NXF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.61258841
2chromosome organization involved in meiosis (GO:0070192)9.10493625
3meiotic nuclear division (GO:0007126)8.59309964
4meiotic chromosome segregation (GO:0045132)8.54653147
5gonadal mesoderm development (GO:0007506)7.35716152
6male meiosis I (GO:0007141)7.20697641
7reciprocal DNA recombination (GO:0035825)6.60907078
8reciprocal meiotic recombination (GO:0007131)6.60907078
9gene silencing by RNA (GO:0031047)6.43742179
10positive regulation of meiosis (GO:0045836)6.42456487
11DNA methylation (GO:0006306)6.34794292
12DNA alkylation (GO:0006305)6.34794292
13meiotic cell cycle process (GO:1903046)6.16945210
14resolution of meiotic recombination intermediates (GO:0000712)6.16524099
15meiosis I (GO:0007127)6.11280054
16positive regulation of meiotic cell cycle (GO:0051446)5.96412061
17cilium or flagellum-dependent cell motility (GO:0001539)5.79439681
18oogenesis (GO:0048477)5.68032151
19DNA synthesis involved in DNA repair (GO:0000731)5.57038565
20chromosome condensation (GO:0030261)5.44381310
21attachment of spindle microtubules to kinetochore (GO:0008608)5.40690217
22nuclear pore organization (GO:0006999)5.10248096
23sperm motility (GO:0030317)5.04200849
24positive regulation of translational initiation (GO:0045948)4.96506243
25binding of sperm to zona pellucida (GO:0007339)4.93684973
26sister chromatid cohesion (GO:0007062)4.90643882
27axonemal dynein complex assembly (GO:0070286)4.88420459
28DNA methylation or demethylation (GO:0044728)4.87256665
29nuclear pore complex assembly (GO:0051292)4.85856638
30negative regulation of meiosis (GO:0045835)4.85520971
31heterochromatin organization (GO:0070828)4.80199909
32DNA replication checkpoint (GO:0000076)4.70637425
33sperm-egg recognition (GO:0035036)4.69479807
34homocysteine metabolic process (GO:0050667)4.65236838
35kinetochore organization (GO:0051383)4.62848418
36folic acid-containing compound biosynthetic process (GO:0009396)4.61208680
37gene silencing (GO:0016458)4.57203659
38acrosome reaction (GO:0007340)4.55587852
39rRNA methylation (GO:0031167)4.52094826
40spermatid development (GO:0007286)4.42556769
41kinetochore assembly (GO:0051382)4.40997501
42oocyte maturation (GO:0001556)4.37618609
43IMP biosynthetic process (GO:0006188)4.34718496
44motile cilium assembly (GO:0044458)4.23974429
45female gamete generation (GO:0007292)4.10364591
46oocyte development (GO:0048599)4.05743869
47chromatin remodeling at centromere (GO:0031055)4.04213494
48histone H3-K9 demethylation (GO:0033169)4.01958956
49cysteine metabolic process (GO:0006534)4.00982729
50DNA modification (GO:0006304)4.00136470
51mitotic chromosome condensation (GO:0007076)4.00016811
52centriole assembly (GO:0098534)3.96891224
53histone H4-K12 acetylation (GO:0043983)3.96285777
54regulation of double-strand break repair via homologous recombination (GO:0010569)3.91595405
55IMP metabolic process (GO:0046040)3.86122583
56regulation of meiosis (GO:0040020)3.85238442
57cell-cell recognition (GO:0009988)3.79107315
58rRNA modification (GO:0000154)3.78885800
59microtubule nucleation (GO:0007020)3.76150817
60sperm capacitation (GO:0048240)3.74176868
61ribosome biogenesis (GO:0042254)3.72675098
62microtubule polymerization or depolymerization (GO:0031109)3.70992827
63sex differentiation (GO:0007548)3.68474222
64fusion of sperm to egg plasma membrane (GO:0007342)3.65600989
65proteasome assembly (GO:0043248)3.63974674
66histone exchange (GO:0043486)3.62166474
67mitotic spindle assembly checkpoint (GO:0007094)3.56323737
68DNA replication-dependent nucleosome organization (GO:0034723)3.53648524
69DNA replication-dependent nucleosome assembly (GO:0006335)3.53648524
70protein K6-linked ubiquitination (GO:0085020)3.52880537
71regulation of translational fidelity (GO:0006450)3.52726449
72pore complex assembly (GO:0046931)3.52386601
73synapsis (GO:0007129)3.50586230
74spindle assembly checkpoint (GO:0071173)3.50523994
75chromosome organization (GO:0051276)3.49354635
76mitotic spindle checkpoint (GO:0071174)3.44484255
77purine nucleobase biosynthetic process (GO:0009113)3.42598629
78negative regulation of chromosome segregation (GO:0051985)3.40942954
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.39449140
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.39449140
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.39449140
82negative regulation of sister chromatid segregation (GO:0033046)3.39449140
83DNA replication-independent nucleosome organization (GO:0034724)3.34742551
84DNA replication-independent nucleosome assembly (GO:0006336)3.34742551
85mitotic sister chromatid segregation (GO:0000070)3.34031031
86multicellular organism reproduction (GO:0032504)3.33963120
87centriole replication (GO:0007099)3.33577318
88meiotic cell cycle (GO:0051321)3.33094208
89metaphase plate congression (GO:0051310)3.32883689
90nuclear division (GO:0000280)3.32141263
91regulation of centriole replication (GO:0046599)3.32020963
92germ cell development (GO:0007281)3.31608370
93epithelial cilium movement (GO:0003351)3.28696045
94CENP-A containing nucleosome assembly (GO:0034080)3.28577656
95positive regulation of male gonad development (GO:2000020)3.28438591
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27700785
97fertilization (GO:0009566)3.26737553
98regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25943402
99regulation of chromosome segregation (GO:0051983)3.25768641
100spermatid nucleus differentiation (GO:0007289)3.24323282
101gamete generation (GO:0007276)3.21675082
102regulation of double-strand break repair (GO:2000779)3.21103442
103mitotic sister chromatid cohesion (GO:0007064)3.20942583
104tetrahydrofolate metabolic process (GO:0046653)3.20123907
105spindle checkpoint (GO:0031577)3.19908171
106organic cation transport (GO:0015695)3.19187156
107DNA replication initiation (GO:0006270)3.17343834
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17172077
109diterpenoid biosynthetic process (GO:0016102)3.16233744
110mitotic metaphase plate congression (GO:0007080)3.14873734
111negative regulation of nuclear division (GO:0051784)3.12642501
112inner cell mass cell proliferation (GO:0001833)3.12557907
113regulation of mitotic sister chromatid separation (GO:0010965)3.12307560
114regulation of mitotic sister chromatid segregation (GO:0033047)3.12307560
115regulation of sister chromatid segregation (GO:0033045)3.12307560
116cilium movement (GO:0003341)3.12105884
117regulation of meiotic cell cycle (GO:0051445)3.11857873
118negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.08819819
119sister chromatid segregation (GO:0000819)3.08255637
120regulation of mitotic spindle checkpoint (GO:1903504)3.07312245
121regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07312245
122histone H4-K8 acetylation (GO:0043982)3.05206445
123histone H4-K5 acetylation (GO:0043981)3.05206445
124DNA unwinding involved in DNA replication (GO:0006268)3.03917433
125COPII vesicle coating (GO:0048208)3.03653354
126chromosome segregation (GO:0007059)3.02889621
127negative regulation of protein acetylation (GO:1901984)3.01308501
128male gamete generation (GO:0048232)3.01035429
129organelle fission (GO:0048285)3.00675638
130DNA strand elongation involved in DNA replication (GO:0006271)3.00509205
131spermatogenesis (GO:0007283)3.00478399
132negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.99783308
133snRNA processing (GO:0016180)2.99609150
134pteridine-containing compound biosynthetic process (GO:0042559)2.99147908
135mitotic nuclear envelope disassembly (GO:0007077)2.98522483
136single strand break repair (GO:0000012)2.97876523
137regulation of histone H3-K9 methylation (GO:0051570)2.92746541
138DNA conformation change (GO:0071103)2.92103347
139negative regulation of meiotic cell cycle (GO:0051447)2.91543843
140microtubule depolymerization (GO:0007019)2.90059726
141DNA packaging (GO:0006323)2.89849143
142L-serine metabolic process (GO:0006563)2.89498175
143regulation of DNA endoreduplication (GO:0032875)2.86911714
144nuclear envelope disassembly (GO:0051081)2.86513492
145membrane disassembly (GO:0030397)2.86513492
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85184600
147DNA strand elongation (GO:0022616)2.84320168
148regulation of cilium movement (GO:0003352)2.83458346
149protein polyglutamylation (GO:0018095)2.82996659
150reproduction (GO:0000003)2.82111661
151single fertilization (GO:0007338)2.78339691
152nucleobase biosynthetic process (GO:0046112)2.75843180
153folic acid-containing compound metabolic process (GO:0006760)2.75273779
154piRNA metabolic process (GO:0034587)16.2652283
155synaptonemal complex assembly (GO:0007130)13.9679474
156DNA methylation involved in gamete generation (GO:0043046)13.3766045
157synaptonemal complex organization (GO:0070193)12.7344638
158male meiosis (GO:0007140)10.0303536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.33595695
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.43428978
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.65133321
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.82337133
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17472430
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.35395886
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31863082
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31518348
9AR_21909140_ChIP-Seq_LNCAP_Human3.26616404
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25420477
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.07804820
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.71087075
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65066764
14VDR_22108803_ChIP-Seq_LS180_Human2.50930473
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42909200
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42335842
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.40650433
18MYCN_18555785_ChIP-Seq_MESCs_Mouse2.30855468
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30022252
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28211582
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27110184
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12737279
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10671440
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10671440
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10671440
26RNF2_27304074_Chip-Seq_NSC_Mouse2.10606482
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08732619
28* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.05229564
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97744632
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.96407798
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94297103
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85148321
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.84869455
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82423873
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77406022
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75832891
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75296343
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72351707
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67778059
40XRN2_22483619_ChIP-Seq_HELA_Human1.60040414
41VDR_23849224_ChIP-Seq_CD4+_Human1.59004116
42RUNX1_26923725_Chip-Seq_HPCs_Mouse1.56253111
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54958321
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53427202
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50086525
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48973115
47DCP1A_22483619_ChIP-Seq_HELA_Human1.48049410
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.46049724
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40387373
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40078437
51KDM5A_27292631_Chip-Seq_BREAST_Human1.39907572
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.38426823
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37776614
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.37162900
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36729289
56NCOR1_26117541_ChIP-Seq_K562_Human1.34394845
57FOXP3_21729870_ChIP-Seq_TREG_Human1.30327009
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.29725367
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29266753
60ZNF274_21170338_ChIP-Seq_K562_Hela1.29250507
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25014752
62GABP_19822575_ChIP-Seq_HepG2_Human1.22292908
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21789525
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.17369962
65ER_23166858_ChIP-Seq_MCF-7_Human1.16168071
66TTF2_22483619_ChIP-Seq_HELA_Human1.15769100
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15458381
68ELK1_19687146_ChIP-ChIP_HELA_Human1.12906763
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11317202
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11241281
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10517014
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05563289
73ETV1_20927104_ChIP-Seq_GIST48_Human1.05521591
74CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04969643
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04308410
76RBPJ_21746931_ChIP-Seq_IB4_Human1.03909777
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02997385
78GATA2_19941826_ChIP-Seq_K562_Human1.00407492
79MYC_18940864_ChIP-ChIP_HL60_Human1.00156411
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99745756
81TP63_19390658_ChIP-ChIP_HaCaT_Human0.99321708
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99215600
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97925502
84TFEB_21752829_ChIP-Seq_HELA_Human0.97506650
85RAC3_21632823_ChIP-Seq_H3396_Human0.96749430
86CIITA_25753668_ChIP-Seq_RAJI_Human0.96143264
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95464660
88CBP_20019798_ChIP-Seq_JUKART_Human0.95464660
89PHF8_20622853_ChIP-Seq_HELA_Human0.93869477
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93843960
91PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93547586
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92913248
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91164236
94EWS_26573619_Chip-Seq_HEK293_Human0.90155807
95GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89934609
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89695740
97GATA1_19941826_ChIP-Seq_K562_Human0.89397640
98ERG_20517297_ChIP-Seq_VCAP_Human0.88115233
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87874229
100REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87609260
101NCOR_22424771_ChIP-Seq_293T_Human0.87180134
102OCT4_20526341_ChIP-Seq_ESCs_Human0.86693548
103GATA6_21074721_ChIP-Seq_CACO-2_Human0.85087919
104FUS_26573619_Chip-Seq_HEK293_Human0.84200050
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83809355
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83543423
107ELF5_23300383_ChIP-Seq_T47D_Human0.82776859
108SRF_21415370_ChIP-Seq_HL-1_Mouse0.81782383
109OCT1_27270436_Chip-Seq_PROSTATE_Human0.81718488
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81421056
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80715938
112HOXB7_26014856_ChIP-Seq_BT474_Human0.80273602
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80225932
114YY1_21170310_ChIP-Seq_MESCs_Mouse0.80060943
115HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79264118
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78495258
117* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78365747
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.73164754
119* GATA3_21867929_ChIP-Seq_TH1_Mouse0.68002290
120GATA1_22025678_ChIP-Seq_K562_Human0.67231685
121TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65383221
122LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.64869034
123ZNF263_19887448_ChIP-Seq_K562_Human0.63007031
124OCT4_19829295_ChIP-Seq_ESCs_Human0.62192099
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.60447217
126CHD1_26751641_Chip-Seq_LNCaP_Human0.59750856
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.59536814
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.59025553
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.58805370
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.58793413
131SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.57781426
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.56172585
133E2F1_17053090_ChIP-ChIP_MCF-7_Human0.55871086
134* HTT_18923047_ChIP-ChIP_STHdh_Human0.55428460
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.52710172
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.52168725
137LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51990727
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.51819202
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.51587203
140CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.51562279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002210_abnormal_sex_determination4.73509386
2MP0010094_abnormal_chromosome_stability4.08800282
3MP0008058_abnormal_DNA_repair3.91932266
4* MP0001929_abnormal_gametogenesis3.87463626
5* MP0001145_abnormal_male_reproductive3.75780254
6MP0003123_paternal_imprinting3.73602725
7* MP0008995_early_reproductive_senescence3.40164862
8* MP0000653_abnormal_sex_gland3.37581154
9MP0008057_abnormal_DNA_replication3.19081916
10* MP0003698_abnormal_male_reproductive3.06461291
11* MP0003786_premature_aging3.04107395
12MP0003111_abnormal_nucleus_morphology2.96038182
13MP0000678_abnormal_parathyroid_gland2.67309845
14MP0003077_abnormal_cell_cycle2.55237468
15MP0003693_abnormal_embryo_hatching2.39646474
16MP0002132_abnormal_respiratory_system2.36052683
17MP0004957_abnormal_blastocyst_morpholog2.31213632
18MP0008877_abnormal_DNA_methylation12.6610202
19MP0004808_abnormal_hematopoietic_stem1.98493282
20MP0004147_increased_porphyrin_level1.89965595
21MP0005670_abnormal_white_adipose1.89311919
22MP0003121_genomic_imprinting1.82574087
23* MP0002161_abnormal_fertility/fecundity1.74166200
24MP0008007_abnormal_cellular_replicative1.74159167
25MP0005360_urolithiasis1.70923738
26MP0001119_abnormal_female_reproductive1.67611291
27MP0008932_abnormal_embryonic_tissue1.65690962
28MP0005451_abnormal_body_composition1.62935378
29MP0001730_embryonic_growth_arrest1.61155568
30MP0010352_gastrointestinal_tract_polyps1.60102695
31MP0005646_abnormal_pituitary_gland1.56307384
32MP0003890_abnormal_embryonic-extraembry1.55527903
33MP0010307_abnormal_tumor_latency1.48451455
34MP0000350_abnormal_cell_proliferation1.41364686
35MP0005083_abnormal_biliary_tract1.33323864
36MP0003646_muscle_fatigue1.32501722
37MP0001764_abnormal_homeostasis1.31766977
38MP0005410_abnormal_fertilization1.25802332
39MP0003950_abnormal_plasma_membrane1.25748961
40MP0008775_abnormal_heart_ventricle1.22867299
41MP0003787_abnormal_imprinting1.22811676
42MP0003878_abnormal_ear_physiology1.17077148
43MP0005377_hearing/vestibular/ear_phenot1.17077148
44MP0001502_abnormal_circadian_rhythm1.16470962
45MP0002009_preneoplasia1.14805771
46MP0003656_abnormal_erythrocyte_physiolo1.13400503
47MP0003699_abnormal_female_reproductive1.11640987
48MP0001348_abnormal_lacrimal_gland1.11344282
49MP0003186_abnormal_redox_activity1.02544213
50MP0005647_abnormal_sex_gland1.00798707
51MP0005395_other_phenotype1.00494802
52MP0003806_abnormal_nucleotide_metabolis1.00255041
53MP0000647_abnormal_sebaceous_gland0.99088023
54MP0005409_darkened_coat_color0.98233821
55MP0004197_abnormal_fetal_growth/weight/0.98209594
56MP0005076_abnormal_cell_differentiation0.98146849
57MP0009672_abnormal_birth_weight0.96900103
58MP0001697_abnormal_embryo_size0.96851668
59MP0000313_abnormal_cell_death0.96433120
60MP0006036_abnormal_mitochondrial_physio0.96294301
61MP0002160_abnormal_reproductive_system0.94466296
62MP0005332_abnormal_amino_acid0.93455562
63MP0001672_abnormal_embryogenesis/_devel0.93261681
64MP0005380_embryogenesis_phenotype0.93261681
65MP0002019_abnormal_tumor_incidence0.92748588
66MP0003705_abnormal_hypodermis_morpholog0.90477482
67MP0003984_embryonic_growth_retardation0.90417166
68MP0009115_abnormal_fat_cell0.89821966
69MP0005623_abnormal_meninges_morphology0.89194676
70MP0002396_abnormal_hematopoietic_system0.88876308
71MP0004019_abnormal_vitamin_homeostasis0.88174026
72MP0005636_abnormal_mineral_homeostasis0.84145354
73MP0002088_abnormal_embryonic_growth/wei0.83018161
74MP0002085_abnormal_embryonic_tissue0.82025203
75MP0006035_abnormal_mitochondrial_morpho0.81510164
76MP0004782_abnormal_surfactant_physiolog0.81147759
77MP0002249_abnormal_larynx_morphology0.79976555
78MP0001346_abnormal_lacrimal_gland0.76663181
79MP0002080_prenatal_lethality0.73572822
80MP0002084_abnormal_developmental_patter0.72456945
81MP0002095_abnormal_skin_pigmentation0.70494204
82MP0003941_abnormal_skin_development0.69902648
83MP0005376_homeostasis/metabolism_phenot0.66958517
84MP0002006_tumorigenesis0.66940928
85MP0005310_abnormal_salivary_gland0.65953767
86MP0001853_heart_inflammation0.65389513
87MP0002282_abnormal_trachea_morphology0.65179775
88MP0003936_abnormal_reproductive_system0.65028214
89MP0009703_decreased_birth_body0.64867167
90MP0003045_fibrosis0.64583920
91MP0008872_abnormal_physiological_respon0.64214954
92MP0000613_abnormal_salivary_gland0.64023387
93MP0000569_abnormal_digit_pigmentation0.62376595
94MP0003718_maternal_effect0.61231886
95MP0002086_abnormal_extraembryonic_tissu0.60610190
96MP0005645_abnormal_hypothalamus_physiol0.60217984
97MP0003221_abnormal_cardiomyocyte_apopto0.60148732
98MP0003315_abnormal_perineum_morphology0.58987808
99MP0002229_neurodegeneration0.57145204
100MP0000427_abnormal_hair_cycle0.56871876
101MP0005253_abnormal_eye_physiology0.55716733
102MP0005621_abnormal_cell_physiology0.55339462
103MP0000371_diluted_coat_color0.54804495
104MP0001915_intracranial_hemorrhage0.52784197
105MP0003567_abnormal_fetal_cardiomyocyte0.52526708
106MP0005379_endocrine/exocrine_gland_phen0.52107522
107MP0005164_abnormal_response_to0.51987858
108MP0005551_abnormal_eye_electrophysiolog0.51525192
109MP0005384_cellular_phenotype0.51281147
110MP0002166_altered_tumor_susceptibility0.51109700
111MP0004264_abnormal_extraembryonic_tissu0.50383554
112MP0005397_hematopoietic_system_phenotyp0.49553337
113MP0001545_abnormal_hematopoietic_system0.49553337
114MP0000703_abnormal_thymus_morphology0.49248467
115MP0001661_extended_life_span0.47135227
116MP0002269_muscular_atrophy0.45650903
117MP0000383_abnormal_hair_follicle0.44340271
118MP0005389_reproductive_system_phenotype0.41347956
119MP0009697_abnormal_copulation0.40071142
120MP0002075_abnormal_coat/hair_pigmentati0.39694874
121MP0003943_abnormal_hepatobiliary_system0.39391290
122MP0002089_abnormal_postnatal_growth/wei0.38716441
123MP0003119_abnormal_digestive_system0.37800022
124MP0005171_absent_coat_pigmentation0.36161770
125MP0001177_atelectasis0.34589093
126MP0004233_abnormal_muscle_weight0.34525564
127MP0001293_anophthalmia0.32848904
128MP0000537_abnormal_urethra_morphology0.31132110
129MP0009765_abnormal_xenobiotic_induced0.30602351
130MP0003937_abnormal_limbs/digits/tail_de0.30525858
131MP0003632_abnormal_nervous_system0.29903108
132MP0010678_abnormal_skin_adnexa0.29317218
133MP0009053_abnormal_anal_canal0.28940639
134MP0001727_abnormal_embryo_implantation0.28874848
135MP0006138_congestive_heart_failure0.26949462
136MP0009278_abnormal_bone_marrow0.26710023
137MP0003861_abnormal_nervous_system0.25788407
138MP0008873_increased_physiological_sensi0.24052688
139MP0002398_abnormal_bone_marrow0.23950096
140MP0003448_altered_tumor_morphology0.23893330
141MP0004036_abnormal_muscle_relaxation0.23419445
142MP0000689_abnormal_spleen_morphology0.22982749
143MP0003566_abnormal_cell_adhesion0.22830413
144MP0005408_hypopigmentation0.22489906
145MP0001186_pigmentation_phenotype0.22025091

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)7.01501867
2Gonadotropin excess (HP:0000837)5.32413141
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.67128780
4Absent/shortened dynein arms (HP:0200106)4.67128780
5Abnormal gallbladder physiology (HP:0012438)4.61362995
6Cholecystitis (HP:0001082)4.61362995
7Tubulointerstitial nephritis (HP:0001970)4.49886715
8Chromsome breakage (HP:0040012)4.15206717
9Abnormal respiratory motile cilium morphology (HP:0005938)4.13250650
10Abnormal respiratory epithelium morphology (HP:0012253)4.13250650
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.12036059
12Papillary thyroid carcinoma (HP:0002895)4.00214919
13Facial hemangioma (HP:0000329)3.86723809
14Abnormal respiratory motile cilium physiology (HP:0012261)3.86453265
15Upper motor neuron abnormality (HP:0002127)3.86252605
16Shoulder girdle muscle weakness (HP:0003547)3.85767740
17Abnormality of the labia minora (HP:0012880)3.80295915
18Abnormal ciliary motility (HP:0012262)3.79800011
19Chronic hepatic failure (HP:0100626)3.73619983
20Spontaneous abortion (HP:0005268)3.73336865
21Amyotrophic lateral sclerosis (HP:0007354)3.73081408
2211 pairs of ribs (HP:0000878)3.39618364
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35934826
24Ileus (HP:0002595)3.19938632
25Birth length less than 3rd percentile (HP:0003561)3.17561181
26Hand muscle atrophy (HP:0009130)3.16599526
27Carpal bone hypoplasia (HP:0001498)3.15600243
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.10571514
29Abnormality of alanine metabolism (HP:0010916)3.10571514
30Hyperalaninemia (HP:0003348)3.10571514
31Ankle contracture (HP:0006466)3.06617290
32Colon cancer (HP:0003003)3.04940808
33Capillary hemangiomas (HP:0005306)2.91819217
34Infertility (HP:0000789)2.91398547
35Breast hypoplasia (HP:0003187)2.90787589
36Esophageal varix (HP:0002040)2.86200367
37Impulsivity (HP:0100710)2.83394801
38Pelvic girdle muscle weakness (HP:0003749)2.80621119
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.78274415
40Reticulocytosis (HP:0001923)2.75619995
41Abnormality of chromosome stability (HP:0003220)2.70069213
42Rhinitis (HP:0012384)2.69840567
43Ectopic kidney (HP:0000086)2.68777230
44Abnormality of the fingertips (HP:0001211)2.65776016
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.64428834
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64314380
47Urethral obstruction (HP:0000796)2.62654675
48Occipital encephalocele (HP:0002085)2.59609196
49Hypoplasia of the uterus (HP:0000013)2.57301784
50Severe visual impairment (HP:0001141)2.54363907
51Progressive external ophthalmoplegia (HP:0000590)2.54112463
52Short tibia (HP:0005736)2.52323150
53Abnormality of the renal collecting system (HP:0004742)2.52210123
54Absent thumb (HP:0009777)2.52156634
55Limb-girdle muscle weakness (HP:0003325)2.52032009
56Shawl scrotum (HP:0000049)2.51645783
57Attenuation of retinal blood vessels (HP:0007843)2.50064688
58Abnormality of cochlea (HP:0000375)2.49591523
59Cholelithiasis (HP:0001081)2.47484575
60Cone-rod dystrophy (HP:0000548)2.47172112
61Bowel incontinence (HP:0002607)2.46219072
62Thyroid carcinoma (HP:0002890)2.45774119
63Volvulus (HP:0002580)2.45082718
64Fibular hypoplasia (HP:0003038)2.44768919
65Resting tremor (HP:0002322)2.44142876
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.43630891
67Abnormality of DNA repair (HP:0003254)2.43530872
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43364421
69Abnormality of the hip-girdle musculature (HP:0001445)2.40290596
70Abnormality of the musculature of the pelvis (HP:0001469)2.40290596
71Abnormal large intestine physiology (HP:0012700)2.39535595
72Upper limb amyotrophy (HP:0009129)2.38993583
73Distal upper limb amyotrophy (HP:0007149)2.38993583
74Tetraplegia (HP:0002445)2.37024604
75Rhabdomyosarcoma (HP:0002859)2.35544824
76Long eyelashes (HP:0000527)2.34681637
77Metaphyseal cupping (HP:0003021)2.31375659
78Chronic bronchitis (HP:0004469)2.31247151
79Spinal muscular atrophy (HP:0007269)2.31000568
80Cystic liver disease (HP:0006706)2.29209321
81Abnormality of reticulocytes (HP:0004312)2.28047160
82Obstructive sleep apnea (HP:0002870)2.24951857
83Duodenal stenosis (HP:0100867)2.24867064
84Small intestinal stenosis (HP:0012848)2.24867064
85Abnormality of the preputium (HP:0100587)2.24246082
86Abnormality of the aortic arch (HP:0012303)2.23013375
87Bronchiectasis (HP:0002110)2.23012333
88Selective tooth agenesis (HP:0001592)2.19603407
89Abnormal lung lobation (HP:0002101)2.19102044
90Sandal gap (HP:0001852)2.18210466
91Bony spicule pigmentary retinopathy (HP:0007737)2.18189778
92Abnormality of the anterior horn cell (HP:0006802)2.17993904
93Degeneration of anterior horn cells (HP:0002398)2.17993904
94Aplasia/hypoplasia of the uterus (HP:0008684)2.17782911
95Increased nuchal translucency (HP:0010880)2.16204706
96Aplasia/Hypoplasia of the tibia (HP:0005772)2.13445161
97Constricted visual fields (HP:0001133)2.12906385
98Patellar aplasia (HP:0006443)2.12712751
99Truncal obesity (HP:0001956)2.11482901
100Abnormal gallbladder morphology (HP:0012437)2.09657453
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.09294772
102Facial cleft (HP:0002006)2.08901652
103Medulloblastoma (HP:0002885)2.08741570
104Oligodactyly (HP:0012165)2.08391849
105Supernumerary spleens (HP:0009799)2.06571168
106Nasal polyposis (HP:0100582)2.06320400
107Glioma (HP:0009733)2.06307987
108Arteriovenous malformation (HP:0100026)2.06235981
109Ependymoma (HP:0002888)2.05464863
110Heterotopia (HP:0002282)2.02885138
111Truncus arteriosus (HP:0001660)2.02506230
112Hypoparathyroidism (HP:0000829)2.01700666
113Polycythemia (HP:0001901)2.00210001
114Abnormal umbilical cord blood vessels (HP:0011403)2.00202978
115Single umbilical artery (HP:0001195)2.00202978
116Abnormality of the fetal cardiovascular system (HP:0010948)2.00202978
117Azoospermia (HP:0000027)12.7780574
118Abnormal spermatogenesis (HP:0008669)10.9679225
119Cutaneous melanoma (HP:0012056)1.99238538
120Sloping forehead (HP:0000340)1.99164047
121Pancreatic cysts (HP:0001737)1.98563806
122Broad palm (HP:0001169)1.98463465
123Meckel diverticulum (HP:0002245)1.98190625
124Abnormality of the musculature of the hand (HP:0001421)1.97759258
125Abnormality of the ileum (HP:0001549)1.94708583
126Duplicated collecting system (HP:0000081)1.93366794
127Abnormality of the corticospinal tract (HP:0002492)1.93068294
128Homocystinuria (HP:0002156)1.92086192
129Abnormality of homocysteine metabolism (HP:0010919)1.92086192
130Abnormality of the phalanges of the hallux (HP:0010057)1.91983282
131Abnormality of the nasal septum (HP:0000419)1.91326460
132Fatigue (HP:0012378)1.91322592
133Relative macrocephaly (HP:0004482)1.91302465
134Hyperuricemia (HP:0002149)1.91107556
135Increased purine levels (HP:0004368)1.91107556
136Oligodactyly (hands) (HP:0001180)1.90688785
137Abnormal biliary tract morphology (HP:0012440)1.90582597
138Astrocytoma (HP:0009592)1.90573290
139Abnormality of the astrocytes (HP:0100707)1.90573290
140Aplasia/Hypoplasia of the patella (HP:0006498)1.89185817
141Flattened epiphyses (HP:0003071)1.88473071
142Short thumb (HP:0009778)1.87053057
143Proximal placement of thumb (HP:0009623)1.86115319
144Portal hypertension (HP:0001409)1.85111745
145Hypoplastic pelvis (HP:0008839)1.84981359
146Pancreatic fibrosis (HP:0100732)1.84133442
147Male pseudohermaphroditism (HP:0000037)1.84006356
148Wrist flexion contracture (HP:0001239)1.83746043
149Male infertility (HP:0003251)1.83662401
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81376951
151Decreased subcutaneous fat (HP:0001002)1.80921458
152Absent radius (HP:0003974)1.80852280
153Atelectasis (HP:0100750)1.79793263
154Low anterior hairline (HP:0000294)1.79571803
155Rimmed vacuoles (HP:0003805)1.79454326
156Abnormal neuron morphology (HP:0012757)1.78965004
157Abnormality of the motor neurons (HP:0002450)1.78965004
158External ophthalmoplegia (HP:0000544)1.78542665
159Gonadal dysgenesis (HP:0000133)1.78123487
160Abnormality of chromosome segregation (HP:0002916)1.78098649
161Subcapsular cataract (HP:0000523)1.77738695
162Seborrheic dermatitis (HP:0001051)1.77243721
163Neoplasm of striated muscle (HP:0009728)1.77222300
164Abnormality of the gallbladder (HP:0005264)1.77027408
165Abnormality of the hepatic vasculature (HP:0006707)1.76843270
166Horizontal nystagmus (HP:0000666)1.76257739
167Biliary tract neoplasm (HP:0100574)1.75683369
168Tinnitus (HP:0000360)1.75585888
169Paralysis (HP:0003470)1.75524997
170Myocardial infarction (HP:0001658)1.75256536
171Horseshoe kidney (HP:0000085)1.74883393
172Aplasia involving forearm bones (HP:0009822)1.74650611
173Absent forearm bone (HP:0003953)1.74650611
174Intellectual disability, moderate (HP:0002342)1.74205369
175Cafe-au-lait spot (HP:0000957)1.73796906
176Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72999833
177Myelodysplasia (HP:0002863)1.72952437
178Nephronophthisis (HP:0000090)1.72829321
179Congenital sensorineural hearing impairment (HP:0008527)1.72798038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.72934312
2CDC76.17411255
3CDK125.34330739
4PNCK3.91890523
5TRIM282.92768747
6WEE12.78682958
7PBK2.64146603
8NEK22.63991745
9BRSK22.48698476
10NEK12.38901893
11SIK32.36066121
12MET2.35260814
13BRD42.29485871
14WNK42.22364239
15PLK12.04550193
16MST1R1.99305234
17IRAK31.93877883
18MST41.91333316
19PDK31.88691484
20PDK41.88691484
21STK391.86381248
22PLK41.79835363
23OXSR11.72919854
24ATR1.66846200
25NTRK31.63628583
26CHEK11.61381909
27BRSK11.56763844
28BMPR1B1.50116244
29FGR1.49775558
30BUB11.47725221
31TTK1.45757399
32CDK71.44593232
33CDK81.44281069
34KSR21.43891365
35TGFBR11.38316924
36MELK1.36922105
37CAMK1G1.36822022
38ATM1.35129516
39MAP3K41.29150091
40EEF2K1.28150721
41STK241.27424772
42BMX1.27049046
43STK38L1.25273578
44MAP3K21.22897669
45NEK61.18940640
46PLK31.17044821
47MKNK21.16421298
48CDC42BPA1.15839564
49INSRR1.10686091
50PLK21.08090256
51MKNK11.07630047
52STK41.07292610
53CHEK21.00648858
54MAPK150.97461121
55AURKB0.95963613
56CAMK1D0.91443092
57CDK20.90830841
58PKN20.89942352
59PDK20.88214986
60CLK10.87656046
61IRAK20.86854342
62STK30.86306585
63TRPM70.85580852
64CDK10.84315483
65CDK90.84166281
66SRPK10.83395043
67DYRK30.81224984
68IRAK10.80384874
69TYRO30.76323885
70BMPR20.76213717
71WNK30.74472672
72MAP3K80.72940484
73ZAK0.72678598
74CCNB10.72521612
75MINK10.69689798
76CDK40.67763174
77BRAF0.66909983
78RAF10.65221937
79JAK30.65013725
80RET0.64902269
81EIF2AK10.63489945
82LATS10.62897247
83MAP3K90.61536693
84MUSK0.60195463
85PAK40.55953673
86SCYL20.55233609
87PRKDC0.54284750
88MARK30.53765466
89AKT30.52820331
90RIPK10.51317709
91MTOR0.51269090
92STK380.50963524
93PASK0.50833653
94LIMK10.49668521
95PIK3CG0.48844006
96JAK20.46672245
97GSK3B0.46081733
98MAP3K30.45888111
99ICK0.45565170
100TESK10.44912352
101BCR0.44891475
102RIPK40.44491804
103PRKD30.44230003
104SIK10.43552525
105SGK30.43341955
106EIF2AK30.42146275
107AURKA0.41926031
108CSNK2A20.41714972
109STK160.41582424
110TSSK60.40760167
111MAPK80.40384265
112ERBB30.40175560
113CSNK1A1L0.39911262
114YES10.39809177
115CHUK0.39327945
116IRAK40.39246773
117SGK20.38947664
118PRKCI0.37678323
119MAP3K60.37076141
120CSNK1D0.36918302
121NME10.36196663
122SGK10.35740054
123PTK2B0.33714210
124EGFR0.33637066
125RPS6KB10.32866345
126SGK4940.31790765
127SGK2230.31790765
128MAPK110.31448401
129CSNK2A10.30845662
130MARK10.30242449
131VRK10.29747657
132MAPK140.29579917
133ALK0.29266823
134DYRK1A0.29112412
135CSNK1E0.28389356
136RPS6KB20.27886360
137KSR10.27649815
138PINK10.27424522
139MAP2K20.26127840
140FLT30.25749991
141CSNK1G20.24382487
142MAPK70.24155519
143CSNK1G10.23710605
144AKT10.21200573

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.17763634
2Basal transcription factors_Homo sapiens_hsa030225.13816405
3Homologous recombination_Homo sapiens_hsa034404.36096396
4DNA replication_Homo sapiens_hsa030303.99874663
5Cell cycle_Homo sapiens_hsa041103.62206616
6Mismatch repair_Homo sapiens_hsa034303.58443138
7RNA polymerase_Homo sapiens_hsa030203.32166086
8Proteasome_Homo sapiens_hsa030502.95903445
9Non-homologous end-joining_Homo sapiens_hsa034502.95292659
10* RNA transport_Homo sapiens_hsa030132.94015560
11Spliceosome_Homo sapiens_hsa030402.82248749
12Fanconi anemia pathway_Homo sapiens_hsa034602.62203941
13Nucleotide excision repair_Homo sapiens_hsa034202.59651208
14* mRNA surveillance pathway_Homo sapiens_hsa030152.32695388
15Base excision repair_Homo sapiens_hsa034102.19817465
16RNA degradation_Homo sapiens_hsa030182.12921401
17Oocyte meiosis_Homo sapiens_hsa041142.09857653
18Selenocompound metabolism_Homo sapiens_hsa004502.08282008
19One carbon pool by folate_Homo sapiens_hsa006702.04739398
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.02430291
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88881433
22Pyrimidine metabolism_Homo sapiens_hsa002401.79477943
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74215084
24Olfactory transduction_Homo sapiens_hsa047401.72999653
25Dorso-ventral axis formation_Homo sapiens_hsa043201.70557811
26Arginine biosynthesis_Homo sapiens_hsa002201.63637907
27p53 signaling pathway_Homo sapiens_hsa041151.41537368
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.39985871
29Epstein-Barr virus infection_Homo sapiens_hsa051691.32639115
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.32227966
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29737500
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29508036
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28134677
34Thyroid cancer_Homo sapiens_hsa052161.26364830
35Purine metabolism_Homo sapiens_hsa002301.26351296
36Lysine degradation_Homo sapiens_hsa003101.25112422
37Phenylalanine metabolism_Homo sapiens_hsa003601.17794711
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17158549
39* Herpes simplex infection_Homo sapiens_hsa051681.10837076
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06276459
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98639212
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98392741
43Propanoate metabolism_Homo sapiens_hsa006400.97897509
44HTLV-I infection_Homo sapiens_hsa051660.91358421
45Sulfur relay system_Homo sapiens_hsa041220.87169717
46N-Glycan biosynthesis_Homo sapiens_hsa005100.83601775
47Tyrosine metabolism_Homo sapiens_hsa003500.83429620
48Huntingtons disease_Homo sapiens_hsa050160.80999185
49TGF-beta signaling pathway_Homo sapiens_hsa043500.80716713
50Pentose phosphate pathway_Homo sapiens_hsa000300.80657233
51Arginine and proline metabolism_Homo sapiens_hsa003300.78644383
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73198666
53Butanoate metabolism_Homo sapiens_hsa006500.68198483
54Collecting duct acid secretion_Homo sapiens_hsa049660.65688981
55Viral carcinogenesis_Homo sapiens_hsa052030.64311196
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63271936
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63034074
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59531049
59Retinol metabolism_Homo sapiens_hsa008300.58470885
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.55871151
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54738320
62MicroRNAs in cancer_Homo sapiens_hsa052060.51979878
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51629482
64Galactose metabolism_Homo sapiens_hsa000520.48249958
65Protein export_Homo sapiens_hsa030600.47269901
66Notch signaling pathway_Homo sapiens_hsa043300.46905832
67Small cell lung cancer_Homo sapiens_hsa052220.45945696
68FoxO signaling pathway_Homo sapiens_hsa040680.45752203
69Glycerolipid metabolism_Homo sapiens_hsa005610.45569596
70ABC transporters_Homo sapiens_hsa020100.45208090
71Nicotine addiction_Homo sapiens_hsa050330.43632930
72Type II diabetes mellitus_Homo sapiens_hsa049300.41587143
73* Influenza A_Homo sapiens_hsa051640.40018465
74Synaptic vesicle cycle_Homo sapiens_hsa047210.38996213
75Other glycan degradation_Homo sapiens_hsa005110.38522011
76Biosynthesis of amino acids_Homo sapiens_hsa012300.37546378
77Glutathione metabolism_Homo sapiens_hsa004800.37191884
78Ribosome_Homo sapiens_hsa030100.36937293
79Hippo signaling pathway_Homo sapiens_hsa043900.36093567
80Taste transduction_Homo sapiens_hsa047420.35565726
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34874309
82Vitamin B6 metabolism_Homo sapiens_hsa007500.34067120
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32949461
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32679134
85Tight junction_Homo sapiens_hsa045300.32600042
86Adherens junction_Homo sapiens_hsa045200.31717244
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31521920
88Sphingolipid metabolism_Homo sapiens_hsa006000.31479004
89Regulation of autophagy_Homo sapiens_hsa041400.31131867
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.30502519
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29986812
92Hedgehog signaling pathway_Homo sapiens_hsa043400.29176435
93Insulin signaling pathway_Homo sapiens_hsa049100.27300185
94Alcoholism_Homo sapiens_hsa050340.26173671
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25941977
96Steroid biosynthesis_Homo sapiens_hsa001000.25460103
97Starch and sucrose metabolism_Homo sapiens_hsa005000.25393150
98Choline metabolism in cancer_Homo sapiens_hsa052310.24795696
99Colorectal cancer_Homo sapiens_hsa052100.24077973
100ErbB signaling pathway_Homo sapiens_hsa040120.23715008
101Pathways in cancer_Homo sapiens_hsa052000.23697842
102Pancreatic cancer_Homo sapiens_hsa052120.22426416
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22320347
104Fructose and mannose metabolism_Homo sapiens_hsa000510.20848870
105Fatty acid degradation_Homo sapiens_hsa000710.20385463
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20142284
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19552903
108Nitrogen metabolism_Homo sapiens_hsa009100.19088715
109Antigen processing and presentation_Homo sapiens_hsa046120.18639322
110Circadian rhythm_Homo sapiens_hsa047100.17859734
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17750042
112AMPK signaling pathway_Homo sapiens_hsa041520.16309575
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16151938
114Gap junction_Homo sapiens_hsa045400.15768684
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14411823
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11746550
117Renal cell carcinoma_Homo sapiens_hsa052110.10851260
118Parkinsons disease_Homo sapiens_hsa050120.09902302
119ECM-receptor interaction_Homo sapiens_hsa045120.07543982
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05881987
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.05721314
122Prostate cancer_Homo sapiens_hsa052150.04787027
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.04704959
124Fatty acid elongation_Homo sapiens_hsa000620.04286776
125HIF-1 signaling pathway_Homo sapiens_hsa040660.02305223
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.02211375
127Non-small cell lung cancer_Homo sapiens_hsa052230.02091679
128Systemic lupus erythematosus_Homo sapiens_hsa053220.00141967
129Hepatitis B_Homo sapiens_hsa05161-0.0839850
130Proteoglycans in cancer_Homo sapiens_hsa05205-0.0791558
131Metabolic pathways_Homo sapiens_hsa01100-0.0749050
132mTOR signaling pathway_Homo sapiens_hsa04150-0.0723274
133Long-term potentiation_Homo sapiens_hsa04720-0.0710797
134Ether lipid metabolism_Homo sapiens_hsa00565-0.0706230
135Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0704120
136Glucagon signaling pathway_Homo sapiens_hsa04922-0.0695552
137Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0686607
138Linoleic acid metabolism_Homo sapiens_hsa00591-0.0669808
139Glioma_Homo sapiens_hsa05214-0.0662616
140Apoptosis_Homo sapiens_hsa04210-0.0621719
141Pyruvate metabolism_Homo sapiens_hsa00620-0.0589072
142Toxoplasmosis_Homo sapiens_hsa05145-0.0523266
143Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0415686
144Steroid hormone biosynthesis_Homo sapiens_hsa00140-0.0258437
145Carbon metabolism_Homo sapiens_hsa01200-0.0253117
146Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0248856
147Salmonella infection_Homo sapiens_hsa05132-0.0226702
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142-0.0168365
149Fatty acid metabolism_Homo sapiens_hsa01212-0.0151760
150Wnt signaling pathway_Homo sapiens_hsa04310-0.0151401
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630-0.0031916

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