NXPE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transmembrane transport (GO:1902358)9.06743422
2sulfate transport (GO:0008272)7.50779270
3flavonoid metabolic process (GO:0009812)7.21258020
4cellular glucuronidation (GO:0052695)7.21222397
5glucuronate metabolic process (GO:0019585)6.85736147
6uronic acid metabolic process (GO:0006063)6.85736147
7bicarbonate transport (GO:0015701)6.38299281
8intestinal absorption (GO:0050892)6.35426939
9positive regulation of respiratory burst (GO:0060267)6.29516384
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.16389979
11positive regulation of fatty acid beta-oxidation (GO:0032000)5.86192920
12sperm capacitation (GO:0048240)5.52777662
13renal system process involved in regulation of blood volume (GO:0001977)5.36410589
14regulation of guanylate cyclase activity (GO:0031282)5.35381504
15transcytosis (GO:0045056)5.33208597
16glucocorticoid biosynthetic process (GO:0006704)5.16226755
17purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.15143624
183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.15143624
19glomerular filtration (GO:0003094)5.06614042
20oligosaccharide biosynthetic process (GO:0009312)5.05313433
21maintenance of gastrointestinal epithelium (GO:0030277)5.03889687
22bile acid and bile salt transport (GO:0015721)4.98933977
23phenylpropanoid metabolic process (GO:0009698)4.78865461
24positive regulation of synaptic transmission, GABAergic (GO:0032230)4.66838494
25calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.62331948
26renal filtration (GO:0097205)4.58894749
27positive regulation of fatty acid oxidation (GO:0046321)4.55718075
28ethanol oxidation (GO:0006069)4.55148790
29regulation of vitamin metabolic process (GO:0030656)4.53080970
30receptor guanylyl cyclase signaling pathway (GO:0007168)4.47979979
31O-glycan processing (GO:0016266)4.42072431
32negative regulation of myotube differentiation (GO:0010832)4.40145907
33regulation of intracellular pH (GO:0051453)4.37907879
34regulation of respiratory burst (GO:0060263)4.23991451
35UDP-N-acetylglucosamine metabolic process (GO:0006047)4.21991656
36one-carbon metabolic process (GO:0006730)4.20986994
37regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.17998645
38endocrine process (GO:0050886)4.17998645
39regulation of systemic arterial blood pressure by hormone (GO:0001990)4.17998645
40cGMP-mediated signaling (GO:0019934)4.05968415
41regulation of cellular pH (GO:0030641)4.04368990
42sulfur compound transport (GO:0072348)3.97730488
43lipid translocation (GO:0034204)3.88844997
44phospholipid translocation (GO:0045332)3.88844997
45desmosome organization (GO:0002934)3.86511335
46regulation of fatty acid beta-oxidation (GO:0031998)3.85906605
47regulation of pH (GO:0006885)3.85600345
48renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.82087137
49regulation of cholesterol homeostasis (GO:2000188)3.80859762
50regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.74284652
51regulation of systemic arterial blood pressure (GO:0003073)3.67046957
52sodium ion homeostasis (GO:0055078)3.66523979
53drug transmembrane transport (GO:0006855)3.66322923
54intestinal epithelial cell development (GO:0060576)3.65798997
55ethanol metabolic process (GO:0006067)3.58350992
56ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.54381386
57nucleoside bisphosphate biosynthetic process (GO:0033866)3.54381386
58purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.54381386
59monovalent inorganic cation homeostasis (GO:0055067)3.52647339
60response to acidic pH (GO:0010447)3.47534856
61epithelial structure maintenance (GO:0010669)3.46469477
62excretion (GO:0007588)3.45532486
63digestive system process (GO:0022600)3.43935210
64thrombin receptor signaling pathway (GO:0070493)3.41259500
65labyrinthine layer development (GO:0060711)3.41133821
66epoxygenase P450 pathway (GO:0019373)3.40728474
67positive regulation of pseudopodium assembly (GO:0031274)3.38256762
68cellular ketone body metabolic process (GO:0046950)3.36571582
69negative regulation of leukocyte chemotaxis (GO:0002689)3.35588724
70positive regulation of guanylate cyclase activity (GO:0031284)3.34786847
71cellular response to pH (GO:0071467)3.34401078
72cellular monovalent inorganic cation homeostasis (GO:0030004)3.32895877
73sulfur amino acid catabolic process (GO:0000098)3.31649329
74regulation of cGMP biosynthetic process (GO:0030826)3.30958231
75positive regulation of systemic arterial blood pressure (GO:0003084)3.16485378
76regulation of cellular extravasation (GO:0002691)3.15640311
77actin filament depolymerization (GO:0030042)3.15027500
78receptor recycling (GO:0001881)3.14371068
79ventricular cardiac muscle cell action potential (GO:0086005)3.14120098
80intermediate filament organization (GO:0045109)3.08866423
81drug metabolic process (GO:0017144)3.08526075
82pyrimidine-containing compound transmembrane transport (GO:0072531)3.07700149
83drug transport (GO:0015893)3.06798879
84regulation of pseudopodium assembly (GO:0031272)3.02103740
85membrane hyperpolarization (GO:0060081)2.99586616
86ketone body metabolic process (GO:1902224)2.94244184
87nucleotide-sugar biosynthetic process (GO:0009226)2.93774335
88positive regulation of lipid catabolic process (GO:0050996)2.91591844
89inorganic anion transmembrane transport (GO:0098661)2.90970634
90regulation of membrane lipid distribution (GO:0097035)2.90749022
91negative regulation of protein tyrosine kinase activity (GO:0061099)2.89923609
92auditory receptor cell differentiation (GO:0042491)2.89854840
93striated muscle atrophy (GO:0014891)2.87545368
94fucosylation (GO:0036065)2.85724950
95regulation of protein glycosylation (GO:0060049)2.80706228
96chloride transmembrane transport (GO:1902476)2.75849391
97eosinophil chemotaxis (GO:0048245)2.75506550
98protein O-linked glycosylation (GO:0006493)2.74905147
99sphingomyelin metabolic process (GO:0006684)2.74832176
100regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.74128613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.30198901
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86337233
3SOX2_27498859_Chip-Seq_STOMACH_Mouse2.80012931
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.72219660
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.66067476
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.63546056
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.37431037
8GATA4_25053715_ChIP-Seq_YYC3_Human2.37365004
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34997801
10FOXO3_23340844_ChIP-Seq_DLD1_Human2.34942008
11DROSHA_22980978_ChIP-Seq_HELA_Human2.32938557
12GATA6_25053715_ChIP-Seq_YYC3_Human2.20782305
13SOX2_20726797_ChIP-Seq_SW620_Human2.20503159
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.17977121
15BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.98032917
16ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.91631193
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84895396
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82836176
19TCF4_18268006_ChIP-ChIP_LS174T_Human1.82395010
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.80393731
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.74311010
22CDX2_22108803_ChIP-Seq_LS180_Human1.70486316
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70064576
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63618391
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.60316965
26CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59365243
27KLF5_25053715_ChIP-Seq_YYC3_Human1.58364602
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.57386497
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56368794
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48724755
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.46119482
32FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.44478419
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44436224
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43611694
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41508321
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39057045
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35144611
38PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33622918
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33042688
40FOXA1_25552417_ChIP-Seq_VCAP_Human1.32978441
41GATA1_22025678_ChIP-Seq_K562_Human1.31328981
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26818359
43CEBPB_22108803_ChIP-Seq_LS180_Human1.20369841
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19945185
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14492338
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.11410126
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10804043
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.10397927
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.10011088
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09969225
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07836765
52RXR_22108803_ChIP-Seq_LS180_Human1.07495042
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06719128
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04913633
55BCAT_22108803_ChIP-Seq_LS180_Human1.00311316
56CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99193555
57GATA1_19941826_ChIP-Seq_K562_Human0.98845063
58AHR_22903824_ChIP-Seq_MCF-7_Human0.94938123
59FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94748051
60CJUN_26792858_Chip-Seq_BT549_Human0.94571148
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93574393
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93032042
63HNF4A_19822575_ChIP-Seq_HepG2_Human0.92405120
64ESR1_20079471_ChIP-ChIP_T-47D_Human0.91863610
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91858575
66GATA2_19941826_ChIP-Seq_K562_Human0.91110206
67TCF4_22108803_ChIP-Seq_LS180_Human0.90116440
68TP53_16413492_ChIP-PET_HCT116_Human0.88456789
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87773788
70P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87246474
71GATA1_26923725_Chip-Seq_HPCs_Mouse0.86318187
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85586482
73TP63_23658742_ChIP-Seq_EP156T_Human0.85427288
74FLI1_27457419_Chip-Seq_LIVER_Mouse0.84361483
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83781472
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82612588
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81859205
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81256589
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80547150
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80439870
81VDR_22108803_ChIP-Seq_LS180_Human0.79334494
82GATA3_24758297_ChIP-Seq_MCF-7_Human0.79011810
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78158693
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.77662501
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77139097
86PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76820979
87EZH2_27294783_Chip-Seq_ESCs_Mouse0.75595775
88WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74194352
89STAT1_20625510_ChIP-Seq_HELA_Human0.74139293
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73943847
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72878440
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.72846802
93NANOG_20526341_ChIP-Seq_ESCs_Human0.71825692
94AR_25329375_ChIP-Seq_VCAP_Human0.71226497
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.71099278
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70857118
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.69979620
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.69941874
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.69344789
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.68819181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.43402128
2MP0004043_abnormal_pH_regulation5.65484722
3MP0010234_abnormal_vibrissa_follicle4.59432238
4MP0003866_abnormal_defecation4.20365429
5MP0010352_gastrointestinal_tract_polyps3.59618554
6MP0004147_increased_porphyrin_level3.33884462
7MP0001664_abnormal_digestion3.33336697
8MP0001663_abnormal_digestive_system3.27269672
9MP0005085_abnormal_gallbladder_physiolo3.26863261
10MP0001765_abnormal_ion_homeostasis2.90073416
11MP0003868_abnormal_feces_composition2.88141258
12MP0004264_abnormal_extraembryonic_tissu2.87590633
13MP0005381_digestive/alimentary_phenotyp2.84248063
14MP0005365_abnormal_bile_salt2.67556706
15MP0000477_abnormal_intestine_morphology2.59800818
16MP0003183_abnormal_peptide_metabolism2.54579556
17MP0010155_abnormal_intestine_physiology2.54454956
18MP0001873_stomach_inflammation2.49737239
19MP0002138_abnormal_hepatobiliary_system2.43112222
20MP0000490_abnormal_crypts_of2.36603985
21MP0005670_abnormal_white_adipose2.16954005
22MP0009379_abnormal_foot_pigmentation2.14740277
23MP0002009_preneoplasia2.07208493
24MP0005636_abnormal_mineral_homeostasis1.89209680
25MP0001666_abnormal_nutrient_absorption1.79193644
26MP0003252_abnormal_bile_duct1.67087302
27MP0000465_gastrointestinal_hemorrhage1.66824820
28MP0000230_abnormal_systemic_arterial1.60177065
29MP0000462_abnormal_digestive_system1.58226608
30MP0004782_abnormal_surfactant_physiolog1.56162462
31MP0002796_impaired_skin_barrier1.41716915
32MP0005360_urolithiasis1.36084035
33MP0005166_decreased_susceptibility_to1.30184518
34MP0001756_abnormal_urination1.24612494
35MP0000537_abnormal_urethra_morphology1.22557572
36MP0002098_abnormal_vibrissa_morphology1.20361229
37MP0005409_darkened_coat_color1.19736446
38MP0003303_peritoneal_inflammation1.18827104
39MP0009643_abnormal_urine_homeostasis1.17051163
40MP0000467_abnormal_esophagus_morphology1.16671011
41MP0002136_abnormal_kidney_physiology1.15575863
42MP0003724_increased_susceptibility_to1.13668424
43MP0008872_abnormal_physiological_respon1.08934460
44MP0000470_abnormal_stomach_morphology1.06946652
45MP0002277_abnormal_respiratory_mucosa1.05062470
46MP0000678_abnormal_parathyroid_gland1.04286365
47MP0003283_abnormal_digestive_organ1.03231018
48MP0002166_altered_tumor_susceptibility1.02252499
49MP0003300_gastrointestinal_ulcer1.01914318
50MP0001485_abnormal_pinna_reflex1.01647572
51MP0005310_abnormal_salivary_gland1.00894085
52MP0001188_hyperpigmentation0.99404221
53MP0010678_abnormal_skin_adnexa0.98814718
54MP0005319_abnormal_enzyme/_coenzyme0.97113244
55MP0003045_fibrosis0.95413565
56MP0002896_abnormal_bone_mineralization0.94967839
57MP0002006_tumorigenesis0.94123781
58MP0001501_abnormal_sleep_pattern0.91699838
59MP0002822_catalepsy0.90535517
60MP0004019_abnormal_vitamin_homeostasis0.90417285
61MP0000566_synostosis0.90147956
62MP0005666_abnormal_adipose_tissue0.88954780
63MP0009785_altered_susceptibility_to0.86976115
64MP0002876_abnormal_thyroid_physiology0.86305448
65MP0004484_altered_response_of0.84050726
66MP0005501_abnormal_skin_physiology0.82130804
67MP0001764_abnormal_homeostasis0.78597541
68MP0010329_abnormal_lipoprotein_level0.77012101
69MP0002118_abnormal_lipid_homeostasis0.75139142
70MP0005595_abnormal_vascular_smooth0.74229469
71MP0003879_abnormal_hair_cell0.73244139
72MP0005165_increased_susceptibility_to0.70574720
73MP0000538_abnormal_urinary_bladder0.70212621
74MP0004858_abnormal_nervous_system0.68586826
75MP0005332_abnormal_amino_acid0.68408638
76MP0000609_abnormal_liver_physiology0.68312069
77MP0009780_abnormal_chondrocyte_physiolo0.64785182
78MP0003693_abnormal_embryo_hatching0.61942135
79MP0000613_abnormal_salivary_gland0.60842808
80MP0003567_abnormal_fetal_cardiomyocyte0.60486570
81MP0002971_abnormal_brown_adipose0.60307706
82MP0001216_abnormal_epidermal_layer0.59828049
83MP0004947_skin_inflammation0.59495343
84MP0004215_abnormal_myocardial_fiber0.58098251
85MP0009115_abnormal_fat_cell0.57411640
86MP0003953_abnormal_hormone_level0.56978744
87MP0002733_abnormal_thermal_nociception0.56771086
88MP0001845_abnormal_inflammatory_respons0.55761116
89MP0005025_abnormal_response_to0.55040673
90MP0003329_amyloid_beta_deposits0.53905304
91MP0001849_ear_inflammation0.51457249
92MP0000377_abnormal_hair_follicle0.51417171
93MP0008875_abnormal_xenobiotic_pharmacok0.50996391
94MP0004270_analgesia0.49202238
95MP0005584_abnormal_enzyme/coenzyme_acti0.49144085
96MP0008961_abnormal_basal_metabolism0.49090220
97MP0006082_CNS_inflammation0.47641919
98MP0005448_abnormal_energy_balance0.47516918
99MP0002148_abnormal_hypersensitivity_rea0.47403768
100MP0009333_abnormal_splenocyte_physiolog0.46071387

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)8.67705086
2Decreased circulating renin level (HP:0003351)8.15495264
3Abnormality of renin-angiotensin system (HP:0000847)7.91662223
4Flat acetabular roof (HP:0003180)7.03607508
5Abnormality of chloride homeostasis (HP:0011422)6.25330206
6Hyperaldosteronism (HP:0000859)5.96794815
7Alkalosis (HP:0001948)5.27572513
8Neonatal short-limb short stature (HP:0008921)5.09372829
9Right ventricular cardiomyopathy (HP:0011663)4.79699361
10Hyponatremia (HP:0002902)4.75281596
11Flat capital femoral epiphysis (HP:0003370)4.70365960
12Flattened epiphyses (HP:0003071)4.41533144
13Abnormality of the distal phalanx of the thumb (HP:0009617)4.32639816
14Conjugated hyperbilirubinemia (HP:0002908)4.21391656
15Hypokalemia (HP:0002900)4.13914409
16Abdominal distention (HP:0003270)4.06677339
17Abnormality of potassium homeostasis (HP:0011042)4.03309348
18Ileus (HP:0002595)3.95045357
19Hyperkalemia (HP:0002153)3.92128724
20Visceral angiomatosis (HP:0100761)3.60769821
21Abnormality of sodium homeostasis (HP:0010931)3.57108874
22Intrahepatic cholestasis (HP:0001406)3.56628329
23Spinal cord compression (HP:0002176)3.56247975
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.53757306
25Large earlobe (HP:0009748)3.39192513
26Vertebral clefting (HP:0008428)3.36965104
27Breech presentation (HP:0001623)3.33907439
28Abnormal vertebral ossification (HP:0100569)3.25782451
29Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.24773262
30Vertebral hypoplasia (HP:0008417)3.24773262
31Hemangiomatosis (HP:0007461)3.23270737
32Symphalangism affecting the phalanges of the hand (HP:0009773)3.15367011
33Abnormal biliary tract morphology (HP:0012440)3.00574474
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98284020
35Adrenal overactivity (HP:0002717)2.94565158
36Irregular epiphyses (HP:0010582)2.94125346
37Abnormal tarsal ossification (HP:0008369)2.91851767
38Hip contracture (HP:0003273)2.82245870
39Hemorrhage of the eye (HP:0011885)2.71193094
40Malnutrition (HP:0004395)2.62011403
41Pili torti (HP:0003777)2.61706389
42Abnormal cartilage morphology (HP:0002763)2.60725174
43Syncope (HP:0001279)2.58053687
44Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.55079202
45Congenital sensorineural hearing impairment (HP:0008527)2.48807765
46Cystic hygroma (HP:0000476)2.43716742
47Curly hair (HP:0002212)2.40085964
48Palpitations (HP:0001962)2.37291357
49Hoarse voice (HP:0001609)2.36491143
50Dehydration (HP:0001944)2.34440638
51Renal tubular acidosis (HP:0001947)2.33282532
52Abnormality of carpal bone ossification (HP:0006257)2.30882731
53Hydroxyprolinuria (HP:0003080)2.29531085
54Abnormality of proline metabolism (HP:0010907)2.29531085
55Abnormality of small intestinal villus morphology (HP:0011472)2.21116264
56Villous atrophy (HP:0011473)2.21116264
57Abnormal foot bone ossification (HP:0010675)2.20953025
58Chronic bronchitis (HP:0004469)2.20870024
59Fat malabsorption (HP:0002630)2.20704209
60Aplasia/hypoplasia of the femur (HP:0005613)2.20405301
61Biliary tract neoplasm (HP:0100574)2.18201758
62Ventricular fibrillation (HP:0001663)2.13973742
63Abnormality of the 1st metacarpal (HP:0010009)2.12883871
64Abnormality of the vitamin B12 metabolism (HP:0004341)2.12766589
65Short middle phalanx of finger (HP:0005819)2.09880008
66Stillbirth (HP:0003826)2.08635041
67Abnormal hand bone ossification (HP:0010660)2.00794016
68Hyperactive renin-angiotensin system (HP:0000841)11.5191219
69Focal segmental glomerulosclerosis (HP:0000097)1.99943289
70Abnormal hair laboratory examination (HP:0003328)1.97009451
71Chronic diarrhea (HP:0002028)1.96762193
72Abnormality of vitamin B metabolism (HP:0004340)1.93744564
73Severe short stature (HP:0003510)1.91598169
74Hip dysplasia (HP:0001385)1.90858177
75Limited hip movement (HP:0008800)1.89318025
76Increased circulating renin level (HP:0000848)1.87987468
77Increased density of long bones (HP:0006392)1.84515070
78Abnormal ossification of hand bones (HP:0005921)1.79167966
79Rectal prolapse (HP:0002035)1.76248403
80Bundle branch block (HP:0011710)1.73484349
81Neoplasm of the rectum (HP:0100743)1.71714124
82Thin bony cortex (HP:0002753)1.70463173
83Hyperparathyroidism (HP:0000843)1.68194972
84Bone cyst (HP:0012062)1.68177869
85Short phalanx of the thumb (HP:0009660)1.66589907
86Neoplasm of the small intestine (HP:0100833)1.66518118
87Protuberant abdomen (HP:0001538)1.66282609
88Hypotension (HP:0002615)1.65140083
89Broad metatarsal (HP:0001783)1.64244121
90Abnormality of the acetabulum (HP:0003170)1.58920726
91Abnormality of vitamin metabolism (HP:0100508)1.58834106
92Late onset (HP:0003584)1.58035441
93Hyperammonemia (HP:0001987)1.54869833
94Toxemia of pregnancy (HP:0100603)1.53530070
95Glomerulosclerosis (HP:0000096)1.52727507
96Renal salt wasting (HP:0000127)1.51633056
97Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.49936988
98Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.48655721
99Thickened nuchal skin fold (HP:0000474)1.48498239
100Overfolded helix (HP:0000396)1.48203525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA6.86889163
2ACVR1B6.21689809
3MST1R5.77271411
4LMTK25.01635876
5EPHA24.64165083
6RIPK13.65331379
7STK242.93469331
8STK392.88450416
9MET2.35634066
10EPHB22.29229197
11FRK1.87170069
12WNK41.85302468
13OXSR11.83827855
14PRKG21.82663821
15MAP3K101.45659232
16MYLK1.33557841
17PTK61.24771890
18ERN11.15085060
19MAPKAPK31.13561615
20PDK21.09692806
21MAP3K121.04780000
22PRKAA20.99549079
23TAOK30.98350483
24DDR20.94794614
25ERBB20.90222130
26CAMK2D0.86459304
27TNIK0.85783635
28STK30.84236129
29MAP2K20.84109911
30RIPK40.78672825
31MAP3K20.78093448
32PDPK10.78046543
33MAPK110.77760516
34MAP2K60.77121071
35MATK0.71969380
36EPHB10.67438850
37ABL20.61773678
38EPHA30.60984322
39GRK10.60933478
40PDK10.59404063
41TESK20.58465451
42FGFR30.55893876
43TRPM70.53273522
44TAOK10.52503694
45EEF2K0.52138270
46NLK0.49850369
47CDK190.49359251
48PRKACG0.47769057
49ADRBK20.47467519
50MST40.44710839
51TYK20.44005383
52MAPKAPK20.43888196
53TESK10.42511949
54WNK10.41554083
55SRC0.41259631
56ADRBK10.41100523
57MAP2K10.41022547
58IRAK10.40289670
59PRKCA0.39536081
60CASK0.38957419
61INSRR0.38629925
62PRKAA10.38605564
63FER0.37463887
64RPS6KA20.35220401
65CSNK1A10.33543667
66PTK20.32433768
67CDC42BPA0.31916563
68DMPK0.31363331
69FGFR40.30521934
70BMPR20.28557338
71MUSK0.28028743
72EPHA40.26418760
73PRPF4B0.25592770
74GRK60.25512899
75FYN0.25406760
76RPS6KA60.24756188
77PNCK0.24622057
78RET0.23906751
79PRKCB0.23601693
80BMPR1B0.23461984
81ROCK10.22344532
82IGF1R0.22057465
83MAPK70.21408795
84MELK0.20938648
85PRKCQ0.20854674
86MAP3K10.20602259
87NTRK10.18408811
88PRKCE0.18306454
89CHUK0.18037071
90PAK40.17748930
91LYN0.17533371
92NEK60.15922576
93STK38L0.15186116
94JAK20.14790422
95RPS6KB10.14310004
96MAP3K140.14189491
97PRKCD0.13790887
98YES10.13628573
99PRKCZ0.13413353
100SGK10.13377746

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.17883068
2Sulfur metabolism_Homo sapiens_hsa009204.90797030
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.35596049
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.56543006
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39381418
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.99527244
7Mineral absorption_Homo sapiens_hsa049782.76147417
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71070964
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.54540043
10Caffeine metabolism_Homo sapiens_hsa002322.32798461
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.00964465
12Drug metabolism - other enzymes_Homo sapiens_hsa009831.94220819
13Starch and sucrose metabolism_Homo sapiens_hsa005001.93957748
14Retinol metabolism_Homo sapiens_hsa008301.90973143
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88154204
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.84747124
17Bile secretion_Homo sapiens_hsa049761.84169264
18Histidine metabolism_Homo sapiens_hsa003401.78091672
19Pancreatic secretion_Homo sapiens_hsa049721.77196178
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.75150351
21Fat digestion and absorption_Homo sapiens_hsa049751.70770013
22Fatty acid degradation_Homo sapiens_hsa000711.64734849
23Chemical carcinogenesis_Homo sapiens_hsa052041.62717935
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58998300
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50631796
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44759984
27PPAR signaling pathway_Homo sapiens_hsa033201.42458914
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40044083
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.23834020
30Renin-angiotensin system_Homo sapiens_hsa046141.20237149
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.10758735
32Arginine biosynthesis_Homo sapiens_hsa002201.10051552
33Tryptophan metabolism_Homo sapiens_hsa003801.07245682
34Butanoate metabolism_Homo sapiens_hsa006500.97895171
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96200827
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94651208
37Renin secretion_Homo sapiens_hsa049240.94090395
38Sulfur relay system_Homo sapiens_hsa041220.91520873
39Arginine and proline metabolism_Homo sapiens_hsa003300.88311901
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86645880
41Protein digestion and absorption_Homo sapiens_hsa049740.80726295
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76016633
43Tight junction_Homo sapiens_hsa045300.75472492
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.70239300
45Glycerolipid metabolism_Homo sapiens_hsa005610.68756610
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68331107
47Asthma_Homo sapiens_hsa053100.67757459
48Other glycan degradation_Homo sapiens_hsa005110.67337884
49Fructose and mannose metabolism_Homo sapiens_hsa000510.53428442
50Fatty acid metabolism_Homo sapiens_hsa012120.50298619
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49916794
52Sphingolipid metabolism_Homo sapiens_hsa006000.49502098
53Linoleic acid metabolism_Homo sapiens_hsa005910.49162319
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48458706
55Gastric acid secretion_Homo sapiens_hsa049710.45233408
56Galactose metabolism_Homo sapiens_hsa000520.44633595
57Tyrosine metabolism_Homo sapiens_hsa003500.44236687
58Propanoate metabolism_Homo sapiens_hsa006400.40242752
59Phenylalanine metabolism_Homo sapiens_hsa003600.37766630
60Allograft rejection_Homo sapiens_hsa053300.35822936
61Graft-versus-host disease_Homo sapiens_hsa053320.35612361
62Hepatitis C_Homo sapiens_hsa051600.35491805
63Taste transduction_Homo sapiens_hsa047420.35454763
64Ether lipid metabolism_Homo sapiens_hsa005650.35385231
65Autoimmune thyroid disease_Homo sapiens_hsa053200.35262538
66Arachidonic acid metabolism_Homo sapiens_hsa005900.34638177
67Thyroid hormone synthesis_Homo sapiens_hsa049180.33626603
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33471401
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32811250
70African trypanosomiasis_Homo sapiens_hsa051430.29007735
71Long-term depression_Homo sapiens_hsa047300.28592740
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26920867
73Insulin resistance_Homo sapiens_hsa049310.26774749
74Salivary secretion_Homo sapiens_hsa049700.26682978
75Dorso-ventral axis formation_Homo sapiens_hsa043200.26404780
76Amphetamine addiction_Homo sapiens_hsa050310.26092210
77ABC transporters_Homo sapiens_hsa020100.25634458
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24836419
79Peroxisome_Homo sapiens_hsa041460.24280583
80Glutathione metabolism_Homo sapiens_hsa004800.22851595
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.21238354
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.19728922
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.17615991
84Staphylococcus aureus infection_Homo sapiens_hsa051500.16794092
85Vitamin digestion and absorption_Homo sapiens_hsa049770.16734812
86Type I diabetes mellitus_Homo sapiens_hsa049400.16221642
87Insulin secretion_Homo sapiens_hsa049110.15170622
88Choline metabolism in cancer_Homo sapiens_hsa052310.14818955
89Pyruvate metabolism_Homo sapiens_hsa006200.13697554
90GnRH signaling pathway_Homo sapiens_hsa049120.12039218
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10224530
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.07792112
93Fatty acid biosynthesis_Homo sapiens_hsa000610.07638657
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.07507916
95Metabolic pathways_Homo sapiens_hsa011000.05610174
96Inositol phosphate metabolism_Homo sapiens_hsa005620.05290168
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.03642041
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.02751104
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02606819
100Antigen processing and presentation_Homo sapiens_hsa046120.01202076

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