NXNL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein insertion into membrane (GO:0051205)9.56626591
2* sensory perception of chemical stimulus (GO:0007606)8.80661954
3detection of light stimulus involved in sensory perception (GO:0050962)8.51835293
4detection of light stimulus involved in visual perception (GO:0050908)8.51835293
5photoreceptor cell development (GO:0042461)8.44933160
6phototransduction (GO:0007602)8.06276727
7* photoreceptor cell maintenance (GO:0045494)8.00416430
8protein localization to cilium (GO:0061512)7.77927149
9phototransduction, visible light (GO:0007603)7.73588691
10eye photoreceptor cell development (GO:0042462)7.63618140
11detection of light stimulus (GO:0009583)7.58828298
12positive regulation of guanylate cyclase activity (GO:0031284)7.55830825
13detection of visible light (GO:0009584)7.27171683
14GMP metabolic process (GO:0046037)7.26485630
15regulation of guanylate cyclase activity (GO:0031282)6.85675286
16* visual perception (GO:0007601)6.21606252
17* sensory perception of light stimulus (GO:0050953)6.14149425
18retinal rod cell development (GO:0046548)6.10126909
19eye photoreceptor cell differentiation (GO:0001754)5.38124729
20photoreceptor cell differentiation (GO:0046530)5.38124729
21detection of external stimulus (GO:0009581)5.28711639
22retina development in camera-type eye (GO:0060041)5.22700912
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.21457828
24detection of abiotic stimulus (GO:0009582)5.17036408
25regulation of cilium movement (GO:0003352)5.12509515
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)5.09750552
27protein-chromophore linkage (GO:0018298)5.08087355
28regulation of female gonad development (GO:2000194)5.06638036
29tryptophan catabolic process (GO:0006569)4.87700180
30indole-containing compound catabolic process (GO:0042436)4.87700180
31indolalkylamine catabolic process (GO:0046218)4.87700180
32indolalkylamine metabolic process (GO:0006586)4.85962561
33axoneme assembly (GO:0035082)4.78653909
34cellular response to light stimulus (GO:0071482)4.78221673
35regulation of voltage-gated calcium channel activity (GO:1901385)4.73110733
36regulation of cGMP metabolic process (GO:0030823)4.66110926
37nonmotile primary cilium assembly (GO:0035058)4.64900041
38regulation of chromatin binding (GO:0035561)4.56698651
39adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.55972423
40protein heterotetramerization (GO:0051290)4.55297087
41kynurenine metabolic process (GO:0070189)4.50200363
42protein K11-linked deubiquitination (GO:0035871)4.47728330
43behavioral response to cocaine (GO:0048148)4.39684370
44positive regulation of cGMP biosynthetic process (GO:0030828)4.39209214
45signal peptide processing (GO:0006465)4.31409198
46neural tube formation (GO:0001841)4.16267773
47cilium or flagellum-dependent cell motility (GO:0001539)4.15893484
48regulation of cGMP biosynthetic process (GO:0030826)4.13926474
49protein polyglutamylation (GO:0018095)4.12400174
50tryptophan metabolic process (GO:0006568)4.11718364
51dopamine receptor signaling pathway (GO:0007212)4.06915943
52fucose catabolic process (GO:0019317)4.03684949
53L-fucose metabolic process (GO:0042354)4.03684949
54L-fucose catabolic process (GO:0042355)4.03684949
55axonemal dynein complex assembly (GO:0070286)3.91000121
56regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.88831084
57regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.88831084
58cilium morphogenesis (GO:0060271)3.88509696
59* sensory perception (GO:0007600)3.87609472
60positive regulation of cGMP metabolic process (GO:0030825)3.85801850
61intraciliary transport (GO:0042073)3.84408202
62detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.72106959
63negative regulation of mast cell activation (GO:0033004)3.71392430
64retina homeostasis (GO:0001895)3.70670012
65negative regulation of cation channel activity (GO:2001258)3.66387198
66response to pheromone (GO:0019236)3.62984455
67microtubule severing (GO:0051013)3.62970092
68reflex (GO:0060004)3.62663597
69negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.60034338
70innate immune response in mucosa (GO:0002227)3.57144207
71monoubiquitinated protein deubiquitination (GO:0035520)3.56080899
72regulation of hippo signaling (GO:0035330)3.55991366
73regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.53447892
74melanosome transport (GO:0032402)3.53068183
75indole-containing compound metabolic process (GO:0042430)3.51057975
76auditory receptor cell differentiation (GO:0042491)3.50158849
77cellular ketone body metabolic process (GO:0046950)3.49306805
78receptor guanylyl cyclase signaling pathway (GO:0007168)3.41725749
79positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.41420622
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40917315
81establishment of protein localization to Golgi (GO:0072600)3.40089710
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36321088
83establishment of melanosome localization (GO:0032401)3.35939038
84regulation of sodium ion transmembrane transporter activity (GO:2000649)3.35609097
85auditory receptor cell stereocilium organization (GO:0060088)3.33967562
86pigment granule transport (GO:0051904)3.33459785
87behavioral response to nicotine (GO:0035095)3.32784206
88detection of mechanical stimulus involved in sensory perception (GO:0050974)3.31976137
89cell morphogenesis involved in neuron differentiation (GO:0048667)3.31281736
90amine catabolic process (GO:0009310)3.30821029
91cellular biogenic amine catabolic process (GO:0042402)3.30821029
92motile cilium assembly (GO:0044458)3.30186652
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30183896
94negative regulation of transcription regulatory region DNA binding (GO:2000678)3.29149081
95cellular response to electrical stimulus (GO:0071257)3.26511538
96antibacterial humoral response (GO:0019731)3.26464690
97regulation of sarcomere organization (GO:0060297)3.24610495
98negative regulation of calcium ion transmembrane transport (GO:1903170)3.23406460
99negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.23406460
100negative regulation of complement activation (GO:0045916)3.20370144
101tachykinin receptor signaling pathway (GO:0007217)3.18305849
102establishment of pigment granule localization (GO:0051905)3.18000529
103ketone body metabolic process (GO:1902224)3.17634808
104regulation of microtubule-based movement (GO:0060632)3.16420786
105positive regulation of neurotransmitter transport (GO:0051590)3.14838446
106sensory perception of taste (GO:0050909)3.14614379
107benzene-containing compound metabolic process (GO:0042537)3.10945520
108melanosome localization (GO:0032400)3.09230046
109DNA double-strand break processing (GO:0000729)3.06548740
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05918276
111piRNA metabolic process (GO:0034587)3.03748404
112behavioral response to ethanol (GO:0048149)3.03638620
113detection of calcium ion (GO:0005513)3.02913297
114proline transport (GO:0015824)3.01077359
115positive regulation of cyclase activity (GO:0031281)3.00907639
116gamma-aminobutyric acid transport (GO:0015812)2.99905898
117serotonin metabolic process (GO:0042428)2.99865045
118antimicrobial humoral response (GO:0019730)2.97548319
119pigment granule localization (GO:0051875)2.93899287
120positive regulation of developmental pigmentation (GO:0048087)2.92264766
121phosphorelay signal transduction system (GO:0000160)2.91925484
122cellular response to radiation (GO:0071478)2.91495250
123olfactory bulb development (GO:0021772)2.91352780
124synaptic transmission, dopaminergic (GO:0001963)2.90195444
125inner ear receptor stereocilium organization (GO:0060122)2.89890069
126mucosal immune response (GO:0002385)2.89722017
127hair cell differentiation (GO:0035315)2.89517803
128regulation of neurotransmitter uptake (GO:0051580)2.88143501
129regulation of cell communication by electrical coupling (GO:0010649)2.87018802
130snRNA transcription (GO:0009301)2.86601785
131cellular potassium ion transport (GO:0071804)2.85805649
132potassium ion transmembrane transport (GO:0071805)2.85805649
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84914417
134response to light stimulus (GO:0009416)2.84380387
135thyroid hormone metabolic process (GO:0042403)2.83676930
136primary amino compound metabolic process (GO:1901160)2.83105635
137negative regulation of calcium ion transport into cytosol (GO:0010523)2.82105075
138NAD biosynthetic process (GO:0009435)2.82015695
139cellular response to leptin stimulus (GO:0044320)2.81302809
140aromatic amino acid family catabolic process (GO:0009074)2.81110879
141regulation of sodium ion transmembrane transport (GO:1902305)2.81046291
142cellular response to sterol (GO:0036315)2.80251995
143reciprocal meiotic recombination (GO:0007131)2.78736957
144reciprocal DNA recombination (GO:0035825)2.78736957
145protein K48-linked deubiquitination (GO:0071108)2.77529888
146righting reflex (GO:0060013)2.77139229
147UDP-N-acetylglucosamine metabolic process (GO:0006047)2.76245387
148replication fork processing (GO:0031297)2.75846182
149oxidative demethylation (GO:0070989)2.74650257
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73108685
151aromatic amino acid family metabolic process (GO:0009072)2.71420641
152cilium organization (GO:0044782)2.70937946
153double-strand break repair via homologous recombination (GO:0000724)2.69616815
154recombinational repair (GO:0000725)2.68773659
155dopamine transport (GO:0015872)2.68585306
156cilium movement (GO:0003341)2.67506591
157multicellular organism reproduction (GO:0032504)2.66048385
158cilium assembly (GO:0042384)2.65956046
159neuronal action potential (GO:0019228)2.65079181
160epithelial cilium movement (GO:0003351)2.64269103
161regulation of action potential (GO:0098900)2.62939876
162regulation of acrosome reaction (GO:0060046)2.62890029
163sphingoid metabolic process (GO:0046519)2.62245328
164regulation of pigment cell differentiation (GO:0050932)2.61389859
165DNA methylation involved in gamete generation (GO:0043046)2.59561651
166sulfation (GO:0051923)2.59241527
167neuronal action potential propagation (GO:0019227)2.58279931
168prenylation (GO:0097354)2.57588292
169protein prenylation (GO:0018342)2.57588292
170startle response (GO:0001964)2.56489274
171protein K63-linked deubiquitination (GO:0070536)2.54964136
172adaptation of signaling pathway (GO:0023058)2.54076862
173central nervous system neuron axonogenesis (GO:0021955)2.53465023
174phosphatidylinositol acyl-chain remodeling (GO:0036149)2.52563108
175C4-dicarboxylate transport (GO:0015740)2.51911354
176regulation of posttranscriptional gene silencing (GO:0060147)2.50000705
177regulation of gene silencing by miRNA (GO:0060964)2.50000705
178regulation of gene silencing by RNA (GO:0060966)2.50000705
179flavonoid metabolic process (GO:0009812)2.48907724
180regulation of meiosis I (GO:0060631)2.48460788
181amino acid salvage (GO:0043102)2.46874233
182L-methionine salvage (GO:0071267)2.46874233
183L-methionine biosynthetic process (GO:0071265)2.46874233
184regulation of establishment of cell polarity (GO:2000114)2.45783543
185* sensory perception of smell (GO:0007608)14.2001331
186regulation of rhodopsin mediated signaling pathway (GO:0022400)12.6498411
187rhodopsin mediated signaling pathway (GO:0016056)11.9800034
188retinal cone cell development (GO:0046549)10.5633145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66770995
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.78596063
3ZNF274_21170338_ChIP-Seq_K562_Hela3.04660108
4ZNF263_19887448_ChIP-Seq_K562_Human2.96872015
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81934973
6VDR_22108803_ChIP-Seq_LS180_Human2.70449328
7GBX2_23144817_ChIP-Seq_PC3_Human2.66571387
8DROSHA_22980978_ChIP-Seq_HELA_Human2.60837863
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.50382787
10BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.45157082
11CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.45146982
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39565713
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.34585287
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.26606254
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.20953257
16FUS_26573619_Chip-Seq_HEK293_Human2.09815914
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09811952
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07911627
19EWS_26573619_Chip-Seq_HEK293_Human2.05408611
20ER_23166858_ChIP-Seq_MCF-7_Human1.97651323
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96188705
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93331764
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93085512
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90310617
25* STAT3_23295773_ChIP-Seq_U87_Human1.87312089
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.85912011
27KDM2B_26808549_Chip-Seq_K562_Human1.82258404
28BCAT_22108803_ChIP-Seq_LS180_Human1.78688857
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77708839
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76927914
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76927914
32REST_21632747_ChIP-Seq_MESCs_Mouse1.74775535
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74703402
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70957863
35CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69902340
36TCF4_23295773_ChIP-Seq_U87_Human1.69388197
37CBP_20019798_ChIP-Seq_JUKART_Human1.63318261
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63318261
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61837600
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.60754415
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55611179
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55340330
43AR_25329375_ChIP-Seq_VCAP_Human1.54597085
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53623151
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53566882
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.51195172
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.50682799
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50105964
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50105964
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.49940324
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48043536
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48006801
53LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46170440
54TCF4_22108803_ChIP-Seq_LS180_Human1.46148389
55NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.44298791
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43893267
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43630138
58RNF2_27304074_Chip-Seq_NSC_Mouse1.43547574
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42180903
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41030149
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.40962952
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39554124
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.39301284
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.39167181
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38193266
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36874243
67AR_21572438_ChIP-Seq_LNCaP_Human1.36588415
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34774142
69NANOG_19829295_ChIP-Seq_ESCs_Human1.34523241
70SOX2_19829295_ChIP-Seq_ESCs_Human1.34523241
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34410372
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34296525
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33546802
74RUNX2_22187159_ChIP-Seq_PCA_Human1.33358918
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32294662
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32210356
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31959760
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31548725
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.31168523
80TP53_22573176_ChIP-Seq_HFKS_Human1.31043258
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30740611
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30699305
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.30486022
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29588593
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29072863
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.28844971
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28157810
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26344279
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26107152
90NCOR_22424771_ChIP-Seq_293T_Human1.26064276
91IRF1_19129219_ChIP-ChIP_H3396_Human1.25734392
92* CDX2_22108803_ChIP-Seq_LS180_Human1.25422847
93TP53_16413492_ChIP-PET_HCT116_Human1.25139944
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25115667
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.24882266
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.24709401
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23994796
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.23538983
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.23511542
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23166810
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.23148809
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22961798
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20545793
104OCT4_20526341_ChIP-Seq_ESCs_Human1.19905174
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19626933
106TAF2_19829295_ChIP-Seq_ESCs_Human1.18298132
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17921202
108P53_22387025_ChIP-Seq_ESCs_Mouse1.15719923
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14911917
110CTCF_20526341_ChIP-Seq_ESCs_Human1.13971242
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13309170
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.13189508
113REST_18959480_ChIP-ChIP_MESCs_Mouse1.13143332
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12476737
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12419684
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.11948288
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11891847
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10600527
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09730033
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09121881
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.08904607
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07753570
123FOXA1_25329375_ChIP-Seq_VCAP_Human1.07387138
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07387138
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07054928
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06379346
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.06316895
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06296148
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06287864
130AHR_22903824_ChIP-Seq_MCF-7_Human1.06237868
131SMAD4_21799915_ChIP-Seq_A2780_Human1.06131689
132KDM2B_26808549_Chip-Seq_REH_Human1.06076811
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04944472
134NANOG_20526341_ChIP-Seq_ESCs_Human1.04857208
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04548741
136P300_18555785_Chip-Seq_ESCs_Mouse1.04224027
137SMC4_20622854_ChIP-Seq_HELA_Human1.04041220
138EZH2_27304074_Chip-Seq_ESCs_Mouse1.03857819
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.03077394
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02556574
141P300_19829295_ChIP-Seq_ESCs_Human1.01933706
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99530650
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99529211
144E2F1_20622854_ChIP-Seq_HELA_Human0.99281342
145IGF1R_20145208_ChIP-Seq_DFB_Human0.98704650
146JUN_21703547_ChIP-Seq_K562_Human0.98162343
147TAL1_26923725_Chip-Seq_HPCs_Mouse0.97938868
148CREB1_26743006_Chip-Seq_LNCaP_Human0.96925990
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96504484
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.95531328
151RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95064832
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.94912564
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94001342
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.93646082
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92937947
156EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92778071
157CTCF_27219007_Chip-Seq_Bcells_Human0.91546262
158AR_19668381_ChIP-Seq_PC3_Human0.89805210
159* LXR_22292898_ChIP-Seq_THP-1_Human0.89387124
160ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87979471
161STAT1_17558387_ChIP-Seq_HELA_Human0.87907677
162* SMAD4_21741376_ChIP-Seq_EPCs_Human0.87332770
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87047486
164YY1_22570637_ChIP-Seq_MALME-3M_Human0.86987178
165TAF15_26573619_Chip-Seq_HEK293_Human0.86029357
166GF1_26923725_Chip-Seq_HPCs_Mouse0.85987701
167CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85675272
168SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85374675
169EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85312971
170POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85142837
171SMAD4_21741376_ChIP-Seq_HESCs_Human0.84711827
172P68_20966046_ChIP-Seq_HELA_Human0.84704321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.69919854
2MP0003011_delayed_dark_adaptation6.28123095
3MP0005253_abnormal_eye_physiology4.61975565
4MP0006072_abnormal_retinal_apoptosis4.32518467
5MP0008789_abnormal_olfactory_epithelium3.53182417
6MP0003195_calcinosis3.38059931
7MP0000569_abnormal_digit_pigmentation3.34415326
8MP0005195_abnormal_posterior_eye3.21966767
9MP0005394_taste/olfaction_phenotype3.14739017
10MP0005499_abnormal_olfactory_system3.14739017
11MP0001968_abnormal_touch/_nociception2.82596241
12MP0005423_abnormal_somatic_nervous2.72507964
13MP0008877_abnormal_DNA_methylation2.70219432
14MP0002736_abnormal_nociception_after2.60075044
15MP0001501_abnormal_sleep_pattern2.54639166
16MP0005391_vision/eye_phenotype2.46361458
17MP0002638_abnormal_pupillary_reflex2.37259008
18MP0002752_abnormal_somatic_nervous2.36607268
19MP0008057_abnormal_DNA_replication2.33208671
20MP0002102_abnormal_ear_morphology2.31409375
21MP0002229_neurodegeneration2.23083090
22MP0001324_abnormal_eye_pigmentation2.20031991
23MP0002653_abnormal_ependyma_morphology2.12337734
24MP0000427_abnormal_hair_cycle2.11150757
25MP0001986_abnormal_taste_sensitivity2.10206102
26MP0001984_abnormal_olfaction10.5029072
27MP0004043_abnormal_pH_regulation1.95962715
28MP0005645_abnormal_hypothalamus_physiol1.94694772
29MP0003136_yellow_coat_color1.92820687
30MP0002837_dystrophic_cardiac_calcinosis1.83088535
31MP0003787_abnormal_imprinting1.76562842
32MP0008872_abnormal_physiological_respon1.75915110
33MP0002184_abnormal_innervation1.68880516
34MP0006054_spinal_hemorrhage1.67166949
35MP0002090_abnormal_vision1.66132313
36MP0002882_abnormal_neuron_morphology1.64486026
37MP0002876_abnormal_thyroid_physiology1.55300836
38MP0005174_abnormal_tail_pigmentation1.52040846
39MP0002138_abnormal_hepatobiliary_system1.51237700
40MP0003950_abnormal_plasma_membrane1.48005121
41MP0003718_maternal_effect1.44010661
42MP0005670_abnormal_white_adipose1.43283158
43MP0000383_abnormal_hair_follicle1.40745041
44MP0005084_abnormal_gallbladder_morpholo1.37680173
45MP0003806_abnormal_nucleotide_metabolis1.36207907
46MP0002272_abnormal_nervous_system1.33582300
47MP0001764_abnormal_homeostasis1.33278231
48MP0005386_behavior/neurological_phenoty1.29896885
49MP0003880_abnormal_central_pattern1.28430554
50MP0002735_abnormal_chemical_nociception1.26184454
51MP0004142_abnormal_muscle_tone1.25056174
52MP0001485_abnormal_pinna_reflex1.24526088
53MP0002938_white_spotting1.23890689
54MP0001542_abnormal_bone_strength1.23321450
55MP0005377_hearing/vestibular/ear_phenot1.21301947
56MP0003878_abnormal_ear_physiology1.21301947
57MP0002160_abnormal_reproductive_system1.18927898
58MP0005187_abnormal_penis_morphology1.18920300
59MP0005085_abnormal_gallbladder_physiolo1.17976840
60MP0001486_abnormal_startle_reflex1.16091172
61MP0002928_abnormal_bile_duct1.11931201
62MP0001502_abnormal_circadian_rhythm1.10944607
63MP0002734_abnormal_mechanical_nocicepti1.10736874
64MP0005075_abnormal_melanosome_morpholog1.08755272
65MP0008875_abnormal_xenobiotic_pharmacok1.06612451
66MP0005171_absent_coat_pigmentation1.06501323
67MP0005167_abnormal_blood-brain_barrier1.06355409
68MP0002234_abnormal_pharynx_morphology1.04468659
69MP0002095_abnormal_skin_pigmentation1.03514455
70MP0002168_other_aberrant_phenotype1.03510921
71MP0002733_abnormal_thermal_nociception1.03060862
72MP0005395_other_phenotype1.01884355
73MP0000230_abnormal_systemic_arterial1.01018257
74MP0000371_diluted_coat_color0.95180992
75MP0005646_abnormal_pituitary_gland0.95127639
76MP0001529_abnormal_vocalization0.91467256
77MP0002557_abnormal_social/conspecific_i0.90909258
78MP0000538_abnormal_urinary_bladder0.90151633
79MP0003633_abnormal_nervous_system0.88148318
80MP0001293_anophthalmia0.86380817
81MP0002127_abnormal_cardiovascular_syste0.85613499
82MP0004270_analgesia0.85244078
83MP0005266_abnormal_metabolism0.84398554
84MP0005647_abnormal_sex_gland0.82364474
85MP0003634_abnormal_glial_cell0.82031439
86MP0001929_abnormal_gametogenesis0.81628399
87MP0002254_reproductive_system_inflammat0.80375750
88MP0010678_abnormal_skin_adnexa0.80238853
89MP0008775_abnormal_heart_ventricle0.79589001
90MP0004782_abnormal_surfactant_physiolog0.79449275
91MP0003635_abnormal_synaptic_transmissio0.78291783
92MP0009780_abnormal_chondrocyte_physiolo0.76848137
93MP0005197_abnormal_uvea_morphology0.76836781
94MP0004145_abnormal_muscle_electrophysio0.76155421
95MP0010234_abnormal_vibrissa_follicle0.75301243
96MP0001919_abnormal_reproductive_system0.73972548
97MP0003252_abnormal_bile_duct0.73464966
98MP0005410_abnormal_fertilization0.69474255
99MP0004811_abnormal_neuron_physiology0.68829191
100MP0001963_abnormal_hearing_physiology0.66677963
101MP0009333_abnormal_splenocyte_physiolog0.65275992
102MP0002332_abnormal_exercise_endurance0.64742504
103MP0004742_abnormal_vestibular_system0.64282991
104MP0002152_abnormal_brain_morphology0.64076408
105MP0000778_abnormal_nervous_system0.63554023
106MP0005367_renal/urinary_system_phenotyp0.61934857
107MP0000516_abnormal_urinary_system0.61934857
108MP0002233_abnormal_nose_morphology0.61406674
109MP0004019_abnormal_vitamin_homeostasis0.61038077
110MP0002063_abnormal_learning/memory/cond0.60572707
111MP0000631_abnormal_neuroendocrine_gland0.60087531
112MP0000003_abnormal_adipose_tissue0.58210667
113MP0001661_extended_life_span0.58046867
114MP0002572_abnormal_emotion/affect_behav0.57238577
115MP0002822_catalepsy0.55828247
116MP0000026_abnormal_inner_ear0.54376184
117MP0002067_abnormal_sensory_capabilities0.54348501
118MP0001286_abnormal_eye_development0.51330487
119MP0002064_seizures0.50010013
120MP0010386_abnormal_urinary_bladder0.45551379
121MP0000372_irregular_coat_pigmentation0.45230149
122MP0004233_abnormal_muscle_weight0.45016442
123MP0003646_muscle_fatigue0.44056440
124MP0005389_reproductive_system_phenotype0.40913033
125MP0004147_increased_porphyrin_level0.40838417
126MP0006276_abnormal_autonomic_nervous0.40756773
127MP0003861_abnormal_nervous_system0.40017585
128MP0005310_abnormal_salivary_gland0.39836175
129MP0004885_abnormal_endolymph0.39381669
130MP0002092_abnormal_eye_morphology0.38262205
131MP0001188_hyperpigmentation0.36891748
132MP0009046_muscle_twitch0.35515412
133MP0003879_abnormal_hair_cell0.35077853
134MP0004215_abnormal_myocardial_fiber0.34727469
135MP0009745_abnormal_behavioral_response0.34328551
136MP0005584_abnormal_enzyme/coenzyme_acti0.33728586
137MP0002877_abnormal_melanocyte_morpholog0.33165987
138MP0001970_abnormal_pain_threshold0.32278723
139MP0006292_abnormal_olfactory_placode0.32132820
140MP0005595_abnormal_vascular_smooth0.30018363
141MP0004085_abnormal_heartbeat0.29276182
142MP0002066_abnormal_motor_capabilities/c0.29172158
143MP0003045_fibrosis0.28928187
144MP0005193_abnormal_anterior_eye0.28757403
145MP0001905_abnormal_dopamine_level0.27496292
146MP0003698_abnormal_male_reproductive0.26776785
147MP0002909_abnormal_adrenal_gland0.26529477
148MP0004924_abnormal_behavior0.26420114

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.46525490
2Abnormal rod and cone electroretinograms (HP:0008323)8.97715205
3Abnormality of macular pigmentation (HP:0008002)8.49358103
4Pigmentary retinal degeneration (HP:0001146)7.57240534
5Central scotoma (HP:0000603)7.25338579
6Dyschromatopsia (HP:0007641)6.65289442
7Abolished electroretinogram (ERG) (HP:0000550)6.57486379
8Chorioretinal atrophy (HP:0000533)6.53288062
9Scotoma (HP:0000575)5.72088995
10Attenuation of retinal blood vessels (HP:0007843)5.60447778
11Pendular nystagmus (HP:0012043)5.54250615
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.09428923
13Type II diabetes mellitus (HP:0005978)5.05722995
14Decreased central vision (HP:0007663)4.93507868
15Photophobia (HP:0000613)4.77264025
16Posterior subcapsular cataract (HP:0007787)4.38761509
17Retinitis pigmentosa (HP:0000510)4.38662778
18Severe visual impairment (HP:0001141)4.28005427
19Hyperventilation (HP:0002883)4.16742896
20Constricted visual fields (HP:0001133)4.11099028
21Gaze-evoked nystagmus (HP:0000640)3.86365250
22Vitreoretinal degeneration (HP:0000655)3.83981541
23Gait imbalance (HP:0002141)3.75223579
24Congenital primary aphakia (HP:0007707)3.70258411
25Macular degeneration (HP:0000608)3.68296500
26Retinal dysplasia (HP:0007973)3.68279243
27Choroideremia (HP:0001139)3.64935358
28Cone-rod dystrophy (HP:0000548)3.61616634
29Nephrogenic diabetes insipidus (HP:0009806)3.37674883
30Medial flaring of the eyebrow (HP:0010747)3.32829032
31Keratoconus (HP:0000563)3.30562139
32Increased corneal curvature (HP:0100692)3.30562139
33Abnormality of the renal cortex (HP:0011035)3.30424376
34Abnormal respiratory motile cilium physiology (HP:0012261)3.26014859
35Genetic anticipation (HP:0003743)3.20123854
36Rhinitis (HP:0012384)3.00743172
37Progressive cerebellar ataxia (HP:0002073)2.95752107
38Type II lissencephaly (HP:0007260)2.90817331
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.89022095
40Poor coordination (HP:0002370)2.79508138
41Chronic bronchitis (HP:0004469)2.77701585
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.75883745
43Absent speech (HP:0001344)2.75640814
44Molar tooth sign on MRI (HP:0002419)2.73663214
45Abnormality of midbrain morphology (HP:0002418)2.73663214
46Subcapsular cataract (HP:0000523)2.71523789
47Vaginal atresia (HP:0000148)2.68082436
48Tubular atrophy (HP:0000092)2.62178402
49True hermaphroditism (HP:0010459)2.61932277
50Fair hair (HP:0002286)2.59545259
51Focal seizures (HP:0007359)2.57199882
52Abnormal respiratory epithelium morphology (HP:0012253)2.54999434
53Abnormal respiratory motile cilium morphology (HP:0005938)2.54999434
54Genital tract atresia (HP:0001827)2.54331306
55Inability to walk (HP:0002540)2.53323587
56Protruding tongue (HP:0010808)2.53035298
57Progressive inability to walk (HP:0002505)2.52677833
58Abnormal ciliary motility (HP:0012262)2.43942632
59Cerebellar dysplasia (HP:0007033)2.42753587
60Limb dystonia (HP:0002451)2.39658412
61Progressive visual loss (HP:0000529)2.35331486
62Aplasia/Hypoplasia of the lens (HP:0008063)2.33972267
63Renal cortical cysts (HP:0000803)2.33952850
64Stomach cancer (HP:0012126)2.32883774
65Anencephaly (HP:0002323)2.32501250
66Congenital hepatic fibrosis (HP:0002612)2.32347614
67Abnormal drinking behavior (HP:0030082)2.32019938
68Polydipsia (HP:0001959)2.32019938
69Lissencephaly (HP:0001339)2.29953051
70Clumsiness (HP:0002312)2.29040524
71Bifid tongue (HP:0010297)2.26405396
72Optic disc pallor (HP:0000543)2.24791636
73Dialeptic seizures (HP:0011146)2.24557591
74Febrile seizures (HP:0002373)2.24364633
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24058620
76Abnormality of alanine metabolism (HP:0010916)2.24058620
77Hyperalaninemia (HP:0003348)2.24058620
78Wide nasal bridge (HP:0000431)2.20064168
79Postaxial foot polydactyly (HP:0001830)2.18448263
80Bile duct proliferation (HP:0001408)2.18294607
81Abnormal biliary tract physiology (HP:0012439)2.18294607
82Focal motor seizures (HP:0011153)2.11240397
83Thyroid-stimulating hormone excess (HP:0002925)2.10226050
84Recurrent sinusitis (HP:0011108)2.10155082
85Small hand (HP:0200055)2.09743026
86Absent/shortened dynein arms (HP:0200106)2.07749686
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.07749686
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07467102
89Intestinal atresia (HP:0011100)2.06877833
90Generalized hypopigmentation of hair (HP:0011358)2.05516311
91Chronic hepatic failure (HP:0100626)2.05435026
92Tubulointerstitial nephritis (HP:0001970)2.03989229
93Decreased circulating renin level (HP:0003351)2.02026016
94Widely spaced teeth (HP:0000687)2.00710910
95Palpitations (HP:0001962)2.00518133
96Congenital stationary night blindness (HP:0007642)12.1791143
97Bony spicule pigmentary retinopathy (HP:0007737)10.6807131
98Pancreatic fibrosis (HP:0100732)1.99927802
99Dysphonia (HP:0001618)1.94263179
100Broad-based gait (HP:0002136)1.93957811
101Increased neuronal autofluorescent lipopigment (HP:0002074)1.92916355
102Male pseudohermaphroditism (HP:0000037)1.92623612
103Atonic seizures (HP:0010819)1.91734098
104Hemiparesis (HP:0001269)1.91024384
105Postaxial hand polydactyly (HP:0001162)1.90966216
106Hypoplasia of the fovea (HP:0007750)1.90958393
107Aplasia/Hypoplasia of the fovea (HP:0008060)1.90958393
108Large for gestational age (HP:0001520)1.90203373
109Tubulointerstitial abnormality (HP:0001969)1.87141750
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.86625665
111Sloping forehead (HP:0000340)1.86512769
112Cystic liver disease (HP:0006706)1.84133079
113Abnormality of dentin (HP:0010299)1.83912886
114Ketoacidosis (HP:0001993)1.82242047
115Polyuria (HP:0000103)1.82178107
116Preaxial hand polydactyly (HP:0001177)1.82067866
117Hypothermia (HP:0002045)1.81155817
118Volvulus (HP:0002580)1.80130232
119Oligodactyly (hands) (HP:0001180)1.80114046
120Short foot (HP:0001773)1.79905056
121Pancreatic cysts (HP:0001737)1.78302473
122Sclerocornea (HP:0000647)1.77775673
123Short nail (HP:0001799)1.76306312
124Hypoplastic ischia (HP:0003175)1.75626007
125Hypoplasia of the pons (HP:0012110)1.75323545
126Nephronophthisis (HP:0000090)1.74363242
127Specific learning disability (HP:0001328)1.73247140
128Syncope (HP:0001279)1.69775458
129Decreased testicular size (HP:0008734)1.68776507
130Optic atrophy (HP:0000648)1.65640902
131Hypochromic microcytic anemia (HP:0004840)1.64616424
132Anosmia (HP:0000458)1.63012680
133Left ventricular hypertrophy (HP:0001712)1.55240621
134Recurrent otitis media (HP:0000403)1.54468612
135Congenital sensorineural hearing impairment (HP:0008527)1.52478660
136Retinal atrophy (HP:0001105)1.50852641
137Bronchiectasis (HP:0002110)1.49617453
138Poikilocytosis (HP:0004447)1.49582305
139Restlessness (HP:0000711)1.46047073
140Broad foot (HP:0001769)1.45729811
141Furrowed tongue (HP:0000221)1.43307132
142Absence seizures (HP:0002121)1.40885856
143Occipital encephalocele (HP:0002085)1.39529200
144Polar cataract (HP:0010696)1.38166775
145Torticollis (HP:0000473)1.36590487
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.34536801
147Abnormality of the renal medulla (HP:0100957)1.28788495
148Myokymia (HP:0002411)1.27739920
149Prolonged QT interval (HP:0001657)1.26126374
150Diminished motivation (HP:0000745)1.25899654
151Asthma (HP:0002099)1.25768758
152Oculomotor apraxia (HP:0000657)1.24816140
153Agitation (HP:0000713)1.24604568
154Astigmatism (HP:0000483)1.23846212
155Craniofacial dystonia (HP:0012179)1.22497694
156Sex reversal (HP:0012245)1.22352737
157Abnormal sex determination (HP:0012244)1.22352737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.81494120
2PHKG24.81494120
3GRK14.41157525
4MAPK153.86253835
5ERBB33.49199683
6PAK33.30400990
7PBK3.01347979
8ICK2.84692115
9ACVR1B2.82937433
10ADRBK22.81630427
11BMPR1B2.69036315
12WNK32.55157334
13MAP4K22.28084217
14NUAK12.07087456
15ARAF2.05878802
16MAP3K102.04228160
17CAMK2D1.97863275
18FRK1.97268422
19ZAK1.92498202
20CCNB11.81300944
21STK38L1.76872883
22TAOK31.70750530
23EEF2K1.69176984
24MKNK21.65242494
25IRAK21.62732235
26MAPKAPK31.58183440
27CAMK1G1.53271503
28STK161.50965683
29OXSR11.50460835
30SIK21.49851270
31PIK3CG1.47115509
32STK381.46556618
33CAMK1D1.45636049
34CAMK2B1.40073728
35STK241.39773246
36TRIM281.38148484
37RPS6KA41.37467128
38CAMK2G1.24264614
39FER1.20201557
40DAPK21.18102381
41NTRK31.15129908
42HIPK21.14437427
43DYRK1A1.10719035
44CDK31.09813658
45INSRR1.09159280
46STK31.07616478
47EIF2AK31.04829708
48CAMKK21.04678784
49PRKCE1.04371156
50BRSK21.02652180
51PRKCG1.02002079
52DYRK31.01950436
53PRKD30.99976865
54TXK0.99390696
55PTK2B0.98118227
56MAPK70.97879212
57AKT30.97252830
58CSNK1A1L0.95184618
59TNK20.94641901
60BCR0.93764312
61PLK20.92479084
62TEC0.91381685
63SGK4940.90504960
64SGK2230.90504960
65EPHA40.88816288
66PIK3CA0.86849131
67MKNK10.85068641
68PRKCZ0.80133630
69GRK50.79816177
70PINK10.78319775
71STK110.78080299
72ADRBK10.76074828
73PAK60.75671806
74CSNK1G30.74943347
75MAPK120.74404426
76TGFBR10.74394956
77CDK90.70346993
78CAMK2A0.69606219
79MAP3K40.69560721
80TTK0.69316810
81MARK10.69235863
82NLK0.68338801
83RPS6KA20.68027470
84ILK0.64423917
85STK390.63571573
86PRKAA20.63204767
87PRKAA10.61989553
88PKN10.61915445
89MAP3K70.59986636
90MARK30.59590726
91CSNK1G20.59180599
92PIM20.57983703
93DAPK10.56981883
94AKT20.56368182
95CSNK1G10.56028778
96NEK20.55961352
97BRAF0.55146908
98PNCK0.54888852
99CAMKK10.54581139
100TIE10.54462180
101DYRK1B0.54436506
102PRKCI0.52957779
103ERBB20.51555141
104MUSK0.51000473
105MST40.49575387
106PRKACG0.48322650
107SIK30.47807629
108TLK10.47346685
109MAPK130.47293221
110WNK40.45487320
111TRPM70.45284006
112PRKD20.44954535
113IKBKB0.44786735
114CASK0.43917817
115PDK20.43504520
116RPS6KB20.42941407
117OBSCN0.42489255
118TNIK0.42265028
119PRKCQ0.39341849
120KIT0.38710589
121MELK0.37593790
122CSNK1D0.37242503
123GRK60.36382495
124NTRK20.36164945
125MAP2K70.35204489
126PLK40.34685096
127FLT30.33917453
128LATS10.33382100
129PRKCB0.33224199
130CHUK0.32406294
131CAMK40.31110580
132MINK10.31045243
133MAPKAPK50.31002092
134PRKG10.30528726
135WNK10.30506378
136PLK10.30384286
137SGK20.30140486
138BMPR20.29997148
139CDK190.29990656
140CSNK1A10.29739958
141MYLK0.29457603
142PRKCA0.29303723
143ATM0.28820822
144PRKACB0.28660811
145PRKACA0.28351272
146RPS6KA50.27600930
147PRKCH0.26104278
148CAMK10.23296927
149BRD40.22155304
150CDK50.21893956
151FGFR20.21625678
152MAPK90.21171722
153CDK70.20775259
154PLK30.20338337
155IRAK10.20131223

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047407.52567809
2Butanoate metabolism_Homo sapiens_hsa006503.02080311
3Tryptophan metabolism_Homo sapiens_hsa003802.47109063
4Linoleic acid metabolism_Homo sapiens_hsa005912.43596313
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28046713
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23757717
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23738832
8Nitrogen metabolism_Homo sapiens_hsa009102.09998409
9Propanoate metabolism_Homo sapiens_hsa006402.09357993
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.04702873
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04230268
12Phototransduction_Homo sapiens_hsa0474412.9996799
13Homologous recombination_Homo sapiens_hsa034401.94461295
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92233939
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.82810705
16Ether lipid metabolism_Homo sapiens_hsa005651.77491610
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62206535
18Fanconi anemia pathway_Homo sapiens_hsa034601.60670157
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59994715
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58836055
21Selenocompound metabolism_Homo sapiens_hsa004501.47943840
22Synaptic vesicle cycle_Homo sapiens_hsa047211.46398831
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42437712
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35364455
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.34879110
26GABAergic synapse_Homo sapiens_hsa047271.34125698
27Chemical carcinogenesis_Homo sapiens_hsa052041.33060605
28Circadian entrainment_Homo sapiens_hsa047131.32779735
29Caffeine metabolism_Homo sapiens_hsa002321.29098856
30Dopaminergic synapse_Homo sapiens_hsa047281.27541562
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24176046
32Morphine addiction_Homo sapiens_hsa050321.22887323
33Glycerolipid metabolism_Homo sapiens_hsa005611.21915009
34Basal transcription factors_Homo sapiens_hsa030221.21178467
35Cholinergic synapse_Homo sapiens_hsa047251.14968669
36Arachidonic acid metabolism_Homo sapiens_hsa005901.14545520
37Dorso-ventral axis formation_Homo sapiens_hsa043201.06102035
38Insulin secretion_Homo sapiens_hsa049111.04967341
39Non-homologous end-joining_Homo sapiens_hsa034501.04919583
40Taste transduction_Homo sapiens_hsa047421.04790043
41Glutamatergic synapse_Homo sapiens_hsa047241.01769819
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01534752
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01019891
44cAMP signaling pathway_Homo sapiens_hsa040241.00959931
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00871641
46Fatty acid degradation_Homo sapiens_hsa000710.96557499
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96247027
48Peroxisome_Homo sapiens_hsa041460.93227220
49One carbon pool by folate_Homo sapiens_hsa006700.87159871
50Protein export_Homo sapiens_hsa030600.85767393
51Alcoholism_Homo sapiens_hsa050340.84954285
52Lysine degradation_Homo sapiens_hsa003100.84903247
53RNA polymerase_Homo sapiens_hsa030200.78300598
54Gastric acid secretion_Homo sapiens_hsa049710.76054916
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75254384
56Fatty acid metabolism_Homo sapiens_hsa012120.74922017
57Ovarian steroidogenesis_Homo sapiens_hsa049130.74419088
58Salivary secretion_Homo sapiens_hsa049700.73515781
59Regulation of autophagy_Homo sapiens_hsa041400.73169993
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71884102
61Long-term depression_Homo sapiens_hsa047300.71664959
62Purine metabolism_Homo sapiens_hsa002300.65519515
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65362925
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.65104582
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65092330
66Amphetamine addiction_Homo sapiens_hsa050310.62393121
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62203430
68RNA degradation_Homo sapiens_hsa030180.61417777
69Vibrio cholerae infection_Homo sapiens_hsa051100.60877887
70Serotonergic synapse_Homo sapiens_hsa047260.60719218
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59375615
72Glucagon signaling pathway_Homo sapiens_hsa049220.57631410
73Renin secretion_Homo sapiens_hsa049240.57580441
74Calcium signaling pathway_Homo sapiens_hsa040200.55747763
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55501621
76ABC transporters_Homo sapiens_hsa020100.54963896
77Bile secretion_Homo sapiens_hsa049760.54228576
78Oxytocin signaling pathway_Homo sapiens_hsa049210.53927901
79Long-term potentiation_Homo sapiens_hsa047200.52003092
80GnRH signaling pathway_Homo sapiens_hsa049120.51375571
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50593552
82Cardiac muscle contraction_Homo sapiens_hsa042600.49572224
83Metabolic pathways_Homo sapiens_hsa011000.47962174
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44628852
85Fat digestion and absorption_Homo sapiens_hsa049750.44229907
86Fatty acid biosynthesis_Homo sapiens_hsa000610.43645138
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42996635
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42993563
89Retinol metabolism_Homo sapiens_hsa008300.42536590
90N-Glycan biosynthesis_Homo sapiens_hsa005100.41852087
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40788978
92Parkinsons disease_Homo sapiens_hsa050120.39797154
93Melanogenesis_Homo sapiens_hsa049160.39394645
94Circadian rhythm_Homo sapiens_hsa047100.38894296
95Thyroid hormone synthesis_Homo sapiens_hsa049180.38741556
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38499568
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38441609
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.35087378
99Dilated cardiomyopathy_Homo sapiens_hsa054140.35032483
100Estrogen signaling pathway_Homo sapiens_hsa049150.34792810
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33230024
102Mineral absorption_Homo sapiens_hsa049780.33226329
103Asthma_Homo sapiens_hsa053100.32509797
104Pancreatic secretion_Homo sapiens_hsa049720.31340068
105Insulin signaling pathway_Homo sapiens_hsa049100.31177096
106Ras signaling pathway_Homo sapiens_hsa040140.30940327
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30892808
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30843446
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29745530
110Oocyte meiosis_Homo sapiens_hsa041140.29474733
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29267535
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.28961243
113Nicotine addiction_Homo sapiens_hsa050330.28593598
114Sphingolipid metabolism_Homo sapiens_hsa006000.28108814
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27611977
116Systemic lupus erythematosus_Homo sapiens_hsa053220.27082922
117mTOR signaling pathway_Homo sapiens_hsa041500.26812934
118Alzheimers disease_Homo sapiens_hsa050100.26731797
119Cocaine addiction_Homo sapiens_hsa050300.25511134
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24843561
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22922987
122Gap junction_Homo sapiens_hsa045400.21655603
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21152387
124Chemokine signaling pathway_Homo sapiens_hsa040620.21075727
125Glioma_Homo sapiens_hsa052140.20310947
126Collecting duct acid secretion_Homo sapiens_hsa049660.20236877
127Platelet activation_Homo sapiens_hsa046110.20133316
128Histidine metabolism_Homo sapiens_hsa003400.19558230
129AMPK signaling pathway_Homo sapiens_hsa041520.19542394
130Pyruvate metabolism_Homo sapiens_hsa006200.19318170
131Sulfur metabolism_Homo sapiens_hsa009200.19224004
132TGF-beta signaling pathway_Homo sapiens_hsa043500.19193785
133Oxidative phosphorylation_Homo sapiens_hsa001900.19006048
134Melanoma_Homo sapiens_hsa052180.18498494
135PPAR signaling pathway_Homo sapiens_hsa033200.18195654
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17439389
137beta-Alanine metabolism_Homo sapiens_hsa004100.15907028
138Huntingtons disease_Homo sapiens_hsa050160.14697666
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14176642
140Vitamin digestion and absorption_Homo sapiens_hsa049770.13097622
141Axon guidance_Homo sapiens_hsa043600.12753345
142Rap1 signaling pathway_Homo sapiens_hsa040150.12604283
143Inositol phosphate metabolism_Homo sapiens_hsa005620.12600066
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.12239710
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11606636
146Arginine biosynthesis_Homo sapiens_hsa002200.11371250
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10597038
148Notch signaling pathway_Homo sapiens_hsa043300.10421111
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09939332
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08499884
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.07918647
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07061831
153Tight junction_Homo sapiens_hsa045300.06129739
154Cysteine and methionine metabolism_Homo sapiens_hsa002700.05163159
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.05086469
156Arginine and proline metabolism_Homo sapiens_hsa003300.04584131
157Type II diabetes mellitus_Homo sapiens_hsa049300.04307392
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.03662550

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