NXPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.97570822
2vocalization behavior (GO:0071625)5.81275781
3DNA integration (GO:0015074)5.72663257
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.62603936
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37142946
6regulation of glutamate receptor signaling pathway (GO:1900449)5.32469798
7retinal cone cell development (GO:0046549)5.28485017
8synaptic vesicle exocytosis (GO:0016079)5.24157146
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11496094
10glycosphingolipid biosynthetic process (GO:0006688)5.11132128
11gamma-aminobutyric acid transport (GO:0015812)4.94939747
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.89688279
13substrate-independent telencephalic tangential migration (GO:0021826)4.89115887
14substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.89115887
15locomotory exploration behavior (GO:0035641)4.88480939
16protein localization to synapse (GO:0035418)4.70293768
17regulation of synaptic vesicle exocytosis (GO:2000300)4.69551123
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.68093487
19establishment of mitochondrion localization (GO:0051654)4.65784446
20glutamate secretion (GO:0014047)4.62687850
21neurotransmitter secretion (GO:0007269)4.62286496
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60608522
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.57323036
24presynaptic membrane assembly (GO:0097105)4.52214652
25postsynaptic membrane organization (GO:0001941)4.47244992
26protein-cofactor linkage (GO:0018065)4.46423202
27synaptic vesicle maturation (GO:0016188)4.38126611
28neurotransmitter-gated ion channel clustering (GO:0072578)4.34929608
29exploration behavior (GO:0035640)4.26929959
30positive regulation of synaptic transmission, GABAergic (GO:0032230)4.26680499
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.25906660
32cAMP catabolic process (GO:0006198)4.24988029
33synaptic transmission, glutamatergic (GO:0035249)4.23940525
34presynaptic membrane organization (GO:0097090)4.22355642
35neuronal action potential propagation (GO:0019227)4.22325923
36limb bud formation (GO:0060174)4.15644704
37negative regulation of oligodendrocyte differentiation (GO:0048715)4.13584701
38pyrimidine nucleobase catabolic process (GO:0006208)4.10074861
39neuron-neuron synaptic transmission (GO:0007270)4.08961142
40regulation of synaptic vesicle transport (GO:1902803)4.08800483
41neuron recognition (GO:0008038)4.08515098
42positive regulation of mitochondrial fission (GO:0090141)4.07734302
43glial cell proliferation (GO:0014009)4.06123982
44nonmotile primary cilium assembly (GO:0035058)4.05331548
45layer formation in cerebral cortex (GO:0021819)4.05160131
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.02472969
47glutamate receptor signaling pathway (GO:0007215)4.02458325
48regulation of synapse structural plasticity (GO:0051823)4.00566654
49protein insertion into membrane (GO:0051205)3.93787708
50proline transport (GO:0015824)3.92702159
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92092803
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.90378870
53succinate metabolic process (GO:0006105)3.88456796
54cyclic nucleotide catabolic process (GO:0009214)3.87440681
55pyrimidine dimer repair (GO:0006290)3.86166204
56C4-dicarboxylate transport (GO:0015740)3.85371071
57regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.84559894
58synaptic vesicle docking involved in exocytosis (GO:0016081)3.81784368
59startle response (GO:0001964)3.80474139
60lipopolysaccharide biosynthetic process (GO:0009103)3.71864900
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.68669027
62neurotransmitter transport (GO:0006836)3.67721557
63regulation of neuronal synaptic plasticity (GO:0048168)3.64575857
64positive regulation of vesicle fusion (GO:0031340)3.64077129
65positive regulation of synapse assembly (GO:0051965)3.62419165
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62403376
67cardiac ventricle formation (GO:0003211)3.60552786
68hippocampus development (GO:0021766)3.60281399
69positive regulation of membrane potential (GO:0045838)3.55981737
70regulation of synapse maturation (GO:0090128)3.53916003
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.52839487
72regulation of synaptic transmission, GABAergic (GO:0032228)3.50256000
73dendritic spine morphogenesis (GO:0060997)3.47073199
74DNA double-strand break processing (GO:0000729)3.45866415
75sequestering of actin monomers (GO:0042989)3.45055400
76neural tube formation (GO:0001841)3.42137641
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41618534
78neurotransmitter biosynthetic process (GO:0042136)3.40788016
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40601150
80regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39598426
81sialylation (GO:0097503)3.39219410
82nucleobase catabolic process (GO:0046113)3.38590484
83cell migration in hindbrain (GO:0021535)3.38520600
84long-term memory (GO:0007616)3.35711546
85transmission of nerve impulse (GO:0019226)3.35660834
86regulation of neurotransmitter levels (GO:0001505)3.35362318
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34903773
88dendrite morphogenesis (GO:0048813)3.32787790
89long-term synaptic potentiation (GO:0060291)3.32527833
90amino acid import (GO:0043090)3.32442444
91calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.30921779
92positive regulation of CREB transcription factor activity (GO:0032793)3.29637814
93axonal fasciculation (GO:0007413)3.29286039
94synapse assembly (GO:0007416)3.29239658
95mechanosensory behavior (GO:0007638)3.29231099
96cardiac chamber formation (GO:0003207)3.28943105
97regulation of development, heterochronic (GO:0040034)3.25750688
98glycine transport (GO:0015816)3.25338312
99lipopolysaccharide metabolic process (GO:0008653)3.25275832
100membrane hyperpolarization (GO:0060081)3.24746726
101regulation of postsynaptic membrane potential (GO:0060078)3.23224512
102ganglioside metabolic process (GO:0001573)3.22504537
103L-serine transport (GO:0015825)3.21513422
104regulation of respiratory system process (GO:0044065)3.20415574
105positive regulation of amino acid transport (GO:0051957)3.18036313
106apical protein localization (GO:0045176)3.17853650
107dicarboxylic acid catabolic process (GO:0043649)3.17101389
108positive regulation of synapse maturation (GO:0090129)3.16700030
109response to auditory stimulus (GO:0010996)3.12381389
110regulation of protein kinase A signaling (GO:0010738)3.10299875
111neuromuscular process controlling posture (GO:0050884)3.09380242
112ATP hydrolysis coupled proton transport (GO:0015991)3.07916603
113energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.07916603
114activation of protein kinase A activity (GO:0034199)3.07026374
115learning (GO:0007612)3.04662872
116regulation of neurotransmitter secretion (GO:0046928)3.03995611
117positive regulation of synaptic transmission (GO:0050806)3.02480784
118regulation of dendritic spine morphogenesis (GO:0061001)3.01035316
119regulation of synaptic plasticity (GO:0048167)3.00500201
120sympathetic nervous system development (GO:0048485)3.00423621
121synaptic transmission (GO:0007268)2.99314658
122cerebellar Purkinje cell differentiation (GO:0021702)2.99184630
123response to pheromone (GO:0019236)2.98645061
124RNA localization (GO:0006403)2.98449832
125somite development (GO:0061053)2.97876320
126cullin deneddylation (GO:0010388)2.97536258
127innervation (GO:0060384)2.97168356
128endoplasmic reticulum organization (GO:0007029)2.96817329
129regulation of synapse assembly (GO:0051963)2.96755238
130synapse organization (GO:0050808)2.95363086
131protein polyglutamylation (GO:0018095)2.95341969
132righting reflex (GO:0060013)2.95265918
133auditory behavior (GO:0031223)2.94258206
134social behavior (GO:0035176)2.93957332
135intraspecies interaction between organisms (GO:0051703)2.93957332
136positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.92810445
137cerebral cortex radially oriented cell migration (GO:0021799)2.92629552
138transferrin transport (GO:0033572)2.92324572
139cornea development in camera-type eye (GO:0061303)2.92143574
140regulation of neurotransmitter transport (GO:0051588)2.91682135
141regulation of feeding behavior (GO:0060259)2.91355190
142regulation of cAMP-dependent protein kinase activity (GO:2000479)2.90735707
143membrane depolarization (GO:0051899)2.89408406
144neurofilament cytoskeleton organization (GO:0060052)2.89188878
145detection of calcium ion (GO:0005513)2.88764531
146mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.88588783
147regulation of synaptic transmission, dopaminergic (GO:0032225)2.87840862
148muscle organ morphogenesis (GO:0048644)2.87601837
149regulation of cofactor metabolic process (GO:0051193)2.87421351
150regulation of coenzyme metabolic process (GO:0051196)2.87421351
151protein localization to cilium (GO:0061512)2.86351739
152regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86303573
153response to dietary excess (GO:0002021)2.85572726
154regulation of vesicle fusion (GO:0031338)2.85436831
155response to histamine (GO:0034776)2.85077069
156cGMP metabolic process (GO:0046068)2.84605302
157negative regulation of microtubule polymerization (GO:0031115)2.84311749
158establishment of melanosome localization (GO:0032401)2.84298726
159cerebellar granule cell differentiation (GO:0021707)2.82243386
160regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81640437
161regulation of mitochondrial fission (GO:0090140)2.81091787
162L-fucose catabolic process (GO:0042355)2.78169205
163L-fucose metabolic process (GO:0042354)2.78169205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83018181
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.36547879
3* GBX2_23144817_ChIP-Seq_PC3_Human4.20572250
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17426874
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97774042
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96996969
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69121305
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.68986817
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.65906816
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.65356466
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62741689
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57052513
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55678433
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54765645
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54765645
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52425243
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50274664
18TAF15_26573619_Chip-Seq_HEK293_Human2.49675649
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.37586130
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34786251
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34100118
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32229657
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27648068
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23895693
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19312352
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18779264
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18540057
28AR_21572438_ChIP-Seq_LNCaP_Human2.16043649
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12999399
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.09602943
31DROSHA_22980978_ChIP-Seq_HELA_Human1.96481695
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95823234
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94432438
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.91629705
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.86940230
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79822984
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.73608429
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72979864
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72316840
40P300_19829295_ChIP-Seq_ESCs_Human1.70588058
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.67768298
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63808898
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62141283
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59375398
45ZNF274_21170338_ChIP-Seq_K562_Hela1.56179718
46* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55992407
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54962235
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54884783
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53925231
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53300282
51IGF1R_20145208_ChIP-Seq_DFB_Human1.50202922
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.50197130
53RNF2_27304074_Chip-Seq_NSC_Mouse1.49023610
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47301652
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45643461
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44505308
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43823145
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43182815
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.42002526
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40878387
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.39734262
62AR_25329375_ChIP-Seq_VCAP_Human1.37915408
63* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37676126
64EWS_26573619_Chip-Seq_HEK293_Human1.37546761
65CBP_20019798_ChIP-Seq_JUKART_Human1.37389593
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37389593
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37280051
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36543270
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36092627
70FUS_26573619_Chip-Seq_HEK293_Human1.35035342
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32331460
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.30877678
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29916516
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.27964866
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27802741
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25439570
77* STAT3_23295773_ChIP-Seq_U87_Human1.24932018
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23326026
79ER_23166858_ChIP-Seq_MCF-7_Human1.19894752
80GATA1_22025678_ChIP-Seq_K562_Human1.19215936
81* ERG_21242973_ChIP-ChIP_JURKAT_Human1.19006677
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18721015
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16929001
84* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14682392
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14383268
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13330320
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12759004
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12521280
89VDR_23849224_ChIP-Seq_CD4+_Human1.12231258
90RUNX2_22187159_ChIP-Seq_PCA_Human1.10732855
91* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10480793
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09238825
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08336057
94TCF4_23295773_ChIP-Seq_U87_Human1.08167985
95TP53_22573176_ChIP-Seq_HFKS_Human1.07929769
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06986430
97* AR_19668381_ChIP-Seq_PC3_Human1.06967688
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06418318
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.05743864
100IRF1_19129219_ChIP-ChIP_H3396_Human1.05554384
101SOX2_16153702_ChIP-ChIP_HESCs_Human1.02999305
102* JUN_21703547_ChIP-Seq_K562_Human1.02066747
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01135890
104AHR_22903824_ChIP-Seq_MCF-7_Human1.00185427
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99479662
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.99309355
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98590796
108ELK1_19687146_ChIP-ChIP_HELA_Human0.98551783
109* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98375701
110VDR_22108803_ChIP-Seq_LS180_Human0.98158233
111SMAD_19615063_ChIP-ChIP_OVARY_Human0.97861193
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.97838775
113* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97749884
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97342813
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96709629
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96661465
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.96575782
118GABP_19822575_ChIP-Seq_HepG2_Human0.96407249
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.96184400
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.95694558
121* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92135670
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91596675
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90632997
124* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90614425
125MYC_18940864_ChIP-ChIP_HL60_Human0.90361698
126BCAT_22108803_ChIP-Seq_LS180_Human0.90302320
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.89648605
128* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88953446
129* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88726715
130* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88726715
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87980351
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87767431
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87669161
134TP53_18474530_ChIP-ChIP_U2OS_Human0.87306761
135KDM2B_26808549_Chip-Seq_REH_Human0.86577020
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85792153
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84947244
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84612568
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83769988
140CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83397830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09002608
2MP0003880_abnormal_central_pattern4.62155031
3MP0003635_abnormal_synaptic_transmissio3.95271127
4MP0002102_abnormal_ear_morphology3.60933957
5MP0009046_muscle_twitch3.39082127
6MP0009745_abnormal_behavioral_response3.34622214
7MP0002064_seizures3.23473419
8MP0005423_abnormal_somatic_nervous3.21779140
9MP0002063_abnormal_learning/memory/cond3.17942800
10MP0004270_analgesia3.11613841
11MP0001968_abnormal_touch/_nociception2.95401043
12MP0002572_abnormal_emotion/affect_behav2.89722063
13MP0001486_abnormal_startle_reflex2.76509092
14MP0002272_abnormal_nervous_system2.68422283
15MP0002734_abnormal_mechanical_nocicepti2.56096849
16MP0002736_abnormal_nociception_after2.50349024
17MP0005645_abnormal_hypothalamus_physiol2.40120807
18MP0008789_abnormal_olfactory_epithelium2.32739968
19MP0006276_abnormal_autonomic_nervous2.21074230
20MP0003122_maternal_imprinting2.20920265
21MP0001501_abnormal_sleep_pattern2.18910804
22MP0001529_abnormal_vocalization2.18883814
23MP0002184_abnormal_innervation2.11159499
24MP0002067_abnormal_sensory_capabilities2.10327587
25MP0002733_abnormal_thermal_nociception2.08704915
26MP0000778_abnormal_nervous_system2.03575346
27MP0002735_abnormal_chemical_nociception2.03510274
28MP0002557_abnormal_social/conspecific_i1.99198456
29MP0001970_abnormal_pain_threshold1.98669791
30MP0001440_abnormal_grooming_behavior1.95197332
31MP0003787_abnormal_imprinting1.87262409
32MP0000049_abnormal_middle_ear1.83267268
33MP0001270_distended_abdomen1.78657218
34MP0005646_abnormal_pituitary_gland1.78102574
35MP0002277_abnormal_respiratory_mucosa1.77346339
36MP0004142_abnormal_muscle_tone1.75588556
37MP0001984_abnormal_olfaction1.75107940
38MP0004924_abnormal_behavior1.73202263
39MP0005386_behavior/neurological_phenoty1.73202263
40MP0008569_lethality_at_weaning1.65008053
41MP0004811_abnormal_neuron_physiology1.64466436
42MP0008995_early_reproductive_senescence1.61273143
43MP0004858_abnormal_nervous_system1.60238449
44MP0009780_abnormal_chondrocyte_physiolo1.58107259
45MP0000955_abnormal_spinal_cord1.55999120
46MP0002909_abnormal_adrenal_gland1.50836782
47MP0003938_abnormal_ear_development1.44569543
48MP0002066_abnormal_motor_capabilities/c1.44171679
49MP0002882_abnormal_neuron_morphology1.42007961
50MP0003879_abnormal_hair_cell1.41960423
51MP0000569_abnormal_digit_pigmentation1.37404584
52MP0001188_hyperpigmentation1.37282672
53MP0003221_abnormal_cardiomyocyte_apopto1.36451225
54MP0000013_abnormal_adipose_tissue1.35292250
55MP0010386_abnormal_urinary_bladder1.35071365
56MP0003329_amyloid_beta_deposits1.33360317
57MP0002837_dystrophic_cardiac_calcinosis1.32817892
58MP0005367_renal/urinary_system_phenotyp1.28014939
59MP0000516_abnormal_urinary_system1.28014939
60MP0002249_abnormal_larynx_morphology1.25515721
61MP0001502_abnormal_circadian_rhythm1.22353430
62MP0004885_abnormal_endolymph1.21700251
63MP0002638_abnormal_pupillary_reflex1.20109745
64MP0002332_abnormal_exercise_endurance1.18869559
65MP0004742_abnormal_vestibular_system1.18715819
66MP0000631_abnormal_neuroendocrine_gland1.17650418
67MP0002152_abnormal_brain_morphology1.17308248
68MP0001905_abnormal_dopamine_level1.15664799
69MP0001986_abnormal_taste_sensitivity1.13112823
70MP0002653_abnormal_ependyma_morphology1.11393139
71MP0005187_abnormal_penis_morphology1.06569380
72MP0003183_abnormal_peptide_metabolism1.05124600
73MP0002822_catalepsy1.04984300
74MP0005670_abnormal_white_adipose0.99081605
75MP0003119_abnormal_digestive_system0.99006155
76MP0000751_myopathy0.98865277
77MP0005253_abnormal_eye_physiology0.98354795
78MP0002069_abnormal_eating/drinking_beha0.95836582
79MP0001963_abnormal_hearing_physiology0.95721381
80MP0005084_abnormal_gallbladder_morpholo0.95337453
81MP0000750_abnormal_muscle_regeneration0.94348076
82MP0003121_genomic_imprinting0.93221010
83MP0003634_abnormal_glial_cell0.93123074
84MP0003633_abnormal_nervous_system0.92814785
85MP0001764_abnormal_homeostasis0.92034036
86MP0002876_abnormal_thyroid_physiology0.91439358
87MP0002229_neurodegeneration0.90982945
88MP0000647_abnormal_sebaceous_gland0.87381918
89MP0003631_nervous_system_phenotype0.84534551
90MP0003646_muscle_fatigue0.84284501
91MP0004134_abnormal_chest_morphology0.83617257
92MP0001177_atelectasis0.83108141
93MP0008877_abnormal_DNA_methylation0.82941616
94MP0002752_abnormal_somatic_nervous0.81456464
95MP0005551_abnormal_eye_electrophysiolog0.79996221
96MP0002177_abnormal_outer_ear0.78703591
97MP0006292_abnormal_olfactory_placode0.78564548
98MP0004085_abnormal_heartbeat0.77330454
99MP0009384_cardiac_valve_regurgitation0.76521163
100MP0004215_abnormal_myocardial_fiber0.74110576
101MP0005499_abnormal_olfactory_system0.74068506
102MP0005394_taste/olfaction_phenotype0.74068506
103MP0001664_abnormal_digestion0.73339069
104MP0000639_abnormal_adrenal_gland0.70892221
105MP0004484_altered_response_of0.70374997
106MP0003755_abnormal_palate_morphology0.70001040
107MP0003137_abnormal_impulse_conducting0.69075964
108MP0000015_abnormal_ear_pigmentation0.68550060
109MP0002234_abnormal_pharynx_morphology0.68126629
110MP0001943_abnormal_respiration0.68018624
111MP0008872_abnormal_physiological_respon0.67822664
112MP0000026_abnormal_inner_ear0.67543018
113MP0003385_abnormal_body_wall0.67222560
114MP0005171_absent_coat_pigmentation0.66353714
115MP0005535_abnormal_body_temperature0.66275014
116MP0004145_abnormal_muscle_electrophysio0.66131921
117MP0003632_abnormal_nervous_system0.65324322
118MP0003861_abnormal_nervous_system0.65005514
119MP0002751_abnormal_autonomic_nervous0.64336040
120MP0001299_abnormal_eye_distance/0.62396559
121MP0000920_abnormal_myelination0.59745976
122MP0004233_abnormal_muscle_weight0.59685826
123MP0010770_preweaning_lethality0.58635622
124MP0002082_postnatal_lethality0.58635622
125MP0008961_abnormal_basal_metabolism0.56773274
126MP0008874_decreased_physiological_sensi0.56224447
127MP0010769_abnormal_survival0.55800827
128MP0004043_abnormal_pH_regulation0.55271092
129MP0001485_abnormal_pinna_reflex0.54874475
130MP0005379_endocrine/exocrine_gland_phen0.52243207

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.34422714
2Myokymia (HP:0002411)5.04199559
3Split foot (HP:0001839)4.95204749
4Focal seizures (HP:0007359)4.94056920
5Atonic seizures (HP:0010819)4.93821178
6Febrile seizures (HP:0002373)4.54880158
7Epileptic encephalopathy (HP:0200134)4.54356148
8Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.53551680
9Visual hallucinations (HP:0002367)4.15972985
10Progressive cerebellar ataxia (HP:0002073)4.04083009
11Absence seizures (HP:0002121)4.02085199
12Peripheral hypomyelination (HP:0007182)3.88963498
13Polyphagia (HP:0002591)3.84108528
14Cortical dysplasia (HP:0002539)3.80712485
15Tubulointerstitial nephritis (HP:0001970)3.66728241
16Hyperventilation (HP:0002883)3.65625723
17Dialeptic seizures (HP:0011146)3.55646213
18Limb dystonia (HP:0002451)3.51532598
19Generalized tonic-clonic seizures (HP:0002069)3.46997000
20Progressive inability to walk (HP:0002505)3.46549356
21Hepatoblastoma (HP:0002884)3.42754226
22Abnormal eating behavior (HP:0100738)3.41695269
23Delayed CNS myelination (HP:0002188)3.29863188
24Type II lissencephaly (HP:0007260)3.21804039
25Broad-based gait (HP:0002136)3.13989381
26Ulnar claw (HP:0001178)3.12510111
27Methylmalonic acidemia (HP:0002912)3.09979996
28Pheochromocytoma (HP:0002666)3.08971269
29Pachygyria (HP:0001302)3.06896478
30Abnormal hair whorl (HP:0010721)3.04428610
31Abnormality of binocular vision (HP:0011514)3.03704953
32Diplopia (HP:0000651)3.03704953
33Ankle clonus (HP:0011448)3.02770889
34Mutism (HP:0002300)2.96130248
35Impaired vibration sensation in the lower limbs (HP:0002166)2.96039515
36Neuroendocrine neoplasm (HP:0100634)2.92757652
37Epileptiform EEG discharges (HP:0011182)2.90352306
38Excessive salivation (HP:0003781)2.88971437
39Drooling (HP:0002307)2.88971437
40EEG with generalized epileptiform discharges (HP:0011198)2.84819670
41Abnormality of the vitamin B12 metabolism (HP:0004341)2.83389793
42Abnormality of the musculature of the pelvis (HP:0001469)2.80141688
43Abnormality of the hip-girdle musculature (HP:0001445)2.80141688
44Shoulder girdle muscle weakness (HP:0003547)2.79405477
45Failure to thrive in infancy (HP:0001531)2.76746298
46Hypsarrhythmia (HP:0002521)2.74751052
47Gait imbalance (HP:0002141)2.70434425
48Dysdiadochokinesis (HP:0002075)2.70375363
49Poor eye contact (HP:0000817)2.70244982
50Absent speech (HP:0001344)2.69581468
51Truncal ataxia (HP:0002078)2.68329923
52Supranuclear gaze palsy (HP:0000605)2.66606235
53Anxiety (HP:0000739)2.65427964
54Impaired social interactions (HP:0000735)2.64694609
55Abnormal social behavior (HP:0012433)2.64694609
56Inability to walk (HP:0002540)2.63227564
57Depression (HP:0000716)2.62970224
58Abnormality of vitamin B metabolism (HP:0004340)2.61125081
59Gaze-evoked nystagmus (HP:0000640)2.54378022
60Hemiparesis (HP:0001269)2.53062056
61Specific learning disability (HP:0001328)2.44914286
62Urinary urgency (HP:0000012)2.42799642
63Urinary bladder sphincter dysfunction (HP:0002839)2.42107351
64Fetal akinesia sequence (HP:0001989)2.41162321
65Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.40654552
66Agitation (HP:0000713)2.39242838
67Unilateral renal agenesis (HP:0000122)2.38989265
68Abnormality of the corticospinal tract (HP:0002492)2.37554658
69Neoplasm of the peripheral nervous system (HP:0100007)2.36815945
70Poor suck (HP:0002033)2.36729478
71Blue irides (HP:0000635)2.33070141
72Abnormality of the labia minora (HP:0012880)2.32401064
73Action tremor (HP:0002345)2.31654054
74Genetic anticipation (HP:0003743)2.31301679
75Pelvic girdle muscle weakness (HP:0003749)2.30169486
76Hypoplasia of the corpus callosum (HP:0002079)2.30020382
77Lissencephaly (HP:0001339)2.29799658
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29372225
79Absent hand (HP:0004050)2.28272540
80Spastic diplegia (HP:0001264)2.27430483
81Hyperglycinemia (HP:0002154)2.26973674
82Dysmetria (HP:0001310)2.25872556
83Protruding tongue (HP:0010808)2.25086093
84Open mouth (HP:0000194)2.24222297
85Amyotrophic lateral sclerosis (HP:0007354)2.23649351
86Sleep apnea (HP:0010535)2.23632760
87Focal dystonia (HP:0004373)2.22555539
88Vaginal atresia (HP:0000148)2.22326108
89Delayed gross motor development (HP:0002194)2.22266480
90Spastic tetraplegia (HP:0002510)2.21715668
91Scanning speech (HP:0002168)2.21658206
92Generalized myoclonic seizures (HP:0002123)2.21124576
93Esotropia (HP:0000565)2.20788364
94Amblyopia (HP:0000646)2.20292310
95Genital tract atresia (HP:0001827)2.20231793
96Intellectual disability, progressive (HP:0006887)2.19614737
97Abolished electroretinogram (ERG) (HP:0000550)2.17441263
98Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17044321
99Hypoplasia of the brainstem (HP:0002365)2.17044321
100Torticollis (HP:0000473)2.16984460
101Spastic gait (HP:0002064)2.16809359
102Acute necrotizing encephalopathy (HP:0006965)2.15491705
103Neuronal loss in central nervous system (HP:0002529)2.14874311
104Medial flaring of the eyebrow (HP:0010747)2.13929825
105Intellectual disability, severe (HP:0010864)2.13421013
106Medulloblastoma (HP:0002885)2.11878368
107Congenital primary aphakia (HP:0007707)2.11872815
108Akinesia (HP:0002304)2.10990159
109Stereotypic behavior (HP:0000733)2.10704547
110Thyroid-stimulating hormone excess (HP:0002925)2.10464852
111Nephrogenic diabetes insipidus (HP:0009806)2.10391566
112Neoplasm of the oral cavity (HP:0100649)2.09498272
113Methylmalonic aciduria (HP:0012120)2.07751610
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.07597073
115Abnormal mitochondria in muscle tissue (HP:0008316)2.04449452
116Polymicrogyria (HP:0002126)2.03826457
117Papilledema (HP:0001085)2.03410613
118Hyperthyroidism (HP:0000836)2.02111343
119Bradykinesia (HP:0002067)2.01115506
120Hypoventilation (HP:0002791)2.01017706
121Progressive macrocephaly (HP:0004481)2.00961659
122Poor coordination (HP:0002370)1.99980596
123Neurofibrillary tangles (HP:0002185)1.99529970
124Retinal dysplasia (HP:0007973)1.99507706
125Narrow nasal bridge (HP:0000446)1.97703977
126Optic nerve hypoplasia (HP:0000609)1.90946803
127Lower limb muscle weakness (HP:0007340)1.90361720
128Oligomenorrhea (HP:0000876)1.90031973
129Generalized hypotonia (HP:0001290)1.88286764
130Abnormality of salivation (HP:0100755)1.88102574
131Abnormality of the pubic bones (HP:0003172)1.87462580
132Clonus (HP:0002169)1.87231049
133Postural instability (HP:0002172)1.87147335
134Craniofacial dystonia (HP:0012179)1.85972539
135Cupped ear (HP:0000378)1.85935259
136Pendular nystagmus (HP:0012043)1.85348675
137Delayed myelination (HP:0012448)1.84444511
138Decreased testicular size (HP:0008734)1.83840406
139Abnormality of the metopic suture (HP:0005556)1.83825512
140Hemiplegia (HP:0002301)1.83792878
141Hip dysplasia (HP:0001385)1.83714804
142Upper limb muscle weakness (HP:0003484)1.82203473
143Steppage gait (HP:0003376)1.80084596
144Sporadic (HP:0003745)1.79982287
145Status epilepticus (HP:0002133)1.78072234
146Psychosis (HP:0000709)1.77659395
147Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77615105
148Termporal pattern (HP:0011008)1.76145325
149Hypoplastic nipples (HP:0002557)1.74587774
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74095327
151Widely spaced teeth (HP:0000687)1.72709110
152Abnormality of vitamin metabolism (HP:0100508)1.71127402
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.70416080
154Rimmed vacuoles (HP:0003805)1.70237695
155Spastic tetraparesis (HP:0001285)1.69789495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.58693257
2MARK14.49453067
3MAP3K43.61435544
4MAP2K73.40352682
5MAP3K123.23425797
6NTRK33.21606552
7EPHA33.19937309
8NTRK23.02179597
9TRIM282.83164422
10MAP3K92.61464159
11MAP4K22.41137137
12MINK12.35133862
13EPHA42.10732328
14RPS6KA42.09271339
15MAP2K42.08137102
16SRPK11.95821543
17MAPK131.92934436
18STK38L1.91444616
19WNK31.68318944
20UHMK11.67531107
21PAK61.64183364
22PNCK1.61775311
23CSNK1G11.50696167
24TNIK1.47188140
25KSR11.46476133
26BCKDK1.44905206
27DAPK21.43339402
28CDK51.41966740
29PHKG21.35547146
30PHKG11.35547146
31DAPK11.34182157
32DYRK21.32921184
33CDK191.29936999
34PLK21.24619785
35SIK21.24237864
36PRKCG1.23971749
37TESK21.23675596
38NTRK11.22715534
39PINK11.19916678
40GRK11.17183735
41ERBB31.17047977
42BMPR1B1.16701606
43FES1.16484227
44GRK71.15517749
45SIK31.08128536
46GRK51.06884523
47ERBB41.02546764
48KSR20.98318306
49AKT30.97512619
50CSNK1G20.96336854
51PAK30.96076285
52CAMK2A0.94663379
53SGK2230.92096268
54SGK4940.92096268
55PRKD30.91754821
56PRKD20.90622967
57PDK30.90000551
58PDK40.90000551
59TYRO30.88671718
60PRPF4B0.88291923
61ARAF0.86652532
62DYRK1A0.85333472
63PRKCE0.84588227
64SGK20.84344649
65TESK10.80131693
66TAOK10.79954846
67CAMK2B0.79439432
68TSSK60.78218813
69BCR0.77513294
70CAMKK10.76894661
71OXSR10.76541573
72CDK180.76042654
73NME10.75718960
74LIMK10.75707350
75CDK140.72772050
76TAOK30.71895004
77CDK150.69022171
78RPS6KA50.67352075
79CAMK40.65353944
80FRK0.64281148
81CSNK1G30.62917267
82MAP3K50.62236223
83PRKCH0.61511621
84LATS20.61421045
85ADRBK20.60814741
86CDK11A0.60372915
87STK380.58386601
88SGK10.57049842
89CSNK1A1L0.55567827
90NEK10.55416189
91DYRK1B0.55102853
92PRKCZ0.54851876
93PKN10.54326410
94FER0.52824866
95FGFR20.52648969
96CAMK10.52381564
97MARK20.51255131
98RPS6KA20.50734378
99RET0.50265298
100PDGFRA0.49640602
101PDK20.48188890
102STK110.48105248
103MAP3K60.47754512
104CSNK1D0.47498917
105MAP3K20.46385226
106SGK30.46233685
107EIF2AK10.44815927
108ADRBK10.44801513
109RPS6KB10.44202435
110CCNB10.43977139
111ROCK10.43965275
112PRKD10.43304805
113CAMK2G0.43100362
114BRAF0.43093779
115CAMK2D0.42374358
116INSRR0.42240055
117YES10.41594717
118RPS6KA30.40331250
119RIPK40.40076885
120ALK0.38112096
121ROCK20.37532813
122CSNK1A10.37422810
123CAMKK20.37330969
124TNK20.37259989
125PRKAA10.36401050
126MAPK100.35674996
127RPS6KA10.34381276
128PRKACB0.34366661
129FYN0.33686894
130PRKACA0.33178201
131PRKACG0.30073790
132DYRK30.28655205
133ABL10.27553129
134PRKCA0.25691871
135FLT30.24856590
136MAPK90.24403608
137VRK10.23780513
138KDR0.22777743
139PRKG10.22559569
140PKN20.22294414

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.35154927
2Synaptic vesicle cycle_Homo sapiens_hsa047213.70331352
3GABAergic synapse_Homo sapiens_hsa047273.15542088
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87169962
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66162215
6Collecting duct acid secretion_Homo sapiens_hsa049662.60685232
7Morphine addiction_Homo sapiens_hsa050322.52417933
8Circadian entrainment_Homo sapiens_hsa047132.38538330
9Glutamatergic synapse_Homo sapiens_hsa047242.32530688
10Olfactory transduction_Homo sapiens_hsa047402.28294197
11Long-term potentiation_Homo sapiens_hsa047202.10911720
12Dopaminergic synapse_Homo sapiens_hsa047282.08635222
13Amphetamine addiction_Homo sapiens_hsa050312.04881284
14Taste transduction_Homo sapiens_hsa047421.93148340
15Insulin secretion_Homo sapiens_hsa049111.86787206
16Protein export_Homo sapiens_hsa030601.86267994
17Vibrio cholerae infection_Homo sapiens_hsa051101.81904373
18Serotonergic synapse_Homo sapiens_hsa047261.76173082
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74202091
20Oxidative phosphorylation_Homo sapiens_hsa001901.73488375
21Salivary secretion_Homo sapiens_hsa049701.71967080
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63978120
23Cholinergic synapse_Homo sapiens_hsa047251.60784643
24Long-term depression_Homo sapiens_hsa047301.60781881
25Cocaine addiction_Homo sapiens_hsa050301.60273780
26Renin secretion_Homo sapiens_hsa049241.43836594
27Type I diabetes mellitus_Homo sapiens_hsa049401.42216385
28Gastric acid secretion_Homo sapiens_hsa049711.42051344
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41689793
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39744797
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37057450
32Axon guidance_Homo sapiens_hsa043601.35898545
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35460584
34Gap junction_Homo sapiens_hsa045401.33311898
35Calcium signaling pathway_Homo sapiens_hsa040201.32614362
36Oxytocin signaling pathway_Homo sapiens_hsa049211.31828551
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27711602
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24278300
39Cardiac muscle contraction_Homo sapiens_hsa042601.23151247
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22645019
41Parkinsons disease_Homo sapiens_hsa050121.18544504
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18307813
43Circadian rhythm_Homo sapiens_hsa047101.17882022
44Alzheimers disease_Homo sapiens_hsa050101.16719970
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13949003
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.12383775
47beta-Alanine metabolism_Homo sapiens_hsa004101.12205239
48Butanoate metabolism_Homo sapiens_hsa006501.11680444
49GnRH signaling pathway_Homo sapiens_hsa049121.09495618
50mRNA surveillance pathway_Homo sapiens_hsa030151.09298297
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07779409
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05766604
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00971795
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00120870
55Estrogen signaling pathway_Homo sapiens_hsa049150.99974271
56ErbB signaling pathway_Homo sapiens_hsa040120.98479971
57cAMP signaling pathway_Homo sapiens_hsa040240.96912916
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96803320
59Ether lipid metabolism_Homo sapiens_hsa005650.95007654
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92550326
61Type II diabetes mellitus_Homo sapiens_hsa049300.91124437
62Basal transcription factors_Homo sapiens_hsa030220.90776033
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89237131
64Huntingtons disease_Homo sapiens_hsa050160.85146344
65Shigellosis_Homo sapiens_hsa051310.84550970
66Salmonella infection_Homo sapiens_hsa051320.82784484
67Glioma_Homo sapiens_hsa052140.80832313
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79401995
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78699065
70Melanogenesis_Homo sapiens_hsa049160.77069990
71Phototransduction_Homo sapiens_hsa047440.75556156
72Linoleic acid metabolism_Homo sapiens_hsa005910.75464888
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73658663
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73463419
75Selenocompound metabolism_Homo sapiens_hsa004500.70724826
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69342034
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.68273473
78AMPK signaling pathway_Homo sapiens_hsa041520.68125784
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68111894
80Rheumatoid arthritis_Homo sapiens_hsa053230.67624327
81Fanconi anemia pathway_Homo sapiens_hsa034600.65300891
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65163929
83Propanoate metabolism_Homo sapiens_hsa006400.63621383
84Phagosome_Homo sapiens_hsa041450.63459209
85Fatty acid biosynthesis_Homo sapiens_hsa000610.62186755
86ABC transporters_Homo sapiens_hsa020100.61226111
87Caffeine metabolism_Homo sapiens_hsa002320.60172308
88Peroxisome_Homo sapiens_hsa041460.59986480
89Alcoholism_Homo sapiens_hsa050340.59971424
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59853839
91Dilated cardiomyopathy_Homo sapiens_hsa054140.59516240
92MAPK signaling pathway_Homo sapiens_hsa040100.58068531
93Purine metabolism_Homo sapiens_hsa002300.56862714
94Oocyte meiosis_Homo sapiens_hsa041140.55095963
95Thyroid hormone synthesis_Homo sapiens_hsa049180.54790155
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54199350
97Regulation of autophagy_Homo sapiens_hsa041400.52632537
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52506612
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50271239
100Glucagon signaling pathway_Homo sapiens_hsa049220.50142230
101Prion diseases_Homo sapiens_hsa050200.49489492
102Ras signaling pathway_Homo sapiens_hsa040140.48504346
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48435983
104Colorectal cancer_Homo sapiens_hsa052100.45927933
105Pancreatic secretion_Homo sapiens_hsa049720.45889507
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45805969
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.45477725
108Endometrial cancer_Homo sapiens_hsa052130.43818438
109Choline metabolism in cancer_Homo sapiens_hsa052310.42245200
110Renal cell carcinoma_Homo sapiens_hsa052110.42109866
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41378125
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40583929
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40415149
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40329180
115Wnt signaling pathway_Homo sapiens_hsa043100.40119129
116Pyruvate metabolism_Homo sapiens_hsa006200.39422155
117Sulfur metabolism_Homo sapiens_hsa009200.38283592
118Dorso-ventral axis formation_Homo sapiens_hsa043200.38161671
119RNA polymerase_Homo sapiens_hsa030200.36731374
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36406388
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35358394
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35149536
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.34158336
124Rap1 signaling pathway_Homo sapiens_hsa040150.32519335
125Metabolic pathways_Homo sapiens_hsa011000.32357010
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31746684
127RNA degradation_Homo sapiens_hsa030180.31005557
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.29394093
129Melanoma_Homo sapiens_hsa052180.28897321
130Endocytosis_Homo sapiens_hsa041440.28005274
131Insulin signaling pathway_Homo sapiens_hsa049100.27999150
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26996063
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26705062
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.26613759
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24830422
136Ovarian steroidogenesis_Homo sapiens_hsa049130.23576244
137Retinol metabolism_Homo sapiens_hsa008300.22730150
138Non-homologous end-joining_Homo sapiens_hsa034500.22613869
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22340059
140Spliceosome_Homo sapiens_hsa030400.21813811
141Base excision repair_Homo sapiens_hsa034100.21274971
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21178765
143Hedgehog signaling pathway_Homo sapiens_hsa043400.20970303

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