NXT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.08340826
2L-phenylalanine catabolic process (GO:0006559)5.08340826
3CENP-A containing nucleosome assembly (GO:0034080)4.69051194
4fatty acid elongation (GO:0030497)4.64178866
5protein neddylation (GO:0045116)4.61128598
6chromatin remodeling at centromere (GO:0031055)4.58489436
7axon ensheathment in central nervous system (GO:0032291)4.57527973
8central nervous system myelination (GO:0022010)4.57527973
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.51957457
10L-phenylalanine metabolic process (GO:0006558)4.51957457
11purine nucleobase biosynthetic process (GO:0009113)4.27895695
12establishment of integrated proviral latency (GO:0075713)4.18572559
13IMP biosynthetic process (GO:0006188)4.03359498
14protein localization to kinetochore (GO:0034501)3.94599129
15DNA ligation (GO:0006266)3.88554702
16histone exchange (GO:0043486)3.84342292
17proteasome assembly (GO:0043248)3.78364596
18aromatic amino acid family catabolic process (GO:0009074)3.77834023
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71617702
20DNA replication-independent nucleosome organization (GO:0034724)3.71601396
21DNA replication-independent nucleosome assembly (GO:0006336)3.71601396
22protein localization to chromosome, centromeric region (GO:0071459)3.64519414
23dicarboxylic acid catabolic process (GO:0043649)3.61769149
24DNA strand elongation involved in DNA replication (GO:0006271)3.60482396
25mitotic metaphase plate congression (GO:0007080)3.60275642
26neutrophil activation involved in immune response (GO:0002283)3.53836850
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52708266
28nuclear pore complex assembly (GO:0051292)3.49042852
29telomere maintenance via semi-conservative replication (GO:0032201)3.47793352
30metaphase plate congression (GO:0051310)3.46992818
31DNA strand elongation (GO:0022616)3.45126764
32IMP metabolic process (GO:0046040)3.44431213
33nucleobase biosynthetic process (GO:0046112)3.43095361
34aspartate family amino acid catabolic process (GO:0009068)3.42212671
35very long-chain fatty acid metabolic process (GO:0000038)3.42088827
36coenzyme catabolic process (GO:0009109)3.41417086
37establishment of viral latency (GO:0019043)3.38317877
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37572328
39negative regulation of ligase activity (GO:0051352)3.35960176
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35960176
41glutamate metabolic process (GO:0006536)3.34675516
42establishment of chromosome localization (GO:0051303)3.34025349
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32206346
44bile acid biosynthetic process (GO:0006699)3.32120604
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31942076
46negative regulation of mitotic sister chromatid separation (GO:2000816)3.31810490
47negative regulation of sister chromatid segregation (GO:0033046)3.31810490
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.31810490
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31810490
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.31810490
51spindle checkpoint (GO:0031577)3.31563036
52neurotransmitter-gated ion channel clustering (GO:0072578)3.30717783
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.30483050
54L-amino acid import (GO:0043092)3.28841777
55mitotic spindle checkpoint (GO:0071174)3.28239225
56mitotic G2/M transition checkpoint (GO:0044818)3.26874298
57synaptic vesicle exocytosis (GO:0016079)3.25360895
58negative regulation of chromosome segregation (GO:0051985)3.21500718
59nuclear pore organization (GO:0006999)3.16317880
60C4-dicarboxylate transport (GO:0015740)3.16140713
61mitotic spindle assembly checkpoint (GO:0007094)3.15147166
62formation of translation preinitiation complex (GO:0001731)3.14760217
63ribosome assembly (GO:0042255)3.14414169
64glutamate secretion (GO:0014047)3.12938238
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12418528
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12418528
67spindle assembly checkpoint (GO:0071173)3.12343587
68presynaptic membrane assembly (GO:0097105)3.09823599
69DNA replication checkpoint (GO:0000076)3.09420466
70cellular ketone body metabolic process (GO:0046950)3.08806983
71synapsis (GO:0007129)3.08145664
72gamma-aminobutyric acid transport (GO:0015812)3.07320334
73presynaptic membrane organization (GO:0097090)3.06747298
74neurotransmitter uptake (GO:0001504)3.06189229
75telomere maintenance via recombination (GO:0000722)3.04290449
76folic acid-containing compound biosynthetic process (GO:0009396)3.04261982
77neuron cell-cell adhesion (GO:0007158)3.03772062
78cullin deneddylation (GO:0010388)3.03273417
79kinetochore organization (GO:0051383)3.02969112
80mitotic recombination (GO:0006312)3.02742147
81non-recombinational repair (GO:0000726)3.02647052
82double-strand break repair via nonhomologous end joining (GO:0006303)3.02647052
83response to methylmercury (GO:0051597)3.01395128
84negative regulation of neurotransmitter transport (GO:0051589)3.01192435
85long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.00619215
86mitotic G2 DNA damage checkpoint (GO:0007095)2.99120489
87cofactor catabolic process (GO:0051187)2.98735679
88meiotic chromosome segregation (GO:0045132)2.98082498
89DNA double-strand break processing (GO:0000729)2.96975071
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94487867
91regulation of chromosome segregation (GO:0051983)2.94306181
92regulation of mitotic sister chromatid separation (GO:0010965)2.94285815
93regulation of mitotic sister chromatid segregation (GO:0033047)2.94285815
94regulation of sister chromatid segregation (GO:0033045)2.94285815
95mitotic chromosome condensation (GO:0007076)2.90028342
96purine nucleotide salvage (GO:0032261)2.89847779
97acidic amino acid transport (GO:0015800)2.89834790
98DNA catabolic process, exonucleolytic (GO:0000738)2.89784713
99lysine catabolic process (GO:0006554)2.87934343
100lysine metabolic process (GO:0006553)2.87934343
101fatty-acyl-CoA biosynthetic process (GO:0046949)2.87808679
102regulation of synaptic vesicle exocytosis (GO:2000300)2.86991489
103purine-containing compound salvage (GO:0043101)2.84280015
104DNA topological change (GO:0006265)2.83989744
105attachment of spindle microtubules to kinetochore (GO:0008608)2.80636495
106long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.80180032
107glyoxylate metabolic process (GO:0046487)2.79738658
108DNA replication-dependent nucleosome organization (GO:0034723)2.79606599
109DNA replication-dependent nucleosome assembly (GO:0006335)2.79606599
110mitotic sister chromatid segregation (GO:0000070)2.79229669
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79192265
112negative regulation of DNA-dependent DNA replication (GO:2000104)2.78463642
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.78377632
114short-chain fatty acid metabolic process (GO:0046459)2.77337881
115dicarboxylic acid biosynthetic process (GO:0043650)2.77301365
116protein deneddylation (GO:0000338)2.74790868
117alpha-linolenic acid metabolic process (GO:0036109)2.74551568
118pore complex assembly (GO:0046931)2.74422335
119cysteine metabolic process (GO:0006534)2.74399700
120fatty-acyl-CoA metabolic process (GO:0035337)2.74174468
121G1/S transition of mitotic cell cycle (GO:0000082)2.73437844
122cell cycle G1/S phase transition (GO:0044843)2.73437844
123acyl-CoA biosynthetic process (GO:0071616)2.73282819
124thioester biosynthetic process (GO:0035384)2.73282819
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73159282
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73159282
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73159282
128tyrosine metabolic process (GO:0006570)2.72758187
129alpha-amino acid catabolic process (GO:1901606)2.72591772
130regulation of beta-amyloid formation (GO:1902003)2.72436679
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72351310
132triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.71954081
133amino acid import (GO:0043090)2.71713627
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71124281
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71124281
136peroxisome fission (GO:0016559)2.69712739
137cellular potassium ion homeostasis (GO:0030007)2.69532067
138positive regulation of ligase activity (GO:0051351)2.69035497
139regulation of mitotic spindle checkpoint (GO:1903504)2.68497084
140regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68497084
141L-glutamate transport (GO:0015813)2.68061476
142regulation of cellular amino acid metabolic process (GO:0006521)2.67094293
143bile acid metabolic process (GO:0008206)2.67002968
144ketone body metabolic process (GO:1902224)2.66042092
145sister chromatid segregation (GO:0000819)2.65668132
146Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65527842
147low-density lipoprotein particle remodeling (GO:0034374)2.65386202
148neuronal action potential propagation (GO:0019227)2.65372324
149homocysteine metabolic process (GO:0050667)2.65304141
150regulation of ubiquitin-protein transferase activity (GO:0051438)2.65287002
151antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.64335969
152signal transduction involved in DNA damage checkpoint (GO:0072422)2.64184379
153signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64184379
154cellular amino acid catabolic process (GO:0009063)2.64099656
155indole-containing compound catabolic process (GO:0042436)2.63556929
156indolalkylamine catabolic process (GO:0046218)2.63556929
157tryptophan catabolic process (GO:0006569)2.63556929
158succinate metabolic process (GO:0006105)2.63083647
159DNA unwinding involved in DNA replication (GO:0006268)2.62600547
160aromatic amino acid family metabolic process (GO:0009072)2.61299103
161mitotic sister chromatid cohesion (GO:0007064)2.60925990
162gamma-aminobutyric acid signaling pathway (GO:0007214)2.60073299
163cerebellar granule cell differentiation (GO:0021707)2.59034869
164antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58626600
165regulation of ligase activity (GO:0051340)2.57298781
166transferrin transport (GO:0033572)2.54039783
167thioester metabolic process (GO:0035383)2.53555365
168acyl-CoA metabolic process (GO:0006637)2.53555365
169long-chain fatty acid biosynthetic process (GO:0042759)2.53092574
170ATP hydrolysis coupled proton transport (GO:0015991)2.51778749
171energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.51778749
172sulfur amino acid catabolic process (GO:0000098)2.51505361
173negative regulation of neurotransmitter secretion (GO:0046929)2.51108793
174drug transmembrane transport (GO:0006855)2.50829854
175glutamine family amino acid catabolic process (GO:0009065)2.50534846
176tryptophan metabolic process (GO:0006568)2.49978558
177regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49330342
178ferric iron transport (GO:0015682)2.47305437
179trivalent inorganic cation transport (GO:0072512)2.47305437
180long-term synaptic potentiation (GO:0060291)2.47283584
181reverse cholesterol transport (GO:0043691)2.46496546
182neurotransmitter secretion (GO:0007269)2.45964519
183regulation of lipoprotein metabolic process (GO:0050746)2.45221386
184glutathione biosynthetic process (GO:0006750)2.44691873
185regulation of amyloid precursor protein catabolic process (GO:1902991)2.44652623
186cholesterol biosynthetic process (GO:0006695)2.43940732
187regulation of synaptic vesicle transport (GO:1902803)2.42944498
188regulation of bile acid biosynthetic process (GO:0070857)2.42691517
189glycerophospholipid catabolic process (GO:0046475)2.42536770
190high-density lipoprotein particle remodeling (GO:0034375)2.41685721
191synaptic vesicle maturation (GO:0016188)2.39727966
192negative regulation of protein localization to cell surface (GO:2000009)2.38929191
193vocalization behavior (GO:0071625)2.38889768
194positive regulation of cellular amide metabolic process (GO:0034250)2.38604611
195fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.38529781
196regulation of cholesterol esterification (GO:0010872)2.38272826
197aldehyde catabolic process (GO:0046185)2.37465914
198cellular modified amino acid catabolic process (GO:0042219)2.37425719
199drug catabolic process (GO:0042737)2.36473740
200female mating behavior (GO:0060180)2.35989366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81210070
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04658566
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04381153
4GBX2_23144817_ChIP-Seq_PC3_Human3.96907912
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.22650445
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.09986905
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.07151754
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04715312
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.91841697
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89448181
11TAF15_26573619_Chip-Seq_HEK293_Human2.85353966
12ELK1_19687146_ChIP-ChIP_HELA_Human2.82377162
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.75738551
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63555552
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59784225
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57810571
17EZH2_22144423_ChIP-Seq_EOC_Human2.56110578
18AR_21909140_ChIP-Seq_LNCAP_Human2.50665424
19HOXB4_20404135_ChIP-ChIP_EML_Mouse2.28280850
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25256360
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22661190
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22427648
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22167651
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.16709107
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12841161
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12455091
27VDR_23849224_ChIP-Seq_CD4+_Human2.12379253
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08294818
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05417538
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05382223
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04623579
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01989220
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01750645
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01264990
35EGR1_23403033_ChIP-Seq_LIVER_Mouse2.00152121
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99912083
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.99506560
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98093401
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97399010
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.96072446
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94726346
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93667564
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.92201180
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90896799
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.90465208
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88899723
47P300_19829295_ChIP-Seq_ESCs_Human1.88615560
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86854139
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.86526003
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84195590
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83986572
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.83820182
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82491565
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82320437
55AR_21572438_ChIP-Seq_LNCaP_Human1.81333354
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77277195
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76848554
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76623936
59VDR_22108803_ChIP-Seq_LS180_Human1.75036082
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.74121289
61SMAD4_21799915_ChIP-Seq_A2780_Human1.72085090
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70533467
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70339733
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70199079
65DCP1A_22483619_ChIP-Seq_HELA_Human1.69305904
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69035411
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66475710
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64931764
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63080202
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63080202
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62104075
72ER_23166858_ChIP-Seq_MCF-7_Human1.61563045
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60720712
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.59131980
75FUS_26573619_Chip-Seq_HEK293_Human1.56259770
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55571405
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55571405
78REST_21632747_ChIP-Seq_MESCs_Mouse1.53988837
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53088142
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53088142
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53088142
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49424279
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48724008
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48600544
85* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47483921
86SPI1_23547873_ChIP-Seq_NB4_Human1.47145512
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46621975
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46521700
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45762724
90IGF1R_20145208_ChIP-Seq_DFB_Human1.45377191
91HTT_18923047_ChIP-ChIP_STHdh_Human1.44668686
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43852258
93* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42239171
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42126251
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41593749
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.41143089
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40086692
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.38537279
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37197278
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35874870
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.34631982
102* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34460144
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33575250
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33512202
105TTF2_22483619_ChIP-Seq_HELA_Human1.32645105
106AR_25329375_ChIP-Seq_VCAP_Human1.31817921
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31810578
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30777377
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.29848528
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.29626650
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28816122
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27856738
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27596303
114STAT3_23295773_ChIP-Seq_U87_Human1.27331285
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25275819
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.24367310
117GABP_19822575_ChIP-Seq_HepG2_Human1.22070247
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21477740
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20116851
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18883536
121* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18512495
122TFEB_21752829_ChIP-Seq_HELA_Human1.18480579
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18422208
124NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18270035
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.18082044
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17995702
127EWS_26573619_Chip-Seq_HEK293_Human1.16871762
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16867444
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16655468
130THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16447738
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15397501
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14212411
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.11886187
134EZH2_27294783_Chip-Seq_ESCs_Mouse1.11870132
135XRN2_22483619_ChIP-Seq_HELA_Human1.11497313
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.11456867
137ARNT_22903824_ChIP-Seq_MCF-7_Human1.11136853
138RNF2_27304074_Chip-Seq_ESCs_Mouse1.11009596
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10709632
140RARB_27405468_Chip-Seq_BRAIN_Mouse1.10556498
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10309765
142MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10235997
143P53_22387025_ChIP-Seq_ESCs_Mouse1.08972966
144SOX2_19829295_ChIP-Seq_ESCs_Human1.08942083
145NANOG_19829295_ChIP-Seq_ESCs_Human1.08942083
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08847821
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08743082
148NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08506218
149MYB_26560356_Chip-Seq_TH2_Human1.07795410
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07324020
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07242736
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06830406
153DROSHA_22980978_ChIP-Seq_HELA_Human1.06769662
154TCF4_23295773_ChIP-Seq_U87_Human1.06049256
155TP53_18474530_ChIP-ChIP_U2OS_Human1.04207996
156TAL1_26923725_Chip-Seq_HPCs_Mouse1.04164154
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04095548
158RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03606842
159SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03231955
160NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03216178
161ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03156126
162FLI1_27457419_Chip-Seq_LIVER_Mouse1.02879664
163CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02282814
164PRDM14_20953172_ChIP-Seq_ESCs_Human1.01981629
165SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00765043
166BCAT_22108803_ChIP-Seq_LS180_Human1.00743110
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00674064
168NANOG_16153702_ChIP-ChIP_HESCs_Human1.00534272
169STAT3_18555785_Chip-Seq_ESCs_Mouse1.00486732
170JUN_21703547_ChIP-Seq_K562_Human1.00384608
171P300_18555785_Chip-Seq_ESCs_Mouse1.00337450
172BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00336133
173TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99826682
174WT1_19549856_ChIP-ChIP_CCG9911_Human0.99594501
175AHR_22903824_ChIP-Seq_MCF-7_Human0.99445281
176CBX2_27304074_Chip-Seq_ESCs_Mouse0.99050259
177PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98722686
178STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98492953
179STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98045467
180NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95996196
181SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95024149
182MYC_18940864_ChIP-ChIP_HL60_Human0.94400432
183HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92603196
184POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91407195
185POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90393331
186SOX17_20123909_ChIP-Seq_XEN_Mouse0.89787957
187STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87323728
188TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86310491
189SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84317528
190CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84315606
191SALL4_22934838_ChIP-ChIP_CD34+_Human0.83318716
192IRF8_22096565_ChIP-ChIP_GC-B_Human0.83075486
193* KDM5A_27292631_Chip-Seq_BREAST_Human0.82984512
194NOTCH1_21737748_ChIP-Seq_TLL_Human0.81163308
195GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80918678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.06896934
2MP0010094_abnormal_chromosome_stability3.98674373
3MP0005360_urolithiasis3.80928430
4MP0004957_abnormal_blastocyst_morpholog3.68048864
5MP0003880_abnormal_central_pattern3.61468895
6MP0003693_abnormal_embryo_hatching3.54272935
7MP0008058_abnormal_DNA_repair3.41191844
8MP0008057_abnormal_DNA_replication3.33148843
9MP0003195_calcinosis3.26744974
10MP0003111_abnormal_nucleus_morphology3.14326570
11MP0005085_abnormal_gallbladder_physiolo2.95466571
12MP0003077_abnormal_cell_cycle2.89259308
13MP0008875_abnormal_xenobiotic_pharmacok2.78149587
14MP0008007_abnormal_cellular_replicative2.69130206
15MP0005464_abnormal_platelet_physiology2.63140065
16MP0003690_abnormal_glial_cell2.60550652
17MP0003806_abnormal_nucleotide_metabolis2.58225216
18MP0005646_abnormal_pituitary_gland2.56501507
19MP0005365_abnormal_bile_salt2.51219539
20MP0004043_abnormal_pH_regulation2.47355020
21MP0008932_abnormal_embryonic_tissue2.41102037
22MP0002064_seizures2.38916885
23MP0004859_abnormal_synaptic_plasticity2.29888363
24MP0004270_analgesia2.29039671
25MP0009046_muscle_twitch2.28824648
26MP0003329_amyloid_beta_deposits2.28779730
27MP0003635_abnormal_synaptic_transmissio2.14708358
28MP0002272_abnormal_nervous_system2.12362166
29MP0005332_abnormal_amino_acid2.11062338
30MP0009745_abnormal_behavioral_response2.10437185
31MP0000920_abnormal_myelination2.08131236
32MP0001486_abnormal_startle_reflex2.01233993
33MP0001835_abnormal_antigen_presentation1.99882847
34MP0002736_abnormal_nociception_after1.99536544
35MP0002009_preneoplasia1.87720795
36MP0001968_abnormal_touch/_nociception1.87714119
37MP0003941_abnormal_skin_development1.84366245
38MP0002148_abnormal_hypersensitivity_rea1.83722206
39MP0002063_abnormal_learning/memory/cond1.82294507
40MP0002572_abnormal_emotion/affect_behav1.78064648
41MP0009785_altered_susceptibility_to1.76899280
42MP0010307_abnormal_tumor_latency1.75905204
43MP0002734_abnormal_mechanical_nocicepti1.75384964
44MP0009333_abnormal_splenocyte_physiolog1.74798429
45MP0002396_abnormal_hematopoietic_system1.74556677
46MP0001853_heart_inflammation1.74318873
47MP0001529_abnormal_vocalization1.72954071
48MP0005671_abnormal_response_to1.70738662
49MP0001984_abnormal_olfaction1.70041669
50MP0002006_tumorigenesis1.68932320
51MP0003718_maternal_effect1.66797802
52MP0004142_abnormal_muscle_tone1.66700323
53MP0000604_amyloidosis1.65127067
54MP0006082_CNS_inflammation1.63210248
55MP0003724_increased_susceptibility_to1.61436996
56MP0003252_abnormal_bile_duct1.60878289
57MP0009780_abnormal_chondrocyte_physiolo1.60424400
58MP0003448_altered_tumor_morphology1.59136177
59MP0000350_abnormal_cell_proliferation1.57518605
60MP0002876_abnormal_thyroid_physiology1.53405634
61MP0010329_abnormal_lipoprotein_level1.49989424
62MP0001730_embryonic_growth_arrest1.49617643
63MP0001440_abnormal_grooming_behavior1.49215958
64MP0003633_abnormal_nervous_system1.48993239
65MP0004885_abnormal_endolymph1.48629678
66MP0002067_abnormal_sensory_capabilities1.47375125
67MP0002166_altered_tumor_susceptibility1.47209899
68MP0006054_spinal_hemorrhage1.46190502
69MP0003303_peritoneal_inflammation1.45890706
70MP0005551_abnormal_eye_electrophysiolog1.42541346
71MP0002398_abnormal_bone_marrow1.40507006
72MP0001501_abnormal_sleep_pattern1.38029053
73MP0002877_abnormal_melanocyte_morpholog1.37837964
74MP0002452_abnormal_antigen_presenting1.36442034
75MP0003786_premature_aging1.35075626
76MP0005000_abnormal_immune_tolerance1.32086280
77MP0008877_abnormal_DNA_methylation1.31958764
78MP0003631_nervous_system_phenotype1.31627054
79MP0000343_altered_response_to1.31625573
80MP0002229_neurodegeneration1.31576352
81MP0008004_abnormal_stomach_pH1.30690744
82MP0000689_abnormal_spleen_morphology1.29965504
83MP0002735_abnormal_chemical_nociception1.29776586
84MP0002822_catalepsy1.29254579
85MP0003634_abnormal_glial_cell1.29158057
86MP0002132_abnormal_respiratory_system1.29060183
87MP0002019_abnormal_tumor_incidence1.29048151
88MP0009840_abnormal_foam_cell1.28908205
89MP0004808_abnormal_hematopoietic_stem1.28204089
90MP0001800_abnormal_humoral_immune1.27426956
91MP0000313_abnormal_cell_death1.27233007
92MP0002419_abnormal_innate_immunity1.26253651
93MP0010352_gastrointestinal_tract_polyps1.25772203
94MP0001905_abnormal_dopamine_level1.25578296
95MP0001970_abnormal_pain_threshold1.24798794
96MP0000858_altered_metastatic_potential1.24358740
97MP0002723_abnormal_immune_serum1.23510394
98MP0002722_abnormal_immune_system1.22015892
99MP0002090_abnormal_vision1.21859655
100MP0002420_abnormal_adaptive_immunity1.20437768
101MP0002118_abnormal_lipid_homeostasis1.19860836
102MP0001819_abnormal_immune_cell1.19512845
103MP0003221_abnormal_cardiomyocyte_apopto1.19245553
104MP0003632_abnormal_nervous_system1.18986309
105MP0006035_abnormal_mitochondrial_morpho1.18792180
106MP0001697_abnormal_embryo_size1.18240438
107MP0003191_abnormal_cellular_cholesterol1.15676583
108MP0002733_abnormal_thermal_nociception1.15615756
109MP0005171_absent_coat_pigmentation1.15594729
110MP0005584_abnormal_enzyme/coenzyme_acti1.15213237
111MP0005025_abnormal_response_to1.14600727
112MP0004742_abnormal_vestibular_system1.14565493
113MP0000358_abnormal_cell_content/1.13980626
114MP0004019_abnormal_vitamin_homeostasis1.13967234
115MP0005083_abnormal_biliary_tract1.12909178
116MP0003656_abnormal_erythrocyte_physiolo1.11688936
117MP0005386_behavior/neurological_phenoty1.09737330
118MP0004924_abnormal_behavior1.09737330
119MP0003950_abnormal_plasma_membrane1.09715430
120MP0005423_abnormal_somatic_nervous1.09345180
121MP0004147_increased_porphyrin_level1.09068804
122MP0002405_respiratory_system_inflammati1.08096769
123MP0002429_abnormal_blood_cell1.07984749
124MP0009697_abnormal_copulation1.07942520
125MP0006276_abnormal_autonomic_nervous1.07047535
126MP0001177_atelectasis1.06960206
127MP0003186_abnormal_redox_activity1.06444896
128MP0009763_increased_sensitivity_to1.06267430
129MP0001764_abnormal_homeostasis1.05792553
130MP0004947_skin_inflammation1.05710778
131MP0000716_abnormal_immune_system1.04229624
132MP0001545_abnormal_hematopoietic_system1.03622810
133MP0005397_hematopoietic_system_phenotyp1.03622810
134MP0005501_abnormal_skin_physiology1.03343000
135MP0005535_abnormal_body_temperature1.02731224
136MP0001485_abnormal_pinna_reflex1.02439570
137MP0000490_abnormal_crypts_of1.02345973
138MP0000013_abnormal_adipose_tissue1.02160843
139MP0005380_embryogenesis_phenotype1.02063527
140MP0001672_abnormal_embryogenesis/_devel1.02063527
141MP0000566_synostosis1.01836007
142MP0003183_abnormal_peptide_metabolism1.00955570
143MP0001963_abnormal_hearing_physiology1.00930964
144MP0000465_gastrointestinal_hemorrhage1.00647173
145MP0009765_abnormal_xenobiotic_induced1.00415679
146MP0003890_abnormal_embryonic-extraembry1.00210557
147MP0001666_abnormal_nutrient_absorption0.99874263
148MP0001845_abnormal_inflammatory_respons0.99208733
149MP0002796_impaired_skin_barrier0.99035025
150MP0002066_abnormal_motor_capabilities/c0.98648626
151MP0002080_prenatal_lethality0.97460019
152MP0001502_abnormal_circadian_rhythm0.96722331
153MP0009764_decreased_sensitivity_to0.96513114
154MP0005645_abnormal_hypothalamus_physiol0.95988644
155MP0000703_abnormal_thymus_morphology0.95944087
156MP0010155_abnormal_intestine_physiology0.95270915
157MP0003075_altered_response_to0.94847167
158MP0001986_abnormal_taste_sensitivity0.94741749
159MP0008569_lethality_at_weaning0.93247641
160MP0005058_abnormal_lysosome_morphology0.92298930
161MP0001790_abnormal_immune_system0.90669042
162MP0005387_immune_system_phenotype0.90669042
163MP0003984_embryonic_growth_retardation0.90618080
164MP0002557_abnormal_social/conspecific_i0.90324866
165MP0003453_abnormal_keratinocyte_physiol0.88367732
166MP0001929_abnormal_gametogenesis0.88003840
167MP0003879_abnormal_hair_cell0.87717846
168MP0002882_abnormal_neuron_morphology0.87646905
169MP0001191_abnormal_skin_condition0.87182842
170MP0003868_abnormal_feces_composition0.86648957
171MP0005084_abnormal_gallbladder_morpholo0.86590797
172MP0002088_abnormal_embryonic_growth/wei0.85360866
173MP0000778_abnormal_nervous_system0.84711160
174MP0001293_anophthalmia0.83668541
175MP0002210_abnormal_sex_determination0.83013986
176MP0002086_abnormal_extraembryonic_tissu0.82514708
177MP0005384_cellular_phenotype0.81455256
178MP0005621_abnormal_cell_physiology0.80318048
179MP0003011_delayed_dark_adaptation0.79848328
180MP0003763_abnormal_thymus_physiology0.79323816
181MP0002837_dystrophic_cardiac_calcinosis0.78673039
182MP0000639_abnormal_adrenal_gland0.77221677
183MP0001145_abnormal_male_reproductive0.75433102
184MP0008260_abnormal_autophagy0.75215612
185MP0005408_hypopigmentation0.75162657
186MP0000955_abnormal_spinal_cord0.75075023
187MP0008872_abnormal_physiological_respon0.73586984
188MP0006036_abnormal_mitochondrial_physio0.72916375
189MP0010386_abnormal_urinary_bladder0.72787318
190MP0000230_abnormal_systemic_arterial0.71233065
191MP0004858_abnormal_nervous_system0.68376920
192MP0003136_yellow_coat_color0.68055298

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.26236340
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.22631269
3Focal motor seizures (HP:0011153)3.84450436
4Chromsome breakage (HP:0040012)3.81931855
5Intrahepatic cholestasis (HP:0001406)3.67465818
6Abnormality of chromosome stability (HP:0003220)3.40498297
7Pheochromocytoma (HP:0002666)3.38573881
8Hyperventilation (HP:0002883)3.35153585
9Neurofibrillary tangles (HP:0002185)3.30371930
10Atonic seizures (HP:0010819)3.11416275
11Autoimmune hemolytic anemia (HP:0001890)3.09520805
12Petechiae (HP:0000967)3.08399910
13Abnormal lung lobation (HP:0002101)3.06709108
14Xanthomatosis (HP:0000991)3.05110838
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99048152
16Degeneration of the lateral corticospinal tracts (HP:0002314)2.99048152
17Neuroendocrine neoplasm (HP:0100634)2.98662669
18Myokymia (HP:0002411)2.97113818
19Abnormality of the preputium (HP:0100587)2.93138340
20Short middle phalanx of the 5th finger (HP:0004220)2.91146683
21Meckel diverticulum (HP:0002245)2.90231989
22Increased IgM level (HP:0003496)2.80135851
23Nausea (HP:0002018)2.79224373
24Epileptic encephalopathy (HP:0200134)2.78735001
25Sensorimotor neuropathy (HP:0007141)2.74095898
26Nephroblastoma (Wilms tumor) (HP:0002667)2.71879530
27Increased serum pyruvate (HP:0003542)2.70240344
28Abnormality of glycolysis (HP:0004366)2.70240344
29Cholecystitis (HP:0001082)2.70117517
30Abnormal gallbladder physiology (HP:0012438)2.70117517
31Hyperlipoproteinemia (HP:0010980)2.70078882
32Duodenal stenosis (HP:0100867)2.67705762
33Small intestinal stenosis (HP:0012848)2.67705762
34Rhabdomyosarcoma (HP:0002859)2.65744104
35Abnormality of methionine metabolism (HP:0010901)2.64267796
36Embryonal renal neoplasm (HP:0011794)2.63835735
37Acute encephalopathy (HP:0006846)2.63596108
38Hyperglycinemia (HP:0002154)2.63421904
39Termporal pattern (HP:0011008)2.63183479
40Insidious onset (HP:0003587)2.63183479
41Abnormality of glycine metabolism (HP:0010895)2.62916690
42Abnormality of serine family amino acid metabolism (HP:0010894)2.62916690
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62413868
44Abnormality of the ileum (HP:0001549)2.62048223
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.61857358
46Hypobetalipoproteinemia (HP:0003563)2.61392493
47Aplastic anemia (HP:0001915)2.61099467
48Myelodysplasia (HP:0002863)2.60742373
49Gout (HP:0001997)2.59462894
50Increased circulating renin level (HP:0000848)2.57348682
51Dyschromatopsia (HP:0007641)2.56833046
52Complement deficiency (HP:0004431)2.56570277
53Metabolic alkalosis (HP:0200114)2.52372710
54B lymphocytopenia (HP:0010976)2.52235759
55Prolonged partial thromboplastin time (HP:0003645)2.51986162
56Multiple enchondromatosis (HP:0005701)2.50628883
57Hypokalemic alkalosis (HP:0001949)2.50247249
58Deep venous thrombosis (HP:0002625)2.49785105
59Increased mean platelet volume (HP:0011877)2.49193367
60Abnormality of the corticospinal tract (HP:0002492)2.48303212
61Scanning speech (HP:0002168)2.47057074
62Absence seizures (HP:0002121)2.40932158
63Abnormal umbilical cord blood vessels (HP:0011403)2.38972469
64Single umbilical artery (HP:0001195)2.38972469
65Abnormality of the fetal cardiovascular system (HP:0010948)2.38972469
66Cerebral inclusion bodies (HP:0100314)2.38221629
67Medulloblastoma (HP:0002885)2.37893436
68Abnormality of the prostate (HP:0008775)2.37622545
69Cerebral edema (HP:0002181)2.35593469
70Generalized tonic-clonic seizures (HP:0002069)2.35499653
71Focal seizures (HP:0007359)2.33563288
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33331386
73Acute necrotizing encephalopathy (HP:0006965)2.33100699
74Abnormal platelet volume (HP:0011876)2.32620865
75Ovarian neoplasm (HP:0100615)2.32027381
76Ketosis (HP:0001946)2.32020083
77Abnormal mitochondria in muscle tissue (HP:0008316)2.31457694
78Dialeptic seizures (HP:0011146)2.30854451
79Action tremor (HP:0002345)2.30291305
80Agnosia (HP:0010524)2.29753223
81Fat malabsorption (HP:0002630)2.28941489
82Prolonged bleeding time (HP:0003010)2.28476445
83Hyperammonemia (HP:0001987)2.27901096
84Cerebral hemorrhage (HP:0001342)2.26759713
85Hepatosplenomegaly (HP:0001433)2.26583595
86Abnormality of B cell number (HP:0010975)2.26017082
87Paralysis (HP:0003470)2.25256657
88Biliary tract neoplasm (HP:0100574)2.24563369
89Oral leukoplakia (HP:0002745)2.24395626
90Conjugated hyperbilirubinemia (HP:0002908)2.23748773
91Febrile seizures (HP:0002373)2.22669593
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22655879
93Abnormality of alanine metabolism (HP:0010916)2.22655879
94Hyperalaninemia (HP:0003348)2.22655879
95Increased hepatocellular lipid droplets (HP:0006565)2.22436582
96Colon cancer (HP:0003003)2.22392321
97Neoplasm of the colon (HP:0100273)2.21455668
98Clubbing of toes (HP:0100760)2.21424760
99Abnormality of sulfur amino acid metabolism (HP:0004339)2.19479606
100Papillary thyroid carcinoma (HP:0002895)2.19341348
101Leukodystrophy (HP:0002415)2.18692108
102Progressive macrocephaly (HP:0004481)2.17629561
103Abnormality of the anterior horn cell (HP:0006802)2.17330149
104Degeneration of anterior horn cells (HP:0002398)2.17330149
105Renal Fanconi syndrome (HP:0001994)2.15208118
106Pancytopenia (HP:0001876)2.14933207
107Blue irides (HP:0000635)2.14357600
108Alkalosis (HP:0001948)2.14064155
109Split foot (HP:0001839)2.13829866
110Birth length less than 3rd percentile (HP:0003561)2.13542157
111Dysmetria (HP:0001310)2.12175206
112IgM deficiency (HP:0002850)2.12038677
113Lethargy (HP:0001254)2.11783705
114Dysdiadochokinesis (HP:0002075)2.11660193
115Hypomagnesemia (HP:0002917)2.11442946
116Type I transferrin isoform profile (HP:0003642)2.10852019
117Progressive external ophthalmoplegia (HP:0000590)2.10811302
118Ketoacidosis (HP:0001993)2.10044377
119Abnormal eating behavior (HP:0100738)2.09528830
120Hyperglycinuria (HP:0003108)2.06854383
121Intention tremor (HP:0002080)2.06796922
122Carpal bone hypoplasia (HP:0001498)2.06500928
123Recurrent abscess formation (HP:0002722)2.06053632
124Reticulocytopenia (HP:0001896)2.05397097
125Recurrent bacterial skin infections (HP:0005406)2.05284062
126Abnormal gallbladder morphology (HP:0012437)2.04272718
127Abnormality of the duodenum (HP:0002246)2.03503634
128Purpura (HP:0000979)2.03501330
129Amaurosis fugax (HP:0100576)2.02274445
130Methylmalonic acidemia (HP:0002912)2.01398275
131Prostate neoplasm (HP:0100787)2.00093078
132Vacuolated lymphocytes (HP:0001922)1.99505920
133Mediastinal lymphadenopathy (HP:0100721)1.99417714
134Gonadal dysgenesis (HP:0000133)1.99388269
135Neoplasm of the small intestine (HP:0100833)1.98563236
136Aplasia involving bones of the upper limbs (HP:0009823)1.97943618
137Aplasia of the phalanges of the hand (HP:0009802)1.97943618
138Aplasia involving bones of the extremities (HP:0009825)1.97943618
139Abnormality of macrophages (HP:0004311)1.97487141
140Steatorrhea (HP:0002570)1.97430487
141Generalized myoclonic seizures (HP:0002123)1.97417148
142Epileptiform EEG discharges (HP:0011182)1.96853034
143Lymphoma (HP:0002665)1.96543437
144Recurrent viral infections (HP:0004429)1.96277573
145Status epilepticus (HP:0002133)1.96139828
146Abnormality of fatty-acid metabolism (HP:0004359)1.95829555
147Reduced antithrombin III activity (HP:0001976)1.94080936
148Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93388276
149Spastic paraparesis (HP:0002313)1.92858853
150Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92801077
151Systemic lupus erythematosus (HP:0002725)1.92726673
152Progressive cerebellar ataxia (HP:0002073)1.92551880
153Neoplasm of the rectum (HP:0100743)1.92025881
154Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91803316
155Volvulus (HP:0002580)1.91170820
156Abnormality of serum amino acid levels (HP:0003112)1.90550370
157Abnormality of the umbilical cord (HP:0010881)1.90031348
158EEG with generalized epileptiform discharges (HP:0011198)1.88349332
159Combined immunodeficiency (HP:0005387)1.88277191
160Epidermoid cyst (HP:0200040)1.87895799
161Autoimmune thrombocytopenia (HP:0001973)1.87314940
162Hypolipoproteinemia (HP:0010981)1.86972583
163Thyroid carcinoma (HP:0002890)1.86647672
164Irritability (HP:0000737)1.86091218
165Autoamputation (HP:0001218)1.85560343
166Conjunctival telangiectasia (HP:0000524)1.85379879
167Gait imbalance (HP:0002141)1.84865315
168Abnormal hair whorl (HP:0010721)1.84848654
169Stomatitis (HP:0010280)1.84651027
170Abnormal auditory evoked potentials (HP:0006958)1.84613193
171Sloping forehead (HP:0000340)1.84534312
172Anxiety (HP:0000739)1.83059701
173Peripheral hypomyelination (HP:0007182)1.82618548
174Bone marrow hypocellularity (HP:0005528)1.82422057
175Epiphyseal stippling (HP:0010655)1.82394039
176Uterine neoplasm (HP:0010784)1.81182213
177Fair hair (HP:0002286)1.80802627
178Segmental peripheral demyelination/remyelination (HP:0003481)1.80771262
179Mitochondrial inheritance (HP:0001427)1.80440217
180Spastic gait (HP:0002064)1.80348901
181Medial flaring of the eyebrow (HP:0010747)1.80190628
182Ascites (HP:0001541)1.79937304
183Neoplasm of the pancreas (HP:0002894)1.79441651
184Paraparesis (HP:0002385)1.79377554
185Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78216246
186Thrombocytosis (HP:0001894)1.77974167
187Exertional dyspnea (HP:0002875)1.77967256
188Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.77010727
189Lipid accumulation in hepatocytes (HP:0006561)1.76503964
190Respiratory difficulties (HP:0002880)1.71837654
191Median cleft lip (HP:0000161)1.71445888
192Abnormal protein N-linked glycosylation (HP:0012347)1.69503717
193Abnormal protein glycosylation (HP:0012346)1.69503717
194Abnormal glycosylation (HP:0012345)1.69503717
195Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69503717

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.59326649
2OXSR13.76976332
3BUB13.70472947
4STK393.07554463
5EIF2AK32.94096740
6CDC72.84268424
7TTK2.78607492
8SRPK12.71532206
9EIF2AK12.59843068
10PLK42.45787349
11MKNK12.34144510
12BRSK22.23210677
13TRIM282.17342294
14MAP2K72.15836198
15ACVR1B2.15169984
16SGK4942.13752201
17SGK2232.13752201
18EPHA42.13355002
19VRK22.09810933
20PLK32.08012631
21MAP3K42.04511627
22WEE12.01200678
23WNK41.97259234
24NEK11.96314903
25PRPF4B1.96043108
26NTRK31.91356360
27MKNK21.88123169
28ZAK1.87024067
29ERBB41.83423243
30VRK11.82715163
31NUAK11.81582013
32MAP3K121.81308407
33PLK21.80463417
34MAPKAPK51.77274409
35WNK31.73432490
36CDK191.73190266
37AKT31.70998531
38PBK1.66858923
39MAP2K41.64038337
40ARAF1.58099141
41NME21.55784306
42BMPR1B1.54481833
43PDK21.52373205
44STK241.47348971
45BCR1.44672968
46NTRK11.43012856
47PDK41.41409900
48PDK31.41409900
49FGFR21.40594575
50CAMK2B1.37630886
51BCKDK1.31626532
52SCYL21.28933104
53PLK11.27218898
54GRK51.26397633
55DAPK21.23553685
56MINK11.21965627
57TAF11.21468964
58IRAK21.20919636
59SGK21.20725779
60INSRR1.20574394
61PKN11.18684308
62MAP3K91.17689042
63TEC1.15598724
64WNK11.14567010
65CAMK2A1.13180218
66CAMK2G1.12950544
67CAMK2D1.12863821
68STK31.11622535
69EPHB11.10509086
70MST41.10507713
71PINK11.08518590
72CDK61.08076093
73BMPR21.07528226
74PRKCG1.06872437
75MET1.06507403
76RPS6KA41.05110009
77MAPK151.04256229
78ATR1.03660975
79IRAK11.03622365
80PRKCE1.03566249
81STK101.03466962
82PAK61.02957153
83ERBB30.98268935
84LIMK10.97350173
85RIPK40.97004327
86CDK50.93244621
87EIF2AK20.92028926
88TESK20.91090390
89AURKB0.90935388
90STK160.90932661
91DYRK30.89327104
92MAP3K140.88956443
93NTRK20.85854833
94FRK0.85058027
95CSNK1G20.84835327
96KSR20.81359139
97PAK30.80648094
98SIK30.80481754
99CSNK1G30.80074457
100NEK60.79887835
101ADRBK20.79835406
102CHEK20.79739570
103GRK70.79660937
104BRAF0.79304522
105MATK0.78673132
106BRSK10.78254630
107NEK90.77880431
108TGFBR10.77811928
109IRAK30.75777689
110KDR0.75641098
111STK40.75357603
112PDPK10.69914654
113TNIK0.69836206
114CAMKK20.68821428
115PAK40.68088438
116SGK30.68013737
117CSF1R0.67630812
118CDK70.66866059
119IKBKB0.66098950
120MAP3K130.65108623
121BTK0.64954229
122TAOK20.64881953
123FLT30.64318524
124PHKG10.64028698
125PHKG20.64028698
126MAP3K80.63815837
127PASK0.63709853
128UHMK10.62197033
129MAP3K20.61489464
130ALK0.59656091
131TYK20.59408651
132CLK10.59364609
133ATM0.58816449
134CDK140.57572254
135CHEK10.57028681
136BMX0.56910609
137MARK10.56272526
138MAPK130.54887488
139MAPK120.54759724
140CSNK1A1L0.53933877
141CDK40.53761045
142PDK10.53313534
143NLK0.53302241
144MAPK70.53039129
145IRAK40.52474164
146FGR0.52433687
147CDK180.52323463
148LYN0.52208357
149CDK90.51825247
150CSNK2A10.50226363
151NME10.49849858
152PRKD30.49746848
153CDK150.49501828
154PRKCH0.49396441
155PRKCQ0.49227902
156ROCK20.48921993
157PIM10.48190865
158CCNB10.47834699
159TAOK30.47758995
160MAP3K50.46716376
161TSSK60.46590379
162SGK10.46494186
163RPS6KB20.45780032
164AURKA0.45338908
165PRKACA0.45265958
166BLK0.44182117
167CSNK1G10.43564375
168CDK80.41683920
169YES10.41471535
170DYRK1A0.41158289
171PRKCA0.41121587
172NEK20.40887968
173PAK10.40616126
174SYK0.40604075
175PIK3CA0.39695645
176CSNK2A20.39614847
177MARK30.39314950
178ILK0.38367119
179DAPK10.37866839
180PRKACB0.36657772
181IKBKE0.36081563
182STK38L0.36081439
183TBK10.34199725

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.27266196
2Mismatch repair_Homo sapiens_hsa034304.01313425
3DNA replication_Homo sapiens_hsa030303.85074789
4Nitrogen metabolism_Homo sapiens_hsa009103.67225130
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.93743917
6* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64854925
7Non-homologous end-joining_Homo sapiens_hsa034502.62911920
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56329246
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.54957908
10Homologous recombination_Homo sapiens_hsa034402.47093614
11Fatty acid elongation_Homo sapiens_hsa000622.45085953
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41113136
13Butanoate metabolism_Homo sapiens_hsa006502.37857769
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28868251
15Cell cycle_Homo sapiens_hsa041102.25529782
16Nucleotide excision repair_Homo sapiens_hsa034202.12676707
17Arginine biosynthesis_Homo sapiens_hsa002202.04911246
18Sulfur metabolism_Homo sapiens_hsa009202.03598595
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02513328
20Spliceosome_Homo sapiens_hsa030402.01296377
21Base excision repair_Homo sapiens_hsa034102.01024997
22Fanconi anemia pathway_Homo sapiens_hsa034601.99741802
23Collecting duct acid secretion_Homo sapiens_hsa049661.92102183
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.90240777
25Propanoate metabolism_Homo sapiens_hsa006401.83102307
26* RNA transport_Homo sapiens_hsa030131.81388234
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78788617
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77787666
29Steroid biosynthesis_Homo sapiens_hsa001001.76500229
30Synaptic vesicle cycle_Homo sapiens_hsa047211.75876568
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74772553
32Legionellosis_Homo sapiens_hsa051341.73887218
33Pyruvate metabolism_Homo sapiens_hsa006201.72285376
34Peroxisome_Homo sapiens_hsa041461.72174245
35Vitamin B6 metabolism_Homo sapiens_hsa007501.71643558
36RNA polymerase_Homo sapiens_hsa030201.71442915
37Ribosome_Homo sapiens_hsa030101.69413386
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66520900
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66217299
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65908565
41Nicotine addiction_Homo sapiens_hsa050331.62106790
42One carbon pool by folate_Homo sapiens_hsa006701.57441489
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56301511
44Histidine metabolism_Homo sapiens_hsa003401.54887712
45Fatty acid metabolism_Homo sapiens_hsa012121.53162912
46Fatty acid degradation_Homo sapiens_hsa000711.49135070
47GABAergic synapse_Homo sapiens_hsa047271.47167590
48Pyrimidine metabolism_Homo sapiens_hsa002401.44770940
49Basal transcription factors_Homo sapiens_hsa030221.41789801
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35824758
51RNA degradation_Homo sapiens_hsa030181.35716038
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30650600
53Tryptophan metabolism_Homo sapiens_hsa003801.28980983
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26074226
55Oxidative phosphorylation_Homo sapiens_hsa001901.25696022
56Complement and coagulation cascades_Homo sapiens_hsa046101.22410014
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20429446
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20388859
59Vibrio cholerae infection_Homo sapiens_hsa051101.14596721
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14306528
61beta-Alanine metabolism_Homo sapiens_hsa004101.13473673
62p53 signaling pathway_Homo sapiens_hsa041151.13003112
63Bile secretion_Homo sapiens_hsa049761.12530024
64Chemical carcinogenesis_Homo sapiens_hsa052041.10435495
65Antigen processing and presentation_Homo sapiens_hsa046121.07289166
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.07197037
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06639075
68Graft-versus-host disease_Homo sapiens_hsa053321.03461344
69Shigellosis_Homo sapiens_hsa051311.02750237
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02564926
71Asthma_Homo sapiens_hsa053101.01312557
72Retinol metabolism_Homo sapiens_hsa008301.01069492
73Hematopoietic cell lineage_Homo sapiens_hsa046400.98807296
74Morphine addiction_Homo sapiens_hsa050320.98455899
75Glutamatergic synapse_Homo sapiens_hsa047240.98240434
76Herpes simplex infection_Homo sapiens_hsa051680.97798725
77Primary immunodeficiency_Homo sapiens_hsa053400.97232563
78Purine metabolism_Homo sapiens_hsa002300.97033212
79PPAR signaling pathway_Homo sapiens_hsa033200.96706315
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.96483558
81Epstein-Barr virus infection_Homo sapiens_hsa051690.94616731
82Carbon metabolism_Homo sapiens_hsa012000.92268336
83Arginine and proline metabolism_Homo sapiens_hsa003300.89441158
84Measles_Homo sapiens_hsa051620.88717373
85Ether lipid metabolism_Homo sapiens_hsa005650.86415186
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86118818
87Tyrosine metabolism_Homo sapiens_hsa003500.85125107
88Phenylalanine metabolism_Homo sapiens_hsa003600.84213082
89Biosynthesis of amino acids_Homo sapiens_hsa012300.83585578
90Systemic lupus erythematosus_Homo sapiens_hsa053220.81808421
91Allograft rejection_Homo sapiens_hsa053300.79998290
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77917060
93Olfactory transduction_Homo sapiens_hsa047400.74014788
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72747036
95Amphetamine addiction_Homo sapiens_hsa050310.72361601
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72145355
97Circadian entrainment_Homo sapiens_hsa047130.70483790
98Vitamin digestion and absorption_Homo sapiens_hsa049770.70204833
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69803248
100Malaria_Homo sapiens_hsa051440.68521347
101Insulin secretion_Homo sapiens_hsa049110.68339768
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.67464936
103Staphylococcus aureus infection_Homo sapiens_hsa051500.66089271
104Huntingtons disease_Homo sapiens_hsa050160.65981215
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65301022
106Salivary secretion_Homo sapiens_hsa049700.64968883
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64852356
108Serotonergic synapse_Homo sapiens_hsa047260.64800911
109Rheumatoid arthritis_Homo sapiens_hsa053230.64501634
110Autoimmune thyroid disease_Homo sapiens_hsa053200.63384432
111Pentose phosphate pathway_Homo sapiens_hsa000300.63139133
112Leishmaniasis_Homo sapiens_hsa051400.62813223
113Salmonella infection_Homo sapiens_hsa051320.62661837
114Alzheimers disease_Homo sapiens_hsa050100.62366309
115* mRNA surveillance pathway_Homo sapiens_hsa030150.61905893
116Pertussis_Homo sapiens_hsa051330.61722999
117Cocaine addiction_Homo sapiens_hsa050300.61653092
118Fatty acid biosynthesis_Homo sapiens_hsa000610.60802387
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60477694
120Taste transduction_Homo sapiens_hsa047420.60402898
121Parkinsons disease_Homo sapiens_hsa050120.60219825
122Dopaminergic synapse_Homo sapiens_hsa047280.60091147
123Viral carcinogenesis_Homo sapiens_hsa052030.59513684
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59477735
125Prion diseases_Homo sapiens_hsa050200.57072563
126* Influenza A_Homo sapiens_hsa051640.56596712
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56536069
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55913598
129Phagosome_Homo sapiens_hsa041450.55743474
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53656052
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52970967
132Gastric acid secretion_Homo sapiens_hsa049710.52510061
133Long-term depression_Homo sapiens_hsa047300.52274719
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.51290667
135Oocyte meiosis_Homo sapiens_hsa041140.50824468
136Long-term potentiation_Homo sapiens_hsa047200.50426535
137Starch and sucrose metabolism_Homo sapiens_hsa005000.50010592
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.49920315
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49443722
140Hepatitis B_Homo sapiens_hsa051610.49361239
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49331427
142HTLV-I infection_Homo sapiens_hsa051660.49263468
143N-Glycan biosynthesis_Homo sapiens_hsa005100.49121905
144Glutathione metabolism_Homo sapiens_hsa004800.47299261
145Thyroid cancer_Homo sapiens_hsa052160.46856507
146Metabolic pathways_Homo sapiens_hsa011000.46748552
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46386657
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45984668
149Selenocompound metabolism_Homo sapiens_hsa004500.45574894
150Renin secretion_Homo sapiens_hsa049240.45179238
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44807091
152Folate biosynthesis_Homo sapiens_hsa007900.44737103
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44617608
154ABC transporters_Homo sapiens_hsa020100.44359178
155Apoptosis_Homo sapiens_hsa042100.43283088
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42860494
157Lysosome_Homo sapiens_hsa041420.42262442
158Intestinal immune network for IgA production_Homo sapiens_hsa046720.41238126
159Mineral absorption_Homo sapiens_hsa049780.40915451
160Type I diabetes mellitus_Homo sapiens_hsa049400.39406027
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38380348
162TNF signaling pathway_Homo sapiens_hsa046680.38368993
163Protein export_Homo sapiens_hsa030600.37571783
164African trypanosomiasis_Homo sapiens_hsa051430.37052616
165Platelet activation_Homo sapiens_hsa046110.36502864
166Thyroid hormone synthesis_Homo sapiens_hsa049180.36247336
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35890527
168Drug metabolism - other enzymes_Homo sapiens_hsa009830.34255979
169Glycerolipid metabolism_Homo sapiens_hsa005610.33612576

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