NXN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.61471715
2planar cell polarity pathway involved in neural tube closure (GO:0090179)4.36653932
3paraxial mesoderm development (GO:0048339)4.25030494
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.07919314
5G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.02478197
6viral transcription (GO:0019083)3.91265236
7translational termination (GO:0006415)3.80301523
8convergent extension (GO:0060026)3.75672076
9outer ear morphogenesis (GO:0042473)3.68551346
10protein heterotrimerization (GO:0070208)3.62453524
11chondrocyte proliferation (GO:0035988)3.59359970
12polarized epithelial cell differentiation (GO:0030859)3.53565510
13heterochromatin organization (GO:0070828)3.45191383
14collagen fibril organization (GO:0030199)3.41458685
15translational elongation (GO:0006414)3.34845120
16establishment of apical/basal cell polarity (GO:0035089)3.29222604
17skin morphogenesis (GO:0043589)3.28442878
18hippo signaling (GO:0035329)3.27558629
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16768789
20negative regulation of fatty acid transport (GO:2000192)3.15698552
21desmosome organization (GO:0002934)3.14926222
22endodermal cell differentiation (GO:0035987)3.14813886
23kidney mesenchyme development (GO:0072074)3.14023885
24regulation of hippo signaling (GO:0035330)3.05768966
25regulation of gene silencing by RNA (GO:0060966)3.03225308
26regulation of posttranscriptional gene silencing (GO:0060147)3.03225308
27regulation of gene silencing by miRNA (GO:0060964)3.03225308
28translational initiation (GO:0006413)3.00064353
29cellular protein complex disassembly (GO:0043624)2.99760772
30negative regulation of cell fate specification (GO:0009996)2.99475823
31cell-substrate junction assembly (GO:0007044)2.98706472
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98100390
33maturation of SSU-rRNA (GO:0030490)2.97405989
34bone trabecula formation (GO:0060346)2.97245127
35negative regulation of DNA repair (GO:0045738)2.96987227
36regulation of cardioblast differentiation (GO:0051890)2.95556834
37viral life cycle (GO:0019058)2.94443607
38ribosomal small subunit biogenesis (GO:0042274)2.92470609
39regulation of heart morphogenesis (GO:2000826)2.92247577
40protein targeting to ER (GO:0045047)2.91653495
41negative regulation of chondrocyte differentiation (GO:0032331)2.91594558
42cotranslational protein targeting to membrane (GO:0006613)2.87096715
43cochlea morphogenesis (GO:0090103)2.87035924
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.86434908
45lymphangiogenesis (GO:0001946)2.85103993
46notochord development (GO:0030903)2.84082308
47non-canonical Wnt signaling pathway (GO:0035567)2.83776233
48peptidyl-proline hydroxylation (GO:0019511)2.81333704
49protein complex disassembly (GO:0043241)2.80608437
50establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77617876
51epithelial cell-cell adhesion (GO:0090136)2.76255315
52regulation of establishment of planar polarity (GO:0090175)2.75475533
53lateral sprouting from an epithelium (GO:0060601)2.74290777
54positive regulation of endothelial cell apoptotic process (GO:2000353)2.73636793
55embryonic foregut morphogenesis (GO:0048617)2.73483481
56branching involved in salivary gland morphogenesis (GO:0060445)2.73181311
57establishment of monopolar cell polarity (GO:0061162)2.73128080
58establishment or maintenance of monopolar cell polarity (GO:0061339)2.73128080
59middle ear morphogenesis (GO:0042474)2.72974449
60ribosomal small subunit assembly (GO:0000028)2.70198576
61regulation of SMAD protein import into nucleus (GO:0060390)2.70041432
62negative regulation of axon extension involved in axon guidance (GO:0048843)2.69791068
63cell migration involved in sprouting angiogenesis (GO:0002042)2.67646287
64establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.66883547
65positive regulation of SMAD protein import into nucleus (GO:0060391)2.66349768
66lung-associated mesenchyme development (GO:0060484)2.65882258
67embryonic cranial skeleton morphogenesis (GO:0048701)2.65794124
68regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.62215234
69protein localization to endoplasmic reticulum (GO:0070972)2.61874249
70regulation of cell fate specification (GO:0042659)2.61100293
71plasma membrane repair (GO:0001778)2.60298512
72negative regulation of cartilage development (GO:0061037)2.57603015
73DNA unwinding involved in DNA replication (GO:0006268)2.57524504
74anterior/posterior axis specification, embryo (GO:0008595)2.56823927
75nuclear pore complex assembly (GO:0051292)2.55875124
76mesenchymal-epithelial cell signaling (GO:0060638)2.55751600
77macromolecular complex disassembly (GO:0032984)2.55622125
78heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.54658468
79artery development (GO:0060840)2.54597107
80negative regulation of embryonic development (GO:0045992)2.53571827
81positive regulation of epithelial to mesenchymal transition (GO:0010718)2.53249134
82cell migration involved in gastrulation (GO:0042074)2.53058035
83protein hydroxylation (GO:0018126)2.52422263
84ventricular cardiac muscle cell development (GO:0055015)2.52242922
85regulation of transforming growth factor beta2 production (GO:0032909)2.51847248
86regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51681887
87negative regulation of keratinocyte proliferation (GO:0010839)2.50540718
88dorsal/ventral axis specification (GO:0009950)2.49788086
89mesenchyme development (GO:0060485)2.49143276
90DNA replication-dependent nucleosome assembly (GO:0006335)2.49044952
91DNA replication-dependent nucleosome organization (GO:0034723)2.49044952
92regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.48820222
93wound healing, spreading of epidermal cells (GO:0035313)2.48385781
94embryonic camera-type eye development (GO:0031076)2.48334968
95atrioventricular valve morphogenesis (GO:0003181)2.47713833
96establishment of planar polarity (GO:0001736)2.47430608
97establishment of tissue polarity (GO:0007164)2.47430608
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.47271384
99axon extension involved in axon guidance (GO:0048846)2.47271384
100renal system development (GO:0072001)2.47114847
101nuclear pore organization (GO:0006999)2.46021094
102proximal/distal pattern formation (GO:0009954)2.45109486
103cell migration involved in heart development (GO:0060973)2.43955408
104craniofacial suture morphogenesis (GO:0097094)2.43778344
105L-serine metabolic process (GO:0006563)2.43023423
106body morphogenesis (GO:0010171)2.42149778
107establishment or maintenance of apical/basal cell polarity (GO:0035088)2.41822056
108establishment or maintenance of bipolar cell polarity (GO:0061245)2.41822056
109endothelial cell morphogenesis (GO:0001886)2.41465698
110gap junction assembly (GO:0016264)2.40379778
111mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39520119
112ribosomal large subunit biogenesis (GO:0042273)2.39159361
113atrial septum morphogenesis (GO:0060413)2.38106943
114regulation of cardioblast proliferation (GO:0003264)2.37844073
115regulation of secondary heart field cardioblast proliferation (GO:0003266)2.37844073
116regulation of mesoderm development (GO:2000380)2.37086527
117sequestering of extracellular ligand from receptor (GO:0035581)2.36865922
118regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.36534345
119mesenchymal cell proliferation (GO:0010463)2.36493204
120interferon-gamma secretion (GO:0072643)2.35905345
121embryonic skeletal joint morphogenesis (GO:0060272)2.35808664
122actin-myosin filament sliding (GO:0033275)2.35748481
123muscle filament sliding (GO:0030049)2.35748481
124basement membrane organization (GO:0071711)2.35633570
125embryonic body morphogenesis (GO:0010172)2.34971954
126metanephric mesenchyme development (GO:0072075)2.34839761
127adherens junction assembly (GO:0034333)2.34616973
128negative regulation of axon guidance (GO:1902668)2.34130433
129eyelid development in camera-type eye (GO:0061029)2.33069492
130endocardial cushion development (GO:0003197)2.32937901
131binding of sperm to zona pellucida (GO:0007339)2.32211868
132regulation of catenin import into nucleus (GO:0035412)2.31795048
133positive regulation of catenin import into nucleus (GO:0035413)2.31471987
134negative regulation of stem cell proliferation (GO:2000647)2.30893901
135mesenchymal to epithelial transition (GO:0060231)2.29239322
136actin-mediated cell contraction (GO:0070252)2.27357604
137negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.26860824
138positive regulation of gastrulation (GO:2000543)2.25459727
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.23895718
140regulation of gastrulation (GO:0010470)2.23076031
141tooth mineralization (GO:0034505)2.23038686
142negative regulation of androgen receptor signaling pathway (GO:0060766)2.22532787
143regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.22270968
144regulation of hair follicle development (GO:0051797)2.21400525
145cardiac myofibril assembly (GO:0055003)2.21157715
146dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21044942
147generation of neurons (GO:0048699)2.19061535
148neural tube development (GO:0021915)2.18079639
149nodal signaling pathway (GO:0038092)2.17482179
150muscle cell fate commitment (GO:0042693)2.17269921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.39506251
2E2F7_22180533_ChIP-Seq_HELA_Human3.82800505
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.49206367
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.22098133
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.17909334
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.95732519
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83333032
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80995309
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77039917
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73924626
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.64574817
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.56592246
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38244933
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35172647
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.32003682
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.21775060
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.07647530
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04364660
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.97713010
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.97713010
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.97713010
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96688608
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95621655
24ZNF263_19887448_ChIP-Seq_K562_Human1.89867480
25* EED_16625203_ChIP-ChIP_MESCs_Mouse1.87687155
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85199665
27CLOCK_20551151_ChIP-Seq_293T_Human1.84459964
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83632335
29AR_21909140_ChIP-Seq_LNCAP_Human1.83120330
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79412260
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78205687
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74393749
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.73019788
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69800783
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69385284
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68776876
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65982700
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65982700
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64342836
40TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62652392
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.62337108
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61659876
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60432655
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59669803
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59669803
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58389615
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.55471519
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52673115
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52530903
50XRN2_22483619_ChIP-Seq_HELA_Human1.52437915
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.51439657
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51331329
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.50654827
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47108435
55* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46990185
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45575958
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42741986
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42075015
59* ATF3_27146783_Chip-Seq_COLON_Human1.39459592
60* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39097527
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39081058
62UBF1/2_26484160_Chip-Seq_HMECs_Human1.38978517
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37898207
64MYC_22102868_ChIP-Seq_BL_Human1.37745796
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37581767
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.37567453
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.37013350
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35145377
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34773538
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34667730
71TP53_22127205_ChIP-Seq_IMR90_Human1.32241768
72* RING1B_27294783_Chip-Seq_NPCs_Mouse1.30380169
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30352660
74* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29750236
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29665274
76* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28319057
77RACK7_27058665_Chip-Seq_MCF-7_Human1.26082026
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25106874
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24783778
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.24670299
81BRD4_25478319_ChIP-Seq_HGPS_Human1.24170910
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23804227
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.22954683
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22904199
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20352391
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.19124876
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15427651
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12617123
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12449735
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12109665
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11780150
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11126208
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10545111
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09964571
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09017873
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08649228
97JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08159306
98ESR1_21235772_ChIP-Seq_MCF-7_Human1.07452478
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06512018
100TTF2_22483619_ChIP-Seq_HELA_Human1.05445494
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04432794
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04017859
103TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03963074
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03175247
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03154567
106* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02827909
107* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01676641
108* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01600004
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01446844
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00487518
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.00128395
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99997178
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99842378
114* CTCF_27219007_Chip-Seq_Bcells_Human0.99802683
115JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99732351
116MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99523641
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99303307
118KDM2B_26808549_Chip-Seq_DND41_Human0.99256847
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99124347
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98385745
121* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97625949
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.97232305
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97106661
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96819439
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.96230679
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96064444
127EZH2_27294783_Chip-Seq_ESCs_Mouse0.95565816
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95149447
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94624189
130TCF7_22412390_ChIP-Seq_EML_Mouse0.94213682
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94184635
132* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93794356
133NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93411288
134NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92625240
135CHD1_26751641_Chip-Seq_LNCaP_Human0.92396418
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.92247077
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.91319934
138* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90794482
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.90058959
140E2F1_21310950_ChIP-Seq_MCF-7_Human0.89558872
141* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88894703
142POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88797614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.88690714
2MP0005275_abnormal_skin_tensile3.47648791
3MP0010030_abnormal_orbit_morphology3.40553342
4MP0003705_abnormal_hypodermis_morpholog3.20499792
5MP0005503_abnormal_tendon_morphology2.65544581
6MP0005623_abnormal_meninges_morphology2.60668906
7MP0009053_abnormal_anal_canal2.39058711
8MP0003941_abnormal_skin_development2.36354038
9MP0004272_abnormal_basement_membrane2.19410997
10MP0003566_abnormal_cell_adhesion2.18259492
11MP0010352_gastrointestinal_tract_polyps2.15580005
12MP0000537_abnormal_urethra_morphology2.12318124
13MP0003385_abnormal_body_wall1.92816770
14MP0009250_abnormal_appendicular_skeleto1.89431151
15MP0000751_myopathy1.84030417
16MP0010234_abnormal_vibrissa_follicle1.83408881
17MP0003279_aneurysm1.83160139
18MP0000733_abnormal_muscle_development1.82599345
19MP0002282_abnormal_trachea_morphology1.77996581
20MP0002060_abnormal_skin_morphology1.77905737
21MP0005508_abnormal_skeleton_morphology1.74212328
22MP0000762_abnormal_tongue_morphology1.73880198
23MP0000049_abnormal_middle_ear1.71809008
24MP0005076_abnormal_cell_differentiation1.63641579
25MP0004133_heterotaxia1.61914118
26MP0003942_abnormal_urinary_system1.61132751
27MP0006054_spinal_hemorrhage1.61051105
28MP0001849_ear_inflammation1.54561785
29MP0005023_abnormal_wound_healing1.52396159
30MP0003755_abnormal_palate_morphology1.51710515
31MP0000428_abnormal_craniofacial_morphol1.50641019
32MP0002877_abnormal_melanocyte_morpholog1.49493726
33MP0000534_abnormal_ureter_morphology1.48954296
34MP0003890_abnormal_embryonic-extraembry1.48823444
35MP0002796_impaired_skin_barrier1.46369141
36MP0010368_abnormal_lymphatic_system1.45103519
37MP0000467_abnormal_esophagus_morphology1.43976607
38MP0003950_abnormal_plasma_membrane1.41699337
39MP0002932_abnormal_joint_morphology1.40136915
40MP0003937_abnormal_limbs/digits/tail_de1.39288032
41MP0002234_abnormal_pharynx_morphology1.38065059
42MP0002249_abnormal_larynx_morphology1.37686434
43MP0009384_cardiac_valve_regurgitation1.37644340
44MP0000516_abnormal_urinary_system1.36963956
45MP0005367_renal/urinary_system_phenotyp1.36963956
46MP0001299_abnormal_eye_distance/1.35681780
47MP0006292_abnormal_olfactory_placode1.35114735
48MP0008007_abnormal_cellular_replicative1.31450178
49MP0002697_abnormal_eye_size1.28197846
50MP0002653_abnormal_ependyma_morphology1.27278045
51MP0000749_muscle_degeneration1.26272285
52MP0001958_emphysema1.24775930
53MP0005257_abnormal_intraocular_pressure1.24106153
54MP0005501_abnormal_skin_physiology1.23428718
55MP0003935_abnormal_craniofacial_develop1.21423579
56MP0002233_abnormal_nose_morphology1.21142348
57MP0004957_abnormal_blastocyst_morpholog1.17855661
58MP0002938_white_spotting1.16288474
59MP0004858_abnormal_nervous_system1.16184079
60MP0002111_abnormal_tail_morphology1.15523483
61MP0000432_abnormal_head_morphology1.15343026
62MP0003115_abnormal_respiratory_system1.14075103
63MP0003123_paternal_imprinting1.11813328
64MP0000750_abnormal_muscle_regeneration1.10749733
65MP0002116_abnormal_craniofacial_bone1.10091848
66MP0001346_abnormal_lacrimal_gland1.09607701
67MP0002084_abnormal_developmental_patter1.09024661
68MP0004197_abnormal_fetal_growth/weight/1.08974324
69MP0003111_abnormal_nucleus_morphology1.08527041
70MP0002085_abnormal_embryonic_tissue1.07768071
71MP0000579_abnormal_nail_morphology1.07559534
72MP0000566_synostosis1.04709900
73MP0000462_abnormal_digestive_system1.04027666
74MP0004233_abnormal_muscle_weight1.02650406
75MP0000759_abnormal_skeletal_muscle1.02485864
76MP0003091_abnormal_cell_migration1.02435705
77MP0002108_abnormal_muscle_morphology1.02239681
78MP0002177_abnormal_outer_ear1.01754219
79MP0000350_abnormal_cell_proliferation1.00697426
80MP0008932_abnormal_embryonic_tissue0.99690899
81MP0001348_abnormal_lacrimal_gland0.99584105
82MP0005410_abnormal_fertilization0.99254763
83MP0005394_taste/olfaction_phenotype0.99065866
84MP0005499_abnormal_olfactory_system0.99065866
85MP0003453_abnormal_keratinocyte_physiol0.98827184
86MP0002092_abnormal_eye_morphology0.98259071
87MP0009379_abnormal_foot_pigmentation0.97658275
88MP0004145_abnormal_muscle_electrophysio0.97026556
89MP0003861_abnormal_nervous_system0.96829493
90MP0003119_abnormal_digestive_system0.96703707
91MP0004087_abnormal_muscle_fiber0.95071741
92MP0000163_abnormal_cartilage_morphology0.94917973
93MP0002109_abnormal_limb_morphology0.94679453
94MP0000778_abnormal_nervous_system0.94326335
95MP0000377_abnormal_hair_follicle0.93978066
96MP0002098_abnormal_vibrissa_morphology0.93666275
97MP0001293_anophthalmia0.93539988
98MP0005197_abnormal_uvea_morphology0.92562950
99MP0002896_abnormal_bone_mineralization0.91753131
100MP0002254_reproductive_system_inflammat0.91528696
101MP0008789_abnormal_olfactory_epithelium0.91333568
102MP0002114_abnormal_axial_skeleton0.91286343
103MP0001243_abnormal_dermal_layer0.90764072
104MP0003283_abnormal_digestive_organ0.90724914
105MP0009672_abnormal_birth_weight0.90338352
106MP0001730_embryonic_growth_arrest0.88004422
107MP0010678_abnormal_skin_adnexa0.86811699
108MP0003077_abnormal_cell_cycle0.86769903
109MP0010771_integument_phenotype0.86584050
110MP0000383_abnormal_hair_follicle0.86522551
111MP0001340_abnormal_eyelid_morphology0.85986507
112MP0002115_abnormal_skeleton_extremities0.85852993
113MP0001286_abnormal_eye_development0.84978781
114MP0003122_maternal_imprinting0.83129910
115MP0001697_abnormal_embryo_size0.82923200
116MP0003315_abnormal_perineum_morphology0.82834864
117MP0001216_abnormal_epidermal_layer0.82757273
118MP0002925_abnormal_cardiovascular_devel0.82464448
119MP0003938_abnormal_ear_development0.82049655
120MP0000767_abnormal_smooth_muscle0.80972546
121MP0005193_abnormal_anterior_eye0.80632148
122MP0005369_muscle_phenotype0.80472296
123MP0005380_embryogenesis_phenotype0.80260112
124MP0001672_abnormal_embryogenesis/_devel0.80260112
125MP0003646_muscle_fatigue0.80187497
126MP0005620_abnormal_muscle_contractility0.78509470
127* MP0002081_perinatal_lethality0.76144640
128MP0003567_abnormal_fetal_cardiomyocyte0.72559125
129MP0003693_abnormal_embryo_hatching0.72420767
130MP0001879_abnormal_lymphatic_vessel0.71880494

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.37950553
2Protrusio acetabuli (HP:0003179)5.34609867
3Atrophic scars (HP:0001075)4.15147614
4Shallow orbits (HP:0000586)4.05986604
5Fragile skin (HP:0001030)3.20797672
6Ankle contracture (HP:0006466)3.19989249
7Selective tooth agenesis (HP:0001592)3.16166815
8Abnormality of dentin (HP:0010299)2.96235614
9Nemaline bodies (HP:0003798)2.94312718
10Aortic dissection (HP:0002647)2.90487154
11Soft skin (HP:0000977)2.78649858
12Cerebral aneurysm (HP:0004944)2.77761097
13Type 1 muscle fiber predominance (HP:0003803)2.77749248
14Neonatal short-limb short stature (HP:0008921)2.71805981
15Fragile nails (HP:0001808)2.65299871
16Increased connective tissue (HP:0009025)2.61906823
17Vascular tortuosity (HP:0004948)2.61408482
18Bladder diverticulum (HP:0000015)2.59810877
19Milia (HP:0001056)2.57816691
20Genu recurvatum (HP:0002816)2.53809665
21Peritonitis (HP:0002586)2.53159556
22Spinal rigidity (HP:0003306)2.53140105
23Dilatation of the ascending aorta (HP:0005111)2.43920912
24Arterial tortuosity (HP:0005116)2.42867536
25Short 4th metacarpal (HP:0010044)2.42297991
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42297991
27Broad metatarsal (HP:0001783)2.37559688
28Deviation of the hallux (HP:0010051)2.30100006
29Wrist flexion contracture (HP:0001239)2.29573508
30Aortic aneurysm (HP:0004942)2.27636647
31Abnormality of the calcaneus (HP:0008364)2.22823777
32Natal tooth (HP:0000695)2.21553926
33Hallux valgus (HP:0001822)2.21006977
34Difficulty climbing stairs (HP:0003551)2.19582969
35Pterygium (HP:0001059)2.18870165
36Calcaneovalgus deformity (HP:0001848)2.16203474
37Trismus (HP:0000211)2.14695946
38Short nail (HP:0001799)2.14570479
39Mitral valve prolapse (HP:0001634)2.14489485
40Partial duplication of the phalanx of hand (HP:0009999)2.13375372
41Cervical subluxation (HP:0003308)2.12784004
42Wormian bones (HP:0002645)2.12744114
43Turricephaly (HP:0000262)2.09699200
44Mesomelia (HP:0003027)2.09632993
45Bowel diverticulosis (HP:0005222)2.08972250
46Scapular winging (HP:0003691)2.08500097
47Coronal craniosynostosis (HP:0004440)2.07829222
48Partial duplication of thumb phalanx (HP:0009944)2.07366289
49Round ear (HP:0100830)2.07120739
50Blue sclerae (HP:0000592)2.06596500
51Increased density of long bones (HP:0006392)2.06174078
52Deformed tarsal bones (HP:0008119)2.04396014
53Right ventricular cardiomyopathy (HP:0011663)2.03885907
54Down-sloping shoulders (HP:0200021)2.01029841
55Missing ribs (HP:0000921)1.99684144
56Elbow flexion contracture (HP:0002987)1.98073782
57Renal duplication (HP:0000075)1.94152814
58Buphthalmos (HP:0000557)1.94144474
59Slender build (HP:0001533)1.92448913
60Ulnar bowing (HP:0003031)1.91700303
61Abnormality of the 4th metacarpal (HP:0010012)1.91341205
62Abnormality of the distal phalanges of the toes (HP:0010182)1.90526208
63Preaxial foot polydactyly (HP:0001841)1.86558699
64Onycholysis (HP:0001806)1.85145582
65Woolly hair (HP:0002224)1.84483769
66Septo-optic dysplasia (HP:0100842)1.83569296
67Radial bowing (HP:0002986)1.82624260
68Abnormality of the 2nd finger (HP:0004100)1.81594698
69Mitral regurgitation (HP:0001653)1.81011067
70Overgrowth (HP:0001548)1.80964181
71Hypoplastic labia majora (HP:0000059)1.80028922
72Cutaneous finger syndactyly (HP:0010554)1.78932365
73Broad toe (HP:0001837)1.78649014
74Esophageal atresia (HP:0002032)1.78629123
75Abnormality of the aortic arch (HP:0012303)1.77770820
76Morphological abnormality of the middle ear (HP:0008609)1.77501361
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76807258
78Broad thumb (HP:0011304)1.76347713
79Wide anterior fontanel (HP:0000260)1.75243225
80Muscle fiber inclusion bodies (HP:0100299)1.74917765
81Abnormality of the labia majora (HP:0012881)1.73660501
82Mildly elevated creatine phosphokinase (HP:0008180)1.73513727
83Achilles tendon contracture (HP:0001771)1.73063683
84Cutaneous syndactyly (HP:0012725)1.72669956
85Aplasia involving bones of the upper limbs (HP:0009823)1.72103882
86Aplasia of the phalanges of the hand (HP:0009802)1.72103882
87Aplasia involving bones of the extremities (HP:0009825)1.72103882
88High anterior hairline (HP:0009890)1.71615791
89Hyperacusis (HP:0010780)1.69909278
90Myelomeningocele (HP:0002475)1.69822675
91Ulnar deviation of the wrist (HP:0003049)1.69498156
92Distal lower limb muscle weakness (HP:0009053)1.68674562
93Tarsal synostosis (HP:0008368)1.68263079
94Myopathic facies (HP:0002058)1.68134805
95Asymmetry of the thorax (HP:0001555)1.67966932
96Broad long bones (HP:0005622)1.66883390
97Limited hip movement (HP:0008800)1.66771620
98Abnormality of skeletal muscle fiber size (HP:0012084)1.66009033
99Hip contracture (HP:0003273)1.65051005
100Abnormality of the acetabulum (HP:0003170)1.64936007
101Hyperextensible skin (HP:0000974)1.64836648
102Biconcave vertebral bodies (HP:0004586)1.64130360
103Bowing of the arm (HP:0006488)1.62771627
104Bowed forearm bones (HP:0003956)1.62771627
105Hypotrichosis (HP:0001006)1.61717871
106Atresia of the external auditory canal (HP:0000413)1.61372831
107Microglossia (HP:0000171)1.60568281
108Fibular aplasia (HP:0002990)1.59913608
109Fused cervical vertebrae (HP:0002949)1.59851787
110Distal lower limb amyotrophy (HP:0008944)1.59430688
111Rectal prolapse (HP:0002035)1.59285370
112Thin bony cortex (HP:0002753)1.58663297
113Follicular hyperkeratosis (HP:0007502)1.58385681
114Bronchomalacia (HP:0002780)1.58020422
115Broad distal phalanx of finger (HP:0009836)1.57407893
116Breech presentation (HP:0001623)1.57292734
117Pili torti (HP:0003777)1.56992789
118Advanced eruption of teeth (HP:0006288)1.56981958
119Broad phalanx (HP:0006009)1.56503162
120Hypoventilation (HP:0002791)1.56371688
121Distal arthrogryposis (HP:0005684)1.56317775
122Arnold-Chiari malformation (HP:0002308)1.56183271
123Reticulocytopenia (HP:0001896)1.56081658
124Abnormality of the peritoneum (HP:0002585)1.55891671
125Exercise-induced muscle cramps (HP:0003710)1.55859936
126Increased variability in muscle fiber diameter (HP:0003557)1.55661158
127Broad hallux (HP:0010055)1.55117833
128Abdominal situs inversus (HP:0003363)1.55060743
129Abnormality of abdominal situs (HP:0011620)1.55060743
130Duplication of thumb phalanx (HP:0009942)1.55024006
131Maternal diabetes (HP:0009800)1.54822951
132Absent eyelashes (HP:0000561)1.52612809
133Broad phalanges of the hand (HP:0009768)1.52563054
134Broad finger (HP:0001500)1.52541219
135Overriding aorta (HP:0002623)1.50725411
136Synostosis of carpal bones (HP:0005048)1.50582773
137Joint laxity (HP:0001388)1.50563625
138Myotonia (HP:0002486)1.49648377
139Thin ribs (HP:0000883)1.49240986
140Limb-girdle muscle weakness (HP:0003325)1.48285461
141Anophthalmia (HP:0000528)1.47221574
142Disproportionate tall stature (HP:0001519)1.45468591
143Choanal stenosis (HP:0000452)1.44502943
144Abnormality of the umbilical cord (HP:0010881)1.43487663
145Bifid tongue (HP:0010297)1.43437403
146Short hallux (HP:0010109)1.42908530
147Hydroureter (HP:0000072)1.41668761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.73439304
2EEF2K3.26069846
3TTN3.13834519
4PKN22.86654804
5EPHB22.79430900
6TESK12.77291065
7DDR22.31156157
8LATS22.30588936
9LATS12.26412392
10NTRK12.09795197
11PDGFRA2.08843291
12MAP3K102.06159698
13VRK22.01038903
14PNCK1.95532960
15OBSCN1.94400463
16PAK41.86677853
17TLK11.85751265
18RPS6KB21.83847159
19PAK21.79396754
20LRRK21.76716859
21SMG11.76332767
22PDK41.72651493
23PDK31.72651493
24NEK21.67606759
25EPHA21.67534089
26PTK61.65295456
27FER1.64784060
28MAPKAPK31.61175045
29TAF11.55497587
30TGFBR11.49054558
31PIM21.48215026
32PBK1.36511882
33NEK11.35550261
34ILK1.34711243
35CAMK1G1.34153123
36PRKD31.30405461
37CDC71.28903274
38RIPK11.28032878
39ICK1.26178092
40PTK21.25786455
41DYRK1B1.24490356
42ERBB41.23454927
43TIE11.22557212
44CDK121.22037154
45BUB11.21273535
46RPS6KA41.16939757
47STK31.15213286
48MAP3K31.13622408
49STK101.13230046
50PDK21.13070481
51PHKG11.12685996
52PHKG21.12685996
53DYRK31.12131828
54ERN11.08226639
55WEE11.07958071
56PASK1.06870306
57LIMK11.06820367
58MTOR1.06663883
59MAP3K91.06076170
60BMX1.05612982
61TNIK1.04532690
62CDK61.04388136
63FGFR11.01059198
64CDK80.99895881
65MAP3K80.98560793
66CDK70.98454801
67DMPK0.95247643
68MKNK10.94312040
69MET0.92859777
70PLK40.91438129
71CAMK1D0.89426932
72TESK20.88406463
73TTK0.88125080
74NME10.86892164
75DYRK20.86575527
76MST1R0.85374735
77STK38L0.83540780
78SIK10.78021184
79ALK0.75280576
80PAK10.75125422
81DAPK30.74875495
82FLT30.74184599
83TRPM70.71713665
84AURKB0.70479380
85PTK2B0.68735765
86NME20.68057582
87MELK0.68027696
88TYRO30.67055771
89ERBB30.66712022
90SCYL20.63965354
91RPS6KA20.61597027
92PLK10.61417013
93ADRBK10.61355211
94ROCK10.61263369
95MARK10.60333198
96EPHA30.58407550
97TSSK60.57190970
98PDGFRB0.55975972
99CASK0.54684374
100BRAF0.54188027
101STK240.53537835
102PRKD20.50731894
103ERBB20.50429882
104CHEK10.50382264
105NEK90.49235990
106MKNK20.48538849
107AURKA0.48248930
108CSNK1G10.48028862
109MAP2K30.47541674
110ROCK20.46937619
111PLK30.46449251
112MAP3K70.44353540
113STK160.42228358
114CDC42BPA0.41688211
115BRSK10.40981048
116AKT20.39983126
117MAPKAPK20.39954784
118FGFR20.39861275
119MAP3K20.39815572
120CDK90.39676047
121PRKCI0.39592617
122PRKG20.39541659
123WNK10.39277173
124RPS6KC10.38967662
125RPS6KL10.38967662
126MOS0.38222426
127SRPK10.37853678
128ATR0.37845695
129CAMK2G0.36127387
130MAP2K20.35884637
131PIK3CG0.35598846
132RPS6KA10.35187831
133CHEK20.35121625
134CDK11A0.35009123
135CDK140.34990746
136CSNK1E0.34757693
137CDK150.33798207
138CDK40.32561067
139CDK20.32411190
140MYLK0.32022325

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.90888564
2Basal cell carcinoma_Homo sapiens_hsa052172.73415348
3ECM-receptor interaction_Homo sapiens_hsa045122.58151107
4Hippo signaling pathway_Homo sapiens_hsa043902.38023542
5Bladder cancer_Homo sapiens_hsa052192.21880243
6Focal adhesion_Homo sapiens_hsa045102.09417910
7Hedgehog signaling pathway_Homo sapiens_hsa043402.06054188
8p53 signaling pathway_Homo sapiens_hsa041152.05788352
9Proteoglycans in cancer_Homo sapiens_hsa052052.00198733
10TGF-beta signaling pathway_Homo sapiens_hsa043501.97081413
11Small cell lung cancer_Homo sapiens_hsa052221.91623863
12Adherens junction_Homo sapiens_hsa045201.88043206
13RNA transport_Homo sapiens_hsa030131.87922178
14Cell cycle_Homo sapiens_hsa041101.84604151
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.83084152
16MicroRNAs in cancer_Homo sapiens_hsa052061.82027285
17Spliceosome_Homo sapiens_hsa030401.74492321
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73731401
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70601112
20DNA replication_Homo sapiens_hsa030301.57234750
21Chronic myeloid leukemia_Homo sapiens_hsa052201.55258553
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49999910
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49518751
24Wnt signaling pathway_Homo sapiens_hsa043101.43935675
25Tight junction_Homo sapiens_hsa045301.43756130
26mRNA surveillance pathway_Homo sapiens_hsa030151.39914206
27HTLV-I infection_Homo sapiens_hsa051661.39696135
28Sulfur relay system_Homo sapiens_hsa041221.39226075
29Amoebiasis_Homo sapiens_hsa051461.36141246
30One carbon pool by folate_Homo sapiens_hsa006701.33774194
31Thyroid cancer_Homo sapiens_hsa052161.32962203
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.31671793
33Melanoma_Homo sapiens_hsa052181.29231383
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28074593
35Notch signaling pathway_Homo sapiens_hsa043301.26774172
36Biosynthesis of amino acids_Homo sapiens_hsa012301.26052658
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24918699
38Pathways in cancer_Homo sapiens_hsa052001.22914334
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21274524
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17369905
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17171445
42Protein digestion and absorption_Homo sapiens_hsa049741.16424067
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.14718403
44Viral carcinogenesis_Homo sapiens_hsa052031.13926718
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12885751
46Steroid biosynthesis_Homo sapiens_hsa001001.11876739
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11675015
48Prostate cancer_Homo sapiens_hsa052151.09542635
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08406750
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07145673
51Melanogenesis_Homo sapiens_hsa049161.06438796
52Dilated cardiomyopathy_Homo sapiens_hsa054141.04924771
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04848141
54Selenocompound metabolism_Homo sapiens_hsa004501.04289620
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.03263766
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99231473
57Mismatch repair_Homo sapiens_hsa034300.99184494
58Cardiac muscle contraction_Homo sapiens_hsa042600.98817929
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98199169
60Base excision repair_Homo sapiens_hsa034100.98168513
61Colorectal cancer_Homo sapiens_hsa052100.97168936
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.96239529
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95578533
64Oocyte meiosis_Homo sapiens_hsa041140.94364943
65Arginine and proline metabolism_Homo sapiens_hsa003300.93086781
66Glioma_Homo sapiens_hsa052140.92511668
67Endometrial cancer_Homo sapiens_hsa052130.91873241
68Viral myocarditis_Homo sapiens_hsa054160.90111448
69Nucleotide excision repair_Homo sapiens_hsa034200.88281417
70HIF-1 signaling pathway_Homo sapiens_hsa040660.87777760
71Systemic lupus erythematosus_Homo sapiens_hsa053220.84570820
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83217399
73VEGF signaling pathway_Homo sapiens_hsa043700.82764158
74Lysine degradation_Homo sapiens_hsa003100.82297103
75Axon guidance_Homo sapiens_hsa043600.82256651
76Pyruvate metabolism_Homo sapiens_hsa006200.82243882
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80165684
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79634114
79Rap1 signaling pathway_Homo sapiens_hsa040150.79582507
80mTOR signaling pathway_Homo sapiens_hsa041500.78635148
81Carbon metabolism_Homo sapiens_hsa012000.78635130
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77288474
83Estrogen signaling pathway_Homo sapiens_hsa049150.76661620
84RNA polymerase_Homo sapiens_hsa030200.76222139
85Pancreatic cancer_Homo sapiens_hsa052120.75958851
86Antigen processing and presentation_Homo sapiens_hsa046120.75388108
87Non-homologous end-joining_Homo sapiens_hsa034500.75369846
88Vitamin B6 metabolism_Homo sapiens_hsa007500.75295885
89Galactose metabolism_Homo sapiens_hsa000520.74372239
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73693509
91Toxoplasmosis_Homo sapiens_hsa051450.73206689
92Shigellosis_Homo sapiens_hsa051310.73105294
93Homologous recombination_Homo sapiens_hsa034400.69556450
94Basal transcription factors_Homo sapiens_hsa030220.69401826
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68954251
96Fanconi anemia pathway_Homo sapiens_hsa034600.68827395
97Apoptosis_Homo sapiens_hsa042100.68590840
98Epstein-Barr virus infection_Homo sapiens_hsa051690.66755426
99Proteasome_Homo sapiens_hsa030500.66717169
100Renal cell carcinoma_Homo sapiens_hsa052110.66667282
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66269113
102Acute myeloid leukemia_Homo sapiens_hsa052210.63976509
103RNA degradation_Homo sapiens_hsa030180.63342025
104Alcoholism_Homo sapiens_hsa050340.62817334
105Non-small cell lung cancer_Homo sapiens_hsa052230.62028296
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60145787
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60050832
108Pentose phosphate pathway_Homo sapiens_hsa000300.59901638
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.59683133
110Hepatitis B_Homo sapiens_hsa051610.56364736
111Folate biosynthesis_Homo sapiens_hsa007900.56172886
112Glucagon signaling pathway_Homo sapiens_hsa049220.55596641
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55380320
114Pyrimidine metabolism_Homo sapiens_hsa002400.55084566
115Platelet activation_Homo sapiens_hsa046110.52633363
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51299683
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51265424
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49015499
119AMPK signaling pathway_Homo sapiens_hsa041520.47612863
120Malaria_Homo sapiens_hsa051440.47392968
121Propanoate metabolism_Homo sapiens_hsa006400.45732920
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45001155
123Gap junction_Homo sapiens_hsa045400.44952542
124Insulin signaling pathway_Homo sapiens_hsa049100.43925805
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43176597
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42406620
127TNF signaling pathway_Homo sapiens_hsa046680.41941132
128N-Glycan biosynthesis_Homo sapiens_hsa005100.41548162
129Glutathione metabolism_Homo sapiens_hsa004800.41266668
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40993892
131FoxO signaling pathway_Homo sapiens_hsa040680.40736859
132Herpes simplex infection_Homo sapiens_hsa051680.39344358
133Purine metabolism_Homo sapiens_hsa002300.38009240
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.35740673

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