

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of action potential (GO:0045760) | 6.80043556 |
| 2 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 6.51888851 |
| 3 | cAMP biosynthetic process (GO:0006171) | 6.28247094 |
| 4 | tooth mineralization (GO:0034505) | 6.25146467 |
| 5 | positive regulation of protein sumoylation (GO:0033235) | 6.19704260 |
| 6 | neuron cell-cell adhesion (GO:0007158) | 6.15332106 |
| 7 | protein K11-linked deubiquitination (GO:0035871) | 6.05523552 |
| 8 | vocalization behavior (GO:0071625) | 6.03447799 |
| 9 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.86570516 |
| 10 | glutamate secretion (GO:0014047) | 5.79869675 |
| 11 | synaptic vesicle exocytosis (GO:0016079) | 5.71363401 |
| 12 | keratinization (GO:0031424) | 5.68513542 |
| 13 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.54475078 |
| 14 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.51079873 |
| 15 | protein localization to synapse (GO:0035418) | 5.34958092 |
| 16 | synaptic vesicle maturation (GO:0016188) | 5.34761222 |
| 17 | neuronal ion channel clustering (GO:0045161) | 5.33715575 |
| 18 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.26073149 |
| 19 | tachykinin receptor signaling pathway (GO:0007217) | 5.23203545 |
| 20 | locomotory exploration behavior (GO:0035641) | 5.15366211 |
| 21 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.12833448 |
| 22 | negative regulation of type 2 immune response (GO:0002829) | 5.10349865 |
| 23 | regulation of corticosteroid hormone secretion (GO:2000846) | 5.03924176 |
| 24 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.94591203 |
| 25 | positive regulation of RNA splicing (GO:0033120) | 4.92945693 |
| 26 | layer formation in cerebral cortex (GO:0021819) | 4.76907701 |
| 27 | righting reflex (GO:0060013) | 4.70289577 |
| 28 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.68847391 |
| 29 | negative regulation of heart rate (GO:0010459) | 4.68386274 |
| 30 | positive regulation of steroid hormone secretion (GO:2000833) | 4.66768471 |
| 31 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 4.62067877 |
| 32 | negative regulation of T-helper cell differentiation (GO:0045623) | 4.62067877 |
| 33 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.61740150 |
| 34 | seminiferous tubule development (GO:0072520) | 4.61659057 |
| 35 | exploration behavior (GO:0035640) | 4.56376638 |
| 36 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.52960579 |
| 37 | regulation of action potential (GO:0098900) | 4.52079217 |
| 38 | regulation of T-helper 2 cell differentiation (GO:0045628) | 4.51567828 |
| 39 | glutamate receptor signaling pathway (GO:0007215) | 4.50291312 |
| 40 | regulation of synaptic vesicle transport (GO:1902803) | 4.46552529 |
| 41 | regulation of glucocorticoid secretion (GO:2000849) | 4.45046510 |
| 42 | postsynaptic membrane organization (GO:0001941) | 4.40479902 |
| 43 | chemosensory behavior (GO:0007635) | 4.39027577 |
| 44 | neurotransmitter secretion (GO:0007269) | 4.36324071 |
| 45 | neuron recognition (GO:0008038) | 4.32806376 |
| 46 | presynaptic membrane assembly (GO:0097105) | 4.23402942 |
| 47 | positive regulation of T-helper 1 type immune response (GO:0002827) | 4.23352124 |
| 48 | synaptic transmission, dopaminergic (GO:0001963) | 4.17859719 |
| 49 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.12363899 |
| 50 | enteric nervous system development (GO:0048484) | 4.10563520 |
| 51 | detection of chemical stimulus involved in sensory perception (GO:0050907) | 4.09675418 |
| 52 | regulation of T-helper 1 cell differentiation (GO:0045625) | 4.08933433 |
| 53 | neuronal action potential propagation (GO:0019227) | 4.07841612 |
| 54 | dendritic spine morphogenesis (GO:0060997) | 4.07379547 |
| 55 | synaptic transmission, glutamatergic (GO:0035249) | 4.04641827 |
| 56 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.04309500 |
| 57 | positive regulation of mitochondrial fission (GO:0090141) | 4.00228916 |
| 58 | neuron-neuron synaptic transmission (GO:0007270) | 3.98190835 |
| 59 | proline transport (GO:0015824) | 3.97010038 |
| 60 | axonal fasciculation (GO:0007413) | 3.91359967 |
| 61 | positive regulation of synapse maturation (GO:0090129) | 3.91153672 |
| 62 | positive regulation of digestive system process (GO:0060456) | 3.90305444 |
| 63 | presynaptic membrane organization (GO:0097090) | 3.88637614 |
| 64 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.88324922 |
| 65 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.87174034 |
| 66 | dendritic spine organization (GO:0097061) | 3.83346234 |
| 67 | response to dietary excess (GO:0002021) | 3.81283150 |
| 68 | cellular response to glucagon stimulus (GO:0071377) | 3.77573756 |
| 69 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.75276484 |
| 70 | neurofilament cytoskeleton organization (GO:0060052) | 3.70728147 |
| 71 | gamma-aminobutyric acid transport (GO:0015812) | 3.68779191 |
| 72 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.66023576 |
| 73 | regulation of synapse structural plasticity (GO:0051823) | 3.63376709 |
| 74 | cAMP metabolic process (GO:0046058) | 3.63156169 |
| 75 | neurotransmitter transport (GO:0006836) | 3.62922976 |
| 76 | regulation of protein sumoylation (GO:0033233) | 3.61348815 |
| 77 | regulation of postsynaptic membrane potential (GO:0060078) | 3.61065964 |
| 78 | regulation of vesicle fusion (GO:0031338) | 3.56377538 |
| 79 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.54160351 |
| 80 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.52987591 |
| 81 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.52651038 |
| 82 | retina layer formation (GO:0010842) | 3.52440701 |
| 83 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.50756177 |
| 84 | synapse assembly (GO:0007416) | 3.49770060 |
| 85 | positive regulation of membrane potential (GO:0045838) | 3.49668177 |
| 86 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.48213002 |
| 87 | regulation of neurotransmitter secretion (GO:0046928) | 3.46938820 |
| 88 | long-term memory (GO:0007616) | 3.46679897 |
| 89 | cyclic purine nucleotide metabolic process (GO:0052652) | 3.46487650 |
| 90 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.46189666 |
| 91 | response to histamine (GO:0034776) | 3.42137086 |
| 92 | regulation of steroid hormone secretion (GO:2000831) | 3.42003781 |
| 93 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.41922813 |
| 94 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.38075068 |
| 95 | L-amino acid import (GO:0043092) | 3.37934755 |
| 96 | activation of protein kinase A activity (GO:0034199) | 3.37796832 |
| 97 | regulation of neurotransmitter levels (GO:0001505) | 3.36994155 |
| 98 | heterotypic cell-cell adhesion (GO:0034113) | 3.36765128 |
| 99 | cell migration in hindbrain (GO:0021535) | 3.35514232 |
| 100 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.34579162 |
| 101 | synaptic vesicle endocytosis (GO:0048488) | 3.34239503 |
| 102 | regulation of synaptic plasticity (GO:0048167) | 3.33056261 |
| 103 | cellular potassium ion homeostasis (GO:0030007) | 3.32952705 |
| 104 | cyclic nucleotide biosynthetic process (GO:0009190) | 3.32378990 |
| 105 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.31291485 |
| 106 | long-term synaptic potentiation (GO:0060291) | 3.28409566 |
| 107 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.27583977 |
| 108 | regulation of dendritic spine development (GO:0060998) | 3.27514820 |
| 109 | dendrite morphogenesis (GO:0048813) | 3.27298808 |
| 110 | auditory behavior (GO:0031223) | 3.22868646 |
| 111 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.22751920 |
| 112 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 3.22713631 |
| 113 | social behavior (GO:0035176) | 3.21827296 |
| 114 | intraspecies interaction between organisms (GO:0051703) | 3.21827296 |
| 115 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.21671966 |
| 116 | positive regulation of synapse assembly (GO:0051965) | 3.21618307 |
| 117 | cerebellar granule cell differentiation (GO:0021707) | 3.19574753 |
| 118 | innervation (GO:0060384) | 3.18633544 |
| 119 | acidic amino acid transport (GO:0015800) | 3.18591492 |
| 120 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.16694275 |
| 121 | neuromuscular process controlling posture (GO:0050884) | 3.15601557 |
| 122 | transmission of nerve impulse (GO:0019226) | 3.14399528 |
| 123 | mating behavior (GO:0007617) | 3.14267941 |
| 124 | regulation of neurotransmitter transport (GO:0051588) | 3.13824227 |
| 125 | positive regulation of neurotransmitter transport (GO:0051590) | 3.13136740 |
| 126 | detection of chemical stimulus (GO:0009593) | 3.12645001 |
| 127 | regulation of synapse maturation (GO:0090128) | 3.10937320 |
| 128 | nucleobase catabolic process (GO:0046113) | 3.10560200 |
| 129 | membrane depolarization (GO:0051899) | 3.09425698 |
| 130 | positive regulation of dendritic spine development (GO:0060999) | 3.08790708 |
| 131 | C4-dicarboxylate transport (GO:0015740) | 3.08438646 |
| 132 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.07937117 |
| 133 | response to auditory stimulus (GO:0010996) | 3.05852695 |
| 134 | positive regulation of vesicle fusion (GO:0031340) | 3.05408384 |
| 135 | synapse organization (GO:0050808) | 3.04495374 |
| 136 | organelle transport along microtubule (GO:0072384) | 3.02621796 |
| 137 | behavioral response to cocaine (GO:0048148) | 3.02060220 |
| 138 | learning (GO:0007612) | 3.00959676 |
| 139 | endothelial cell differentiation (GO:0045446) | 3.00306462 |
| 140 | L-glutamate transport (GO:0015813) | 3.00254278 |
| 141 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.99211014 |
| 142 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.98110758 |
| 143 | membrane hyperpolarization (GO:0060081) | 2.97243960 |
| 144 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.95886803 |
| 145 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.95886803 |
| 146 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.95006025 |
| 147 | synaptic vesicle transport (GO:0048489) | 2.94360624 |
| 148 | establishment of synaptic vesicle localization (GO:0097480) | 2.94360624 |
| 149 | synaptic transmission (GO:0007268) | 2.94023433 |
| 150 | membrane depolarization during action potential (GO:0086010) | 2.93850339 |
| 151 | negative regulation of microtubule polymerization (GO:0031115) | 2.93801084 |
| 152 | water transport (GO:0006833) | 2.92908408 |
| 153 | phosphatidylglycerol acyl-chain remodeling (GO:0036148) | 2.92779666 |
| 154 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.92704000 |
| 155 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.92109843 |
| 156 | response to glucagon (GO:0033762) | 2.90524904 |
| 157 | neuromuscular process controlling balance (GO:0050885) | 2.90076429 |
| 158 | regulation of synapse assembly (GO:0051963) | 2.89624592 |
| 159 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 2.87242399 |
| 160 | vesicle transport along microtubule (GO:0047496) | 2.85930788 |
| 161 | establishment of mitochondrion localization (GO:0051654) | 2.85902493 |
| 162 | negative regulation of neurotransmitter transport (GO:0051589) | 2.85832256 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.10797824 |
| 2 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 4.41300155 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.90902798 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.15947434 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.10427703 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.98336985 |
| 7 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.87569602 |
| 8 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.69791751 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.64600583 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.64600583 |
| 11 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.60946417 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.58900078 |
| 13 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.53222660 |
| 14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.52521193 |
| 15 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.52042826 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.47423472 |
| 17 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.45966258 |
| 18 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.44368710 |
| 19 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.28173366 |
| 20 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.26468294 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.24250379 |
| 22 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.23966773 |
| 23 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.23173267 |
| 24 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.20767315 |
| 25 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.14027614 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.10661149 |
| 27 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.10470124 |
| 28 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.10099615 |
| 29 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.09041439 |
| 30 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.08869319 |
| 31 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.99918653 |
| 32 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.90240348 |
| 33 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.84980186 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.74181604 |
| 35 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.73451458 |
| 36 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.71175162 |
| 37 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.70687661 |
| 38 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.67404258 |
| 39 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.60603592 |
| 40 | P300_19829295_ChIP-Seq_ESCs_Human | 1.59703383 |
| 41 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.58477435 |
| 42 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.48011366 |
| 43 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.46109780 |
| 44 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.44420566 |
| 45 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.44044565 |
| 46 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.43204899 |
| 47 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.42586174 |
| 48 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.41188659 |
| 49 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.37649573 |
| 50 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.37617785 |
| 51 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.36752600 |
| 52 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.36179947 |
| 53 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.35828816 |
| 54 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.35021676 |
| 55 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.34389870 |
| 56 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.33869588 |
| 57 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.33556613 |
| 58 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.32914875 |
| 59 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.32148478 |
| 60 | FUS_26573619_Chip-Seq_HEK293_Human | 1.30787567 |
| 61 | AR_25329375_ChIP-Seq_VCAP_Human | 1.30527553 |
| 62 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.30499239 |
| 63 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.29422033 |
| 64 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.28252225 |
| 65 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.27055579 |
| 66 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.26394380 |
| 67 | RXR_22108803_ChIP-Seq_LS180_Human | 1.25767958 |
| 68 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.25640200 |
| 69 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.25419060 |
| 70 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.24143102 |
| 71 | STAT3_23295773_ChIP-Seq_U87_Human | 1.23692561 |
| 72 | VDR_22108803_ChIP-Seq_LS180_Human | 1.20727061 |
| 73 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.19791459 |
| 74 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.17709622 |
| 75 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.16375272 |
| 76 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.14677757 |
| 77 | AR_19668381_ChIP-Seq_PC3_Human | 1.13891246 |
| 78 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.13358825 |
| 79 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.10744277 |
| 80 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.10721065 |
| 81 | TCF4_23295773_ChIP-Seq_U87_Human | 1.10141070 |
| 82 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.09674935 |
| 83 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.09002338 |
| 84 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.08483935 |
| 85 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.07852465 |
| 86 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.05295102 |
| 87 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.05076059 |
| 88 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.04850846 |
| 89 | TP53_16413492_ChIP-PET_HCT116_Human | 1.04243602 |
| 90 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.03893525 |
| 91 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.03688794 |
| 92 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.03273484 |
| 93 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.02704908 |
| 94 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.02704908 |
| 95 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.02666708 |
| 96 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.02530933 |
| 97 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.02420335 |
| 98 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.01192534 |
| 99 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.00958557 |
| 100 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.00818522 |
| 101 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.00130159 |
| 102 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99683923 |
| 103 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.99377134 |
| 104 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.99110869 |
| 105 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.98564475 |
| 106 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.98194226 |
| 107 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.96877138 |
| 108 | JUN_21703547_ChIP-Seq_K562_Human | 0.96574239 |
| 109 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.95257956 |
| 110 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94575453 |
| 111 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.94376549 |
| 112 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.93887633 |
| 113 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.93134790 |
| 114 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92417003 |
| 115 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91882620 |
| 116 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.90905744 |
| 117 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.90566909 |
| 118 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.90197184 |
| 119 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.90187041 |
| 120 | KDM2B_26808549_Chip-Seq_REH_Human | 0.89506588 |
| 121 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.86864169 |
| 122 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.83435466 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.94370068 |
| 2 | MP0003880_abnormal_central_pattern | 5.55571924 |
| 3 | MP0005084_abnormal_gallbladder_morpholo | 5.17102653 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 4.05040370 |
| 5 | MP0008961_abnormal_basal_metabolism | 3.98634937 |
| 6 | MP0004270_analgesia | 3.97506020 |
| 7 | MP0001968_abnormal_touch/_nociception | 3.47547014 |
| 8 | MP0009745_abnormal_behavioral_response | 3.27066219 |
| 9 | MP0002063_abnormal_learning/memory/cond | 3.23198448 |
| 10 | MP0009046_muscle_twitch | 3.14129056 |
| 11 | MP0002064_seizures | 3.00661107 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.92422860 |
| 13 | MP0005423_abnormal_somatic_nervous | 2.92050755 |
| 14 | MP0002736_abnormal_nociception_after | 2.78268206 |
| 15 | MP0002572_abnormal_emotion/affect_behav | 2.76487751 |
| 16 | MP0002735_abnormal_chemical_nociception | 2.71402011 |
| 17 | MP0001486_abnormal_startle_reflex | 2.56792285 |
| 18 | MP0004130_abnormal_muscle_cell | 2.51595263 |
| 19 | MP0002272_abnormal_nervous_system | 2.43844222 |
| 20 | MP0002733_abnormal_thermal_nociception | 2.41179383 |
| 21 | MP0001440_abnormal_grooming_behavior | 2.35966713 |
| 22 | MP0009780_abnormal_chondrocyte_physiolo | 2.34544374 |
| 23 | MP0006276_abnormal_autonomic_nervous | 2.34163309 |
| 24 | MP0001501_abnormal_sleep_pattern | 2.24564115 |
| 25 | MP0000778_abnormal_nervous_system | 2.15373615 |
| 26 | MP0001970_abnormal_pain_threshold | 2.11772993 |
| 27 | MP0002067_abnormal_sensory_capabilities | 2.08629152 |
| 28 | MP0002184_abnormal_innervation | 2.02973461 |
| 29 | MP0003329_amyloid_beta_deposits | 1.98485403 |
| 30 | MP0004924_abnormal_behavior | 1.85808795 |
| 31 | MP0005386_behavior/neurological_phenoty | 1.85808795 |
| 32 | MP0002557_abnormal_social/conspecific_i | 1.77746036 |
| 33 | MP0004858_abnormal_nervous_system | 1.76665335 |
| 34 | MP0004811_abnormal_neuron_physiology | 1.71937279 |
| 35 | MP0003879_abnormal_hair_cell | 1.69751177 |
| 36 | MP0002796_impaired_skin_barrier | 1.61055251 |
| 37 | MP0001905_abnormal_dopamine_level | 1.59449323 |
| 38 | MP0000955_abnormal_spinal_cord | 1.58249649 |
| 39 | MP0001188_hyperpigmentation | 1.52056293 |
| 40 | MP0008569_lethality_at_weaning | 1.49655719 |
| 41 | MP0001984_abnormal_olfaction | 1.47134003 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.43912706 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.41686872 |
| 44 | MP0002751_abnormal_autonomic_nervous | 1.41543078 |
| 45 | MP0002909_abnormal_adrenal_gland | 1.41313904 |
| 46 | MP0004133_heterotaxia | 1.37927389 |
| 47 | MP0000579_abnormal_nail_morphology | 1.37522815 |
| 48 | MP0005448_abnormal_energy_balance | 1.34097124 |
| 49 | MP0001529_abnormal_vocalization | 1.33050623 |
| 50 | MP0002822_catalepsy | 1.32491829 |
| 51 | MP0001502_abnormal_circadian_rhythm | 1.23336286 |
| 52 | MP0010234_abnormal_vibrissa_follicle | 1.22128826 |
| 53 | MP0005646_abnormal_pituitary_gland | 1.22105311 |
| 54 | MP0005645_abnormal_hypothalamus_physiol | 1.21407357 |
| 55 | MP0003121_genomic_imprinting | 1.17546732 |
| 56 | MP0004142_abnormal_muscle_tone | 1.17296658 |
| 57 | MP0002837_dystrophic_cardiac_calcinosis | 1.17228198 |
| 58 | MP0003252_abnormal_bile_duct | 1.16406647 |
| 59 | MP0003633_abnormal_nervous_system | 1.14707879 |
| 60 | MP0004742_abnormal_vestibular_system | 1.13934601 |
| 61 | MP0002928_abnormal_bile_duct | 1.11342013 |
| 62 | MP0002152_abnormal_brain_morphology | 1.11124055 |
| 63 | MP0004885_abnormal_endolymph | 1.08100473 |
| 64 | MP0003122_maternal_imprinting | 1.03921352 |
| 65 | MP0000751_myopathy | 1.03678592 |
| 66 | MP0000569_abnormal_digit_pigmentation | 1.03557653 |
| 67 | MP0003123_paternal_imprinting | 1.02139336 |
| 68 | MP0003631_nervous_system_phenotype | 1.01441415 |
| 69 | MP0005551_abnormal_eye_electrophysiolog | 1.00873608 |
| 70 | MP0004233_abnormal_muscle_weight | 0.97509057 |
| 71 | MP0008872_abnormal_physiological_respon | 0.97236399 |
| 72 | MP0004145_abnormal_muscle_electrophysio | 0.97018940 |
| 73 | MP0005409_darkened_coat_color | 0.95989897 |
| 74 | MP0003787_abnormal_imprinting | 0.94393190 |
| 75 | MP0010386_abnormal_urinary_bladder | 0.93446554 |
| 76 | MP0005535_abnormal_body_temperature | 0.93328317 |
| 77 | MP0000604_amyloidosis | 0.92418287 |
| 78 | MP0002229_neurodegeneration | 0.91980137 |
| 79 | MP0000631_abnormal_neuroendocrine_gland | 0.89494722 |
| 80 | MP0002069_abnormal_eating/drinking_beha | 0.87424157 |
| 81 | MP0002752_abnormal_somatic_nervous | 0.86764921 |
| 82 | MP0001963_abnormal_hearing_physiology | 0.85650941 |
| 83 | MP0004264_abnormal_extraembryonic_tissu | 0.84308077 |
| 84 | MP0008874_decreased_physiological_sensi | 0.81946322 |
| 85 | MP0004085_abnormal_heartbeat | 0.79715118 |
| 86 | MP0001664_abnormal_digestion | 0.78242725 |
| 87 | MP0002876_abnormal_thyroid_physiology | 0.76133711 |
| 88 | MP0003941_abnormal_skin_development | 0.75346814 |
| 89 | MP0003634_abnormal_glial_cell | 0.75146915 |
| 90 | MP0003632_abnormal_nervous_system | 0.71315170 |
| 91 | MP0006072_abnormal_retinal_apoptosis | 0.70842642 |
| 92 | MP0004484_altered_response_of | 0.69119500 |
| 93 | MP0004215_abnormal_myocardial_fiber | 0.67842465 |
| 94 | MP0005187_abnormal_penis_morphology | 0.66427684 |
| 95 | MP0002098_abnormal_vibrissa_morphology | 0.66057300 |
| 96 | MP0009379_abnormal_foot_pigmentation | 0.65409853 |
| 97 | MP0005248_abnormal_Harderian_gland | 0.63282068 |
| 98 | MP0003861_abnormal_nervous_system | 0.62997175 |
| 99 | MP0001348_abnormal_lacrimal_gland | 0.62045600 |
| 100 | MP0002090_abnormal_vision | 0.61541067 |
| 101 | MP0005394_taste/olfaction_phenotype | 0.60800323 |
| 102 | MP0005499_abnormal_olfactory_system | 0.60800323 |
| 103 | MP0001177_atelectasis | 0.60312160 |
| 104 | MP0001756_abnormal_urination | 0.59256834 |
| 105 | MP0002102_abnormal_ear_morphology | 0.58897896 |
| 106 | MP0000920_abnormal_myelination | 0.58878086 |
| 107 | MP0000026_abnormal_inner_ear | 0.58833805 |
| 108 | MP0002638_abnormal_pupillary_reflex | 0.58813034 |
| 109 | MP0004510_myositis | 0.58735371 |
| 110 | MP0001986_abnormal_taste_sensitivity | 0.58523759 |
| 111 | MP0001270_distended_abdomen | 0.56710915 |
| 112 | MP0000013_abnormal_adipose_tissue | 0.55832219 |
| 113 | MP0001943_abnormal_respiration | 0.55404030 |
| 114 | MP0005275_abnormal_skin_tensile | 0.54625033 |
| 115 | MP0001485_abnormal_pinna_reflex | 0.54615611 |
| 116 | MP0005623_abnormal_meninges_morphology | 0.53196371 |
| 117 | MP0005253_abnormal_eye_physiology | 0.53140242 |
| 118 | MP0003938_abnormal_ear_development | 0.52766931 |
| 119 | MP0010770_preweaning_lethality | 0.51821350 |
| 120 | MP0002082_postnatal_lethality | 0.51821350 |
| 121 | MP0010769_abnormal_survival | 0.51282203 |
| 122 | MP0003137_abnormal_impulse_conducting | 0.51106618 |
| 123 | MP0002234_abnormal_pharynx_morphology | 0.49952726 |
| 124 | MP0001299_abnormal_eye_distance/ | 0.48152367 |
| 125 | MP0003283_abnormal_digestive_organ | 0.47644974 |
| 126 | MP0005220_abnormal_exocrine_pancreas | 0.47340682 |
| 127 | MP0010768_mortality/aging | 0.46508127 |
| 128 | MP0003011_delayed_dark_adaptation | 0.44015787 |
| 129 | MP0003956_abnormal_body_size | 0.43670185 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.11929967 |
| 2 | Overgrowth (HP:0001548) | 6.36299216 |
| 3 | Focal seizures (HP:0007359) | 5.77289386 |
| 4 | Myokymia (HP:0002411) | 5.58274237 |
| 5 | Visual hallucinations (HP:0002367) | 5.39059336 |
| 6 | Epileptic encephalopathy (HP:0200134) | 5.38552826 |
| 7 | Amelogenesis imperfecta (HP:0000705) | 5.14707373 |
| 8 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 5.13784242 |
| 9 | Atonic seizures (HP:0010819) | 4.65935140 |
| 10 | Limb dystonia (HP:0002451) | 4.51603592 |
| 11 | Absence seizures (HP:0002121) | 4.33140615 |
| 12 | Abnormality of nail color (HP:0100643) | 4.25237881 |
| 13 | Osteomalacia (HP:0002749) | 4.15717348 |
| 14 | Hyperventilation (HP:0002883) | 4.15168446 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 4.11600302 |
| 16 | Broad-based gait (HP:0002136) | 4.08976316 |
| 17 | Febrile seizures (HP:0002373) | 4.05086020 |
| 18 | Parakeratosis (HP:0001036) | 3.99682329 |
| 19 | Abnormality of dental color (HP:0011073) | 3.94105242 |
| 20 | Dialeptic seizures (HP:0011146) | 3.90111043 |
| 21 | Generalized tonic-clonic seizures (HP:0002069) | 3.83719788 |
| 22 | Mutism (HP:0002300) | 3.73420280 |
| 23 | Poor eye contact (HP:0000817) | 3.68739009 |
| 24 | Supranuclear gaze palsy (HP:0000605) | 3.65184239 |
| 25 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.54125616 |
| 26 | Abnormality of renal resorption (HP:0011038) | 3.51049962 |
| 27 | Abnormality of the dental pulp (HP:0006479) | 3.50044639 |
| 28 | Cerebral inclusion bodies (HP:0100314) | 3.43699619 |
| 29 | Insidious onset (HP:0003587) | 3.35641499 |
| 30 | Termporal pattern (HP:0011008) | 3.35641499 |
| 31 | Polyuria (HP:0000103) | 3.34554169 |
| 32 | Amblyopia (HP:0000646) | 3.33142458 |
| 33 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.25063641 |
| 34 | Neurofibrillary tangles (HP:0002185) | 3.22973838 |
| 35 | Excessive salivation (HP:0003781) | 3.22615449 |
| 36 | Drooling (HP:0002307) | 3.22615449 |
| 37 | Abnormal social behavior (HP:0012433) | 3.21570217 |
| 38 | Impaired social interactions (HP:0000735) | 3.21570217 |
| 39 | Abnormality of the corticospinal tract (HP:0002492) | 3.21106061 |
| 40 | Action tremor (HP:0002345) | 3.18463224 |
| 41 | Ankle clonus (HP:0011448) | 3.17097364 |
| 42 | Gaze-evoked nystagmus (HP:0000640) | 3.08128932 |
| 43 | Inability to walk (HP:0002540) | 3.08128681 |
| 44 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.05578989 |
| 45 | Amyotrophic lateral sclerosis (HP:0007354) | 3.00618696 |
| 46 | Truncal ataxia (HP:0002078) | 2.98439651 |
| 47 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.94072716 |
| 48 | Volvulus (HP:0002580) | 2.89990119 |
| 49 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.89617181 |
| 50 | Abnormal eating behavior (HP:0100738) | 2.88873035 |
| 51 | Papilledema (HP:0001085) | 2.84945732 |
| 52 | Progressive inability to walk (HP:0002505) | 2.81848822 |
| 53 | Abnormal urine output (HP:0012590) | 2.80817187 |
| 54 | Pheochromocytoma (HP:0002666) | 2.80511283 |
| 55 | Depression (HP:0000716) | 2.78236364 |
| 56 | Akinesia (HP:0002304) | 2.78060626 |
| 57 | Dysdiadochokinesis (HP:0002075) | 2.77276868 |
| 58 | Epileptiform EEG discharges (HP:0011182) | 2.76609481 |
| 59 | Polyphagia (HP:0002591) | 2.74828733 |
| 60 | Diplopia (HP:0000651) | 2.72607562 |
| 61 | Abnormality of binocular vision (HP:0011514) | 2.72607562 |
| 62 | Urinary urgency (HP:0000012) | 2.70846358 |
| 63 | Anxiety (HP:0000739) | 2.67518182 |
| 64 | Dysmetria (HP:0001310) | 2.67336791 |
| 65 | EEG with generalized epileptiform discharges (HP:0011198) | 2.67235411 |
| 66 | Genetic anticipation (HP:0003743) | 2.62228415 |
| 67 | Stereotypic behavior (HP:0000733) | 2.53362140 |
| 68 | Spastic gait (HP:0002064) | 2.52737254 |
| 69 | Absent speech (HP:0001344) | 2.48813556 |
| 70 | Bradykinesia (HP:0002067) | 2.48253831 |
| 71 | Fetal akinesia sequence (HP:0001989) | 2.47470561 |
| 72 | Hypsarrhythmia (HP:0002521) | 2.47261299 |
| 73 | Difficulty running (HP:0009046) | 2.45877393 |
| 74 | Inappropriate behavior (HP:0000719) | 2.45804233 |
| 75 | Neuroendocrine neoplasm (HP:0100634) | 2.43451232 |
| 76 | Postural instability (HP:0002172) | 2.42003290 |
| 77 | Torticollis (HP:0000473) | 2.41590709 |
| 78 | Hemiparesis (HP:0001269) | 2.41193951 |
| 79 | Erythema (HP:0010783) | 2.39132089 |
| 80 | Increased IgE level (HP:0003212) | 2.38816339 |
| 81 | Erythroderma (HP:0001019) | 2.38317640 |
| 82 | Palmoplantar hyperkeratosis (HP:0000972) | 2.38118264 |
| 83 | Palmar hyperkeratosis (HP:0010765) | 2.38013451 |
| 84 | Large earlobe (HP:0009748) | 2.34130652 |
| 85 | Abnormality of renal excretion (HP:0011036) | 2.32731591 |
| 86 | Ectropion (HP:0000656) | 2.32499032 |
| 87 | Agitation (HP:0000713) | 2.31968665 |
| 88 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.31523698 |
| 89 | Decreased muscle mass (HP:0003199) | 2.29924225 |
| 90 | Impaired smooth pursuit (HP:0007772) | 2.28425726 |
| 91 | Generalized myoclonic seizures (HP:0002123) | 2.26954259 |
| 92 | Protruding tongue (HP:0010808) | 2.26764165 |
| 93 | Abnormality of salivation (HP:0100755) | 2.22874497 |
| 94 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.22448163 |
| 95 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.22448163 |
| 96 | Focal dystonia (HP:0004373) | 2.20211914 |
| 97 | Lower limb muscle weakness (HP:0007340) | 2.19234622 |
| 98 | Scanning speech (HP:0002168) | 2.17010102 |
| 99 | Gait imbalance (HP:0002141) | 2.15982572 |
| 100 | Hyperthyroidism (HP:0000836) | 2.15479149 |
| 101 | Abnormality of the lower motor neuron (HP:0002366) | 2.14392498 |
| 102 | Status epilepticus (HP:0002133) | 2.13954776 |
| 103 | Lower limb amyotrophy (HP:0007210) | 2.10581999 |
| 104 | Lip pit (HP:0100267) | 2.08428939 |
| 105 | Chronic bronchitis (HP:0004469) | 2.07453116 |
| 106 | Craniofacial dystonia (HP:0012179) | 2.06368980 |
| 107 | Hypoventilation (HP:0002791) | 2.04826943 |
| 108 | Round ear (HP:0100830) | 2.03075501 |
| 109 | Hypoplasia of the brainstem (HP:0002365) | 2.02637307 |
| 110 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.02637307 |
| 111 | Blue irides (HP:0000635) | 2.02019881 |
| 112 | Delusions (HP:0000746) | 2.00163673 |
| 113 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.97879229 |
| 114 | Follicular hyperkeratosis (HP:0007502) | 1.97446484 |
| 115 | Open mouth (HP:0000194) | 1.97102955 |
| 116 | Hip dysplasia (HP:0001385) | 1.92642726 |
| 117 | Apathy (HP:0000741) | 1.90912006 |
| 118 | Impaired vibratory sensation (HP:0002495) | 1.90852208 |
| 119 | Poor suck (HP:0002033) | 1.90131634 |
| 120 | Psychosis (HP:0000709) | 1.86430301 |
| 121 | Plantar hyperkeratosis (HP:0007556) | 1.86400420 |
| 122 | Gastroesophageal reflux (HP:0002020) | 1.85985669 |
| 123 | Epidermoid cyst (HP:0200040) | 1.85440652 |
| 124 | Personality changes (HP:0000751) | 1.84830253 |
| 125 | Exotropia (HP:0000577) | 1.84669514 |
| 126 | Intention tremor (HP:0002080) | 1.84100489 |
| 127 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.83035797 |
| 128 | Megalencephaly (HP:0001355) | 1.82188069 |
| 129 | Rapidly progressive (HP:0003678) | 1.81155197 |
| 130 | Incomplete penetrance (HP:0003829) | 1.81039256 |
| 131 | Palmoplantar keratoderma (HP:0000982) | 1.80171425 |
| 132 | Gait ataxia (HP:0002066) | 1.79266075 |
| 133 | Thick eyebrow (HP:0000574) | 1.78870185 |
| 134 | Hemiplegia (HP:0002301) | 1.78752123 |
| 135 | Thoracolumbar scoliosis (HP:0002944) | 1.78727569 |
| 136 | Nephrocalcinosis (HP:0000121) | 1.78453440 |
| 137 | Rigidity (HP:0002063) | 1.77581291 |
| 138 | Obstructive sleep apnea (HP:0002870) | 1.76262230 |
| 139 | Failure to thrive in infancy (HP:0001531) | 1.75726559 |
| 140 | Abnormality of midbrain morphology (HP:0002418) | 1.74617565 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 4.71367315 |
| 2 | MAP3K9 | 3.91595449 |
| 3 | NTRK3 | 3.80245424 |
| 4 | EPHA4 | 3.65661062 |
| 5 | CASK | 3.15988196 |
| 6 | MAP3K4 | 2.94632028 |
| 7 | MAP2K7 | 2.70897938 |
| 8 | MINK1 | 2.70056789 |
| 9 | DAPK2 | 2.57658853 |
| 10 | MAP3K12 | 2.45044770 |
| 11 | SIK2 | 2.13672593 |
| 12 | EPHA2 | 2.11803197 |
| 13 | RIPK4 | 2.08379709 |
| 14 | PAK6 | 2.08265468 |
| 15 | PNCK | 2.00361456 |
| 16 | NTRK2 | 1.98949507 |
| 17 | MAP2K4 | 1.96038027 |
| 18 | NTRK1 | 1.84959207 |
| 19 | PLK2 | 1.82607042 |
| 20 | KSR2 | 1.80858232 |
| 21 | STK3 | 1.74020673 |
| 22 | MAPK13 | 1.73679835 |
| 23 | GRK5 | 1.62853135 |
| 24 | LATS2 | 1.54842382 |
| 25 | KSR1 | 1.53153163 |
| 26 | DAPK1 | 1.52042775 |
| 27 | CCNB1 | 1.46928596 |
| 28 | PHKG2 | 1.46444200 |
| 29 | PHKG1 | 1.46444200 |
| 30 | CDK5 | 1.46228277 |
| 31 | MAP4K1 | 1.38815799 |
| 32 | TNIK | 1.37298982 |
| 33 | BLK | 1.32458457 |
| 34 | CAMKK1 | 1.32074748 |
| 35 | PINK1 | 1.30105024 |
| 36 | CSNK1G2 | 1.25706103 |
| 37 | CDK19 | 1.17909081 |
| 38 | PRKCG | 1.17733743 |
| 39 | PRPF4B | 1.08143334 |
| 40 | CAMK2A | 1.07941150 |
| 41 | CAMKK2 | 1.04706687 |
| 42 | ARAF | 1.00187715 |
| 43 | MAP3K2 | 0.95670841 |
| 44 | RET | 0.94889146 |
| 45 | UHMK1 | 0.89032170 |
| 46 | CDK14 | 0.88144352 |
| 47 | CDK18 | 0.86560088 |
| 48 | CDK15 | 0.84812032 |
| 49 | MAP3K13 | 0.84556394 |
| 50 | DYRK3 | 0.84009951 |
| 51 | DYRK2 | 0.83735163 |
| 52 | PAK3 | 0.80767096 |
| 53 | FES | 0.80639388 |
| 54 | PRKD3 | 0.79509614 |
| 55 | CAMK4 | 0.79368502 |
| 56 | CSNK1G3 | 0.77519070 |
| 57 | STK38 | 0.76243381 |
| 58 | STK11 | 0.75681240 |
| 59 | DYRK1A | 0.75660062 |
| 60 | CDK11A | 0.73372848 |
| 61 | BMPR2 | 0.72692222 |
| 62 | CAMK2B | 0.71255088 |
| 63 | MAPK12 | 0.69762034 |
| 64 | PTK2B | 0.68543380 |
| 65 | CDC42BPA | 0.68506898 |
| 66 | OXSR1 | 0.67996922 |
| 67 | CAMK1 | 0.67895055 |
| 68 | MARK2 | 0.66066968 |
| 69 | MAPK4 | 0.65479712 |
| 70 | PKN1 | 0.65288655 |
| 71 | SGK223 | 0.64608712 |
| 72 | SGK494 | 0.64608712 |
| 73 | FGR | 0.63929060 |
| 74 | RAF1 | 0.61016755 |
| 75 | AKT3 | 0.58947939 |
| 76 | PRKCZ | 0.58270075 |
| 77 | SGK1 | 0.58204125 |
| 78 | NME1 | 0.57481950 |
| 79 | ROCK1 | 0.54969847 |
| 80 | MAP3K6 | 0.54694463 |
| 81 | TAOK1 | 0.53429327 |
| 82 | PDPK1 | 0.53227442 |
| 83 | PRKCE | 0.51682771 |
| 84 | GRK7 | 0.50564197 |
| 85 | TYRO3 | 0.50357623 |
| 86 | SCYL2 | 0.50044334 |
| 87 | PDK1 | 0.49783253 |
| 88 | SGK2 | 0.49620755 |
| 89 | MAP4K2 | 0.49456103 |
| 90 | PRKACA | 0.46170918 |
| 91 | CSNK1G1 | 0.44044164 |
| 92 | CAMK1G | 0.43919083 |
| 93 | FYN | 0.43623903 |
| 94 | ABL2 | 0.43499915 |
| 95 | ADRBK2 | 0.42373942 |
| 96 | CAMK2D | 0.42328632 |
| 97 | MAP2K6 | 0.42044981 |
| 98 | ERBB3 | 0.41907457 |
| 99 | LMTK2 | 0.41488636 |
| 100 | PRKACB | 0.41272888 |
| 101 | SRC | 0.40723116 |
| 102 | MAP3K1 | 0.40364577 |
| 103 | PRKACG | 0.40101552 |
| 104 | MAP2K1 | 0.39663371 |
| 105 | PRKCH | 0.39365921 |
| 106 | PRKG1 | 0.39280252 |
| 107 | BRAF | 0.39200086 |
| 108 | FRK | 0.38461005 |
| 109 | DAPK3 | 0.37026488 |
| 110 | ROCK2 | 0.35800310 |
| 111 | RPS6KA3 | 0.35668485 |
| 112 | BCR | 0.34880799 |
| 113 | MAPKAPK5 | 0.34207303 |
| 114 | MAP3K5 | 0.33638687 |
| 115 | ADRBK1 | 0.33209118 |
| 116 | PRKCB | 0.32189742 |
| 117 | PRKCA | 0.32108874 |
| 118 | CAMK2G | 0.31004425 |
| 119 | SGK3 | 0.30448922 |
| 120 | PDK4 | 0.30404005 |
| 121 | PDK3 | 0.30404005 |
| 122 | PRKAA1 | 0.30323031 |
| 123 | STK24 | 0.30313459 |
| 124 | CSNK1A1L | 0.29789502 |
| 125 | WNK3 | 0.29618555 |
| 126 | GSK3B | 0.29103047 |
| 127 | FGFR1 | 0.28067047 |
| 128 | MAPK15 | 0.27609039 |
| 129 | CSNK1A1 | 0.27087498 |
| 130 | TRIM28 | 0.23939912 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.01590953 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.56599411 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.77779465 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 2.71410090 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.65917449 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.55783869 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.55776395 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.53010406 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 2.40449148 |
| 10 | Morphine addiction_Homo sapiens_hsa05032 | 2.39402311 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.30284867 |
| 12 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.26071996 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.22600102 |
| 14 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.92048908 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.90914285 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 1.88922081 |
| 17 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.87901215 |
| 18 | Long-term depression_Homo sapiens_hsa04730 | 1.87425461 |
| 19 | Renin secretion_Homo sapiens_hsa04924 | 1.84446136 |
| 20 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.83065037 |
| 21 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.81483777 |
| 22 | Cocaine addiction_Homo sapiens_hsa05030 | 1.81410186 |
| 23 | Taste transduction_Homo sapiens_hsa04742 | 1.79260058 |
| 24 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.71720269 |
| 25 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.70235528 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.66093223 |
| 27 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.59317593 |
| 28 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.53465791 |
| 29 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.47105230 |
| 30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.47069435 |
| 31 | Gap junction_Homo sapiens_hsa04540 | 1.46185215 |
| 32 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.44275786 |
| 33 | Axon guidance_Homo sapiens_hsa04360 | 1.41649050 |
| 34 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.37617967 |
| 35 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.33350753 |
| 36 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.22396034 |
| 37 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.22215126 |
| 38 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.14856664 |
| 39 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.14000211 |
| 40 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.13984087 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.13172272 |
| 42 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.12905810 |
| 43 | Sulfur relay system_Homo sapiens_hsa04122 | 1.10956793 |
| 44 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.08964213 |
| 45 | Phototransduction_Homo sapiens_hsa04744 | 1.06503702 |
| 46 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.05402532 |
| 47 | Glioma_Homo sapiens_hsa05214 | 1.05010780 |
| 48 | Melanogenesis_Homo sapiens_hsa04916 | 1.03599542 |
| 49 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.00181061 |
| 50 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.91342192 |
| 51 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.91230678 |
| 52 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.90410519 |
| 53 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.89517503 |
| 54 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.88425187 |
| 55 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.88355100 |
| 56 | Alzheimers disease_Homo sapiens_hsa05010 | 0.87225224 |
| 57 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.82072446 |
| 58 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.79024942 |
| 59 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.78422009 |
| 60 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.77508239 |
| 61 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.76436488 |
| 62 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.74767246 |
| 63 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.72190297 |
| 64 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.71065045 |
| 65 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.70119277 |
| 66 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.69543042 |
| 67 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.67162335 |
| 68 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.66459731 |
| 69 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.64974282 |
| 70 | Platelet activation_Homo sapiens_hsa04611 | 0.64545848 |
| 71 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.64219898 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.63582978 |
| 73 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.63211269 |
| 74 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.60165676 |
| 75 | Parkinsons disease_Homo sapiens_hsa05012 | 0.59816785 |
| 76 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.58220264 |
| 77 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.56353934 |
| 78 | Alcoholism_Homo sapiens_hsa05034 | 0.56229534 |
| 79 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.54130280 |
| 80 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.52958503 |
| 81 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.52486620 |
| 82 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50916272 |
| 83 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.49374921 |
| 84 | Endometrial cancer_Homo sapiens_hsa05213 | 0.49261394 |
| 85 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.48917665 |
| 86 | Prion diseases_Homo sapiens_hsa05020 | 0.47222221 |
| 87 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.46720246 |
| 88 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.45196184 |
| 89 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.41722875 |
| 90 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.41593892 |
| 91 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.38327154 |
| 92 | Circadian rhythm_Homo sapiens_hsa04710 | 0.38096467 |
| 93 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37756073 |
| 94 | Huntingtons disease_Homo sapiens_hsa05016 | 0.35127099 |
| 95 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.34931458 |
| 96 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.34926606 |
| 97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.34362036 |
| 98 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.33644738 |
| 99 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.32865687 |
| 100 | Colorectal cancer_Homo sapiens_hsa05210 | 0.32470289 |
| 101 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.31881872 |
| 102 | Endocytosis_Homo sapiens_hsa04144 | 0.31643346 |
| 103 | Bile secretion_Homo sapiens_hsa04976 | 0.31237184 |
| 104 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.30395904 |
| 105 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.29411208 |
| 106 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.28402016 |
| 107 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.27717621 |
| 108 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.27133291 |
| 109 | Phagosome_Homo sapiens_hsa04145 | 0.27082052 |
| 110 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.26870810 |
| 111 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.25764146 |
| 112 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.25642528 |
| 113 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.22481775 |
| 114 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.17735472 |
| 115 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.15197368 |
| 116 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.15071046 |
| 117 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.11421887 |
| 118 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.08963954 |
| 119 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.06616219 |
| 120 | ABC transporters_Homo sapiens_hsa02010 | 0.06114570 |
| 121 | Tight junction_Homo sapiens_hsa04530 | 0.05528037 |
| 122 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.04790237 |

