ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of G0 to G1 transition (GO:0070316)	9.94349085
2	epithelial structure maintenance (GO:0010669)	8.31595400
3	urogenital system development (GO:0001655)	7.84615884
4	response to vitamin A (GO:0033189)	7.27306074
5	bone trabecula formation (GO:0060346)	7.15809123
6	cellular response to epidermal growth factor stimulus (GO:0071364)	6.53766414
7	cerebellar Purkinje cell differentiation (GO:0021702)	6.50062328
8	regulation of ARF GTPase activity (GO:0032312)	6.35106322
9	O-glycan processing (GO:0016266)	6.15576861
10	positive regulation of gastrulation (GO:2000543)	5.95676884
11	thalamus development (GO:0021794)	5.73106405
12	primitive streak formation (GO:0090009)	5.72929500
13	neurotransmitter catabolic process (GO:0042135)	5.60583664
14	protein targeting to Golgi (GO:0000042)	5.36446817
15	response to epidermal growth factor (GO:0070849)	5.21949302
16	establishment of protein localization to Golgi (GO:0072600)	5.14801820
17	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.11877592
18	dendritic spine morphogenesis (GO:0060997)	5.00512660
19	forebrain neuron development (GO:0021884)	4.93147135
20	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	4.72868912
21	trivalent inorganic anion homeostasis (GO:0072506)	4.70542363
22	phosphate ion homeostasis (GO:0055062)	4.70542363
23	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	4.60552321
24	uterus development (GO:0060065)	4.57922503
25	head development (GO:0060322)	4.56961270
26	somite rostral/caudal axis specification (GO:0032525)	4.53406638
27	cerebellum development (GO:0021549)	4.45790804
28	endoderm formation (GO:0001706)	4.40790075
29	protein O-linked glycosylation (GO:0006493)	4.38066976
30	negative regulation of digestive system process (GO:0060457)	4.38064674
31	spinal cord association neuron differentiation (GO:0021527)	4.36644959
32	cellular anion homeostasis (GO:0030002)	4.27411425
33	cellular response to glucocorticoid stimulus (GO:0071385)	4.26846783
34	glomerulus development (GO:0032835)	4.22019619
35	embryonic viscerocranium morphogenesis (GO:0048703)	4.15805595
36	nephron tubule morphogenesis (GO:0072078)	4.15402612
37	nephron epithelium morphogenesis (GO:0072088)	4.15402612
38	cellular response to corticosteroid stimulus (GO:0071384)	4.15262048
39	retina layer formation (GO:0010842)	4.05181809
40	protein localization to Golgi apparatus (GO:0034067)	4.01562939
41	membrane repolarization during action potential (GO:0086011)	4.01115454
42	phospholipid scrambling (GO:0017121)	3.97601163
43	peptidyl-arginine omega-N-methylation (GO:0035247)	3.95772557
44	fucose catabolic process (GO:0019317)	3.72031836
45	L-fucose metabolic process (GO:0042354)	3.72031836
46	L-fucose catabolic process (GO:0042355)	3.72031836
47	dendritic spine organization (GO:0097061)	3.69665256
48	vagina development (GO:0060068)	3.69113515
49	C21-steroid hormone biosynthetic process (GO:0006700)	3.68752971
50	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.66398026
51	cell differentiation in hindbrain (GO:0021533)	3.64394348
52	female genitalia development (GO:0030540)	3.60868806
53	hematopoietic stem cell proliferation (GO:0071425)	3.59310916
54	vocalization behavior (GO:0071625)	3.48412146
55	peptidyl-arginine methylation (GO:0018216)	3.47253399
56	peptidyl-arginine N-methylation (GO:0035246)	3.47253399
57	telencephalon development (GO:0021537)	3.41794454
58	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.29282167
59	sister chromatid cohesion (GO:0007062)	3.23657001
60	regulation of neuron migration (GO:2001222)	3.22025650
61	gastrulation with mouth forming second (GO:0001702)	3.13154333
62	digestive system process (GO:0022600)	3.07390448
63	granulocyte differentiation (GO:0030851)	3.05095244
64	GDP-mannose metabolic process (GO:0019673)	3.04600642
65	regulation of meiosis I (GO:0060631)	3.03585594
66	renal tubule morphogenesis (GO:0061333)	3.03252256
67	creatine metabolic process (GO:0006600)	3.01374333
68	viral protein processing (GO:0019082)	3.00265685
69	positive regulation of protein homooligomerization (GO:0032464)	2.98574348
70	glucocorticoid biosynthetic process (GO:0006704)	2.98500788
71	glucocorticoid receptor signaling pathway (GO:0042921)	2.94124952
72	renal absorption (GO:0070293)	2.93961689
73	fucosylation (GO:0036065)	2.93893314
74	regulation of cholesterol homeostasis (GO:2000188)	2.92960779
75	cartilage condensation (GO:0001502)	2.91719217
76	cell aggregation (GO:0098743)	2.91719217
77	histone H3-K9 demethylation (GO:0033169)	2.90817179
78	long term synaptic depression (GO:0060292)	2.89161028
79	ncRNA 3-end processing (GO:0043628)	2.88528227
80	motor neuron axon guidance (GO:0008045)	2.84915401
81	myoblast fusion (GO:0007520)	2.84813093
82	DNA double-strand break processing (GO:0000729)	2.83387077
83	calcium ion import (GO:0070509)	2.82657165
84	histone arginine methylation (GO:0034969)	2.81223376
85	photoreceptor cell maintenance (GO:0045494)	2.80607445
86	cilium or flagellum-dependent cell motility (GO:0001539)	2.76911987
87	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.76788362
88	corticosteroid receptor signaling pathway (GO:0031958)	2.76576491
89	determination of adult lifespan (GO:0008340)	2.74549128
90	establishment of skin barrier (GO:0061436)	2.72659539
91	rRNA catabolic process (GO:0016075)	2.69991607
92	central nervous system neuron development (GO:0021954)	2.69152072
93	histone H3-K4 trimethylation (GO:0080182)	2.69026036
94	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.68116647
95	cranial nerve structural organization (GO:0021604)	2.67256573
96	collecting duct development (GO:0072044)	2.67017899
97	positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)	2.64815708
98	DNA synthesis involved in DNA repair (GO:0000731)	2.64762787
99	maintenance of gastrointestinal epithelium (GO:0030277)	11.3688923
100	embryonic retina morphogenesis in camera-type eye (GO:0060059)	10.9258123

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	6.00114361
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.62779754
3	DROSHA_22980978_ChIP-Seq_HELA_Human	4.37357440
4	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.93886063
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.89586791
6	WDR5_24793694_ChIP-Seq_LNCAP_Human	2.65513068
7	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.12206178
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.07869135
9	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.02005540
10	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.94291783
11	SMC4_20622854_ChIP-Seq_HELA_Human	1.91024858
12	AR_21572438_ChIP-Seq_LNCaP_Human	1.90570065
13	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.89780225
14	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.82147175
15	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.80676350
16	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.77817084
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.66665738
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.63571201
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.63481347
20	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.62559160
21	CTCF_27219007_Chip-Seq_Bcells_Human	1.60590387
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.60361678
23	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.59083035
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.53023987
25	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.51418220
26	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.47984860
27	VDR_22108803_ChIP-Seq_LS180_Human	1.47539077
28	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.44530355
29	OCT4_19829295_ChIP-Seq_ESCs_Human	1.40778540
30	KDM2B_26808549_Chip-Seq_K562_Human	1.39857218
31	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.37419783
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.36730138
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.36730138
34	GATA6_25053715_ChIP-Seq_YYC3_Human	1.36124246
35	AHR_22903824_ChIP-Seq_MCF-7_Human	1.33947413
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.33839575
37	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.31168728
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30510663
39	E2F1_20622854_ChIP-Seq_HELA_Human	1.30401822
40	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.27993151
41	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.25592511
42	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.25076314
43	KLF5_25053715_ChIP-Seq_YYC3_Human	1.24978291
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24861078
45	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.24212982
46	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.21415092
47	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.20909283
48	BCL6_27268052_Chip-Seq_Bcells_Human	1.18783615
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.18142752
50	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.17292317
51	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.16312142
52	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.15703297
53	P68_20966046_ChIP-Seq_HELA_Human	1.13022191
54	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.11881252
55	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.10990741
56	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.10504274
57	CREB1_26743006_Chip-Seq_LNCaP_Human	1.09811861
58	LXR_22292898_ChIP-Seq_THP-1_Human	1.09543059
59	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09378555
60	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.08627083
61	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.08192227
62	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.07592475
63	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06828564
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06517845
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04395559
66	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04226900
67	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02612715
68	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.02430289
69	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.01953067
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01677163
71	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.01303980
72	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.01292440
73	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.00779011
74	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.00626623
75	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.99772764
76	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.99378405
77	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.99364386
78	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.98885448
79	KLF4_19829295_ChIP-Seq_ESCs_Human	0.98546417
80	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.98153967
81	ER_23166858_ChIP-Seq_MCF-7_Human	0.96548907
82	PHF8_20622854_ChIP-Seq_HELA_Human	0.96351786
83	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.94486513
84	MYC_19915707_ChIP-ChIP_AK7_Human	0.94243948
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93146674
86	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.93145559
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91602512
88	STAT3_23295773_ChIP-Seq_U87_Human	0.91211220
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.91185555
90	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.90998482
91	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.90340849
92	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89305377
93	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.89184834
94	TBL1_22424771_ChIP-Seq_293T_Human	0.88364890
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.88247921
96	SA1_27219007_Chip-Seq_Bcells_Human	0.88174526
97	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.87647992
98	CBP_21632823_ChIP-Seq_H3396_Human	0.86355819
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.86245855
100	NFYA_21822215_ChIP-Seq_K562_Human	0.85245360

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.01458669
2	MP0005257_abnormal_intraocular_pressure	4.69595484
3	MP0003890_abnormal_embryonic-extraembry	4.58802785
4	MP0000465_gastrointestinal_hemorrhage	4.35275683
5	MP0008004_abnormal_stomach_pH	3.89212278
6	MP0000566_synostosis	3.82402852
7	MP0004043_abnormal_pH_regulation	3.32176220
8	MP0003879_abnormal_hair_cell	3.25658494
9	MP0001348_abnormal_lacrimal_gland	2.90833060
10	MP0000579_abnormal_nail_morphology	2.89295961
11	MP0002138_abnormal_hepatobiliary_system	2.86157897
12	MP0005377_hearing/vestibular/ear_phenot	2.73188955
13	MP0003878_abnormal_ear_physiology	2.73188955
14	MP0005083_abnormal_biliary_tract	2.49398637
15	MP0003866_abnormal_defecation	2.38781153
16	MP0004742_abnormal_vestibular_system	2.19673623
17	MP0001485_abnormal_pinna_reflex	2.13211487
18	MP0008995_early_reproductive_senescence	2.10296303
19	MP0001666_abnormal_nutrient_absorption	1.97831299
20	MP0005275_abnormal_skin_tensile	1.96230706
21	MP0000538_abnormal_urinary_bladder	1.85134613
22	MP0002127_abnormal_cardiovascular_syste	1.70103529
23	MP0000026_abnormal_inner_ear	1.68832080
24	MP0008438_abnormal_cutaneous_collagen	1.65289004
25	MP0003705_abnormal_hypodermis_morpholog	1.60555176
26	MP0001664_abnormal_digestion	1.58395964
27	MP0001849_ear_inflammation	1.55180453
28	MP0005220_abnormal_exocrine_pancreas	1.55094871
29	MP0001765_abnormal_ion_homeostasis	1.50917431
30	MP0003091_abnormal_cell_migration	1.47598035
31	MP0003136_yellow_coat_color	1.45773847
32	MP0001188_hyperpigmentation	1.44660976
33	MP0003279_aneurysm	1.42220716
34	MP0000049_abnormal_middle_ear	1.41821743
35	MP0001663_abnormal_digestive_system	1.38252313
36	MP0010155_abnormal_intestine_physiology	1.35923165
37	MP0000383_abnormal_hair_follicle	1.34219533
38	MP0002877_abnormal_melanocyte_morpholog	1.26661109
39	MP0001963_abnormal_hearing_physiology	1.24044146
40	MP0003880_abnormal_central_pattern	1.23819334
41	MP0010368_abnormal_lymphatic_system	1.23371602
42	MP0002184_abnormal_innervation	1.21390627
43	MP0000647_abnormal_sebaceous_gland	1.19110682
44	MP0010678_abnormal_skin_adnexa	1.18045147
45	MP0003938_abnormal_ear_development	1.17501078
46	MP0010234_abnormal_vibrissa_follicle	1.15859806
47	MP0005381_digestive/alimentary_phenotyp	1.14912812
48	MP0004019_abnormal_vitamin_homeostasis	1.12121026
49	MP0003300_gastrointestinal_ulcer	1.09515229
50	MP0000015_abnormal_ear_pigmentation	1.08260079
51	MP0001502_abnormal_circadian_rhythm	1.04762037
52	MP0003252_abnormal_bile_duct	1.02983003
53	MP0001270_distended_abdomen	0.97354482
54	MP0001286_abnormal_eye_development	0.94747881
55	MP0002060_abnormal_skin_morphology	0.89489554
56	MP0002822_catalepsy	0.88839567
57	MP0002928_abnormal_bile_duct	0.87705614
58	MP0002210_abnormal_sex_determination	0.87124407
59	MP0005551_abnormal_eye_electrophysiolog	0.86034014
60	MP0005409_darkened_coat_color	0.84796984
61	MP0005076_abnormal_cell_differentiation	0.82278590
62	MP0001299_abnormal_eye_distance/	0.81380292
63	MP0000955_abnormal_spinal_cord	0.80303830
64	MP0003385_abnormal_body_wall	0.79125366
65	MP0001243_abnormal_dermal_layer	0.78611393
66	MP0003948_abnormal_gas_homeostasis	0.76829233
67	MP0003567_abnormal_fetal_cardiomyocyte	0.76173125
68	MP0005645_abnormal_hypothalamus_physiol	0.74774375
69	MP0000477_abnormal_intestine_morphology	0.74338629
70	MP0002098_abnormal_vibrissa_morphology	0.74248458
71	MP0002882_abnormal_neuron_morphology	0.71875605
72	MP0001958_emphysema	0.71499980
73	MP0000778_abnormal_nervous_system	0.71035470
74	MP0008932_abnormal_embryonic_tissue	0.70612980
75	MP0002653_abnormal_ependyma_morphology	0.69969812
76	MP0003943_abnormal_hepatobiliary_system	0.69512833
77	MP0005310_abnormal_salivary_gland	0.68546391
78	MP0004147_increased_porphyrin_level	0.66558122
79	MP0001879_abnormal_lymphatic_vessel	0.66288259
80	MP0008775_abnormal_heart_ventricle	0.65236334
81	MP0005670_abnormal_white_adipose	0.64396206
82	MP0002229_neurodegeneration	0.63256572
83	MP0006276_abnormal_autonomic_nervous	0.61612997
84	MP0001661_extended_life_span	0.60988541
85	MP0003936_abnormal_reproductive_system	0.60599121
86	MP0002095_abnormal_skin_pigmentation	0.60102515
87	MP0002752_abnormal_somatic_nervous	0.57948757
88	MP0001324_abnormal_eye_pigmentation	0.57562074
89	MP0002896_abnormal_bone_mineralization	0.56762825
90	MP0005394_taste/olfaction_phenotype	0.56648078
91	MP0005499_abnormal_olfactory_system	0.56648078
92	MP0003959_abnormal_lean_body	0.55652316
93	MP0000432_abnormal_head_morphology	0.55412224
94	MP0002697_abnormal_eye_size	0.54880312
95	MP0000428_abnormal_craniofacial_morphol	0.51274473
96	MP0008057_abnormal_DNA_replication	0.51003340
97	MP0001145_abnormal_male_reproductive	0.50885898
98	MP0003137_abnormal_impulse_conducting	0.47246504
99	MP0001944_abnormal_pancreas_morphology	0.47238879
100	MP0003283_abnormal_digestive_organ	0.47097714

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal pancreas size (HP:0012094)	5.91163858
2	Thin bony cortex (HP:0002753)	5.63780850
3	Pili torti (HP:0003777)	5.07643381
4	Palpebral edema (HP:0100540)	4.69086199
5	Hypophosphatemic rickets (HP:0004912)	4.35243106
6	Abnormality of dentin (HP:0010299)	4.07044903
7	Genu recurvatum (HP:0002816)	3.96749681
8	Enlarged epiphyses (HP:0010580)	3.96463151
9	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.88397653
10	Chromsome breakage (HP:0040012)	3.85562774
11	Mask-like facies (HP:0000298)	3.84652476
12	Hyperkalemia (HP:0002153)	3.79378756
13	Bilateral sensorineural hearing impairment (HP:0008619)	3.52430717
14	Congenital sensorineural hearing impairment (HP:0008527)	3.47569992
15	Abnormality of DNA repair (HP:0003254)	3.39302320
16	Decreased circulating renin level (HP:0003351)	3.38995144
17	Abnormal hair laboratory examination (HP:0003328)	3.33075571
18	Tibial bowing (HP:0002982)	3.25044460
19	Distal upper limb amyotrophy (HP:0007149)	3.18853039
20	Upper limb amyotrophy (HP:0009129)	3.18853039
21	Delayed epiphyseal ossification (HP:0002663)	3.16280060
22	Shawl scrotum (HP:0000049)	3.13535792
23	Hemorrhage of the eye (HP:0011885)	3.13412415
24	Abnormality of chloride homeostasis (HP:0011422)	3.05526470
25	Broad metatarsal (HP:0001783)	3.04232822
26	Patent foramen ovale (HP:0001655)	3.04203043
27	Ectopic kidney (HP:0000086)	2.92152829
28	Duplicated collecting system (HP:0000081)	2.90430507
29	Long eyelashes (HP:0000527)	2.84043830
30	Morphological abnormality of the middle ear (HP:0008609)	2.79475780
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.78412087
32	Large eyes (HP:0001090)	2.72996517
33	Abnormality of the costochondral junction (HP:0000919)	2.72336922
34	Reticulocytopenia (HP:0001896)	2.66515368
35	Abnormality of the right ventricle (HP:0001707)	2.66073292
36	Abnormality of chromosome stability (HP:0003220)	2.62854796
37	Fragile skin (HP:0001030)	2.61307689
38	Cerebral aneurysm (HP:0004944)	2.58063052
39	Spinal muscular atrophy (HP:0007269)	2.55798321
40	Abnormality of the renal collecting system (HP:0004742)	2.49984903
41	Abnormality of the nasal septum (HP:0000419)	2.38257203
42	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.36435696
43	Short 1st metacarpal (HP:0010034)	2.36435696
44	Atrophic scars (HP:0001075)	2.35453112
45	Abnormality of the lower motor neuron (HP:0002366)	2.34530564
46	Abnormality of pyrimidine metabolism (HP:0004353)	2.31129949
47	Hand muscle atrophy (HP:0009130)	2.30606867
48	Abnormality of hair growth rate (HP:0011363)	2.28667195
49	Slow-growing hair (HP:0002217)	2.28667195
50	Tubulointerstitial nephritis (HP:0001970)	2.28162956
51	Abnormality of the 1st metacarpal (HP:0010009)	2.26114643
52	Duplication of thumb phalanx (HP:0009942)	2.24630544
53	Abnormality of the distal phalanges of the toes (HP:0010182)	2.24569936
54	Nuclear cataract (HP:0100018)	2.22546931
55	Neonatal short-limb short stature (HP:0008921)	2.19751568
56	Abnormality of renin-angiotensin system (HP:0000847)	2.17627398
57	Abnormality of the carotid arteries (HP:0005344)	2.15208132
58	Supranuclear gaze palsy (HP:0000605)	2.11492861
59	Milia (HP:0001056)	2.10785858
60	Pigmentary retinal degeneration (HP:0001146)	2.10379655
61	Mitral valve prolapse (HP:0001634)	2.08480083
62	Widely patent fontanelles and sutures (HP:0004492)	2.07401024
63	Long palpebral fissure (HP:0000637)	2.07226392
64	Rickets (HP:0002748)	2.06618502
65	Short phalanx of the thumb (HP:0009660)	2.02939268
66	Abnormality of the preputium (HP:0100587)	2.02863377
67	Ureteral duplication (HP:0000073)	2.02605066
68	Malnutrition (HP:0004395)	2.00088830
69	Periorbital edema (HP:0100539)	2.00003226
70	Mild short stature (HP:0003502)	1.98787011
71	Villous atrophy (HP:0011473)	1.94745418
72	Abnormality of small intestinal villus morphology (HP:0011472)	1.94745418
73	Facial edema (HP:0000282)	1.94688005
74	Abnormality of potassium homeostasis (HP:0011042)	1.91386738
75	Abnormality of the ileum (HP:0001549)	1.90199772
76	Meckel diverticulum (HP:0002245)	1.89767601
77	Aortic dissection (HP:0002647)	1.87520176
78	Clubbing of toes (HP:0100760)	1.86419905
79	Abnormality of the aortic arch (HP:0012303)	1.85615539
80	Mildly elevated creatine phosphokinase (HP:0008180)	1.84975184
81	Difficulty climbing stairs (HP:0003551)	1.83847753
82	Hyperactive renin-angiotensin system (HP:0000841)	1.82727989
83	Femoral bowing (HP:0002980)	1.81671289
84	Cystic liver disease (HP:0006706)	1.80865433
85	Distal lower limb amyotrophy (HP:0008944)	1.78745230
86	Abnormal cortical bone morphology (HP:0003103)	1.77783762
87	Subcapsular cataract (HP:0000523)	1.77674489
88	Peritonitis (HP:0002586)	1.77597408
89	Bowel diverticulosis (HP:0005222)	1.77332342
90	Difficulty walking (HP:0002355)	1.76362588
91	Abnormality of the fingertips (HP:0001211)	1.76339506
92	Male infertility (HP:0003251)	1.76235808
93	Ependymoma (HP:0002888)	1.75987182
94	Thoracolumbar scoliosis (HP:0002944)	1.75651280
95	Short nail (HP:0001799)	1.73395557
96	Chronic bronchitis (HP:0004469)	1.71956475
97	Neoplasm of striated muscle (HP:0009728)	1.71338480
98	Cubitus valgus (HP:0002967)	1.70344557
99	Abnormality of cochlea (HP:0000375)	1.69991191
100	Deep palmar crease (HP:0006191)	1.69928861

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	7.64738874
2	MST1R	7.06811562
3	NME1	5.10406993
4	WNK1	4.01233597
5	MET	2.84817498
6	CDK12	2.59805827
7	MAP3K13	2.27513749
8	NEK2	1.77483239
9	BRD4	1.68493851
10	STK39	1.66918962
11	ERN1	1.65050010
12	BCR	1.38168574
13	ERBB2	1.37248228
14	TAOK1	1.28903705
15	SIK2	1.27896502
16	STK24	1.23562051
17	CAMK1G	1.19180899
18	LMTK2	1.18108105
19	CASK	1.15933461
20	NEK6	1.09814005
21	MUSK	1.09254840
22	MAP2K6	1.08752625
23	MARK2	1.08247127
24	CAMK1D	1.05667243
25	MAP3K7	1.05387991
26	PDGFRB	1.03873970
27	ACVR1B	1.00162520
28	TNIK	0.99945888
29	BLK	0.97075948
30	TRPM7	0.96047016
31	PINK1	0.93123000
32	PLK4	0.86866717
33	CHUK	0.83930049
34	ADRBK2	0.82973534
35	ICK	0.82571641
36	MAP2K2	0.82423271
37	MAP3K9	0.81288405
38	TYRO3	0.78679795
39	BCKDK	0.77689405
40	FGFR4	0.73567291
41	DYRK1B	0.73468812
42	OXSR1	0.73072931
43	INSRR	0.71735806
44	KSR1	0.71541286
45	TEC	0.69851045
46	SGK1	0.68433454
47	FGFR2	0.66734508
48	MAPK15	0.64181860
49	NTRK2	0.63606777
50	PRKCI	0.61536883
51	MELK	0.61187313
52	EPHA2	0.60582361
53	MAP3K6	0.56656921
54	PDGFRA	0.55708320
55	EPHB2	0.54917675
56	PAK3	0.53989787
57	CDC42BPA	0.53159748
58	PRKAA2	0.52812105
59	MTOR	0.52541097
60	ARAF	0.48976097
61	PRKCQ	0.48934121
62	MAP3K2	0.47195225
63	YES1	0.46994166
64	CDK7	0.46501353
65	PRKCH	0.45930519
66	TNK2	0.43839754
67	DDR2	0.43719318
68	PIK3CG	0.39921597
69	RPS6KA2	0.39111617
70	BRAF	0.37724832
71	PRKD2	0.37234780
72	IKBKB	0.36796108
73	HCK	0.36334478
74	PASK	0.36080482
75	RET	0.34827024
76	ITK	0.33631672
77	PTK2B	0.32549093
78	MAP2K1	0.31098659
79	DYRK1A	0.30120799
80	PRKAA1	0.30074292
81	MKNK1	0.28838158
82	MAP4K2	0.27254129
83	MAPK1	0.26938119
84	PTK2	0.26923928
85	ADRBK1	0.25248832
86	RPS6KA6	0.25047342
87	RPS6KC1	0.25030787
88	RPS6KL1	0.25030787
89	PKN2	0.24048135
90	CDK8	0.24028058
91	KSR2	0.23674650
92	TESK2	0.23220449
93	RPS6KA3	0.22316193
94	IRAK4	0.22267346
95	EPHA4	0.22115765
96	PRKDC	0.21489602
97	MAPK11	0.20497023
98	TAF1	0.20390246
99	GSK3B	0.19339517
100	CHEK1	0.18943604

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	3.57545781
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.55436031
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.98713540
4	Oocyte meiosis_Homo sapiens_hsa04114	2.63354506
5	Salivary secretion_Homo sapiens_hsa04970	2.58307673
6	ABC transporters_Homo sapiens_hsa02010	2.29465317
7	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.26766501
8	Protein digestion and absorption_Homo sapiens_hsa04974	2.24537554
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	2.24081258
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.04815669
11	ECM-receptor interaction_Homo sapiens_hsa04512	2.03431298
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.95122416
13	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.94601159
14	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.72461225
15	Vibrio cholerae infection_Homo sapiens_hsa05110	1.67041251
16	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.61241055
17	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.56007667
18	Insulin secretion_Homo sapiens_hsa04911	1.48274628
19	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.44873463
20	Type II diabetes mellitus_Homo sapiens_hsa04930	1.42804772
21	GnRH signaling pathway_Homo sapiens_hsa04912	1.39082485
22	Amoebiasis_Homo sapiens_hsa05146	1.30202457
23	Pancreatic secretion_Homo sapiens_hsa04972	1.28726779
24	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.28527715
25	Gastric acid secretion_Homo sapiens_hsa04971	1.27608280
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.23015539
27	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.19234621
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.15886157
29	Taste transduction_Homo sapiens_hsa04742	1.14860756
30	Lysine degradation_Homo sapiens_hsa00310	1.14396644
31	Mineral absorption_Homo sapiens_hsa04978	1.13852415
32	Olfactory transduction_Homo sapiens_hsa04740	1.13703242
33	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.13230223
34	Malaria_Homo sapiens_hsa05144	1.10902566
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04319437
36	Bile secretion_Homo sapiens_hsa04976	1.01697024
37	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.99830142
38	Axon guidance_Homo sapiens_hsa04360	0.99426658
39	Other glycan degradation_Homo sapiens_hsa00511	0.93915487
40	cAMP signaling pathway_Homo sapiens_hsa04024	0.92191551
41	Circadian entrainment_Homo sapiens_hsa04713	0.90018918
42	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.89878946
43	Notch signaling pathway_Homo sapiens_hsa04330	0.88692382
44	Endometrial cancer_Homo sapiens_hsa05213	0.88272872
45	Cholinergic synapse_Homo sapiens_hsa04725	0.87761570
46	Calcium signaling pathway_Homo sapiens_hsa04020	0.87702666
47	Long-term depression_Homo sapiens_hsa04730	0.85907100
48	Choline metabolism in cancer_Homo sapiens_hsa05231	0.85267236
49	Homologous recombination_Homo sapiens_hsa03440	0.83127851
50	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.80264342
51	Nicotine addiction_Homo sapiens_hsa05033	0.77853811
52	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.75795452
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.73672045
54	Colorectal cancer_Homo sapiens_hsa05210	0.72984837
55	Mismatch repair_Homo sapiens_hsa03430	0.72675413
56	ErbB signaling pathway_Homo sapiens_hsa04012	0.71451063
57	VEGF signaling pathway_Homo sapiens_hsa04370	0.67961378
58	MicroRNAs in cancer_Homo sapiens_hsa05206	0.67198486
59	Basal transcription factors_Homo sapiens_hsa03022	0.66915514
60	Long-term potentiation_Homo sapiens_hsa04720	0.66158713
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.65904702
62	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.65739643
63	Prostate cancer_Homo sapiens_hsa05215	0.65104829
64	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64432412
65	Serotonergic synapse_Homo sapiens_hsa04726	0.63197351
66	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.61772145
67	Glutamatergic synapse_Homo sapiens_hsa04724	0.60737181
68	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.60709578
69	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.59180921
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55807593
71	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55624042
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.55050829
73	Non-small cell lung cancer_Homo sapiens_hsa05223	0.53931763
74	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.53633896
75	Platelet activation_Homo sapiens_hsa04611	0.53479463
76	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.51921480
77	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.51879499
78	Endocytosis_Homo sapiens_hsa04144	0.50978036
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50653481
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.50608684
81	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.49304832
82	Focal adhesion_Homo sapiens_hsa04510	0.48652433
83	Tight junction_Homo sapiens_hsa04530	0.48167623
84	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.46312522
85	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.45701872
86	Melanogenesis_Homo sapiens_hsa04916	0.45668559
87	MAPK signaling pathway_Homo sapiens_hsa04010	0.45514646
88	Rap1 signaling pathway_Homo sapiens_hsa04015	0.45473014
89	p53 signaling pathway_Homo sapiens_hsa04115	0.43889619
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43636691
91	Amphetamine addiction_Homo sapiens_hsa05031	0.43568517
92	Peroxisome_Homo sapiens_hsa04146	0.43422990
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.42108991
94	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40674594
95	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38981315
96	Melanoma_Homo sapiens_hsa05218	0.36790498
97	Gap junction_Homo sapiens_hsa04540	0.36468511
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35417192
99	Adherens junction_Homo sapiens_hsa04520	0.34907683
100	Insulin resistance_Homo sapiens_hsa04931	0.34774709

NUTM2HP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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