal drinking behavior (HP:0030082)2.17272387
61Polydipsia (HP:0001959)2.17272387
62Birth length less than 3rd percentile (HP:0003561)2.17246101
63Absent hair (HP:0002298)2.16866311
64Recurrent bronchitis (HP:0002837)2.16513775
65Paraplegia (HP:0010550)2.15553125
66Nephrogenic diabetes insipidus (HP:0009806)2.13589176
67Rib fusion (HP:0000902)2.13316719
68Medial flaring of the eyebrow (HP:0010747)2.11721288
69Abnormality of DNA repair (HP:0003254)2.11371356
70Lymphedema (HP:0001004)2.09489234
71Turricephaly (HP:0000262)2.09118741
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09110313
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.09110313
74Cystic hygroma (HP:0000476)2.09071277
75Periorbital edema (HP:0100539)2.09007727
76Impaired social interactions (HP:0000735)2.06122608
77Abnormal social behavior (HP:0012433)2.06122608
78Decreased circulating renin level (HP:0003351)2.03565561
79Congenital primary aphakia (HP:0007707)1.98338754
80Blue irides (HP:0000635)1.98153325
81Hypoplastic ischia (HP:0003175)1.96983614
82Wide intermamillary distance (HP:0006610)1.96283952
83Facial edema (HP:0000282)1.96058918
84Pancreatic cysts (HP:0001737)1.95847996
85Bronchitis (HP:0012387)1.94432709
86Constricted visual fields (HP:0001133)1.94399334
87Focal seizures (HP:0007359)1.93682684
88Lymphangioma (HP:0100764)1.89946291
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88345018
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.87845079
91Urinary bladder sphincter dysfunction (HP:0002839)1.86675210
92Clumsiness (HP:0002312)1.84142464
93Epileptic encephalopathy (HP:0200134)1.83098059
94Type II lissencephaly (HP:0007260)1.80960990
95Generalized tonic-clonic seizures (HP:0002069)1.80346112
96Bronchiectasis (HP:0002110)1.79951961
97Breast hypoplasia (HP:0003187)1.77841415
98Labial hypoplasia (HP:0000066)1.77545177
99Heterotopia (HP:0002282)1.76338741
100Vertebral arch anomaly (HP:0008438)1.74546398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK68.71305907
2MAPK155.98595316
3TIE14.90376130
4STK164.36723972
5PNCK2.78940678
6WNK42.57533489
7CASK2.22071534
8STK391.81837415
9MST41.72948952
10NTRK21.64083784
11OXSR11.41049472
12EPHB21.35475259
13DAPK21.31696949
14MAP3K21.26405401
15MAPK131.20481849
16ACVR1B1.16534472
17STK241.14412797
18GRK11.12990296
19MAP3K31.12347128
20CDK31.11781517
21RPS6KA51.09348801
22MAPKAPK51.09180274
23PIM11.07621521
24BMPR1B1.04260061
25MAPKAPK31.03741245
26PDK21.02133828
27RPS6KA61.00038090
28FRK0.95984036
29VRK10.94585561
30PRKCQ0.93707824
31CAMK40.93667900
32DYRK30.89471801
33NEK90.87534886
34CDK120.86684491
35MARK10.86646095
36IRAK10.86006308
37MAP3K70.85497463
38SGK20.79595213
39EEF2K0.79508617
40PIM20.76928600
41UHMK10.76861426
42TYRO30.76471643
43MARK20.75596571
44SGK2230.74252099
45SGK4940.74252099
46MAP2K20.73685242
47PKN10.73461266
48SIK10.72020460
49PRKCG0.64671164
50ADRBK10.64498521
51MAP4K20.63797247
52ADRBK20.61545632
53CAMK2A0.59925661
54CSNK1G20.58732286
55IRAK20.55438032
56STK38L0.55103875
57BCR0.53009599
58CAMKK20.52677731
59DYRK1B0.52530887
60ICK0.49633370
61PHKG20.47620750
62PHKG10.47620750
63SIK20.46722770
64DYRK1A0.45823888
65RPS6KC10.45281744
66RPS6KL10.45281744
67WEE10.44893804
68STK110.44398572
69PRKD10.43069364
70RPS6KA10.42177135
71SGK10.42021180
72CHUK0.41574603
73CAMK10.40791652
74AKT20.36607435
75MAP3K40.36088666
76PLK40.35777046
77CAMK2G0.35593036
78CDK90.35527965
79PIK3CA0.35446588
80MATK0.34708531
81NTRK10.34531474
82RPS6KB10.34412698
83CAMK2B0.34186554
84LMTK20.33597235
85RPS6KA20.33583404
86MAPK120.32709063
87WNK30.32528445
88IRAK40.32216530
89SGK30.31922293
90TEC0.29556133
91GSK3A0.28967909
92CSNK1G10.28884870
93MAPK30.27592711
94MAPK10.26361491
95RPS6KA30.26089089
96MAP2K10.26074775
97INSRR0.26069836
98CSNK1G30.24111912
99CAMK2D0.23735709
100CSNK1A1L0.23714117

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.59016546
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81819154
3Linoleic acid metabolism_Homo sapiens_hsa005912.64558874
4Vitamin B6 metabolism_Homo sapiens_hsa007502.60147030
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.59492211
6Nitrogen metabolism_Homo sapiens_hsa009102.48018405
7Amphetamine addiction_Homo sapiens_hsa050312.38707918
8Dorso-ventral axis formation_Homo sapiens_hsa043202.23266972
9Ether lipid metabolism_Homo sapiens_hsa005652.20360858
10Prion diseases_Homo sapiens_hsa050202.17909957
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06754566
12Glutamatergic synapse_Homo sapiens_hsa047241.96877332
13African trypanosomiasis_Homo sapiens_hsa051431.88825326
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83455929
15B cell receptor signaling pathway_Homo sapiens_hsa046621.73916353
16MAPK signaling pathway_Homo sapiens_hsa040101.68996797
17ABC transporters_Homo sapiens_hsa020101.66321798
18Estrogen signaling pathway_Homo sapiens_hsa049151.53394398
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53337379
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39312743
21Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.35603170
22Cholinergic synapse_Homo sapiens_hsa047251.34910843
23Cocaine addiction_Homo sapiens_hsa050301.34838460
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30979608
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.27755762
26Axon guidance_Homo sapiens_hsa043601.23978765
27Long-term depression_Homo sapiens_hsa047301.20980565
28Oxytocin signaling pathway_Homo sapiens_hsa049211.16470286
29Insulin secretion_Homo sapiens_hsa049111.15820769
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15739983
31Serotonergic synapse_Homo sapiens_hsa047261.12452733
32Circadian entrainment_Homo sapiens_hsa047131.10644249
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08271441
34Arachidonic acid metabolism_Homo sapiens_hsa005901.07932226
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07305526
36Phototransduction_Homo sapiens_hsa047441.05767398
37Taste transduction_Homo sapiens_hsa047421.05474882
38Bile secretion_Homo sapiens_hsa049761.03546038
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02959371
40Calcium signaling pathway_Homo sapiens_hsa040201.02328215
41Glucagon signaling pathway_Homo sapiens_hsa049220.99896526
42Renin secretion_Homo sapiens_hsa049240.97846794
43Gastric acid secretion_Homo sapiens_hsa049710.97432643
44GnRH signaling pathway_Homo sapiens_hsa049120.96570752
45Renal cell carcinoma_Homo sapiens_hsa052110.96169617
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91961130
47GABAergic synapse_Homo sapiens_hsa047270.91498382
48TNF signaling pathway_Homo sapiens_hsa046680.90872994
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86309992
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85450633
51VEGF signaling pathway_Homo sapiens_hsa043700.82836836
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82062762
53T cell receptor signaling pathway_Homo sapiens_hsa046600.81958774
54Ras signaling pathway_Homo sapiens_hsa040140.81290412
55Ovarian steroidogenesis_Homo sapiens_hsa049130.79811470
56Legionellosis_Homo sapiens_hsa051340.79646428
57Dopaminergic synapse_Homo sapiens_hsa047280.77891959
58Notch signaling pathway_Homo sapiens_hsa043300.77158843
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74324338
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72480995
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.71638997
62Morphine addiction_Homo sapiens_hsa050320.68283793
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.66679076
64Rap1 signaling pathway_Homo sapiens_hsa040150.66296169
65Choline metabolism in cancer_Homo sapiens_hsa052310.65364320
66Long-term potentiation_Homo sapiens_hsa047200.64209622
67ErbB signaling pathway_Homo sapiens_hsa040120.60573282
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59133489
69Histidine metabolism_Homo sapiens_hsa003400.58362228
70Hippo signaling pathway_Homo sapiens_hsa043900.58147623
71Wnt signaling pathway_Homo sapiens_hsa043100.57852370
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56816174
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53704050
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49726891
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49681202
76Olfactory transduction_Homo sapiens_hsa047400.49066929
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48126957
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.48080887
79Basal transcription factors_Homo sapiens_hsa030220.47052171
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.44813657
81Sphingolipid metabolism_Homo sapiens_hsa006000.44142318
82cAMP signaling pathway_Homo sapiens_hsa040240.44091880
83Rheumatoid arthritis_Homo sapiens_hsa053230.42705761
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41527017
85TGF-beta signaling pathway_Homo sapiens_hsa043500.40536619
86Fat digestion and absorption_Homo sapiens_hsa049750.39802280
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39515923
88Malaria_Homo sapiens_hsa051440.39094341
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.38632896
90Chemical carcinogenesis_Homo sapiens_hsa052040.38182003
91Inositol phosphate metabolism_Homo sapiens_hsa005620.34738468
92Tryptophan metabolism_Homo sapiens_hsa003800.34655152
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34546285
94Endometrial cancer_Homo sapiens_hsa052130.34481784
95Antigen processing and presentation_Homo sapiens_hsa046120.33412305
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32430234
97Starch and sucrose metabolism_Homo sapiens_hsa005000.31977238
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30165306
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.29694701
100Toxoplasmosis_Homo sapiens_hsa051450.29613170

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