NWD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.42088325
2left/right pattern formation (GO:0060972)7.65207889
3regulation of cilium movement (GO:0003352)7.61256334
4left/right axis specification (GO:0070986)6.60669350
5primary alcohol catabolic process (GO:0034310)6.08975519
6locomotory exploration behavior (GO:0035641)6.04220363
7L-amino acid import (GO:0043092)5.93737330
8cilium organization (GO:0044782)5.91249140
9microtubule bundle formation (GO:0001578)5.91171470
10ventricular system development (GO:0021591)5.85483766
11cilium assembly (GO:0042384)5.75220346
12intraciliary transport (GO:0042073)5.72280300
13vitamin transmembrane transport (GO:0035461)5.70395775
14sodium ion export (GO:0071436)5.56196966
15cellular potassium ion homeostasis (GO:0030007)5.54755952
16diterpenoid biosynthetic process (GO:0016102)5.27938008
17one-carbon compound transport (GO:0019755)5.18854969
18ethanol metabolic process (GO:0006067)5.15754985
19protein localization to cilium (GO:0061512)5.12604631
20amino acid import (GO:0043090)5.05453914
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.93749755
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.88547819
23synaptic vesicle maturation (GO:0016188)4.85655394
24response to xenobiotic stimulus (GO:0009410)4.84579829
25regulation of microtubule-based movement (GO:0060632)4.80367875
26gamma-aminobutyric acid transport (GO:0015812)4.77057845
27neurotransmitter-gated ion channel clustering (GO:0072578)4.71637658
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64671023
29cellular component assembly involved in morphogenesis (GO:0010927)4.59832873
30cilium morphogenesis (GO:0060271)4.58215779
31vocalization behavior (GO:0071625)4.55294572
32ionotropic glutamate receptor signaling pathway (GO:0035235)4.54044999
33negative regulation of T cell differentiation in thymus (GO:0033085)4.51604552
34centriole assembly (GO:0098534)4.48863918
35C4-dicarboxylate transport (GO:0015740)4.47114901
36positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.42210607
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.40517069
38alanine transport (GO:0032328)4.39376192
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.36848344
40glutamate receptor signaling pathway (GO:0007215)4.34516158
41regulation of glutamate receptor signaling pathway (GO:1900449)4.33001447
42lung epithelium development (GO:0060428)4.28534873
43synaptic vesicle docking involved in exocytosis (GO:0016081)4.26720720
44microtubule-based movement (GO:0007018)4.24183828
45synaptic vesicle exocytosis (GO:0016079)4.23580068
46pyrimidine-containing compound transmembrane transport (GO:0072531)4.22496688
47tolerance induction (GO:0002507)4.22243788
48potassium ion import (GO:0010107)4.22077676
49synaptic transmission, glutamatergic (GO:0035249)4.16782301
50glutamate secretion (GO:0014047)4.13268023
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.11695571
52cell communication by electrical coupling (GO:0010644)4.10831054
53response to auditory stimulus (GO:0010996)4.10695789
54regulation of synapse structural plasticity (GO:0051823)4.07579073
55cell projection assembly (GO:0030031)4.03408883
56regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01879557
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.01293150
58regulation of interleukin-5 production (GO:0032674)3.99289277
59retinoic acid metabolic process (GO:0042573)3.97435901
60sperm capacitation (GO:0048240)3.96128697
61regulation of neuronal synaptic plasticity (GO:0048168)3.94871474
62establishment of apical/basal cell polarity (GO:0035089)3.94303137
63terpenoid biosynthetic process (GO:0016114)3.93585424
64postsynaptic membrane organization (GO:0001941)3.93517473
65exploration behavior (GO:0035640)3.91231546
66ethanol oxidation (GO:0006069)3.89189282
67negative regulation of B cell mediated immunity (GO:0002713)3.87506226
68negative regulation of immunoglobulin mediated immune response (GO:0002890)3.87506226
69auditory behavior (GO:0031223)3.84852095
70cerebellar granule cell differentiation (GO:0021707)3.83473686
71cellular sodium ion homeostasis (GO:0006883)3.79541618
72neuron cell-cell adhesion (GO:0007158)3.77459513
73long-term memory (GO:0007616)3.76661507
74potassium ion homeostasis (GO:0055075)3.75804988
75proline transport (GO:0015824)3.74130854
76neurotransmitter secretion (GO:0007269)3.71594164
77glomerular epithelial cell development (GO:0072310)3.71026195
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69063535
79establishment or maintenance of monopolar cell polarity (GO:0061339)3.67665039
80establishment of monopolar cell polarity (GO:0061162)3.67665039
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67364315
82regulation of interleukin-13 production (GO:0032656)3.66327344
83regulation of synaptic vesicle exocytosis (GO:2000300)3.63808206
84neuronal action potential propagation (GO:0019227)3.61441336
85exogenous drug catabolic process (GO:0042738)3.57642636
86negative regulation of humoral immune response (GO:0002921)3.56264570
87regulation of germinal center formation (GO:0002634)3.56240597
88lateral ventricle development (GO:0021670)3.56181252
89neurotransmitter uptake (GO:0001504)3.55902326
90negative regulation of astrocyte differentiation (GO:0048712)3.51340910
91response to histamine (GO:0034776)3.50011760
92neuron-neuron synaptic transmission (GO:0007270)3.48257169
93cytoplasmic microtubule organization (GO:0031122)3.48072420
94protein localization to synapse (GO:0035418)3.46574138
95layer formation in cerebral cortex (GO:0021819)3.45594875
96microtubule polymerization or depolymerization (GO:0031109)3.44304044
97dendrite morphogenesis (GO:0048813)3.44292432
98regulation of synaptic transmission, glutamatergic (GO:0051966)3.43588528
99nucleoside diphosphate phosphorylation (GO:0006165)3.43508026
100ovulation cycle (GO:0042698)3.40347686
101acidic amino acid transport (GO:0015800)3.38539649
102cerebellar Purkinje cell differentiation (GO:0021702)3.35076964
103sperm motility (GO:0030317)3.34074164
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.29864914
105regulation of synaptic vesicle transport (GO:1902803)3.26771802
106positive regulation of potassium ion transmembrane transport (GO:1901381)3.26534003
107positive regulation of membrane potential (GO:0045838)3.24551421
108negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23203477
109regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21721085
110prepulse inhibition (GO:0060134)3.21383521
111microtubule depolymerization (GO:0007019)3.19924867
112transmission of nerve impulse (GO:0019226)3.18743344
113negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17232091
114chondroitin sulfate catabolic process (GO:0030207)3.15910659
115establishment of nucleus localization (GO:0040023)3.15318113
116retinol metabolic process (GO:0042572)3.15231757
117neurotransmitter transport (GO:0006836)3.14958590
118determination of left/right symmetry (GO:0007368)3.12873078
119synaptic vesicle endocytosis (GO:0048488)3.12266036
120glycine transport (GO:0015816)3.12213674
121negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.11898578
122regulation of beta-amyloid formation (GO:1902003)3.08770880
123dendritic spine morphogenesis (GO:0060997)3.08185611
124L-glutamate transport (GO:0015813)3.08134155
125regulation of synaptic plasticity (GO:0048167)3.07538915
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07154144
127regulation of neurotransmitter levels (GO:0001505)3.05657743
128mechanosensory behavior (GO:0007638)3.05329960
129nonmotile primary cilium assembly (GO:0035058)3.05300483
130long-term synaptic potentiation (GO:0060291)3.05195341
131regulation of postsynaptic membrane potential (GO:0060078)3.02858687
132innervation (GO:0060384)3.01386547
133glial cell proliferation (GO:0014009)3.00653566
134neuromuscular process controlling balance (GO:0050885)2.97296695
135drug catabolic process (GO:0042737)2.96971194
136glutathione derivative metabolic process (GO:1901685)2.96807625
137glutathione derivative biosynthetic process (GO:1901687)2.96807625
138neuromuscular synaptic transmission (GO:0007274)2.96217850
139determination of bilateral symmetry (GO:0009855)2.96114803
140primary alcohol metabolic process (GO:0034308)2.95970024
141smoothened signaling pathway (GO:0007224)2.95928647
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95303698
143presynaptic membrane assembly (GO:0097105)2.94987947
144photoreceptor cell maintenance (GO:0045494)2.93609221
145regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93529303
146regulation of ARF protein signal transduction (GO:0032012)2.93239611
147centriole replication (GO:0007099)2.92830265
148specification of symmetry (GO:0009799)2.87955358
149positive regulation of tolerance induction (GO:0002645)2.85562363
150negative regulation of inclusion body assembly (GO:0090084)2.84990882
151cell differentiation in hindbrain (GO:0021533)2.84872519
152membrane hyperpolarization (GO:0060081)2.84853119
153negative regulation of sodium ion transport (GO:0010766)2.83520033
154neuronal ion channel clustering (GO:0045161)2.83120533
155synapse assembly (GO:0007416)2.80888994
156membrane repolarization (GO:0086009)2.79071875
157positive regulation of synapse maturation (GO:0090129)2.78863562
158membrane depolarization during action potential (GO:0086010)2.77933881
159cornea development in camera-type eye (GO:0061303)2.77221408
160regulation of neurotransmitter secretion (GO:0046928)2.77161087
161visual behavior (GO:0007632)2.76663625
162retinal cone cell development (GO:0046549)2.76577876
163neuromuscular process controlling posture (GO:0050884)2.75564164
164regulation of vesicle fusion (GO:0031338)2.75291939
165O-glycan processing (GO:0016266)2.71294065
166establishment of planar polarity (GO:0001736)2.70350649
167establishment of tissue polarity (GO:0007164)2.70350649
168aldehyde catabolic process (GO:0046185)2.70248839
169regulation of collateral sprouting (GO:0048670)2.68013336
170positive regulation of smoothened signaling pathway (GO:0045880)2.67486779
171protein polyglutamylation (GO:0018095)2.66334189
172retinal rod cell development (GO:0046548)2.59516672
173iron ion import (GO:0097286)2.58639326
174microtubule-based process (GO:0007017)2.53638031
175neurotransmitter metabolic process (GO:0042133)2.53573193
176phosphatidylcholine biosynthetic process (GO:0006656)2.50641371
177organelle assembly (GO:0070925)2.50402976
178hydrogen peroxide biosynthetic process (GO:0050665)2.49681009
179excretion (GO:0007588)2.45089688
180thyroid hormone metabolic process (GO:0042403)2.42569493
181regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.40910684
182sodium ion homeostasis (GO:0055078)2.40001359
183organic cation transport (GO:0015695)2.39552850
184lateral sprouting from an epithelium (GO:0060601)2.38668468
185spinal cord motor neuron differentiation (GO:0021522)2.36660228
186sialylation (GO:0097503)2.36147943
187apical protein localization (GO:0045176)2.35888978
188carnitine metabolic process (GO:0009437)2.35773662
189regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.34677973
190calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.34310826
191neurotransmitter biosynthetic process (GO:0042136)2.33029864
192benzene-containing compound metabolic process (GO:0042537)2.32327297
193cellular ketone body metabolic process (GO:0046950)2.28986058
194phosphatidylethanolamine biosynthetic process (GO:0006646)2.28549503
195axonemal dynein complex assembly (GO:0070286)18.3806127
196cilium or flagellum-dependent cell motility (GO:0001539)16.2903738
197cilium movement (GO:0003341)14.1079840
198epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.1594495
199motile cilium assembly (GO:0044458)12.3214395
200epithelial cilium movement (GO:0003351)12.1655297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80861820
2GBX2_23144817_ChIP-Seq_PC3_Human3.46124540
3VDR_22108803_ChIP-Seq_LS180_Human2.98358670
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89936717
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87160352
6* DROSHA_22980978_ChIP-Seq_HELA_Human2.86553627
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76029946
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58673067
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.55246326
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51488338
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51488338
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46020035
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42382015
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42378517
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41839123
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.40411003
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36685496
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35609326
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32302955
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30987691
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.28793255
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.26062574
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24604846
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.23621157
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17470471
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.12204792
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08294155
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.98864341
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98155243
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96589836
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.86567053
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84784494
33* AR_21572438_ChIP-Seq_LNCaP_Human1.79586792
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78657315
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.74748370
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74395366
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62572012
38SMAD4_21799915_ChIP-Seq_A2780_Human1.58154369
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.49074396
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47320038
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43762616
42* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43666736
43TAF15_26573619_Chip-Seq_HEK293_Human1.43461999
44RXR_22108803_ChIP-Seq_LS180_Human1.40952030
45AR_25329375_ChIP-Seq_VCAP_Human1.40888436
46* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39551087
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39445097
48ER_23166858_ChIP-Seq_MCF-7_Human1.39076079
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38262101
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.37438723
51AR_19668381_ChIP-Seq_PC3_Human1.37182373
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36877456
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36678589
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36564434
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35640597
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34418532
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34394842
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.33831559
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31513868
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31295212
61P300_19829295_ChIP-Seq_ESCs_Human1.31099684
62TP53_16413492_ChIP-PET_HCT116_Human1.28905205
63* TP63_23658742_ChIP-Seq_EP156T_Human1.28579195
64ETV1_20927104_ChIP-Seq_GIST48_Human1.27940236
65TCF4_22108803_ChIP-Seq_LS180_Human1.27869573
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.27255878
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.26026101
68STAT3_23295773_ChIP-Seq_U87_Human1.24990273
69SMRT_27268052_Chip-Seq_Bcells_Human1.24698786
70* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24103123
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23937400
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23526331
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22407236
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.22283585
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21988607
76FOXA1_25552417_ChIP-Seq_VCAP_Human1.20999895
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.20295958
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20295958
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19451666
80* PIAS1_25552417_ChIP-Seq_VCAP_Human1.18739730
81CBP_20019798_ChIP-Seq_JUKART_Human1.18659354
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18659354
83STAT1_20625510_ChIP-Seq_HELA_Human1.18235330
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17390250
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17283713
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15823946
87PHF8_20622853_ChIP-Seq_HELA_Human1.15189439
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14409871
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13504964
90TCF4_23295773_ChIP-Seq_U87_Human1.13267485
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12902023
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.12497383
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12014759
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12014759
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.11667921
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11556307
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11510774
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10702826
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10403870
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.09079140
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08958870
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06974655
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06694681
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06036825
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05439945
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05189367
107* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05167615
108TBL1_22424771_ChIP-Seq_293T_Human1.05077170
109FUS_26573619_Chip-Seq_HEK293_Human1.04749820
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04286938
111BCAT_22108803_ChIP-Seq_LS180_Human1.04098225
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03823107
113CDX2_22108803_ChIP-Seq_LS180_Human1.03726173
114RBPJ_21746931_ChIP-Seq_IB4_Human1.03492129
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03376011
116* AR_20517297_ChIP-Seq_VCAP_Human1.03157643
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01965857
118HNFA_21074721_ChIP-Seq_CACO-2_Human1.01910150
119IGF1R_20145208_ChIP-Seq_DFB_Human1.01758601
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01737005
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.01684474
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01676331
123RING1B_27294783_Chip-Seq_NPCs_Mouse1.01661199
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01347116
125SMAD3_21741376_ChIP-Seq_ESCs_Human1.01298342
126NFYA_21822215_ChIP-Seq_K562_Human1.00975836
127CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00794358
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00442844
129CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00202865
130NCOR_22424771_ChIP-Seq_293T_Human0.99979215
131KDM2B_26808549_Chip-Seq_K562_Human0.99876345
132NFYB_21822215_ChIP-Seq_K562_Human0.98793345
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98725203
134WDR5_24793694_ChIP-Seq_LNCAP_Human0.97390912
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96856849
136TP53_18474530_ChIP-ChIP_U2OS_Human0.96836093
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.95530566
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.95394328
139MYC_19829295_ChIP-Seq_ESCs_Human0.95073871
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94123859
141* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93927250
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.92660733
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92328172
144AHR_22903824_ChIP-Seq_MCF-7_Human0.92213167
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92086849
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91733008
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91483047
148* RUNX2_22187159_ChIP-Seq_PCA_Human0.90720646
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88669244
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87869968
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87743049
152TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87639426
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87476132
154ZNF274_21170338_ChIP-Seq_K562_Hela0.87463434
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86625194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.98398496
2MP0008875_abnormal_xenobiotic_pharmacok5.97146738
3MP0002653_abnormal_ependyma_morphology5.25219743
4MP0004043_abnormal_pH_regulation4.10761639
5MP0003635_abnormal_synaptic_transmissio3.81323807
6MP0002132_abnormal_respiratory_system3.48981604
7MP0001486_abnormal_startle_reflex3.23763600
8MP0002277_abnormal_respiratory_mucosa3.22003078
9MP0004133_heterotaxia3.17499750
10MP0009046_muscle_twitch3.14189748
11MP0009745_abnormal_behavioral_response3.08959232
12MP0004270_analgesia3.04849288
13MP0002063_abnormal_learning/memory/cond2.95565222
14MP0002064_seizures2.90651520
15MP0005423_abnormal_somatic_nervous2.85747357
16MP0003880_abnormal_central_pattern2.85739461
17MP0005646_abnormal_pituitary_gland2.84709220
18MP0004885_abnormal_endolymph2.72095544
19MP0001984_abnormal_olfaction2.68951261
20MP0008569_lethality_at_weaning2.67381717
21MP0001968_abnormal_touch/_nociception2.66978895
22MP0002572_abnormal_emotion/affect_behav2.65587719
23MP0004858_abnormal_nervous_system2.38571555
24MP0000383_abnormal_hair_follicle2.37636222
25MP0003690_abnormal_glial_cell2.37564510
26MP0002272_abnormal_nervous_system2.37004183
27MP0002736_abnormal_nociception_after2.36975427
28MP0008789_abnormal_olfactory_epithelium2.34129828
29MP0009780_abnormal_chondrocyte_physiolo2.32176346
30MP0001502_abnormal_circadian_rhythm2.20887805
31MP0002734_abnormal_mechanical_nocicepti2.14668372
32MP0002067_abnormal_sensory_capabilities2.03305362
33MP0001440_abnormal_grooming_behavior2.00744141
34MP0001501_abnormal_sleep_pattern1.99016477
35MP0004019_abnormal_vitamin_homeostasis1.95127315
36MP0002557_abnormal_social/conspecific_i1.94249360
37MP0002876_abnormal_thyroid_physiology1.92169706
38MP0001765_abnormal_ion_homeostasis1.85674757
39MP0010678_abnormal_skin_adnexa1.78532125
40MP0003633_abnormal_nervous_system1.74946388
41MP0002733_abnormal_thermal_nociception1.71001463
42MP0005623_abnormal_meninges_morphology1.66491647
43MP0002160_abnormal_reproductive_system1.65738926
44MP0000778_abnormal_nervous_system1.65645090
45MP0002168_other_aberrant_phenotype1.64445915
46MP0003183_abnormal_peptide_metabolism1.61965939
47MP0002822_catalepsy1.59763578
48MP0001970_abnormal_pain_threshold1.58637455
49MP0004142_abnormal_muscle_tone1.54315692
50MP0002735_abnormal_chemical_nociception1.47031643
51MP0005645_abnormal_hypothalamus_physiol1.44242705
52MP0003631_nervous_system_phenotype1.42688689
53MP0000955_abnormal_spinal_cord1.39577073
54MP0004924_abnormal_behavior1.39462429
55MP0005386_behavior/neurological_phenoty1.39462429
56MP0005167_abnormal_blood-brain_barrier1.37627629
57MP0002882_abnormal_neuron_morphology1.36807814
58MP0003195_calcinosis1.36768701
59MP0001485_abnormal_pinna_reflex1.36690196
60MP0003329_amyloid_beta_deposits1.36335896
61MP0004811_abnormal_neuron_physiology1.34756516
62MP0002282_abnormal_trachea_morphology1.33294889
63MP0003634_abnormal_glial_cell1.31545807
64MP0002909_abnormal_adrenal_gland1.30997472
65MP0005636_abnormal_mineral_homeostasis1.30512679
66MP0002184_abnormal_innervation1.29475453
67MP0001188_hyperpigmentation1.27300059
68MP0005551_abnormal_eye_electrophysiolog1.26254180
69MP0006292_abnormal_olfactory_placode1.24628355
70MP0002066_abnormal_motor_capabilities/c1.22436049
71MP0003787_abnormal_imprinting1.20873455
72MP0003075_altered_response_to1.19418538
73MP0002638_abnormal_pupillary_reflex1.17658811
74MP0002152_abnormal_brain_morphology1.15314918
75MP0003632_abnormal_nervous_system1.12922534
76MP0002089_abnormal_postnatal_growth/wei1.12649519
77MP0003646_muscle_fatigue1.11467074
78MP0005395_other_phenotype1.11415824
79MP0000920_abnormal_myelination1.11084701
80MP0002090_abnormal_vision1.09975447
81MP0000566_synostosis1.00736503
82MP0008874_decreased_physiological_sensi0.99371106
83MP0005389_reproductive_system_phenotype0.98206862
84MP0005310_abnormal_salivary_gland0.97652790
85MP0001177_atelectasis0.97092621
86MP0001963_abnormal_hearing_physiology0.96869247
87MP0003656_abnormal_erythrocyte_physiolo0.96416133
88MP0002229_neurodegeneration0.95833991
89MP0000678_abnormal_parathyroid_gland0.94578706
90MP0005409_darkened_coat_color0.94017963
91MP0003698_abnormal_male_reproductive0.93538852
92MP0003879_abnormal_hair_cell0.91620857
93MP0001905_abnormal_dopamine_level0.91322960
94MP0005499_abnormal_olfactory_system0.90847286
95MP0005394_taste/olfaction_phenotype0.90847286
96MP0003137_abnormal_impulse_conducting0.89803544
97MP0003011_delayed_dark_adaptation0.89534657
98MP0005083_abnormal_biliary_tract0.87522153
99MP0000569_abnormal_digit_pigmentation0.85392488
100MP0005220_abnormal_exocrine_pancreas0.84917448
101MP0000631_abnormal_neuroendocrine_gland0.84582338
102MP0001944_abnormal_pancreas_morphology0.83897066
103MP0001664_abnormal_digestion0.82388074
104MP0001929_abnormal_gametogenesis0.82174004
105MP0000427_abnormal_hair_cycle0.81688567
106MP0005195_abnormal_posterior_eye0.81355266
107MP0004130_abnormal_muscle_cell0.80610095
108MP0001299_abnormal_eye_distance/0.80464579
109MP0002069_abnormal_eating/drinking_beha0.80454302
110MP0003045_fibrosis0.79579317
111MP0001346_abnormal_lacrimal_gland0.79074889
112MP0002928_abnormal_bile_duct0.78075475
113MP0002102_abnormal_ear_morphology0.77405394
114MP0003172_abnormal_lysosome_physiology0.76349720
115MP0003878_abnormal_ear_physiology0.76097932
116MP0005377_hearing/vestibular/ear_phenot0.76097932
117MP0002752_abnormal_somatic_nervous0.75155845
118MP0005253_abnormal_eye_physiology0.74743333
119MP0009643_abnormal_urine_homeostasis0.74528030
120MP0005085_abnormal_gallbladder_physiolo0.72918587
121MP0004215_abnormal_myocardial_fiber0.71961624
122MP0002249_abnormal_larynx_morphology0.71772021
123MP0004742_abnormal_vestibular_system0.71467967
124MP0001324_abnormal_eye_pigmentation0.69699711
125MP0001756_abnormal_urination0.69211221
126MP0002254_reproductive_system_inflammat0.69122271
127MP0002136_abnormal_kidney_physiology0.68761371
128MP0002233_abnormal_nose_morphology0.67609774
129MP0003252_abnormal_bile_duct0.66696260
130MP0000751_myopathy0.66246234
131MP0004484_altered_response_of0.65536837
132MP0003890_abnormal_embryonic-extraembry0.64363059
133MP0004085_abnormal_heartbeat0.63972818
134MP0004145_abnormal_muscle_electrophysio0.63844936
135MP0006276_abnormal_autonomic_nervous0.63794957
136MP0010769_abnormal_survival0.63041048
137MP0006072_abnormal_retinal_apoptosis0.61733959
138MP0005365_abnormal_bile_salt0.61690383
139MP0000026_abnormal_inner_ear0.60365241
140MP0003136_yellow_coat_color0.60330606
141MP0001986_abnormal_taste_sensitivity0.59901516
142MP0010768_mortality/aging0.58052180
143MP0010770_preweaning_lethality0.57840989
144MP0002082_postnatal_lethality0.57840989
145MP0001529_abnormal_vocalization0.53125212
146MP0008872_abnormal_physiological_respon0.51774833
147MP0003283_abnormal_digestive_organ0.50783084

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.46333533
2Chronic bronchitis (HP:0004469)7.31483357
3Bronchiectasis (HP:0002110)6.88730662
4Focal motor seizures (HP:0011153)6.09173199
5Nasal polyposis (HP:0100582)5.77389937
6Megalencephaly (HP:0001355)5.08690888
7Abnormality of the nasal mucosa (HP:0000433)4.70918842
8Myokymia (HP:0002411)4.65735011
9Epileptic encephalopathy (HP:0200134)4.49321049
10Aplasia involving bones of the upper limbs (HP:0009823)4.48460125
11Aplasia of the phalanges of the hand (HP:0009802)4.48460125
12Aplasia involving bones of the extremities (HP:0009825)4.48460125
13Focal seizures (HP:0007359)4.22445139
14Progressive cerebellar ataxia (HP:0002073)4.22037652
15Action tremor (HP:0002345)4.20695926
16True hermaphroditism (HP:0010459)4.04958368
17Recurrent sinusitis (HP:0011108)4.01025205
18Bronchitis (HP:0012387)4.00260458
19Infertility (HP:0000789)3.85552646
20Febrile seizures (HP:0002373)3.79588347
21Chronic sinusitis (HP:0011109)3.76088734
22Pancreatic cysts (HP:0001737)3.72628557
23Occipital encephalocele (HP:0002085)3.62414090
24Hemiplegia (HP:0002301)3.59802218
25Abnormality of midbrain morphology (HP:0002418)3.59475730
26Molar tooth sign on MRI (HP:0002419)3.59475730
27Nephronophthisis (HP:0000090)3.44847366
28Hemiparesis (HP:0001269)3.44320407
29Abnormality of binocular vision (HP:0011514)3.43457576
30Diplopia (HP:0000651)3.43457576
31Cystic liver disease (HP:0006706)3.42362350
32Dysdiadochokinesis (HP:0002075)3.38993082
33Recurrent otitis media (HP:0000403)3.33096557
34Male infertility (HP:0003251)3.32588042
35Postural instability (HP:0002172)2.99088999
36Genetic anticipation (HP:0003743)2.96074938
37Gaze-evoked nystagmus (HP:0000640)2.93637259
38Visual hallucinations (HP:0002367)2.92334568
39Generalized tonic-clonic seizures (HP:0002069)2.91498636
40Hyperactive renin-angiotensin system (HP:0000841)2.82322397
41Chronic otitis media (HP:0000389)2.81394232
42Abnormality of the renal medulla (HP:0100957)2.80778363
43Atonic seizures (HP:0010819)2.78958283
44Broad-based gait (HP:0002136)2.77743345
45Supranuclear gaze palsy (HP:0000605)2.72718121
46Absence seizures (HP:0002121)2.70070591
47Postaxial foot polydactyly (HP:0001830)2.66646046
48Abnormal eating behavior (HP:0100738)2.63309614
49Dialeptic seizures (HP:0011146)2.61562791
50Depression (HP:0000716)2.56928927
51Clumsiness (HP:0002312)2.54851896
52Intention tremor (HP:0002080)2.52875592
53Truncal ataxia (HP:0002078)2.51771428
54Atelectasis (HP:0100750)2.46760145
55Congenital hepatic fibrosis (HP:0002612)2.43759711
56Medial flaring of the eyebrow (HP:0010747)2.43383662
57Urinary bladder sphincter dysfunction (HP:0002839)2.42798551
58Tubulointerstitial nephritis (HP:0001970)2.42243256
59Stereotypic behavior (HP:0000733)2.38152351
60Poor eye contact (HP:0000817)2.37360322
61Ankle clonus (HP:0011448)2.34840858
62Split foot (HP:0001839)2.34027916
63Status epilepticus (HP:0002133)2.33915619
64Dysmetria (HP:0001310)2.33443985
65Impaired vibration sensation in the lower limbs (HP:0002166)2.29833179
66Impaired smooth pursuit (HP:0007772)2.29683948
67Anencephaly (HP:0002323)2.29576257
68Decreased circulating renin level (HP:0003351)2.29372707
69Tubular atrophy (HP:0000092)2.28521831
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.27652974
71Scanning speech (HP:0002168)2.26424301
72Abnormal social behavior (HP:0012433)2.24200252
73Impaired social interactions (HP:0000735)2.24200252
74Abnormality of ocular smooth pursuit (HP:0000617)2.23656300
75Hyperventilation (HP:0002883)2.22297689
76Trigonocephaly (HP:0000243)2.22113884
77Severe global developmental delay (HP:0011344)2.15735035
78Male pseudohermaphroditism (HP:0000037)2.13422478
79Bradykinesia (HP:0002067)2.11930852
80Gait imbalance (HP:0002141)2.11853461
81Synostosis involving the elbow (HP:0003938)2.10822896
82Humeroradial synostosis (HP:0003041)2.10822896
83Spinal canal stenosis (HP:0003416)2.10106990
84Congenital primary aphakia (HP:0007707)2.07728947
85Neurofibrillary tangles (HP:0002185)2.07383558
86Sclerocornea (HP:0000647)2.07361921
87Chronic hepatic failure (HP:0100626)2.06682717
88Furrowed tongue (HP:0000221)2.05989347
89Aplasia/Hypoplasia of the spleen (HP:0010451)2.03936883
90Anxiety (HP:0000739)2.01925318
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6230191
92Abnormal respiratory motile cilium morphology (HP:0005938)10.5218682
93Abnormal respiratory epithelium morphology (HP:0012253)10.5218682
94Abnormal respiratory motile cilium physiology (HP:0012261)10.3396314
95Dynein arm defect of respiratory motile cilia (HP:0012255)10.3252836
96Absent/shortened dynein arms (HP:0200106)10.3252836
97Abnormal ciliary motility (HP:0012262)10.2180993
98Annular pancreas (HP:0001734)1.99423701
99Asplenia (HP:0001746)1.98493237
100Fetal akinesia sequence (HP:0001989)1.98364058
101Bell-shaped thorax (HP:0001591)1.91407318
102Pointed chin (HP:0000307)1.89156501
103Fibular aplasia (HP:0002990)1.87704747
104Dysmetric saccades (HP:0000641)1.87047778
105Renal salt wasting (HP:0000127)1.86232952
106Oculomotor apraxia (HP:0000657)1.83654520
107Lower limb muscle weakness (HP:0007340)1.83072178
108Abnormal drinking behavior (HP:0030082)1.83028392
109Polydipsia (HP:0001959)1.83028392
110Hyperkalemia (HP:0002153)1.82055299
111Increased circulating renin level (HP:0000848)1.81996177
112Hypoplastic left heart (HP:0004383)1.81740568
113Nephrogenic diabetes insipidus (HP:0009806)1.81058510
114Abnormality of the renal cortex (HP:0011035)1.80016032
115Postaxial hand polydactyly (HP:0001162)1.79927641
116Abnormality of cochlea (HP:0000375)1.78580175
117Narrow nasal bridge (HP:0000446)1.78516329
118Adactyly (HP:0009776)1.78042931
119Deeply set eye (HP:0000490)1.75310192
120Impaired vibratory sensation (HP:0002495)1.75219603
121Macroorchidism (HP:0000053)1.74948877
122Insomnia (HP:0100785)1.73833287
123Spastic gait (HP:0002064)1.73579170
124Abnormality of renin-angiotensin system (HP:0000847)1.73179990
125Recurrent bronchitis (HP:0002837)1.72544716
126Hyperaldosteronism (HP:0000859)1.72457343
127Torticollis (HP:0000473)1.71173935
128Excessive salivation (HP:0003781)1.70488611
129Drooling (HP:0002307)1.70488611
130Abnormality of the middle phalanges of the toes (HP:0010183)1.70181623
131Acute lymphatic leukemia (HP:0006721)1.69629163
132Obsessive-compulsive behavior (HP:0000722)1.69072331
133Hypoplastic nipples (HP:0002557)1.68519667
134Bronchomalacia (HP:0002780)1.68069994
135Rigidity (HP:0002063)1.67664494
136Pancreatic fibrosis (HP:0100732)1.67602458
137Prolonged QT interval (HP:0001657)1.67506642
138Elfin facies (HP:0004428)1.66666613
139Nephropathy (HP:0000112)1.65308229
140Obstructive sleep apnea (HP:0002870)1.65129396
141Abnormal EKG (HP:0003115)1.64217679
142Abnormality of the periventricular white matter (HP:0002518)1.61850587
143Abnormality of the dental pulp (HP:0006479)1.61691104
144Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61260102
145Epileptiform EEG discharges (HP:0011182)1.60246145
146Abnormality of saccadic eye movements (HP:0000570)1.59463418
147Open mouth (HP:0000194)1.57208701
148EEG with generalized epileptiform discharges (HP:0011198)1.57108484
149Polyphagia (HP:0002591)1.56895188
150Genital tract atresia (HP:0001827)1.56826603
151Decreased central vision (HP:0007663)1.56227099
152Papilledema (HP:0001085)1.56006443
153Tubulointerstitial abnormality (HP:0001969)1.55945389
154Limb ataxia (HP:0002070)1.55810704
155Cutaneous syndactyly (HP:0012725)1.54870244
156Vaginal atresia (HP:0000148)1.54515106
157Abnormality of the diencephalon (HP:0010662)1.53921131
158Preaxial hand polydactyly (HP:0001177)1.53413049
159Aqueductal stenosis (HP:0002410)1.53264524
160Bile duct proliferation (HP:0001408)1.52573093
161Abnormal biliary tract physiology (HP:0012439)1.52573093
162Oligodactyly (hands) (HP:0001180)1.50831833
163Focal dystonia (HP:0004373)1.50668742
164Abnormality of macular pigmentation (HP:0008002)1.50490979
165Enlarged penis (HP:0000040)1.50423128
1662-3 toe syndactyly (HP:0004691)1.50278122
167Abnormal rod and cone electroretinograms (HP:0008323)1.49150890
168Abnormality of chloride homeostasis (HP:0011422)1.47727753
169Absent speech (HP:0001344)1.47346007
170Poor coordination (HP:0002370)1.45111992
171Hypokalemic alkalosis (HP:0001949)1.42744191
172Stage 5 chronic kidney disease (HP:0003774)1.33634273
173Median cleft lip (HP:0000161)1.31945091
174Absent frontal sinuses (HP:0002688)1.31619208
175Retinitis pigmentosa (HP:0000510)1.29379491
176Polyuria (HP:0000103)1.25473377
177Congenital stationary night blindness (HP:0007642)1.20983303
178Short thorax (HP:0010306)1.20236998
179Tubulointerstitial fibrosis (HP:0005576)1.19518091
180Supernumerary spleens (HP:0009799)1.17780483
181Abnormality of renal excretion (HP:0011036)1.16778551
182Abolished electroretinogram (ERG) (HP:0000550)1.13675001
183Narrow forehead (HP:0000341)1.12733411
184Aganglionic megacolon (HP:0002251)1.08561160
185Prominent nasal bridge (HP:0000426)1.07821318
186Cone-rod dystrophy (HP:0000548)1.07450375
187Abnormality of permanent molar morphology (HP:0011071)1.07180341
188Abnormality of the dental root (HP:0006486)1.07180341
189Taurodontia (HP:0000679)1.07180341
190Bony spicule pigmentary retinopathy (HP:0007737)1.06690708
191Multicystic kidney dysplasia (HP:0000003)1.06565303
192Bifid scrotum (HP:0000048)1.04523063
193Renal dysplasia (HP:0000110)1.04087550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.29159883
2MST44.94008664
3TNIK4.53487905
4FRK4.33713875
5EPHA44.22772533
6NTRK33.47928348
7NTRK23.44002875
8EPHA23.23319888
9MUSK2.56971301
10PRKD32.45770325
11PHKG12.38806445
12PHKG22.38806445
13MINK12.34956009
14MAPKAPK32.32504693
15PRPF4B2.12985909
16GRK12.11396477
17MAP3K41.94025158
18MARK11.93592740
19LMTK21.91270093
20CASK1.91010350
21ADRBK21.90213997
22MAP2K71.88401403
23CAMKK11.87290019
24SGK21.85603398
25BMPR1B1.75154690
26MAPK131.67344075
27PTK2B1.65964987
28MAP2K41.63205431
29DAPK21.62116049
30TLK11.61387556
31SGK31.60383958
32NME11.60131091
33MAP3K91.57325389
34BCR1.52140608
35PAK61.50071523
36ACVR1B1.49630127
37STK241.43935705
38PNCK1.42561540
39SGK4941.38958224
40SGK2231.38958224
41OXSR11.38005348
42RIPK41.37819483
43MAP3K21.36591099
44TRIB31.36322249
45NTRK11.36119670
46CAMKK21.31623104
47WNK31.29177272
48MAP3K61.26022078
49CDK51.25521158
50WNK41.23759109
51FES1.20561330
52CAMK11.15817204
53MAP4K21.15329969
54PINK11.14670568
55MAP3K71.14462034
56SIK11.12843963
57STK381.12679093
58CDK191.08668355
59CAMK1G1.07325514
60MAP3K121.06914075
61STK38L1.03289302
62PRKCH1.03133394
63MAP3K131.01150133
64STK390.98991513
65PRKCI0.98712758
66MARK20.98257904
67INSRR0.98232745
68DAPK10.97482631
69SIK20.93480265
70CDK30.92734621
71EPHA30.92660094
72PRKCG0.92082148
73TRPM70.91907788
74RIPK10.91073530
75TTK0.86986198
76FGFR20.84206534
77RET0.83945838
78ERBB30.83744511
79EEF2K0.83155977
80FER0.83087788
81TYRO30.81572954
82KSR20.80734115
83ERBB20.79978385
84CAMK1D0.79834359
85MAP2K60.79177238
86NEK60.78390909
87STK110.75633741
88BRSK20.75602365
89TNK20.75211957
90MAPKAPK50.72035359
91TXK0.69798259
92CAMK2A0.69243520
93CSK0.67892067
94SGK10.66013980
95MATK0.64536503
96CDC42BPA0.64257896
97KSR10.64116664
98CAMK40.63007557
99PRKCQ0.62514668
100DYRK1A0.62513925
101PRKAA20.62071946
102DMPK0.59875785
103RPS6KA30.58893684
104NLK0.57668796
105CDK150.55709827
106CDK180.54085440
107TAOK30.53676232
108UHMK10.52988670
109BMX0.52213943
110PRKD20.51898633
111CSNK1G20.51665903
112FGFR30.50156004
113ADRBK10.49917924
114MAP3K30.49592191
115RPS6KB10.48971845
116CDK11A0.48282646
117PRKACA0.48236264
118IRAK10.47954195
119MAPK120.47442753
120PDK10.47396569
121MAPK70.45962411
122PAK30.44956022
123PRKG10.44921535
124FYN0.44811004
125ALK0.44236993
126PRKCE0.43186923
127TAOK20.42489767
128TAOK10.41217388
129PDPK10.40855581
130CAMK2B0.40842247
131CDK140.40429941
132PRKAA10.39794749
133MAPK100.39420148
134PRKCZ0.39100206
135MKNK20.38197182
136STK100.37989991
137FGR0.36992280
138ROCK20.36930317
139PRKCB0.36365396
140PLK20.36047648
141HIPK20.35712100
142CAMK2G0.35636954
143CAMK2D0.35564104
144PRKCA0.35274499
145KIT0.35221399
146PRKCD0.35055114
147AKT30.33392166
148EPHB10.29934238
149DYRK20.29788077
150ABL10.29381312
151MST1R0.29295524
152NUAK10.27889702
153ZAK0.26010472
154ROCK10.25413052
155TGFBR10.25044761
156SMG10.23960689
157CHUK0.21618917

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.37071126
2Nitrogen metabolism_Homo sapiens_hsa009104.32669950
3Histidine metabolism_Homo sapiens_hsa003403.92032653
4Chemical carcinogenesis_Homo sapiens_hsa052043.74516248
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.60895110
6Nicotine addiction_Homo sapiens_hsa050333.23964013
7Phenylalanine metabolism_Homo sapiens_hsa003603.18394954
8beta-Alanine metabolism_Homo sapiens_hsa004102.82562922
9Olfactory transduction_Homo sapiens_hsa047402.82037385
10Tyrosine metabolism_Homo sapiens_hsa003502.72481499
11Glutamatergic synapse_Homo sapiens_hsa047242.67114598
12Linoleic acid metabolism_Homo sapiens_hsa005912.59151356
13Circadian entrainment_Homo sapiens_hsa047132.52143823
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.50800047
15GABAergic synapse_Homo sapiens_hsa047272.49714795
16Morphine addiction_Homo sapiens_hsa050322.30014907
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23525515
18Salivary secretion_Homo sapiens_hsa049702.20627943
19Caffeine metabolism_Homo sapiens_hsa002322.15105309
20Long-term potentiation_Homo sapiens_hsa047202.11918613
21Fatty acid biosynthesis_Homo sapiens_hsa000612.10762140
22Retinol metabolism_Homo sapiens_hsa008302.08394935
23Huntingtons disease_Homo sapiens_hsa050162.07892106
24Insulin secretion_Homo sapiens_hsa049112.02750729
25Synaptic vesicle cycle_Homo sapiens_hsa047211.98735681
26Gastric acid secretion_Homo sapiens_hsa049711.96992432
27ABC transporters_Homo sapiens_hsa020101.82976280
28Amphetamine addiction_Homo sapiens_hsa050311.80531574
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80499522
30Glutathione metabolism_Homo sapiens_hsa004801.78648746
31Phototransduction_Homo sapiens_hsa047441.78253913
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66306802
33Cholinergic synapse_Homo sapiens_hsa047251.60933667
34Dopaminergic synapse_Homo sapiens_hsa047281.58630157
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57168631
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.55361420
37Calcium signaling pathway_Homo sapiens_hsa040201.53289155
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46714464
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45038308
40Cocaine addiction_Homo sapiens_hsa050301.43126570
41Taste transduction_Homo sapiens_hsa047421.39327359
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38982185
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37493391
44cAMP signaling pathway_Homo sapiens_hsa040241.36337433
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36027924
46Arachidonic acid metabolism_Homo sapiens_hsa005901.33824152
47Butanoate metabolism_Homo sapiens_hsa006501.32908921
48Long-term depression_Homo sapiens_hsa047301.31219814
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.30824141
50Sphingolipid metabolism_Homo sapiens_hsa006001.30660930
51GnRH signaling pathway_Homo sapiens_hsa049121.30163402
52Dorso-ventral axis formation_Homo sapiens_hsa043201.29235355
53Renin secretion_Homo sapiens_hsa049241.28849282
54Oxytocin signaling pathway_Homo sapiens_hsa049211.25737794
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23221364
56Circadian rhythm_Homo sapiens_hsa047101.21925303
57Serotonergic synapse_Homo sapiens_hsa047261.21456666
58Peroxisome_Homo sapiens_hsa041461.21050075
59Fatty acid degradation_Homo sapiens_hsa000711.18914629
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18194953
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14967331
62Phospholipase D signaling pathway_Homo sapiens_hsa040721.12870772
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12850052
64Glioma_Homo sapiens_hsa052141.08201506
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07852814
66Tryptophan metabolism_Homo sapiens_hsa003801.05585922
67Gap junction_Homo sapiens_hsa045401.04402043
68Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02588270
69Estrogen signaling pathway_Homo sapiens_hsa049151.01280332
70Pancreatic secretion_Homo sapiens_hsa049721.00777606
71Melanogenesis_Homo sapiens_hsa049161.00730694
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99987531
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98809021
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.97201366
75ErbB signaling pathway_Homo sapiens_hsa040120.96201789
76Tight junction_Homo sapiens_hsa045300.94581455
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93477413
78Bile secretion_Homo sapiens_hsa049760.92053757
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88327541
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86575938
81Ether lipid metabolism_Homo sapiens_hsa005650.86436425
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.85834916
83Collecting duct acid secretion_Homo sapiens_hsa049660.81052325
84Type II diabetes mellitus_Homo sapiens_hsa049300.79377201
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79111189
86Thyroid hormone synthesis_Homo sapiens_hsa049180.78372955
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77628348
88Choline metabolism in cancer_Homo sapiens_hsa052310.76299368
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69948845
90Axon guidance_Homo sapiens_hsa043600.68488980
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67915041
92Rap1 signaling pathway_Homo sapiens_hsa040150.64481189
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63993084
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.62946981
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.62922286
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62755495
97MAPK signaling pathway_Homo sapiens_hsa040100.62446020
98Dilated cardiomyopathy_Homo sapiens_hsa054140.61513463
99Inositol phosphate metabolism_Homo sapiens_hsa005620.60476242
100Endometrial cancer_Homo sapiens_hsa052130.59723165
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59469721
102Glucagon signaling pathway_Homo sapiens_hsa049220.58032114
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57764121
104Platelet activation_Homo sapiens_hsa046110.52189478
105Starch and sucrose metabolism_Homo sapiens_hsa005000.51798512
106Ras signaling pathway_Homo sapiens_hsa040140.50604048
107Glycerolipid metabolism_Homo sapiens_hsa005610.49770804
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.49137375
109Type I diabetes mellitus_Homo sapiens_hsa049400.48458442
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48249835
111Wnt signaling pathway_Homo sapiens_hsa043100.47713837
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.47698419
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47436684
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47232307
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.45897693
116Non-small cell lung cancer_Homo sapiens_hsa052230.45179051
117Propanoate metabolism_Homo sapiens_hsa006400.44677584
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44231899
119Fatty acid metabolism_Homo sapiens_hsa012120.43263137
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42221759
121Mineral absorption_Homo sapiens_hsa049780.41988638
122Ovarian steroidogenesis_Homo sapiens_hsa049130.41571395
123Chemokine signaling pathway_Homo sapiens_hsa040620.41528795
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41096716
125Metabolic pathways_Homo sapiens_hsa011000.40523220
126Regulation of autophagy_Homo sapiens_hsa041400.40399534
127Oocyte meiosis_Homo sapiens_hsa041140.39594413
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39338571
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.37680316
130Arginine and proline metabolism_Homo sapiens_hsa003300.37485294
131Hedgehog signaling pathway_Homo sapiens_hsa043400.36954430
132Insulin signaling pathway_Homo sapiens_hsa049100.36708152
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.36301957
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35164438
135Alcoholism_Homo sapiens_hsa050340.33909377
136PPAR signaling pathway_Homo sapiens_hsa033200.33830677
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33003566
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32492289
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32465233
140Cardiac muscle contraction_Homo sapiens_hsa042600.32188309
141VEGF signaling pathway_Homo sapiens_hsa043700.31964434
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31454270
143Basal cell carcinoma_Homo sapiens_hsa052170.31329653
144Colorectal cancer_Homo sapiens_hsa052100.31080372
145Vitamin digestion and absorption_Homo sapiens_hsa049770.30254539
146Prolactin signaling pathway_Homo sapiens_hsa049170.30187376
147African trypanosomiasis_Homo sapiens_hsa051430.29839271
148Asthma_Homo sapiens_hsa053100.28582492
149Selenocompound metabolism_Homo sapiens_hsa004500.24862773
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20470487
151Graft-versus-host disease_Homo sapiens_hsa053320.19140185
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18509673
153Purine metabolism_Homo sapiens_hsa002300.17544640

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