NXT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.79278878
2DNA deamination (GO:0045006)5.24285527
3DNA strand elongation involved in DNA replication (GO:0006271)4.87756696
4telomere maintenance via semi-conservative replication (GO:0032201)4.77151171
5DNA strand elongation (GO:0022616)4.66293092
6maturation of SSU-rRNA (GO:0030490)4.62512470
7viral transcription (GO:0019083)4.59725347
8translational termination (GO:0006415)4.51268666
9DNA replication initiation (GO:0006270)4.45490015
10regulation of mitochondrial translation (GO:0070129)4.39526542
11telomere maintenance via recombination (GO:0000722)4.34617761
12ribosomal small subunit biogenesis (GO:0042274)4.33437297
13chaperone-mediated protein transport (GO:0072321)4.31144856
14CENP-A containing nucleosome assembly (GO:0034080)4.26299011
15chromatin remodeling at centromere (GO:0031055)4.21698771
16regulation of cellular amino acid metabolic process (GO:0006521)4.18586792
17DNA replication checkpoint (GO:0000076)4.16626111
18translational elongation (GO:0006414)4.07838115
19mitotic recombination (GO:0006312)4.02583943
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98074322
21ribosomal large subunit biogenesis (GO:0042273)3.96951834
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.94710602
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94471905
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.91490681
25mitotic metaphase plate congression (GO:0007080)3.89657799
26cotranslational protein targeting to membrane (GO:0006613)3.87897900
27formation of translation preinitiation complex (GO:0001731)3.87046420
28signal transduction involved in DNA damage checkpoint (GO:0072422)3.86499405
29signal transduction involved in DNA integrity checkpoint (GO:0072401)3.86499405
30protein targeting to ER (GO:0045047)3.85594239
31translational initiation (GO:0006413)3.85422725
32protein localization to kinetochore (GO:0034501)3.82226590
33signal transduction involved in cell cycle checkpoint (GO:0072395)3.81070650
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80582965
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80582965
36DNA replication-independent nucleosome organization (GO:0034724)3.77433974
37DNA replication-independent nucleosome assembly (GO:0006336)3.77433974
38DNA unwinding involved in DNA replication (GO:0006268)3.77083664
39telomere maintenance via telomere lengthening (GO:0010833)3.75498159
40nucleobase biosynthetic process (GO:0046112)3.73464409
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.72998622
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.69598046
43ribonucleoprotein complex biogenesis (GO:0022613)3.68750569
44maturation of 5.8S rRNA (GO:0000460)3.68538039
45protein targeting to mitochondrion (GO:0006626)3.68085755
46purine deoxyribonucleotide catabolic process (GO:0009155)3.66404042
47protein localization to endoplasmic reticulum (GO:0070972)3.65460823
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64232141
49purine nucleobase biosynthetic process (GO:0009113)3.63794839
50kinetochore organization (GO:0051383)3.62973262
51establishment of viral latency (GO:0019043)3.61398435
52protein localization to chromosome, centromeric region (GO:0071459)3.61254921
53protein complex biogenesis (GO:0070271)3.60677078
54deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.59902172
55protein deneddylation (GO:0000338)3.59622351
56histone exchange (GO:0043486)3.59572738
57base-excision repair, AP site formation (GO:0006285)3.58615034
58cullin deneddylation (GO:0010388)3.58153811
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.56581576
60viral life cycle (GO:0019058)3.55030422
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.54882617
62ATP synthesis coupled proton transport (GO:0015986)3.54882617
63proteasome assembly (GO:0043248)3.54588903
64cellular protein complex disassembly (GO:0043624)3.53470117
65deoxyribonucleotide catabolic process (GO:0009264)3.53221069
66deoxyribose phosphate catabolic process (GO:0046386)3.51800282
67spliceosomal snRNP assembly (GO:0000387)3.51351412
68mitochondrial respiratory chain complex assembly (GO:0033108)3.50911253
69GDP-mannose metabolic process (GO:0019673)3.50627587
70positive regulation of ligase activity (GO:0051351)3.46312847
71kinetochore assembly (GO:0051382)3.44998394
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44021085
73mitochondrial respiratory chain complex I assembly (GO:0032981)3.42145872
74NADH dehydrogenase complex assembly (GO:0010257)3.42145872
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42145872
76ribosome biogenesis (GO:0042254)3.40058538
77rRNA processing (GO:0006364)3.39781174
78establishment of protein localization to mitochondrion (GO:0072655)3.39391228
79DNA replication-dependent nucleosome organization (GO:0034723)3.36333025
80DNA replication-dependent nucleosome assembly (GO:0006335)3.36333025
81metaphase plate congression (GO:0051310)3.35829486
82metallo-sulfur cluster assembly (GO:0031163)3.35057379
83iron-sulfur cluster assembly (GO:0016226)3.35057379
84attachment of spindle microtubules to kinetochore (GO:0008608)3.32741997
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31587834
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.31506789
87pseudouridine synthesis (GO:0001522)3.30709272
88protein localization to mitochondrion (GO:0070585)3.30686980
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30026069
90rRNA metabolic process (GO:0016072)3.28895332
91negative regulation of B cell apoptotic process (GO:0002903)3.26832622
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26283080
93purine nucleotide salvage (GO:0032261)3.25946101
94translation (GO:0006412)3.21807920
952-deoxyribonucleotide biosynthetic process (GO:0009265)3.21068492
96deoxyribose phosphate biosynthetic process (GO:0046385)3.21068492
97protein complex disassembly (GO:0043241)3.20407329
98mannosylation (GO:0097502)3.19061458
99regulation of ubiquitin-protein transferase activity (GO:0051438)3.18996167
100mitotic nuclear envelope disassembly (GO:0007077)3.18871251
101viral mRNA export from host cell nucleus (GO:0046784)3.18253805
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.17331966
103respiratory electron transport chain (GO:0022904)3.17015329
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15865009
105pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.14591857
106DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.14038513
107establishment of integrated proviral latency (GO:0075713)3.12521016
108transcription-coupled nucleotide-excision repair (GO:0006283)3.12004382
109electron transport chain (GO:0022900)3.11529324
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.11352044
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10974644
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10595516
113pyrimidine nucleotide catabolic process (GO:0006244)3.10243515
114positive regulation of cell cycle arrest (GO:0071158)3.10118793
115ribosome assembly (GO:0042255)3.09509693
116mitotic chromosome condensation (GO:0007076)3.08038199
1172-deoxyribonucleotide metabolic process (GO:0009394)3.07427181
118rRNA modification (GO:0000154)3.06964438
119regulation of ligase activity (GO:0051340)3.06906971
120nuclear-transcribed mRNA catabolic process (GO:0000956)3.06390601
121regulation of cellular amine metabolic process (GO:0033238)3.06160983
122protein maturation by protein folding (GO:0022417)3.05912181
123GTP biosynthetic process (GO:0006183)3.05292117
124macromolecular complex disassembly (GO:0032984)3.04322973
125tRNA processing (GO:0008033)3.04258141
126negative regulation of ligase activity (GO:0051352)3.04115938
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04115938
128deoxyribose phosphate metabolic process (GO:0019692)3.03988608
129establishment of chromosome localization (GO:0051303)3.03360781
130guanosine-containing compound biosynthetic process (GO:1901070)3.02024023
131cell cycle G1/S phase transition (GO:0044843)3.01292470
132G1/S transition of mitotic cell cycle (GO:0000082)3.01292470
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.98993993
134nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98635162
135peptidyl-histidine modification (GO:0018202)2.98024611
136spliceosomal complex assembly (GO:0000245)2.97936043
137pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96242851
138mRNA catabolic process (GO:0006402)2.91679572
139cellular component biogenesis (GO:0044085)2.91237674
140membrane disassembly (GO:0030397)2.91212272
141nuclear envelope disassembly (GO:0051081)2.91212272
142mitotic sister chromatid segregation (GO:0000070)2.91136357
143telomere organization (GO:0032200)2.89982859
144protein K6-linked ubiquitination (GO:0085020)2.88049872
145telomere maintenance (GO:0000723)2.87864279
146DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87695271
147IMP biosynthetic process (GO:0006188)2.87302551
148RNA catabolic process (GO:0006401)2.86491818
149chromatin assembly or disassembly (GO:0006333)2.84279411
150transcription elongation from RNA polymerase III promoter (GO:0006385)2.83824023
151termination of RNA polymerase III transcription (GO:0006386)2.83824023
152intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83458813
153signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83458813
154folic acid-containing compound biosynthetic process (GO:0009396)2.82093807
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81722347
156signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81722347
157signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81722347
158positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81585424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.94277447
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.24505140
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75610351
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50427887
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.50224370
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42106134
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15847863
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.13760299
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.13292979
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07559807
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92847282
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.89584119
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.84279952
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78993808
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75023196
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72619966
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55786297
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43262899
19XRN2_22483619_ChIP-Seq_HELA_Human2.39017629
20VDR_23849224_ChIP-Seq_CD4+_Human2.37778346
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24961782
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23317536
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21122456
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20613620
25DCP1A_22483619_ChIP-Seq_HELA_Human2.14597182
26FOXP3_21729870_ChIP-Seq_TREG_Human2.07051948
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03160254
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00689347
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00151289
30AR_21909140_ChIP-Seq_LNCAP_Human1.95028294
31* GABP_19822575_ChIP-Seq_HepG2_Human1.92771861
32TTF2_22483619_ChIP-Seq_HELA_Human1.90039167
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85731231
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.85155605
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84730350
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83651386
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82530382
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.80765631
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76589098
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76047414
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75417573
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68724879
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.66084024
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64738158
45* SRF_21415370_ChIP-Seq_HL-1_Mouse1.63540566
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63387784
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61800262
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61713336
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61336340
50ELK1_19687146_ChIP-ChIP_HELA_Human1.58956061
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54804707
52CIITA_25753668_ChIP-Seq_RAJI_Human1.53694116
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52604304
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52192897
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48183176
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47051461
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43731372
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35974073
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33717285
60MYC_22102868_ChIP-Seq_BL_Human1.31374636
61KDM5A_27292631_Chip-Seq_BREAST_Human1.31065390
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27010311
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24357821
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20918941
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18929095
66ZNF263_19887448_ChIP-Seq_K562_Human1.18207260
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.17560483
68SPI1_23547873_ChIP-Seq_NB4_Human1.12412764
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11680891
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11512043
71MYC_18940864_ChIP-ChIP_HL60_Human1.09050299
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07385802
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05942309
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05834532
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04416560
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04378510
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02912343
78* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01730666
79* VDR_21846776_ChIP-Seq_THP-1_Human1.01545442
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01389833
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01258490
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00010740
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99196424
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99002885
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97912070
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96796870
87EGR1_19374776_ChIP-ChIP_THP-1_Human0.95255010
88TFEB_21752829_ChIP-Seq_HELA_Human0.93559416
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91913657
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90205506
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90124623
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.88643708
93FOXP1_21924763_ChIP-Seq_HESCs_Human0.88486033
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87509347
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86423837
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.86205188
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84572483
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83556767
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82853511
100STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82247050
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81585082
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80336788
103* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80125701
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79126857
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77593010
106* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77325416
107MYB_26560356_Chip-Seq_TH2_Human0.77115217
108PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77073292
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76173083
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75228538
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75128351
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74478803
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.73926552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51957509
2MP0010094_abnormal_chromosome_stability4.63182288
3MP0004957_abnormal_blastocyst_morpholog4.19635985
4MP0003111_abnormal_nucleus_morphology4.14336352
5MP0003077_abnormal_cell_cycle3.91928691
6MP0008057_abnormal_DNA_replication3.81206936
7MP0008058_abnormal_DNA_repair3.74010010
8MP0008007_abnormal_cellular_replicative2.89041463
9MP0002396_abnormal_hematopoietic_system2.84626150
10MP0008932_abnormal_embryonic_tissue2.46939902
11MP0008877_abnormal_DNA_methylation2.39753077
12MP0000372_irregular_coat_pigmentation2.31262355
13MP0003123_paternal_imprinting2.18924644
14MP0009697_abnormal_copulation2.14753639
15MP0000490_abnormal_crypts_of2.10643030
16MP0003786_premature_aging2.09275825
17MP0005084_abnormal_gallbladder_morpholo1.94569641
18MP0000350_abnormal_cell_proliferation1.87484055
19MP0001730_embryonic_growth_arrest1.86655187
20MP0003718_maternal_effect1.78728468
21MP0004808_abnormal_hematopoietic_stem1.65327646
22MP0009379_abnormal_foot_pigmentation1.64522750
23MP0003763_abnormal_thymus_physiology1.62271180
24MP0002210_abnormal_sex_determination1.61090455
25MP0005397_hematopoietic_system_phenotyp1.60468962
26MP0001545_abnormal_hematopoietic_system1.60468962
27MP0001529_abnormal_vocalization1.59823028
28MP0001929_abnormal_gametogenesis1.58741104
29MP0002019_abnormal_tumor_incidence1.56793598
30MP0009333_abnormal_splenocyte_physiolog1.55055973
31MP0002132_abnormal_respiratory_system1.54660965
32MP0003806_abnormal_nucleotide_metabolis1.53877998
33MP0000313_abnormal_cell_death1.53565633
34MP0010307_abnormal_tumor_latency1.48109160
35MP0005410_abnormal_fertilization1.41715850
36MP0002398_abnormal_bone_marrow1.38686926
37MP0003186_abnormal_redox_activity1.37782987
38MP0001145_abnormal_male_reproductive1.37364074
39MP0001697_abnormal_embryo_size1.33690744
40MP0001835_abnormal_antigen_presentation1.31521569
41MP0005075_abnormal_melanosome_morpholog1.28511237
42MP0002080_prenatal_lethality1.28055804
43MP0001727_abnormal_embryo_implantation1.27707512
44MP0001672_abnormal_embryogenesis/_devel1.25895664
45MP0005380_embryogenesis_phenotype1.25895664
46MP0002722_abnormal_immune_system1.25756162
47MP0003315_abnormal_perineum_morphology1.25189525
48MP0000653_abnormal_sex_gland1.23968363
49MP0000689_abnormal_spleen_morphology1.23450692
50MP0001905_abnormal_dopamine_level1.21342426
51MP0000703_abnormal_thymus_morphology1.20572067
52MP0002877_abnormal_melanocyte_morpholog1.20311565
53MP0010352_gastrointestinal_tract_polyps1.20036793
54MP0002006_tumorigenesis1.19773794
55MP0006292_abnormal_olfactory_placode1.17843978
56MP0008875_abnormal_xenobiotic_pharmacok1.16320351
57MP0002429_abnormal_blood_cell1.13937105
58MP0001853_heart_inflammation1.11269892
59MP0005408_hypopigmentation1.10631955
60MP0003984_embryonic_growth_retardation1.10020077
61MP0005174_abnormal_tail_pigmentation1.09769497
62MP0006036_abnormal_mitochondrial_physio1.07963154
63MP0005671_abnormal_response_to1.06615028
64MP0008873_increased_physiological_sensi1.06093667
65MP0002088_abnormal_embryonic_growth/wei1.05838940
66MP0002085_abnormal_embryonic_tissue1.05721763
67MP0000716_abnormal_immune_system1.04556192
68MP0001119_abnormal_female_reproductive1.04097633
69MP0002160_abnormal_reproductive_system1.02994560
70MP0002166_altered_tumor_susceptibility1.02870416
71MP0002277_abnormal_respiratory_mucosa1.00777689
72MP0001881_abnormal_mammary_gland1.00302699
73MP0009785_altered_susceptibility_to0.98168259
74MP0003698_abnormal_male_reproductive0.98047468
75MP0000685_abnormal_immune_system0.95101290
76MP0002095_abnormal_skin_pigmentation0.94005453
77MP0001800_abnormal_humoral_immune0.93847774
78MP0006072_abnormal_retinal_apoptosis0.93579606
79MP0002102_abnormal_ear_morphology0.93542333
80MP0000858_altered_metastatic_potential0.93368404
81MP0006054_spinal_hemorrhage0.93083503
82MP0004147_increased_porphyrin_level0.92818027
83MP0002420_abnormal_adaptive_immunity0.92607449
84MP0008872_abnormal_physiological_respon0.92315156
85MP0001819_abnormal_immune_cell0.90726926
86MP0002086_abnormal_extraembryonic_tissu0.90203944
87MP0009764_decreased_sensitivity_to0.89815995
88MP0000358_abnormal_cell_content/0.89549514
89MP0008789_abnormal_olfactory_epithelium0.88664038
90MP0002084_abnormal_developmental_patter0.88040130
91MP0003436_decreased_susceptibility_to0.87191164
92MP0002405_respiratory_system_inflammati0.87136883
93MP0005387_immune_system_phenotype0.86805130
94MP0001790_abnormal_immune_system0.86805130
95MP0003567_abnormal_fetal_cardiomyocyte0.86733118
96MP0005501_abnormal_skin_physiology0.86172947
97MP0002653_abnormal_ependyma_morphology0.86151638
98MP0002452_abnormal_antigen_presenting0.85201929
99MP0005025_abnormal_response_to0.84849214
100MP0005389_reproductive_system_phenotype0.84446230
101MP0005266_abnormal_metabolism0.83053703
102MP0001293_anophthalmia0.82108013
103MP0002723_abnormal_immune_serum0.82073843
104MP0003121_genomic_imprinting0.81300811
105MP0000465_gastrointestinal_hemorrhage0.80783393
106MP0001919_abnormal_reproductive_system0.80448535
107MP0008469_abnormal_protein_level0.80133514
108MP0010030_abnormal_orbit_morphology0.79790260
109MP0004197_abnormal_fetal_growth/weight/0.77345358
110MP0001845_abnormal_inflammatory_respons0.76352760
111MP0002161_abnormal_fertility/fecundity0.73580769
112MP0002938_white_spotting0.72575869
113MP0001873_stomach_inflammation0.72525038
114MP0002148_abnormal_hypersensitivity_rea0.72361284
115MP0001764_abnormal_homeostasis0.71216002
116MP0008260_abnormal_autophagy0.71088781
117MP0005000_abnormal_immune_tolerance0.70328557
118MP0006035_abnormal_mitochondrial_morpho0.70098287
119MP0005451_abnormal_body_composition0.68498250
120MP0010155_abnormal_intestine_physiology0.67960389
121MP0005319_abnormal_enzyme/_coenzyme0.65142828
122MP0005384_cellular_phenotype0.62876061
123MP0008995_early_reproductive_senescence0.62377426
124MP0002419_abnormal_innate_immunity0.62287498
125MP0000477_abnormal_intestine_morphology0.62275615
126MP0003656_abnormal_erythrocyte_physiolo0.62053577
127MP0003866_abnormal_defecation0.59715516
128MP0009278_abnormal_bone_marrow0.59002590
129MP0000015_abnormal_ear_pigmentation0.58079129
130MP0003699_abnormal_female_reproductive0.57925425

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.65136863
2Abnormal number of erythroid precursors (HP:0012131)5.56835960
3Reticulocytopenia (HP:0001896)5.44233486
4Abnormal mitochondria in muscle tissue (HP:0008316)4.85306941
5Acute necrotizing encephalopathy (HP:0006965)4.74975587
6Birth length less than 3rd percentile (HP:0003561)4.73425091
7Acute encephalopathy (HP:0006846)4.23183253
8Aplastic anemia (HP:0001915)4.06082764
9Oral leukoplakia (HP:0002745)3.99734298
10Progressive macrocephaly (HP:0004481)3.67278728
11Chromsome breakage (HP:0040012)3.59758159
12Breast hypoplasia (HP:0003187)3.59692675
13Pallor (HP:0000980)3.52787899
14Macrocytic anemia (HP:0001972)3.50636544
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43915014
16Stomatitis (HP:0010280)3.33844404
17Lactic acidosis (HP:0003128)3.26408292
18Abnormality of the preputium (HP:0100587)3.24598814
19Increased muscle lipid content (HP:0009058)3.23595974
2011 pairs of ribs (HP:0000878)3.16220681
21Renal Fanconi syndrome (HP:0001994)3.16133813
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.13486213
23Thrombocytosis (HP:0001894)3.11633104
24Meckel diverticulum (HP:0002245)3.11131270
25Cerebral edema (HP:0002181)3.08417800
26Exercise intolerance (HP:0003546)3.05809879
27Rough bone trabeculation (HP:0100670)3.04463618
28Abnormality of chromosome stability (HP:0003220)3.02447209
29Colon cancer (HP:0003003)3.00579211
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00576409
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00576409
32Abnormality of the ileum (HP:0001549)2.99213269
33Absent thumb (HP:0009777)2.91472374
34Myelodysplasia (HP:0002863)2.90890932
35Carpal bone hypoplasia (HP:0001498)2.90260518
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.86266716
37Patellar aplasia (HP:0006443)2.79737840
383-Methylglutaconic aciduria (HP:0003535)2.79215319
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76699307
40Abnormality of alanine metabolism (HP:0010916)2.76699307
41Hyperalaninemia (HP:0003348)2.76699307
42Microretrognathia (HP:0000308)2.73307985
43Selective tooth agenesis (HP:0001592)2.70476811
44Bone marrow hypocellularity (HP:0005528)2.69861716
45Pancytopenia (HP:0001876)2.69418390
46Aplasia/Hypoplasia of the patella (HP:0006498)2.68101498
47Duodenal stenosis (HP:0100867)2.61513533
48Small intestinal stenosis (HP:0012848)2.61513533
49IgM deficiency (HP:0002850)2.59837025
50Ragged-red muscle fibers (HP:0003200)2.56190621
51Respiratory failure (HP:0002878)2.52481685
52Premature graying of hair (HP:0002216)2.50913611
53Methylmalonic aciduria (HP:0012120)2.50856053
54Type I transferrin isoform profile (HP:0003642)2.49648177
55Hypoplasia of the pons (HP:0012110)2.47806190
56Abnormality of the anterior horn cell (HP:0006802)2.46416680
57Degeneration of anterior horn cells (HP:0002398)2.46416680
58Dicarboxylic aciduria (HP:0003215)2.44989920
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44989920
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44043807
61Increased serum pyruvate (HP:0003542)2.42307472
62Abnormality of the pons (HP:0007361)2.40325002
63Increased hepatocellular lipid droplets (HP:0006565)2.38856793
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.37774347
65Abnormal spermatogenesis (HP:0008669)2.36742956
66Progressive microcephaly (HP:0000253)2.33524528
67Sloping forehead (HP:0000340)2.32088893
68Progressive muscle weakness (HP:0003323)2.31501785
69CNS demyelination (HP:0007305)2.31335945
70Exertional dyspnea (HP:0002875)2.28820695
71Emotional lability (HP:0000712)2.28414922
72IgG deficiency (HP:0004315)2.26530803
73Cerebral hypomyelination (HP:0006808)2.25831079
74Triphalangeal thumb (HP:0001199)2.23968032
75Testicular atrophy (HP:0000029)2.23371051
76Cellular immunodeficiency (HP:0005374)2.23286825
77Abnormal lung lobation (HP:0002101)2.20152924
78B lymphocytopenia (HP:0010976)2.20051013
79Abnormal trabecular bone morphology (HP:0100671)2.20000564
80Impulsivity (HP:0100710)2.19868497
81Poor head control (HP:0002421)2.19593608
82Elevated erythrocyte sedimentation rate (HP:0003565)2.19424630
83Cleft eyelid (HP:0000625)2.18857905
84Optic disc pallor (HP:0000543)2.17545342
85Increased serum lactate (HP:0002151)2.17459453
86Lipid accumulation in hepatocytes (HP:0006561)2.16387946
87Methylmalonic acidemia (HP:0002912)2.16127752
88Trismus (HP:0000211)2.15652731
89Hepatocellular necrosis (HP:0001404)2.15538430
90Neoplasm of the pancreas (HP:0002894)2.14116648
91Horseshoe kidney (HP:0000085)2.13246778
92Premature ovarian failure (HP:0008209)2.12835047
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12333862
94Tracheoesophageal fistula (HP:0002575)2.11747331
95Muscle fiber atrophy (HP:0100295)2.11164348
96Secondary amenorrhea (HP:0000869)2.09830683
97Abnormality of the duodenum (HP:0002246)2.07015537
98Hypoproteinemia (HP:0003075)2.06426241
99Abnormality of DNA repair (HP:0003254)2.06084952
100Abnormality of reticulocytes (HP:0004312)2.04692588
101Abnormality of glycolysis (HP:0004366)2.04689744
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04623744
103Lethargy (HP:0001254)2.03515229
104Multiple enchondromatosis (HP:0005701)2.02931723
105Petechiae (HP:0000967)2.02683259
106Absent radius (HP:0003974)2.02648029
107Clubbing of toes (HP:0100760)2.02297209
108Neutropenia (HP:0001875)2.01646854
109Type 2 muscle fiber atrophy (HP:0003554)2.00436327
110Supernumerary spleens (HP:0009799)2.00310891
111Pulmonary fibrosis (HP:0002206)2.00180441
112Medulloblastoma (HP:0002885)2.00031547
113Agnosia (HP:0010524)1.99527059
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99519883
115Lymphoma (HP:0002665)1.99336496
116Poikiloderma (HP:0001029)1.99180821
117Opisthotonus (HP:0002179)1.98971049
118Leukodystrophy (HP:0002415)1.97216538
119Severe combined immunodeficiency (HP:0004430)1.92421903
120Reduced antithrombin III activity (HP:0001976)1.92180394
121Constricted visual fields (HP:0001133)1.90458134
122Hepatic necrosis (HP:0002605)1.88347448
123Abnormal protein glycosylation (HP:0012346)1.88275315
124Abnormal glycosylation (HP:0012345)1.88275315
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88275315
126Abnormal protein N-linked glycosylation (HP:0012347)1.88275315
127Increased CSF lactate (HP:0002490)1.86906267
128Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86715713
129Mitochondrial inheritance (HP:0001427)1.86064148
130Aplasia involving forearm bones (HP:0009822)1.85739614
131Absent forearm bone (HP:0003953)1.85739614
132Duplicated collecting system (HP:0000081)1.85295839
133Squamous cell carcinoma (HP:0002860)1.85029047
134Hypoplasia of the radius (HP:0002984)1.83570090
135Microvesicular hepatic steatosis (HP:0001414)1.83477965
136Sparse eyelashes (HP:0000653)1.83078579
137Respiratory difficulties (HP:0002880)1.81166432
138Increased intramyocellular lipid droplets (HP:0012240)1.80968101
139Generalized aminoaciduria (HP:0002909)1.80555290
140Slender long bone (HP:0003100)1.80433903
141Abnormality of B cell number (HP:0010975)1.80296550
142Entropion (HP:0000621)1.79892502
143Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79326289
144Abnormality of T cell physiology (HP:0011840)1.78454891
145Abnormality of the renal collecting system (HP:0004742)1.78439293
146Acute hepatic failure (HP:0006554)1.76261901
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72121344
148Agammaglobulinemia (HP:0004432)1.70549402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.54111084
2BUB14.55347968
3WEE14.30498414
4CDC73.70016412
5STK163.04382776
6EIF2AK13.02562411
7NME22.95134169
8MAP4K22.62884659
9NEK22.58393268
10BRSK22.46753853
11PLK42.42539161
12SRPK12.41991713
13VRK12.28638945
14ACVR1B2.14677279
15CCNB12.11639001
16DYRK32.04003927
17PASK1.99835020
18TLK11.99415002
19EIF2AK31.93825200
20TTK1.90797647
21PLK11.88245279
22LIMK11.76016166
23RPS6KA41.75903048
24TESK21.71903204
25TRIM281.71831564
26AURKB1.63714353
27CDK71.63318361
28NEK11.63142472
29BRSK11.51752596
30ATR1.50839561
31PIM21.50744884
32RPS6KB21.50276086
33MKNK11.44016246
34CSNK1G31.37942752
35NUAK11.35568806
36CHEK21.31419991
37SCYL21.28805180
38MAP4K11.28077465
39PBK1.25395773
40TSSK61.24895818
41ARAF1.24023787
42AURKA1.23007134
43TESK11.21580398
44MAP3K121.16844609
45MAP3K111.08572013
46CDK41.07854206
47MKNK21.06382664
48PLK31.06294089
49MAP3K81.05125908
50DAPK11.04132740
51STK101.02442159
52TGFBR11.01903201
53KDR0.98845168
54CSNK1G10.98730680
55CSNK1A1L0.98061524
56STK40.97267648
57TAOK20.97242997
58PAK40.96306404
59CDK80.95642188
60TEC0.93858973
61IKBKE0.92975203
62CHEK10.90441744
63MATK0.89735657
64BTK0.89061830
65CSNK1G20.88911080
66PIM10.88123377
67EIF2AK20.87119146
68BCKDK0.86276977
69FLT30.85764854
70PDK40.85182582
71PDK30.85182582
72IRAK40.85091168
73ZAK0.81774734
74EEF2K0.81721449
75TAF10.81313028
76KIT0.81083896
77TAOK30.77833503
78CSNK2A10.70124393
79MAP2K30.69092056
80MAPKAPK30.67286240
81BRAF0.66500278
82LRRK20.63870295
83ATM0.63128833
84MAP2K70.61816385
85ZAP700.61025577
86CSNK2A20.60757140
87MAPKAPK50.60518991
88RPS6KA50.59747104
89CLK10.59373806
90PAK10.58435969
91IRAK30.56880950
92CDK20.56102739
93SMG10.55675276
94BCR0.50384850
95CDK90.48548061
96ABL20.47028383
97NME10.45197502
98IKBKB0.44554024
99TXK0.42745585
100JAK30.41966353
101SIK30.39643393
102MAP3K100.39038361
103CDK10.38753891
104TYK20.38708794
105STK38L0.38251608
106BLK0.38247546
107DYRK20.37923299
108DAPK30.37721988
109CSF1R0.36562431
110LYN0.33481376
111EPHA20.32979958
112CDK190.32659342
113ERN10.32066488
114SYK0.31586804
115CDK140.30313407
116MAP3K140.29946800
117NLK0.28667263
118PRKCI0.28391381
119CSNK1A10.28021971
120MAP2K60.27550935
121GRK10.27426686
122ILK0.27156860
123MELK0.27014735
124MAP3K30.25398903
125MST40.25158899
126CDK60.24965943
127RAF10.22959599
128TBK10.22953699
129PDK20.22885583
130GRK60.21017198

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.16046099
2Ribosome_Homo sapiens_hsa030104.36489379
3Mismatch repair_Homo sapiens_hsa034304.20789972
4Proteasome_Homo sapiens_hsa030503.62302489
5Homologous recombination_Homo sapiens_hsa034403.26458930
6RNA polymerase_Homo sapiens_hsa030203.24073354
7Base excision repair_Homo sapiens_hsa034103.21928972
8* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20578049
9Spliceosome_Homo sapiens_hsa030403.16081202
10Nucleotide excision repair_Homo sapiens_hsa034202.80266136
11Pyrimidine metabolism_Homo sapiens_hsa002402.74896568
12* RNA transport_Homo sapiens_hsa030132.70424357
13Cell cycle_Homo sapiens_hsa041102.50718800
14Fanconi anemia pathway_Homo sapiens_hsa034602.35135825
15One carbon pool by folate_Homo sapiens_hsa006702.11233980
16Basal transcription factors_Homo sapiens_hsa030222.04745974
17Non-homologous end-joining_Homo sapiens_hsa034501.92671953
18RNA degradation_Homo sapiens_hsa030181.91000031
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80551159
20Purine metabolism_Homo sapiens_hsa002301.53679106
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52103123
22p53 signaling pathway_Homo sapiens_hsa041151.46336827
23Fatty acid elongation_Homo sapiens_hsa000621.37969932
24Protein export_Homo sapiens_hsa030601.37314028
25Systemic lupus erythematosus_Homo sapiens_hsa053221.28735401
26* mRNA surveillance pathway_Homo sapiens_hsa030151.24075788
27Pentose phosphate pathway_Homo sapiens_hsa000301.18769244
28Sulfur metabolism_Homo sapiens_hsa009201.12127937
29Epstein-Barr virus infection_Homo sapiens_hsa051691.10921708
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08856918
31Folate biosynthesis_Homo sapiens_hsa007901.07885151
32Huntingtons disease_Homo sapiens_hsa050161.02375133
33Herpes simplex infection_Homo sapiens_hsa051680.98786289
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98167614
35Parkinsons disease_Homo sapiens_hsa050120.95510598
36Antigen processing and presentation_Homo sapiens_hsa046120.93677784
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87822601
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.84563283
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.84037141
40Vitamin B6 metabolism_Homo sapiens_hsa007500.80607449
41Oocyte meiosis_Homo sapiens_hsa041140.78740466
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77458488
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76958041
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75774541
45Oxidative phosphorylation_Homo sapiens_hsa001900.75290031
46Sulfur relay system_Homo sapiens_hsa041220.74961751
47Viral carcinogenesis_Homo sapiens_hsa052030.73453750
48Primary immunodeficiency_Homo sapiens_hsa053400.72165165
49Autoimmune thyroid disease_Homo sapiens_hsa053200.71242640
50Selenocompound metabolism_Homo sapiens_hsa004500.69859182
51Glutathione metabolism_Homo sapiens_hsa004800.66001313
52Biosynthesis of amino acids_Homo sapiens_hsa012300.65645823
53Peroxisome_Homo sapiens_hsa041460.65458769
54N-Glycan biosynthesis_Homo sapiens_hsa005100.64994332
55Legionellosis_Homo sapiens_hsa051340.64903560
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63692991
57Cardiac muscle contraction_Homo sapiens_hsa042600.62688617
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61687637
59Graft-versus-host disease_Homo sapiens_hsa053320.61516776
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60283940
61HTLV-I infection_Homo sapiens_hsa051660.56950166
62Rheumatoid arthritis_Homo sapiens_hsa053230.53384102
63Vibrio cholerae infection_Homo sapiens_hsa051100.51465002
64Steroid biosynthesis_Homo sapiens_hsa001000.51293442
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49968856
66Propanoate metabolism_Homo sapiens_hsa006400.48718135
67Type I diabetes mellitus_Homo sapiens_hsa049400.48021423
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47780008
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.47668858
70Measles_Homo sapiens_hsa051620.47061108
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45927176
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42900286
73Carbon metabolism_Homo sapiens_hsa012000.42744463
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42435396
75Asthma_Homo sapiens_hsa053100.42226718
76Thyroid cancer_Homo sapiens_hsa052160.41807739
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.40928532
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39284791
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.38340118
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38177551
81Hematopoietic cell lineage_Homo sapiens_hsa046400.38063333
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37194408
83Metabolic pathways_Homo sapiens_hsa011000.36347252
84Alcoholism_Homo sapiens_hsa050340.36309748
85Apoptosis_Homo sapiens_hsa042100.35636644
86Collecting duct acid secretion_Homo sapiens_hsa049660.35466499
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34509243
88Arachidonic acid metabolism_Homo sapiens_hsa005900.32672028
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32611940
90Shigellosis_Homo sapiens_hsa051310.31414926
91Small cell lung cancer_Homo sapiens_hsa052220.31242490
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29617477
93Alzheimers disease_Homo sapiens_hsa050100.29093453
94Butanoate metabolism_Homo sapiens_hsa006500.27711794
95Fructose and mannose metabolism_Homo sapiens_hsa000510.27630553
96Hepatitis B_Homo sapiens_hsa051610.27373322
97Viral myocarditis_Homo sapiens_hsa054160.27033184
98Galactose metabolism_Homo sapiens_hsa000520.26414180
99Allograft rejection_Homo sapiens_hsa053300.23810650
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23446272
101* Influenza A_Homo sapiens_hsa051640.21634062
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20511816
103Other glycan degradation_Homo sapiens_hsa005110.20336687
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19295384
105Leishmaniasis_Homo sapiens_hsa051400.19276319
106MicroRNAs in cancer_Homo sapiens_hsa052060.17684811
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15711494
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15577639
109Linoleic acid metabolism_Homo sapiens_hsa005910.14970682
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13905187
111Fatty acid metabolism_Homo sapiens_hsa012120.13250165
112Vitamin digestion and absorption_Homo sapiens_hsa049770.13032089
113Renin-angiotensin system_Homo sapiens_hsa046140.11387022
114Pyruvate metabolism_Homo sapiens_hsa006200.10075185
115TGF-beta signaling pathway_Homo sapiens_hsa043500.09153267
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.08714149
117Acute myeloid leukemia_Homo sapiens_hsa052210.08257926
118HIF-1 signaling pathway_Homo sapiens_hsa040660.08073213
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.08068219
120Regulation of autophagy_Homo sapiens_hsa041400.07433586
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.07088075
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04718280
123Notch signaling pathway_Homo sapiens_hsa043300.04069388

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