NXF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.92934931
2synaptonemal complex assembly (GO:0007130)9.54984504
3synaptonemal complex organization (GO:0070193)9.33920135
4fusion of sperm to egg plasma membrane (GO:0007342)9.16925736
5male meiosis (GO:0007140)8.97996244
6DNA methylation involved in gamete generation (GO:0043046)8.86002573
7positive regulation of male gonad development (GO:2000020)7.24141461
8neutrophil activation involved in immune response (GO:0002283)6.89438358
9male meiosis I (GO:0007141)6.83820874
10plasma membrane fusion (GO:0045026)6.81895359
11sex determination (GO:0007530)6.61204630
12sex differentiation (GO:0007548)6.58259925
13chromosome organization involved in meiosis (GO:0070192)6.48363089
14meiotic nuclear division (GO:0007126)6.37077830
15regulation of male gonad development (GO:2000018)6.13409514
16gene silencing by RNA (GO:0031047)5.54867853
17meiosis I (GO:0007127)5.54605576
18cilium or flagellum-dependent cell motility (GO:0001539)5.44784995
19nuclear pore complex assembly (GO:0051292)5.23774786
20spermatid development (GO:0007286)5.11530254
21negative regulation of meiosis (GO:0045835)5.06264179
22male sex determination (GO:0030238)4.92224892
23response to peptidoglycan (GO:0032494)4.88773938
24nuclear pore organization (GO:0006999)4.82663248
25oocyte development (GO:0048599)4.69091307
26positive regulation of meiosis (GO:0045836)4.57836929
27macroautophagy (GO:0016236)4.50664205
28seminiferous tubule development (GO:0072520)4.46082923
29DNA methylation (GO:0006306)4.44792803
30DNA alkylation (GO:0006305)4.44792803
31meiotic cell cycle process (GO:1903046)4.44031776
32negative regulation of erythrocyte differentiation (GO:0045647)4.37357800
33germ cell development (GO:0007281)4.35458226
34thrombin receptor signaling pathway (GO:0070493)4.33115428
35regulation of vitamin D biosynthetic process (GO:0060556)4.26747290
36positive regulation of meiotic cell cycle (GO:0051446)4.21909375
37regulation of gonadotropin secretion (GO:0032276)4.13936722
38response to misfolded protein (GO:0051788)4.13907660
39regulation of protein polyubiquitination (GO:1902914)4.13239721
40regulation of mast cell degranulation (GO:0043304)4.13125137
41oogenesis (GO:0048477)4.10778811
42cellular process involved in reproduction in multicellular organism (GO:0022412)4.09181055
43meiotic cell cycle (GO:0051321)4.07123268
44gene silencing (GO:0016458)4.05820376
45anatomical structure regression (GO:0060033)4.04841936
46granulocyte activation (GO:0036230)3.98789682
47neutrophil activation (GO:0042119)3.97347588
48mannose metabolic process (GO:0006013)3.97035592
49glomerular basement membrane development (GO:0032836)3.95153414
50astrocyte development (GO:0014002)3.94084908
51adenosine receptor signaling pathway (GO:0001973)3.93423389
52cellular response to thyroid hormone stimulus (GO:0097067)3.92762685
53regulation of platelet activation (GO:0010543)3.91307985
54histone H4-K8 acetylation (GO:0043982)3.88049024
55histone H4-K5 acetylation (GO:0043981)3.88049024
56heterochromatin organization (GO:0070828)3.87318985
57sperm motility (GO:0030317)3.86765267
58regulation of histone H3-K9 methylation (GO:0051570)3.84360403
59pore complex assembly (GO:0046931)3.81463626
60regulation of mast cell activation involved in immune response (GO:0033006)3.81242357
61histone H4-K12 acetylation (GO:0043983)3.74201856
62axonemal dynein complex assembly (GO:0070286)3.71150829
63regulation of platelet aggregation (GO:0090330)3.71052838
64negative regulation of DNA repair (GO:0045738)3.70904596
65cellular extravasation (GO:0045123)3.70177718
66G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.69972530
67spermatogenesis (GO:0007283)3.69352652
68male gamete generation (GO:0048232)3.68818573
69positive regulation of mast cell activation (GO:0033005)3.67015160
70glycosphingolipid catabolic process (GO:0046479)3.65872202
71regulation of integrin activation (GO:0033623)3.64801414
72binding of sperm to zona pellucida (GO:0007339)3.64241989
73gonadal mesoderm development (GO:0007506)3.64195703
74mitotic chromosome condensation (GO:0007076)3.64180559
75positive regulation of B cell differentiation (GO:0045579)3.64097432
76acrosome assembly (GO:0001675)3.60716730
77sperm-egg recognition (GO:0035036)3.60538655
78response to thyroid hormone (GO:0097066)3.58754600
79female gamete generation (GO:0007292)3.58210085
80regulation of leukocyte degranulation (GO:0043300)3.57861874
81regulation of myeloid leukocyte mediated immunity (GO:0002886)3.52618906
82Arp2/3 complex-mediated actin nucleation (GO:0034314)3.50173801
83regulation of vitamin metabolic process (GO:0030656)3.46858210
84positive regulation of mast cell degranulation (GO:0043306)3.46604926
85positive regulation of mast cell activation involved in immune response (GO:0033008)3.46604926
86germinal center formation (GO:0002467)3.46521751
87reciprocal meiotic recombination (GO:0007131)3.45037548
88reciprocal DNA recombination (GO:0035825)3.45037548
89chaperone-mediated protein complex assembly (GO:0051131)3.43414037
90gamete generation (GO:0007276)3.40051807
91lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39464495
92DNA methylation or demethylation (GO:0044728)3.38474190
93leukocyte degranulation (GO:0043299)3.37841803
94genitalia morphogenesis (GO:0035112)3.37521510
95positive regulation of gamma-delta T cell activation (GO:0046645)3.37306759
96G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.35337089
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.34610034
98modulation of growth of symbiont involved in interaction with host (GO:0044144)3.34103035
99regulation of growth of symbiont in host (GO:0044126)3.34103035
100negative regulation of growth of symbiont in host (GO:0044130)3.34103035
101negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.34103035
102negative regulation of interleukin-12 production (GO:0032695)3.32661268
103regulation of mast cell activation (GO:0033003)3.31727640
104sister chromatid cohesion (GO:0007062)3.31673643
105myeloid cell activation involved in immune response (GO:0002275)3.31204772
106DNA replication-dependent nucleosome assembly (GO:0006335)3.30153260
107DNA replication-dependent nucleosome organization (GO:0034723)3.30153260
108meiotic chromosome segregation (GO:0045132)3.29718427
109lipoxygenase pathway (GO:0019372)3.29058763
110glycolipid catabolic process (GO:0019377)3.25809367
111positive regulation of macrophage differentiation (GO:0045651)3.23914720
112translesion synthesis (GO:0019985)3.23787024
113pinocytosis (GO:0006907)3.22837104
114epithelial cilium movement (GO:0003351)3.17788794
115regulation of nucleobase-containing compound transport (GO:0032239)3.16944024
116regulation of meiosis (GO:0040020)3.15744052
117motile cilium assembly (GO:0044458)3.13697335
118cell-cell recognition (GO:0009988)3.13671955
119synapsis (GO:0007129)3.12799964
120regulation of hypersensitivity (GO:0002883)3.11449014
121chromatin assembly (GO:0031497)3.11244331
122peptidyl-lysine dimethylation (GO:0018027)3.11137960
123regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10584047
124glial cell proliferation (GO:0014009)3.08174123
125peptide catabolic process (GO:0043171)3.07073891
126regulation of microtubule-based movement (GO:0060632)3.07000672
127negative regulation of microtubule depolymerization (GO:0007026)3.05838405
128megakaryocyte development (GO:0035855)3.03049638
129resolution of meiotic recombination intermediates (GO:0000712)3.02187660
130negative regulation of platelet activation (GO:0010544)3.00947492
131negative regulation of organelle assembly (GO:1902116)3.00888208
132histone H3-K9 methylation (GO:0051567)3.00861645
133negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.00461791
134sphingosine metabolic process (GO:0006670)3.00166976
135purinergic nucleotide receptor signaling pathway (GO:0035590)3.00160419
136platelet aggregation (GO:0070527)2.99878397
137mitotic sister chromatid cohesion (GO:0007064)2.99373031
138DNA packaging (GO:0006323)2.99083303
139regulation of T-helper 1 cell differentiation (GO:0045625)2.98428727
140histone H4-K16 acetylation (GO:0043984)2.98270204
141Leydig cell differentiation (GO:0033327)2.98074375
142fertilization (GO:0009566)2.97925493
143regulation of centriole replication (GO:0046599)2.97788625
144histone H3-K9 demethylation (GO:0033169)2.97696080
145regulation of RNA export from nucleus (GO:0046831)2.96831467
146purinergic receptor signaling pathway (GO:0035587)2.94523153
147positive regulation of leukocyte degranulation (GO:0043302)2.93595151
148mitotic G1 DNA damage checkpoint (GO:0031571)2.89992800
149low-density lipoprotein particle remodeling (GO:0034374)2.87803050
150response to muramyl dipeptide (GO:0032495)2.87536828
151macrophage differentiation (GO:0030225)2.87197140
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85913948
153histone H2A acetylation (GO:0043968)2.83377688
154positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.82672301
155negative regulation of interleukin-17 production (GO:0032700)2.80649532
156triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.80289732
157mature B cell differentiation involved in immune response (GO:0002313)2.79113384
158acrosome reaction (GO:0007340)2.78335954
159diol metabolic process (GO:0034311)2.78290636
160chromosome condensation (GO:0030261)2.78266704
161regulation of microtubule depolymerization (GO:0031114)2.78127570
162regulation of MHC class II biosynthetic process (GO:0045346)2.78023819
163negative regulation of homotypic cell-cell adhesion (GO:0034111)2.76514914
164ceramide catabolic process (GO:0046514)2.76286763
165negative regulation of monooxygenase activity (GO:0032769)2.75901338
166protein neddylation (GO:0045116)2.75586777
167positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.75477090
168positive regulation of tumor necrosis factor production (GO:0032760)2.75427011
169positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.75246550
170negative regulation of interleukin-8 production (GO:0032717)2.74403534
171neutrophil mediated immunity (GO:0002446)2.71778667
172oligosaccharide catabolic process (GO:0009313)2.71122724
173immunoglobulin mediated immune response (GO:0016064)2.71031141
174regulation of homotypic cell-cell adhesion (GO:0034110)2.70756100
175actin nucleation (GO:0045010)2.70375811
176regulation of regulated secretory pathway (GO:1903305)2.69111280
177negative regulation of interleukin-6 production (GO:0032715)2.64911073
178monocyte chemotaxis (GO:0002548)2.59072113
179positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57841529
180negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.57596280
181positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57208235
182negative regulation of cytokine production involved in immune response (GO:0002719)2.52773597
183positive regulation of cellular amide metabolic process (GO:0034250)2.52629926
184actin filament polymerization (GO:0030041)2.52058691
185response to protozoan (GO:0001562)2.51539920
186polyamine biosynthetic process (GO:0006596)2.49761997
187leukocyte migration involved in inflammatory response (GO:0002523)2.49476827
188leukocyte mediated cytotoxicity (GO:0001909)2.49395151
189regulation of interleukin-6 production (GO:0032675)2.49230724
190positive regulation of systemic arterial blood pressure (GO:0003084)2.47256975
191regulation of erythrocyte differentiation (GO:0045646)2.46852805
192cellular response to arsenic-containing substance (GO:0071243)2.46282382
193regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.45355111
194positive regulation of toll-like receptor signaling pathway (GO:0034123)2.45157384
195regulation of mononuclear cell migration (GO:0071675)2.44963836
196regulation of tumor necrosis factor production (GO:0032680)2.44681830
197positive regulation of bone resorption (GO:0045780)2.43503720
198positive regulation of bone remodeling (GO:0046852)2.43503720
199piRNA metabolic process (GO:0034587)12.5319852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.75367463
2STAT6_21828071_ChIP-Seq_BEAS2B_Human6.30833393
3E2F7_22180533_ChIP-Seq_HELA_Human4.78787738
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.08154320
5VDR_21846776_ChIP-Seq_THP-1_Human4.07442270
6SCL_19346495_ChIP-Seq_HPC-7_Human3.97048275
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.84444140
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.84444140
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.84444140
10VDR_24763502_ChIP-Seq_THP-1_Human3.68170120
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.60702283
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.58217860
13IRF8_21731497_ChIP-ChIP_J774_Mouse3.44812592
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.19654193
15IRF8_22096565_ChIP-ChIP_GC-B_Human3.18407489
16MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07913452
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.94845207
18SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.94466632
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82180257
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.71620233
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70204389
22SPI1_23127762_ChIP-Seq_K562_Human2.68552215
23ZNF263_19887448_ChIP-Seq_K562_Human2.66620058
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.63659041
25GATA1_22025678_ChIP-Seq_K562_Human2.57440061
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50977055
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.46221276
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.43336505
29GATA1_19941826_ChIP-Seq_K562_Human2.41944809
30SPI1_23547873_ChIP-Seq_NB4_Human2.41814020
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40740648
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27705322
33MYC_22102868_ChIP-Seq_BL_Human2.24526911
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.21954020
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20115850
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19828716
37RUNX1_22412390_ChIP-Seq_EML_Mouse2.17768809
38GATA1_19941827_ChIP-Seq_MEL_Mouse2.14765955
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13694097
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11818624
41BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07668966
42VDR_24787735_ChIP-Seq_THP-1_Human2.07355234
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06136549
44GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.96226361
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.96116790
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94579464
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.93650921
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89150110
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.88001151
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87359100
51LXR_22292898_ChIP-Seq_THP-1_Human1.87236122
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.87185762
53* GATA2_19941826_ChIP-Seq_K562_Human1.86838332
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.84748249
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82724518
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80507351
57UTX_26944678_Chip-Seq_JUKART_Human1.79157034
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76033556
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67806606
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.66314236
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63186554
62MYB_26560356_Chip-Seq_TH2_Human1.62023666
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59773897
64AR_21909140_ChIP-Seq_LNCAP_Human1.59190733
65RNF2_27304074_Chip-Seq_NSC_Mouse1.56760137
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56661102
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.55087491
68MAF_26560356_Chip-Seq_TH1_Human1.54180674
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53952751
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45504346
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43745051
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43515833
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43498696
74MYB_26560356_Chip-Seq_TH1_Human1.43184399
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41760103
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41509845
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41230796
78TCF7_22412390_ChIP-Seq_EML_Mouse1.39814774
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39363464
80SPI1_20517297_ChIP-Seq_HL60_Human1.37876653
81STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37749917
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.34454522
83STAT1_20625510_ChIP-Seq_HELA_Human1.33692749
84TP53_22127205_ChIP-Seq_IMR90_Human1.32755417
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32057129
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31030378
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30715344
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29998278
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28372014
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27980416
91BCOR_27268052_Chip-Seq_Bcells_Human1.27634484
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26668614
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26214615
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25840739
95KDM2B_26808549_Chip-Seq_DND41_Human1.21593258
96BCL6_27268052_Chip-Seq_Bcells_Human1.20190472
97MAF_26560356_Chip-Seq_TH2_Human1.19870657
98POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19030288
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.18965616
100FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17297944
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16911419
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16769683
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16081693
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16019046
105* OCT4_19829295_ChIP-Seq_ESCs_Human1.15900844
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.15858849
107RUNX_20019798_ChIP-Seq_JUKART_Human1.15677564
108MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14942084
109* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14798852
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13868997
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13835230
112KDM5A_27292631_Chip-Seq_BREAST_Human1.13352045
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12368587
114NCOR1_26117541_ChIP-Seq_K562_Human1.12184717
115ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11271078
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09564992
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09289998
118CLOCK_20551151_ChIP-Seq_293T_Human1.09087223
119PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08348211
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08305508
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07986898
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07663610
123CHD1_26751641_Chip-Seq_LNCaP_Human1.07267844
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06313576
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05610332
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05437044
127NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04712544
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04531135
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04415863
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04307390
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03940128
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03874722
133PU_27001747_Chip-Seq_BMDM_Mouse1.01995757
134E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01881728
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01798549
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01136502
137CREB1_26743006_Chip-Seq_LNCaP_Human1.00054550
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99335537
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98252036
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96781756
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96127908
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95953767
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95813805
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95615700
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95380488
146ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95203634
147TFEB_21752829_ChIP-Seq_HELA_Human0.95137279
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94604005
149P300_27268052_Chip-Seq_Bcells_Human0.94336206
150FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93848870
151SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93813452
152* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91933739
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91264911
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.90119603
155EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90024449
156MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89082950
157KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88172062
158KDM2B_26808549_Chip-Seq_K562_Human0.87910445
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87818374
160CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87738290
161TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87666333
162ETS1_21867929_ChIP-Seq_TH2_Mouse0.86472700
163ELF1_20517297_ChIP-Seq_JURKAT_Human0.85694102
164EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85134927
165RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84881281
166ESR1_21235772_ChIP-Seq_MCF-7_Human0.83581254
167SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82737268
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82607918
169PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.82543329
170MYC_18555785_ChIP-Seq_MESCs_Mouse0.80634101
171SMC4_20622854_ChIP-Seq_HELA_Human0.79936782
172FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79284271
173TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77953926
174WDR5_24793694_ChIP-Seq_LNCAP_Human0.77421821
175HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77254810
176RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76687669
177SOX2_18692474_ChIP-Seq_MESCs_Mouse0.76553591
178CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76546597
179KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75471377
180WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75001291
181TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.74321294
182TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73276815
183GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.72418402
184TET1_21490601_ChIP-Seq_MESCs_Mouse0.72175801
185SOX11_22085726_ChIP-Seq_ESNs_Mouse0.71956879
186CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71832490
187KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71696503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.09571750
2MP0008995_early_reproductive_senescence6.50772477
3MP0003878_abnormal_ear_physiology5.65786033
4MP0005377_hearing/vestibular/ear_phenot5.65786033
5MP0005464_abnormal_platelet_physiology5.07255335
6MP0005410_abnormal_fertilization4.86949890
7MP0005058_abnormal_lysosome_morphology4.47510772
8MP0003303_peritoneal_inflammation4.42207223
9MP0008004_abnormal_stomach_pH4.26329105
10MP0002210_abnormal_sex_determination3.38018915
11MP0001929_abnormal_gametogenesis3.35434442
12MP0003786_premature_aging3.30586695
13MP0003698_abnormal_male_reproductive3.10144302
14MP0001145_abnormal_male_reproductive2.94235592
15MP0003436_decreased_susceptibility_to2.85133001
16MP0001835_abnormal_antigen_presentation2.81770692
17MP0003172_abnormal_lysosome_physiology2.62066491
18MP0003724_increased_susceptibility_to2.59562557
19MP0002148_abnormal_hypersensitivity_rea2.52873311
20MP0000653_abnormal_sex_gland2.47484063
21MP0002419_abnormal_innate_immunity2.46779890
22MP0001545_abnormal_hematopoietic_system2.44623816
23MP0005397_hematopoietic_system_phenotyp2.44623816
24MP0000343_altered_response_to2.35297693
25MP0008057_abnormal_DNA_replication2.34950665
26MP0001727_abnormal_embryo_implantation2.18083856
27MP0005025_abnormal_response_to2.17752273
28MP0005000_abnormal_immune_tolerance2.10817787
29MP0006082_CNS_inflammation2.07729169
30MP0000465_gastrointestinal_hemorrhage2.07572010
31MP0003195_calcinosis2.03956124
32MP0005647_abnormal_sex_gland2.03756437
33MP0003879_abnormal_hair_cell2.01878603
34MP0009840_abnormal_foam_cell2.00556747
35MP0001661_extended_life_span1.98225940
36MP0009785_altered_susceptibility_to1.93609542
37MP0010155_abnormal_intestine_physiology1.88039085
38MP0005671_abnormal_response_to1.86314301
39MP0003656_abnormal_erythrocyte_physiolo1.84287725
40MP0009764_decreased_sensitivity_to1.81420385
41MP0002452_abnormal_antigen_presenting1.79778290
42MP0003045_fibrosis1.78074262
43MP0002723_abnormal_immune_serum1.77257818
44MP0004510_myositis1.76153714
45MP0004947_skin_inflammation1.72079054
46MP0002161_abnormal_fertility/fecundity1.71963599
47MP0005387_immune_system_phenotype1.70490517
48MP0001790_abnormal_immune_system1.70490517
49MP0010094_abnormal_chromosome_stability1.65046124
50MP0003123_paternal_imprinting1.64056911
51MP0002420_abnormal_adaptive_immunity1.63909029
52MP0002160_abnormal_reproductive_system1.63449826
53MP0001819_abnormal_immune_cell1.61473169
54MP0001800_abnormal_humoral_immune1.61423581
55MP0001845_abnormal_inflammatory_respons1.59883719
56MP0002102_abnormal_ear_morphology1.56922580
57MP0001533_abnormal_skeleton_physiology1.56481471
58MP0005451_abnormal_body_composition1.56456083
59MP0000569_abnormal_digit_pigmentation1.56034229
60MP0002653_abnormal_ependyma_morphology1.54815515
61MP0003828_pulmonary_edema1.53620706
62MP0004742_abnormal_vestibular_system1.53090758
63MP0003315_abnormal_perineum_morphology1.50174579
64MP0005623_abnormal_meninges_morphology1.49930389
65MP0000685_abnormal_immune_system1.49002510
66MP0002398_abnormal_bone_marrow1.48863679
67MP0005076_abnormal_cell_differentiation1.48751718
68MP0003075_altered_response_to1.44373081
69MP0002139_abnormal_hepatobiliary_system1.42162172
70MP0002405_respiratory_system_inflammati1.35434069
71MP0000716_abnormal_immune_system1.33200891
72MP0002877_abnormal_melanocyte_morpholog1.31774152
73MP0001853_heart_inflammation1.29488723
74MP0003787_abnormal_imprinting1.29164104
75MP0000689_abnormal_spleen_morphology1.28155671
76MP0003936_abnormal_reproductive_system1.27534877
77MP0002722_abnormal_immune_system1.27483157
78MP0000858_altered_metastatic_potential1.26208514
79MP0003111_abnormal_nucleus_morphology1.25942256
80MP0002998_abnormal_bone_remodeling1.25935318
81MP0004084_abnormal_cardiac_muscle1.25705164
82MP0002429_abnormal_blood_cell1.25330805
83MP0008469_abnormal_protein_level1.22794267
84MP0010307_abnormal_tumor_latency1.21964971
85MP0003077_abnormal_cell_cycle1.18693279
86MP0004885_abnormal_endolymph1.17741329
87MP0009333_abnormal_splenocyte_physiolog1.16302107
88MP0004197_abnormal_fetal_growth/weight/1.14597932
89MP0004957_abnormal_blastocyst_morpholog1.13808769
90MP0009278_abnormal_bone_marrow1.12465654
91MP0005389_reproductive_system_phenotype1.10887400
92MP0001440_abnormal_grooming_behavior1.10364981
93MP0000015_abnormal_ear_pigmentation1.09086899
94MP0000490_abnormal_crypts_of1.08736485
95MP0005666_abnormal_adipose_tissue1.07638474
96MP0001730_embryonic_growth_arrest1.06557538
97MP0008058_abnormal_DNA_repair1.06506285
98MP0009763_increased_sensitivity_to1.06185572
99MP0000751_myopathy1.05372060
100MP0002168_other_aberrant_phenotype1.05269085
101MP0000427_abnormal_hair_cycle1.04475507
102MP0002396_abnormal_hematopoietic_system1.04169997
103MP0004272_abnormal_basement_membrane1.02948976
104MP0003453_abnormal_keratinocyte_physiol1.01737039
105MP0002837_dystrophic_cardiac_calcinosis1.01057759
106MP0001663_abnormal_digestive_system1.00873829
107MP0001119_abnormal_female_reproductive1.00252109
108MP0003763_abnormal_thymus_physiology0.98315817
109MP0002132_abnormal_respiratory_system0.98274430
110MP0000537_abnormal_urethra_morphology0.95470776
111MP0003121_genomic_imprinting0.94974568
112MP0005165_increased_susceptibility_to0.94335208
113MP0003191_abnormal_cellular_cholesterol0.92502387
114MP0002084_abnormal_developmental_patter0.91646799
115MP0005166_decreased_susceptibility_to0.91384437
116MP0001851_eye_inflammation0.89530721
117MP0000604_amyloidosis0.89454562
118MP0003705_abnormal_hypodermis_morpholog0.88635668
119MP0008007_abnormal_cellular_replicative0.86238926
120MP0003115_abnormal_respiratory_system0.85319050
121MP0000249_abnormal_blood_vessel0.84461246
122MP0004185_abnormal_adipocyte_glucose0.83377020
123MP0006138_congestive_heart_failure0.82838049
124MP0003942_abnormal_urinary_system0.82706312
125MP0003448_altered_tumor_morphology0.82209633
126MP0003699_abnormal_female_reproductive0.80400394
127MP0003638_abnormal_response/metabolism_0.79858461
128MP0005174_abnormal_tail_pigmentation0.79816412
129MP0004381_abnormal_hair_follicle0.79279408
130MP0000639_abnormal_adrenal_gland0.79029265
131MP0003806_abnormal_nucleotide_metabolis0.78359521
132MP0005164_abnormal_response_to0.77175079
133MP0005360_urolithiasis0.75842257
134MP0000703_abnormal_thymus_morphology0.75096194
135MP0009765_abnormal_xenobiotic_induced0.74908944
136MP0005167_abnormal_blood-brain_barrier0.74735242
137MP0004130_abnormal_muscle_cell0.74503222
138MP0006054_spinal_hemorrhage0.73892624
139MP0003890_abnormal_embryonic-extraembry0.73889017
140MP0008260_abnormal_autophagy0.73560010
141MP0003283_abnormal_digestive_organ0.72640973
142MP0005083_abnormal_biliary_tract0.72302263
143MP0003866_abnormal_defecation0.72279365
144MP0002085_abnormal_embryonic_tissue0.71697373
145MP0004036_abnormal_muscle_relaxation0.71370042
146MP0003119_abnormal_digestive_system0.70702415
147MP0002086_abnormal_extraembryonic_tissu0.69741875
148MP0003183_abnormal_peptide_metabolism0.69727448
149MP0005380_embryogenesis_phenotype0.69132057
150MP0001672_abnormal_embryogenesis/_devel0.69132057
151MP0005365_abnormal_bile_salt0.66822683
152MP0000350_abnormal_cell_proliferation0.65812763
153MP0005535_abnormal_body_temperature0.65393500
154MP0008874_decreased_physiological_sensi0.65041405
155MP0003795_abnormal_bone_structure0.64453664
156MP0004233_abnormal_muscle_weight0.64260201
157MP0001697_abnormal_embryo_size0.63721215
158MP0005670_abnormal_white_adipose0.63500492
159MP0008961_abnormal_basal_metabolism0.62417296
160MP0005395_other_phenotype0.62406124
161MP0006036_abnormal_mitochondrial_physio0.61679690
162MP0004883_abnormal_blood_vessel0.61150239
163MP0003984_embryonic_growth_retardation0.60794292
164MP0001919_abnormal_reproductive_system0.60450465
165MP0003693_abnormal_embryo_hatching0.60156399
166MP0008932_abnormal_embryonic_tissue0.60041401
167MP0002088_abnormal_embryonic_growth/wei0.58535871
168MP0005248_abnormal_Harderian_gland0.56761302
169MP0010352_gastrointestinal_tract_polyps0.55757737
170MP0001485_abnormal_pinna_reflex0.55531878
171MP0002080_prenatal_lethality0.55437723
172MP0004808_abnormal_hematopoietic_stem0.54982819
173MP0009703_decreased_birth_body0.54118958
174MP0002009_preneoplasia0.53762754
175MP0004043_abnormal_pH_regulation0.49479663
176MP0003300_gastrointestinal_ulcer0.47239709
177MP0000313_abnormal_cell_death0.46570820
178MP0005310_abnormal_salivary_gland0.45811687
179MP0009672_abnormal_birth_weight0.44341682
180MP0003091_abnormal_cell_migration0.44120244
181MP0002092_abnormal_eye_morphology0.43447549
182MP0003567_abnormal_fetal_cardiomyocyte0.40880676
183MP0001293_anophthalmia0.38950405
184MP0004147_increased_porphyrin_level0.38684635
185MP0000631_abnormal_neuroendocrine_gland0.37674226
186MP0003632_abnormal_nervous_system0.37492225
187MP0003566_abnormal_cell_adhesion0.37120374
188MP0005391_vision/eye_phenotype0.36898821

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.99183141
2Gonadotropin excess (HP:0000837)7.27756908
3Petechiae (HP:0000967)6.65474071
4Prolonged bleeding time (HP:0003010)6.31052243
5Gonadal dysgenesis (HP:0000133)6.10312229
611 pairs of ribs (HP:0000878)6.03345360
7Azoospermia (HP:0000027)5.83683308
8Purpura (HP:0000979)5.76065867
9Hand muscle atrophy (HP:0009130)5.25705571
10Abnormal spermatogenesis (HP:0008669)5.04720839
11Epistaxis (HP:0000421)4.91865286
12Abnormality of the lower motor neuron (HP:0002366)4.88432259
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77653345
14Increased cerebral lipofuscin (HP:0011813)4.67390230
15Infertility (HP:0000789)4.64605011
16Menorrhagia (HP:0000132)4.58925052
17Absent/shortened dynein arms (HP:0200106)4.57423560
18Dynein arm defect of respiratory motile cilia (HP:0012255)4.57423560
19Increased neuronal autofluorescent lipopigment (HP:0002074)4.51644827
20Vacuolated lymphocytes (HP:0001922)4.50182683
21Abnormal platelet volume (HP:0011876)4.49655956
22Increased mean platelet volume (HP:0011877)4.47103113
23Metaphyseal cupping (HP:0003021)4.31634951
24Abnormality of glycolipid metabolism (HP:0010969)4.27534231
25Abnormality of liposaccharide metabolism (HP:0010968)4.27534231
26Abnormality of glycosphingolipid metabolism (HP:0004343)4.27534231
27Dysostosis multiplex (HP:0000943)4.23393561
28Recurrent abscess formation (HP:0002722)4.16752745
29Distal upper limb amyotrophy (HP:0007149)4.16490486
30Upper limb amyotrophy (HP:0009129)4.16490486
31Facial diplegia (HP:0001349)4.09625721
32Missing ribs (HP:0000921)4.07596821
33Impaired platelet aggregation (HP:0003540)4.05208509
34Abnormal platelet function (HP:0011869)4.05208509
35Male pseudohermaphroditism (HP:0000037)4.04640707
36Tongue fasciculations (HP:0001308)4.03146826
37Abnormality of macrophages (HP:0004311)3.87781352
38Ankle clonus (HP:0011448)3.84947194
39Spontaneous hematomas (HP:0007420)3.84698154
40Gingival bleeding (HP:0000225)3.82348019
41Abnormal sex determination (HP:0012244)3.80024512
42Sex reversal (HP:0012245)3.80024512
43Abnormality of the vasculature of the conjunctiva (HP:0008054)3.76728242
44Testicular neoplasm (HP:0010788)3.68965408
45Muscle fibrillation (HP:0010546)3.65438937
46Diaphragmatic weakness (HP:0009113)3.64801791
47Recurrent bacterial skin infections (HP:0005406)3.64758284
48Stomatitis (HP:0010280)3.46512831
49Stridor (HP:0010307)3.46321869
50Conjunctival telangiectasia (HP:0000524)3.35090648
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.28314169
52Hepatosplenomegaly (HP:0001433)3.26510674
53Abnormality of male internal genitalia (HP:0000022)3.21142003
54Abnormal respiratory motile cilium physiology (HP:0012261)3.17917592
55Paralysis (HP:0003470)3.08699020
56Thrombocytosis (HP:0001894)3.06505409
57Eczematoid dermatitis (HP:0000976)3.04289324
58Loss of speech (HP:0002371)3.04273766
59Abnormality of the musculature of the hand (HP:0001421)3.00922640
60Chronic obstructive pulmonary disease (HP:0006510)2.90412865
61Obstructive lung disease (HP:0006536)2.90412865
62Systemic lupus erythematosus (HP:0002725)2.90231470
63Increased serum ferritin (HP:0003281)2.87496377
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.84738792
65Mesangial abnormality (HP:0001966)2.82833441
66Clumsiness (HP:0002312)2.81751117
67Rhinitis (HP:0012384)2.81336478
68Abnormal respiratory epithelium morphology (HP:0012253)2.80608989
69Abnormal respiratory motile cilium morphology (HP:0005938)2.80608989
70Amyotrophic lateral sclerosis (HP:0007354)2.80163385
71Abnormality of lateral ventricle (HP:0030047)2.78213820
72Thoracic kyphosis (HP:0002942)2.72842559
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.70633470
74Autoimmune thrombocytopenia (HP:0001973)2.69248448
75Clonus (HP:0002169)2.68186447
76Fibular hypoplasia (HP:0003038)2.65069593
77Abnormality of iron homeostasis (HP:0011031)2.64894456
78Poikilocytosis (HP:0004447)2.63709819
79Selective tooth agenesis (HP:0001592)2.55190620
80Hypoventilation (HP:0002791)2.55186332
81Myopathic facies (HP:0002058)2.51999374
82Heterotopia (HP:0002282)2.51083086
83Acanthocytosis (HP:0001927)2.50941123
84Abnormal pupillary function (HP:0007686)2.50117294
85Polycythemia (HP:0001901)2.45186437
86Acute lymphatic leukemia (HP:0006721)2.44310129
87Ependymoma (HP:0002888)2.42130829
88Secondary amenorrhea (HP:0000869)2.41915965
89Hyperlipoproteinemia (HP:0010980)2.40814120
90Abnormality of the vocal cords (HP:0008777)2.39145678
91Stage 5 chronic kidney disease (HP:0003774)2.37248822
92Myocardial infarction (HP:0001658)2.37194934
93Elevated erythrocyte sedimentation rate (HP:0003565)2.35577143
94Nasal polyposis (HP:0100582)2.35498051
95Disinhibition (HP:0000734)2.34983309
96Chronic bronchitis (HP:0004469)2.34035041
97Abnormal ciliary motility (HP:0012262)2.31196041
98Granulocytopenia (HP:0001913)2.29100243
99Renovascular hypertension (HP:0100817)2.27468424
100Dyschromatopsia (HP:0007641)2.25435304
101Recurrent gram-negative bacterial infections (HP:0005420)2.22593220
102Rectal prolapse (HP:0002035)2.22457489
103Recurrent viral infections (HP:0004429)2.21481000
104Nausea (HP:0002018)2.21181750
105Increased density of long bones (HP:0006392)2.20379901
106Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20335698
107Abnormality of polysaccharide metabolism (HP:0011012)2.20335698
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20335698
109Primary amenorrhea (HP:0000786)2.18887686
110Abnormality of transition element cation homeostasis (HP:0011030)2.18371515
111Amyloidosis (HP:0011034)2.18109183
112Astrocytoma (HP:0009592)2.17332730
113Abnormality of the astrocytes (HP:0100707)2.17332730
114Rhizomelia (HP:0008905)2.17137399
115Mucopolysacchariduria (HP:0008155)2.16684925
116Urinary glycosaminoglycan excretion (HP:0003541)2.16684925
117Colitis (HP:0002583)2.14009549
118Hyporeflexia of lower limbs (HP:0002600)2.13595449
119Abnormality of the calcaneus (HP:0008364)2.12880738
120Arterial thrombosis (HP:0004420)2.12391929
121B lymphocytopenia (HP:0010976)2.10959886
122Myositis (HP:0100614)2.10299457
123Abnormality of the lumbar spine (HP:0100712)2.09951259
124Impulsivity (HP:0100710)2.09730040
125Nuclear cataract (HP:0100018)2.09246017
126Inflammation of the large intestine (HP:0002037)2.07824321
127Nephronophthisis (HP:0000090)2.07818494
128Bruising susceptibility (HP:0000978)2.07161839
129Recurrent fungal infections (HP:0002841)2.06723731
130Encephalitis (HP:0002383)2.03028424
131Recurrent skin infections (HP:0001581)2.02941938
132Occipital encephalocele (HP:0002085)2.01919176
133Abnormality of the thoracic spine (HP:0100711)2.01893913
134Abnormality of B cell number (HP:0010975)2.01451767
135Germ cell neoplasia (HP:0100728)2.00646583
136Basal ganglia calcification (HP:0002135)2.00082520
137J-shaped sella turcica (HP:0002680)1.99626930
138Gastrointestinal inflammation (HP:0004386)1.98520955
139Gingivitis (HP:0000230)1.98062744
140Mediastinal lymphadenopathy (HP:0100721)1.97471362
141Fasciculations (HP:0002380)1.96693945
142Autoimmune hemolytic anemia (HP:0001890)1.96690415
143Mucosal telangiectasiae (HP:0100579)1.96647491
144Acute myeloid leukemia (HP:0004808)1.96606378
145Glomerulonephritis (HP:0000099)1.96572893
146Mutism (HP:0002300)1.94801188
147Hemorrhage of the eye (HP:0011885)1.93366264
148Joint swelling (HP:0001386)1.93008854
149Interstitial pulmonary disease (HP:0006530)1.91168408
150Degeneration of anterior horn cells (HP:0002398)1.89987865
151Abnormality of the anterior horn cell (HP:0006802)1.89987865
152Increased IgE level (HP:0003212)1.88235258
153Tinnitus (HP:0000360)1.87775328
154Hyperacusis (HP:0010780)1.87664250
155Abnormality of the prostate (HP:0008775)1.87371339
156Abnormality of the nasal mucosa (HP:0000433)1.86202601
157Hypoplasia of the uterus (HP:0000013)1.85302891
158Tubulointerstitial nephritis (HP:0001970)1.85106842
159Upper motor neuron abnormality (HP:0002127)1.84349840
160Ankle contracture (HP:0006466)1.82686087
161Back pain (HP:0003418)1.82529798
162Axonal loss (HP:0003447)1.82209603
163Polycystic ovaries (HP:0000147)1.79484381
164Neurodegeneration (HP:0002180)1.79332018
165Premature ovarian failure (HP:0008209)1.77876844
166Bladder diverticulum (HP:0000015)1.77782863
167Prominent nose (HP:0000448)1.77553799
168Pustule (HP:0200039)1.75149801
169Hypopigmentation of the fundus (HP:0007894)1.74863912
170Ovarian neoplasm (HP:0100615)1.74711819
171Personality changes (HP:0000751)1.74123362
172Ventricular fibrillation (HP:0001663)1.73962521
173Spondylolisthesis (HP:0003302)1.73508566
174Hematochezia (HP:0002573)1.73177084
175Thin ribs (HP:0000883)1.72966549
176Ectopic kidney (HP:0000086)1.70579299
177Pulmonary fibrosis (HP:0002206)1.70007498
178Hyperpituitarism (HP:0010514)1.69134809
179Nephroblastoma (Wilms tumor) (HP:0002667)1.64968369
180Aplasia/Hypoplasia of the fibula (HP:0006492)1.64575563
181Increased nuchal translucency (HP:0010880)1.63575570
182Tubular atrophy (HP:0000092)1.62369233
183Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59310627
184Chromsome breakage (HP:0040012)1.59131068
185Overriding aorta (HP:0002623)1.58352594
186Bronchiectasis (HP:0002110)1.57481735
187Oligodactyly (HP:0012165)1.57411810
188Glioma (HP:0009733)1.56073427
189Abnormality of dentin (HP:0010299)1.55239607
190Hypoplasia of the iris (HP:0007676)1.54797445
191Bulbar palsy (HP:0001283)1.54733291
192Supernumerary spleens (HP:0009799)1.53934387
193External ophthalmoplegia (HP:0000544)1.53751331
194Difficulty climbing stairs (HP:0003551)1.52964560
195Renal duplication (HP:0000075)1.52526234
196Elfin facies (HP:0004428)1.51619793
197Cerebral aneurysm (HP:0004944)1.51383403
198Chromosomal breakage induced by crosslinking agents (HP:0003221)1.49931818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.48324559
2RIPK45.19464925
3IRAK34.76458384
4PDK34.75991844
5PDK44.75991844
6ICK3.77988061
7TYRO33.57174478
8PRKD32.97494820
9PDK22.86407268
10BLK2.86401372
11NME22.83132288
12BRD42.64015981
13MAP2K32.51889563
14WNK32.40428089
15CDC72.40332598
16BTK2.36843450
17NEK22.25430815
18TEC2.16134517
19WNK42.03628574
20MAP3K142.00089424
21TAOK21.99591095
22ZAP701.97561136
23SYK1.95168347
24PRPF4B1.91578846
25PNCK1.91224301
26MATK1.87332152
27TESK11.82910499
28WNK11.78398694
29MAP3K41.74617380
30CSF1R1.70973141
31PIK3CG1.69551288
32PTK2B1.69464414
33CDK71.69143635
34FES1.66856945
35GRK71.59978047
36CDK91.58526529
37PIM21.58143452
38TRIB31.56572165
39MARK31.55619134
40TBK11.54072114
41LYN1.52690102
42KIT1.50634461
43TAOK31.48884979
44WEE11.43643447
45MAP4K11.42682657
46RIPK11.41130625
47IKBKB1.37249656
48BMPR21.36439428
49FGR1.36214586
50STK31.32324540
51CDK41.25846849
52ATR1.25537447
53MTOR1.24602647
54MAP3K111.19628076
55EEF2K1.16340320
56EPHB11.16200168
57CHEK11.15839400
58FLT31.13172189
59PAK41.13087688
60LATS11.12383730
61TTK1.10110732
62IRAK41.09868959
63HCK1.09781933
64MAP3K31.06416179
65PTK61.06087169
66TGFBR21.05404424
67TESK21.00111390
68STK101.00079498
69TAOK10.96839781
70PDPK10.94642429
71CSK0.92961103
72ATM0.92376952
73CAMKK20.91327862
74PAK20.90785163
75DAPK30.90544554
76MAP3K60.89740434
77GRK60.89223446
78PLK10.87627389
79PKN20.87446387
80CAMK1G0.86331273
81MAPK120.86203683
82STK390.85878031
83PDGFRA0.83609935
84ACVR1B0.83109184
85PINK10.82924516
86JAK20.81919792
87ILK0.81186258
88TYK20.80918726
89CHEK20.80715648
90TLK10.80426154
91MAP3K10.79267250
92LMTK20.74911108
93MAPKAPK30.74795537
94MST40.73607873
95ITK0.73182214
96MAP3K100.72075352
97MAP3K50.71946601
98TXK0.71414286
99PTK20.71074162
100CDK60.70388775
101BMX0.69312498
102MAP3K130.68728490
103MET0.65075019
104LCK0.64502567
105EIF2AK10.63803600
106EPHA20.62875556
107CSNK1A1L0.62282723
108MAPK40.62092272
109CDK20.61523608
110DAPK10.58694744
111RET0.57476052
112PASK0.57447782
113DAPK20.55630276
114MKNK20.54753669
115MOS0.54497543
116CDK10.54285790
117MAP2K60.54238148
118ALK0.54126687
119ADRBK20.53254462
120PRKDC0.53064968
121CDC42BPA0.52195380
122PAK60.51783083
123FGFR10.51424531
124MAP3K80.50943998
125SMG10.50633813
126IKBKE0.49613114
127STK40.46608659
128CAMK1D0.46584947
129PIM10.46114688
130HIPK20.45102015
131NEK10.43943173
132STK38L0.43591462
133RPS6KA50.43580417
134IRAK20.42979133
135MYLK0.42448566
136GSK3B0.41264739
137DYRK1B0.41229060
138SRPK10.41106901
139CSNK1D0.40132544
140MAPK10.40065841
141ABL20.40000537
142AURKB0.38498474
143TNK20.37341703
144MAP2K40.36754010
145PDGFRB0.36679652
146PRKAA20.36517730
147NEK90.35436446
148EGFR0.35320889
149CSNK1E0.34669213
150CLK10.34131629
151DDR20.33181268
152MAPK140.32901839
153PAK10.32715421
154PRKACB0.32600045
155SCYL20.32580684
156PRKCQ0.32395600
157LRRK20.32044929
158MAPK110.31501789
159LATS20.31177152
160MAP2K20.29824334
161KSR20.29625789
162MKNK10.28429965
163MAPK80.27984280
164MAPK150.27491855
165FER0.26078072
166BCR0.25068606
167MAPK100.23894073
168PAK30.23189160
169PDK10.22972228
170TTN0.21357094
171PLK30.21323475
172MELK0.20585585
173ERN10.20493587
174AKT10.19503975
175MAPK30.19416825
176GSK3A0.18652270

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.16827928
2Dorso-ventral axis formation_Homo sapiens_hsa043203.98012427
3Fatty acid biosynthesis_Homo sapiens_hsa000613.57732811
4Platelet activation_Homo sapiens_hsa046112.67890728
5Basal transcription factors_Homo sapiens_hsa030222.47192919
6Lysosome_Homo sapiens_hsa041422.43865271
7* RNA transport_Homo sapiens_hsa030132.41442754
8Osteoclast differentiation_Homo sapiens_hsa043802.39374471
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.38085900
10Vitamin digestion and absorption_Homo sapiens_hsa049772.30548181
11Lysine degradation_Homo sapiens_hsa003102.30458980
12* mRNA surveillance pathway_Homo sapiens_hsa030152.28902511
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22181992
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.21846075
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20164661
16Fatty acid metabolism_Homo sapiens_hsa012122.10551866
17Fanconi anemia pathway_Homo sapiens_hsa034602.07373908
18* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06423000
19Oocyte meiosis_Homo sapiens_hsa041142.04992282
20B cell receptor signaling pathway_Homo sapiens_hsa046622.03756247
21Hematopoietic cell lineage_Homo sapiens_hsa046402.03292873
22Pyruvate metabolism_Homo sapiens_hsa006201.98207400
23Staphylococcus aureus infection_Homo sapiens_hsa051501.97599222
24Leishmaniasis_Homo sapiens_hsa051401.97543628
25Malaria_Homo sapiens_hsa051441.94446366
26Asthma_Homo sapiens_hsa053101.89665622
27Cell cycle_Homo sapiens_hsa041101.81890535
28Selenocompound metabolism_Homo sapiens_hsa004501.80659729
29Small cell lung cancer_Homo sapiens_hsa052221.79959671
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.77287042
31Acute myeloid leukemia_Homo sapiens_hsa052211.73122120
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69375325
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.68624557
34Spliceosome_Homo sapiens_hsa030401.67887831
35Phagosome_Homo sapiens_hsa041451.67083873
36Rheumatoid arthritis_Homo sapiens_hsa053231.67046776
37Tuberculosis_Homo sapiens_hsa051521.63397244
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60373952
39ECM-receptor interaction_Homo sapiens_hsa045121.60047895
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56330330
41Homologous recombination_Homo sapiens_hsa034401.55067332
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45158228
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43094428
44Pertussis_Homo sapiens_hsa051331.42913677
45Systemic lupus erythematosus_Homo sapiens_hsa053221.42894278
46Antigen processing and presentation_Homo sapiens_hsa046121.40919964
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40796840
48Mineral absorption_Homo sapiens_hsa049781.39658967
49Chemokine signaling pathway_Homo sapiens_hsa040621.39501122
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37337165
51TNF signaling pathway_Homo sapiens_hsa046681.36501623
52Amoebiasis_Homo sapiens_hsa051461.36088733
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34880434
54Notch signaling pathway_Homo sapiens_hsa043301.33853119
55Legionellosis_Homo sapiens_hsa051341.31866438
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31711472
57TGF-beta signaling pathway_Homo sapiens_hsa043501.31173300
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.30743815
59Hedgehog signaling pathway_Homo sapiens_hsa043401.30134507
60Salmonella infection_Homo sapiens_hsa051321.29082790
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28946217
62Collecting duct acid secretion_Homo sapiens_hsa049661.28494603
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25027368
64Glycerolipid metabolism_Homo sapiens_hsa005611.24981081
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21580751
66Sulfur metabolism_Homo sapiens_hsa009201.20957915
67Tight junction_Homo sapiens_hsa045301.20925459
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20560870
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18108460
70PPAR signaling pathway_Homo sapiens_hsa033201.17663265
71One carbon pool by folate_Homo sapiens_hsa006701.16579785
72Ovarian steroidogenesis_Homo sapiens_hsa049131.15528781
73Apoptosis_Homo sapiens_hsa042101.14085123
74African trypanosomiasis_Homo sapiens_hsa051431.12870590
75Shigellosis_Homo sapiens_hsa051311.12021943
76Mismatch repair_Homo sapiens_hsa034301.11278971
77Cysteine and methionine metabolism_Homo sapiens_hsa002701.09042568
78Bladder cancer_Homo sapiens_hsa052191.08718500
79Renin-angiotensin system_Homo sapiens_hsa046141.08056748
80Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07046797
81Protein digestion and absorption_Homo sapiens_hsa049741.05564067
82* Influenza A_Homo sapiens_hsa051641.05483093
83Intestinal immune network for IgA production_Homo sapiens_hsa046721.04154215
84Pentose phosphate pathway_Homo sapiens_hsa000301.03449660
85Propanoate metabolism_Homo sapiens_hsa006401.03033209
86Pancreatic cancer_Homo sapiens_hsa052121.02507231
87Sphingolipid metabolism_Homo sapiens_hsa006001.02391105
88Focal adhesion_Homo sapiens_hsa045101.01193028
89Nucleotide excision repair_Homo sapiens_hsa034200.99978010
90Estrogen signaling pathway_Homo sapiens_hsa049150.98485113
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96829904
92DNA replication_Homo sapiens_hsa030300.96663968
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96366433
94Allograft rejection_Homo sapiens_hsa053300.95847645
95Renin secretion_Homo sapiens_hsa049240.95790971
96mTOR signaling pathway_Homo sapiens_hsa041500.95667280
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95615548
98Glucagon signaling pathway_Homo sapiens_hsa049220.95337568
99Hepatitis B_Homo sapiens_hsa051610.94329809
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93603961
101Basal cell carcinoma_Homo sapiens_hsa052170.92932907
102T cell receptor signaling pathway_Homo sapiens_hsa046600.92810958
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90198548
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89503745
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88212253
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87344747
107Complement and coagulation cascades_Homo sapiens_hsa046100.87197452
108Gap junction_Homo sapiens_hsa045400.87183997
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86866633
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.85157062
111Non-homologous end-joining_Homo sapiens_hsa034500.84159719
112Fatty acid degradation_Homo sapiens_hsa000710.82466676
113Adherens junction_Homo sapiens_hsa045200.82334667
114Axon guidance_Homo sapiens_hsa043600.81855750
115Non-small cell lung cancer_Homo sapiens_hsa052230.80744780
116Graft-versus-host disease_Homo sapiens_hsa053320.79671271
117Chronic myeloid leukemia_Homo sapiens_hsa052200.79460946
118Biosynthesis of amino acids_Homo sapiens_hsa012300.79370648
119Hippo signaling pathway_Homo sapiens_hsa043900.79147002
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78929910
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77809526
122Glutathione metabolism_Homo sapiens_hsa004800.76490005
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.76450385
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75714081
125Nitrogen metabolism_Homo sapiens_hsa009100.74604490
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73663823
127Thyroid hormone synthesis_Homo sapiens_hsa049180.72773532
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.72648473
129Toxoplasmosis_Homo sapiens_hsa051450.71791993
130HTLV-I infection_Homo sapiens_hsa051660.71274922
131Measles_Homo sapiens_hsa051620.70093217
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68978017
133* Herpes simplex infection_Homo sapiens_hsa051680.68849451
134VEGF signaling pathway_Homo sapiens_hsa043700.68246860
135RNA degradation_Homo sapiens_hsa030180.67416324
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66062785
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64733834
138Viral carcinogenesis_Homo sapiens_hsa052030.64137858
139Inositol phosphate metabolism_Homo sapiens_hsa005620.63405362
140Linoleic acid metabolism_Homo sapiens_hsa005910.63026850
141Alcoholism_Homo sapiens_hsa050340.62900480
142AMPK signaling pathway_Homo sapiens_hsa041520.62304045
143Wnt signaling pathway_Homo sapiens_hsa043100.62167747
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.61706177
145Autoimmune thyroid disease_Homo sapiens_hsa053200.60518405
146Vitamin B6 metabolism_Homo sapiens_hsa007500.58982873
147MicroRNAs in cancer_Homo sapiens_hsa052060.58693307
148Hepatitis C_Homo sapiens_hsa051600.58229883
149p53 signaling pathway_Homo sapiens_hsa041150.58201342
150Endocytosis_Homo sapiens_hsa041440.57757447
151Galactose metabolism_Homo sapiens_hsa000520.57482762
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.57377840
153Arachidonic acid metabolism_Homo sapiens_hsa005900.56694574
154Pathways in cancer_Homo sapiens_hsa052000.54905485
155Base excision repair_Homo sapiens_hsa034100.52672851
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52547261
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51974873
158Fatty acid elongation_Homo sapiens_hsa000620.49543695
159Insulin resistance_Homo sapiens_hsa049310.48674039
160Vascular smooth muscle contraction_Homo sapiens_hsa042700.48433255
161N-Glycan biosynthesis_Homo sapiens_hsa005100.46616964
162Epstein-Barr virus infection_Homo sapiens_hsa051690.46205109
163Viral myocarditis_Homo sapiens_hsa054160.45937757
164Neurotrophin signaling pathway_Homo sapiens_hsa047220.45413702
165Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44958030
166Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44619705
167Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44483415
168Glycerophospholipid metabolism_Homo sapiens_hsa005640.43845051
169Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43768854
170Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40569162
171cAMP signaling pathway_Homo sapiens_hsa040240.39571200
172Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39352738
173Bile secretion_Homo sapiens_hsa049760.38449610
174Carbon metabolism_Homo sapiens_hsa012000.37180540
175Proteoglycans in cancer_Homo sapiens_hsa052050.37168247
176Colorectal cancer_Homo sapiens_hsa052100.36554492
177Prostate cancer_Homo sapiens_hsa052150.35541340
178GnRH signaling pathway_Homo sapiens_hsa049120.35496740
179Thyroid cancer_Homo sapiens_hsa052160.34886524
180PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34788875
181Prolactin signaling pathway_Homo sapiens_hsa049170.34091776
182HIF-1 signaling pathway_Homo sapiens_hsa040660.33330348
183Primary immunodeficiency_Homo sapiens_hsa053400.32380906
184Vibrio cholerae infection_Homo sapiens_hsa051100.32352676

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