NVL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of DNA-dependent DNA replication (GO:2000104)4.20085644
2nuclear pore organization (GO:0006999)4.19765633
3nuclear pore complex assembly (GO:0051292)4.08654521
4regulation of DNA endoreduplication (GO:0032875)3.97049974
5kinetochore organization (GO:0051383)3.89467335
6maturation of 5.8S rRNA (GO:0000460)3.87604756
7regulation of nuclear cell cycle DNA replication (GO:0033262)3.83357160
8histone H3-K4 trimethylation (GO:0080182)3.69401015
9mitotic sister chromatid cohesion (GO:0007064)3.66096628
10kinetochore assembly (GO:0051382)3.62429434
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.58299347
12DNA double-strand break processing (GO:0000729)3.54360846
13microtubule depolymerization (GO:0007019)3.52913166
14pore complex assembly (GO:0046931)3.46258384
15meiotic chromosome segregation (GO:0045132)3.40561925
16DNA strand renaturation (GO:0000733)3.38122264
17mitotic metaphase plate congression (GO:0007080)3.38089775
18regulation of helicase activity (GO:0051095)3.29957947
19proteasome assembly (GO:0043248)3.26605524
20recombinational repair (GO:0000725)3.25534323
21protein K6-linked ubiquitination (GO:0085020)3.23817830
22double-strand break repair via homologous recombination (GO:0000724)3.23429951
23chromatin remodeling at centromere (GO:0031055)3.23200381
24mRNA splice site selection (GO:0006376)3.22495984
25centriole replication (GO:0007099)3.20146069
26pseudouridine synthesis (GO:0001522)3.19238000
27histone H3-K9 methylation (GO:0051567)3.17587514
28chaperone-mediated protein transport (GO:0072321)3.14822117
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14539739
30CENP-A containing nucleosome assembly (GO:0034080)3.14285901
31histone H2A acetylation (GO:0043968)3.13294125
32DNA replication initiation (GO:0006270)3.11518816
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08178517
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.07697747
35metaphase plate congression (GO:0051310)3.01310725
36mismatch repair (GO:0006298)3.00722147
37water-soluble vitamin biosynthetic process (GO:0042364)3.00593357
38mitochondrial RNA metabolic process (GO:0000959)2.99294117
39postreplication repair (GO:0006301)2.98541288
40spliceosomal snRNP assembly (GO:0000387)2.98103505
41protein-cofactor linkage (GO:0018065)2.95830489
42regulation of histone H3-K9 methylation (GO:0051570)2.94405535
43resolution of meiotic recombination intermediates (GO:0000712)2.91601843
44protein localization to kinetochore (GO:0034501)2.90924947
45telomere maintenance via telomerase (GO:0007004)2.90361960
46regulation of translation, ncRNA-mediated (GO:0045974)2.89356519
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.89356519
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.89356519
49DNA replication-dependent nucleosome organization (GO:0034723)2.88878405
50DNA replication-dependent nucleosome assembly (GO:0006335)2.88878405
51peptidyl-lysine trimethylation (GO:0018023)2.88100499
52peptidyl-histidine modification (GO:0018202)2.87977329
53DNA damage response, detection of DNA damage (GO:0042769)2.87193913
54translesion synthesis (GO:0019985)2.86921327
55regulation of mitotic spindle checkpoint (GO:1903504)2.84320350
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84320350
57regulation of centriole replication (GO:0046599)2.83176465
58maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81783852
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81385804
60DNA replication-independent nucleosome assembly (GO:0006336)2.80917442
61DNA replication-independent nucleosome organization (GO:0034724)2.80917442
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.79176756
63termination of RNA polymerase III transcription (GO:0006386)2.79176756
64protein localization to chromosome, centromeric region (GO:0071459)2.79071170
65DNA catabolic process, exonucleolytic (GO:0000738)2.78863296
66histone H3-K4 methylation (GO:0051568)2.78646239
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78579457
68regulation of double-strand break repair via homologous recombination (GO:0010569)2.78449564
69mitotic sister chromatid segregation (GO:0000070)2.76815343
70tRNA processing (GO:0008033)2.75995865
71DNA geometric change (GO:0032392)2.75528767
72sister chromatid segregation (GO:0000819)2.74547223
73mitochondrial respiratory chain complex assembly (GO:0033108)2.73905610
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73715617
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73338375
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73338375
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.73125238
78negative regulation of chromosome segregation (GO:0051985)2.72585909
79attachment of spindle microtubules to kinetochore (GO:0008608)2.71725129
80regulation of DNA damage checkpoint (GO:2000001)2.71656973
81DNA duplex unwinding (GO:0032508)2.71513553
82DNA deamination (GO:0045006)2.71376663
83somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69946211
84somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69946211
85isotype switching (GO:0045190)2.69946211
86regulation of telomere maintenance (GO:0032204)2.69383026
87tRNA metabolic process (GO:0006399)2.68820528
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.68506598
89NADH dehydrogenase complex assembly (GO:0010257)2.68506598
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68506598
91sister chromatid cohesion (GO:0007062)2.68197276
92cullin deneddylation (GO:0010388)2.67999443
93regulation of DNA-dependent DNA replication (GO:0090329)2.67000801
94non-recombinational repair (GO:0000726)2.66706621
95double-strand break repair via nonhomologous end joining (GO:0006303)2.66706621
96establishment of chromosome localization (GO:0051303)2.65943855
97rRNA modification (GO:0000154)2.65840488
98histone mRNA metabolic process (GO:0008334)2.64942553
99protein complex biogenesis (GO:0070271)2.64583454
100IMP biosynthetic process (GO:0006188)2.64197500
101histone exchange (GO:0043486)2.63994423
102negative regulation of DNA recombination (GO:0045910)2.62408770
103reciprocal meiotic recombination (GO:0007131)2.61499183
104reciprocal DNA recombination (GO:0035825)2.61499183
105DNA unwinding involved in DNA replication (GO:0006268)2.61395673
106histone H3-K9 modification (GO:0061647)2.59812915
107spindle checkpoint (GO:0031577)2.58834984
108DNA synthesis involved in DNA repair (GO:0000731)2.58657760
109pre-miRNA processing (GO:0031054)2.58247379
110DNA replication checkpoint (GO:0000076)2.57814448
111somatic hypermutation of immunoglobulin genes (GO:0016446)2.56367921
112somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56367921
113telomere maintenance via semi-conservative replication (GO:0032201)2.55280363
114RNA-dependent DNA replication (GO:0006278)2.55209041
115positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54918951
116positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54918951
117positive regulation of mitotic sister chromatid separation (GO:1901970)2.54918951
118positive regulation of chromosome segregation (GO:0051984)2.54669913
119regulation of posttranscriptional gene silencing (GO:0060147)2.54530111
120regulation of gene silencing by miRNA (GO:0060964)2.54530111
121regulation of gene silencing by RNA (GO:0060966)2.54530111
122mitotic recombination (GO:0006312)2.53726975
123regulation of mitotic sister chromatid separation (GO:0010965)2.52011760
124regulation of mitotic sister chromatid segregation (GO:0033047)2.52011760
125regulation of sister chromatid segregation (GO:0033045)2.52011760
126determination of adult lifespan (GO:0008340)2.51929064
127DNA ligation (GO:0006266)2.51413084
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51171718
129telomere maintenance via telomere lengthening (GO:0010833)2.50724372
130replication fork processing (GO:0031297)2.48815337
131negative regulation of histone methylation (GO:0031061)2.47877877
132DNA strand elongation involved in DNA replication (GO:0006271)2.47287664
133mitotic nuclear envelope disassembly (GO:0007077)2.46242228
134centriole assembly (GO:0098534)2.45427535
135telomere maintenance via recombination (GO:0000722)2.45364017
136mitotic spindle checkpoint (GO:0071174)2.45295937
137regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45247984
138regulation of histone methylation (GO:0031060)2.44708884
139telomere maintenance (GO:0000723)2.44364906
140DNA strand elongation (GO:0022616)2.43710029
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43652526
142positive regulation of histone H3-K4 methylation (GO:0051571)2.43485125
143spindle assembly checkpoint (GO:0071173)2.43037244
144histone H4-K12 acetylation (GO:0043983)2.43024177
145intra-S DNA damage checkpoint (GO:0031573)2.42639524
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41977040
147negative regulation of sister chromatid segregation (GO:0033046)2.41977040
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.41977040
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41977040
150regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.41710912
151regulation of centrosome cycle (GO:0046605)2.41639452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.65088273
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82606889
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.67616100
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.55564617
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.02834543
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.84277660
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.81507789
8GBX2_23144817_ChIP-Seq_PC3_Human2.80830594
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75922114
10ZNF274_21170338_ChIP-Seq_K562_Hela2.71188669
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.63038454
12EZH2_22144423_ChIP-Seq_EOC_Human2.52978387
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51945905
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47526500
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43346729
16* VDR_23849224_ChIP-Seq_CD4+_Human2.38142482
17* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22108985
18IGF1R_20145208_ChIP-Seq_DFB_Human2.13552961
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10659192
20* FOXP3_21729870_ChIP-Seq_TREG_Human2.08792974
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.07253396
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06376041
23FUS_26573619_Chip-Seq_HEK293_Human2.00779014
24VDR_22108803_ChIP-Seq_LS180_Human1.96070765
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93360637
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89154680
27EWS_26573619_Chip-Seq_HEK293_Human1.88731443
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86307404
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85793927
30MYC_18940864_ChIP-ChIP_HL60_Human1.84534513
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84462695
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80086860
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.79515334
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79424550
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76293482
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.75213761
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72956671
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71455940
39* MYC_18555785_ChIP-Seq_MESCs_Mouse1.69142496
40TTF2_22483619_ChIP-Seq_HELA_Human1.68576918
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68076205
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66134235
43GABP_19822575_ChIP-Seq_HepG2_Human1.64456856
44* NFE2_27457419_Chip-Seq_LIVER_Mouse1.61425179
45DCP1A_22483619_ChIP-Seq_HELA_Human1.60699253
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58799278
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58238707
48* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55845282
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55436866
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52165060
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48839399
52KDM5A_27292631_Chip-Seq_BREAST_Human1.41649086
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37632499
54* XRN2_22483619_ChIP-Seq_HELA_Human1.36976242
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36652991
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36652991
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36652991
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.36359607
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36263194
60* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35569504
61* E2F1_18555785_Chip-Seq_ESCs_Mouse1.34996958
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34577483
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33254220
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30606493
65* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30259070
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30103492
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.28007087
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25065293
69* EZH2_27294783_Chip-Seq_NPCs_Mouse1.24284036
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22780935
71* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22115464
72* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21438745
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21190477
74* P53_22387025_ChIP-Seq_ESCs_Mouse1.20488572
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19519288
76* P300_18555785_Chip-Seq_ESCs_Mouse1.19332293
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17348720
78* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17321471
79ELK1_19687146_ChIP-ChIP_HELA_Human1.17023515
80* CMYC_18555785_Chip-Seq_ESCs_Mouse1.16789109
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.16622279
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15902768
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14874901
84* STAT3_18555785_Chip-Seq_ESCs_Mouse1.13807955
85TP53_22573176_ChIP-Seq_HFKS_Human1.12723922
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10965094
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10581118
88P300_19829295_ChIP-Seq_ESCs_Human1.10363681
89* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10320307
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10116841
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10088004
92* OCT4_18555785_Chip-Seq_ESCs_Mouse1.09845339
93ER_23166858_ChIP-Seq_MCF-7_Human1.09442478
94* NMYC_18555785_Chip-Seq_ESCs_Mouse1.08615050
95* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08363491
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07981587
97TAF15_26573619_Chip-Seq_HEK293_Human1.07547194
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06043873
99* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05509211
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04349323
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03596375
102* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02358512
103RNF2_27304074_Chip-Seq_NSC_Mouse1.01722189
104* EST1_17652178_ChIP-ChIP_JURKAT_Human1.01684312
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01511198
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01511198
107MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00759108
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00517250
109* SOX2_18555785_Chip-Seq_ESCs_Mouse0.99321140
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99266928
111SOX9_26525672_Chip-Seq_HEART_Mouse0.98943918
112CIITA_25753668_ChIP-Seq_RAJI_Human0.98328500
113CBX2_27304074_Chip-Seq_ESCs_Mouse0.97492379
114CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97301770
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.96751101
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96405033
117* KLF4_18555785_Chip-Seq_ESCs_Mouse0.95803747
118IRF1_19129219_ChIP-ChIP_H3396_Human0.95637910
119* ZFX_18555785_Chip-Seq_ESCs_Mouse0.95477559
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.94254162
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93470467
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93411573
123* STAT3_23295773_ChIP-Seq_U87_Human0.93232460
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93163748
125* NANOG_16153702_ChIP-ChIP_HESCs_Human0.92812897
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91854156
127AR_21909140_ChIP-Seq_LNCAP_Human0.90973315
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90349456
129TP53_16413492_ChIP-PET_HCT116_Human0.90282081
130TCF4_23295773_ChIP-Seq_U87_Human0.89486295
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.89253065
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89222938
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89216021
134NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88374531
135* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87850231
136* CTCF_18555785_Chip-Seq_ESCs_Mouse0.87279591
137* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.87199831
138* PU1_27457419_Chip-Seq_LIVER_Mouse0.87181490
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85664077
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84599736
141CBP_20019798_ChIP-Seq_JUKART_Human0.84599736
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81263935
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79324754
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79192683
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76950931
146ELK1_22589737_ChIP-Seq_MCF10A_Human0.75903329
147NANOG_19829295_ChIP-Seq_ESCs_Human0.75589181
148SOX2_19829295_ChIP-Seq_ESCs_Human0.75589181
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.74284037
150HOXB7_26014856_ChIP-Seq_BT474_Human0.73684271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.51266663
2MP0008057_abnormal_DNA_replication3.48974052
3MP0003787_abnormal_imprinting3.47885445
4MP0003111_abnormal_nucleus_morphology3.40711510
5MP0008058_abnormal_DNA_repair3.08267296
6MP0008877_abnormal_DNA_methylation2.93462159
7MP0006292_abnormal_olfactory_placode2.79307601
8MP0003136_yellow_coat_color2.65464113
9MP0001188_hyperpigmentation2.61572773
10MP0003121_genomic_imprinting2.49569932
11MP0003693_abnormal_embryo_hatching2.47472087
12MP0003077_abnormal_cell_cycle2.40447903
13MP0009697_abnormal_copulation2.37434248
14MP0002102_abnormal_ear_morphology2.05516338
15MP0000566_synostosis2.00572273
16MP0003123_paternal_imprinting1.99277470
17MP0002837_dystrophic_cardiac_calcinosis1.94357564
18MP0000569_abnormal_digit_pigmentation1.88791538
19MP0004957_abnormal_blastocyst_morpholog1.83651673
20MP0005171_absent_coat_pigmentation1.77816979
21MP0003941_abnormal_skin_development1.77397204
22MP0003786_premature_aging1.76173485
23MP0001529_abnormal_vocalization1.75432752
24MP0008007_abnormal_cellular_replicative1.64862046
25MP0006035_abnormal_mitochondrial_morpho1.64232639
26MP0008932_abnormal_embryonic_tissue1.64038175
27MP0003880_abnormal_central_pattern1.60793562
28MP0005409_darkened_coat_color1.53281328
29MP0002396_abnormal_hematopoietic_system1.51909904
30MP0008789_abnormal_olfactory_epithelium1.51905761
31MP0000427_abnormal_hair_cycle1.43241290
32MP0003890_abnormal_embryonic-extraembry1.39000870
33MP0000015_abnormal_ear_pigmentation1.38231143
34MP0010307_abnormal_tumor_latency1.36707956
35MP0003937_abnormal_limbs/digits/tail_de1.36525144
36MP0004147_increased_porphyrin_level1.29455890
37MP0005551_abnormal_eye_electrophysiolog1.29303462
38MP0005253_abnormal_eye_physiology1.28341528
39MP0002638_abnormal_pupillary_reflex1.27085382
40MP0001486_abnormal_startle_reflex1.24712764
41MP0000647_abnormal_sebaceous_gland1.24152372
42MP0000350_abnormal_cell_proliferation1.23061660
43MP0003806_abnormal_nucleotide_metabolis1.21020089
44MP0003567_abnormal_fetal_cardiomyocyte1.18810164
45MP0004133_heterotaxia1.18639118
46MP0001293_anophthalmia1.16807451
47MP0005187_abnormal_penis_morphology1.13366951
48MP0005394_taste/olfaction_phenotype1.12251701
49MP0005499_abnormal_olfactory_system1.12251701
50MP0005174_abnormal_tail_pigmentation1.09453895
51MP0009046_muscle_twitch1.07705568
52MP0000372_irregular_coat_pigmentation1.05989485
53MP0002210_abnormal_sex_determination1.04850011
54MP0000049_abnormal_middle_ear1.04382611
55MP0003186_abnormal_redox_activity1.04078102
56MP0002938_white_spotting1.03771466
57MP0001286_abnormal_eye_development1.03409504
58MP0002277_abnormal_respiratory_mucosa1.03297626
59MP0000653_abnormal_sex_gland1.03259256
60MP0002735_abnormal_chemical_nociception1.02881533
61MP0000432_abnormal_head_morphology1.02800457
62MP0000383_abnormal_hair_follicle1.02429612
63MP0003315_abnormal_perineum_morphology1.01898646
64MP0003646_muscle_fatigue1.01155103
65MP0004742_abnormal_vestibular_system1.00064910
66MP0005389_reproductive_system_phenotype0.99602404
67MP0001697_abnormal_embryo_size0.99556005
68MP0008875_abnormal_xenobiotic_pharmacok0.98319993
69MP0001485_abnormal_pinna_reflex0.98236463
70MP0000778_abnormal_nervous_system0.98191789
71MP0000358_abnormal_cell_content/0.97877461
72MP0006036_abnormal_mitochondrial_physio0.97796641
73MP0002254_reproductive_system_inflammat0.97458715
74MP0003861_abnormal_nervous_system0.97434148
75MP0001672_abnormal_embryogenesis/_devel0.97056480
76MP0005380_embryogenesis_phenotype0.97056480
77MP0002249_abnormal_larynx_morphology0.96655707
78MP0005075_abnormal_melanosome_morpholog0.96310735
79MP0003195_calcinosis0.96245132
80MP0002095_abnormal_skin_pigmentation0.95796094
81MP0003755_abnormal_palate_morphology0.95613274
82MP0002085_abnormal_embryonic_tissue0.95426076
83MP0002751_abnormal_autonomic_nervous0.95038700
84MP0003938_abnormal_ear_development0.94945172
85MP0005646_abnormal_pituitary_gland0.94551284
86MP0002234_abnormal_pharynx_morphology0.93327824
87MP0001968_abnormal_touch/_nociception0.93084217
88MP0005423_abnormal_somatic_nervous0.92168756
89MP0005645_abnormal_hypothalamus_physiol0.91634977
90MP0004197_abnormal_fetal_growth/weight/0.91617506
91MP0005084_abnormal_gallbladder_morpholo0.90746312
92MP0004859_abnormal_synaptic_plasticity0.90628634
93MP0008995_early_reproductive_senescence0.89581781
94MP0005391_vision/eye_phenotype0.89516950
95MP0002084_abnormal_developmental_patter0.88848771
96MP0002736_abnormal_nociception_after0.88191177
97MP0009703_decreased_birth_body0.87677056
98MP0005395_other_phenotype0.86457639
99MP0002009_preneoplasia0.86231244
100MP0002163_abnormal_gland_morphology0.86014603
101MP0009745_abnormal_behavioral_response0.85959789
102MP0006276_abnormal_autonomic_nervous0.85360439
103MP0008872_abnormal_physiological_respon0.84928882
104MP0000026_abnormal_inner_ear0.83790050
105MP0004142_abnormal_muscle_tone0.83525846
106MP0003122_maternal_imprinting0.83220698
107MP0002876_abnormal_thyroid_physiology0.82960141
108MP0004808_abnormal_hematopoietic_stem0.81549985
109MP0001919_abnormal_reproductive_system0.81077290
110MP0004381_abnormal_hair_follicle0.79922205
111MP0003718_maternal_effect0.79405794
112MP0001119_abnormal_female_reproductive0.79213409
113MP0002075_abnormal_coat/hair_pigmentati0.79021944
114MP0001186_pigmentation_phenotype0.78436236
115MP0000631_abnormal_neuroendocrine_gland0.78307511
116MP0003935_abnormal_craniofacial_develop0.77904776
117MP0002116_abnormal_craniofacial_bone0.77678097
118MP0002114_abnormal_axial_skeleton0.77465304
119MP0002111_abnormal_tail_morphology0.76175021
120MP0002067_abnormal_sensory_capabilities0.75073901
121MP0001145_abnormal_male_reproductive0.74887881
122MP0006072_abnormal_retinal_apoptosis0.73948435
123MP0005623_abnormal_meninges_morphology0.73523153
124MP0000313_abnormal_cell_death0.73064897
125MP0002177_abnormal_outer_ear0.72891401
126MP0001963_abnormal_hearing_physiology0.72115889
127MP0001346_abnormal_lacrimal_gland0.71563184
128MP0001929_abnormal_gametogenesis0.71368328
129MP0001986_abnormal_taste_sensitivity0.71304220
130MP0000703_abnormal_thymus_morphology0.71235996
131MP0005195_abnormal_posterior_eye0.70981903
132MP0002233_abnormal_nose_morphology0.70940781
133MP0000428_abnormal_craniofacial_morphol0.70231270
134MP0003698_abnormal_male_reproductive0.70026535
135MP0002572_abnormal_emotion/affect_behav0.69896880
136MP0002160_abnormal_reproductive_system0.69822827
137MP0002697_abnormal_eye_size0.69295780
138MP0003984_embryonic_growth_retardation0.69221979
139MP0000490_abnormal_crypts_of0.67403461
140MP0002088_abnormal_embryonic_growth/wei0.67009809
141MP0001730_embryonic_growth_arrest0.66735962

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.47502587
2Chromsome breakage (HP:0040012)5.22243159
3Pancreatic cysts (HP:0001737)3.61452387
4Pancreatic fibrosis (HP:0100732)3.56250041
5Abnormality of midbrain morphology (HP:0002418)3.38367009
6Molar tooth sign on MRI (HP:0002419)3.38367009
7True hermaphroditism (HP:0010459)3.22397094
8Duplicated collecting system (HP:0000081)3.17799137
9Birth length less than 3rd percentile (HP:0003561)3.04753794
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.03543983
11Abnormality of chromosome stability (HP:0003220)3.01207133
12Abnormality of the preputium (HP:0100587)3.00968010
13Meckel diverticulum (HP:0002245)3.00131521
14Nephronophthisis (HP:0000090)2.97801862
15Ectopic kidney (HP:0000086)2.96000421
16Abnormality of the labia minora (HP:0012880)2.95362960
17Abnormality of the renal collecting system (HP:0004742)2.88506141
18Abnormality of DNA repair (HP:0003254)2.87079062
19Abnormality of the ileum (HP:0001549)2.84445021
20Volvulus (HP:0002580)2.76547830
21Colon cancer (HP:0003003)2.68587541
22Acute necrotizing encephalopathy (HP:0006965)2.64075036
23Nephroblastoma (Wilms tumor) (HP:0002667)2.61371727
24Medulloblastoma (HP:0002885)2.58713294
25Sclerocornea (HP:0000647)2.55699500
26Acute encephalopathy (HP:0006846)2.55658758
27Embryonal renal neoplasm (HP:0011794)2.47385548
28Bile duct proliferation (HP:0001408)2.45947880
29Abnormal biliary tract physiology (HP:0012439)2.45947880
30Abnormality of the renal medulla (HP:0100957)2.44263726
31Absent radius (HP:0003974)2.43442296
32Supernumerary spleens (HP:0009799)2.41540180
33Increased CSF lactate (HP:0002490)2.39803069
34Aplasia involving forearm bones (HP:0009822)2.35771614
35Absent forearm bone (HP:0003953)2.35771614
36Clubbing of toes (HP:0100760)2.35538547
37Duodenal stenosis (HP:0100867)2.35519173
38Small intestinal stenosis (HP:0012848)2.35519173
39Abnormality of the renal cortex (HP:0011035)2.32486670
40Abnormal mitochondria in muscle tissue (HP:0008316)2.28317999
41Anal stenosis (HP:0002025)2.26739775
42Type II lissencephaly (HP:0007260)2.26315017
43Optic nerve coloboma (HP:0000588)2.25097694
44Lipid accumulation in hepatocytes (HP:0006561)2.23991290
45Septo-optic dysplasia (HP:0100842)2.23041596
46Oligodactyly (hands) (HP:0001180)2.21871038
47Medial flaring of the eyebrow (HP:0010747)2.21738895
48Mitochondrial inheritance (HP:0001427)2.21171840
49Methylmalonic acidemia (HP:0002912)2.20564717
50Hypoplasia of the pons (HP:0012110)2.19647789
51Progressive macrocephaly (HP:0004481)2.19229581
52Agnosia (HP:0010524)2.18270363
53Supernumerary bones of the axial skeleton (HP:0009144)2.12948315
54Abnormality of the pons (HP:0007361)2.12270110
55Abnormality of the carotid arteries (HP:0005344)2.11405482
56Pendular nystagmus (HP:0012043)2.11144735
57Supernumerary ribs (HP:0005815)2.10756304
58Cerebellar dysplasia (HP:0007033)2.08823671
59Postaxial foot polydactyly (HP:0001830)2.08540326
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.08460064
61Anencephaly (HP:0002323)2.07429349
62Abnormal number of incisors (HP:0011064)2.07313988
63Febrile seizures (HP:0002373)2.06999559
64Renal cortical cysts (HP:0000803)2.06354533
65Abnormality of the nasal septum (HP:0000419)2.06298777
66Patellar aplasia (HP:0006443)2.06206499
67Increased hepatocellular lipid droplets (HP:0006565)2.05947363
68Short thumb (HP:0009778)2.05089438
69Duplication of thumb phalanx (HP:0009942)2.04854275
70Prostate neoplasm (HP:0100787)2.03908057
71Cerebral edema (HP:0002181)2.02974029
72Aplasia cutis congenita (HP:0001057)2.02418542
73Impulsivity (HP:0100710)2.01388153
74Chronic hepatic failure (HP:0100626)1.98595492
75Hyperglycinemia (HP:0002154)1.97831616
76Abnormality of the duodenum (HP:0002246)1.97803648
77Abnormality of the incisor (HP:0000676)1.97107116
78Myelodysplasia (HP:0002863)1.96938869
79Cystic liver disease (HP:0006706)1.95794401
80Increased serum lactate (HP:0002151)1.95603149
81Lip pit (HP:0100267)1.94170547
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93874245
83Abnormality of alanine metabolism (HP:0010916)1.93874245
84Hyperalaninemia (HP:0003348)1.93874245
85Retinal dysplasia (HP:0007973)1.92992441
86Neoplasm of the oral cavity (HP:0100649)1.92938385
87Aplasia/Hypoplasia of the patella (HP:0006498)1.92602801
88Intestinal atresia (HP:0011100)1.91810228
89Sloping forehead (HP:0000340)1.91094211
90Gastroesophageal reflux (HP:0002020)1.90886446
91Male pseudohermaphroditism (HP:0000037)1.90328055
92Neoplasm of the adrenal cortex (HP:0100641)1.89675328
93Lissencephaly (HP:0001339)1.88579224
94Dandy-Walker malformation (HP:0001305)1.88267378
95Acute lymphatic leukemia (HP:0006721)1.87896068
96Triphalangeal thumb (HP:0001199)1.87764211
97Hyperglycinuria (HP:0003108)1.86146576
98Abnormal lung lobation (HP:0002101)1.86077814
99Furrowed tongue (HP:0000221)1.86010827
100Neoplasm of the adrenal gland (HP:0100631)1.85983866
101Deep philtrum (HP:0002002)1.85652913
102Congenital primary aphakia (HP:0007707)1.84739536
103Type I transferrin isoform profile (HP:0003642)1.83862265
104Glioma (HP:0009733)1.83860067
105Abnormality of the antihelix (HP:0009738)1.81661599
106Esophageal atresia (HP:0002032)1.81574634
107Bone marrow hypocellularity (HP:0005528)1.81467783
108Methylmalonic aciduria (HP:0012120)1.81422908
109Asplenia (HP:0001746)1.81148087
110Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80482637
111Intestinal fistula (HP:0100819)1.79132700
112Abnormal hair whorl (HP:0010721)1.78465808
113Gastrointestinal atresia (HP:0002589)1.77209056
114Gait imbalance (HP:0002141)1.76937518
115Abnormality of the fingertips (HP:0001211)1.76890110
116Postaxial hand polydactyly (HP:0001162)1.75924761
117Upper limb muscle weakness (HP:0003484)1.75516747
118Hepatocellular necrosis (HP:0001404)1.75362339
119Ependymoma (HP:0002888)1.75293087
120Absent frontal sinuses (HP:0002688)1.74915244
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.74346612
122Cupped ear (HP:0000378)1.74189774
123Bifid tongue (HP:0010297)1.73754843
124Oligodactyly (HP:0012165)1.71165938
125Abnormality of serine family amino acid metabolism (HP:0010894)1.70789828
126Abnormality of glycine metabolism (HP:0010895)1.70789828
127Breast hypoplasia (HP:0003187)1.70187680
128Nephrogenic diabetes insipidus (HP:0009806)1.70177556
129Abnormal protein glycosylation (HP:0012346)1.69715240
130Abnormal glycosylation (HP:0012345)1.69715240
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69715240
132Abnormal protein N-linked glycosylation (HP:0012347)1.69715240
133Abnormal rod and cone electroretinograms (HP:0008323)1.69515391
134Occipital encephalocele (HP:0002085)1.68839526
135Anal atresia (HP:0002023)1.68551039
136Pancytopenia (HP:0001876)1.68531029
137Preaxial hand polydactyly (HP:0001177)1.68453952
138Abnormality of incisor morphology (HP:0011063)1.68371228
139Abnormality of chromosome segregation (HP:0002916)1.66382667
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.63820421
141Premature graying of hair (HP:0002216)1.62713617
142Absent thumb (HP:0009777)1.61948665
143Long eyelashes (HP:0000527)1.59374714
144Microtia (HP:0008551)1.59288942
145Anophthalmia (HP:0000528)1.58756272
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.57668472
147Protruding tongue (HP:0010808)1.57392771
148Abnormality of the columella (HP:0009929)1.57155725
149Trigonocephaly (HP:0000243)1.56187885
150Skull defect (HP:0001362)1.55568622
151Small hand (HP:0200055)1.54353002
152Reticulocytopenia (HP:0001896)1.53504287
153Abnormality of the astrocytes (HP:0100707)1.52546480
154Astrocytoma (HP:0009592)1.52546480
155Short 4th metacarpal (HP:0010044)1.52439950
156Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.52439950
157Mesomelia (HP:0003027)1.52402132
158Abnormality of the septum pellucidum (HP:0007375)1.52333886
159Rectal fistula (HP:0100590)1.51926708
160Rectovaginal fistula (HP:0000143)1.51926708
161Optic nerve hypoplasia (HP:0000609)1.51838297
162Astigmatism (HP:0000483)1.50330540
163Tracheoesophageal fistula (HP:0002575)1.49328585
164Cleft eyelid (HP:0000625)1.48456457
165Horseshoe kidney (HP:0000085)1.47705386
166Urethral obstruction (HP:0000796)1.47520349
167Absent septum pellucidum (HP:0001331)1.47144416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK23.71629868
2CDK123.14929640
3CDC73.10533572
4MKNK13.10232572
5SRPK12.97622280
6NEK12.78823968
7CASK2.74930669
8FRK2.69817520
9BRD42.68491122
10WNK32.65552690
11ZAK2.57779862
12VRK22.53428882
13MAP4K22.25290669
14TRIM282.11231079
15PNCK1.97016211
16BRSK21.91786939
17AKT31.90149693
18TTK1.84855867
19EIF2AK21.82152452
20ATR1.73302962
21BUB11.69143985
22TNIK1.68580391
23YES11.67418207
24MAP2K71.66572703
25PLK31.66189498
26NTRK31.64379810
27TSSK61.62830807
28TAF11.60849680
29PLK41.57524544
30MAP3K41.48370300
31WNK41.47744232
32NME11.46912322
33TLK11.44995727
34CHEK21.43905066
35EPHA21.42457682
36NEK21.35392262
37WEE11.35102668
38STK161.30690404
39PLK11.28862294
40CDK71.27442386
41NEK61.26915998
42PRPF4B1.26790402
43CHEK11.20296321
44CDK31.15658899
45ATM1.15133429
46TXK1.15048757
47NUAK11.14844257
48INSRR1.14723048
49EPHA41.10640998
50PLK21.10195131
51STK41.09296183
52DYRK21.07698262
53CLK11.07226201
54MAP3K141.04603016
55CSNK1G11.03499899
56SGK21.02667281
57CSNK1G31.02292490
58PDK21.01927733
59SIK20.99399335
60AURKB0.97290940
61BLK0.97234644
62VRK10.95518859
63BMPR20.89935629
64CDK40.89338972
65STK390.87543041
66CSNK1G20.87139599
67CDK20.86087326
68CDK10.86003244
69MST40.84976013
70OXSR10.84155000
71ALK0.83776921
72EIF2AK10.79878893
73MAPK130.71969287
74LATS10.70797681
75PRKDC0.68841979
76ACVR1B0.67764651
77DYRK1A0.67431257
78EIF2AK30.65914894
79MELK0.65268269
80MAPK140.63043471
81BRSK10.62953331
82GSK3B0.61718800
83CSNK1E0.61599858
84STK30.61473310
85PINK10.60836459
86GRK10.60557904
87CDK90.60343946
88CSNK1D0.59965459
89PIM20.59518694
90ERBB30.58728313
91PASK0.58547698
92SGK10.58411458
93PIM10.57868547
94RPS6KA40.57445731
95CDK80.56237535
96PAK30.55851523
97CDK60.55656245
98STK38L0.55653961
99CAMK1G0.55549963
100DYRK30.55525509
101MAPK100.54671444
102MAP3K60.54651969
103ADRBK20.54296267
104TEC0.53420079
105BMPR1B0.52680983
106SGK30.52044000
107SIK30.51879194
108RPS6KA50.51869079
109PKN10.51494265
110BCKDK0.50692131
111CCNB10.49443898
112CAMK1D0.48581296
113PBK0.48478308
114IRAK10.46540822
115IRAK40.46121470
116RPS6KB10.45625415
117CSNK2A20.45469942
118BRAF0.44500739
119MAPKAPK50.43923815
120AKT10.42234862
121CSNK2A10.42137715
122IRAK30.41972524
123PRKCI0.41895703
124MAP2K60.41843793
125CSNK1A1L0.41598451
126AKT20.40624610
127MAPK80.39696732
128FGFR20.39505493
129PRKCE0.39322256
130SGK2230.38519117
131SGK4940.38519117
132AURKA0.37891140
133RPS6KB20.37064886
134FES0.36816905
135BCR0.36139932
136RAF10.36025563
137TGFBR10.35476563
138CSNK1A10.33875559
139MINK10.32875700
140PRKCG0.30662121

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.12652739
2Fanconi anemia pathway_Homo sapiens_hsa034603.07642307
3DNA replication_Homo sapiens_hsa030302.99107848
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76702776
5Homologous recombination_Homo sapiens_hsa034402.76094095
6Proteasome_Homo sapiens_hsa030502.73724471
7Protein export_Homo sapiens_hsa030602.57986923
8Oxidative phosphorylation_Homo sapiens_hsa001902.38090977
9Non-homologous end-joining_Homo sapiens_hsa034502.37349871
10Spliceosome_Homo sapiens_hsa030402.34863454
11Nucleotide excision repair_Homo sapiens_hsa034202.23305385
12Parkinsons disease_Homo sapiens_hsa050122.13645442
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13172658
14Cell cycle_Homo sapiens_hsa041102.09516427
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05902958
16RNA transport_Homo sapiens_hsa030132.05232921
17mRNA surveillance pathway_Homo sapiens_hsa030152.00525412
18Base excision repair_Homo sapiens_hsa034101.95549260
19Nicotine addiction_Homo sapiens_hsa050331.94615371
20Basal transcription factors_Homo sapiens_hsa030221.85499287
21One carbon pool by folate_Homo sapiens_hsa006701.82917346
22Propanoate metabolism_Homo sapiens_hsa006401.81085211
23RNA polymerase_Homo sapiens_hsa030201.80094135
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77834742
25Huntingtons disease_Homo sapiens_hsa050161.67831552
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59057810
27Selenocompound metabolism_Homo sapiens_hsa004501.56261818
28Butanoate metabolism_Homo sapiens_hsa006501.55580209
29RNA degradation_Homo sapiens_hsa030181.53243992
30Systemic lupus erythematosus_Homo sapiens_hsa053221.47975700
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35148162
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34004237
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32914737
34Caffeine metabolism_Homo sapiens_hsa002321.25081956
35Pyruvate metabolism_Homo sapiens_hsa006201.19621448
36Alzheimers disease_Homo sapiens_hsa050101.19150190
37p53 signaling pathway_Homo sapiens_hsa041151.18595496
38Regulation of autophagy_Homo sapiens_hsa041401.18535072
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18222882
40Steroid biosynthesis_Homo sapiens_hsa001001.15190057
41Pyrimidine metabolism_Homo sapiens_hsa002401.06332521
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06155109
43Basal cell carcinoma_Homo sapiens_hsa052171.04292430
44Fatty acid elongation_Homo sapiens_hsa000621.04251591
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03677607
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01367241
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00938368
48MicroRNAs in cancer_Homo sapiens_hsa052060.99827437
49Phototransduction_Homo sapiens_hsa047440.98366929
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.95654114
51Herpes simplex infection_Homo sapiens_hsa051680.92963322
52Autoimmune thyroid disease_Homo sapiens_hsa053200.91966122
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91790415
54Taste transduction_Homo sapiens_hsa047420.91461071
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91195596
56Wnt signaling pathway_Homo sapiens_hsa043100.90370497
57Alcoholism_Homo sapiens_hsa050340.90329243
58Nitrogen metabolism_Homo sapiens_hsa009100.90054368
59Epstein-Barr virus infection_Homo sapiens_hsa051690.88040056
60Viral carcinogenesis_Homo sapiens_hsa052030.87962286
61Morphine addiction_Homo sapiens_hsa050320.84977881
62Glutamatergic synapse_Homo sapiens_hsa047240.84556363
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83585900
64Oocyte meiosis_Homo sapiens_hsa041140.83583825
65Purine metabolism_Homo sapiens_hsa002300.82567875
66Primary immunodeficiency_Homo sapiens_hsa053400.81491640
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77572883
68Sulfur relay system_Homo sapiens_hsa041220.77404743
69Tryptophan metabolism_Homo sapiens_hsa003800.77331922
70HTLV-I infection_Homo sapiens_hsa051660.77290749
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76669906
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.75943057
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74412369
74Hedgehog signaling pathway_Homo sapiens_hsa043400.73450509
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73087034
76Axon guidance_Homo sapiens_hsa043600.73005465
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71915193
78Linoleic acid metabolism_Homo sapiens_hsa005910.71633711
79Long-term depression_Homo sapiens_hsa047300.70931487
80Melanoma_Homo sapiens_hsa052180.69181144
81Long-term potentiation_Homo sapiens_hsa047200.69148069
82Metabolic pathways_Homo sapiens_hsa011000.68908083
83Measles_Homo sapiens_hsa051620.66118925
84Allograft rejection_Homo sapiens_hsa053300.65696610
85Peroxisome_Homo sapiens_hsa041460.65362950
86Serotonergic synapse_Homo sapiens_hsa047260.64402623
87Calcium signaling pathway_Homo sapiens_hsa040200.63918085
88Graft-versus-host disease_Homo sapiens_hsa053320.63553850
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63497807
90Notch signaling pathway_Homo sapiens_hsa043300.63381732
91Lysine degradation_Homo sapiens_hsa003100.62894274
92Fatty acid metabolism_Homo sapiens_hsa012120.62672328
93Cardiac muscle contraction_Homo sapiens_hsa042600.62408772
94Hippo signaling pathway_Homo sapiens_hsa043900.60537662
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59631864
96Colorectal cancer_Homo sapiens_hsa052100.59329523
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59084958
98ErbB signaling pathway_Homo sapiens_hsa040120.58760163
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58541986
100Circadian entrainment_Homo sapiens_hsa047130.58271806
101Hematopoietic cell lineage_Homo sapiens_hsa046400.58210001
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58115672
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.56721648
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56693006
105Type I diabetes mellitus_Homo sapiens_hsa049400.56088896
106TGF-beta signaling pathway_Homo sapiens_hsa043500.55965297
107Inositol phosphate metabolism_Homo sapiens_hsa005620.54519294
108Amphetamine addiction_Homo sapiens_hsa050310.53916455
109MAPK signaling pathway_Homo sapiens_hsa040100.53535458
110T cell receptor signaling pathway_Homo sapiens_hsa046600.53412185
111Prostate cancer_Homo sapiens_hsa052150.53182352
112Small cell lung cancer_Homo sapiens_hsa052220.53134153
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52399807
114Pathways in cancer_Homo sapiens_hsa052000.51625462
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51436296
116Ether lipid metabolism_Homo sapiens_hsa005650.50304048
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49112369
118beta-Alanine metabolism_Homo sapiens_hsa004100.48731796
119Type II diabetes mellitus_Homo sapiens_hsa049300.48571187
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46342750
121Influenza A_Homo sapiens_hsa051640.45751208
122Folate biosynthesis_Homo sapiens_hsa007900.44642852
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44163782
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43991090
125Asthma_Homo sapiens_hsa053100.43671006
126Hepatitis B_Homo sapiens_hsa051610.43500192
127Ribosome_Homo sapiens_hsa030100.42781094
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42386456
129FoxO signaling pathway_Homo sapiens_hsa040680.41780318
130Dopaminergic synapse_Homo sapiens_hsa047280.40870931
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39749411
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39522979
133cAMP signaling pathway_Homo sapiens_hsa040240.38598047
134Ras signaling pathway_Homo sapiens_hsa040140.37957654
135Choline metabolism in cancer_Homo sapiens_hsa052310.37254832
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36756897
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36107787
138GABAergic synapse_Homo sapiens_hsa047270.35649466
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34086399
140Olfactory transduction_Homo sapiens_hsa047400.34084680
141Sphingolipid metabolism_Homo sapiens_hsa006000.33559357
142Pancreatic cancer_Homo sapiens_hsa052120.33251900
143Biosynthesis of amino acids_Homo sapiens_hsa012300.33212313
144Glutathione metabolism_Homo sapiens_hsa004800.32292506
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32088295
146Rap1 signaling pathway_Homo sapiens_hsa040150.31198635
147Vitamin B6 metabolism_Homo sapiens_hsa007500.30781143
148Arginine and proline metabolism_Homo sapiens_hsa003300.28348654
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.26485315
150Carbon metabolism_Homo sapiens_hsa012000.23630159
151Fatty acid degradation_Homo sapiens_hsa000710.22609911
152Chemical carcinogenesis_Homo sapiens_hsa052040.21977486
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20916571
1542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20493503
155Circadian rhythm_Homo sapiens_hsa047100.18598754
156Collecting duct acid secretion_Homo sapiens_hsa049660.18077807
157ABC transporters_Homo sapiens_hsa020100.17692357
158Sulfur metabolism_Homo sapiens_hsa009200.15933121
159Vitamin digestion and absorption_Homo sapiens_hsa049770.14943133
160Retinol metabolism_Homo sapiens_hsa008300.14887547

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