NXPE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.02628109
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.33799854
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.33799854
4antigen processing and presentation of endogenous antigen (GO:0019883)6.23053672
5regulation of gamma-delta T cell differentiation (GO:0045586)5.75048971
6negative T cell selection (GO:0043383)5.73012115
7negative thymic T cell selection (GO:0045060)5.70892817
8muscle filament sliding (GO:0030049)5.32958305
9actin-myosin filament sliding (GO:0033275)5.32958305
10positive thymic T cell selection (GO:0045059)5.28892159
11regulation of skeletal muscle contraction (GO:0014819)5.20066356
12response to interleukin-15 (GO:0070672)5.19986413
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.17897589
14negative regulation of cell killing (GO:0031342)5.17897589
15thymic T cell selection (GO:0045061)5.11426716
16regulation of gamma-delta T cell activation (GO:0046643)5.04092246
17T cell selection (GO:0045058)4.90628580
18positive T cell selection (GO:0043368)4.89818584
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.89077149
20sarcoplasmic reticulum calcium ion transport (GO:0070296)4.77057706
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.65587706
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.62754780
23B cell receptor signaling pathway (GO:0050853)4.59420405
24cellular response to interleukin-15 (GO:0071350)4.55016265
25actin-mediated cell contraction (GO:0070252)4.39274577
26regulation of relaxation of muscle (GO:1901077)4.31718451
27T cell receptor signaling pathway (GO:0050852)4.20442029
28regulation of isotype switching to IgG isotypes (GO:0048302)4.19887901
29positive regulation of B cell differentiation (GO:0045579)4.19714139
30T cell costimulation (GO:0031295)4.16696807
31lymphocyte costimulation (GO:0031294)4.13339833
32tolerance induction (GO:0002507)4.12347776
33antigen receptor-mediated signaling pathway (GO:0050851)4.11937674
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.07331930
35response to inactivity (GO:0014854)4.07006899
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.03424969
37skeletal muscle contraction (GO:0003009)4.02560903
38interferon-gamma production (GO:0032609)4.01859998
39regulation of B cell differentiation (GO:0045577)4.00950899
40T cell migration (GO:0072678)4.00347006
41myofibril assembly (GO:0030239)3.95091337
42behavioral response to nicotine (GO:0035095)3.94438590
43regulation of regulatory T cell differentiation (GO:0045589)3.90042544
44leukocyte aggregation (GO:0070486)3.88171000
45regulation of memory T cell differentiation (GO:0043380)3.87040193
46positive regulation of interleukin-2 production (GO:0032743)3.79111250
47regulation of T cell tolerance induction (GO:0002664)3.75228321
48neuronal action potential propagation (GO:0019227)3.71765134
49T cell homeostasis (GO:0043029)3.68671587
50regulation of B cell receptor signaling pathway (GO:0050855)3.67923417
51antigen processing and presentation via MHC class Ib (GO:0002475)3.62795365
52mast cell activation involved in immune response (GO:0002279)3.59257877
53mast cell degranulation (GO:0043303)3.59257877
54mast cell activation (GO:0045576)3.51068543
55regulation of interleukin-2 biosynthetic process (GO:0045076)3.49798130
56natural killer cell differentiation (GO:0001779)3.40655299
57sarcomere organization (GO:0045214)3.39344112
58striated muscle contraction (GO:0006941)3.37872919
59response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.37110626
60negative regulation of erythrocyte differentiation (GO:0045647)3.37047831
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36406286
62membrane depolarization during action potential (GO:0086010)3.35273034
63activated T cell proliferation (GO:0050798)3.33843654
64regulation of cell communication by electrical coupling (GO:0010649)3.33822582
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28240895
66neuromuscular synaptic transmission (GO:0007274)3.23237314
67regulation of T cell receptor signaling pathway (GO:0050856)3.22680505
68immune response-activating cell surface receptor signaling pathway (GO:0002429)3.22142350
69positive regulation of tolerance induction (GO:0002645)3.20906684
70actin filament-based movement (GO:0030048)3.19920181
71skeletal muscle adaptation (GO:0043501)3.16208301
72regulation of alpha-beta T cell proliferation (GO:0046640)3.14961198
73Peyers patch development (GO:0048541)3.14285060
74mucosal-associated lymphoid tissue development (GO:0048537)3.14285060
75regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.14195486
76interkinetic nuclear migration (GO:0022027)3.13800257
77JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.13488284
78positive regulation of histone deacetylation (GO:0031065)3.12232148
79regulation of sarcomere organization (GO:0060297)3.11931142
80regulation of ARF protein signal transduction (GO:0032012)3.11130229
81regulation of defense response to virus by virus (GO:0050690)3.11070954
82lymphocyte homeostasis (GO:0002260)3.09490234
83mannose metabolic process (GO:0006013)3.09269384
84negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08823539
85relaxation of cardiac muscle (GO:0055119)3.05951202
86regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00379565
87positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.97961951
88relaxation of muscle (GO:0090075)2.97422683
89plasma membrane repair (GO:0001778)2.96116623
90positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.95950238
91negative regulation of phagocytosis (GO:0050765)2.95931371
92muscle fiber development (GO:0048747)2.92629735
93gamma-aminobutyric acid transport (GO:0015812)2.91091800
94cardiac myofibril assembly (GO:0055003)2.88860452
95skeletal muscle fiber development (GO:0048741)2.87430203
96response to muscle activity (GO:0014850)2.86555463
97positive regulation of Rap GTPase activity (GO:0032854)2.86007197
98regulation of interleukin-12 biosynthetic process (GO:0045075)2.86001265
99cAMP catabolic process (GO:0006198)2.84311903
100positive regulation of natural killer cell mediated immunity (GO:0002717)2.84020971
101positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.84020971
102regulation of striated muscle contraction (GO:0006942)2.84014242
103protein K63-linked deubiquitination (GO:0070536)2.83773847
104regulation of natural killer cell mediated immunity (GO:0002715)2.83537785
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83537785
106regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82733488
107positive regulation of defense response to virus by host (GO:0002230)2.82096479
108negative regulation of B cell mediated immunity (GO:0002713)2.80840496
109negative regulation of immunoglobulin mediated immune response (GO:0002890)2.80840496
110myotube cell development (GO:0014904)2.80560067
111regulation of isotype switching (GO:0045191)2.76544485
112cyclic nucleotide catabolic process (GO:0009214)2.76535550
113positive regulation of myoblast differentiation (GO:0045663)2.76358818
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76001350
115regulation of calcium ion transmembrane transporter activity (GO:1901019)2.75600875
116regulation of calcium ion transmembrane transport (GO:1903169)2.75600875
117muscle contraction (GO:0006936)2.75510940
118growth hormone receptor signaling pathway (GO:0060396)2.75031458
119regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.74353472
120negative regulation of lymphocyte mediated immunity (GO:0002707)2.74321210
121regulation of interleukin-2 production (GO:0032663)2.74112312
122regulation of tolerance induction (GO:0002643)2.73094118
123negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72202643
124positive regulation of granulocyte differentiation (GO:0030854)2.71623251
125hepatocyte apoptotic process (GO:0097284)2.71198347
126striated muscle atrophy (GO:0014891)2.71073930
127regulation of histone H3-K27 methylation (GO:0061085)2.70496211
128positive regulation of interleukin-17 production (GO:0032740)2.70413511
129negative regulation of T-helper cell differentiation (GO:0045623)2.67896012
130negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.67896012
131regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.67299512
132natural killer cell activation (GO:0030101)2.65129782
133proline transport (GO:0015824)2.65126934
134protein K11-linked deubiquitination (GO:0035871)2.64957897
135muscle system process (GO:0003012)2.64595743
136positive regulation of T cell differentiation (GO:0045582)2.63990519
137positive regulation of alpha-beta T cell proliferation (GO:0046641)2.63920506
138leukocyte homeostasis (GO:0001776)2.63267722
139cytoplasmic mRNA processing body assembly (GO:0033962)2.63137829
140negative regulation of T cell mediated immunity (GO:0002710)2.63132274
141regulation of immunoglobulin production (GO:0002637)2.62948828
142regulation of actin filament-based movement (GO:1903115)2.62144593
143leukocyte cell-cell adhesion (GO:0007159)2.61384355
144regulation of B cell proliferation (GO:0030888)2.60889146
145cardiac muscle contraction (GO:0060048)2.59906218
146fucose catabolic process (GO:0019317)2.58806290
147L-fucose metabolic process (GO:0042354)2.58806290
148L-fucose catabolic process (GO:0042355)2.58806290
149T cell proliferation (GO:0042098)2.58694653
150gamma-aminobutyric acid signaling pathway (GO:0007214)2.58399105
151negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.57712883
152positive regulation of interleukin-4 production (GO:0032753)2.56687787
153positive regulation of cation channel activity (GO:2001259)2.56238499
154neuronal action potential (GO:0019228)2.55185153
155actomyosin structure organization (GO:0031032)2.54531905
156regulation of energy homeostasis (GO:2000505)2.53644816
157regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.53330067
158potassium ion import (GO:0010107)2.52800824
159skeletal muscle tissue development (GO:0007519)2.51582464
160regulation of alpha-beta T cell activation (GO:0046634)2.51446218
161positive regulation of isotype switching (GO:0045830)2.51073216
162detection of light stimulus involved in visual perception (GO:0050908)2.50090913
163detection of light stimulus involved in sensory perception (GO:0050962)2.50090913
164phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.49826017
165B cell proliferation (GO:0042100)2.49502855
166regulation of Rap GTPase activity (GO:0032317)2.49414327
167positive regulation of T cell activation (GO:0050870)2.48739290
168sodium ion export (GO:0071436)2.48641844
169regulation of sequestering of triglyceride (GO:0010889)2.48403244
170B cell homeostasis (GO:0001782)2.48329387
171positive regulation of immunoglobulin production (GO:0002639)2.47576350
172cellular response to growth hormone stimulus (GO:0071378)2.47110239
173regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.46899581
174response to caffeine (GO:0031000)2.46666106
175DNA deamination (GO:0045006)2.45277970
176striated muscle adaptation (GO:0014888)2.43687487
177cardiac muscle hypertrophy (GO:0003300)2.41613548
178regulation of membrane repolarization (GO:0060306)2.40763970
179auditory receptor cell stereocilium organization (GO:0060088)2.40589525
180establishment of protein localization to Golgi (GO:0072600)2.40407834
181positive regulation of cell fate commitment (GO:0010455)2.38046475
182synaptic transmission, cholinergic (GO:0007271)2.37584319
183adult heart development (GO:0007512)2.37511378
184negative regulation of mast cell activation (GO:0033004)2.37235800
185cytidine deamination (GO:0009972)2.36163752
186cytidine metabolic process (GO:0046087)2.36163752
187cytidine catabolic process (GO:0006216)2.36163752
188pyrimidine ribonucleoside catabolic process (GO:0046133)2.32601068
189muscle atrophy (GO:0014889)2.31034337
190regulation of voltage-gated calcium channel activity (GO:1901385)2.30753000
191negative regulation of muscle contraction (GO:0045932)2.29585292
192regulation of translation, ncRNA-mediated (GO:0045974)2.28948858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.21831509
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.70380502
3MYC_22102868_ChIP-Seq_BL_Human4.64592414
4RUNX_20019798_ChIP-Seq_JUKART_Human3.77296618
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.59929544
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.48932242
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.39688515
8GBX2_23144817_ChIP-Seq_PC3_Human3.37562090
9MYB_26560356_Chip-Seq_TH2_Human3.22738491
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19040891
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.16952603
12MAF_26560356_Chip-Seq_TH1_Human2.92164145
13UTX_26944678_Chip-Seq_JUKART_Human2.77565765
14MYB_26560356_Chip-Seq_TH1_Human2.75768382
15VDR_21846776_ChIP-Seq_THP-1_Human2.72053957
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63817054
17E2F7_22180533_ChIP-Seq_HELA_Human2.60660113
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58529737
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.55021310
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.55012452
21IGF1R_20145208_ChIP-Seq_DFB_Human2.52905273
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47492176
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39234705
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38113494
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.36961327
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36854041
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31161141
28ZNF274_21170338_ChIP-Seq_K562_Hela2.31115348
29VDR_22108803_ChIP-Seq_LS180_Human2.29171665
30TCF7_22412390_ChIP-Seq_EML_Mouse2.27615947
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26553044
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18543156
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18414604
34KDM2B_26808549_Chip-Seq_DND41_Human2.17669397
35FLI1_27457419_Chip-Seq_LIVER_Mouse2.15082797
36EGR1_19374776_ChIP-ChIP_THP-1_Human2.08504588
37RUNX1_22412390_ChIP-Seq_EML_Mouse2.06282729
38KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00615280
39POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00470849
40MAF_26560356_Chip-Seq_TH2_Human2.00237593
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97879845
42GATA3_27048872_Chip-Seq_THYMUS_Human1.97696422
43VDR_24763502_ChIP-Seq_THP-1_Human1.97409858
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95602634
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93563985
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91003304
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90266443
48TAF15_26573619_Chip-Seq_HEK293_Human1.85342289
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84328648
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81474647
51ER_23166858_ChIP-Seq_MCF-7_Human1.80591339
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80531166
53SCL_19346495_ChIP-Seq_HPC-7_Human1.77032836
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.75171524
55CIITA_25753668_ChIP-Seq_RAJI_Human1.73105058
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71496971
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68637652
58SPI1_23127762_ChIP-Seq_K562_Human1.68419298
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64817650
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64436890
61SMAD4_21799915_ChIP-Seq_A2780_Human1.60731839
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59437171
63P300_19829295_ChIP-Seq_ESCs_Human1.58765316
64STAT3_23295773_ChIP-Seq_U87_Human1.56640726
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56634699
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.54167949
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50533089
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46532789
69TCF4_23295773_ChIP-Seq_U87_Human1.46462788
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46450610
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.46388435
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.45566005
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.45231434
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44045228
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42880192
76* SPI1_23547873_ChIP-Seq_NB4_Human1.41872081
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40118742
78FUS_26573619_Chip-Seq_HEK293_Human1.37996418
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37825478
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36166740
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.35743382
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.35104772
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.35030200
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34863393
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34722533
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.33407687
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32490662
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31572223
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31425557
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30278189
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30086476
92BCAT_22108803_ChIP-Seq_LS180_Human1.28616559
93EWS_26573619_Chip-Seq_HEK293_Human1.28551288
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28468683
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25868142
96REST_21632747_ChIP-Seq_MESCs_Mouse1.24912800
97TP53_16413492_ChIP-PET_HCT116_Human1.23171456
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.22957735
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22558186
100AR_25329375_ChIP-Seq_VCAP_Human1.21692632
101KDM2B_26808549_Chip-Seq_REH_Human1.21520991
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.21063973
103CBP_20019798_ChIP-Seq_JUKART_Human1.19528574
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19528574
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19310660
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.18401362
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18216537
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.17683451
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16047639
110JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15747537
111GATA3_26560356_Chip-Seq_TH2_Human1.15409239
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.15191974
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14746858
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14314755
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14257532
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14088565
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13812340
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13190619
119NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13190619
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13105019
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13103869
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.13089111
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12147187
124P53_22387025_ChIP-Seq_ESCs_Mouse1.11546634
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11023453
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10890088
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10890088
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10799364
129GATA1_19941827_ChIP-Seq_MEL_Mouse1.10365814
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10157988
131RARB_27405468_Chip-Seq_BRAIN_Mouse1.09496180
132EZH2_22144423_ChIP-Seq_EOC_Human1.09463067
133EP300_21415370_ChIP-Seq_HL-1_Mouse1.09041984
134SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08888415
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08116416
136TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07409871
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05877955
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05149743
139VDR_24787735_ChIP-Seq_THP-1_Human1.05094868
140PU_27001747_Chip-Seq_BMDM_Mouse1.04580747
141RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04164672
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04054793
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02847427
144E2F1_18555785_Chip-Seq_ESCs_Mouse1.02157551
145PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02053374
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01793968
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00885580
148RUNX2_22187159_ChIP-Seq_PCA_Human1.00830196
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.00479248
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.99751950
151ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99672346
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.98530884
153GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97754578
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.95087405
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94755379
156PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94723733
157DROSHA_22980978_ChIP-Seq_HELA_Human0.94594886
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93946440
159SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.92241662
160GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.92150163
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91868340
162NANOG_19829295_ChIP-Seq_ESCs_Human0.91390190
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90523951
164NCOR1_26117541_ChIP-Seq_K562_Human0.89943614
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89005626
166CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87252424
167ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87142748
168NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85958132
169EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85553592
170SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84944479
171FOXM1_23109430_ChIP-Seq_U2OS_Human0.84458649
172DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84150825
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.83611198
174RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82478921
175GATA3_26560356_Chip-Seq_TH1_Human0.81344952
176GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81096111
177LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81069791
178SMRT_27268052_Chip-Seq_Bcells_Human0.78489301
179AR_21572438_ChIP-Seq_LNCaP_Human0.75905518
180GATA2_19941826_ChIP-Seq_K562_Human0.75250305
181TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74875251
182LXR_22292898_ChIP-Seq_THP-1_Human0.74314852
183ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74052487
184KDM5A_27292631_Chip-Seq_BREAST_Human0.71531427
185FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70433866
186CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69508033
187DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.69494118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.58900935
2MP0004145_abnormal_muscle_electrophysio5.10142699
3MP0003763_abnormal_thymus_physiology3.97950782
4MP0000749_muscle_degeneration3.59597165
5MP0004130_abnormal_muscle_cell3.54413475
6MP0004036_abnormal_muscle_relaxation3.20957989
7MP0003300_gastrointestinal_ulcer3.20505667
8MP0000685_abnormal_immune_system3.15790199
9MP0005310_abnormal_salivary_gland3.13171657
10MP0005671_abnormal_response_to3.12878896
11MP0000751_myopathy3.11536857
12MP0001800_abnormal_humoral_immune3.10758511
13MP0001835_abnormal_antigen_presentation3.10757401
14MP0001873_stomach_inflammation3.10001983
15MP0001790_abnormal_immune_system3.01683285
16MP0005387_immune_system_phenotype3.01683285
17MP0002166_altered_tumor_susceptibility2.93221556
18MP0004084_abnormal_cardiac_muscle2.65866320
19MP0002396_abnormal_hematopoietic_system2.62782331
20MP0002398_abnormal_bone_marrow2.60383663
21MP0003866_abnormal_defecation2.42803400
22MP0002420_abnormal_adaptive_immunity2.40729715
23MP0002106_abnormal_muscle_physiology2.38787974
24MP0005000_abnormal_immune_tolerance2.36944184
25MP0002723_abnormal_immune_serum2.36765494
26MP0001819_abnormal_immune_cell2.35121045
27MP0002452_abnormal_antigen_presenting2.34770290
28MP0002332_abnormal_exercise_endurance2.33953615
29MP0002006_tumorigenesis2.33656299
30MP0002837_dystrophic_cardiac_calcinosis2.27984808
31MP0005620_abnormal_muscle_contractility2.27955054
32MP0000716_abnormal_immune_system2.19833492
33MP0000703_abnormal_thymus_morphology2.19447526
34MP0000747_muscle_weakness2.12475346
35MP0004859_abnormal_synaptic_plasticity2.07316591
36MP0004484_altered_response_of2.03142694
37MP0005369_muscle_phenotype1.99209874
38MP0000689_abnormal_spleen_morphology1.98454552
39MP0002722_abnormal_immune_system1.97881852
40MP0004808_abnormal_hematopoietic_stem1.97301054
41MP0004087_abnormal_muscle_fiber1.97158469
42MP0004215_abnormal_myocardial_fiber1.91131775
43MP0000759_abnormal_skeletal_muscle1.89694073
44MP0004270_analgesia1.89527837
45MP0003303_peritoneal_inflammation1.80967486
46MP0010155_abnormal_intestine_physiology1.80750411
47MP0002269_muscular_atrophy1.80455260
48MP0002429_abnormal_blood_cell1.77365952
49MP0004142_abnormal_muscle_tone1.69494418
50MP0003183_abnormal_peptide_metabolism1.68058759
51MP0002405_respiratory_system_inflammati1.67430577
52MP0008961_abnormal_basal_metabolism1.65725292
53MP0005025_abnormal_response_to1.64936121
54MP0009333_abnormal_splenocyte_physiolog1.64075450
55MP0010234_abnormal_vibrissa_follicle1.62254903
56MP0005464_abnormal_platelet_physiology1.51885066
57MP0002972_abnormal_cardiac_muscle1.48096028
58MP0001348_abnormal_lacrimal_gland1.45245675
59MP0008569_lethality_at_weaning1.41975975
60MP0004885_abnormal_endolymph1.39866126
61MP0001968_abnormal_touch/_nociception1.39024753
62MP0002735_abnormal_chemical_nociception1.38027264
63MP0005410_abnormal_fertilization1.37447053
64MP0000013_abnormal_adipose_tissue1.35821668
65MP0002638_abnormal_pupillary_reflex1.35294551
66MP0001845_abnormal_inflammatory_respons1.33396405
67MP0010386_abnormal_urinary_bladder1.32193388
68MP0003436_decreased_susceptibility_to1.30763453
69MP0000750_abnormal_muscle_regeneration1.27007680
70MP0004510_myositis1.26131608
71MP0001486_abnormal_startle_reflex1.23398769
72MP0003635_abnormal_synaptic_transmissio1.22422920
73MP0002736_abnormal_nociception_after1.22167185
74MP0009785_altered_susceptibility_to1.21258319
75MP0002127_abnormal_cardiovascular_syste1.19305311
76MP0004947_skin_inflammation1.17872686
77MP0006082_CNS_inflammation1.17547716
78MP0001765_abnormal_ion_homeostasis1.16965352
79MP0002419_abnormal_innate_immunity1.14392297
80MP0004233_abnormal_muscle_weight1.13411647
81MP0003724_increased_susceptibility_to1.12294681
82MP0002734_abnormal_mechanical_nocicepti1.11463211
83MP0002148_abnormal_hypersensitivity_rea1.10278829
84MP0000733_abnormal_muscle_development1.09618757
85MP0005174_abnormal_tail_pigmentation1.09452508
86MP0003787_abnormal_imprinting1.09265395
87MP0002009_preneoplasia1.09235864
88MP0004043_abnormal_pH_regulation1.08908982
89MP0002108_abnormal_muscle_morphology1.08202196
90MP0005551_abnormal_eye_electrophysiolog1.06205851
91MP0005386_behavior/neurological_phenoty1.02119928
92MP0004924_abnormal_behavior1.02119928
93MP0005330_cardiomyopathy1.01897100
94MP0010352_gastrointestinal_tract_polyps1.01065457
95MP0005266_abnormal_metabolism0.98300835
96MP0005385_cardiovascular_system_phenoty0.97194819
97MP0001544_abnormal_cardiovascular_syste0.97194819
98MP0000465_gastrointestinal_hemorrhage0.96403760
99MP0003045_fibrosis0.95530175
100MP0008874_decreased_physiological_sensi0.92079025
101MP0004134_abnormal_chest_morphology0.91557940
102MP0003828_pulmonary_edema0.91358274
103MP0002064_seizures0.91337349
104MP0009745_abnormal_behavioral_response0.88676245
105MP0008775_abnormal_heart_ventricle0.88564576
106MP0002876_abnormal_thyroid_physiology0.86354767
107MP0003950_abnormal_plasma_membrane0.84258959
108MP0001970_abnormal_pain_threshold0.83970112
109MP0004085_abnormal_heartbeat0.83372178
110MP0000569_abnormal_digit_pigmentation0.82764758
111MP0000230_abnormal_systemic_arterial0.82711293
112MP0000490_abnormal_crypts_of0.82476588
113MP0001984_abnormal_olfaction0.82218808
114MP0002019_abnormal_tumor_incidence0.81243754
115MP0005423_abnormal_somatic_nervous0.80685262
116MP0001440_abnormal_grooming_behavior0.80344530
117MP0001663_abnormal_digestive_system0.80331776
118MP0002733_abnormal_thermal_nociception0.78919156
119MP0002136_abnormal_kidney_physiology0.78588492
120MP0006276_abnormal_autonomic_nervous0.78298859
121MP0005253_abnormal_eye_physiology0.78187067
122MP0003329_amyloid_beta_deposits0.77455500
123MP0001853_heart_inflammation0.77258143
124MP0001661_extended_life_span0.75808539
125MP0002909_abnormal_adrenal_gland0.74254457
126MP0003137_abnormal_impulse_conducting0.73353881
127MP0001986_abnormal_taste_sensitivity0.71205092
128MP0009278_abnormal_bone_marrow0.70941429
129MP0000920_abnormal_myelination0.70887733
130MP0009046_muscle_twitch0.70178378
131MP0005397_hematopoietic_system_phenotyp0.68908669
132MP0001545_abnormal_hematopoietic_system0.68908669
133MP0002063_abnormal_learning/memory/cond0.68522676
134MP0002066_abnormal_motor_capabilities/c0.68290660
135MP0002083_premature_death0.68067396
136MP0005166_decreased_susceptibility_to0.67610153
137MP0010630_abnormal_cardiac_muscle0.67454557
138MP0003221_abnormal_cardiomyocyte_apopto0.67401202
139MP0002822_catalepsy0.66379303
140MP0003172_abnormal_lysosome_physiology0.64470515
141MP0005647_abnormal_sex_gland0.64406516
142MP0000427_abnormal_hair_cycle0.64035082
143MP0003880_abnormal_central_pattern0.63934877
144MP0005645_abnormal_hypothalamus_physiol0.63870729
145MP0002272_abnormal_nervous_system0.63569350
146MP0009765_abnormal_xenobiotic_induced0.62706876
147MP0004742_abnormal_vestibular_system0.62446563
148MP0001501_abnormal_sleep_pattern0.62317277
149MP0002933_joint_inflammation0.62160674
150MP0008872_abnormal_physiological_respon0.61794640
151MP0004811_abnormal_neuron_physiology0.61701456
152MP0002067_abnormal_sensory_capabilities0.61662961
153MP0002234_abnormal_pharynx_morphology0.61628069
154MP0008877_abnormal_DNA_methylation0.61571368
155MP0008057_abnormal_DNA_replication0.61114138
156MP0002572_abnormal_emotion/affect_behav0.60909106
157MP0001485_abnormal_pinna_reflex0.60829414
158MP0002184_abnormal_innervation0.60733836
159MP0000604_amyloidosis0.60651093
160MP0009764_decreased_sensitivity_to0.59200234
161MP0006138_congestive_heart_failure0.58059594
162MP0002229_neurodegeneration0.57784945
163MP0001502_abnormal_circadian_rhythm0.57218095
164MP0003656_abnormal_erythrocyte_physiolo0.56016869
165MP0006072_abnormal_retinal_apoptosis0.55849171
166MP0003633_abnormal_nervous_system0.55139578
167MP0008770_decreased_survivor_rate0.55047035

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.92536648
2Nemaline bodies (HP:0003798)7.81176355
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.62688789
4Type 1 muscle fiber predominance (HP:0003803)5.71190281
5Agammaglobulinemia (HP:0004432)5.50368268
6Recurrent bronchitis (HP:0002837)5.35205044
7Muscle hypertrophy of the lower extremities (HP:0008968)5.01963931
8Chronic otitis media (HP:0000389)4.98340601
9Exercise-induced myalgia (HP:0003738)4.89060578
10Calf muscle hypertrophy (HP:0008981)4.76434601
11Exercise-induced muscle cramps (HP:0003710)4.76165954
12T lymphocytopenia (HP:0005403)4.66379656
13Panhypogammaglobulinemia (HP:0003139)4.59276836
14Recurrent viral infections (HP:0004429)4.44336012
15Abnormality of T cell number (HP:0011839)4.43853303
16IgM deficiency (HP:0002850)4.41781381
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.30964546
18Nasal polyposis (HP:0100582)4.25477487
19Distal arthrogryposis (HP:0005684)4.22010997
20Recurrent fungal infections (HP:0002841)3.92206764
21Recurrent cutaneous fungal infections (HP:0011370)3.91891473
22Chronic mucocutaneous candidiasis (HP:0002728)3.91891473
23Hyporeflexia of lower limbs (HP:0002600)3.91197627
24EMG: myopathic abnormalities (HP:0003458)3.88091334
25Verrucae (HP:0200043)3.85050778
26Papilloma (HP:0012740)3.85050778
27Abnormality of T cells (HP:0002843)3.74513087
28Cellulitis (HP:0100658)3.61813930
29Recurrent sinusitis (HP:0011108)3.57455224
30Abnormality of B cell number (HP:0010975)3.52198759
31B lymphocytopenia (HP:0010976)3.52198759
32Abnormality of the calf musculature (HP:0001430)3.50547186
33Abnormality of the nasal mucosa (HP:0000433)3.43503772
34Inflammation of the large intestine (HP:0002037)3.41506299
35Gastrointestinal inflammation (HP:0004386)3.39533070
36Areflexia of lower limbs (HP:0002522)3.39269585
37IgG deficiency (HP:0004315)3.38441510
38Muscle fiber splitting (HP:0003555)3.31739552
39Chronic sinusitis (HP:0011109)3.30876825
40Abnormality of the left ventricular outflow tract (HP:0011103)3.29880202
41Subaortic stenosis (HP:0001682)3.29880202
42Bundle branch block (HP:0011710)3.29336046
43Meningitis (HP:0001287)3.29143057
44Rimmed vacuoles (HP:0003805)3.24917158
45Neck muscle weakness (HP:0000467)3.24899085
46IgA deficiency (HP:0002720)3.24104048
47Abnormality of the fingertips (HP:0001211)3.22866466
48Gastrointestinal stroma tumor (HP:0100723)3.20918324
49Bronchitis (HP:0012387)3.20525118
50Abnormality of T cell physiology (HP:0011840)3.20283563
51Papilledema (HP:0001085)3.16896414
52Difficulty running (HP:0009046)3.15365557
53Myopathic facies (HP:0002058)3.09833830
54Lymphopenia (HP:0001888)3.05343183
55Round ear (HP:0100830)2.98478730
56Genetic anticipation (HP:0003743)2.97565923
57Frequent falls (HP:0002359)2.95584264
58Myotonia (HP:0002486)2.92936774
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.91550804
60Colitis (HP:0002583)2.90851353
61Febrile seizures (HP:0002373)2.84352934
62Absent phalangeal crease (HP:0006109)2.81540637
63Thyroiditis (HP:0100646)2.79391429
64Clumsiness (HP:0002312)2.79241215
65Recurrent otitis media (HP:0000403)2.72450180
66Facial diplegia (HP:0001349)2.70089461
67Progressive cerebellar ataxia (HP:0002073)2.68550827
68Stomatitis (HP:0010280)2.67744483
69Congenital stationary night blindness (HP:0007642)2.66981206
70Ulnar deviation of the wrist (HP:0003049)2.66146397
71Severe combined immunodeficiency (HP:0004430)2.60576593
72Gaze-evoked nystagmus (HP:0000640)2.59464410
73Myoglobinuria (HP:0002913)2.55372532
74Abnormal finger flexion creases (HP:0006143)2.54352464
75Hyperventilation (HP:0002883)2.53311881
76Chronic diarrhea (HP:0002028)2.51342551
77Sudden death (HP:0001699)2.51176206
78Elevated erythrocyte sedimentation rate (HP:0003565)2.49340972
79Thrombocytosis (HP:0001894)2.46859739
80Vasculitis (HP:0002633)2.41035624
81Asymmetric septal hypertrophy (HP:0001670)2.40386458
82Abnormality of skeletal muscle fiber size (HP:0012084)2.40185836
83Emphysema (HP:0002097)2.39156474
84Stomach cancer (HP:0012126)2.38122143
85EMG: neuropathic changes (HP:0003445)2.37858406
86Pustule (HP:0200039)2.37627141
87Basal cell carcinoma (HP:0002671)2.36859811
88Broad-based gait (HP:0002136)2.36804236
89Hyperkalemia (HP:0002153)2.36657781
90Combined immunodeficiency (HP:0005387)2.32947580
91Focal seizures (HP:0007359)2.31936831
92Dialeptic seizures (HP:0011146)2.30447345
93Inability to walk (HP:0002540)2.30314023
94Atonic seizures (HP:0010819)2.29105755
95Myositis (HP:0100614)2.28961960
96Progressive inability to walk (HP:0002505)2.20914286
97Abnormality of the neuromuscular junction (HP:0003398)2.20217274
98Fatigable weakness (HP:0003473)2.20217274
99Centrally nucleated skeletal muscle fibers (HP:0003687)2.19302967
100Absence seizures (HP:0002121)2.17578436
101Rhabdomyolysis (HP:0003201)2.15751859
102Hyperacusis (HP:0010780)2.14468138
103Increased density of long bones (HP:0006392)2.13724920
104Eczematoid dermatitis (HP:0000976)2.13420475
105Fetal akinesia sequence (HP:0001989)2.12961612
106Eosinophilia (HP:0001880)2.09749835
107Recurrent skin infections (HP:0001581)2.09599184
108Encephalitis (HP:0002383)2.08664389
109Generalized muscle weakness (HP:0003324)2.07341541
110Chronic obstructive pulmonary disease (HP:0006510)2.07327026
111Obstructive lung disease (HP:0006536)2.07327026
112Large for gestational age (HP:0001520)2.07193548
113Bronchiectasis (HP:0002110)2.05505630
114Increased IgE level (HP:0003212)2.04095583
115Autoimmune hemolytic anemia (HP:0001890)2.02649454
116Abnormality of oral frenula (HP:0000190)2.02421107
117Focal motor seizures (HP:0011153)2.02386165
118Absent speech (HP:0001344)2.01952171
119Decreased subcutaneous fat (HP:0001002)2.01773101
120Abnormality of cochlea (HP:0000375)2.01582364
121Hemiplegia (HP:0002301)2.00527324
122Aortic aneurysm (HP:0004942)2.00226529
123Viral hepatitis (HP:0006562)1.97865379
124Increased variability in muscle fiber diameter (HP:0003557)1.96343003
125Nonprogressive disorder (HP:0003680)1.96192660
126Abnormality of eosinophils (HP:0001879)1.96088669
127Atrial fibrillation (HP:0005110)1.95482991
128Lymphoma (HP:0002665)1.94960122
129Restrictive lung disease (HP:0002091)1.93224442
130Fatigue (HP:0012378)1.93054169
131Osteomyelitis (HP:0002754)1.92030668
132Weak cry (HP:0001612)1.91567142
133Urinary urgency (HP:0000012)1.90427298
134Scapular winging (HP:0003691)1.90413079
135Protruding tongue (HP:0010808)1.90231062
136Malignant hyperthermia (HP:0002047)1.89971099
137Vertebral arch anomaly (HP:0008438)1.89543884
138Gowers sign (HP:0003391)1.88448663
139Sepsis (HP:0100806)1.88041680
140Autoimmune thrombocytopenia (HP:0001973)1.85275167
141Generalized tonic-clonic seizures (HP:0002069)1.83735256
142Prolonged QT interval (HP:0001657)1.83418592
143Calcaneovalgus deformity (HP:0001848)1.83023256
144Muscular dystrophy (HP:0003560)1.82682107
145Abnormal EKG (HP:0003115)1.82493417
146Pancreatic cysts (HP:0001737)1.81728680
147Primary atrial arrhythmia (HP:0001692)1.81563064
148Spontaneous hematomas (HP:0007420)1.81276801
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80000800
150Hypoplastic ischia (HP:0003175)1.79903344
151Heart block (HP:0012722)1.78825785
152Hemiparesis (HP:0001269)1.78418092
153Chest pain (HP:0100749)1.78073540
154Granulocytopenia (HP:0001913)1.77195988
155Supranuclear gaze palsy (HP:0000605)1.76922078
156Visual hallucinations (HP:0002367)1.76792384
157Type II lissencephaly (HP:0007260)1.76474889
158Abnormality of binocular vision (HP:0011514)1.76454634
159Diplopia (HP:0000651)1.76454634
160Sparse lateral eyebrow (HP:0005338)1.75878711
161Dysmetric saccades (HP:0000641)1.75857019
162Decreased circulating renin level (HP:0003351)1.75839003
163Keratoconjunctivitis (HP:0001096)1.73847418
164Abnormality of alanine metabolism (HP:0010916)1.72993873
165Hyperalaninemia (HP:0003348)1.72993873
166Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72993873
167Mediastinal lymphadenopathy (HP:0100721)1.70526463
168Macroorchidism (HP:0000053)1.70031334
169Slender build (HP:0001533)1.70005912
170Proximal amyotrophy (HP:0007126)1.69982514
171Prolonged bleeding time (HP:0003010)1.69906652
172Hip contracture (HP:0003273)1.69636818
173Steppage gait (HP:0003376)1.69025273
174Abnormality of the renal cortex (HP:0011035)1.68953024
175Epileptic encephalopathy (HP:0200134)1.68681919
176Ureteral stenosis (HP:0000071)1.68551055
177Leukocytosis (HP:0001974)1.68402644
178Petechiae (HP:0000967)1.67546862
179Abnormality of the ischium (HP:0003174)1.67471526
180Abnormal hair whorl (HP:0010721)1.65564308
181Recurrent pneumonia (HP:0006532)1.65248502
182Hepatitis (HP:0012115)1.64990661
183Abnormality of the shoulder girdle musculature (HP:0001435)1.64738186
184Truncal ataxia (HP:0002078)1.64521268
185Recurrent abscess formation (HP:0002722)1.63959903
186Poor eye contact (HP:0000817)1.63156815
187Interstitial pulmonary disease (HP:0006530)1.62604426
188Supraventricular tachycardia (HP:0004755)1.62096835
189Seborrheic dermatitis (HP:0001051)1.61366325
190Impaired smooth pursuit (HP:0007772)1.61206881
191Volvulus (HP:0002580)1.59552534
192Retrobulbar optic neuritis (HP:0100654)1.59028986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.16426395
2MAP4K15.70148943
3EEF2K4.40658397
4PHKG23.48271555
5PHKG13.48271555
6TTN3.09581182
7TXK3.06188826
8GRK62.80766119
9PINK12.51128385
10PIK3CG2.49531014
11JAK32.49501340
12STK102.42469447
13TNK22.41272361
14MAP3K132.38279778
15MST42.11235425
16ITK2.09612196
17SYK2.05202728
18SIK21.98613003
19ADRBK21.90674908
20LRRK21.88992628
21BTK1.86435677
22ZAP701.85681743
23TYK21.84905106
24FES1.73700039
25TLK11.71496471
26CAMKK21.71150557
27MAP3K101.67100633
28MARK11.66653776
29JAK11.65077256
30PKN21.62656086
31AKT31.59004274
32MAP3K121.58687020
33BMPR1B1.52759344
34CSF1R1.52352250
35LCK1.48911995
36PRKCQ1.46212319
37FGFR31.45089702
38MAP3K71.42478297
39TESK21.37758917
40PRKCH1.34772711
41MAP3K141.33386111
42BLK1.30957152
43TRPM71.30897038
44ALK1.30237845
45MAPK131.30208469
46TAOK31.29317736
47RIPK41.27131148
48HCK1.26079479
49PIK3CA1.23091481
50MAP2K31.19239867
51PDK11.18797679
52DAPK21.17786510
53FGFR41.13928558
54CASK1.07621015
55GRK11.07424728
56SCYL21.06933964
57ACVR1B1.06149167
58ADRBK11.02051963
59IKBKE1.01672076
60TEC1.00554606
61ERN10.99613389
62MAP2K60.98705813
63MAPKAPK30.98497994
64NLK0.97256604
65MAPK70.97079029
66MAP2K40.96198184
67CLK10.93399716
68MUSK0.92910922
69SGK20.92702019
70PAK30.92056810
71MOS0.91784527
72PAK60.91476485
73PTK2B0.90484376
74JAK20.89800283
75MARK30.89481384
76NTRK30.87395545
77WNK10.87159911
78PRKD20.84121731
79CAMK10.81663602
80CAMK40.81475586
81CAMK2A0.79525159
82MAP3K90.77439716
83OXSR10.76253020
84TRIB30.76194458
85LYN0.74065994
86MAP3K20.73311205
87CSK0.72749344
88STK380.70546254
89WNK30.68958499
90KSR20.68900623
91TYRO30.68875672
92FRK0.66268355
93RET0.65906504
94MARK20.65404365
95INSRR0.64924935
96SGK30.64809994
97EPHB10.64328546
98CAMKK10.64061420
99CAMK2B0.63994725
100RPS6KB20.63909575
101FYN0.61895888
102MAP2K10.58250124
103GRK70.58116446
104CDK120.57777356
105HIPK20.56301804
106PKN10.55980339
107KIT0.55260905
108PLK20.55076152
109PRKAA10.55056548
110SGK4940.55035345
111SGK2230.55035345
112ERBB30.53578507
113STK110.53135244
114PRKAA20.53040764
115PRKCG0.50993838
116PRKCE0.49898335
117ROCK20.49595154
118CDC42BPA0.49233346
119NEK20.49016767
120CDK190.48809461
121CAMK2D0.47526442
122PRKG10.47340352
123PTK60.46621456
124GRK50.46481732
125FGFR20.44958446
126RAF10.44635645
127MINK10.44616688
128LIMK10.44487443
129TBK10.44117305
130PIM10.42530744
131TESK10.40309341
132NEK90.38606967
133SGK10.37663486
134MAPK120.37196367
135UHMK10.35461422
136MAPK110.34741814
137PDPK10.34257003
138MAP3K40.34119677
139IKBKB0.34086584
140MAP4K20.33990852
141TAOK10.33393797
142RPS6KA30.31938016
143CSNK1D0.31856941
144PDGFRB0.31818247
145SIK10.31204309
146PRKD30.30154975
147SIK30.28951992
148TGFBR20.26651781
149INSR0.26427865
150NTRK20.25849672
151CDK50.25810480
152IRAK40.24546380
153CAMK1G0.23690907
154PNCK0.22466598
155SRC0.22125173
156EGFR0.22098724
157CDK40.21402016

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.61927896
2B cell receptor signaling pathway_Homo sapiens_hsa046622.79840357
3T cell receptor signaling pathway_Homo sapiens_hsa046602.74061657
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.68796945
5Dilated cardiomyopathy_Homo sapiens_hsa054142.50092143
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.23081839
7Circadian rhythm_Homo sapiens_hsa047102.08473814
8Calcium signaling pathway_Homo sapiens_hsa040202.00894783
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.87905254
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.87376826
11Phototransduction_Homo sapiens_hsa047441.75974585
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72845578
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69276170
14Insulin secretion_Homo sapiens_hsa049111.62293802
15Antigen processing and presentation_Homo sapiens_hsa046121.61960335
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59070169
17Cardiac muscle contraction_Homo sapiens_hsa042601.58118451
18Measles_Homo sapiens_hsa051621.57860228
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.57804092
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.54870868
21GABAergic synapse_Homo sapiens_hsa047271.52488328
22Osteoclast differentiation_Homo sapiens_hsa043801.46295341
23Long-term potentiation_Homo sapiens_hsa047201.44871477
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.42842923
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41653174
26Hematopoietic cell lineage_Homo sapiens_hsa046401.39356670
27Taste transduction_Homo sapiens_hsa047421.37183436
28Nitrogen metabolism_Homo sapiens_hsa009101.36946281
29Long-term depression_Homo sapiens_hsa047301.36472080
30Non-small cell lung cancer_Homo sapiens_hsa052231.31592426
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31591080
32Chronic myeloid leukemia_Homo sapiens_hsa052201.27832359
33Chemokine signaling pathway_Homo sapiens_hsa040621.27576702
34Acute myeloid leukemia_Homo sapiens_hsa052211.26747608
35cAMP signaling pathway_Homo sapiens_hsa040241.26468781
36Pancreatic cancer_Homo sapiens_hsa052121.19921255
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.17521126
38VEGF signaling pathway_Homo sapiens_hsa043701.16583173
39Inositol phosphate metabolism_Homo sapiens_hsa005621.15917660
40Glioma_Homo sapiens_hsa052141.11279466
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.09812626
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08536402
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.08367870
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07970354
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06097511
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06054753
47Gastric acid secretion_Homo sapiens_hsa049711.05637877
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04538976
49Platelet activation_Homo sapiens_hsa046111.04362696
50Serotonergic synapse_Homo sapiens_hsa047261.02644050
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02120017
52Leishmaniasis_Homo sapiens_hsa051401.00525660
53Hepatitis B_Homo sapiens_hsa051610.99941181
54Olfactory transduction_Homo sapiens_hsa047400.99873324
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98375659
56Allograft rejection_Homo sapiens_hsa053300.98035791
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97628821
58Glucagon signaling pathway_Homo sapiens_hsa049220.97043600
59ErbB signaling pathway_Homo sapiens_hsa040120.95817610
60Toxoplasmosis_Homo sapiens_hsa051450.95621248
61Endometrial cancer_Homo sapiens_hsa052130.94929301
62Colorectal cancer_Homo sapiens_hsa052100.94787136
63Insulin resistance_Homo sapiens_hsa049310.93336906
64Regulation of autophagy_Homo sapiens_hsa041400.92823262
65Choline metabolism in cancer_Homo sapiens_hsa052310.92068431
66mTOR signaling pathway_Homo sapiens_hsa041500.91808082
67Prolactin signaling pathway_Homo sapiens_hsa049170.91767262
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91623514
69GnRH signaling pathway_Homo sapiens_hsa049120.91248573
70Salivary secretion_Homo sapiens_hsa049700.87663562
71Endocytosis_Homo sapiens_hsa041440.86641349
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.84474432
73Selenocompound metabolism_Homo sapiens_hsa004500.84326263
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83879111
75Type II diabetes mellitus_Homo sapiens_hsa049300.83112035
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81742927
77Dorso-ventral axis formation_Homo sapiens_hsa043200.81508469
78Morphine addiction_Homo sapiens_hsa050320.80986198
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79574084
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78939290
81Shigellosis_Homo sapiens_hsa051310.78818207
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78485348
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78341204
84Synaptic vesicle cycle_Homo sapiens_hsa047210.77796635
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75883406
86Oxytocin signaling pathway_Homo sapiens_hsa049210.75631816
87Amphetamine addiction_Homo sapiens_hsa050310.75619151
88MAPK signaling pathway_Homo sapiens_hsa040100.75610368
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75300791
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74835427
91Glutamatergic synapse_Homo sapiens_hsa047240.74439084
92Autoimmune thyroid disease_Homo sapiens_hsa053200.73950984
93Herpes simplex infection_Homo sapiens_hsa051680.73715467
94Dopaminergic synapse_Homo sapiens_hsa047280.73595290
95Estrogen signaling pathway_Homo sapiens_hsa049150.71522222
96Influenza A_Homo sapiens_hsa051640.70977405
97Renin secretion_Homo sapiens_hsa049240.70823938
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69050416
99Hepatitis C_Homo sapiens_hsa051600.68764563
100Cholinergic synapse_Homo sapiens_hsa047250.68760146
101Viral myocarditis_Homo sapiens_hsa054160.68013508
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67861710
103Non-homologous end-joining_Homo sapiens_hsa034500.67101071
104HTLV-I infection_Homo sapiens_hsa051660.67071899
105Circadian entrainment_Homo sapiens_hsa047130.66469304
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66205083
107ABC transporters_Homo sapiens_hsa020100.65373808
108Prostate cancer_Homo sapiens_hsa052150.64583750
109Butanoate metabolism_Homo sapiens_hsa006500.64415799
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.64185446
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64121700
112Insulin signaling pathway_Homo sapiens_hsa049100.63887497
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63488985
114Ras signaling pathway_Homo sapiens_hsa040140.63099453
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61032000
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60880839
117Tuberculosis_Homo sapiens_hsa051520.59854539
118Linoleic acid metabolism_Homo sapiens_hsa005910.58391398
119FoxO signaling pathway_Homo sapiens_hsa040680.58388224
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57956621
121Asthma_Homo sapiens_hsa053100.57034546
122Ether lipid metabolism_Homo sapiens_hsa005650.56369530
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56206704
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56171455
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55939742
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55891726
127Graft-versus-host disease_Homo sapiens_hsa053320.55424262
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55074451
129Rap1 signaling pathway_Homo sapiens_hsa040150.54998939
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54964736
131AMPK signaling pathway_Homo sapiens_hsa041520.54651536
132Renal cell carcinoma_Homo sapiens_hsa052110.54415692
133Pancreatic secretion_Homo sapiens_hsa049720.54311916
134Nicotine addiction_Homo sapiens_hsa050330.54113848
135Apoptosis_Homo sapiens_hsa042100.53914428
136Ovarian steroidogenesis_Homo sapiens_hsa049130.53906969
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53695972
138Viral carcinogenesis_Homo sapiens_hsa052030.53389765
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52923579
140Cocaine addiction_Homo sapiens_hsa050300.51265776
141Melanoma_Homo sapiens_hsa052180.48603873
142Tryptophan metabolism_Homo sapiens_hsa003800.41879316
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40717204
144African trypanosomiasis_Homo sapiens_hsa051430.39378260
145Focal adhesion_Homo sapiens_hsa045100.37981173

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