NXPE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)8.99942049
2porphyrin-containing compound biosynthetic process (GO:0006779)8.55777999
3phenylpropanoid metabolic process (GO:0009698)8.02511725
4tetrapyrrole biosynthetic process (GO:0033014)7.68729519
5heme metabolic process (GO:0042168)7.66294971
6porphyrin-containing compound metabolic process (GO:0006778)7.32601400
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.32263789
8erythrocyte maturation (GO:0043249)5.94955590
9regulation of cellular extravasation (GO:0002691)5.85582272
10sulfate transmembrane transport (GO:1902358)5.47714322
11glucocorticoid biosynthetic process (GO:0006704)5.35853586
12response to methylmercury (GO:0051597)5.12928877
13cysteine metabolic process (GO:0006534)5.12642424
14cellular glucuronidation (GO:0052695)5.09748046
15hemoglobin metabolic process (GO:0020027)5.08357259
16angiotensin maturation (GO:0002003)5.06781964
17lysine metabolic process (GO:0006553)5.05058432
18lysine catabolic process (GO:0006554)5.05058432
19intestinal absorption (GO:0050892)5.03831812
20uronic acid metabolic process (GO:0006063)4.97748295
21glucuronate metabolic process (GO:0019585)4.97748295
22protein targeting to Golgi (GO:0000042)4.93231162
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.83313825
24L-phenylalanine catabolic process (GO:0006559)4.83313825
25bundle of His cell to Purkinje myocyte communication (GO:0086069)4.81679731
26tetrapyrrole metabolic process (GO:0033013)4.79696640
27flavonoid metabolic process (GO:0009812)4.79262673
28establishment of protein localization to Golgi (GO:0072600)4.74783167
29retrograde transport, vesicle recycling within Golgi (GO:0000301)4.69707873
30sperm capacitation (GO:0048240)4.69689330
31L-phenylalanine metabolic process (GO:0006558)4.64935007
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.64935007
33maintenance of gastrointestinal epithelium (GO:0030277)4.62154634
34regulation of guanylate cyclase activity (GO:0031282)4.59652807
35positive regulation of calcium ion import (GO:0090280)4.59150769
36aromatic amino acid family catabolic process (GO:0009074)4.51847730
37response to lead ion (GO:0010288)4.51634339
38very-low-density lipoprotein particle assembly (GO:0034379)4.46017031
39erythrocyte development (GO:0048821)4.42149453
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.38060747
41sulfate transport (GO:0008272)4.35404389
42regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.30328025
43endocrine process (GO:0050886)4.30328025
44regulation of systemic arterial blood pressure by hormone (GO:0001990)4.30328025
45RNA destabilization (GO:0050779)4.28878726
46plasma lipoprotein particle assembly (GO:0034377)4.26039336
47pigment biosynthetic process (GO:0046148)4.25539168
48regulation of bile acid biosynthetic process (GO:0070857)4.22867932
49tryptophan catabolic process (GO:0006569)4.22320937
50indole-containing compound catabolic process (GO:0042436)4.22320937
51indolalkylamine catabolic process (GO:0046218)4.22320937
52positive regulation of catecholamine secretion (GO:0033605)4.20894409
53receptor recycling (GO:0001881)4.20158216
54coronary vasculature morphogenesis (GO:0060977)4.12590092
55heme transport (GO:0015886)4.11926042
56one-carbon compound transport (GO:0019755)4.10547387
57kynurenine metabolic process (GO:0070189)4.06448652
58positive regulation of digestive system process (GO:0060456)4.06419564
59sperm motility (GO:0030317)4.00711025
60negative regulation of fibrinolysis (GO:0051918)3.99257256
61high-density lipoprotein particle remodeling (GO:0034375)3.98752412
62blood coagulation, intrinsic pathway (GO:0007597)3.96512631
63tryptophan metabolic process (GO:0006568)3.94428870
64pigment metabolic process (GO:0042440)3.90505096
65lipoprotein transport (GO:0042953)3.88390769
66positive regulation of guanylate cyclase activity (GO:0031284)3.86667690
67protein localization to Golgi apparatus (GO:0034067)3.85804991
68transcytosis (GO:0045056)3.85255936
69somite development (GO:0061053)3.82522981
70regulation of protein activation cascade (GO:2000257)3.82351056
71protein autoprocessing (GO:0016540)3.80752275
72bile acid biosynthetic process (GO:0006699)3.76925922
73regulation of fibrinolysis (GO:0051917)3.75351650
74response to insecticide (GO:0017085)3.73748282
75alpha-linolenic acid metabolic process (GO:0036109)3.72608620
76fat-soluble vitamin biosynthetic process (GO:0042362)3.72122641
77protein-lipid complex assembly (GO:0065005)3.71428428
78imidazole-containing compound metabolic process (GO:0052803)3.69095218
79sulfur amino acid catabolic process (GO:0000098)3.69088282
80regulation of systemic arterial blood pressure (GO:0003073)3.65361478
81cofactor catabolic process (GO:0051187)3.64636428
82glyoxylate metabolic process (GO:0046487)3.60616298
83regulation of complement activation (GO:0030449)3.57700105
84germ cell migration (GO:0008354)3.56589141
85ether metabolic process (GO:0018904)3.56486846
86reverse cholesterol transport (GO:0043691)3.56081787
87digestive system process (GO:0022600)3.54535889
88ethanol oxidation (GO:0006069)3.53534074
89protein carboxylation (GO:0018214)3.50639944
90peptidyl-glutamic acid carboxylation (GO:0017187)3.50639944
91negative regulation of norepinephrine secretion (GO:0010700)3.50145109
92cofactor biosynthetic process (GO:0051188)3.49436155
93urea metabolic process (GO:0019627)3.49430805
94urea cycle (GO:0000050)3.49430805
95response to nitrosative stress (GO:0051409)3.47102477
96positive regulation of monocyte chemotaxis (GO:0090026)3.45796095
97O-glycan processing (GO:0016266)3.44146748
98glomerular visceral epithelial cell development (GO:0072015)3.38727377
99phospholipid efflux (GO:0033700)3.38037210
100negative regulation of leukocyte migration (GO:0002686)3.37916651
101regulation of triglyceride catabolic process (GO:0010896)3.36985618
102glycine metabolic process (GO:0006544)3.36030411
103plasma lipoprotein particle remodeling (GO:0034369)3.35718108
104protein-lipid complex remodeling (GO:0034368)3.35718108
105macromolecular complex remodeling (GO:0034367)3.35718108
106complement activation, alternative pathway (GO:0006957)3.33444647
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33052628
108plasma lipoprotein particle organization (GO:0071827)3.32332350
109serine family amino acid metabolic process (GO:0009069)3.31228450
110nitrogen cycle metabolic process (GO:0071941)3.30178226
111cholesterol efflux (GO:0033344)3.29864338
112amino-acid betaine metabolic process (GO:0006577)3.29125682
113intestinal epithelial cell development (GO:0060576)3.28487841
114parturition (GO:0007567)3.24045876
115negative regulation of smooth muscle cell differentiation (GO:0051151)3.23448790
116epoxygenase P450 pathway (GO:0019373)3.22820849
117bile acid metabolic process (GO:0008206)3.21904379
118drug transmembrane transport (GO:0006855)3.20747292
119regulation of axon extension involved in axon guidance (GO:0048841)3.19489305
120aspartate family amino acid catabolic process (GO:0009068)3.17732352
121bicarbonate transport (GO:0015701)3.17725157
122regulation of cholesterol esterification (GO:0010872)3.17270287
123aromatic amino acid family metabolic process (GO:0009072)3.17261941
124alpha-amino acid catabolic process (GO:1901606)3.16796381
125membrane protein ectodomain proteolysis (GO:0006509)3.14596752
126sulfur compound transport (GO:0072348)3.14567177
127acylglycerol homeostasis (GO:0055090)3.14094175
128triglyceride homeostasis (GO:0070328)3.14094175
129drug metabolic process (GO:0017144)3.13195371
130serine family amino acid catabolic process (GO:0009071)3.12938279
131negative regulation of steroid metabolic process (GO:0045939)3.12211068
132positive regulation of lipoprotein lipase activity (GO:0051006)3.10373369
133positive regulation of triglyceride lipase activity (GO:0061365)3.10373369
134response to arsenic-containing substance (GO:0046685)3.09142181
135erythrocyte differentiation (GO:0030218)3.08314198
136UDP-N-acetylglucosamine metabolic process (GO:0006047)3.07038063
137folic acid-containing compound biosynthetic process (GO:0009396)3.06972129
138epithelial structure maintenance (GO:0010669)3.06892421
139nicotinamide nucleotide biosynthetic process (GO:0019359)3.06871279
140pyridine nucleotide biosynthetic process (GO:0019363)3.06871279
141protein-lipid complex subunit organization (GO:0071825)3.06668402
142serine family amino acid biosynthetic process (GO:0009070)3.06449458
143iron ion import (GO:0097286)3.06294529
144one-carbon metabolic process (GO:0006730)3.05797266
145regulation of gonadotropin secretion (GO:0032276)3.05722646
146regulation of cytokine secretion involved in immune response (GO:0002739)3.05066224
147glutamate metabolic process (GO:0006536)3.04394610
148membrane protein intracellular domain proteolysis (GO:0031293)3.03330338
149receptor guanylyl cyclase signaling pathway (GO:0007168)3.01606139
150protein activation cascade (GO:0072376)3.01343984
151NAD biosynthetic process (GO:0009435)3.00532255
152amine catabolic process (GO:0009310)3.00493873
153cellular biogenic amine catabolic process (GO:0042402)3.00493873
154bile acid and bile salt transport (GO:0015721)3.00246086
155plasma lipoprotein particle clearance (GO:0034381)2.99655771
156excretion (GO:0007588)2.99429919
157regulation of cholesterol homeostasis (GO:2000188)2.97417874
158homocysteine metabolic process (GO:0050667)2.96192766
159negative regulation of cholesterol transport (GO:0032375)2.95630107
160negative regulation of sterol transport (GO:0032372)2.95630107
161glomerular epithelial cell development (GO:0072310)2.95408153
162protein polyglutamylation (GO:0018095)2.93742258
163regulation of cGMP biosynthetic process (GO:0030826)2.93498411
164complement activation, classical pathway (GO:0006958)2.91545957
165renal system process involved in regulation of blood volume (GO:0001977)2.91498436
1663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.86308306
167purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.86308306
168glutathione biosynthetic process (GO:0006750)2.79966281
169regulation of calcium ion import (GO:0090279)2.78809550
170regulation of monocyte chemotaxis (GO:0090025)2.78096497
171dendritic spine morphogenesis (GO:0060997)2.75098246
172negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.74463952
173negative regulation of steroid biosynthetic process (GO:0010894)2.74119151
174alkaloid metabolic process (GO:0009820)2.74020470
175seminiferous tubule development (GO:0072520)2.73757409
176glomerular filtration (GO:0003094)2.73500166
177locomotory exploration behavior (GO:0035641)2.72287661
178vitamin A metabolic process (GO:0006776)2.66201259
179cellular response to ammonium ion (GO:0071242)2.66141394
180fusion of sperm to egg plasma membrane (GO:0007342)2.65872748
181regulation of axon guidance (GO:1902667)2.64799748
182regulation of vitamin metabolic process (GO:0030656)2.64491082
183heart valve formation (GO:0003188)2.63441968
184drug catabolic process (GO:0042737)2.62393867
185glucocorticoid metabolic process (GO:0008211)2.62091150
186negative regulation of protein tyrosine kinase activity (GO:0061099)2.61729890
187nonribosomal peptide biosynthetic process (GO:0019184)2.60674834
188thrombin receptor signaling pathway (GO:0070493)2.58359476
189digestion (GO:0007586)2.57849671
190drug transport (GO:0015893)2.55322186
191positive regulation of steroid hormone secretion (GO:2000833)2.54630971
192lipid translocation (GO:0034204)2.53005562
193phospholipid translocation (GO:0045332)2.53005562
194negative regulation of keratinocyte proliferation (GO:0010839)2.51770278
195ventricular trabecula myocardium morphogenesis (GO:0003222)2.50768369
196positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.48438464
197protoporphyrinogen IX metabolic process (GO:0046501)12.4859196
198protoporphyrinogen IX biosynthetic process (GO:0006782)11.9391334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.90825925
2E2F7_22180533_ChIP-Seq_HELA_Human6.19242210
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.92479035
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.47282228
5GATA1_22025678_ChIP-Seq_K562_Human4.30496325
6RXR_22158963_ChIP-Seq_LIVER_Mouse4.24726045
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.78797825
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.39758614
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06510662
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.05433064
11LXR_22158963_ChIP-Seq_LIVER_Mouse3.01072534
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.88790904
13TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.88537261
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82730934
15GATA1_19941826_ChIP-Seq_K562_Human2.74583028
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73177869
17GATA1_19941827_ChIP-Seq_MEL_Mouse2.57999202
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56523913
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.51292234
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.37071947
21KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.27531739
22SCL_19346495_ChIP-Seq_HPC-7_Human2.19587651
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16879740
24GATA1_22383799_ChIP-Seq_G1ME_Mouse2.14470054
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.09105969
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.08250370
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.99005945
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95224630
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.94918707
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.88150456
31GATA4_25053715_ChIP-Seq_YYC3_Human1.86305922
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82298403
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.80907123
34AR_21909140_ChIP-Seq_LNCAP_Human1.80111741
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79294142
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79126415
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78064590
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.76410984
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71139631
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69629230
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.69205105
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67489845
43CDX2_22108803_ChIP-Seq_LS180_Human1.63846442
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63774882
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60256631
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59938642
47GATA2_19941826_ChIP-Seq_K562_Human1.59671456
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57492425
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57273850
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55909603
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55522625
52RXR_22108803_ChIP-Seq_LS180_Human1.52988271
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52976063
54DROSHA_22980978_ChIP-Seq_HELA_Human1.52129207
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50604045
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.47868187
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45729802
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45653766
59ZNF263_19887448_ChIP-Seq_K562_Human1.43105624
60AR_25329375_ChIP-Seq_VCAP_Human1.42329940
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.42171954
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40404670
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40404670
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.39234681
65GATA6_25053715_ChIP-Seq_YYC3_Human1.38798293
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38691756
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.37790984
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.37556626
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35738498
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35621175
71CBP_20019798_ChIP-Seq_JUKART_Human1.35621175
72AHR_22903824_ChIP-Seq_MCF-7_Human1.34462783
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34450032
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34210387
75ER_23166858_ChIP-Seq_MCF-7_Human1.32805918
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32587666
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30946133
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30913485
79CJUN_26792858_Chip-Seq_BT549_Human1.30233660
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29652745
81SMAD4_21799915_ChIP-Seq_A2780_Human1.27987823
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25966645
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.25432847
84VDR_23849224_ChIP-Seq_CD4+_Human1.24722913
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24712422
86FUS_26573619_Chip-Seq_HEK293_Human1.24702749
87BCAT_22108803_ChIP-Seq_LS180_Human1.24521365
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.24231578
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24229891
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23905288
91TP63_23658742_ChIP-Seq_EP156T_Human1.23392333
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23153616
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23076182
94P300_19829295_ChIP-Seq_ESCs_Human1.22276645
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22110319
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.22052648
97TP53_18474530_ChIP-ChIP_U2OS_Human1.21045362
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.20854264
99VDR_22108803_ChIP-Seq_LS180_Human1.20539273
100SOX2_20726797_ChIP-Seq_SW620_Human1.20137024
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20085808
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19053507
103STAT3_23295773_ChIP-Seq_U87_Human1.18894352
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18681549
105MYC_22102868_ChIP-Seq_BL_Human1.18548206
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18291032
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18004086
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17996390
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16968320
110DCP1A_22483619_ChIP-Seq_HELA_Human1.16492249
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15063957
112KLF5_25053715_ChIP-Seq_YYC3_Human1.14708637
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.13804207
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11082253
115AR_21572438_ChIP-Seq_LNCaP_Human1.10764649
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.10165527
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09698437
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08971663
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08264299
120CEBPB_22108803_ChIP-Seq_LS180_Human1.07177804
121FOXP3_21729870_ChIP-Seq_TREG_Human1.06897907
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06244167
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06091849
124THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05875520
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05258206
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05213956
127TCF4_22108803_ChIP-Seq_LS180_Human1.04946476
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04930163
129ESR2_21235772_ChIP-Seq_MCF-7_Human1.04376359
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04311193
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04196774
132STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03939179
133TBL1_22424771_ChIP-Seq_293T_Human1.02761163
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01864111
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01595316
136ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00830350
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00612604
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00178114
139XRN2_22483619_ChIP-Seq_HELA_Human0.99967811
140IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99347054
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98759269
142HNFA_21074721_ChIP-Seq_CACO-2_Human0.98706645
143HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98598269
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.98446952
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.96877152
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.95877348
147CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95189434
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95147841
149ETV1_20927104_ChIP-Seq_GIST48_Human0.94384301
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94172493
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93481375
152NFYB_21822215_ChIP-Seq_K562_Human0.93474865
153GABP_19822575_ChIP-Seq_HepG2_Human0.93326490
154NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92547363
155TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92499925
156VDR_21846776_ChIP-Seq_THP-1_Human0.92085685
157HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91666977
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91345149
159MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91220946
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90653814
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89858427
162CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89683250
163VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89640539
164BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89482984
165RUNX1_27514584_Chip-Seq_MCF-7_Human0.89224676
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89217298
167EZH2_22144423_ChIP-Seq_EOC_Human0.89157940
168SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87402951
169MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87355072
170ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86822546
171E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85680302
172LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85169476
173PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84829702
174SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83955078
175KDM5A_27292631_Chip-Seq_BREAST_Human0.83601509
176CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82564757
177ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79790804
178CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.79217735
179PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78887445
180RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78632091
181MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78442041
182MYCN_18555785_ChIP-Seq_MESCs_Mouse0.76080080
183STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74932220
184NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74352553
185ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.72684487
186CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72161694
187NCOR1_26117541_ChIP-Seq_K562_Human0.70442519
188BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70166394
189FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.69088721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo8.06201582
2MP0004147_increased_porphyrin_level7.45189904
3MP0002139_abnormal_hepatobiliary_system5.79939086
4MP0005360_urolithiasis4.86612740
5MP0003183_abnormal_peptide_metabolism4.66772039
6MP0005085_abnormal_gallbladder_physiolo4.38177627
7MP0003806_abnormal_nucleotide_metabolis4.01919595
8MP0009278_abnormal_bone_marrow3.70899126
9MP0005365_abnormal_bile_salt3.63675572
10MP0004264_abnormal_extraembryonic_tissu3.55824922
11MP0005670_abnormal_white_adipose3.36608819
12MP0004782_abnormal_surfactant_physiolog3.34750833
13MP0005083_abnormal_biliary_tract3.29423918
14MP0008875_abnormal_xenobiotic_pharmacok3.22780775
15MP0009384_cardiac_valve_regurgitation2.99505974
16MP0006054_spinal_hemorrhage2.86536699
17MP0005410_abnormal_fertilization2.66853332
18MP0003866_abnormal_defecation2.52436354
19MP0010234_abnormal_vibrissa_follicle2.50956285
20MP0003252_abnormal_bile_duct2.45059119
21MP0004043_abnormal_pH_regulation2.44014312
22MP0010329_abnormal_lipoprotein_level2.31187744
23MP0003329_amyloid_beta_deposits2.14426737
24MP0005503_abnormal_tendon_morphology2.11298639
25MP0001765_abnormal_ion_homeostasis2.05881559
26MP0005636_abnormal_mineral_homeostasis1.96493257
27MP0001664_abnormal_digestion1.95047228
28MP0003186_abnormal_redox_activity1.93958469
29MP0002138_abnormal_hepatobiliary_system1.84533074
30MP0000609_abnormal_liver_physiology1.83740652
31MP0001545_abnormal_hematopoietic_system1.83737124
32MP0005397_hematopoietic_system_phenotyp1.83737124
33MP0001666_abnormal_nutrient_absorption1.74355073
34MP0009840_abnormal_foam_cell1.73990110
35MP0006036_abnormal_mitochondrial_physio1.68786627
36MP0000477_abnormal_intestine_morphology1.62456001
37MP0003111_abnormal_nucleus_morphology1.61387987
38MP0001485_abnormal_pinna_reflex1.60998941
39MP0001501_abnormal_sleep_pattern1.57001889
40MP0005332_abnormal_amino_acid1.55514365
41MP0001764_abnormal_homeostasis1.54272422
42MP0003191_abnormal_cellular_cholesterol1.52332060
43MP0005319_abnormal_enzyme/_coenzyme1.50815865
44MP0003868_abnormal_feces_composition1.46064054
45MP0003195_calcinosis1.43258434
46MP0010352_gastrointestinal_tract_polyps1.41813804
47MP0005381_digestive/alimentary_phenotyp1.39307946
48MP0001919_abnormal_reproductive_system1.36313871
49MP0009764_decreased_sensitivity_to1.36245098
50MP0010155_abnormal_intestine_physiology1.34672862
51MP0010094_abnormal_chromosome_stability1.33039723
52MP0002876_abnormal_thyroid_physiology1.32671533
53MP0005584_abnormal_enzyme/coenzyme_acti1.30790072
54MP0000230_abnormal_systemic_arterial1.30262622
55MP0009697_abnormal_copulation1.28237167
56MP0002118_abnormal_lipid_homeostasis1.26758469
57MP0000538_abnormal_urinary_bladder1.26723321
58MP0003879_abnormal_hair_cell1.26392506
59MP0002132_abnormal_respiratory_system1.25839161
60MP0005187_abnormal_penis_morphology1.25610753
61MP0003693_abnormal_embryo_hatching1.22615740
62MP0008057_abnormal_DNA_replication1.22260542
63MP0005666_abnormal_adipose_tissue1.20840737
64MP0005595_abnormal_vascular_smooth1.18401610
65MP0002396_abnormal_hematopoietic_system1.18038878
66MP0000598_abnormal_liver_morphology1.17771686
67MP0009643_abnormal_urine_homeostasis1.14915533
68MP0005310_abnormal_salivary_gland1.14064782
69MP0000462_abnormal_digestive_system1.13387427
70MP0002009_preneoplasia1.11842277
71MP0003077_abnormal_cell_cycle1.07322971
72MP0006138_congestive_heart_failure1.05611107
73MP0005409_darkened_coat_color1.03900684
74MP0005464_abnormal_platelet_physiology1.02610342
75MP0002998_abnormal_bone_remodeling1.02291270
76MP0005367_renal/urinary_system_phenotyp1.01610755
77MP0000516_abnormal_urinary_system1.01610755
78MP0001881_abnormal_mammary_gland1.00954487
79MP0003724_increased_susceptibility_to0.99869263
80MP0000249_abnormal_blood_vessel0.99409885
81MP0002102_abnormal_ear_morphology0.97790484
82MP0002108_abnormal_muscle_morphology0.97259451
83MP0009763_increased_sensitivity_to0.96479615
84MP0009115_abnormal_fat_cell0.95857850
85MP0008469_abnormal_protein_level0.95576147
86MP0005379_endocrine/exocrine_gland_phen0.95382476
87MP0008872_abnormal_physiological_respon0.94896430
88MP0002127_abnormal_cardiovascular_syste0.94520163
89MP0000685_abnormal_immune_system0.94405148
90MP0005647_abnormal_sex_gland0.92355012
91MP0005275_abnormal_skin_tensile0.91052250
92MP0010368_abnormal_lymphatic_system0.89767891
93MP0000689_abnormal_spleen_morphology0.89346162
94MP0004957_abnormal_blastocyst_morpholog0.88748693
95MP0004019_abnormal_vitamin_homeostasis0.88741386
96MP0003632_abnormal_nervous_system0.87599917
97MP0002896_abnormal_bone_mineralization0.86907772
98MP0002398_abnormal_bone_marrow0.86423196
99MP0003698_abnormal_male_reproductive0.86318253
100MP0002971_abnormal_brown_adipose0.83287754
101MP0000490_abnormal_crypts_of0.83074590
102MP0005376_homeostasis/metabolism_phenot0.82276126
103MP0006035_abnormal_mitochondrial_morpho0.81423068
104MP0009765_abnormal_xenobiotic_induced0.80790463
105MP0005377_hearing/vestibular/ear_phenot0.80688571
106MP0003878_abnormal_ear_physiology0.80688571
107MP0002722_abnormal_immune_system0.80444018
108MP0009333_abnormal_splenocyte_physiolog0.80335447
109MP0004858_abnormal_nervous_system0.80063464
110MP0001853_heart_inflammation0.79455597
111MP0005166_decreased_susceptibility_to0.77728974
112MP0005266_abnormal_metabolism0.76925995
113MP0002098_abnormal_vibrissa_morphology0.76055102
114MP0008775_abnormal_heart_ventricle0.75787762
115MP0001929_abnormal_gametogenesis0.74028360
116MP0002429_abnormal_blood_cell0.73187152
117MP0005395_other_phenotype0.73179914
118MP0009931_abnormal_skin_appearance0.70536090
119MP0000465_gastrointestinal_hemorrhage0.70004042
120MP0008961_abnormal_basal_metabolism0.68283170
121MP0004742_abnormal_vestibular_system0.67427138
122MP0009642_abnormal_blood_homeostasis0.66166145
123MP0005164_abnormal_response_to0.65882248
124MP0005508_abnormal_skeleton_morphology0.65538651
125MP0000026_abnormal_inner_ear0.64955002
126MP0004215_abnormal_myocardial_fiber0.64641674
127MP0003959_abnormal_lean_body0.62870680
128MP0001727_abnormal_embryo_implantation0.62827577
129MP0008058_abnormal_DNA_repair0.61056597
130MP0005551_abnormal_eye_electrophysiolog0.59936451
131MP0005167_abnormal_blood-brain_barrier0.59032611
132MP0005671_abnormal_response_to0.58656263
133MP0002019_abnormal_tumor_incidence0.57826165
134MP0001756_abnormal_urination0.57149875
135MP0001879_abnormal_lymphatic_vessel0.56977701
136MP0001243_abnormal_dermal_layer0.56659126
137MP0000467_abnormal_esophagus_morphology0.56543259
138MP0001663_abnormal_digestive_system0.55860583
139MP0002932_abnormal_joint_morphology0.54924905
140MP0005408_hypopigmentation0.54328624
141MP0005501_abnormal_skin_physiology0.53144208
142MP0010307_abnormal_tumor_latency0.52263283
143MP0003718_maternal_effect0.51689920
144MP0008873_increased_physiological_sensi0.50926829
145MP0002136_abnormal_kidney_physiology0.50925332
146MP0000604_amyloidosis0.50755526
147MP0003011_delayed_dark_adaptation0.50066931
148MP0001800_abnormal_humoral_immune0.48506373
149MP0002166_altered_tumor_susceptibility0.47487694
150MP0005334_abnormal_fat_pad0.47426075
151MP0003300_gastrointestinal_ulcer0.47224996
152MP0001873_stomach_inflammation0.46078416
153MP0005025_abnormal_response_to0.45958764
154MP0005220_abnormal_exocrine_pancreas0.45551800
155MP0001915_intracranial_hemorrhage0.44971791
156MP0001845_abnormal_inflammatory_respons0.44901537
157MP0000313_abnormal_cell_death0.44882539
158MP0005451_abnormal_body_composition0.43091321
159MP0001661_extended_life_span0.41909745
160MP0000350_abnormal_cell_proliferation0.41553237
161MP0000716_abnormal_immune_system0.40426994
162MP0002078_abnormal_glucose_homeostasis0.39230908
163MP0001835_abnormal_antigen_presentation0.38516689
164MP0003705_abnormal_hypodermis_morpholog0.36503910
165MP0002086_abnormal_extraembryonic_tissu0.36493460
166MP0002254_reproductive_system_inflammat0.36095588
167MP0002970_abnormal_white_adipose0.35136227

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.21414910
2Acanthocytosis (HP:0001927)7.17827970
3Hyperactive renin-angiotensin system (HP:0000841)6.65208746
4Hypochromic microcytic anemia (HP:0004840)6.33510227
5Reticulocytosis (HP:0001923)6.28644550
6Hyperbilirubinemia (HP:0002904)5.73034656
7Cholelithiasis (HP:0001081)5.36622489
8Abnormal gallbladder morphology (HP:0012437)5.00148920
9Abnormality of the costochondral junction (HP:0000919)4.75107110
10Decreased circulating renin level (HP:0003351)4.67574594
11Intrahepatic cholestasis (HP:0001406)4.61267905
12Widely patent fontanelles and sutures (HP:0004492)4.59677961
13Deep venous thrombosis (HP:0002625)4.58257753
14Metabolic alkalosis (HP:0200114)4.51427195
15Diaphragmatic weakness (HP:0009113)4.51333763
16Abnormality of renin-angiotensin system (HP:0000847)4.47977513
17Abnormality of reticulocytes (HP:0004312)4.40481211
18Prolonged partial thromboplastin time (HP:0003645)4.28319256
19Abnormality of aromatic amino acid family metabolism (HP:0004338)4.23972771
20Right ventricular cardiomyopathy (HP:0011663)4.23461718
21Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19298976
22Abnormal gallbladder physiology (HP:0012438)4.15557989
23Cholecystitis (HP:0001082)4.15557989
24Hypobetalipoproteinemia (HP:0003563)4.13425025
25Malnutrition (HP:0004395)3.94715344
26Flattened epiphyses (HP:0003071)3.89394340
27Cone-rod dystrophy (HP:0000548)3.84913650
28Neonatal short-limb short stature (HP:0008921)3.80515062
29Flat acetabular roof (HP:0003180)3.78836656
30Abnormality of proline metabolism (HP:0010907)3.76922818
31Hydroxyprolinuria (HP:0003080)3.76922818
32Hepatocellular carcinoma (HP:0001402)3.76703723
33Paralysis (HP:0003470)3.75236215
34Abnormality of the gallbladder (HP:0005264)3.69539874
35Abnormal number of erythroid precursors (HP:0012131)3.67514733
36Xanthomatosis (HP:0000991)3.64790685
37Tubulointerstitial nephritis (HP:0001970)3.64049742
38Hyperkalemia (HP:0002153)3.53467934
39Microcytic anemia (HP:0001935)3.49321743
40Polycythemia (HP:0001901)3.47620976
41Abnormality of chloride homeostasis (HP:0011422)3.45505085
42Ileus (HP:0002595)3.44875281
43Increased serum ferritin (HP:0003281)3.44561090
44Abnormality of iron homeostasis (HP:0011031)3.43451544
45Chronic hepatic failure (HP:0100626)3.41676489
46Abnormality of cells of the erythroid lineage (HP:0012130)3.39367908
47Hyperaldosteronism (HP:0000859)3.32702373
48Abnormality of transition element cation homeostasis (HP:0011030)3.26467022
49Abnormality of the distal phalanx of the thumb (HP:0009617)3.22538722
50Arterial tortuosity (HP:0005116)3.20465965
51Large earlobe (HP:0009748)3.20445907
52Joint hemorrhage (HP:0005261)3.17940592
53Wide cranial sutures (HP:0010537)3.14887703
54Flat capital femoral epiphysis (HP:0003370)3.13249146
55Hypochromic anemia (HP:0001931)3.12775268
56Hyperlipoproteinemia (HP:0010980)3.12155489
57Abnormal vertebral ossification (HP:0100569)3.11915479
58Vertebral clefting (HP:0008428)3.10188103
59Chronic diarrhea (HP:0002028)3.08802969
60Abdominal distention (HP:0003270)3.06331390
61Hyperammonemia (HP:0001987)3.05472810
62Hypolipoproteinemia (HP:0010981)3.04644782
63Asymmetric septal hypertrophy (HP:0001670)3.04354011
64Abnormality of potassium homeostasis (HP:0011042)2.99298189
65Alkalosis (HP:0001948)2.97621336
66Abnormality of pyrimidine metabolism (HP:0004353)2.89498808
67Abnormality of the common coagulation pathway (HP:0010990)2.85714355
68Nausea (HP:0002018)2.83857260
69Complement deficiency (HP:0004431)2.83491022
70Osteomalacia (HP:0002749)2.81780678
71Hypoglycemic coma (HP:0001325)2.77109236
72Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.76485278
73Vascular tortuosity (HP:0004948)2.71800591
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.70774276
75Insomnia (HP:0100785)2.68265978
76Cutaneous photosensitivity (HP:0000992)2.67795461
77Congenital sensorineural hearing impairment (HP:0008527)2.66035253
78Abnormality of the nasal septum (HP:0000419)2.62174261
79Focal segmental glomerulosclerosis (HP:0000097)2.62023762
80Pigmentary retinal degeneration (HP:0001146)2.59837719
81Abnormality of methionine metabolism (HP:0010901)2.59679400
82Abnormality of the intrinsic pathway (HP:0010989)2.58607789
83Enlarged epiphyses (HP:0010580)2.57655786
84Abnormality of the vitamin B12 metabolism (HP:0004341)2.56555050
85Birth length less than 3rd percentile (HP:0003561)2.55559894
86Bilateral sensorineural hearing impairment (HP:0008619)2.55231827
87Hypoalphalipoproteinemia (HP:0003233)2.55137692
88Hypokalemia (HP:0002900)2.52328514
89Abnormal biliary tract morphology (HP:0012440)2.50496367
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48384522
91Metabolic acidosis (HP:0001942)2.47822347
92Ketosis (HP:0001946)2.40681834
93Fat malabsorption (HP:0002630)2.39944523
94Prolonged bleeding time (HP:0003010)2.36071397
95Amelogenesis imperfecta (HP:0000705)2.34964061
96Epistaxis (HP:0000421)2.34858022
97Vertebral hypoplasia (HP:0008417)2.32569296
98Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.32569296
99Nonimmune hydrops fetalis (HP:0001790)2.32547988
100Abnormality of vitamin B metabolism (HP:0004340)2.30643503
101Chorioretinal atrophy (HP:0000533)2.29999935
102Abnormal tarsal ossification (HP:0008369)2.22175750
103Insulin-resistant diabetes mellitus (HP:0000831)2.21545727
104Confusion (HP:0001289)2.20083967
105Abnormality of sodium homeostasis (HP:0010931)2.18065150
106Epidermoid cyst (HP:0200040)2.16133644
107Abnormality of nucleobase metabolism (HP:0010932)2.14059277
108Cerebral palsy (HP:0100021)2.14048501
109Rickets (HP:0002748)2.13683728
110Hyperglycinemia (HP:0002154)2.13613316
111Glomerulosclerosis (HP:0000096)2.13316437
112Petechiae (HP:0000967)2.13244027
113Breech presentation (HP:0001623)2.13212021
114Subcapsular cataract (HP:0000523)2.12493528
115Global brain atrophy (HP:0002283)2.12401975
116Abnormality of complement system (HP:0005339)2.09177788
117Abnormality of fatty-acid metabolism (HP:0004359)2.09053662
118Brushfield spots (HP:0001088)2.08259325
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06528155
120Syncope (HP:0001279)2.03054006
121Thrombophlebitis (HP:0004418)2.02952510
122Growth hormone deficiency (HP:0000824)2.02854363
123Spastic diplegia (HP:0001264)2.01143671
124Increased circulating renin level (HP:0000848)2.00693538
125Polyphagia (HP:0002591)2.00534923
126Keratoconus (HP:0000563)2.00426722
127Increased corneal curvature (HP:0100692)2.00426722
128Abnormality of the heme biosynthetic pathway (HP:0010472)11.2429924
129Protuberant abdomen (HP:0001538)1.99610564
130Thin bony cortex (HP:0002753)1.99295205
131Hypercholesterolemia (HP:0003124)1.99174521
132Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98457296
133Dehydration (HP:0001944)1.98406467
134Cerebral edema (HP:0002181)1.95829197
135Vomiting (HP:0002013)1.94045168
136Delayed CNS myelination (HP:0002188)1.93729048
137Short phalanx of the thumb (HP:0009660)1.93677224
138Increased purine levels (HP:0004368)1.93496457
139Hyperuricemia (HP:0002149)1.93496457
140Abnormality of the diencephalon (HP:0010662)1.93081313
141Villous atrophy (HP:0011473)1.92318183
142Abnormality of small intestinal villus morphology (HP:0011472)1.92318183
143Hyponatremia (HP:0002902)1.90622155
144Short ribs (HP:0000773)1.89209690
145Abnormality of glycine metabolism (HP:0010895)1.89192603
146Abnormality of serine family amino acid metabolism (HP:0010894)1.89192603
147Depressed nasal tip (HP:0000437)1.88776830
148Abnormality of dental color (HP:0011073)1.85859487
149Generalized hyperpigmentation (HP:0007440)1.84564622
150Steatorrhea (HP:0002570)1.84477258
151Abnormality of serum amino acid levels (HP:0003112)1.83063735
152Visceral angiomatosis (HP:0100761)1.82114291
153Hypoplasia of the thymus (HP:0000778)1.80691481
154Abnormal hand bone ossification (HP:0010660)1.80629913
155Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79857573
156Dicarboxylic aciduria (HP:0003215)1.79857573
157Hyperglycinuria (HP:0003108)1.79662542
158Impaired platelet aggregation (HP:0003540)1.79465283
159Abnormal platelet function (HP:0011869)1.79465283
160Conjugated hyperbilirubinemia (HP:0002908)1.79382659
161Nephrolithiasis (HP:0000787)1.79341549
162Spontaneous abortion (HP:0005268)1.78703664
163Lethargy (HP:0001254)1.78700443
164Bone cyst (HP:0012062)1.77974065
165Renal tubular acidosis (HP:0001947)1.77405998
166Abnormality of purine metabolism (HP:0004352)1.76339511
167Hypertriglyceridemia (HP:0002155)1.76253987
168Gingival bleeding (HP:0000225)1.76085651
169Midline defect of the nose (HP:0004122)1.75702778
170Urticaria (HP:0001025)1.75208610
171Neoplasm of the liver (HP:0002896)1.72700160
172Macrocytic anemia (HP:0001972)1.72564079
173Abnormality of vitamin metabolism (HP:0100508)1.72412696
174Elevated hepatic transaminases (HP:0002910)1.72037978
175Menorrhagia (HP:0000132)1.71659782
176Lower limb hyperreflexia (HP:0002395)1.70722005
177Facial shape deformation (HP:0011334)1.69574622
178Potter facies (HP:0002009)1.69574622
179Delusions (HP:0000746)1.68571827
180Autoimmune thrombocytopenia (HP:0001973)1.66601768
181Pustule (HP:0200039)1.65592580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.26133261
2EPHB14.73749607
3PLK44.24896643
4EPHA33.76376613
5PIK3CA3.70186003
6TLK13.59155231
7STK393.51002850
8NME23.09441128
9CDC72.98422962
10EPHA22.89029190
11LMTK22.58127181
12STK42.57988223
13BCKDK2.56045312
14LATS12.53285581
15VRK12.52511775
16KDR2.52419072
17MET2.35713782
18STK242.09402831
19PNCK2.05676084
20STK102.01334636
21RIPK12.00578270
22OXSR11.98746537
23DYRK31.95843915
24ZAK1.90973883
25BRSK11.81770848
26WEE11.78791387
27BUB11.76375764
28NEK21.75877551
29TIE11.75769295
30ERN11.68339239
31TAOK31.63642395
32MAPK111.63515742
33NEK61.62317872
34FLT31.60984617
35STK38L1.59257364
36EPHB21.56185327
37PLK21.52634414
38BRSK21.51412659
39TYK21.50029888
40FRK1.47415283
41SCYL21.46249324
42GRK61.45329464
43MAP3K81.44588208
44PRKG21.44387620
45PIM11.43658464
46MAP3K101.43523399
47CDK121.41134190
48MAPK151.40290209
49MAP4K11.39941867
50TNIK1.37047224
51WNK41.31505729
52NEK11.30286374
53AURKB1.30277538
54TGFBR21.28093174
55ABL21.27091472
56JAK21.25284074
57DDR21.24810850
58STK161.20691762
59ACVR1B1.19288610
60CDK41.19173036
61CASK1.13570461
62MAP2K31.13073440
63CAMK1G1.12566290
64RPS6KA51.10631065
65SIK11.10358835
66PKN21.09703138
67TYRO31.05741478
68MAPK121.03900495
69MAP3K111.02835031
70ADRBK20.99075015
71CDK60.97803153
72AURKA0.96250013
73ERBB20.96137656
74GRK10.93949156
75NUAK10.93587707
76PBK0.93312396
77LRRK20.88444318
78SYK0.86078137
79EEF2K0.85969153
80TBK10.84695010
81PRKAA10.81596301
82PLK10.77396090
83IRAK30.75557600
84MAP2K20.75289866
85FGFR40.74724931
86PIM20.73182269
87MAP3K20.73073675
88IKBKE0.72460868
89LYN0.71537090
90DMPK0.71115833
91MAPKAPK50.70066834
92MAPKAPK20.69317212
93ATR0.68814437
94MAPKAPK30.68561328
95MAP4K20.67539811
96EIF2AK30.65204373
97AKT30.64930099
98TTK0.64241428
99PDK10.63794103
100PDPK10.59326931
101NLK0.58897170
102BRD40.58835656
103PTK60.58669117
104CDK70.57827902
105CHEK20.56285162
106JAK30.55511194
107ATM0.54896065
108STK380.54855585
109PDGFRA0.54677859
110DAPK20.53585333
111CDC42BPA0.53145895
112PRKAA20.52627253
113INSRR0.52541678
114EIF2AK20.52512603
115TRPM70.51530056
116PTK20.51197304
117CHEK10.50600674
118PIK3CG0.49806233
119RPS6KB20.49769478
120CSNK2A10.49121716
121WNK10.47902824
122NEK90.45594436
123FER0.45547963
124TESK10.44744008
125RPS6KA40.44727028
126PRKACG0.44013571
127PTK2B0.43418793
128DYRK1B0.41495203
129SRPK10.41389702
130CDK90.39830640
131MOS0.39750234
132KSR20.39226385
133ERBB30.39008909
134PRKCE0.38884530
135BMPR20.37518305
136CSNK2A20.37186659
137IKBKB0.37031035
138MAP2K10.36919000
139TRIB30.36502688
140MAP3K10.36056277
141CDK80.36016634
142GRK50.35788243
143CAMK2D0.35582243
144MYLK0.35387525
145STK30.34944815
146FGFR30.34865158
147PRKCQ0.34802927
148DYRK1A0.34368042
149PRKCZ0.34131964
150CAMK1D0.33568915
151PRKG10.33164266
152CSF1R0.32513358
153EPHA40.32002718
154GRK70.31265451
155CDK30.31055069
156AKT20.30883065
157MAP3K30.30654793
158PRKCD0.29908868
159MELK0.29619200
160KIT0.29330073
161MST1R0.29149391
162MST40.28280093
163MAPK40.28265332
164PRKCA0.28228379
165MKNK20.28070459
166PDK20.26018843
167SGK10.24852351
168PRKACB0.23583269
169SRC0.22277482
170MAPK10.21175753
171CSNK1A10.20513494
172PDGFRB0.18549025
173ADRBK10.17754013

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.98068274
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.45281693
3Nitrogen metabolism_Homo sapiens_hsa009102.74378470
4Mineral absorption_Homo sapiens_hsa049782.63733284
5Systemic lupus erythematosus_Homo sapiens_hsa053222.58426677
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.58214219
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52298603
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44394383
9Renin-angiotensin system_Homo sapiens_hsa046142.43589897
10Complement and coagulation cascades_Homo sapiens_hsa046102.31864603
11Caffeine metabolism_Homo sapiens_hsa002322.26778907
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24740971
13Arginine biosynthesis_Homo sapiens_hsa002202.20868922
14Fatty acid degradation_Homo sapiens_hsa000712.11343192
15DNA replication_Homo sapiens_hsa030302.11056019
16Tryptophan metabolism_Homo sapiens_hsa003802.06069380
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.04741995
18Vitamin B6 metabolism_Homo sapiens_hsa007502.01778448
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87131942
20Sulfur relay system_Homo sapiens_hsa041221.85004779
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84989641
22Selenocompound metabolism_Homo sapiens_hsa004501.83326972
23Protein digestion and absorption_Homo sapiens_hsa049741.77652033
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.75369578
25ABC transporters_Homo sapiens_hsa020101.74643094
26Peroxisome_Homo sapiens_hsa041461.70782142
27One carbon pool by folate_Homo sapiens_hsa006701.69194969
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65065128
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64007485
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63602513
31Folate biosynthesis_Homo sapiens_hsa007901.61039953
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.58594319
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.56485480
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50642750
35Pyruvate metabolism_Homo sapiens_hsa006201.46589548
36Propanoate metabolism_Homo sapiens_hsa006401.44559645
37Chemical carcinogenesis_Homo sapiens_hsa052041.42709626
38beta-Alanine metabolism_Homo sapiens_hsa004101.42702905
39PPAR signaling pathway_Homo sapiens_hsa033201.41994158
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40189513
41Pancreatic secretion_Homo sapiens_hsa049721.35180222
42Histidine metabolism_Homo sapiens_hsa003401.33638104
43Fatty acid metabolism_Homo sapiens_hsa012121.33446837
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29154522
45Galactose metabolism_Homo sapiens_hsa000521.27655567
46Butanoate metabolism_Homo sapiens_hsa006501.27226198
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.26830112
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25241871
49Bile secretion_Homo sapiens_hsa049761.24016158
50Staphylococcus aureus infection_Homo sapiens_hsa051501.23720954
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19288543
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18632405
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17277079
54Sulfur metabolism_Homo sapiens_hsa009201.16774138
55Biosynthesis of amino acids_Homo sapiens_hsa012301.09767233
56Phenylalanine metabolism_Homo sapiens_hsa003601.08221334
57Retinol metabolism_Homo sapiens_hsa008301.08165666
58Carbon metabolism_Homo sapiens_hsa012001.06469264
59Ribosome_Homo sapiens_hsa030101.01108579
60Tyrosine metabolism_Homo sapiens_hsa003500.98548002
61Fat digestion and absorption_Homo sapiens_hsa049750.97931034
62Pyrimidine metabolism_Homo sapiens_hsa002400.97477211
63Mismatch repair_Homo sapiens_hsa034300.96791541
64Glutathione metabolism_Homo sapiens_hsa004800.94680881
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93739955
66Arachidonic acid metabolism_Homo sapiens_hsa005900.92095761
67Pentose phosphate pathway_Homo sapiens_hsa000300.87787743
68Alcoholism_Homo sapiens_hsa050340.86113226
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84941752
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.84889599
71Fatty acid elongation_Homo sapiens_hsa000620.83836975
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83103687
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81628188
74Starch and sucrose metabolism_Homo sapiens_hsa005000.79485498
75Base excision repair_Homo sapiens_hsa034100.78056660
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75290448
77Arginine and proline metabolism_Homo sapiens_hsa003300.73829365
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.71768115
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.69802435
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69610054
81Proteasome_Homo sapiens_hsa030500.68593597
82Nucleotide excision repair_Homo sapiens_hsa034200.68018000
83Cell cycle_Homo sapiens_hsa041100.67207440
84Sphingolipid metabolism_Homo sapiens_hsa006000.66949912
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.65693871
86Metabolic pathways_Homo sapiens_hsa011000.64926189
87Lysine degradation_Homo sapiens_hsa003100.63430811
88Vitamin digestion and absorption_Homo sapiens_hsa049770.63291358
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62453809
90Homologous recombination_Homo sapiens_hsa034400.51017496
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50509052
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49927329
93Ether lipid metabolism_Homo sapiens_hsa005650.49442447
94Renin secretion_Homo sapiens_hsa049240.48182962
95Hematopoietic cell lineage_Homo sapiens_hsa046400.46937320
96Tight junction_Homo sapiens_hsa045300.45954636
97Steroid biosynthesis_Homo sapiens_hsa001000.45329888
98Fructose and mannose metabolism_Homo sapiens_hsa000510.43324336
99Parkinsons disease_Homo sapiens_hsa050120.42102897
100Thyroid hormone synthesis_Homo sapiens_hsa049180.41231518
101Viral carcinogenesis_Homo sapiens_hsa052030.40546238
102Malaria_Homo sapiens_hsa051440.40325566
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.39382620
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37174198
105Non-homologous end-joining_Homo sapiens_hsa034500.36655249
106p53 signaling pathway_Homo sapiens_hsa041150.33717638
107Vibrio cholerae infection_Homo sapiens_hsa051100.32672335
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31994704
109Long-term depression_Homo sapiens_hsa047300.31212891
110Fanconi anemia pathway_Homo sapiens_hsa034600.29726606
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29706911
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29424123
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28754757
114Linoleic acid metabolism_Homo sapiens_hsa005910.28666804
115Fatty acid biosynthesis_Homo sapiens_hsa000610.27716697
116Purine metabolism_Homo sapiens_hsa002300.27511722
117Adherens junction_Homo sapiens_hsa045200.26968835
118Spliceosome_Homo sapiens_hsa030400.26867682
119Dorso-ventral axis formation_Homo sapiens_hsa043200.24902663
120Axon guidance_Homo sapiens_hsa043600.24326140
121Salivary secretion_Homo sapiens_hsa049700.24164740
122Glycerolipid metabolism_Homo sapiens_hsa005610.23627415
123Olfactory transduction_Homo sapiens_hsa047400.23306251
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20454168
125Herpes simplex infection_Homo sapiens_hsa051680.19410123
126Taste transduction_Homo sapiens_hsa047420.19367909
127RNA transport_Homo sapiens_hsa030130.19169867
128Oxidative phosphorylation_Homo sapiens_hsa001900.17978444
129Notch signaling pathway_Homo sapiens_hsa043300.17842350
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17675793
131RNA polymerase_Homo sapiens_hsa030200.17222653
132Choline metabolism in cancer_Homo sapiens_hsa052310.16913420
133Serotonergic synapse_Homo sapiens_hsa047260.16792826
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16463014
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.13966871
136Rheumatoid arthritis_Homo sapiens_hsa053230.12099008
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.11158241
138Huntingtons disease_Homo sapiens_hsa050160.11073353
139Gastric acid secretion_Homo sapiens_hsa049710.09903292
140African trypanosomiasis_Homo sapiens_hsa051430.08221001
141Hepatitis C_Homo sapiens_hsa051600.07913274
142Insulin resistance_Homo sapiens_hsa049310.07412817
143Insulin secretion_Homo sapiens_hsa049110.06053171
144Amphetamine addiction_Homo sapiens_hsa050310.05647786
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.04317819
146Ovarian steroidogenesis_Homo sapiens_hsa049130.02223330
147ECM-receptor interaction_Homo sapiens_hsa045120.02076418
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.01944810
149Cocaine addiction_Homo sapiens_hsa050300.00102467
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0063845

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