NXPH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.39449955
2forebrain neuron differentiation (GO:0021879)7.26883214
3axonal fasciculation (GO:0007413)7.20565157
4cerebellar Purkinje cell differentiation (GO:0021702)6.37342822
5nucleobase catabolic process (GO:0046113)5.70282505
6neuron recognition (GO:0008038)5.67687627
7urogenital system development (GO:0001655)5.15169838
8negative regulation of microtubule polymerization (GO:0031115)5.07978629
9spinal cord association neuron differentiation (GO:0021527)5.07617756
10L-serine metabolic process (GO:0006563)4.99135281
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87019282
12G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.73807494
13neuron cell-cell adhesion (GO:0007158)4.50777183
14cell migration in hindbrain (GO:0021535)4.45705981
15oxidative demethylation (GO:0070989)4.41843443
16layer formation in cerebral cortex (GO:0021819)4.37492242
17neuromuscular process controlling posture (GO:0050884)4.31627642
18positive regulation of gastrulation (GO:2000543)4.29831262
19substrate-independent telencephalic tangential migration (GO:0021826)4.13296711
20substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.13296711
21protein retention in ER lumen (GO:0006621)4.10559800
22neuronal ion channel clustering (GO:0045161)4.09102071
23negative regulation of translation, ncRNA-mediated (GO:0040033)4.06860239
24regulation of translation, ncRNA-mediated (GO:0045974)4.06860239
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.06860239
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.04173604
27regulation of respiratory system process (GO:0044065)4.02166213
28planar cell polarity pathway involved in neural tube closure (GO:0090179)4.01502642
29respiratory system process (GO:0003016)3.96906516
30cerebellar Purkinje cell layer development (GO:0021680)3.96735832
31semaphorin-plexin signaling pathway (GO:0071526)3.84131619
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.80253011
33cell differentiation in hindbrain (GO:0021533)3.79584802
34cranial nerve morphogenesis (GO:0021602)3.77495365
35synaptic vesicle maturation (GO:0016188)3.74405499
36skeletal muscle organ development (GO:0060538)3.71398081
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.65225093
38establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.55036830
39mitochondrion transport along microtubule (GO:0047497)3.55036830
40cochlea morphogenesis (GO:0090103)3.52824263
41hippocampus development (GO:0021766)3.52742421
42gastrulation with mouth forming second (GO:0001702)3.52701802
43synaptic vesicle endocytosis (GO:0048488)3.48126641
44synaptic vesicle exocytosis (GO:0016079)3.47267042
45negative regulation of microtubule polymerization or depolymerization (GO:0031111)3.47189237
46cell communication by electrical coupling (GO:0010644)3.47067037
47neurofilament cytoskeleton organization (GO:0060052)3.45840336
48presynaptic membrane organization (GO:0097090)3.44826810
49negative regulation of catenin import into nucleus (GO:0035414)3.42241355
50regulation of respiratory gaseous exchange (GO:0043576)3.41450810
51establishment of mitochondrion localization (GO:0051654)3.35857390
52diaphragm development (GO:0060539)3.35453136
53sodium ion export (GO:0071436)3.33596786
54cAMP-mediated signaling (GO:0019933)3.32661417
55neuron migration (GO:0001764)3.31401018
56muscle cell fate commitment (GO:0042693)3.31039461
57thalamus development (GO:0021794)3.30646715
58serotonin metabolic process (GO:0042428)3.29161247
59positive regulation of synapse assembly (GO:0051965)3.28962522
60axon ensheathment in central nervous system (GO:0032291)3.28514041
61central nervous system myelination (GO:0022010)3.28514041
62establishment of planar polarity (GO:0001736)3.24976313
63establishment of tissue polarity (GO:0007164)3.24976313
64regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22786240
65dendritic spine morphogenesis (GO:0060997)3.19327691
66regulation of short-term neuronal synaptic plasticity (GO:0048172)3.18902005
67adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.17077988
68histamine secretion (GO:0001821)3.16989544
69cell junction maintenance (GO:0034331)3.16204637
70kidney mesenchyme development (GO:0072074)3.15158550
71dendrite morphogenesis (GO:0048813)3.14252175
72coronary vasculature morphogenesis (GO:0060977)3.13550089
73regulation of synaptic vesicle transport (GO:1902803)3.13392332
74positive regulation of synapse maturation (GO:0090129)3.12588155
75axon extension (GO:0048675)3.11700356
76glutamate secretion (GO:0014047)3.09935212
77regulation of synaptic vesicle exocytosis (GO:2000300)3.05774400
78cytoskeletal anchoring at plasma membrane (GO:0007016)3.04535871
79cell proliferation in forebrain (GO:0021846)3.02270576
80protein localization to synapse (GO:0035418)3.01817121
81barbed-end actin filament capping (GO:0051016)3.00910192
82neurotransmitter secretion (GO:0007269)3.00740107
83response to inactivity (GO:0014854)2.99895437
84regulation of neuronal synaptic plasticity (GO:0048168)2.99626609
85N-glycan processing (GO:0006491)2.99199999
86camera-type eye morphogenesis (GO:0048593)2.98990240
87neuron projection extension involved in neuron projection guidance (GO:1902284)2.96401540
88axon extension involved in axon guidance (GO:0048846)2.96401540
89endothelial cell chemotaxis (GO:0035767)2.96148614
90spinal cord development (GO:0021510)2.94978001
91positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.94525069
92cerebral cortex neuron differentiation (GO:0021895)2.93899311
93metanephric mesenchyme development (GO:0072075)2.92348309
94negative regulation of organelle assembly (GO:1902116)2.91042151
95serine family amino acid biosynthetic process (GO:0009070)2.90798653
96body morphogenesis (GO:0010171)2.90080857
97primary amino compound metabolic process (GO:1901160)2.88586759
98mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.87939615
99negative regulation of microtubule depolymerization (GO:0007026)2.87772975
100positive regulation of axonogenesis (GO:0050772)2.86840478
101regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82469329
102regulation of glycogen (starch) synthase activity (GO:2000465)2.81411939
103telencephalon cell migration (GO:0022029)2.80817273
104regulation of synapse structural plasticity (GO:0051823)2.79963129
105behavioral response to nicotine (GO:0035095)2.78951067
106lymph vessel development (GO:0001945)2.78423982
107peripheral nervous system neuron development (GO:0048935)2.78374034
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77840435
109regulation of axon extension involved in axon guidance (GO:0048841)2.77028462
110regulation of microtubule depolymerization (GO:0031114)2.76638788
111developmental cell growth (GO:0048588)2.76416996
112establishment of nucleus localization (GO:0040023)2.75269450
113cell communication involved in cardiac conduction (GO:0086065)2.74375083
114convergent extension (GO:0060026)2.74026301
115response to auditory stimulus (GO:0010996)2.73251883
116middle ear morphogenesis (GO:0042474)2.71809999
117macroautophagy (GO:0016236)2.71152003
118regulation of axonogenesis (GO:0050770)2.70845614
119protein polyglutamylation (GO:0018095)2.70727616
120locomotory exploration behavior (GO:0035641)2.70287256
121cellular response to prostaglandin stimulus (GO:0071379)2.69820785
122Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.69759706
123biotin metabolic process (GO:0006768)2.68200512
124nucleosome disassembly (GO:0006337)2.66837908
125protein-DNA complex disassembly (GO:0032986)2.66837908
126negative regulation of axon extension (GO:0030517)2.65286478
127negative regulation of axon guidance (GO:1902668)2.65148302
128histamine transport (GO:0051608)2.64284871
129neuron projection extension (GO:1990138)2.63897757
130outflow tract septum morphogenesis (GO:0003148)2.63221145
131positive regulation of filopodium assembly (GO:0051491)2.62904136
132forebrain cell migration (GO:0021885)2.62838148
1334-hydroxyproline metabolic process (GO:0019471)2.62650366
134regulation of dopamine metabolic process (GO:0042053)2.62572244
135regulation of catecholamine metabolic process (GO:0042069)2.62572244
136regulation of translational fidelity (GO:0006450)2.60603420
137regulation of chromatin binding (GO:0035561)2.60100742
138viral transcription (GO:0019083)2.59196050
139CDP-diacylglycerol metabolic process (GO:0046341)2.57153000
140response to parathyroid hormone (GO:0071107)2.55464878
141ribosomal small subunit biogenesis (GO:0042274)2.55360682
142tooth mineralization (GO:0034505)2.54319243
143regulation of establishment of planar polarity (GO:0090175)2.53405673
144peptidyl-arginine omega-N-methylation (GO:0035247)2.51525305
145amyloid precursor protein catabolic process (GO:0042987)2.49759606
146proline biosynthetic process (GO:0006561)2.47296410
147negative regulation of cell size (GO:0045792)2.46564378
148embryonic body morphogenesis (GO:0010172)2.45622900
149neuron fate specification (GO:0048665)2.45128559
150regulation of fatty acid beta-oxidation (GO:0031998)2.44118527
151regulation of axon guidance (GO:1902667)2.42981009
152glucose 6-phosphate metabolic process (GO:0051156)2.41610966
153regulation of cardioblast differentiation (GO:0051890)2.40968066
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40204324
155stress granule assembly (GO:0034063)2.36303518
156protein heterotrimerization (GO:0070208)2.35157980
157translational termination (GO:0006415)2.35117786
158regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.34900821
159positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.34900821
160cell-cell junction maintenance (GO:0045217)2.34804001
161RNA localization (GO:0006403)2.32860860
162positive regulation of CREB transcription factor activity (GO:0032793)2.32763737
163peptidyl-proline hydroxylation (GO:0019511)2.31683785
164positive regulation of dendritic spine morphogenesis (GO:0061003)2.31029453
165negative regulation of axon extension involved in axon guidance (GO:0048843)2.31000140
166thyroid gland development (GO:0030878)2.30808707
167regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.30563172
168synaptic vesicle docking involved in exocytosis (GO:0016081)2.29839264
169dopamine receptor signaling pathway (GO:0007212)2.28992301
170non-canonical Wnt signaling pathway (GO:0035567)2.28360232
171CDP-diacylglycerol biosynthetic process (GO:0016024)2.27822738
172outer ear morphogenesis (GO:0042473)2.26793419
173eye morphogenesis (GO:0048592)2.23514658
174intracellular estrogen receptor signaling pathway (GO:0030520)2.22323318
175proximal/distal pattern formation (GO:0009954)2.22285587
176peptidyl-arginine N-methylation (GO:0035246)2.21272439
177peptidyl-arginine methylation (GO:0018216)2.21272439
178pharyngeal system development (GO:0060037)2.20178578
179cellular response to catecholamine stimulus (GO:0071870)2.19440096
180cellular response to monoamine stimulus (GO:0071868)2.19440096
181response to pheromone (GO:0019236)13.3145646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.71385522
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.62507624
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14998789
4* EZH2_27304074_Chip-Seq_ESCs_Mouse3.07411861
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02087197
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.92535993
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89179518
8* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.86053766
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75209994
10* EZH2_27294783_Chip-Seq_ESCs_Mouse2.69986960
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69923156
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69923156
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68568631
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.64314996
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61492497
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.60118229
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.58366342
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52715997
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50906109
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.50710349
21REST_21632747_ChIP-Seq_MESCs_Mouse2.42638506
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41308908
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39681467
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.29912553
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.29098160
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28943272
27* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25970633
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19155912
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15706915
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14416474
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.12754112
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10285298
33RACK7_27058665_Chip-Seq_MCF-7_Human2.03596877
34CBX2_27304074_Chip-Seq_ESCs_Mouse2.01710027
35RNF2_27304074_Chip-Seq_NSC_Mouse1.99941173
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92787999
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92716714
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.91441459
39* TET1_21451524_ChIP-Seq_MESCs_Mouse1.89417568
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.87027747
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85364921
42IGF1R_20145208_ChIP-Seq_DFB_Human1.84352635
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83648876
44MYC_22102868_ChIP-Seq_BL_Human1.80298057
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79283177
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76277510
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.69766305
48AR_21572438_ChIP-Seq_LNCaP_Human1.68805093
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66811812
50XRN2_22483619_ChIP-Seq_HELA_Human1.64271328
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60494985
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.59393118
53* KDM2B_26808549_Chip-Seq_K562_Human1.59283573
54DROSHA_22980978_ChIP-Seq_HELA_Human1.58910788
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.58760462
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58569506
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.58055968
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56058079
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54086263
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53123217
61* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52613775
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50325126
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49768678
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.46941185
65* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46365715
66VDR_21846776_ChIP-Seq_THP-1_Human1.45091896
67* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44961669
68* P68_20966046_ChIP-Seq_HELA_Human1.44234400
69ZNF274_21170338_ChIP-Seq_K562_Hela1.41283434
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37844547
71GBX2_23144817_ChIP-Seq_PC3_Human1.35861781
72* SA1_27219007_Chip-Seq_ERYTHROID_Human1.35210365
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34492347
74* KDM2B_26808549_Chip-Seq_JURKAT_Human1.31323147
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31242252
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30926103
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29475635
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27697523
79TP53_22127205_ChIP-Seq_IMR90_Human1.24601056
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23639283
81* LXR_22292898_ChIP-Seq_THP-1_Human1.23521079
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.23285560
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23109682
84* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22656294
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22275931
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22141013
87SMC4_20622854_ChIP-Seq_HELA_Human1.21874732
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.21532300
89CTCF_27219007_Chip-Seq_Bcells_Human1.21273747
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21153148
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20141787
92MYC_18555785_ChIP-Seq_MESCs_Mouse1.19355693
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18068883
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17806037
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16549071
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16228462
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16076552
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16012017
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15073555
100* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14932969
101STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14860406
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.14092182
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12821708
104ZNF263_19887448_ChIP-Seq_K562_Human1.12096267
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10632507
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07925412
107FOXP1_21924763_ChIP-Seq_HESCs_Human1.07825437
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07343579
109TAF15_26573619_Chip-Seq_HEK293_Human1.06529810
110ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05912682
111GATA1_26923725_Chip-Seq_HPCs_Mouse1.05763769
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05570846
113SMAD3_21741376_ChIP-Seq_ESCs_Human1.02503413
114AR_19668381_ChIP-Seq_PC3_Human1.02317690
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02261859
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01868362
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01413136
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99825882
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99729792
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99465828
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99051535
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98700915
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98366852
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98092773
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97185395
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95828864
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94576280
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93508927
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92867901
130* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91787330
131ISL1_27105846_Chip-Seq_CPCs_Mouse0.90127953
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.88037052
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85969173
134CREB1_26743006_Chip-Seq_LNCaP_Human0.84896660
135TP63_19390658_ChIP-ChIP_HaCaT_Human0.84517861
136POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.83261430
137P300_19829295_ChIP-Seq_ESCs_Human0.80683987
138TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80092279
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79928293
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79777982
141KDM2B_26808549_Chip-Seq_DND41_Human0.78788106
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.77929738
143* SMAD4_21741376_ChIP-Seq_HESCs_Human0.74594491
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74149709
145* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73922883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting7.78682412
2MP0008995_early_reproductive_senescence5.29374089
3MP0005645_abnormal_hypothalamus_physiol4.91461266
4MP0006276_abnormal_autonomic_nervous4.58918233
5MP0005423_abnormal_somatic_nervous3.91483308
6MP0003121_genomic_imprinting3.89726757
7MP0000778_abnormal_nervous_system3.16871233
8MP0004859_abnormal_synaptic_plasticity3.10926726
9MP0002249_abnormal_larynx_morphology2.82249905
10MP0003705_abnormal_hypodermis_morpholog2.78910750
11MP0008961_abnormal_basal_metabolism2.73369471
12MP0002653_abnormal_ependyma_morphology2.66831590
13MP0003890_abnormal_embryonic-extraembry2.63002144
14MP0001529_abnormal_vocalization2.35910861
15MP0000678_abnormal_parathyroid_gland2.24087024
16MP0010030_abnormal_orbit_morphology2.23529460
17MP0000566_synostosis2.21044910
18MP0001984_abnormal_olfaction2.17875580
19MP0002822_catalepsy2.17455864
20MP0003635_abnormal_synaptic_transmissio2.10059760
21MP0002063_abnormal_learning/memory/cond2.00215839
22MP0004270_analgesia1.99607519
23MP0000049_abnormal_middle_ear1.99334431
24MP0000537_abnormal_urethra_morphology1.98406528
25MP0001346_abnormal_lacrimal_gland1.97254103
26MP0009053_abnormal_anal_canal1.91002523
27MP0005257_abnormal_intraocular_pressure1.86273985
28MP0001348_abnormal_lacrimal_gland1.85494699
29MP0001440_abnormal_grooming_behavior1.83723645
30MP0002733_abnormal_thermal_nociception1.82913276
31MP0001502_abnormal_circadian_rhythm1.82006851
32MP0008438_abnormal_cutaneous_collagen1.77721746
33MP0001188_hyperpigmentation1.74482265
34MP0002557_abnormal_social/conspecific_i1.70533776
35MP0004133_heterotaxia1.70183327
36MP0003880_abnormal_central_pattern1.62572060
37MP0002184_abnormal_innervation1.61712217
38MP0000538_abnormal_urinary_bladder1.55605662
39MP0010234_abnormal_vibrissa_follicle1.55268711
40MP0003123_paternal_imprinting1.55251526
41MP0002796_impaired_skin_barrier1.54917769
42MP0004811_abnormal_neuron_physiology1.52633500
43MP0005501_abnormal_skin_physiology1.52264611
44MP0002909_abnormal_adrenal_gland1.50697291
45MP0002572_abnormal_emotion/affect_behav1.49316629
46MP0002638_abnormal_pupillary_reflex1.49258254
47MP0000579_abnormal_nail_morphology1.47003286
48MP0003879_abnormal_hair_cell1.46577079
49MP0002064_seizures1.45995836
50MP0005409_darkened_coat_color1.44370279
51MP0001501_abnormal_sleep_pattern1.41894565
52MP0004185_abnormal_adipocyte_glucose1.41370172
53MP0000762_abnormal_tongue_morphology1.41149104
54MP0005503_abnormal_tendon_morphology1.41031374
55MP0003878_abnormal_ear_physiology1.38444335
56MP0005377_hearing/vestibular/ear_phenot1.38444335
57MP0003942_abnormal_urinary_system1.38045694
58MP0002877_abnormal_melanocyte_morpholog1.37786735
59MP0000955_abnormal_spinal_cord1.36504143
60MP0005394_taste/olfaction_phenotype1.36023121
61MP0005499_abnormal_olfactory_system1.36023121
62MP0000751_myopathy1.34286799
63MP0009379_abnormal_foot_pigmentation1.33500183
64MP0000631_abnormal_neuroendocrine_gland1.33310722
65MP0009745_abnormal_behavioral_response1.32669815
66MP0005646_abnormal_pituitary_gland1.32532960
67MP0000003_abnormal_adipose_tissue1.28651034
68MP0003755_abnormal_palate_morphology1.27154120
69MP0000733_abnormal_muscle_development1.26691468
70MP0002932_abnormal_joint_morphology1.26321676
71MP0002116_abnormal_craniofacial_bone1.25754040
72MP0003183_abnormal_peptide_metabolism1.25158651
73MP0000534_abnormal_ureter_morphology1.23945288
74MP0002882_abnormal_neuron_morphology1.23021035
75MP0001849_ear_inflammation1.20510839
76MP0000569_abnormal_digit_pigmentation1.19432887
77MP0009250_abnormal_appendicular_skeleto1.17886747
78MP0002152_abnormal_brain_morphology1.17414772
79MP0008789_abnormal_olfactory_epithelium1.15196304
80MP0009780_abnormal_chondrocyte_physiolo1.14311044
81MP0001970_abnormal_pain_threshold1.13859653
82MP0002272_abnormal_nervous_system1.13422174
83MP0003787_abnormal_imprinting1.13330655
84MP0009046_muscle_twitch1.13266890
85MP0005670_abnormal_white_adipose1.13069576
86MP0005666_abnormal_adipose_tissue1.11086539
87MP0003115_abnormal_respiratory_system1.10896338
88MP0003786_premature_aging1.10529164
89MP0001727_abnormal_embryo_implantation1.10361389
90MP0003315_abnormal_perineum_morphology1.08723038
91MP0005375_adipose_tissue_phenotype1.05537370
92MP0001486_abnormal_startle_reflex1.04999442
93MP0005623_abnormal_meninges_morphology1.03927316
94MP0003861_abnormal_nervous_system1.02913634
95MP0003119_abnormal_digestive_system1.01383573
96MP0002697_abnormal_eye_size1.01133602
97MP0002234_abnormal_pharynx_morphology1.00950155
98MP0002734_abnormal_mechanical_nocicepti1.00728866
99MP0003935_abnormal_craniofacial_develop1.00229679
100MP0008057_abnormal_DNA_replication0.97587447
101MP0002066_abnormal_motor_capabilities/c0.97062777
102MP0003172_abnormal_lysosome_physiology0.94990505
103MP0005187_abnormal_penis_morphology0.94958027
104MP0010386_abnormal_urinary_bladder0.94283224
105MP0003959_abnormal_lean_body0.91813902
106MP0003329_amyloid_beta_deposits0.91324241
107MP0000026_abnormal_inner_ear0.91155720
108MP0000681_abnormal_thyroid_gland0.90930870
109MP0005535_abnormal_body_temperature0.90643468
110MP0003938_abnormal_ear_development0.90521379
111MP0009384_cardiac_valve_regurgitation0.90458902
112MP0002751_abnormal_autonomic_nervous0.89937015
113MP0002177_abnormal_outer_ear0.88940923
114MP0001968_abnormal_touch/_nociception0.88673107
115MP0003937_abnormal_limbs/digits/tail_de0.87290877
116MP0002067_abnormal_sensory_capabilities0.85881349
117MP0002160_abnormal_reproductive_system0.85611560
118MP0002735_abnormal_chemical_nociception0.85450795
119MP0002092_abnormal_eye_morphology0.84144844
120MP0002098_abnormal_vibrissa_morphology0.83672708
121MP0002233_abnormal_nose_morphology0.83368170
122MP0002114_abnormal_axial_skeleton0.82669734
123MP0000467_abnormal_esophagus_morphology0.82659242
124MP0004142_abnormal_muscle_tone0.82312309
125MP0002069_abnormal_eating/drinking_beha0.81965015
126MP0005508_abnormal_skeleton_morphology0.81956943
127MP0005248_abnormal_Harderian_gland0.81890364
128MP0008569_lethality_at_weaning0.79718140
129MP0003948_abnormal_gas_homeostasis0.79657852
130MP0002752_abnormal_somatic_nervous0.79260828
131MP0004130_abnormal_muscle_cell0.78764982
132MP0002081_perinatal_lethality0.76840843
133MP0000462_abnormal_digestive_system0.76585306
134MP0000377_abnormal_hair_follicle0.76551509
135MP0008932_abnormal_embryonic_tissue0.76454036
136MP0001299_abnormal_eye_distance/0.75421777
137MP0004885_abnormal_endolymph0.75252185
138MP0002089_abnormal_postnatal_growth/wei0.74788867
139MP0002111_abnormal_tail_morphology0.73928353
140MP0002282_abnormal_trachea_morphology0.73867613
141MP0005076_abnormal_cell_differentiation0.73338092
142MP0005386_behavior/neurological_phenoty0.72939347
143MP0004924_abnormal_behavior0.72939347
144MP0004272_abnormal_basement_membrane0.72081813
145MP0004134_abnormal_chest_morphology0.72022913
146MP0004233_abnormal_muscle_weight0.70792365
147MP0003385_abnormal_body_wall0.69937527
148MP0003632_abnormal_nervous_system0.69702838
149MP0003953_abnormal_hormone_level0.68127012
150MP0001943_abnormal_respiration0.67743571
151MP0005448_abnormal_energy_balance0.65142854
152MP0005275_abnormal_skin_tensile0.63267263
153MP0004858_abnormal_nervous_system0.60937532
154MP0004085_abnormal_heartbeat0.60006421
155MP0008770_decreased_survivor_rate0.59843573
156MP0002082_postnatal_lethality0.59336405
157MP0010770_preweaning_lethality0.59336405
158MP0003137_abnormal_impulse_conducting0.58570443
159MP0010769_abnormal_survival0.58316319
160MP0010768_mortality/aging0.57886183
161MP0005197_abnormal_uvea_morphology0.51677772
162MP0000013_abnormal_adipose_tissue0.50897270
163MP0005253_abnormal_eye_physiology0.48385957

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)9.75044072
2Polyphagia (HP:0002591)8.82140048
3Abnormal eating behavior (HP:0100738)6.92407165
4Sleep apnea (HP:0010535)6.24641280
5Abnormality of the labia minora (HP:0012880)4.92457034
6Esotropia (HP:0000565)4.55444363
7Deep palmar crease (HP:0006191)4.03833061
8Abnormal hair whorl (HP:0010721)3.99071154
9Oligomenorrhea (HP:0000876)3.91210323
10Abnormality of the aortic arch (HP:0012303)3.91076697
11Hypoventilation (HP:0002791)3.66717419
12Exotropia (HP:0000577)3.58332815
13Narrow nasal bridge (HP:0000446)3.51910255
14Supranuclear gaze palsy (HP:0000605)3.48442919
15Premature rupture of membranes (HP:0001788)3.48052727
16Focal seizures (HP:0007359)3.34090322
17Poor suck (HP:0002033)3.31400690
18Agitation (HP:0000713)3.30835177
19Myokymia (HP:0002411)3.27028305
20Focal motor seizures (HP:0011153)3.26775200
21Long palpebral fissure (HP:0000637)3.10065361
22Calcaneovalgus deformity (HP:0001848)3.08095667
23Turricephaly (HP:0000262)3.05651404
24Bladder diverticulum (HP:0000015)3.03093006
25Labial hypoplasia (HP:0000066)3.00548657
26Abnormality of the lower motor neuron (HP:0002366)3.00515664
27High anterior hairline (HP:0009890)2.96791258
28Genu recurvatum (HP:0002816)2.94889559
29Thyroid-stimulating hormone excess (HP:0002925)2.94796421
30Congenital malformation of the right heart (HP:0011723)2.93275753
31Double outlet right ventricle (HP:0001719)2.93275753
32Open mouth (HP:0000194)2.92703658
33Ankle clonus (HP:0011448)2.88832322
34Renal duplication (HP:0000075)2.82919197
35Visual hallucinations (HP:0002367)2.81545735
36Cerebral inclusion bodies (HP:0100314)2.79645448
37Renovascular hypertension (HP:0100817)2.79286461
38Protrusio acetabuli (HP:0003179)2.78333891
39Overriding aorta (HP:0002623)2.76634941
40Deformed tarsal bones (HP:0008119)2.64900148
41Hypoplastic female external genitalia (HP:0012815)2.62920555
42Protruding tongue (HP:0010808)2.61020601
43Macroorchidism (HP:0000053)2.59697032
44Limb dystonia (HP:0002451)2.58765439
45Patellar dislocation (HP:0002999)2.58478891
46Shallow orbits (HP:0000586)2.58474460
47Broad distal phalanx of finger (HP:0009836)2.48987580
48Lissencephaly (HP:0001339)2.47504195
49Periauricular skin pits (HP:0100277)2.41850780
50Preauricular pit (HP:0004467)2.41850780
51Generalized hypotonia (HP:0001290)2.41763315
52Amblyopia (HP:0000646)2.39425451
53Specific learning disability (HP:0001328)2.38504225
54Abnormality of dentin (HP:0010299)2.37888735
55Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37101729
56Hip dysplasia (HP:0001385)2.36577684
57Growth hormone deficiency (HP:0000824)2.36227645
58Impaired vibration sensation in the lower limbs (HP:0002166)2.36035118
59Ankle contracture (HP:0006466)2.31025251
60Truncus arteriosus (HP:0001660)2.29500734
61Fragile skin (HP:0001030)2.29361243
62Abnormality of the corticospinal tract (HP:0002492)2.26812889
63Hypercalcemia (HP:0003072)2.26812467
64Small hand (HP:0200055)2.24768888
65Abnormal ventriculo-arterial connection (HP:0011563)2.24218442
66Transposition of the great arteries (HP:0001669)2.24218442
67Abnormal connection of the cardiac segments (HP:0011545)2.24218442
68Hyperthyroidism (HP:0000836)2.23735940
69Poor eye contact (HP:0000817)2.23433718
70Coronal craniosynostosis (HP:0004440)2.22959136
71Urinary urgency (HP:0000012)2.22854076
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22360205
73Abnormality of the phalanges of the hallux (HP:0010057)2.21730490
74Lip pit (HP:0100267)2.21128670
75Depression (HP:0000716)2.19420900
76Bowel diverticulosis (HP:0005222)2.19192368
77Neonatal respiratory distress (HP:0002643)2.18748080
78Posterior embryotoxon (HP:0000627)2.18191390
79Hallux valgus (HP:0001822)2.17589513
80Hyperextensible skin (HP:0000974)2.17269585
81Mutism (HP:0002300)2.16546091
82Severe muscular hypotonia (HP:0006829)2.16533353
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16482548
84Hypoplasia of the brainstem (HP:0002365)2.16482548
85Biconcave vertebral bodies (HP:0004586)2.16263521
86Hemiparesis (HP:0001269)2.15858831
87Progressive cerebellar ataxia (HP:0002073)2.15516760
88Deviation of the hallux (HP:0010051)2.15467134
89Shawl scrotum (HP:0000049)2.15452035
90Facial cleft (HP:0002006)2.14029729
91Hyperparathyroidism (HP:0000843)2.11499133
92Abnormality of pain sensation (HP:0010832)2.09435896
93Impaired pain sensation (HP:0007328)2.09435896
94Infantile muscular hypotonia (HP:0008947)2.09268003
95Narrow forehead (HP:0000341)2.07880528
96Flat cornea (HP:0007720)2.07850566
97Unilateral renal agenesis (HP:0000122)2.07189710
98Epileptic encephalopathy (HP:0200134)2.06331772
99Hypercortisolism (HP:0001578)2.05419805
100Spastic gait (HP:0002064)2.05010194
101Morphological abnormality of the middle ear (HP:0008609)2.04258931
102Wrist flexion contracture (HP:0001239)2.04169943
103Megalocornea (HP:0000485)2.03077997
104Abnormality of the calcaneus (HP:0008364)2.02092650
105Papilledema (HP:0001085)2.01537445
106Attention deficit hyperactivity disorder (HP:0007018)2.00962601
107Torticollis (HP:0000473)2.00633847
108Atelectasis (HP:0100750)2.00074542
109Increased nuchal translucency (HP:0010880)1.99759801
110Hyperacusis (HP:0010780)1.98161986
111Cortical dysplasia (HP:0002539)1.96931163
112Abnormality of the line of Schwalbe (HP:0008048)1.96617114
113Hypogonadotrophic hypogonadism (HP:0000044)1.96112850
114Neonatal short-limb short stature (HP:0008921)1.95543019
115Obstructive sleep apnea (HP:0002870)1.95078000
116Absence seizures (HP:0002121)1.93971949
117Truncal ataxia (HP:0002078)1.93886680
118Right ventricular cardiomyopathy (HP:0011663)1.93842981
119Abnormal gallbladder physiology (HP:0012438)1.93708818
120Cholecystitis (HP:0001082)1.93708818
121Generalized tonic-clonic seizures (HP:0002069)1.93394238
122Impaired social interactions (HP:0000735)1.93363358
123Abnormal social behavior (HP:0012433)1.93363358
124Precocious puberty (HP:0000826)1.92411712
125Excessive salivation (HP:0003781)1.91484103
126Drooling (HP:0002307)1.91484103
127Vertebral compression fractures (HP:0002953)1.90288809
128Skin pits (HP:0100276)1.89842454
129Restlessness (HP:0000711)1.89331176
130Neoplasm of the heart (HP:0100544)1.88420196
131Shoulder girdle muscle weakness (HP:0003547)1.87008586
132Ulnar bowing (HP:0003031)1.86485798
133Atrophic scars (HP:0001075)1.86140279
134Abnormality of glycosphingolipid metabolism (HP:0004343)1.85209182
135Abnormality of glycolipid metabolism (HP:0010969)1.85209182
136Abnormality of liposaccharide metabolism (HP:0010968)1.85209182
137Septate vagina (HP:0001153)1.84795522
138Adducted thumb (HP:0001181)1.84722539
139Chorioretinal atrophy (HP:0000533)1.82803083
140Morphological abnormality of the pyramidal tract (HP:0002062)1.82596372
141Abnormality of the labia (HP:0000058)1.82300889
142Congenital glaucoma (HP:0001087)1.81946254
143Growth hormone excess (HP:0000845)1.80982394
144Astrocytoma (HP:0009592)1.80942513
145Abnormality of the astrocytes (HP:0100707)1.80942513
146Elbow flexion contracture (HP:0002987)1.80511011
147Autism (HP:0000717)1.79261944
148Craniofacial dystonia (HP:0012179)1.78931125
149Insomnia (HP:0100785)1.78311287
150Psychosis (HP:0000709)1.77971608
151Mitral regurgitation (HP:0001653)1.77952721
152Pointed chin (HP:0000307)1.76525625
153Soft skin (HP:0000977)1.75852569
154Iris hypopigmentation (HP:0007730)1.75647581
155Anteriorly placed anus (HP:0001545)1.74939047
156Decreased muscle mass (HP:0003199)1.74935430
157Thin bony cortex (HP:0002753)1.74837437
158Anxiety (HP:0000739)1.74202422
159Dialeptic seizures (HP:0011146)1.72426830
160Enlarged penis (HP:0000040)1.72171776
161Menstrual irregularities (HP:0000858)1.72132191
162Cholelithiasis (HP:0001081)1.70177208
163Lower limb muscle weakness (HP:0007340)1.69915922
164Abnormality of calcium-phosphate metabolism (HP:0100530)1.69748045
165Elfin facies (HP:0004428)1.69655870
166Anterior segment dysgenesis (HP:0007700)1.68933191
167Sparse lateral eyebrow (HP:0005338)1.68111146
168Sudden death (HP:0001699)1.67521479
169Focal dystonia (HP:0004373)1.66732692
170Facial hemangioma (HP:0000329)1.65315270
171Aqueductal stenosis (HP:0002410)1.64794651
172Large eyes (HP:0001090)1.64398540
173Blue sclerae (HP:0000592)1.64140725
174Pterygium (HP:0001059)1.62480440
175Neurofibrillary tangles (HP:0002185)1.62140543
176Polycystic kidney dysplasia (HP:0000113)1.62130159
177Mitral valve prolapse (HP:0001634)1.61193414
178Knee flexion contracture (HP:0006380)1.60031566
179Megalencephaly (HP:0001355)1.59161869
180Abnormality of the gallbladder (HP:0005264)1.58746961
181Sacral dimple (HP:0000960)1.57638206
182Venous insufficiency (HP:0005293)1.57327369
183Cubitus valgus (HP:0002967)1.56910367
184Germ cell neoplasia (HP:0100728)1.56400554
185Abnormality of the diencephalon (HP:0010662)1.53838385
186Aplasia involving bones of the upper limbs (HP:0009823)1.53506331
187Aplasia of the phalanges of the hand (HP:0009802)1.53506331
188Aplasia involving bones of the extremities (HP:0009825)1.53506331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K97.26917957
2FGFR23.77025793
3SIK33.70601870
4SMG13.47920833
5IRAK23.15575455
6MAP3K123.11128373
7UHMK12.93541108
8TYRO32.90710354
9MARK12.85233842
10PRKD32.79576802
11NTRK22.71907820
12EEF2K2.64133810
13BCR2.63917635
14FGFR42.54948590
15PAK62.41143821
16PRPF4B2.39015417
17EPHA32.23717023
18CDK122.23715031
19PKN22.23353070
20IRAK12.20838005
21EPHB22.16221761
22PDGFRA1.97344654
23KSR11.90074813
24CDK191.75595316
25MAP3K41.63613815
26WNK31.62199238
27VRK21.59846298
28MINK11.57678797
29MAP2K41.56137570
30NTRK31.52445888
31NME21.52192833
32ARAF1.50618125
33BRAF1.50504236
34MOS1.48468341
35MAP3K101.40534746
36TAOK21.38235025
37ACVR1B1.35156592
38IRAK31.21987120
39MTOR1.21740851
40MAP2K71.21565418
41ICK1.18771922
42PAK31.18047669
43TAF11.17726517
44IRAK41.17589243
45CDK81.15801864
46CDK71.09317108
47ERN11.05652070
48FER1.03929172
49CAMKK11.03654802
50CDK181.03316417
51DYRK21.02800503
52ILK1.02749790
53ERBB21.02283213
54CASK1.01269141
55AKT30.99115579
56PTK20.95639799
57EPHA20.95554437
58BRSK10.95221497
59MAPK130.93666537
60FGFR30.92752278
61CHEK20.90777906
62RIPK10.89829716
63LRRK20.87589353
64AURKA0.84970318
65CDK150.84310057
66RET0.84109616
67SIK20.83744979
68LIMK10.81754273
69CSNK1G30.81176587
70NEK10.80036280
71MAP3K110.77763414
72CDK140.77421476
73HIPK20.77133287
74CDK11A0.75859126
75PRKCI0.75519710
76CSNK1G20.73613423
77ABL20.73114258
78ITK0.72881918
79CDK50.72252372
80WNK40.69237609
81FGFR10.68752976
82PHKG10.68703823
83PHKG20.68703823
84BCKDK0.67751887
85CDK90.67152024
86BRD40.66632696
87DDR20.65876481
88MAP2K20.61544796
89RPS6KC10.61094037
90RPS6KL10.61094037
91PIM20.61009307
92SGK4940.56587621
93SGK2230.56587621
94CAMK1G0.55924782
95MAPK90.55591053
96WNK10.54160018
97LATS20.53690899
98DYRK1B0.53450624
99PRKAA10.52859983
100MAPK110.52624417
101PRKCH0.51663142
102NEK20.50231528
103MAP3K80.49429472
104TESK20.47551594
105TRIB30.46980692
106CAMK1D0.46655504
107STK380.45383484
108BMPR1B0.44937051
109RPS6KA60.44199091
110MAP3K60.43245277
111PDPK10.42708198
112RPS6KB20.42701079
113MET0.42656851
114STK40.42504149
115CHEK10.42428804
116ERBB30.41707506
117PAK20.41456588
118STK160.41181415
119CSNK1G10.40933097
120TESK10.39947361
121SGK30.39319459
122PRKCZ0.38670549
123DAPK30.37854040
124VRK10.37454629
125AKT10.36777358
126OXSR10.36201750
127PDGFRB0.35476657
128INSRR0.35223321
129ROCK20.34604344
130RPS6KA20.32786654
131AKT20.32055627
132MAP3K50.29447182
133MAPK40.27847930
134CAMK2A0.27761261
135TGFBR10.27711063
136CSNK1A1L0.25697823
137PRKACG0.25582751
138DYRK1A0.25447796
139TBK10.24652250
140MATK0.24587291
141SIK10.23182292
142FYN0.22595645
143ROCK10.22559243
144ADRBK10.21531127
145CDC42BPA0.21409918
146MAPK100.21101426
147PRKCG0.21034010
148CAMK10.20772013
149KSR20.18933831
150CAMK40.18672526
151CCNB10.17981305
152NTRK10.17278936
153CAMKK20.15759696
154DYRK30.14885361
155CSNK1E0.13852029
156MARK20.13023350

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.39548530
2Axon guidance_Homo sapiens_hsa043603.22051522
3Synaptic vesicle cycle_Homo sapiens_hsa047212.94266347
4Cocaine addiction_Homo sapiens_hsa050302.47665557
5Nicotine addiction_Homo sapiens_hsa050332.45792333
6Insulin secretion_Homo sapiens_hsa049112.20668564
7GABAergic synapse_Homo sapiens_hsa047272.13757291
8Dopaminergic synapse_Homo sapiens_hsa047282.10809001
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09378077
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98866232
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91245883
12Biosynthesis of amino acids_Homo sapiens_hsa012301.91036630
13Notch signaling pathway_Homo sapiens_hsa043301.85613267
14Circadian entrainment_Homo sapiens_hsa047131.84187272
15Gap junction_Homo sapiens_hsa045401.75169688
16Morphine addiction_Homo sapiens_hsa050321.70334026
17Serotonergic synapse_Homo sapiens_hsa047261.68014311
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65043186
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61431210
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.61340943
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60115478
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55320679
23Ribosome_Homo sapiens_hsa030101.50515264
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48979885
25Vibrio cholerae infection_Homo sapiens_hsa051101.47587087
26Amphetamine addiction_Homo sapiens_hsa050311.46531916
27ErbB signaling pathway_Homo sapiens_hsa040121.45376246
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45188083
29Basal cell carcinoma_Homo sapiens_hsa052171.43892945
30Glutamatergic synapse_Homo sapiens_hsa047241.42342929
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42176445
32Vitamin B6 metabolism_Homo sapiens_hsa007501.41351982
33Bladder cancer_Homo sapiens_hsa052191.39924250
34AMPK signaling pathway_Homo sapiens_hsa041521.39106018
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36728345
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31808218
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.29471057
38Cardiac muscle contraction_Homo sapiens_hsa042601.27293790
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26672016
40Cholinergic synapse_Homo sapiens_hsa047251.25121370
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23612900
42Carbon metabolism_Homo sapiens_hsa012001.23449927
43Pentose phosphate pathway_Homo sapiens_hsa000301.21870698
44GnRH signaling pathway_Homo sapiens_hsa049121.21640733
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20951684
46Hippo signaling pathway_Homo sapiens_hsa043901.18313666
47Wnt signaling pathway_Homo sapiens_hsa043101.16738321
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.15259872
49Renin secretion_Homo sapiens_hsa049241.14257925
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12669377
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08201121
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06124330
53Lysine degradation_Homo sapiens_hsa003101.05767430
54Salivary secretion_Homo sapiens_hsa049701.05111189
55Butanoate metabolism_Homo sapiens_hsa006501.04976573
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01236233
57MAPK signaling pathway_Homo sapiens_hsa040101.00312855
58Dilated cardiomyopathy_Homo sapiens_hsa054140.98995292
59Oxytocin signaling pathway_Homo sapiens_hsa049210.97716251
60Melanogenesis_Homo sapiens_hsa049160.96280465
61Pancreatic cancer_Homo sapiens_hsa052120.95615141
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.95599989
63Melanoma_Homo sapiens_hsa052180.93855996
64Alcoholism_Homo sapiens_hsa050340.92784744
65Type II diabetes mellitus_Homo sapiens_hsa049300.92500798
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92351195
67Circadian rhythm_Homo sapiens_hsa047100.92089236
68Oocyte meiosis_Homo sapiens_hsa041140.91743054
69Fructose and mannose metabolism_Homo sapiens_hsa000510.90503524
70Thyroid cancer_Homo sapiens_hsa052160.89892956
71Olfactory transduction_Homo sapiens_hsa047400.89608445
72Inositol phosphate metabolism_Homo sapiens_hsa005620.89449890
73Estrogen signaling pathway_Homo sapiens_hsa049150.89407219
74Gastric acid secretion_Homo sapiens_hsa049710.88602454
75N-Glycan biosynthesis_Homo sapiens_hsa005100.88339702
76Colorectal cancer_Homo sapiens_hsa052100.86777183
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86074280
78Glioma_Homo sapiens_hsa052140.84045185
79Taste transduction_Homo sapiens_hsa047420.83937782
80Choline metabolism in cancer_Homo sapiens_hsa052310.83545092
81Ras signaling pathway_Homo sapiens_hsa040140.81593112
82Renin-angiotensin system_Homo sapiens_hsa046140.81462821
83Prion diseases_Homo sapiens_hsa050200.81385307
84Fatty acid biosynthesis_Homo sapiens_hsa000610.81319545
85Endometrial cancer_Homo sapiens_hsa052130.80119068
86Arginine and proline metabolism_Homo sapiens_hsa003300.79763300
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79403068
88One carbon pool by folate_Homo sapiens_hsa006700.78101108
89Galactose metabolism_Homo sapiens_hsa000520.77683839
90Arginine biosynthesis_Homo sapiens_hsa002200.77206385
91Long-term depression_Homo sapiens_hsa047300.75632828
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75160110
93Bile secretion_Homo sapiens_hsa049760.74741223
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74542426
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73131468
96Pyruvate metabolism_Homo sapiens_hsa006200.73077969
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72750511
98Phenylalanine metabolism_Homo sapiens_hsa003600.72724465
99Hedgehog signaling pathway_Homo sapiens_hsa043400.72379260
100Cell cycle_Homo sapiens_hsa041100.72204058
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71217061
102VEGF signaling pathway_Homo sapiens_hsa043700.71084822
103Prostate cancer_Homo sapiens_hsa052150.70620912
104Steroid biosynthesis_Homo sapiens_hsa001000.70532265
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70358685
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69932075
107MicroRNAs in cancer_Homo sapiens_hsa052060.69237661
108Renal cell carcinoma_Homo sapiens_hsa052110.68119146
109Small cell lung cancer_Homo sapiens_hsa052220.67810524
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67792892
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.67473456
112HIF-1 signaling pathway_Homo sapiens_hsa040660.67261583
113Collecting duct acid secretion_Homo sapiens_hsa049660.65215901
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65112809
115Long-term potentiation_Homo sapiens_hsa047200.64370384
116Ovarian steroidogenesis_Homo sapiens_hsa049130.64072056
117mRNA surveillance pathway_Homo sapiens_hsa030150.63828841
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63243319
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63208299
120Non-small cell lung cancer_Homo sapiens_hsa052230.63143927
121Acute myeloid leukemia_Homo sapiens_hsa052210.62520930
122cAMP signaling pathway_Homo sapiens_hsa040240.58968525
123DNA replication_Homo sapiens_hsa030300.58936632
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58862552
125Tryptophan metabolism_Homo sapiens_hsa003800.58494206
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57298755
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56098998
128Pathways in cancer_Homo sapiens_hsa052000.55134508
129Insulin signaling pathway_Homo sapiens_hsa049100.54844606
130Endocytosis_Homo sapiens_hsa041440.54497718
131Calcium signaling pathway_Homo sapiens_hsa040200.54439428
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54301581
133Fatty acid metabolism_Homo sapiens_hsa012120.54015088
134Proteoglycans in cancer_Homo sapiens_hsa052050.53538386
135ECM-receptor interaction_Homo sapiens_hsa045120.52686232
136Fatty acid elongation_Homo sapiens_hsa000620.52617083
137Phagosome_Homo sapiens_hsa041450.51484809
138Glucagon signaling pathway_Homo sapiens_hsa049220.51336957
139Chronic myeloid leukemia_Homo sapiens_hsa052200.50435852
140Alzheimers disease_Homo sapiens_hsa050100.50424733
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49630002
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49165235
143mTOR signaling pathway_Homo sapiens_hsa041500.48246426
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.48029805
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47228473
146Thyroid hormone synthesis_Homo sapiens_hsa049180.46372025
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46300328
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45575398

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