NXF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.48530814
2negative regulation of cell killing (GO:0031342)5.48530814
3ribosomal small subunit assembly (GO:0000028)4.47588019
4response to muramyl dipeptide (GO:0032495)4.36460889
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21277491
6response to peptidoglycan (GO:0032494)4.13029130
7tolerance induction (GO:0002507)4.11824597
8leukocyte aggregation (GO:0070486)4.07612486
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.96026856
10negative regulation of erythrocyte differentiation (GO:0045647)3.93512938
11regulation of B cell receptor signaling pathway (GO:0050855)3.87937976
12negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.81976762
13negative regulation of RNA splicing (GO:0033119)3.79219228
14response to interleukin-15 (GO:0070672)3.75949971
15histone H3-K4 trimethylation (GO:0080182)3.73593075
16detection of bacterium (GO:0016045)3.67932100
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.66733243
18modulation by symbiont of host immune response (GO:0052553)3.66733243
19positive regulation by symbiont of host defense response (GO:0052509)3.66733243
20modulation by symbiont of host defense response (GO:0052031)3.66733243
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66733243
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66733243
23detection of other organism (GO:0098543)3.64275383
24neutrophil activation involved in immune response (GO:0002283)3.62795732
25negative T cell selection (GO:0043383)3.61950571
26immunoglobulin mediated immune response (GO:0016064)3.58246722
27macrophage activation involved in immune response (GO:0002281)3.57545081
28negative regulation of T cell mediated immunity (GO:0002710)3.57149419
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.54863914
30negative regulation of interleukin-12 production (GO:0032695)3.54534955
31negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.48790254
32negative thymic T cell selection (GO:0045060)3.47848235
33viral transcription (GO:0019083)3.47104682
34negative regulation of mRNA processing (GO:0050686)3.43850295
35positive regulation of natural killer cell differentiation (GO:0032825)3.40241940
36germinal center formation (GO:0002467)3.38423539
37cellular response to interleukin-15 (GO:0071350)3.38107836
38histone H2A acetylation (GO:0043968)3.37941232
39positive regulation of gamma-delta T cell activation (GO:0046645)3.37653897
40defense response to protozoan (GO:0042832)3.36820800
41positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.36390852
42NIK/NF-kappaB signaling (GO:0038061)3.36116569
43translational termination (GO:0006415)3.33522144
44negative regulation of T-helper cell differentiation (GO:0045623)3.32207153
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.32207153
46DNA unwinding involved in DNA replication (GO:0006268)3.32081828
47positive thymic T cell selection (GO:0045059)3.26469772
48negative regulation of innate immune response (GO:0045824)3.25689637
49regulation of mast cell degranulation (GO:0043304)3.24842047
50positive regulation of B cell differentiation (GO:0045579)3.24700913
51cellular extravasation (GO:0045123)3.24528218
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24331241
53maturation of SSU-rRNA (GO:0030490)3.24135542
54negative regulation of leukocyte mediated immunity (GO:0002704)3.23367331
55alternative mRNA splicing, via spliceosome (GO:0000380)3.21096262
56positive regulation of interleukin-17 production (GO:0032740)3.21061772
57type I interferon signaling pathway (GO:0060337)3.18482148
58cellular response to type I interferon (GO:0071357)3.18482148
59response to type I interferon (GO:0034340)3.18367897
60response to protozoan (GO:0001562)3.15250958
61negative regulation of interleukin-6 production (GO:0032715)3.09937717
62ribosomal small subunit biogenesis (GO:0042274)3.09068676
63RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.06868859
64mRNA splicing, via spliceosome (GO:0000398)3.06868859
65regulation of alpha-beta T cell proliferation (GO:0046640)3.06080708
66T cell migration (GO:0072678)3.04170244
67RNA splicing, via transesterification reactions (GO:0000375)3.03225176
68pyrimidine dimer repair (GO:0006290)3.01930774
69termination of RNA polymerase II transcription (GO:0006369)3.01093182
70regulation of antigen processing and presentation (GO:0002577)3.00781710
71positive T cell selection (GO:0043368)3.00306237
72regulation of B cell differentiation (GO:0045577)2.98827981
73neutrophil activation (GO:0042119)2.98664333
74regulation of mast cell activation involved in immune response (GO:0033006)2.97382799
75regulation of tolerance induction (GO:0002643)2.97279909
76DNA strand elongation involved in DNA replication (GO:0006271)2.95657878
77B cell receptor signaling pathway (GO:0050853)2.94999829
78regulation of interferon-beta biosynthetic process (GO:0045357)2.94710365
79positive regulation of antigen processing and presentation (GO:0002579)2.94092730
80negative regulation of cytokine production involved in immune response (GO:0002719)2.93920065
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93876535
82regulation of natural killer cell mediated immunity (GO:0002715)2.93876535
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93262395
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91805545
85detection of external biotic stimulus (GO:0098581)2.91455631
86peptidyl-lysine trimethylation (GO:0018023)2.90528604
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89208955
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89208955
89CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.87670168
90cotranslational protein targeting to membrane (GO:0006613)2.87625601
91translational elongation (GO:0006414)2.87415047
92interferon-gamma-mediated signaling pathway (GO:0060333)2.87345180
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85189241
94negative regulation of mRNA metabolic process (GO:1903312)2.84461347
95antigen processing and presentation of endogenous antigen (GO:0019883)2.84455141
96myeloid cell activation involved in immune response (GO:0002275)2.84411901
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.83560323
98positive regulation of protein homooligomerization (GO:0032464)2.83024294
99CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.82820473
100T-helper cell differentiation (GO:0042093)2.82820473
101protein targeting to ER (GO:0045047)2.82697157
102granulocyte activation (GO:0036230)2.81172240
103negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80328084
104positive regulation of tolerance induction (GO:0002645)2.80085028
105DNA strand elongation (GO:0022616)2.79474178
106negative regulation of alpha-beta T cell activation (GO:0046636)2.79473065
107regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.79367996
108activated T cell proliferation (GO:0050798)2.79315112
109telomere maintenance via semi-conservative replication (GO:0032201)2.79238751
110regulation of regulatory T cell differentiation (GO:0045589)2.79173894
111positive regulation of histone H3-K4 methylation (GO:0051571)2.78576575
112B cell mediated immunity (GO:0019724)2.77478222
113regulation of T-helper 1 cell differentiation (GO:0045625)2.76961007
114positive regulation of interleukin-10 production (GO:0032733)2.76695635
115regulation of leukocyte degranulation (GO:0043300)2.76128789
116regulation of granulocyte differentiation (GO:0030852)2.75500363
117T cell selection (GO:0045058)2.74923238
118mannose metabolic process (GO:0006013)2.74389671
119histone H3-K4 methylation (GO:0051568)2.74125265
120regulation of gamma-delta T cell differentiation (GO:0045586)2.73231791
121V(D)J recombination (GO:0033151)2.73165464
122regulation of mast cell activation (GO:0033003)2.72751518
123establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71820953
124thymic T cell selection (GO:0045061)2.71718349
125mRNA splice site selection (GO:0006376)2.71299142
126negative regulation of adaptive immune response (GO:0002820)2.70613797
127translational initiation (GO:0006413)2.70160329
128macrophage activation (GO:0042116)2.68082449
129T cell homeostasis (GO:0043029)2.67881648
130viral life cycle (GO:0019058)2.67719894
131negative regulation of glycoprotein biosynthetic process (GO:0010561)2.67333880
132positive regulation of granulocyte differentiation (GO:0030854)2.66228934
1333-UTR-mediated mRNA stabilization (GO:0070935)2.65872009
134spliceosomal complex assembly (GO:0000245)2.64735788
135regulation of gamma-delta T cell activation (GO:0046643)2.64482468
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64175852
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.61768967
138protein localization to endoplasmic reticulum (GO:0070972)2.59021767
139mitotic recombination (GO:0006312)2.58777957
140cellular protein complex disassembly (GO:0043624)2.58618268
141telomere maintenance via recombination (GO:0000722)2.57488195
142ribosomal large subunit biogenesis (GO:0042273)2.53777344
143DNA topological change (GO:0006265)2.53645919
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52826640
145histone H3-K9 methylation (GO:0051567)2.52389682
146protein complex disassembly (GO:0043241)2.52152586
147regulation of mRNA splicing, via spliceosome (GO:0048024)2.51237584
148translesion synthesis (GO:0019985)2.50951573
149regulation of T cell tolerance induction (GO:0002664)2.50559869
150positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50001420
151nucleotide-excision repair, DNA gap filling (GO:0006297)2.49085703
152mRNA catabolic process (GO:0006402)2.49068599
153DNA demethylation (GO:0080111)2.48854900
154RNA splicing (GO:0008380)2.48429601
155DNA-templated transcription, termination (GO:0006353)2.46243508
156snRNA processing (GO:0016180)2.45816162
157* mRNA export from nucleus (GO:0006406)2.45741269
158* RNA export from nucleus (GO:0006405)2.45033424
159mismatch repair (GO:0006298)2.41897045
160negative regulation of histone methylation (GO:0031061)2.39873087
161histone H3-K9 modification (GO:0061647)2.38647047
162RNA catabolic process (GO:0006401)2.38548867
163regulation of histone H3-K27 methylation (GO:0061085)2.38141681
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37899477
165regulation of histone H3-K4 methylation (GO:0051569)2.37719559
166histone mRNA metabolic process (GO:0008334)2.37315429
167viral mRNA export from host cell nucleus (GO:0046784)2.36316790
168protein-DNA complex disassembly (GO:0032986)2.36307008
169nucleosome disassembly (GO:0006337)2.36307008
170DNA replication checkpoint (GO:0000076)2.36030726
171DNA replication initiation (GO:0006270)2.35852014
172kinetochore organization (GO:0051383)2.35644149
173regulation of RNA splicing (GO:0043484)2.34438669
174regulation of histone H3-K9 methylation (GO:0051570)2.33486883
175snRNA metabolic process (GO:0016073)2.33047362
176macromolecular complex disassembly (GO:0032984)2.32746096
177mitotic chromosome condensation (GO:0007076)2.30287269
178intra-S DNA damage checkpoint (GO:0031573)2.30056069
179DNA duplex unwinding (GO:0032508)2.29987827
180transcription elongation from RNA polymerase III promoter (GO:0006385)2.29400007
181termination of RNA polymerase III transcription (GO:0006386)2.29400007
182DNA geometric change (GO:0032392)2.28713630
183peptidyl-lysine methylation (GO:0018022)2.27488627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.99192656
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61544659
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.54727729
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29126527
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.22625234
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.02853565
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.02083468
8CIITA_25753668_ChIP-Seq_RAJI_Human3.00982922
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82782744
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.75911305
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72222595
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71718636
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.68684004
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.67575832
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53713142
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51995926
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49512869
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.46060176
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44872812
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40887823
21MYC_22102868_ChIP-Seq_BL_Human2.40825972
22* XRN2_22483619_ChIP-Seq_HELA_Human2.38001783
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28314588
24VDR_23849224_ChIP-Seq_CD4+_Human2.26298250
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25808151
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22870440
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.17695788
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17481964
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.15705175
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14587023
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13934120
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12826608
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12800490
34MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07173135
35* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06087645
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05120950
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04097589
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03359332
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03094414
40FOXP3_21729870_ChIP-Seq_TREG_Human2.02328977
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02160923
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00285517
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98591793
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93607577
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93217947
46KDM2B_26808549_Chip-Seq_DND41_Human1.90646759
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88272378
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.88005963
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86167855
50SPI1_23127762_ChIP-Seq_K562_Human1.85171219
51DCP1A_22483619_ChIP-Seq_HELA_Human1.84783398
52ELK1_19687146_ChIP-ChIP_HELA_Human1.80696885
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80028754
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78083150
55* TTF2_22483619_ChIP-Seq_HELA_Human1.78038787
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77120387
57* VDR_21846776_ChIP-Seq_THP-1_Human1.75021940
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.74971093
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74274986
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73965944
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73400690
62GATA3_27048872_Chip-Seq_THYMUS_Human1.73356402
63* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73007158
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70523009
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70369155
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69165317
67* GABP_19822575_ChIP-Seq_HepG2_Human1.66802408
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65112550
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64300491
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.62459640
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62211885
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58912652
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.58041307
74MYB_26560356_Chip-Seq_TH1_Human1.57887615
75SCL_19346495_ChIP-Seq_HPC-7_Human1.57692778
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56724991
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53997190
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53706111
79MYB_26560356_Chip-Seq_TH2_Human1.53415304
80MAF_26560356_Chip-Seq_TH1_Human1.49439850
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.49025025
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48543252
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48168751
84KDM5A_27292631_Chip-Seq_BREAST_Human1.45097617
85VDR_24787735_ChIP-Seq_THP-1_Human1.44945533
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43636575
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42378078
88* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41810312
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41784794
90GATA1_22025678_ChIP-Seq_K562_Human1.41681773
91* SPI1_23547873_ChIP-Seq_NB4_Human1.40576929
92* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38931322
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37716979
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.37506242
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.36480789
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36042936
97UTX_26944678_Chip-Seq_JUKART_Human1.35898170
98GATA3_26560356_Chip-Seq_TH2_Human1.35343210
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34592029
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.29799889
101LXR_22292898_ChIP-Seq_THP-1_Human1.28942955
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28721618
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28100021
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.27798077
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25400519
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23548655
107BCOR_27268052_Chip-Seq_Bcells_Human1.23170775
108MAF_26560356_Chip-Seq_TH2_Human1.22447723
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22065818
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22028100
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22015341
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.21787867
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21592602
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21241949
115* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20695416
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19831260
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19757351
118PU_27001747_Chip-Seq_BMDM_Mouse1.18519634
119BCL6_27268052_Chip-Seq_Bcells_Human1.18120681
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16266751
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16038354
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15514582
123CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15244255
124RUNX_20019798_ChIP-Seq_JUKART_Human1.14686563
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14659291
126* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14373048
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12914705
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11945651
129* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11053324
130ELF1_20517297_ChIP-Seq_JURKAT_Human1.10884668
131* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10016471
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09926889
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08588981
134* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06574347
135NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04687711
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03023027
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01504158
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00989633
139VDR_24763502_ChIP-Seq_THP-1_Human1.00618678
140GATA1_19941826_ChIP-Seq_K562_Human0.99856991
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99041783
142NCOR1_26117541_ChIP-Seq_K562_Human0.98139359
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98039338
144TFEB_21752829_ChIP-Seq_HELA_Human0.97369465
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96180715
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95453768
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94980820
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94375440
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94364179
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.93657898
151P68_20966046_ChIP-Seq_HELA_Human0.93080915
152* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93053971
153* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91963804
154IRF8_21731497_ChIP-ChIP_J774_Mouse0.91941033
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91603424
156AR_21909140_ChIP-Seq_LNCAP_Human0.90918831
157TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90011224
158CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89958062
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89663044
160TCF7_22412390_ChIP-Seq_EML_Mouse0.89364100
161GATA2_21666600_ChIP-Seq_HMVEC_Human0.88553530
162RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87972038
163STAT1_20625510_ChIP-Seq_HELA_Human0.86446851
164P300_27268052_Chip-Seq_Bcells_Human0.85927173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.29781310
2MP0003724_increased_susceptibility_to3.91399449
3MP0003763_abnormal_thymus_physiology3.54165477
4MP0008057_abnormal_DNA_replication3.44110217
5MP0003303_peritoneal_inflammation3.34093542
6MP0010094_abnormal_chromosome_stability3.19021617
7MP0002396_abnormal_hematopoietic_system2.78479552
8MP0003077_abnormal_cell_cycle2.75839082
9MP0008058_abnormal_DNA_repair2.72941686
10MP0002419_abnormal_innate_immunity2.71885289
11MP0009785_altered_susceptibility_to2.66123973
12MP0006082_CNS_inflammation2.55789525
13MP0008007_abnormal_cellular_replicative2.43810381
14MP0005671_abnormal_response_to2.39722685
15MP0003693_abnormal_embryo_hatching2.39372021
16MP0003111_abnormal_nucleus_morphology2.38785658
17MP0000685_abnormal_immune_system2.34518886
18MP0003172_abnormal_lysosome_physiology2.29801556
19MP0001835_abnormal_antigen_presentation2.13219002
20MP0001533_abnormal_skeleton_physiology2.12950664
21MP0000703_abnormal_thymus_morphology1.97740519
22MP0004947_skin_inflammation1.97614632
23MP0002398_abnormal_bone_marrow1.95000722
24MP0004957_abnormal_blastocyst_morpholog1.92503193
25MP0004808_abnormal_hematopoietic_stem1.91747677
26MP0002166_altered_tumor_susceptibility1.91442550
27MP0001873_stomach_inflammation1.90367933
28MP0001800_abnormal_humoral_immune1.83223795
29MP0003300_gastrointestinal_ulcer1.82053462
30MP0001790_abnormal_immune_system1.73912942
31MP0005387_immune_system_phenotype1.73912942
32MP0001845_abnormal_inflammatory_respons1.70152392
33MP0002420_abnormal_adaptive_immunity1.65671173
34MP0001819_abnormal_immune_cell1.64174657
35MP0003828_pulmonary_edema1.63512863
36MP0000716_abnormal_immune_system1.60975670
37MP0005464_abnormal_platelet_physiology1.60098999
38MP0001851_eye_inflammation1.57987723
39MP0002938_white_spotting1.57605398
40MP0009333_abnormal_splenocyte_physiolog1.57382060
41MP0002452_abnormal_antigen_presenting1.56676819
42MP0002722_abnormal_immune_system1.56591589
43MP0003121_genomic_imprinting1.56093131
44MP0005058_abnormal_lysosome_morphology1.55521862
45MP0002009_preneoplasia1.53984571
46MP0000569_abnormal_digit_pigmentation1.52765640
47MP0001853_heart_inflammation1.49446734
48MP0000689_abnormal_spleen_morphology1.48860888
49MP0008260_abnormal_autophagy1.46349165
50MP0004133_heterotaxia1.45223131
51MP0002723_abnormal_immune_serum1.44617861
52MP0000350_abnormal_cell_proliferation1.43793099
53MP0002429_abnormal_blood_cell1.42706492
54MP0008932_abnormal_embryonic_tissue1.42202532
55MP0009764_decreased_sensitivity_to1.41233858
56MP0008469_abnormal_protein_level1.41083515
57MP0003567_abnormal_fetal_cardiomyocyte1.40647114
58MP0003123_paternal_imprinting1.40511624
59MP0002998_abnormal_bone_remodeling1.39743574
60MP0003191_abnormal_cellular_cholesterol1.39527574
61MP0005174_abnormal_tail_pigmentation1.36314155
62MP0000566_synostosis1.35598512
63MP0000490_abnormal_crypts_of1.35485572
64MP0001293_anophthalmia1.32802011
65MP0003656_abnormal_erythrocyte_physiolo1.31342257
66MP0005000_abnormal_immune_tolerance1.24103856
67MP0002006_tumorigenesis1.22519351
68MP0008877_abnormal_DNA_methylation1.21527630
69MP0002163_abnormal_gland_morphology1.20574342
70MP0001730_embryonic_growth_arrest1.17836076
71MP0000313_abnormal_cell_death1.15324841
72MP0002405_respiratory_system_inflammati1.13698834
73MP0009840_abnormal_foam_cell1.12864612
74MP0002933_joint_inflammation1.12667651
75MP0005397_hematopoietic_system_phenotyp1.10079637
76MP0001545_abnormal_hematopoietic_system1.10079637
77MP0003122_maternal_imprinting1.07478296
78MP0005409_darkened_coat_color1.05391384
79MP0010155_abnormal_intestine_physiology1.03623148
80MP0000537_abnormal_urethra_morphology1.03413692
81MP0002138_abnormal_hepatobiliary_system1.03086223
82MP0005390_skeleton_phenotype1.02561144
83MP0000858_altered_metastatic_potential1.02185402
84MP0003984_embryonic_growth_retardation1.02158512
85MP0002132_abnormal_respiratory_system1.01737002
86MP0001672_abnormal_embryogenesis/_devel1.00805247
87MP0005380_embryogenesis_phenotype1.00805247
88MP0003786_premature_aging1.00137291
89MP0003787_abnormal_imprinting0.99413110
90MP0002277_abnormal_respiratory_mucosa0.99024315
91MP0002088_abnormal_embryonic_growth/wei0.98648291
92MP0002148_abnormal_hypersensitivity_rea0.97972459
93MP0010030_abnormal_orbit_morphology0.96890267
94MP0003943_abnormal_hepatobiliary_system0.96832224
95MP0005166_decreased_susceptibility_to0.96657916
96MP0009278_abnormal_bone_marrow0.95970976
97MP0000383_abnormal_hair_follicle0.95680070
98MP0001348_abnormal_lacrimal_gland0.95647130
99MP0005025_abnormal_response_to0.95247747
100MP0001697_abnormal_embryo_size0.94870888
101MP0002019_abnormal_tumor_incidence0.94710221
102MP0006292_abnormal_olfactory_placode0.94471241
103MP0008961_abnormal_basal_metabolism0.94103504
104MP0002084_abnormal_developmental_patter0.93719172
105MP0002085_abnormal_embryonic_tissue0.93689739
106MP0000015_abnormal_ear_pigmentation0.93345337
107MP0002095_abnormal_skin_pigmentation0.91080935
108MP0004510_myositis0.90795538
109MP0008789_abnormal_olfactory_epithelium0.90491481
110MP0002080_prenatal_lethality0.90439585
111MP0003075_altered_response_to0.88593113
112MP0002638_abnormal_pupillary_reflex0.88211798
113MP0004883_abnormal_blood_vessel0.87987618
114MP0002210_abnormal_sex_determination0.86481472
115MP0003866_abnormal_defecation0.86265659
116MP0005164_abnormal_response_to0.84648771
117MP0005075_abnormal_melanosome_morpholog0.84213626
118MP0003183_abnormal_peptide_metabolism0.83551581
119MP0001986_abnormal_taste_sensitivity0.82604274
120MP0005076_abnormal_cell_differentiation0.80445420
121MP0004381_abnormal_hair_follicle0.80023897
122MP0003795_abnormal_bone_structure0.77636154
123MP0002332_abnormal_exercise_endurance0.76127682
124MP0009763_increased_sensitivity_to0.75795032
125MP0001663_abnormal_digestive_system0.75752731
126MP0004197_abnormal_fetal_growth/weight/0.73951870
127MP0000428_abnormal_craniofacial_morphol0.73071180
128MP0000249_abnormal_blood_vessel0.72483701
129MP0003045_fibrosis0.71591149
130MP0003935_abnormal_craniofacial_develop0.71266777
131MP0003448_altered_tumor_morphology0.71226553
132MP0002932_abnormal_joint_morphology0.70995851
133MP0000465_gastrointestinal_hemorrhage0.70675949
134MP0005451_abnormal_body_composition0.70212846
135MP0001501_abnormal_sleep_pattern0.69579954
136MP0005310_abnormal_salivary_gland0.69491903
137MP0002086_abnormal_extraembryonic_tissu0.69393947
138MP0003119_abnormal_digestive_system0.68460701
139MP0001145_abnormal_male_reproductive0.66743718
140MP0009765_abnormal_xenobiotic_induced0.65942346
141MP0002092_abnormal_eye_morphology0.65876403
142MP0005394_taste/olfaction_phenotype0.65711474
143MP0005499_abnormal_olfactory_system0.65711474
144MP0001243_abnormal_dermal_layer0.65271970
145MP0001286_abnormal_eye_development0.65071517
146MP0008004_abnormal_stomach_pH0.64994192
147MP0004264_abnormal_extraembryonic_tissu0.61288253
148MP0002254_reproductive_system_inflammat0.56786975
149MP0009115_abnormal_fat_cell0.56548549
150MP0003690_abnormal_glial_cell0.55644757
151MP0003221_abnormal_cardiomyocyte_apopto0.55520929
152MP0000609_abnormal_liver_physiology0.52989569
153MP0005535_abnormal_body_temperature0.52206455
154MP0003091_abnormal_cell_migration0.51604452
155MP0002693_abnormal_pancreas_physiology0.50900393
156MP0009931_abnormal_skin_appearance0.50171291
157MP0005334_abnormal_fat_pad0.48274673

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.10234414
2Elevated erythrocyte sedimentation rate (HP:0003565)4.93007286
3Myositis (HP:0100614)4.71950493
4Stomatitis (HP:0010280)4.53441470
5Recurrent bacterial skin infections (HP:0005406)4.37744903
6Recurrent abscess formation (HP:0002722)4.27863654
7Orchitis (HP:0100796)4.03608258
8Retrobulbar optic neuritis (HP:0100654)4.01340710
9Optic neuritis (HP:0100653)4.01340710
10Abnormality of macrophages (HP:0004311)3.94086688
11Mediastinal lymphadenopathy (HP:0100721)3.64665869
12Reticulocytopenia (HP:0001896)3.62152612
13Abnormality of DNA repair (HP:0003254)3.57475737
14Panhypogammaglobulinemia (HP:0003139)3.56255743
15Increased IgE level (HP:0003212)3.50515337
16Vasculitis (HP:0002633)3.47181677
17Abnormality of the fingertips (HP:0001211)3.40938977
18Autoimmune hemolytic anemia (HP:0001890)3.40749450
19Meningitis (HP:0001287)3.37308984
20Gastrointestinal infarctions (HP:0005244)3.27085420
21Recurrent gram-negative bacterial infections (HP:0005420)3.22156112
22Recurrent skin infections (HP:0001581)3.22108283
23Pulmonary infiltrates (HP:0002113)3.19004435
24Chronic diarrhea (HP:0002028)3.14727144
25Pustule (HP:0200039)3.11345875
26Optic nerve coloboma (HP:0000588)3.04654887
27Keratoconjunctivitis sicca (HP:0001097)3.01251224
28Encephalitis (HP:0002383)2.98360783
29Prolonged bleeding time (HP:0003010)2.96776654
30Obstructive lung disease (HP:0006536)2.96776601
31Chronic obstructive pulmonary disease (HP:0006510)2.96776601
32Abnormality of B cell number (HP:0010975)2.87940662
33B lymphocytopenia (HP:0010976)2.87940662
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87762848
35Short 4th metacarpal (HP:0010044)2.87762848
36Ectopic kidney (HP:0000086)2.86341053
37Keratoconjunctivitis (HP:0001096)2.84822107
38Birth length less than 3rd percentile (HP:0003561)2.84702137
39Hemoptysis (HP:0002105)2.83383745
40Chronic otitis media (HP:0000389)2.80930582
41Hypergammaglobulinemia (HP:0010702)2.80060055
42Autoimmune thrombocytopenia (HP:0001973)2.79449787
43Colitis (HP:0002583)2.76385765
44Dysostosis multiplex (HP:0000943)2.72343551
45Abnormality of cells of the erythroid lineage (HP:0012130)2.69887501
46Loss of speech (HP:0002371)2.69821938
47Abnormal number of erythroid precursors (HP:0012131)2.68292681
48Severe combined immunodeficiency (HP:0004430)2.66049501
49Chest pain (HP:0100749)2.62927018
50Abnormality of T cell physiology (HP:0011840)2.62050237
51Recurrent viral infections (HP:0004429)2.61761364
52Increased IgM level (HP:0003496)2.59413302
53Chromsome breakage (HP:0040012)2.54552310
54Papilledema (HP:0001085)2.54346459
55Abnormal number of incisors (HP:0011064)2.50061281
56T lymphocytopenia (HP:0005403)2.45915412
57Epistaxis (HP:0000421)2.45879579
58IgM deficiency (HP:0002850)2.44940405
59Spontaneous hematomas (HP:0007420)2.44407414
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43222058
61Myelodysplasia (HP:0002863)2.42198645
62Abnormality of T cell number (HP:0011839)2.39064729
63Poikiloderma (HP:0001029)2.38087610
64Abnormality of the preputium (HP:0100587)2.37394423
65Urticaria (HP:0001025)2.36894759
66Gingivitis (HP:0000230)2.34925681
67Increased cerebral lipofuscin (HP:0011813)2.34347571
68Alveolar cell carcinoma (HP:0006519)2.34221520
69Systemic lupus erythematosus (HP:0002725)2.33204970
70Eosinophilia (HP:0001880)2.33085800
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.32278704
72Thrombocytosis (HP:0001894)2.32212968
73Arterial thrombosis (HP:0004420)2.31825204
74Abnormality of liposaccharide metabolism (HP:0010968)2.29398231
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.29398231
76Abnormality of glycolipid metabolism (HP:0010969)2.29398231
77Granulocytopenia (HP:0001913)2.26666161
78Meckel diverticulum (HP:0002245)2.26496450
79Cellulitis (HP:0100658)2.24094685
80Selective tooth agenesis (HP:0001592)2.22770700
81Pallor (HP:0000980)2.22565611
82Agammaglobulinemia (HP:0004432)2.20288880
83Stomach cancer (HP:0012126)2.20225922
84Hypochromic anemia (HP:0001931)2.18774512
85Abnormality of the ileum (HP:0001549)2.18754662
86Recurrent sinusitis (HP:0011108)2.18449080
87Osteomyelitis (HP:0002754)2.17395507
88Abnormal lung lobation (HP:0002101)2.16439297
89Aplastic anemia (HP:0001915)2.15913767
90Hypoplasia of the thymus (HP:0000778)2.15841660
91Restrictive lung disease (HP:0002091)2.15721836
92Episodic fever (HP:0001954)2.15006217
93Lymphoma (HP:0002665)2.13963013
94Recurrent bronchitis (HP:0002837)2.13473607
95Neoplasm of the tracheobronchial system (HP:0100552)2.13335033
96Increased serum ferritin (HP:0003281)2.12072041
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11566227
98Abnormality of polysaccharide metabolism (HP:0011012)2.11566227
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11566227
100Abnormality of chromosome stability (HP:0003220)2.11301955
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.11224980
102Abnormality of the pleura (HP:0002103)2.10452871
103Asplenia (HP:0001746)2.09205871
104Gingival bleeding (HP:0000225)2.05937182
105Abnormality of eosinophils (HP:0001879)2.05891582
106Basal cell carcinoma (HP:0002671)2.05576402
107Combined immunodeficiency (HP:0005387)2.05548031
108Emphysema (HP:0002097)2.04888016
109IgG deficiency (HP:0004315)2.04753537
110Trigonocephaly (HP:0000243)2.03988332
111Gangrene (HP:0100758)2.03863925
112Recurrent fungal infections (HP:0002841)2.03172629
113Abnormality of T cells (HP:0002843)2.02852554
114Anorexia (HP:0002039)2.02417991
115Petechiae (HP:0000967)2.01757193
116Malnutrition (HP:0004395)2.01741577
117Abnormality of the parietal bone (HP:0002696)2.01406565
118Pulmonary embolism (HP:0002204)2.00532270
119Small intestinal stenosis (HP:0012848)2.00445247
120Duodenal stenosis (HP:0100867)2.00445247
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99433029
122Aplasia/Hypoplasia of the spleen (HP:0010451)1.97724826
123Thyroiditis (HP:0100646)1.97455313
124Joint swelling (HP:0001386)1.96344085
125Duplicated collecting system (HP:0000081)1.95515528
126Fatigue (HP:0012378)1.95371275
127Amyloidosis (HP:0011034)1.95127793
128Colon cancer (HP:0003003)1.94865400
129Supernumerary spleens (HP:0009799)1.94339797
130Abnormality of iron homeostasis (HP:0011031)1.94214302
13111 pairs of ribs (HP:0000878)1.91999588
132Amaurosis fugax (HP:0100576)1.91956946
133Lymphopenia (HP:0001888)1.91833310
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.90521521
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.87967975
136Abnormality of the 4th metacarpal (HP:0010012)1.87191039
137Anal stenosis (HP:0002025)1.86149841
138Abnormality of the renal collecting system (HP:0004742)1.84437849
139Abnormality of the carotid arteries (HP:0005344)1.84351547
140Gastrointestinal inflammation (HP:0004386)1.82348748
141Aplasia/Hypoplasia of the thymus (HP:0010515)1.79066269
142Macrocytic anemia (HP:0001972)1.78927440
143Medulloblastoma (HP:0002885)1.78240962
144Inflammation of the large intestine (HP:0002037)1.75208510
145Prominent nose (HP:0000448)1.73888538
146Recurrent cutaneous fungal infections (HP:0011370)1.73785851
147Chronic mucocutaneous candidiasis (HP:0002728)1.73785851
148Overriding aorta (HP:0002623)1.72791461
149Cellular immunodeficiency (HP:0005374)1.72635536
150Bone marrow hypocellularity (HP:0005528)1.71757536
151Anteriorly placed anus (HP:0001545)1.70656056
152Hypoplastic pelvis (HP:0008839)1.66316775
153Triphalangeal thumb (HP:0001199)1.65833465
154Renal duplication (HP:0000075)1.64623743
155Increased nuchal translucency (HP:0010880)1.64059208
156Abnormality of the columella (HP:0009929)1.63409775
157Abnormality of midbrain morphology (HP:0002418)1.63326986
158Molar tooth sign on MRI (HP:0002419)1.63326986
159Clubbing of toes (HP:0100760)1.62968774
160Bicuspid aortic valve (HP:0001647)1.62569355
161Entropion (HP:0000621)1.62351555
162Delayed closure of the anterior fontanelle (HP:0001476)1.61780574
163Depressed nasal tip (HP:0000437)1.60674853
164Leukocytosis (HP:0001974)1.60626150
165Sloping forehead (HP:0000340)1.60359656
166Long clavicles (HP:0000890)1.58514529
167Gastrointestinal stroma tumor (HP:0100723)1.57925993
168Cheilitis (HP:0100825)1.57445325
169Limited elbow extension (HP:0001377)1.56056776
170Skin tags (HP:0010609)1.55179703
171Neoplasm of the oral cavity (HP:0100649)1.54569556
172Abnormality of the intervertebral disk (HP:0005108)1.53676791
173Ureteral stenosis (HP:0000071)1.53575619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FES4.13550183
2MAP4K13.52421089
3RIPK42.98516204
4CDK122.95835796
5PRPF4B2.77174282
6TAOK32.73176757
7CLK12.57185371
8BRD42.47530975
9SRPK12.44076570
10BUB12.30008518
11ERN12.29954443
12SIK32.29829833
13PASK2.25115063
14JAK32.18481953
15MKNK12.18002258
16TNK22.15224481
17BLK2.15182267
18MKNK22.10045646
19ATR1.86580929
20CDC71.86258264
21TXK1.80753140
22ZAP701.77992349
23STK161.69809712
24CSK1.68734240
25WEE11.67490493
26NLK1.66783144
27NEK21.64146209
28ITK1.61359966
29BTK1.59768341
30MAP3K141.56946998
31MAP3K31.55106456
32MAP3K101.43532178
33EIF2AK31.37673788
34TYK21.33456149
35ACVR1B1.29306280
36EIF2AK11.28106911
37TSSK61.26054327
38SIK21.25151937
39VRK11.21439221
40IRAK41.20516230
41RPS6KA41.19180408
42DYRK31.17460020
43YES11.16416970
44BMPR21.15122506
45STK101.13846210
46TAOK11.13025700
47FER1.11295040
48MAP3K131.10163433
49HIPK21.09011003
50LCK1.08769086
51IKBKB1.08037728
52CHUK1.06269000
53FGFR21.05317527
54TNIK1.04516176
55IKBKE1.03729856
56CDC42BPA1.03591856
57JAK21.01117798
58MARK21.00342915
59MAP2K20.99760155
60CSF1R0.98227198
61CDK70.97669430
62CHEK10.96532562
63BCR0.94755238
64FGFR40.93525640
65EIF2AK20.93446055
66AURKB0.92193932
67TAOK20.91909175
68TESK20.91388374
69TGFBR10.91112317
70MAP3K110.90257821
71STK40.88557095
72MAPK70.88538987
73MATK0.86783170
74PRKD20.86372618
75FGR0.85603439
76ZAK0.85449677
77SYK0.84357338
78PLK40.82240384
79CDK40.81069597
80TEC0.80136889
81TLK10.77615691
82PDK10.77468482
83FGFR10.76998111
84PLK10.76675242
85TRIB30.75168983
86TTK0.74987951
87KDR0.74882852
88CHEK20.73845689
89ATM0.73433633
90RPS6KB20.73385532
91MAP3K70.71974138
92MAP3K10.71949852
93CCNB10.71431737
94KIT0.70169964
95FGFR30.69641223
96FLT30.68976570
97MARK30.67605180
98MAPK110.65724203
99LYN0.65467055
100RIPK10.64058038
101MAP2K30.62495953
102CDK20.62049265
103EEF2K0.61404269
104MELK0.59961194
105RPS6KA50.59913970
106NME20.59452900
107RPS6KL10.59217050
108RPS6KC10.59217050
109KSR20.59200922
110UHMK10.58997508
111TGFBR20.58011972
112BRSK20.57629450
113JAK10.57445563
114MAP2K60.57296071
115MAPK150.57138213
116EPHB10.56962477
117PDPK10.56517984
118MAPK120.56292278
119GRK70.56288624
120PRKCQ0.54755332
121DYRK1B0.53740747
122CDK60.53488448
123CDK80.52219129
124HCK0.51960663
125MAP3K80.51354981
126TBK10.51254547
127CSNK1A1L0.49588017
128CDK90.49144850
129NUAK10.47924554
130IRAK20.47737440
131RPS6KA60.47468911
132CDK10.47014936
133IRAK30.44720883
134PDGFRB0.43937443
135ERBB30.43406092
136NEK60.43138301
137SGK30.42609813
138IRAK10.42410186
139PIM10.41739251
140GRK60.41608413
141SIK10.41365320
142CSNK2A20.41250229
143MAPKAPK20.40486186
144SMG10.40390015
145MAP3K50.39789384
146MAPK30.39741724
147EPHA30.39328811
148BMX0.38717987
149PRKAA20.37023870
150RPS6KA20.34641138
151CAMK10.33037124
152MTOR0.32112603
153RPS6KA10.31488252
154TRPM70.30023166
155FYN0.29497193
156LRRK20.28213259

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.36303778
2DNA replication_Homo sapiens_hsa030303.11259845
3Ribosome_Homo sapiens_hsa030102.95814913
4Mismatch repair_Homo sapiens_hsa034302.88971338
5Primary immunodeficiency_Homo sapiens_hsa053402.86460133
6Non-homologous end-joining_Homo sapiens_hsa034502.69333661
7RNA polymerase_Homo sapiens_hsa030202.51447694
8Homologous recombination_Homo sapiens_hsa034402.46953961
9Base excision repair_Homo sapiens_hsa034102.42937564
10Staphylococcus aureus infection_Homo sapiens_hsa051502.30282625
11Nucleotide excision repair_Homo sapiens_hsa034202.07418932
12* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07270223
13Fanconi anemia pathway_Homo sapiens_hsa034602.05479017
14Cell cycle_Homo sapiens_hsa041102.03481494
15Type I diabetes mellitus_Homo sapiens_hsa049401.93695148
16* RNA transport_Homo sapiens_hsa030131.93164593
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85700482
18* mRNA surveillance pathway_Homo sapiens_hsa030151.81862811
19Basal transcription factors_Homo sapiens_hsa030221.76012624
20* Herpes simplex infection_Homo sapiens_hsa051681.75581377
21Tuberculosis_Homo sapiens_hsa051521.73120611
22Proteasome_Homo sapiens_hsa030501.73029174
23RNA degradation_Homo sapiens_hsa030181.68512813
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.67789839
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.59633893
26Pyrimidine metabolism_Homo sapiens_hsa002401.56463281
27Measles_Homo sapiens_hsa051621.51976767
28Antigen processing and presentation_Homo sapiens_hsa046121.50249637
29Malaria_Homo sapiens_hsa051441.48668458
30T cell receptor signaling pathway_Homo sapiens_hsa046601.45115492
31Epstein-Barr virus infection_Homo sapiens_hsa051691.42671033
32Protein export_Homo sapiens_hsa030601.38577494
33One carbon pool by folate_Homo sapiens_hsa006701.37739309
34p53 signaling pathway_Homo sapiens_hsa041151.32661526
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32255841
36Pertussis_Homo sapiens_hsa051331.29486469
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23481437
38Autoimmune thyroid disease_Homo sapiens_hsa053201.20420788
39Rheumatoid arthritis_Homo sapiens_hsa053231.19408358
40Notch signaling pathway_Homo sapiens_hsa043301.19134557
41Hematopoietic cell lineage_Homo sapiens_hsa046401.18522680
42HTLV-I infection_Homo sapiens_hsa051661.14016541
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12683804
44Allograft rejection_Homo sapiens_hsa053301.10759143
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07406944
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04458958
47B cell receptor signaling pathway_Homo sapiens_hsa046621.04047953
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00686641
49Viral myocarditis_Homo sapiens_hsa054160.96889865
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.96539869
51African trypanosomiasis_Homo sapiens_hsa051430.95969692
52Lysosome_Homo sapiens_hsa041420.91309676
53Basal cell carcinoma_Homo sapiens_hsa052170.88574499
54Viral carcinogenesis_Homo sapiens_hsa052030.88455776
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88196799
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87925086
57Hepatitis B_Homo sapiens_hsa051610.86915189
58Non-small cell lung cancer_Homo sapiens_hsa052230.86222969
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.85936805
60Purine metabolism_Homo sapiens_hsa002300.85755694
61Small cell lung cancer_Homo sapiens_hsa052220.85194529
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84360063
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84321130
64Dorso-ventral axis formation_Homo sapiens_hsa043200.83964661
65Prolactin signaling pathway_Homo sapiens_hsa049170.82337422
66Leishmaniasis_Homo sapiens_hsa051400.82020970
67* Influenza A_Homo sapiens_hsa051640.80700666
68FoxO signaling pathway_Homo sapiens_hsa040680.80500718
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.77090522
70MicroRNAs in cancer_Homo sapiens_hsa052060.77008691
71Phagosome_Homo sapiens_hsa041450.76386385
72VEGF signaling pathway_Homo sapiens_hsa043700.75532752
73Apoptosis_Homo sapiens_hsa042100.74267851
74Chronic myeloid leukemia_Homo sapiens_hsa052200.73552547
75Graft-versus-host disease_Homo sapiens_hsa053320.73048944
76Shigellosis_Homo sapiens_hsa051310.73006269
77Lysine degradation_Homo sapiens_hsa003100.71871835
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70485881
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.69843895
80Salmonella infection_Homo sapiens_hsa051320.69460870
81Colorectal cancer_Homo sapiens_hsa052100.68864382
82Osteoclast differentiation_Homo sapiens_hsa043800.66751144
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65659508
84Insulin resistance_Homo sapiens_hsa049310.65605986
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62894028
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.62608424
87Choline metabolism in cancer_Homo sapiens_hsa052310.62080381
88Regulation of autophagy_Homo sapiens_hsa041400.60970930
89TNF signaling pathway_Homo sapiens_hsa046680.60835293
90MAPK signaling pathway_Homo sapiens_hsa040100.58794675
91Acute myeloid leukemia_Homo sapiens_hsa052210.58534330
92Toxoplasmosis_Homo sapiens_hsa051450.58408212
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.57266086
94Legionellosis_Homo sapiens_hsa051340.57232423
95Inositol phosphate metabolism_Homo sapiens_hsa005620.55767273
96Systemic lupus erythematosus_Homo sapiens_hsa053220.55389034
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.55074005
98Endocytosis_Homo sapiens_hsa041440.52840471
99N-Glycan biosynthesis_Homo sapiens_hsa005100.52505357
100Pathways in cancer_Homo sapiens_hsa052000.52499556
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52356154
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51823567
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51769997
104Adherens junction_Homo sapiens_hsa045200.50901506
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.50491183
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50085924
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49091198
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48977773
109Chemokine signaling pathway_Homo sapiens_hsa040620.48635533
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47155095
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46254022
112Prostate cancer_Homo sapiens_hsa052150.45201723
113Renal cell carcinoma_Homo sapiens_hsa052110.44744016
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43601016
115mTOR signaling pathway_Homo sapiens_hsa041500.42759427
116GnRH signaling pathway_Homo sapiens_hsa049120.40487962
117TGF-beta signaling pathway_Homo sapiens_hsa043500.40169482
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40160228
119Asthma_Homo sapiens_hsa053100.39739869
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38796381
121Endometrial cancer_Homo sapiens_hsa052130.38778065
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38629318
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38190009
124Circadian rhythm_Homo sapiens_hsa047100.37578207
125Pancreatic cancer_Homo sapiens_hsa052120.37508768
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36152992
127Wnt signaling pathway_Homo sapiens_hsa043100.35559505
128Hepatitis C_Homo sapiens_hsa051600.34820975
129Amoebiasis_Homo sapiens_hsa051460.33826277
130Hippo signaling pathway_Homo sapiens_hsa043900.33411043
131Estrogen signaling pathway_Homo sapiens_hsa049150.32845245
132Selenocompound metabolism_Homo sapiens_hsa004500.32280880
133Other glycan degradation_Homo sapiens_hsa005110.32065789
134Hedgehog signaling pathway_Homo sapiens_hsa043400.31364149
135Oocyte meiosis_Homo sapiens_hsa041140.30988303
136Thyroid cancer_Homo sapiens_hsa052160.30983171
137Sulfur relay system_Homo sapiens_hsa041220.30159591
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26699728
139Type II diabetes mellitus_Homo sapiens_hsa049300.26330464
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26020373
141Glycerolipid metabolism_Homo sapiens_hsa005610.25017104
142Complement and coagulation cascades_Homo sapiens_hsa046100.24221322
143Huntingtons disease_Homo sapiens_hsa050160.23909867
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23908128
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23808033
146Platelet activation_Homo sapiens_hsa046110.23284125
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19891068

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