NXPH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.40538328
2vocalization behavior (GO:0071625)5.81006878
3regulation of synaptic vesicle exocytosis (GO:2000300)5.59580379
4gamma-aminobutyric acid transport (GO:0015812)5.56583186
5synaptic vesicle exocytosis (GO:0016079)5.54749332
6synaptic vesicle maturation (GO:0016188)5.31456304
7nucleobase catabolic process (GO:0046113)5.18041235
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15730648
9neuron cell-cell adhesion (GO:0007158)5.12100536
10glutamate secretion (GO:0014047)5.10028170
11regulation of glutamate receptor signaling pathway (GO:1900449)4.78562288
12neurotransmitter-gated ion channel clustering (GO:0072578)4.71023582
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.70158157
14regulation of synaptic vesicle transport (GO:1902803)4.69402648
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66741385
16locomotory exploration behavior (GO:0035641)4.64276532
17neurotransmitter secretion (GO:0007269)4.63576009
18layer formation in cerebral cortex (GO:0021819)4.59618467
19cerebral cortex radially oriented cell migration (GO:0021799)4.56173841
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.54375604
21proline transport (GO:0015824)4.53566372
22substrate-independent telencephalic tangential migration (GO:0021826)4.52307243
23substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.52307243
24postsynaptic membrane organization (GO:0001941)4.51450075
25protein localization to cilium (GO:0061512)4.43379293
26protein localization to synapse (GO:0035418)4.42021279
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38226713
28cullin deneddylation (GO:0010388)4.37474755
29exploration behavior (GO:0035640)4.35173414
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.28581078
31positive regulation of synapse maturation (GO:0090129)4.16541303
32neuron recognition (GO:0008038)4.11431136
33protein deneddylation (GO:0000338)4.09549054
34neuron-neuron synaptic transmission (GO:0007270)4.07199803
35presynaptic membrane assembly (GO:0097105)4.06778381
36righting reflex (GO:0060013)4.06385170
37regulation of synapse structural plasticity (GO:0051823)4.06176469
38synaptic vesicle docking involved in exocytosis (GO:0016081)4.05459398
39negative regulation of neurotransmitter transport (GO:0051589)4.04423666
40protein-cofactor linkage (GO:0018065)4.00737919
41DNA double-strand break processing (GO:0000729)3.99694092
42synaptic transmission, glutamatergic (GO:0035249)3.90535854
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.87929924
44dendrite morphogenesis (GO:0048813)3.86109185
45positive regulation of mitochondrial fission (GO:0090141)3.72789970
46presynaptic membrane organization (GO:0097090)3.72434233
47establishment of mitochondrion localization (GO:0051654)3.67812765
48NADH metabolic process (GO:0006734)3.67664080
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.63735316
50activation of protein kinase A activity (GO:0034199)3.63218317
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.62202658
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58559975
53negative regulation of neurotransmitter secretion (GO:0046929)3.56950747
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.56408333
55sequestering of actin monomers (GO:0042989)3.55533380
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55498171
57cell migration in hindbrain (GO:0021535)3.53484379
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.52336256
59clathrin coat assembly (GO:0048268)3.51679599
60neuronal action potential propagation (GO:0019227)3.48356824
61mitochondrion transport along microtubule (GO:0047497)3.47355983
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.47355983
63regulation of cAMP-dependent protein kinase activity (GO:2000479)3.47218978
64neurotransmitter transport (GO:0006836)3.46088713
65DNA damage response, detection of DNA damage (GO:0042769)3.43970916
66cardiac ventricle formation (GO:0003211)3.43643374
67startle response (GO:0001964)3.43306603
68regulation of synaptic transmission, GABAergic (GO:0032228)3.42588875
69transferrin transport (GO:0033572)3.41831172
70regulation of synapse maturation (GO:0090128)3.41080306
71central nervous system projection neuron axonogenesis (GO:0021952)3.38995156
72cardiac chamber formation (GO:0003207)3.37779505
73regulation of neuronal synaptic plasticity (GO:0048168)3.37207756
74limb bud formation (GO:0060174)3.36909747
75axonal fasciculation (GO:0007413)3.36899045
76long-term memory (GO:0007616)3.31523980
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.30854044
78ATP hydrolysis coupled proton transport (GO:0015991)3.30854044
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.29856520
80regulation of cofactor metabolic process (GO:0051193)3.29512367
81regulation of coenzyme metabolic process (GO:0051196)3.29512367
82regulation of neurotransmitter levels (GO:0001505)3.28632567
83histone H2A acetylation (GO:0043968)3.27654642
84axon extension (GO:0048675)3.27069910
85glutamate receptor signaling pathway (GO:0007215)3.26520147
86striatum development (GO:0021756)3.25927677
87long-term synaptic potentiation (GO:0060291)3.25529018
88oxaloacetate metabolic process (GO:0006107)3.21632338
89negative regulation of DNA recombination (GO:0045910)3.20049010
90regulation of neurotransmitter secretion (GO:0046928)3.17021129
91ferric iron transport (GO:0015682)3.16619373
92trivalent inorganic cation transport (GO:0072512)3.16619373
93succinate metabolic process (GO:0006105)3.15998951
94regulation of neurotransmitter transport (GO:0051588)3.15674287
95exogenous drug catabolic process (GO:0042738)3.15055931
96regulation of female receptivity (GO:0045924)3.14467106
97microtubule depolymerization (GO:0007019)3.13664501
98regulation of double-strand break repair via homologous recombination (GO:0010569)3.13062304
99regulation of neurotransmitter uptake (GO:0051580)3.12386384
100peptidyl-cysteine modification (GO:0018198)3.11635154
101female mating behavior (GO:0060180)3.05643021
102L-serine transport (GO:0015825)3.04543182
103negative regulation of telomere maintenance (GO:0032205)3.02603800
104regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00739510
105microtubule polymerization or depolymerization (GO:0031109)2.99428984
106synapse assembly (GO:0007416)2.99143690
107positive regulation of neurotransmitter transport (GO:0051590)2.98896455
108dendritic spine morphogenesis (GO:0060997)2.98879676
109negative regulation of microtubule polymerization (GO:0031115)2.98693327
110cerebral cortex cell migration (GO:0021795)2.98205444
111positive regulation of membrane potential (GO:0045838)2.97059338
112learning (GO:0007612)2.96894232
113regulation of acyl-CoA biosynthetic process (GO:0050812)2.96624853
114regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96555396
115synaptic vesicle endocytosis (GO:0048488)2.94891034
116regulation of synaptic transmission, dopaminergic (GO:0032225)2.94426275
117response to histamine (GO:0034776)2.92622402
118regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.92406160
119transmission of nerve impulse (GO:0019226)2.91379722
120organelle transport along microtubule (GO:0072384)2.90947313
121synaptic transmission (GO:0007268)2.90104681
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88859445
123glycine transport (GO:0015816)2.88659895
124neuron projection extension (GO:1990138)2.87198464
125chaperone-mediated protein transport (GO:0072321)2.84561514
126regulation of synaptic plasticity (GO:0048167)2.83266040
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.83229187
128regulation of development, heterochronic (GO:0040034)2.81587405
129behavioral response to cocaine (GO:0048148)2.78533483
130epithelial cell differentiation involved in kidney development (GO:0035850)2.74878071
131C4-dicarboxylate transport (GO:0015740)2.69864621
132positive regulation of RNA splicing (GO:0033120)2.69266999
133regulation of timing of cell differentiation (GO:0048505)2.68792640
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68250995
135regulation of mitotic spindle checkpoint (GO:1903504)2.68250995
136L-serine metabolic process (GO:0006563)2.68151725
137regulation of telomere maintenance via telomerase (GO:0032210)2.66997387
138reflex (GO:0060004)2.62747003
139DNA replication checkpoint (GO:0000076)2.61695202
140cardiac muscle cell development (GO:0055013)2.58303871
141short-term memory (GO:0007614)2.56518490
142L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56508559
143regulation of centriole replication (GO:0046599)2.55858342
144auditory behavior (GO:0031223)2.52431004
145positive regulation of synapse assembly (GO:0051965)2.51165772
146generation of neurons (GO:0048699)2.50670191
147neuron fate determination (GO:0048664)2.50407648
148behavioral response to ethanol (GO:0048149)2.47180923
149ventricular cardiac muscle cell development (GO:0055015)2.46798399
150behavioral response to nicotine (GO:0035095)2.43977006
151serine transport (GO:0032329)2.43195659
152neural nucleus development (GO:0048857)2.37464869
153regulation of telomere maintenance (GO:0032204)2.36875847
154regulation of mRNA splicing, via spliceosome (GO:0048024)2.36152353
155DNA integration (GO:0015074)2.35721340
156cardiac cell development (GO:0055006)2.35332979
157establishment of integrated proviral latency (GO:0075713)2.34074931
158germ cell migration (GO:0008354)2.33254478
159glycosphingolipid biosynthetic process (GO:0006688)2.33147256
160regulation of mitochondrial fission (GO:0090140)2.30096095
161respiratory chain complex IV assembly (GO:0008535)2.29996626
162glial cell proliferation (GO:0014009)2.29661525
163chromatin remodeling at centromere (GO:0031055)2.27482766
164behavioral defense response (GO:0002209)2.26928475
165behavioral fear response (GO:0001662)2.26928475
166negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.25714668
167cellular component maintenance (GO:0043954)2.25593056
168inner ear receptor cell development (GO:0060119)2.24699455
169de novo protein folding (GO:0006458)2.24583615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.02074366
2GBX2_23144817_ChIP-Seq_PC3_Human4.25170217
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09217063
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99480133
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87548451
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68120040
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.67851507
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.66620113
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58961563
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57625511
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38193790
12AR_21572438_ChIP-Seq_LNCaP_Human2.37730658
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.36733333
14* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33130315
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32827573
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29222673
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.28449473
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28192392
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27998379
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24922929
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23758342
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23758342
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22520968
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20551620
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15190083
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15075018
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09892143
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.08027254
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.06677767
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02888972
31ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00927093
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.97358685
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97222902
34EWS_26573619_Chip-Seq_HEK293_Human1.96490949
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95099609
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.92419778
37* TAF15_26573619_Chip-Seq_HEK293_Human1.92083077
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.90598974
39DROSHA_22980978_ChIP-Seq_HELA_Human1.90440729
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86114863
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83095563
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80973893
43SMAD4_21799915_ChIP-Seq_A2780_Human1.79595165
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75717451
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.74552842
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.73786296
47E2F7_22180533_ChIP-Seq_HELA_Human1.72113162
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71450733
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69814926
50* P300_19829295_ChIP-Seq_ESCs_Human1.69653023
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69614868
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.67939056
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67396472
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65119184
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.58688474
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56234724
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54234402
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.53838285
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.51675672
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48772489
61ZNF274_21170338_ChIP-Seq_K562_Hela1.45926591
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45133002
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44557511
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44026917
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43076808
66FUS_26573619_Chip-Seq_HEK293_Human1.43004524
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42967825
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41166376
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39589958
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.38881022
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37345340
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36680902
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.36234230
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36019498
75AR_25329375_ChIP-Seq_VCAP_Human1.35696018
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35444448
77RNF2_27304074_Chip-Seq_NSC_Mouse1.35091211
78* STAT3_23295773_ChIP-Seq_U87_Human1.31679659
79ELK1_19687146_ChIP-ChIP_HELA_Human1.31211035
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.30879521
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30804546
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29860829
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.29526972
84* PIAS1_25552417_ChIP-Seq_VCAP_Human1.29228532
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28891903
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27293756
87IRF1_19129219_ChIP-ChIP_H3396_Human1.25765258
88MYC_18940864_ChIP-ChIP_HL60_Human1.24989310
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.24240927
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.23367947
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21953929
92TCF4_23295773_ChIP-Seq_U87_Human1.19934848
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18884614
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17310342
95* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17036319
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16320100
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15453195
98TP53_18474530_ChIP-ChIP_U2OS_Human1.14361373
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.14288086
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14080457
101VDR_22108803_ChIP-Seq_LS180_Human1.13870267
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.12796546
103ER_23166858_ChIP-Seq_MCF-7_Human1.12699689
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12523603
105JUN_21703547_ChIP-Seq_K562_Human1.12412768
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11289848
107THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09638487
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09430371
109AHR_22903824_ChIP-Seq_MCF-7_Human1.06985539
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06174626
111AR_19668381_ChIP-Seq_PC3_Human1.06153077
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05580646
113* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05196636
114VDR_23849224_ChIP-Seq_CD4+_Human1.05122836
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.04903441
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.04412660
117ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04139705
118* RUNX2_22187159_ChIP-Seq_PCA_Human1.03869593
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03737574
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03333648
121SOX9_26525672_Chip-Seq_HEART_Mouse1.03310154
122IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02965591
123IGF1R_20145208_ChIP-Seq_DFB_Human1.02090585
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01367482
125TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99750451
126TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99698908
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98658121
128REST_19997604_ChIP-ChIP_NEURONS_Mouse0.98462235
129MYC_18555785_ChIP-Seq_MESCs_Mouse0.97461497
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96671559
131FOXP3_21729870_ChIP-Seq_TREG_Human0.96664176
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96410166
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.96127111
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.95558012
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.95288518
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95093655
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94031057
138CBP_20019798_ChIP-Seq_JUKART_Human0.94031057
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93996547
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93531424
141* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93059181
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.92745564
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92233558
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.92126458
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91943832
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91943832
147GABP_19822575_ChIP-Seq_HepG2_Human0.91051526
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90438038
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89591936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.71810366
2MP0003635_abnormal_synaptic_transmissio4.00348411
3MP0009046_muscle_twitch3.39504842
4MP0003880_abnormal_central_pattern3.37735636
5MP0009745_abnormal_behavioral_response3.35943323
6MP0004270_analgesia3.34123703
7MP0002063_abnormal_learning/memory/cond3.28582234
8MP0002064_seizures3.04178299
9MP0001188_hyperpigmentation2.79877209
10MP0004858_abnormal_nervous_system2.74622354
11MP0002572_abnormal_emotion/affect_behav2.73629344
12MP0003646_muscle_fatigue2.65525907
13MP0001968_abnormal_touch/_nociception2.62739329
14MP0002736_abnormal_nociception_after2.58264665
15MP0002734_abnormal_mechanical_nocicepti2.43198296
16MP0001501_abnormal_sleep_pattern2.40312392
17MP0009780_abnormal_chondrocyte_physiolo2.29598063
18MP0003121_genomic_imprinting2.22642574
19MP0002735_abnormal_chemical_nociception2.21027683
20MP0002272_abnormal_nervous_system2.19056460
21MP0000778_abnormal_nervous_system2.14647840
22MP0001486_abnormal_startle_reflex2.14466191
23MP0001440_abnormal_grooming_behavior2.13210384
24MP0004811_abnormal_neuron_physiology2.09913421
25MP0004233_abnormal_muscle_weight2.09522359
26MP0005423_abnormal_somatic_nervous2.07934400
27MP0005645_abnormal_hypothalamus_physiol2.06341515
28MP0002184_abnormal_innervation2.06017503
29MP0002733_abnormal_thermal_nociception1.92956486
30MP0003567_abnormal_fetal_cardiomyocyte1.88462535
31MP0002557_abnormal_social/conspecific_i1.88132818
32MP0002233_abnormal_nose_morphology1.79137020
33MP0001970_abnormal_pain_threshold1.78429797
34MP0003787_abnormal_imprinting1.75414982
35MP0005386_behavior/neurological_phenoty1.75245887
36MP0004924_abnormal_behavior1.75245887
37MP0006276_abnormal_autonomic_nervous1.71261408
38MP0008058_abnormal_DNA_repair1.68881209
39MP0002067_abnormal_sensory_capabilities1.68209648
40MP0008569_lethality_at_weaning1.66471803
41MP0002638_abnormal_pupillary_reflex1.65995522
42MP0005646_abnormal_pituitary_gland1.65662568
43MP0000955_abnormal_spinal_cord1.61676686
44MP0001348_abnormal_lacrimal_gland1.57540194
45MP0000566_synostosis1.53791997
46MP0003879_abnormal_hair_cell1.51701566
47MP0000049_abnormal_middle_ear1.51256542
48MP0003122_maternal_imprinting1.51038315
49MP0001293_anophthalmia1.47897617
50MP0003941_abnormal_skin_development1.46511036
51MP0002876_abnormal_thyroid_physiology1.45077617
52MP0002909_abnormal_adrenal_gland1.44728672
53MP0001529_abnormal_vocalization1.40627102
54MP0001299_abnormal_eye_distance/1.40090075
55MP0002697_abnormal_eye_size1.39801204
56MP0000013_abnormal_adipose_tissue1.39764793
57MP0002066_abnormal_motor_capabilities/c1.39185756
58MP0002882_abnormal_neuron_morphology1.38849458
59MP0003329_amyloid_beta_deposits1.38597321
60MP0004142_abnormal_muscle_tone1.36730762
61MP0009697_abnormal_copulation1.33879579
62MP0003385_abnormal_body_wall1.32461833
63MP0001984_abnormal_olfaction1.31142223
64MP0003221_abnormal_cardiomyocyte_apopto1.30820526
65MP0003938_abnormal_ear_development1.26177295
66MP0002751_abnormal_autonomic_nervous1.26003225
67MP0010094_abnormal_chromosome_stability1.24477644
68MP0005394_taste/olfaction_phenotype1.22455112
69MP0005499_abnormal_olfactory_system1.22455112
70MP0000569_abnormal_digit_pigmentation1.22361798
71MP0003283_abnormal_digestive_organ1.22101357
72MP0002152_abnormal_brain_morphology1.20056570
73MP0004133_heterotaxia1.16333896
74MP0006035_abnormal_mitochondrial_morpho1.15889024
75MP0003937_abnormal_limbs/digits/tail_de1.14031562
76MP0000631_abnormal_neuroendocrine_gland1.13804982
77MP0002837_dystrophic_cardiac_calcinosis1.13701334
78MP0001905_abnormal_dopamine_level1.07145599
79MP0008932_abnormal_embryonic_tissue1.05921592
80MP0006072_abnormal_retinal_apoptosis1.05627928
81MP0002090_abnormal_vision1.04474389
82MP0001346_abnormal_lacrimal_gland1.03877908
83MP0004885_abnormal_endolymph1.03182654
84MP0001286_abnormal_eye_development1.02947799
85MP0006292_abnormal_olfactory_placode1.02434546
86MP0008872_abnormal_physiological_respon1.02031294
87MP0003755_abnormal_palate_morphology1.02005792
88MP0003890_abnormal_embryonic-extraembry1.01263669
89MP0003111_abnormal_nucleus_morphology0.98819506
90MP0004085_abnormal_heartbeat0.97594354
91MP0002069_abnormal_eating/drinking_beha0.97484374
92MP0008789_abnormal_olfactory_epithelium0.96504801
93MP0003633_abnormal_nervous_system0.95309859
94MP0002102_abnormal_ear_morphology0.90905530
95MP0004484_altered_response_of0.90043277
96MP0004742_abnormal_vestibular_system0.89027824
97MP0005084_abnormal_gallbladder_morpholo0.88860084
98MP0000751_myopathy0.88115245
99MP0009672_abnormal_birth_weight0.87740901
100MP0005623_abnormal_meninges_morphology0.87631535
101MP0003631_nervous_system_phenotype0.87443805
102MP0002234_abnormal_pharynx_morphology0.87237817
103MP0001986_abnormal_taste_sensitivity0.86749101
104MP0001177_atelectasis0.84261268
105MP0002177_abnormal_outer_ear0.83704457
106MP0004197_abnormal_fetal_growth/weight/0.83617816
107MP0005187_abnormal_penis_morphology0.83503975
108MP0004130_abnormal_muscle_cell0.81245220
109MP0002229_neurodegeneration0.80579623
110MP0004043_abnormal_pH_regulation0.79607222
111MP0003136_yellow_coat_color0.79289542
112MP0002081_perinatal_lethality0.79260582
113MP0001963_abnormal_hearing_physiology0.78239691
114MP0010386_abnormal_urinary_bladder0.78221675
115MP0005248_abnormal_Harderian_gland0.78167961
116MP0000537_abnormal_urethra_morphology0.77588043
117MP0003303_peritoneal_inflammation0.76034904
118MP0001664_abnormal_digestion0.74155907
119MP0002752_abnormal_somatic_nervous0.74038257
120MP0004215_abnormal_myocardial_fiber0.72413320
121MP0000026_abnormal_inner_ear0.72035521
122MP0003861_abnormal_nervous_system0.71263678
123MP0005391_vision/eye_phenotype0.70610028
124MP0003077_abnormal_cell_cycle0.68903925
125MP0008877_abnormal_DNA_methylation0.68861445
126MP0003634_abnormal_glial_cell0.65802206
127MP0003119_abnormal_digestive_system0.65730319
128MP0003632_abnormal_nervous_system0.65541606
129MP0004036_abnormal_muscle_relaxation0.61742157
130MP0001502_abnormal_circadian_rhythm0.61061771
131MP0005535_abnormal_body_temperature0.59108192
132MP0010770_preweaning_lethality0.58601265
133MP0002082_postnatal_lethality0.58601265
134MP0008874_decreased_physiological_sensi0.56963961
135MP0010769_abnormal_survival0.56649482
136MP0003137_abnormal_impulse_conducting0.54471826
137MP0004084_abnormal_cardiac_muscle0.54061906
138MP0005410_abnormal_fertilization0.53848945
139MP0002822_catalepsy0.52932487
140MP0000604_amyloidosis0.52324273
141MP0005551_abnormal_eye_electrophysiolog0.51692322
142MP0010768_mortality/aging0.51677964

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.75842055
2Atonic seizures (HP:0010819)4.74850693
3Febrile seizures (HP:0002373)4.54395122
4Epileptic encephalopathy (HP:0200134)4.49934541
5Myokymia (HP:0002411)4.36623186
6Absent eyebrow (HP:0002223)4.31777924
7Focal seizures (HP:0007359)4.29807159
8Akinesia (HP:0002304)4.06304498
9Absence seizures (HP:0002121)3.84698747
10Microvesicular hepatic steatosis (HP:0001414)3.70590128
11Hyperventilation (HP:0002883)3.69548438
12Pheochromocytoma (HP:0002666)3.69044110
13Visual hallucinations (HP:0002367)3.61711435
14Polyphagia (HP:0002591)3.50166364
15Absent eyelashes (HP:0000561)3.49042871
16Neuroendocrine neoplasm (HP:0100634)3.42537246
17Mutism (HP:0002300)3.37555058
18Progressive inability to walk (HP:0002505)3.30329288
19Gait imbalance (HP:0002141)3.24983598
20Limb dystonia (HP:0002451)3.24877146
21Abnormality of binocular vision (HP:0011514)3.21280477
22Diplopia (HP:0000651)3.21280477
23Generalized tonic-clonic seizures (HP:0002069)3.20128414
24Split foot (HP:0001839)3.19511094
25Dialeptic seizures (HP:0011146)3.19493629
26Progressive cerebellar ataxia (HP:0002073)3.03709025
27Poor eye contact (HP:0000817)2.99698668
28Abnormal social behavior (HP:0012433)2.90024741
29Impaired social interactions (HP:0000735)2.90024741
30Amyotrophic lateral sclerosis (HP:0007354)2.89274936
31Abnormal hair whorl (HP:0010721)2.88373949
32Abnormal eating behavior (HP:0100738)2.87901854
33Broad-based gait (HP:0002136)2.86933640
34Inability to walk (HP:0002540)2.84832174
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.82801862
36Poor suck (HP:0002033)2.77437211
37Lissencephaly (HP:0001339)2.76576138
38Supranuclear gaze palsy (HP:0000605)2.76415956
39Epileptiform EEG discharges (HP:0011182)2.75108813
40Stereotypic behavior (HP:0000733)2.72786448
41Drooling (HP:0002307)2.69042458
42Excessive salivation (HP:0003781)2.69042458
43EEG with generalized epileptiform discharges (HP:0011198)2.68286395
44Ankle clonus (HP:0011448)2.65956903
45Protruding tongue (HP:0010808)2.65441958
46Hypsarrhythmia (HP:0002521)2.63705405
47Focal dystonia (HP:0004373)2.62452179
48Abnormality of the corticospinal tract (HP:0002492)2.52812698
49Craniofacial dystonia (HP:0012179)2.44580222
50Rimmed vacuoles (HP:0003805)2.41117571
51Shoulder girdle muscle weakness (HP:0003547)2.40631965
52Depression (HP:0000716)2.40495905
53Bradykinesia (HP:0002067)2.40255181
54Papillary thyroid carcinoma (HP:0002895)2.36313029
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.32993417
56Hypoplasia of the brainstem (HP:0002365)2.32993417
57Decreased muscle mass (HP:0003199)2.32941855
58Vaginal atresia (HP:0000148)2.32645368
59Papilledema (HP:0001085)2.31716577
60Fibular aplasia (HP:0002990)2.30343173
61Torticollis (HP:0000473)2.29023171
62Urinary bladder sphincter dysfunction (HP:0002839)2.28001490
63Impaired vibration sensation in the lower limbs (HP:0002166)2.27686649
64Colon cancer (HP:0003003)2.27538994
65Genital tract atresia (HP:0001827)2.27431006
66Pachygyria (HP:0001302)2.27173560
67Abnormality of the hip-girdle musculature (HP:0001445)2.25353320
68Abnormality of the musculature of the pelvis (HP:0001469)2.25353320
69Relative macrocephaly (HP:0004482)2.25254897
70Congenital primary aphakia (HP:0007707)2.25011338
71Esotropia (HP:0000565)2.24717908
72Inappropriate behavior (HP:0000719)2.23951304
73Medulloblastoma (HP:0002885)2.22786372
74Neoplasm of the peripheral nervous system (HP:0100007)2.22449516
75Delayed CNS myelination (HP:0002188)2.22037050
76Generalized myoclonic seizures (HP:0002123)2.21198667
77Humeroradial synostosis (HP:0003041)2.21107552
78Synostosis involving the elbow (HP:0003938)2.21107552
79Partial agenesis of the corpus callosum (HP:0001338)2.18909470
80Sleep apnea (HP:0010535)2.17592863
81Anxiety (HP:0000739)2.17313657
82Chromsome breakage (HP:0040012)2.16183569
83Optic nerve coloboma (HP:0000588)2.15852342
84Action tremor (HP:0002345)2.15494948
85Abnormality of the labia minora (HP:0012880)2.15123235
86Specific learning disability (HP:0001328)2.14988740
87Termporal pattern (HP:0011008)2.14809449
88Insidious onset (HP:0003587)2.14809449
89Scrotal hypoplasia (HP:0000046)2.13615909
90Progressive microcephaly (HP:0000253)2.13558431
91Spastic tetraplegia (HP:0002510)2.13540729
92Genetic anticipation (HP:0003743)2.13504035
93Truncal ataxia (HP:0002078)2.13451121
94Cutaneous syndactyly (HP:0012725)2.12387867
95Peripheral hypomyelination (HP:0007182)2.12138867
96Failure to thrive in infancy (HP:0001531)2.10781935
97Open mouth (HP:0000194)2.10681976
98Trigonocephaly (HP:0000243)2.10021514
99Hyperglycinemia (HP:0002154)2.09939745
100Nephrogenic diabetes insipidus (HP:0009806)2.09432593
101Apathy (HP:0000741)2.07555549
102Abnormality of alanine metabolism (HP:0010916)2.07511752
103Hyperalaninemia (HP:0003348)2.07511752
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07511752
105Medial flaring of the eyebrow (HP:0010747)2.07386660
106Urinary urgency (HP:0000012)2.07215235
107Cortical dysplasia (HP:0002539)2.07007956
108Thickened helices (HP:0000391)2.05851165
109Short tibia (HP:0005736)2.05259045
110Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04388249
111Hemiparesis (HP:0001269)2.03126001
112Absent speech (HP:0001344)2.03002314
113Upper limb muscle weakness (HP:0003484)2.02912750
114Ependymoma (HP:0002888)2.02827078
115Spastic gait (HP:0002064)2.01228092
116Athetosis (HP:0002305)2.00411357
117Pelvic girdle muscle weakness (HP:0003749)2.00185123
118Hepatocellular necrosis (HP:0001404)1.99872027
119Intellectual disability, profound (HP:0002187)1.99047649
120Abnormality of the antihelix (HP:0009738)1.98305893
121Acute necrotizing encephalopathy (HP:0006965)1.97714654
122Ulnar claw (HP:0001178)1.97698856
123Morphological abnormality of the middle ear (HP:0008609)1.96839049
124Complete atrioventricular canal defect (HP:0001674)1.96777245
125Abnormality of the lower motor neuron (HP:0002366)1.96553573
126Gastroesophageal reflux (HP:0002020)1.96043319
127Diminished movement (HP:0002374)1.95032643
128Abnormal mitochondria in muscle tissue (HP:0008316)1.94947014
129Bilateral microphthalmos (HP:0007633)1.94822630
130Status epilepticus (HP:0002133)1.93216339
131Intellectual disability, moderate (HP:0002342)1.93039863
132Thyroid-stimulating hormone excess (HP:0002925)1.92373340
133Fetal akinesia sequence (HP:0001989)1.91275895
134Chorioretinal coloboma (HP:0000567)1.91260762
135Dysdiadochokinesis (HP:0002075)1.89861970
136Patellar aplasia (HP:0006443)1.89793854
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.89540609
138Retinal dysplasia (HP:0007973)1.88952651
139Agitation (HP:0000713)1.86707472
140Cutaneous finger syndactyly (HP:0010554)1.85514193
141Pendular nystagmus (HP:0012043)1.83897507
142Hypothermia (HP:0002045)1.82146740
143Anophthalmia (HP:0000528)1.80787779
144Abnormal lung lobation (HP:0002101)1.78942044
145Decreased testicular size (HP:0008734)1.78680145
146Preaxial hand polydactyly (HP:0001177)1.78540230
147Myelomeningocele (HP:0002475)1.77689095
148Tubulointerstitial nephritis (HP:0001970)1.76756719
149Meckel diverticulum (HP:0002245)1.76592643
150Abnormality of the metopic suture (HP:0005556)1.76501056
151Glioma (HP:0009733)1.75039984
152Large earlobe (HP:0009748)1.74558567
153Micropenis (HP:0000054)1.73967512
154Nephronophthisis (HP:0000090)1.73586009
155Growth hormone deficiency (HP:0000824)1.73396145
156Abnormality of glycolysis (HP:0004366)1.73161593
157Atrophy/Degeneration involving motor neurons (HP:0007373)1.72002559
158Increased serum pyruvate (HP:0003542)1.70336074
159Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69698173
160Bicornuate uterus (HP:0000813)1.69461230
161Generalized hypotonia (HP:0001290)1.68481011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK17.04906332
2AKT35.21576893
3MAP2K73.36285296
4MAP3K43.23862332
5NTRK32.95404930
6BCR2.86357428
7TRIM282.85962205
8MAP4K22.84890295
9MAP3K92.83630766
10PLK42.52048519
11PDK42.51423375
12PDK32.51423375
13SRPK12.48050814
14LATS12.35923886
15NTRK22.31368405
16MINK12.30820703
17ZAK2.22235569
18CDC72.22028156
19CASK2.11938398
20PKN22.04480253
21MAP2K41.86923681
22MAP3K121.81886399
23DYRK21.81708797
24BRAF1.70356397
25PHKG11.66331692
26PHKG21.66331692
27MAPK131.63152047
28MKNK11.62789989
29PLK21.62408064
30PDK21.48837548
31DAPK21.47367531
32CSNK1G11.46158124
33CDK81.44878230
34LATS21.44494955
35PLK31.44120767
36NUAK11.43421417
37SGK21.41616123
38TSSK61.39794628
39FLT31.34111615
40SCYL21.33076791
41ERBB31.23631475
42CDK51.22351018
43STK161.22249319
44DAPK11.20197587
45SGK4941.19616663
46SGK2231.19616663
47PRKCG1.18519932
48CCNB11.18077833
49TTK1.17780573
50EPHA41.17652108
51ERBB41.15868873
52BMPR1B1.11551372
53BUB11.10712202
54PAK61.07984076
55CAMKK11.04237234
56SGK31.02794715
57CSNK1G21.00905170
58STK38L0.98763660
59GRK50.97110402
60PRPF4B0.96903906
61KSR10.91105813
62IRAK20.88458025
63ATR0.88050848
64PLK10.86252615
65MAP3K20.84690466
66EPHA30.83690658
67NTRK10.82926098
68LIMK10.82757078
69NME10.82709948
70NEK10.82594017
71CAMK2A0.81662689
72DYRK30.81011832
73CDK190.80713849
74OBSCN0.79335752
75MAP3K110.77553207
76MAP2K60.75523913
77KSR20.75384596
78PKN10.73648447
79PRKCE0.70907975
80DYRK1A0.68616277
81UHMK10.68266222
82PRKCH0.68154798
83ALK0.66382067
84RPS6KA20.66376034
85RPS6KA40.65373923
86TNIK0.65086455
87CDK180.64552899
88CDK140.62867973
89PINK10.62770787
90EIF2AK20.62290538
91CDK150.62097217
92CAMK10.59561126
93MAP3K60.59386834
94MAPK120.59092739
95BRSK20.59017753
96MAPKAPK30.58500224
97PRKCZ0.57569416
98TIE10.57368476
99PNCK0.56140074
100MARK20.54946335
101MAP3K50.54896399
102SGK10.54250581
103PAK30.52404940
104CAMK40.52184825
105SIK20.50632251
106CDK11A0.50260235
107ATM0.50009953
108RET0.48385859
109FES0.48325979
110CAMK2B0.47999277
111CSNK1E0.47346827
112RPS6KB10.46831769
113IRAK10.43994115
114PRKD30.43952680
115CSNK1G30.43179291
116GRK70.42714009
117SIK30.40907118
118WNK30.40495747
119FYN0.37812043
120PRKDC0.37322667
121WEE10.37315350
122MAP2K10.37295276
123OXSR10.36464536
124MAPK90.36442218
125RPS6KA30.35830175
126EPHB20.35343116
127CSNK1A10.34526425
128BRSK10.34479301
129CSNK1D0.33855969
130PRKG10.33059589
131MKNK20.30707963
132CDK90.30178331
133TGFBR10.30023196
134PRKCB0.29774177
135VRK10.29177367
136AURKB0.29125886
137STK110.27824894
138CSNK1A1L0.27641292
139CAMK2G0.26696228
140CAMKK20.26128208
141LMTK20.25729810
142TESK10.24499499
143PRKACG0.24260076
144PRKACA0.23525499
145MAPK80.23024612
146PDK10.22969196

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80290828
2Synaptic vesicle cycle_Homo sapiens_hsa047213.76687644
3GABAergic synapse_Homo sapiens_hsa047272.84686736
4Collecting duct acid secretion_Homo sapiens_hsa049662.69195139
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60715679
6Protein export_Homo sapiens_hsa030602.52276563
7Circadian entrainment_Homo sapiens_hsa047132.42793360
8Morphine addiction_Homo sapiens_hsa050322.38876807
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37793118
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28949944
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28244738
12Olfactory transduction_Homo sapiens_hsa047402.25891781
13Long-term potentiation_Homo sapiens_hsa047202.22573835
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14402946
15Dopaminergic synapse_Homo sapiens_hsa047282.04982240
16Non-homologous end-joining_Homo sapiens_hsa034502.03752161
17Glutamatergic synapse_Homo sapiens_hsa047241.98412600
18Selenocompound metabolism_Homo sapiens_hsa004501.94647780
19Mismatch repair_Homo sapiens_hsa034301.88940491
20Vibrio cholerae infection_Homo sapiens_hsa051101.83945490
21Proteasome_Homo sapiens_hsa030501.80369651
22Amphetamine addiction_Homo sapiens_hsa050311.72772120
23Long-term depression_Homo sapiens_hsa047301.70144012
24DNA replication_Homo sapiens_hsa030301.67604779
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66988410
26Serotonergic synapse_Homo sapiens_hsa047261.63935091
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58699978
28Salivary secretion_Homo sapiens_hsa049701.58540542
29Spliceosome_Homo sapiens_hsa030401.57276812
30Cholinergic synapse_Homo sapiens_hsa047251.53540601
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53421090
32Taste transduction_Homo sapiens_hsa047421.53152781
33Basal transcription factors_Homo sapiens_hsa030221.48964117
34mRNA surveillance pathway_Homo sapiens_hsa030151.47753670
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45643321
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43923395
37Axon guidance_Homo sapiens_hsa043601.41164545
38RNA transport_Homo sapiens_hsa030131.40654244
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39645056
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39243900
41Renin secretion_Homo sapiens_hsa049241.38552612
42Base excision repair_Homo sapiens_hsa034101.38483767
43Biosynthesis of amino acids_Homo sapiens_hsa012301.37892390
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34251559
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33436096
46Oxidative phosphorylation_Homo sapiens_hsa001901.33349621
47Insulin secretion_Homo sapiens_hsa049111.32872184
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31256777
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29037375
50RNA degradation_Homo sapiens_hsa030181.28546929
51Cell cycle_Homo sapiens_hsa041101.25078482
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22193375
53Pyruvate metabolism_Homo sapiens_hsa006201.21934142
54Fanconi anemia pathway_Homo sapiens_hsa034601.19973024
55ErbB signaling pathway_Homo sapiens_hsa040121.16036684
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15418562
57Fatty acid elongation_Homo sapiens_hsa000621.13489838
58Butanoate metabolism_Homo sapiens_hsa006501.13283256
59Calcium signaling pathway_Homo sapiens_hsa040201.13203216
60Hippo signaling pathway_Homo sapiens_hsa043901.12594769
61Gap junction_Homo sapiens_hsa045401.12456922
62Gastric acid secretion_Homo sapiens_hsa049711.12234823
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11402854
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11092262
65Cocaine addiction_Homo sapiens_hsa050301.07813474
66Oxytocin signaling pathway_Homo sapiens_hsa049211.07563770
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05452014
68Parkinsons disease_Homo sapiens_hsa050120.99831101
69Alzheimers disease_Homo sapiens_hsa050100.99677224
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99535764
71Type II diabetes mellitus_Homo sapiens_hsa049300.95569559
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93121419
73Propanoate metabolism_Homo sapiens_hsa006400.91752939
74Estrogen signaling pathway_Homo sapiens_hsa049150.90252535
75cAMP signaling pathway_Homo sapiens_hsa040240.87930969
76beta-Alanine metabolism_Homo sapiens_hsa004100.87907488
77Endometrial cancer_Homo sapiens_hsa052130.87545295
78Tight junction_Homo sapiens_hsa045300.86936789
79Colorectal cancer_Homo sapiens_hsa052100.86302396
80Glioma_Homo sapiens_hsa052140.85482438
81Arginine biosynthesis_Homo sapiens_hsa002200.84572129
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84468080
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82506271
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80701779
85Melanogenesis_Homo sapiens_hsa049160.79562497
86Type I diabetes mellitus_Homo sapiens_hsa049400.78516111
87Regulation of autophagy_Homo sapiens_hsa041400.78114338
88Homologous recombination_Homo sapiens_hsa034400.77978032
89Ether lipid metabolism_Homo sapiens_hsa005650.77951871
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77350836
91Renal cell carcinoma_Homo sapiens_hsa052110.76931354
92GnRH signaling pathway_Homo sapiens_hsa049120.76640975
93Pancreatic secretion_Homo sapiens_hsa049720.75393989
94Huntingtons disease_Homo sapiens_hsa050160.74514353
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72980805
96Arginine and proline metabolism_Homo sapiens_hsa003300.72720629
97Nucleotide excision repair_Homo sapiens_hsa034200.72139007
98Phagosome_Homo sapiens_hsa041450.71308695
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70636248
100Sulfur metabolism_Homo sapiens_hsa009200.69471039
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68718216
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68084965
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65637414
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63453982
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63251233
106Glucagon signaling pathway_Homo sapiens_hsa049220.62550641
107Hedgehog signaling pathway_Homo sapiens_hsa043400.62382166
108Steroid biosynthesis_Homo sapiens_hsa001000.62078440
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61973750
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61464631
111Purine metabolism_Homo sapiens_hsa002300.61431821
112Rheumatoid arthritis_Homo sapiens_hsa053230.61299674
113One carbon pool by folate_Homo sapiens_hsa006700.60124954
114Cardiac muscle contraction_Homo sapiens_hsa042600.59764103
115RNA polymerase_Homo sapiens_hsa030200.57723433
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57677427
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57595944
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.56773666
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55793694
120Insulin signaling pathway_Homo sapiens_hsa049100.55005867
121MAPK signaling pathway_Homo sapiens_hsa040100.52363000
122TGF-beta signaling pathway_Homo sapiens_hsa043500.52117632
123Oocyte meiosis_Homo sapiens_hsa041140.52026579
124Phototransduction_Homo sapiens_hsa047440.51111117
125Pyrimidine metabolism_Homo sapiens_hsa002400.48813969
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48105107
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.47734947
128Alcoholism_Homo sapiens_hsa050340.47614702
129Sulfur relay system_Homo sapiens_hsa041220.47204191
130Basal cell carcinoma_Homo sapiens_hsa052170.44292302
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40705058
132Ras signaling pathway_Homo sapiens_hsa040140.38398100
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38145934
134mTOR signaling pathway_Homo sapiens_hsa041500.37704405
135Vitamin B6 metabolism_Homo sapiens_hsa007500.37050219
136Melanoma_Homo sapiens_hsa052180.36359760
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.36209558
138Prion diseases_Homo sapiens_hsa050200.35221103
139Wnt signaling pathway_Homo sapiens_hsa043100.35176144
140Non-small cell lung cancer_Homo sapiens_hsa052230.31384992
141Carbon metabolism_Homo sapiens_hsa012000.31215744
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28983173
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27363897
144Thyroid hormone synthesis_Homo sapiens_hsa049180.26466738
145Choline metabolism in cancer_Homo sapiens_hsa052310.25801458
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25665678
147Dilated cardiomyopathy_Homo sapiens_hsa054140.24884424
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23265560
149Rap1 signaling pathway_Homo sapiens_hsa040150.21183563

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