NXNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GMP metabolic process (GO:0046037)9.76486657
2regulation of guanylate cyclase activity (GO:0031282)9.52395516
3protein-chromophore linkage (GO:0018298)9.07003132
4retinal rod cell development (GO:0046548)9.06373606
5visual perception (GO:0007601)8.74427917
6sensory perception of light stimulus (GO:0050953)8.65277938
7cellular response to light stimulus (GO:0071482)7.54900950
8photoreceptor cell differentiation (GO:0046530)7.49141240
9eye photoreceptor cell differentiation (GO:0001754)7.49141240
10detection of external stimulus (GO:0009581)7.03576058
11detection of abiotic stimulus (GO:0009582)6.92025520
12regulation of cGMP metabolic process (GO:0030823)6.73350936
13retina development in camera-type eye (GO:0060041)6.51111772
14positive regulation of cGMP biosynthetic process (GO:0030828)6.20022269
15regulation of cGMP biosynthetic process (GO:0030826)5.84557528
16positive regulation of cGMP metabolic process (GO:0030825)5.50060274
17pyrimidine nucleobase catabolic process (GO:0006208)5.45465451
18detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.30098722
19nonmotile primary cilium assembly (GO:0035058)5.25123043
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.14923109
21receptor guanylyl cyclase signaling pathway (GO:0007168)5.14727549
22cell morphogenesis involved in neuron differentiation (GO:0048667)5.07665608
23cellular response to radiation (GO:0071478)4.98307993
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.71334615
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.52335952
26regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.51991558
27nucleobase catabolic process (GO:0046113)4.48204971
28adaptation of signaling pathway (GO:0023058)4.48170296
29behavioral response to nicotine (GO:0035095)4.32560245
30sensory perception (GO:0007600)4.19414420
31response to pheromone (GO:0019236)4.15829850
32regulation of cilium movement (GO:0003352)4.06989928
33regulation of penile erection (GO:0060405)4.02757939
34protein prenylation (GO:0018342)4.00372647
35prenylation (GO:0097354)4.00372647
36regulation of voltage-gated calcium channel activity (GO:1901385)3.99626911
37estrogen biosynthetic process (GO:0006703)3.96896724
38epithelial cilium movement (GO:0003351)3.94599901
39NADH dehydrogenase complex assembly (GO:0010257)3.88065937
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88065937
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.88065937
42response to light stimulus (GO:0009416)3.87503144
43protein complex biogenesis (GO:0070271)3.86528623
44ubiquinone biosynthetic process (GO:0006744)3.83338175
45protein polyglutamylation (GO:0018095)3.80464313
46neuron development (GO:0048666)3.72359358
47short-term memory (GO:0007614)3.69735655
48positive regulation of mitochondrial fission (GO:0090141)3.67874446
49behavioral response to ethanol (GO:0048149)3.65632285
50retina layer formation (GO:0010842)3.59773129
51positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.58364792
52retina homeostasis (GO:0001895)3.57919941
53regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.56889868
54regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.56889868
55neural tube formation (GO:0001841)3.55432458
56detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52532040
57mitochondrial respiratory chain complex assembly (GO:0033108)3.52188004
58ubiquinone metabolic process (GO:0006743)3.49331304
59platelet dense granule organization (GO:0060155)3.45325584
60cerebral cortex radially oriented cell migration (GO:0021799)3.31839755
61DNA deamination (GO:0045006)3.30438171
62replication fork processing (GO:0031297)3.28128597
63water-soluble vitamin biosynthetic process (GO:0042364)3.27903160
64response to histamine (GO:0034776)3.27082176
65chemosensory behavior (GO:0007635)3.22627087
66postsynaptic membrane organization (GO:0001941)3.20806997
67respiratory chain complex IV assembly (GO:0008535)3.19855013
68preassembly of GPI anchor in ER membrane (GO:0016254)3.18041841
69detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.17567816
70positive regulation of sodium ion transmembrane transport (GO:1902307)3.15426043
71peptidyl-histidine modification (GO:0018202)3.14483061
72positive regulation of neurotransmitter transport (GO:0051590)3.13539159
73quinone biosynthetic process (GO:1901663)3.13215260
74mannosylation (GO:0097502)3.12872690
75piRNA metabolic process (GO:0034587)3.12372150
76arginine catabolic process (GO:0006527)3.11845647
77positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.05999391
78positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03862752
79synaptic transmission, cholinergic (GO:0007271)3.01810829
80cilium movement (GO:0003341)3.01454064
81protein heterotetramerization (GO:0051290)3.01343344
82resolution of meiotic recombination intermediates (GO:0000712)3.01066365
83regulation of clathrin-mediated endocytosis (GO:2000369)2.99350743
84negative regulation of receptor-mediated endocytosis (GO:0048261)2.98224666
85regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.96990746
86tachykinin receptor signaling pathway (GO:0007217)2.95151333
87cornea development in camera-type eye (GO:0061303)2.94737042
88cytochrome complex assembly (GO:0017004)2.94426441
89detection of chemical stimulus involved in sensory perception (GO:0050907)2.93730283
90regulation of microtubule-based movement (GO:0060632)2.93021747
91protein localization to cilium (GO:0061512)2.91764271
92regulation of hexokinase activity (GO:1903299)2.90573893
93regulation of glucokinase activity (GO:0033131)2.90573893
94positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.90486849
95protein localization to synapse (GO:0035418)2.87058391
96negative regulation of telomere maintenance (GO:0032205)2.86478788
97cilium morphogenesis (GO:0060271)2.85553997
98fucose catabolic process (GO:0019317)2.83709476
99L-fucose metabolic process (GO:0042354)2.83709476
100L-fucose catabolic process (GO:0042355)2.83709476
101quinone metabolic process (GO:1901661)2.82637865
102negative regulation of transcription regulatory region DNA binding (GO:2000678)2.82457701
103establishment of mitochondrion localization (GO:0051654)2.80448884
104presynaptic membrane assembly (GO:0097105)2.79529355
105membrane hyperpolarization (GO:0060081)2.79062229
106nucleotide transmembrane transport (GO:1901679)2.78975314
107regulation of meiosis I (GO:0060631)2.77717562
108axoneme assembly (GO:0035082)2.75440972
109response to radiation (GO:0009314)2.74197421
110dopamine transport (GO:0015872)2.74148385
111retinoid metabolic process (GO:0001523)2.73862569
112peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.72388071
113retinol metabolic process (GO:0042572)2.72381931
114gamma-aminobutyric acid transport (GO:0015812)2.72345440
115anterograde synaptic vesicle transport (GO:0048490)2.70769474
116positive regulation of ERBB signaling pathway (GO:1901186)2.70721006
117cellular ketone body metabolic process (GO:0046950)2.68961178
118kidney morphogenesis (GO:0060993)2.65952307
119regulation of mitochondrial fission (GO:0090140)2.65350769
120arachidonic acid secretion (GO:0050482)2.64839531
121icosanoid secretion (GO:0032309)2.64839531
122S-adenosylmethionine metabolic process (GO:0046500)2.63440872
123synaptic transmission, dopaminergic (GO:0001963)2.61812336
124amine catabolic process (GO:0009310)2.60538412
125cellular biogenic amine catabolic process (GO:0042402)2.60538412
126neuron cell-cell adhesion (GO:0007158)2.59348786
127tRNA processing (GO:0008033)2.58002017
128negative regulation of cation channel activity (GO:2001258)2.57196729
129maturation of 5.8S rRNA (GO:0000460)2.57039633
130CDP-diacylglycerol biosynthetic process (GO:0016024)2.54875569
131ketone body metabolic process (GO:1902224)2.53977873
132aldehyde catabolic process (GO:0046185)2.53676153
133negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.53507357
134negative regulation of calcium ion transmembrane transport (GO:1903170)2.53507357
135behavioral response to cocaine (GO:0048148)2.52967177
136GPI anchor metabolic process (GO:0006505)2.52663118
137dopamine receptor signaling pathway (GO:0007212)2.52580268
138diterpenoid metabolic process (GO:0016101)2.51738107
139cellular response to abiotic stimulus (GO:0071214)2.50903321
140inositol phosphate catabolic process (GO:0071545)2.50133354
141regulation of action potential (GO:0098900)2.49511524
142positive regulation of cyclase activity (GO:0031281)2.49371511
143kynurenine metabolic process (GO:0070189)2.49093921
144branched-chain amino acid catabolic process (GO:0009083)2.48336021
145regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45722606
146DNA integration (GO:0015074)2.44016460
147short-chain fatty acid metabolic process (GO:0046459)2.43195240
148regulation of neurotransmitter uptake (GO:0051580)2.41503886
149peroxisome fission (GO:0016559)2.41221402
150regulation of feeding behavior (GO:0060259)2.40357711
151cilium organization (GO:0044782)2.39693381
152presynaptic membrane organization (GO:0097090)2.39187365
153regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38962933
154neurotransmitter catabolic process (GO:0042135)2.38605612
155positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.38221431
156negative regulation of mast cell activation (GO:0033004)2.36178769
157intraciliary transport (GO:0042073)2.35322806
158calcium ion-dependent exocytosis (GO:0017156)2.35289760
159C-terminal protein lipidation (GO:0006501)2.35225000
160cilium assembly (GO:0042384)2.35164089
161transcription elongation from RNA polymerase III promoter (GO:0006385)2.34505689
162termination of RNA polymerase III transcription (GO:0006386)2.34505689
163phospholipid translocation (GO:0045332)2.33990932
164lipid translocation (GO:0034204)2.33990932
165negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.32870745
166positive regulation of lyase activity (GO:0051349)2.32493875
167post-embryonic morphogenesis (GO:0009886)2.32136009
168CDP-diacylglycerol metabolic process (GO:0046341)2.30906121
169terpenoid metabolic process (GO:0006721)2.29656523
170regulation of catecholamine metabolic process (GO:0042069)2.28546396
171regulation of dopamine metabolic process (GO:0042053)2.28546396
172startle response (GO:0001964)2.23697565
173sensory perception of smell (GO:0007608)2.20603409
174regulation of rhodopsin mediated signaling pathway (GO:0022400)18.8049026
175rhodopsin mediated signaling pathway (GO:0016056)18.1780138
176retinal cone cell development (GO:0046549)16.1717162
177photoreceptor cell development (GO:0042461)12.3955023
178eye photoreceptor cell development (GO:0042462)11.9429138
179detection of light stimulus involved in sensory perception (GO:0050962)10.9665243
180detection of light stimulus involved in visual perception (GO:0050908)10.9665243
181* photoreceptor cell maintenance (GO:0045494)10.9601644
182phototransduction (GO:0007602)10.6666983
183phototransduction, visible light (GO:0007603)10.5113033
184positive regulation of guanylate cyclase activity (GO:0031284)10.4946937
185detection of light stimulus (GO:0009583)10.0996198
186detection of visible light (GO:0009584)10.0239102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.96470773
2ZNF274_21170338_ChIP-Seq_K562_Hela3.99454560
3VDR_22108803_ChIP-Seq_LS180_Human3.78707118
4CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.75191491
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.66478802
6GBX2_23144817_ChIP-Seq_PC3_Human3.42017841
7EZH2_22144423_ChIP-Seq_EOC_Human3.23272397
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60052447
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.48605425
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29771006
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.26054224
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18966181
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15726689
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12897479
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12839652
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10706153
17DROSHA_22980978_ChIP-Seq_HELA_Human2.01623342
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00928197
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95660457
20CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83414860
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.82881437
22IGF1R_20145208_ChIP-Seq_DFB_Human1.77100059
23FUS_26573619_Chip-Seq_HEK293_Human1.73860478
24EWS_26573619_Chip-Seq_HEK293_Human1.73325629
25IRF1_19129219_ChIP-ChIP_H3396_Human1.68543490
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67715989
27CBP_20019798_ChIP-Seq_JUKART_Human1.67715989
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67600684
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67446645
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66488304
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66304937
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65763113
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.61788397
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59864316
35SMAD3_21741376_ChIP-Seq_HESCs_Human1.58038519
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56701931
37AR_21572438_ChIP-Seq_LNCaP_Human1.56176786
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54279178
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53785525
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50255775
41TP53_22573176_ChIP-Seq_HFKS_Human1.49992567
42P300_19829295_ChIP-Seq_ESCs_Human1.48691947
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48271262
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.47832675
45SMAD4_21799915_ChIP-Seq_A2780_Human1.47323899
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47311666
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43911047
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.41472929
49TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40340964
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.39165046
51AR_19668381_ChIP-Seq_PC3_Human1.37880591
52* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37456258
53ELK1_19687146_ChIP-ChIP_HELA_Human1.37230151
54REST_21632747_ChIP-Seq_MESCs_Mouse1.34799030
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.34620119
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34469678
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34131315
58TAF15_26573619_Chip-Seq_HEK293_Human1.33303894
59VDR_23849224_ChIP-Seq_CD4+_Human1.32543186
60STAT3_23295773_ChIP-Seq_U87_Human1.32067293
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.31960306
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31959444
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31805582
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.31773635
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.31126491
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.30110660
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29675975
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29330719
69NANOG_19829295_ChIP-Seq_ESCs_Human1.29144312
70SOX2_19829295_ChIP-Seq_ESCs_Human1.29144312
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28669524
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27772329
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27772329
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.27187611
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.26580593
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.26355154
77NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.25877647
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25262362
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25104147
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25041400
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.24257907
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23836745
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23584268
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23553897
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22167380
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21798827
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21208340
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.21098242
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19826117
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.18906381
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18906381
92BCAT_22108803_ChIP-Seq_LS180_Human1.18879046
93AR_25329375_ChIP-Seq_VCAP_Human1.18841701
94TBL1_22424771_ChIP-Seq_293T_Human1.18055472
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.17279443
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.16819130
97MYC_18940864_ChIP-ChIP_HL60_Human1.16024656
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15028665
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.11168217
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10956052
101TCF4_23295773_ChIP-Seq_U87_Human1.09522599
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09378001
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.09109357
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08678513
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.08651780
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08447144
107ER_23166858_ChIP-Seq_MCF-7_Human1.07366715
108TCF4_22108803_ChIP-Seq_LS180_Human1.06980099
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06822763
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06633704
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06546727
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.06470841
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06440306
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05841576
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05826929
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05826929
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05818118
118AR_20517297_ChIP-Seq_VCAP_Human1.05734925
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05242172
120FLI1_27457419_Chip-Seq_LIVER_Mouse1.05206638
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05200252
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03199428
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.02983283
124ERA_21632823_ChIP-Seq_H3396_Human1.02652500
125ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02514366
126MYC_19829295_ChIP-Seq_ESCs_Human1.02032411
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02021201
128FOXP3_21729870_ChIP-Seq_TREG_Human1.01878200
129JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01455966
130AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01431738
131LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01324202
132HTT_18923047_ChIP-ChIP_STHdh_Human1.00314937
133SMAD_19615063_ChIP-ChIP_OVARY_Human0.99483177
134RNF2_27304074_Chip-Seq_NSC_Mouse0.99205200
135GF1_26923725_Chip-Seq_HPCs_Mouse0.98283997
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98183672
137SOX2_18555785_Chip-Seq_ESCs_Mouse0.97225094
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96023620
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95729203
140TAF2_19829295_ChIP-Seq_ESCs_Human0.95591193
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94945228
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94510529
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.94456202
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.93988584
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.93897072
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93698347
147NCOR_22424771_ChIP-Seq_293T_Human0.93304663
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93146936
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.93140371
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92917392
151KDM2B_26808549_Chip-Seq_REH_Human0.92204111
152P300_18555785_Chip-Seq_ESCs_Mouse0.91975568
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.91323632
154P53_22387025_ChIP-Seq_ESCs_Mouse0.91208909
155RUNX2_22187159_ChIP-Seq_PCA_Human0.91207958
156PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91152373
157CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90911465
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.89768425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.86481636
2MP0005253_abnormal_eye_physiology6.97603269
3MP0006072_abnormal_retinal_apoptosis6.30090184
4MP0003950_abnormal_plasma_membrane4.04371939
5MP0005195_abnormal_posterior_eye3.88919437
6MP0003787_abnormal_imprinting3.62731855
7MP0001324_abnormal_eye_pigmentation3.55404713
8MP0005391_vision/eye_phenotype3.41206050
9MP0002638_abnormal_pupillary_reflex3.28572646
10MP0001986_abnormal_taste_sensitivity2.83113659
11MP0003195_calcinosis2.82708065
12MP0008877_abnormal_DNA_methylation2.81073975
13MP0002090_abnormal_vision2.76092453
14MP0005423_abnormal_somatic_nervous2.65746872
15MP0001529_abnormal_vocalization2.61979733
16MP0002837_dystrophic_cardiac_calcinosis2.53575560
17MP0002229_neurodegeneration2.50192249
18MP0001764_abnormal_homeostasis2.27030777
19MP0008875_abnormal_xenobiotic_pharmacok2.26295501
20MP0003011_delayed_dark_adaptation10.6207584
21MP0002752_abnormal_somatic_nervous1.95199890
22MP0000372_irregular_coat_pigmentation1.94084713
23MP0004133_heterotaxia1.81590714
24MP0008872_abnormal_physiological_respon1.74953907
25MP0003121_genomic_imprinting1.72092715
26MP0002736_abnormal_nociception_after1.70183925
27MP0006276_abnormal_autonomic_nervous1.66742838
28MP0002234_abnormal_pharynx_morphology1.66422406
29MP0001485_abnormal_pinna_reflex1.64874787
30MP0003122_maternal_imprinting1.60123818
31MP0004147_increased_porphyrin_level1.42502494
32MP0003283_abnormal_digestive_organ1.41965704
33MP0003252_abnormal_bile_duct1.40177426
34MP0006292_abnormal_olfactory_placode1.36940628
35MP0002882_abnormal_neuron_morphology1.35739590
36MP0008995_early_reproductive_senescence1.34471312
37MP0003186_abnormal_redox_activity1.31014778
38MP0004019_abnormal_vitamin_homeostasis1.28915258
39MP0005084_abnormal_gallbladder_morpholo1.26314627
40MP0001270_distended_abdomen1.26009576
41MP0002653_abnormal_ependyma_morphology1.23986795
42MP0001984_abnormal_olfaction1.21164857
43MP0001502_abnormal_circadian_rhythm1.20969591
44MP0002938_white_spotting1.18640998
45MP0002735_abnormal_chemical_nociception1.15418934
46MP0005410_abnormal_fertilization1.09404305
47MP0003718_maternal_effect1.08535264
48MP0001970_abnormal_pain_threshold1.08230001
49MP0005394_taste/olfaction_phenotype1.05919855
50MP0005499_abnormal_olfactory_system1.05919855
51MP0008789_abnormal_olfactory_epithelium1.04766937
52MP0002733_abnormal_thermal_nociception1.03102934
53MP0005197_abnormal_uvea_morphology1.02788377
54MP0006035_abnormal_mitochondrial_morpho1.02492992
55MP0002163_abnormal_gland_morphology1.01460765
56MP0004885_abnormal_endolymph1.00321853
57MP0002254_reproductive_system_inflammat0.95469686
58MP0003136_yellow_coat_color0.94143454
59MP0008775_abnormal_heart_ventricle0.94015329
60MP0006036_abnormal_mitochondrial_physio0.91535399
61MP0002127_abnormal_cardiovascular_syste0.87768390
62MP0002909_abnormal_adrenal_gland0.87330754
63MP0002332_abnormal_exercise_endurance0.87007398
64MP0003137_abnormal_impulse_conducting0.86943952
65MP0000427_abnormal_hair_cycle0.85759810
66MP0001486_abnormal_startle_reflex0.83479868
67MP0002095_abnormal_skin_pigmentation0.83236234
68MP0002822_catalepsy0.81665794
69MP0001919_abnormal_reproductive_system0.79388102
70MP0004233_abnormal_muscle_weight0.77821990
71MP0003634_abnormal_glial_cell0.75679724
72MP0005646_abnormal_pituitary_gland0.73990525
73MP0002751_abnormal_autonomic_nervous0.73551110
74MP0003698_abnormal_male_reproductive0.72860066
75MP0005389_reproductive_system_phenotype0.72674873
76MP0002069_abnormal_eating/drinking_beha0.71436811
77MP0005332_abnormal_amino_acid0.71284829
78MP0002272_abnormal_nervous_system0.70832777
79MP0001963_abnormal_hearing_physiology0.64637810
80MP0001286_abnormal_eye_development0.61989978
81MP0004782_abnormal_surfactant_physiolog0.57642288
82MP0004270_analgesia0.55268070
83MP0005187_abnormal_penis_morphology0.54109137
84MP0010386_abnormal_urinary_bladder0.51016815
85MP0002734_abnormal_mechanical_nocicepti0.48807940
86MP0000026_abnormal_inner_ear0.47652223
87MP0005376_homeostasis/metabolism_phenot0.45376224
88MP0003045_fibrosis0.44171651
89MP0002572_abnormal_emotion/affect_behav0.43625174
90MP0001905_abnormal_dopamine_level0.43262756
91MP0009046_muscle_twitch0.42991013
92MP0001188_hyperpigmentation0.42770844
93MP0002067_abnormal_sensory_capabilities0.42475694
94MP0000631_abnormal_neuroendocrine_gland0.41116506
95MP0002064_seizures0.40964062
96MP0002102_abnormal_ear_morphology0.40784624
97MP0004742_abnormal_vestibular_system0.39135057
98MP0000465_gastrointestinal_hemorrhage0.37464133
99MP0002063_abnormal_learning/memory/cond0.37079772
100MP0000569_abnormal_digit_pigmentation0.36616193
101MP0003880_abnormal_central_pattern0.36553026
102MP0008058_abnormal_DNA_repair0.36428534
103MP0004142_abnormal_muscle_tone0.34321845
104MP0005386_behavior/neurological_phenoty0.33165077
105MP0004924_abnormal_behavior0.33165077
106MP0003635_abnormal_synaptic_transmissio0.31971143
107MP0009745_abnormal_behavioral_response0.31681571
108MP0009780_abnormal_chondrocyte_physiolo0.30361117
109MP0004043_abnormal_pH_regulation0.29623527
110MP0004215_abnormal_myocardial_fiber0.29495029
111MP0005310_abnormal_salivary_gland0.28782756
112MP0005595_abnormal_vascular_smooth0.28746386
113MP0002928_abnormal_bile_duct0.27212797
114MP0001968_abnormal_touch/_nociception0.26333172
115MP0005620_abnormal_muscle_contractility0.25203351
116MP0004145_abnormal_muscle_electrophysio0.24107294
117MP0001177_atelectasis0.23937725
118MP0004085_abnormal_heartbeat0.23813509
119MP0008004_abnormal_stomach_pH0.22125958
120MP0005248_abnormal_Harderian_gland0.21935272
121MP0003943_abnormal_hepatobiliary_system0.20680044
122MP0002557_abnormal_social/conspecific_i0.20399376
123MP0000778_abnormal_nervous_system0.18473133
124MP0002152_abnormal_brain_morphology0.18400281
125MP0008569_lethality_at_weaning0.17679710
126MP0001661_extended_life_span0.17391217
127MP0003890_abnormal_embryonic-extraembry0.16711659
128MP0002876_abnormal_thyroid_physiology0.16065273
129MP0003646_muscle_fatigue0.16001662
130MP0004859_abnormal_synaptic_plasticity0.15634035
131MP0002066_abnormal_motor_capabilities/c0.15583817
132MP0002697_abnormal_eye_size0.15170572
133MP0010030_abnormal_orbit_morphology0.14259248
134MP0001915_intracranial_hemorrhage0.13675646
135MP0005193_abnormal_anterior_eye0.13595755
136MP0004811_abnormal_neuron_physiology0.13174600
137MP0002108_abnormal_muscle_morphology0.13104700
138MP0002184_abnormal_innervation0.12754475
139MP0005645_abnormal_hypothalamus_physiol0.12037110
140MP0001501_abnormal_sleep_pattern0.11638777
141MP0003638_abnormal_response/metabolism_0.11082454
142MP0003632_abnormal_nervous_system0.10188600
143MP0001293_anophthalmia0.10007756
144MP0009764_decreased_sensitivity_to0.09955134
145MP0003183_abnormal_peptide_metabolism0.09877105

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)9.55373573
2Chorioretinal atrophy (HP:0000533)8.76434241
3Dyschromatopsia (HP:0007641)8.39523874
4Attenuation of retinal blood vessels (HP:0007843)7.86437266
5Central scotoma (HP:0000603)7.84339120
6Pendular nystagmus (HP:0012043)7.51533417
7Abnormality of macular pigmentation (HP:0008002)7.46225637
8Scotoma (HP:0000575)7.07515765
9Abolished electroretinogram (ERG) (HP:0000550)6.40509188
10Decreased central vision (HP:0007663)6.15402504
11Photophobia (HP:0000613)5.85234980
12Type II diabetes mellitus (HP:0005978)5.80233335
13Vitreoretinal degeneration (HP:0000655)5.04479784
14Macular degeneration (HP:0000608)4.85301000
15Keratoconus (HP:0000563)4.85180375
16Increased corneal curvature (HP:0100692)4.85180375
17Cone-rod dystrophy (HP:0000548)4.61599212
18Retinitis pigmentosa (HP:0000510)4.58459470
19Choroideremia (HP:0001139)4.51989072
20Posterior subcapsular cataract (HP:0007787)4.38216152
21Severe visual impairment (HP:0001141)4.35231376
22Constricted visual fields (HP:0001133)4.28219652
23Decreased electroretinogram (ERG) amplitude (HP:0000654)3.59506788
24Abnormality of the renal cortex (HP:0011035)3.29128913
25Intestinal atresia (HP:0011100)3.21640590
26Progressive visual loss (HP:0000529)3.09794410
27Acute necrotizing encephalopathy (HP:0006965)2.98538233
28Type II lissencephaly (HP:0007260)2.95528176
29Renal cortical cysts (HP:0000803)2.88868040
30Retinal atrophy (HP:0001105)2.84390639
31Hepatocellular necrosis (HP:0001404)2.83587399
32Optic disc pallor (HP:0000543)2.78307599
33Acute encephalopathy (HP:0006846)2.75313945
34Lissencephaly (HP:0001339)2.75242129
35Congenital sensorineural hearing impairment (HP:0008527)2.74614946
36Hyperglycinemia (HP:0002154)2.73839759
37Congenital primary aphakia (HP:0007707)2.71864884
38Gait imbalance (HP:0002141)2.71758379
39Increased CSF lactate (HP:0002490)2.71737283
40Progressive macrocephaly (HP:0004481)2.71176903
41Mitochondrial inheritance (HP:0001427)2.69541454
42Subcapsular cataract (HP:0000523)2.66805172
43Progressive inability to walk (HP:0002505)2.66399923
44Abnormal mitochondria in muscle tissue (HP:0008316)2.65389572
45Wide nasal bridge (HP:0000431)2.60518870
46Hepatic necrosis (HP:0002605)2.53116147
47Inability to walk (HP:0002540)2.48147040
48Nephrogenic diabetes insipidus (HP:0009806)2.47173634
49Medial flaring of the eyebrow (HP:0010747)2.43171107
50Absent speech (HP:0001344)2.35123677
51Hyperglycinuria (HP:0003108)2.34769909
52Hyperventilation (HP:0002883)2.32289507
53Large for gestational age (HP:0001520)2.32040218
54Pachygyria (HP:0001302)2.31772925
55Pancreatic islet-cell hyperplasia (HP:0004510)2.31459138
56Abnormality of the labia minora (HP:0012880)2.25936607
57Thyroid-stimulating hormone excess (HP:0002925)2.25190004
58Abnormal drinking behavior (HP:0030082)2.19657725
59Polydipsia (HP:0001959)2.19657725
60Abnormal respiratory epithelium morphology (HP:0012253)2.14457115
61Abnormal respiratory motile cilium morphology (HP:0005938)2.14457115
62Hemiparesis (HP:0001269)2.12447306
63Retinal dysplasia (HP:0007973)2.12309254
64Increased serum lactate (HP:0002151)2.11747542
65Hypothermia (HP:0002045)2.07857132
66Poor coordination (HP:0002370)2.07509087
67Drooling (HP:0002307)2.06070916
68Abnormality of serine family amino acid metabolism (HP:0010894)2.06030935
69Abnormality of glycine metabolism (HP:0010895)2.06030935
70Cerebral edema (HP:0002181)2.04073459
71Abnormal biliary tract physiology (HP:0012439)2.03955172
72Bile duct proliferation (HP:0001408)2.03955172
73Limb hypertonia (HP:0002509)2.03836689
743-Methylglutaconic aciduria (HP:0003535)2.03281873
75Congenital stationary night blindness (HP:0007642)15.2621918
76Bony spicule pigmentary retinopathy (HP:0007737)11.8077170
77Absent rod-and cone-mediated responses on ERG (HP:0007688)10.3000108
78Abnormal rod and cone electroretinograms (HP:0008323)10.1685519
79Abnormality of the metopic suture (HP:0005556)1.99202981
80Broad-based gait (HP:0002136)1.97990416
81Polyphagia (HP:0002591)1.94391238
82Polymicrogyria (HP:0002126)1.93276371
83Narrow forehead (HP:0000341)1.90752319
84Tubular atrophy (HP:0000092)1.90628132
85Disproportionate short-trunk short stature (HP:0003521)1.89915141
86Supernumerary spleens (HP:0009799)1.89344560
87Renal Fanconi syndrome (HP:0001994)1.88666935
88Enlarged kidneys (HP:0000105)1.88209904
89Progressive microcephaly (HP:0000253)1.87805165
90Vaginal atresia (HP:0000148)1.86091959
91Lactic acidosis (HP:0003128)1.85047740
92True hermaphroditism (HP:0010459)1.83838688
93Occipital encephalocele (HP:0002085)1.83400482
94Gaze-evoked nystagmus (HP:0000640)1.82307065
95Excessive salivation (HP:0003781)1.81649834
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.80697512
97Amblyopia (HP:0000646)1.79269637
98Genital tract atresia (HP:0001827)1.78783604
99Male pseudohermaphroditism (HP:0000037)1.78383747
100Increased hepatocellular lipid droplets (HP:0006565)1.77913526
101Agitation (HP:0000713)1.77352079
102Polyuria (HP:0000103)1.75891454
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75854246
104Abnormal protein N-linked glycosylation (HP:0012347)1.75854246
105Abnormal protein glycosylation (HP:0012346)1.75854246
106Abnormal glycosylation (HP:0012345)1.75854246
107Adrenal hypoplasia (HP:0000835)1.74314176
108Lipid accumulation in hepatocytes (HP:0006561)1.73925420
109Asplenia (HP:0001746)1.73630448
110Optic atrophy (HP:0000648)1.69033172
111Aplasia/Hypoplasia of the lens (HP:0008063)1.58821747
112Pancreatic fibrosis (HP:0100732)1.51321844
113Hypoplasia of the fovea (HP:0007750)1.50169580
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.50169580
115Interstitial pulmonary disease (HP:0006530)1.45170495
116Horizontal nystagmus (HP:0000666)1.43874189
117Abnormality of the fovea (HP:0000493)1.42439287
118Polar cataract (HP:0010696)1.41296703
119Febrile seizures (HP:0002373)1.34628464
120Astigmatism (HP:0000483)1.32438703
121Severe Myopia (HP:0011003)1.25407534
122Epileptic encephalopathy (HP:0200134)1.25394606
123Pancreatic cysts (HP:0001737)1.20259353
124Broad foot (HP:0001769)1.19501230
125Cystic liver disease (HP:0006706)1.18034485
126Dysdiadochokinesis (HP:0002075)1.16569542
127Retinal detachment (HP:0000541)1.16169679
128Abnormality of midbrain morphology (HP:0002418)1.12553183
129Molar tooth sign on MRI (HP:0002419)1.12553183
130Specific learning disability (HP:0001328)1.08535608
131Left ventricular hypertrophy (HP:0001712)1.06285139
132Aplasia/Hypoplasia of the macula (HP:0008059)1.06115083
133Cerebellar dysplasia (HP:0007033)1.05974565
134Recurrent sinusitis (HP:0011108)1.03924810
135Chorioretinal coloboma (HP:0000567)1.03692698
136Decreased testicular size (HP:0008734)1.01638140
137Asthma (HP:0002099)0.98824885
138Chronic hepatic failure (HP:0100626)0.98791269
139Aplasia/Hypoplasia of the tongue (HP:0010295)0.94938441
140Abnormality of dental color (HP:0011073)0.92023728
141Aplasia/Hypoplasia affecting the retina (HP:0008061)0.91555079
142Nephronophthisis (HP:0000090)0.91318561
143Sclerocornea (HP:0000647)0.89564953
144Congenital hepatic fibrosis (HP:0002612)0.87093577
145Progressive cerebellar ataxia (HP:0002073)0.86145610
146Postaxial hand polydactyly (HP:0001162)0.85664634
147Abnormality of the renal medulla (HP:0100957)0.81730096
148Hypermetropia (HP:0000540)0.81219803
149Truncal ataxia (HP:0002078)0.80804987
150Osteomalacia (HP:0002749)0.79906894
151Anencephaly (HP:0002323)0.77484887
152Dental crowding (HP:0000678)0.77145633
153Short foot (HP:0001773)0.76486318
154Lymphopenia (HP:0001888)0.75526197
155Furrowed tongue (HP:0000221)0.75379715
156Postaxial foot polydactyly (HP:0001830)0.75368521
157Abnormality of the fingertips (HP:0001211)0.71221473
158Hypodontia (HP:0000668)0.71019223
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.69479930
160Abnormality of cells of the lymphoid lineage (HP:0012140)0.67681919
161Septo-optic dysplasia (HP:0100842)0.67057472
162Albinism (HP:0001022)0.65518043
163Nephrotic syndrome (HP:0000100)0.63760329
164Multicystic kidney dysplasia (HP:0000003)0.63299961
165Preaxial hand polydactyly (HP:0001177)0.63015403
166Hirsutism (HP:0001007)0.62871744
167Prolonged QT interval (HP:0001657)0.61451501
168Partial agenesis of the corpus callosum (HP:0001338)0.61302716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.75676749
2PBK7.23088910
3MAP4K24.75810183
4WNK33.93497263
5IRAK22.91625078
6PINK12.87232017
7ADRBK22.28529346
8INSRR2.20344044
9WNK41.96543374
10BCKDK1.95036973
11PRPF4B1.90572719
12TRIM281.89645418
13CCNB11.81295570
14DYRK21.80014442
15AKT31.75367864
16BCR1.68369041
17MAPK71.66693625
18TAOK31.63308425
19SGK21.58901518
20ADRBK11.58752357
21SGK2231.57702981
22SGK4941.57702981
23CASK1.50787082
24STK161.46774589
25PAK31.41374184
26MAPK121.28476315
27CAMK1G1.26163089
28SIK21.25519774
29CDK31.24022154
30EPHA41.23287777
31MAP3K71.23089137
32CSNK1G31.18967140
33SGK31.18612240
34CSNK1G21.18497422
35RPS6KA41.14655762
36CDK121.13015703
37STK391.12935379
38TLK11.12140512
39MARK11.11435744
40OXSR11.08894643
41CSNK1G11.06765945
42NEK61.06515520
43YES11.06002155
44CSNK1A1L1.01547373
45TIE11.00813954
46PRKCZ0.99400639
47LATS10.99026475
48HIPK20.98895602
49MKNK20.96985928
50PRKCH0.95961084
51NTRK20.95516258
52BRD40.93320576
53ZAK0.91768158
54MAP2K70.90541618
55FGFR20.88454942
56PNCK0.84004868
57PRKD30.80070852
58CSNK1D0.77608312
59DAPK20.77444949
60CAMK1D0.77338378
61VRK10.74016151
62STK380.73474640
63TTK0.73248183
64EIF2AK30.72599313
65LIMK10.72593325
66FRK0.72587569
67MAPK130.72207857
68TNK20.70526241
69NUAK10.68993123
70DYRK1A0.68555775
71MAP3K40.68434205
72BMPR1B0.65906234
73TNIK0.64500116
74MST40.64213523
75MINK10.63306368
76PRKAA10.62702618
77EPHA30.62152330
78PTK2B0.60694888
79PRKCB0.59247469
80VRK20.59198323
81EPHB20.59125120
82IRAK10.57539466
83SRPK10.56466684
84PRKACG0.56278563
85FES0.56216169
86CDK90.56070774
87EIF2AK10.55786412
88PRKAA20.55692642
89CAMKK20.55589228
90FLT30.54872908
91MYLK0.54422829
92ERBB30.54174350
93CHUK0.53593730
94SGK10.53260653
95MAP3K100.52520679
96CAMK2D0.52471141
97RPS6KB10.52208615
98PLK20.52166287
99WNK10.51270330
100ERBB20.49036848
101CAMK10.47487249
102PLK30.47371858
103CDK50.46502083
104CSNK1A10.46039099
105PRKD20.45648134
106RPS6KA30.45298552
107PRKCQ0.45256401
108BMPR20.44303652
109PHKG20.44115181
110PHKG10.44115181
111GRK70.43458547
112MUSK0.43039203
113SIK30.42841564
114DYRK30.42818171
115MAPK140.42705984
116ICK0.42645947
117CAMK2A0.42035243
118MAP3K140.41813575
119RPS6KA50.41787233
120GRK50.41552323
121KDR0.40870876
122GSK3B0.40316430
123CDK190.38232509
124TXK0.37746773
125PRKDC0.37404485
126PRKCG0.37119143
127PAK60.36989891
128NTRK30.36380352
129PRKACA0.36187976
130FER0.36095199
131MAP2K60.34881365
132PRKCA0.34299413
133CAMK40.33852954
134MAP3K130.33846208
135MKNK10.33540748
136PRKCI0.33430637
137ACVR1B0.32904187
138AKT20.32138042
139CHEK20.31794307
140PIK3CA0.31372867
141PKN10.30952171
142ATM0.30713892
143STK38L0.30696328
144JAK10.30273396
145MAPK90.30257452
146ROCK10.30021606
147TEC0.29471389
148EIF2AK20.29427104
149ATR0.28622445
150CAMKK10.28567713
151NEK20.28237382
152CDK10.27844542
153PRKCE0.27002156

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.05316107
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.89550637
3Butanoate metabolism_Homo sapiens_hsa006502.87375950
4Protein export_Homo sapiens_hsa030602.50811810
5Oxidative phosphorylation_Homo sapiens_hsa001902.46712603
6Propanoate metabolism_Homo sapiens_hsa006402.09654180
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07709367
8RNA polymerase_Homo sapiens_hsa030202.03688214
9Steroid biosynthesis_Homo sapiens_hsa001002.02876228
10Phototransduction_Homo sapiens_hsa0474416.2025957
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85538612
12Parkinsons disease_Homo sapiens_hsa050121.85260386
13Olfactory transduction_Homo sapiens_hsa047401.49029916
14Peroxisome_Homo sapiens_hsa041461.45137553
15Synaptic vesicle cycle_Homo sapiens_hsa047211.42414472
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37735633
17Regulation of autophagy_Homo sapiens_hsa041401.36046944
18Huntingtons disease_Homo sapiens_hsa050161.34597795
19Basal transcription factors_Homo sapiens_hsa030221.33189354
20Selenocompound metabolism_Homo sapiens_hsa004501.32487548
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.30855539
22Alzheimers disease_Homo sapiens_hsa050101.27328603
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26066737
24Tryptophan metabolism_Homo sapiens_hsa003801.24579309
25Nitrogen metabolism_Homo sapiens_hsa009101.22635058
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.19803595
27Fanconi anemia pathway_Homo sapiens_hsa034601.17858082
28Proteasome_Homo sapiens_hsa030501.14317938
29Fatty acid metabolism_Homo sapiens_hsa012121.08934306
30Non-homologous end-joining_Homo sapiens_hsa034501.07124054
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03701712
32GABAergic synapse_Homo sapiens_hsa047271.02188623
33One carbon pool by folate_Homo sapiens_hsa006700.99158445
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98188210
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97613668
36beta-Alanine metabolism_Homo sapiens_hsa004100.97581131
37Retinol metabolism_Homo sapiens_hsa008300.96424104
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94449572
39Fat digestion and absorption_Homo sapiens_hsa049750.94236201
40Chemical carcinogenesis_Homo sapiens_hsa052040.91155968
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90895330
42Arachidonic acid metabolism_Homo sapiens_hsa005900.90877671
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88362453
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87774586
45Metabolic pathways_Homo sapiens_hsa011000.84283097
46Homologous recombination_Homo sapiens_hsa034400.82359267
47Circadian rhythm_Homo sapiens_hsa047100.82240037
48Morphine addiction_Homo sapiens_hsa050320.80377980
49Fatty acid degradation_Homo sapiens_hsa000710.79015386
50Cholinergic synapse_Homo sapiens_hsa047250.78668777
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76983349
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76659280
53Circadian entrainment_Homo sapiens_hsa047130.70023065
54Base excision repair_Homo sapiens_hsa034100.68625212
55Serotonergic synapse_Homo sapiens_hsa047260.68257466
56Glutamatergic synapse_Homo sapiens_hsa047240.67069020
57ABC transporters_Homo sapiens_hsa020100.66940417
58Tyrosine metabolism_Homo sapiens_hsa003500.66858273
59Dopaminergic synapse_Homo sapiens_hsa047280.66533660
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63924082
61Glutathione metabolism_Homo sapiens_hsa004800.62071937
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61974384
63Pyrimidine metabolism_Homo sapiens_hsa002400.61589279
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.59934301
65N-Glycan biosynthesis_Homo sapiens_hsa005100.58368611
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56499365
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54628395
68Nucleotide excision repair_Homo sapiens_hsa034200.52830619
69Purine metabolism_Homo sapiens_hsa002300.51968475
70Arginine and proline metabolism_Homo sapiens_hsa003300.51678470
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49683076
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.49137562
73Folate biosynthesis_Homo sapiens_hsa007900.48478690
74Insulin secretion_Homo sapiens_hsa049110.48207139
75Nicotine addiction_Homo sapiens_hsa050330.47607427
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42547002
77Dorso-ventral axis formation_Homo sapiens_hsa043200.42199372
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.41743083
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38209018
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35127136
81Sulfur relay system_Homo sapiens_hsa041220.34873395
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34187732
83Fructose and mannose metabolism_Homo sapiens_hsa000510.33479676
84cAMP signaling pathway_Homo sapiens_hsa040240.32292324
85Fatty acid elongation_Homo sapiens_hsa000620.31412282
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30823753
87Inositol phosphate metabolism_Homo sapiens_hsa005620.30183414
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28086228
89Oxytocin signaling pathway_Homo sapiens_hsa049210.26697073
90Chemokine signaling pathway_Homo sapiens_hsa040620.26488374
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25136931
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23873907
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22483742
94Glycerolipid metabolism_Homo sapiens_hsa005610.21556649
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20392109
96Cocaine addiction_Homo sapiens_hsa050300.20350271
97Caffeine metabolism_Homo sapiens_hsa002320.20305624
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20015437
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19338893
100Dilated cardiomyopathy_Homo sapiens_hsa054140.19057113
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.19053888
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18666451
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18613362
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.17205951
105Lysine degradation_Homo sapiens_hsa003100.17027215
106Renin secretion_Homo sapiens_hsa049240.16968472
107Salivary secretion_Homo sapiens_hsa049700.16641394
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16311035
109Collecting duct acid secretion_Homo sapiens_hsa049660.16035916
110Taste transduction_Homo sapiens_hsa047420.16013878
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.15884222
112Alcoholism_Homo sapiens_hsa050340.15737314
113mRNA surveillance pathway_Homo sapiens_hsa030150.15371532
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14592724
115Vitamin digestion and absorption_Homo sapiens_hsa049770.14425234
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14183740
117Galactose metabolism_Homo sapiens_hsa000520.13750708
118Type II diabetes mellitus_Homo sapiens_hsa049300.12544826
119Ras signaling pathway_Homo sapiens_hsa040140.11565112
120Calcium signaling pathway_Homo sapiens_hsa040200.11034576
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10727830
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10331083
123mTOR signaling pathway_Homo sapiens_hsa041500.10094841
124Gastric acid secretion_Homo sapiens_hsa049710.09672270
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09360928
126Amphetamine addiction_Homo sapiens_hsa050310.09153845
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08549168
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08421156
129RNA degradation_Homo sapiens_hsa030180.08392222
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08272003
131Rheumatoid arthritis_Homo sapiens_hsa053230.08165529
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07994727
133Glucagon signaling pathway_Homo sapiens_hsa049220.07614272
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.07109999
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06814693
136Mineral absorption_Homo sapiens_hsa049780.06730380
137Long-term potentiation_Homo sapiens_hsa047200.06584112
138Fatty acid biosynthesis_Homo sapiens_hsa000610.06577357
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06530449
140MAPK signaling pathway_Homo sapiens_hsa040100.06038893
141Cardiac muscle contraction_Homo sapiens_hsa042600.05983789
142Notch signaling pathway_Homo sapiens_hsa043300.05702352
143Wnt signaling pathway_Homo sapiens_hsa043100.05178424
144HIF-1 signaling pathway_Homo sapiens_hsa040660.05116745
145Vitamin B6 metabolism_Homo sapiens_hsa007500.05092553
146AMPK signaling pathway_Homo sapiens_hsa041520.04860431
147Linoleic acid metabolism_Homo sapiens_hsa005910.04202351
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.04082653
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03826952
150Ether lipid metabolism_Homo sapiens_hsa005650.03658463
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.02635884
152Ovarian steroidogenesis_Homo sapiens_hsa049130.01951613
153Graft-versus-host disease_Homo sapiens_hsa053320.01655933
154Autoimmune thyroid disease_Homo sapiens_hsa053200.01464828
155Arginine biosynthesis_Homo sapiens_hsa002200.01063056
156Sphingolipid metabolism_Homo sapiens_hsa006000.00830992
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.00744458
158Pancreatic secretion_Homo sapiens_hsa049720.00555357

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