NYAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.01630803
2vocalization behavior (GO:0071625)5.76639105
3synaptic vesicle maturation (GO:0016188)5.69949698
4locomotory exploration behavior (GO:0035641)5.56436740
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54863376
6layer formation in cerebral cortex (GO:0021819)5.51934742
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.50125546
8neuron cell-cell adhesion (GO:0007158)5.28700216
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.27821763
10protein localization to synapse (GO:0035418)5.10462904
11synaptic vesicle exocytosis (GO:0016079)5.04664909
12dendritic spine morphogenesis (GO:0060997)5.02841076
13regulation of glutamate receptor signaling pathway (GO:1900449)5.00104509
14regulation of synaptic vesicle exocytosis (GO:2000300)4.76713069
15exploration behavior (GO:0035640)4.69513813
16glutamate secretion (GO:0014047)4.68768471
17sodium ion export (GO:0071436)4.55625489
18cerebellar granule cell differentiation (GO:0021707)4.53271240
19cell migration in hindbrain (GO:0021535)4.41011994
20neuron recognition (GO:0008038)4.40418623
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.39994425
22proline transport (GO:0015824)4.37322693
23neurotransmitter secretion (GO:0007269)4.34349064
24regulation of synapse structural plasticity (GO:0051823)4.29368837
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.25045137
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13434394
27regulation of neuronal synaptic plasticity (GO:0048168)4.12593096
28regulation of synaptic vesicle transport (GO:1902803)4.11931894
29axonal fasciculation (GO:0007413)4.06838197
30pyrimidine nucleobase catabolic process (GO:0006208)4.01223052
31dendrite morphogenesis (GO:0048813)3.94829125
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.91427050
33glutamate receptor signaling pathway (GO:0007215)3.88447691
34postsynaptic membrane organization (GO:0001941)3.86137699
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83809718
36synaptic transmission, glutamatergic (GO:0035249)3.80467854
37gamma-aminobutyric acid transport (GO:0015812)3.80174907
38potassium ion homeostasis (GO:0055075)3.76608058
39negative regulation of microtubule polymerization (GO:0031115)3.74401126
40L-amino acid import (GO:0043092)3.72805816
41positive regulation of synapse maturation (GO:0090129)3.71260788
42positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69132545
43establishment of mitochondrion localization (GO:0051654)3.68067758
44neurotransmitter-gated ion channel clustering (GO:0072578)3.66342009
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66107426
46neuronal action potential propagation (GO:0019227)3.65548300
47positive regulation of neurotransmitter transport (GO:0051590)3.63827139
48presynaptic membrane organization (GO:0097090)3.62681344
49activation of protein kinase A activity (GO:0034199)3.61417611
50regulation of dendritic spine morphogenesis (GO:0061001)3.58569288
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.58304294
52neuron-neuron synaptic transmission (GO:0007270)3.58282660
53transmission of nerve impulse (GO:0019226)3.56752287
54regulation of synapse maturation (GO:0090128)3.55866066
55auditory behavior (GO:0031223)3.55526843
56positive regulation of membrane potential (GO:0045838)3.55259907
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53602339
58neurotransmitter transport (GO:0006836)3.53490842
59central nervous system projection neuron axonogenesis (GO:0021952)3.49612527
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49039700
61axon ensheathment in central nervous system (GO:0032291)3.48841574
62central nervous system myelination (GO:0022010)3.48841574
63long-term memory (GO:0007616)3.48327805
64nucleobase catabolic process (GO:0046113)3.48093900
65cell communication by electrical coupling (GO:0010644)3.44283878
66regulation of voltage-gated calcium channel activity (GO:1901385)3.42413705
67positive regulation of neurotransmitter secretion (GO:0001956)3.41713654
68neuromuscular process controlling balance (GO:0050885)3.41602008
69amino acid import (GO:0043090)3.41043762
70regulation of ARF protein signal transduction (GO:0032012)3.40243830
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37931749
72regulation of postsynaptic membrane potential (GO:0060078)3.35260597
73negative regulation of dendrite morphogenesis (GO:0050774)3.35028053
74prepulse inhibition (GO:0060134)3.30464002
75potassium ion import (GO:0010107)3.27471750
76regulation of neurotransmitter levels (GO:0001505)3.26019036
77positive regulation of dendritic spine development (GO:0060999)3.24918350
78regulation of vesicle fusion (GO:0031338)3.24469777
79synapse assembly (GO:0007416)3.24149110
80regulation of neurotransmitter secretion (GO:0046928)3.22179036
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20681029
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19093584
83response to auditory stimulus (GO:0010996)3.19025955
84positive regulation of dendritic spine morphogenesis (GO:0061003)3.18032504
85intraspecies interaction between organisms (GO:0051703)3.17393394
86social behavior (GO:0035176)3.17393394
87neuromuscular synaptic transmission (GO:0007274)3.16708154
88dendritic spine organization (GO:0097061)3.15304718
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14957140
90cerebellar Purkinje cell differentiation (GO:0021702)3.14235947
91mating behavior (GO:0007617)3.13301241
92synaptic vesicle endocytosis (GO:0048488)3.13092068
93organelle transport along microtubule (GO:0072384)3.12038748
94regulation of synaptic plasticity (GO:0048167)3.11729980
95positive regulation of synapse assembly (GO:0051965)3.11549285
96dopamine receptor signaling pathway (GO:0007212)3.11427624
97neuronal ion channel clustering (GO:0045161)3.10683639
98regulation of synaptic transmission, glutamatergic (GO:0051966)3.10284097
99cell differentiation in hindbrain (GO:0021533)3.09785043
100regulation of dendritic spine development (GO:0060998)3.09584836
101clathrin coat assembly (GO:0048268)3.08627704
102neuromuscular process (GO:0050905)3.08540541
103innervation (GO:0060384)3.07814315
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07594371
105presynaptic membrane assembly (GO:0097105)3.03946825
106vesicle transport along microtubule (GO:0047496)3.03559091
107cellular potassium ion homeostasis (GO:0030007)3.02895352
108positive regulation of dendrite development (GO:1900006)3.02586232
109regulation of synaptic transmission (GO:0050804)3.02123429
110synapse organization (GO:0050808)3.02105984
111axon extension (GO:0048675)3.01495046
112glycine transport (GO:0015816)3.00456645
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98924670
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.98206886
115cellular sodium ion homeostasis (GO:0006883)2.97322078
116membrane depolarization (GO:0051899)2.97026104
117regulation of dendrite morphogenesis (GO:0048814)2.95996307
118regulation of neurotransmitter transport (GO:0051588)2.95793181
119axon cargo transport (GO:0008088)2.95571769
120membrane hyperpolarization (GO:0060081)2.95537310
121mitochondrion transport along microtubule (GO:0047497)2.95288157
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.95288157
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.94384913
124neuromuscular process controlling posture (GO:0050884)2.93747163
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93629009
126response to histamine (GO:0034776)2.93568411
127learning (GO:0007612)2.93298186
128membrane depolarization during action potential (GO:0086010)2.91821656
129cerebellar Purkinje cell layer development (GO:0021680)2.91108979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.44436749
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22130493
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13905528
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00226607
5GBX2_23144817_ChIP-Seq_PC3_Human2.96969356
6REST_21632747_ChIP-Seq_MESCs_Mouse2.86584807
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.83910451
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83206355
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83206355
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78490105
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.75300123
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59342487
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55674987
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54132455
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52927152
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51971357
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.49720920
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.44125286
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41745256
20DROSHA_22980978_ChIP-Seq_HELA_Human2.41350630
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34037916
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.33799958
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.31087937
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.30656740
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21518090
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18538421
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07782202
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00875187
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95699048
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85598826
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81675941
32AR_21572438_ChIP-Seq_LNCaP_Human1.81522916
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.75902449
34ZNF274_21170338_ChIP-Seq_K562_Hela1.68202142
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57918253
36TAF15_26573619_Chip-Seq_HEK293_Human1.54133419
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.53286259
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51896378
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48242681
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.46856647
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44668090
42SMAD4_21799915_ChIP-Seq_A2780_Human1.38791406
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38404861
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37573579
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.36870370
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33656715
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31897734
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31701800
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30389835
50KDM2B_26808549_Chip-Seq_K562_Human1.30355558
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29629823
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.28247734
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26644296
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25928756
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25494993
56RNF2_27304074_Chip-Seq_NSC_Mouse1.24042364
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21895037
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20138300
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20130651
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.18608430
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17395804
62IGF1R_20145208_ChIP-Seq_DFB_Human1.16854440
63LXR_22292898_ChIP-Seq_THP-1_Human1.16191104
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15843418
65AR_19668381_ChIP-Seq_PC3_Human1.15346219
66P300_19829295_ChIP-Seq_ESCs_Human1.14422379
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14345272
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14002117
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13102765
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11077578
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09885104
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09063886
73AR_25329375_ChIP-Seq_VCAP_Human1.08672547
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.06994421
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06651219
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04302639
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04201204
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04008550
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03907503
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02932214
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02890560
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01420304
83CTCF_27219007_Chip-Seq_Bcells_Human0.99745071
84STAT3_23295773_ChIP-Seq_U87_Human0.99190954
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.97771043
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96845444
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96087136
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95417393
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.92429071
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.92083151
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91951481
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91530089
93AHR_22903824_ChIP-Seq_MCF-7_Human0.91409952
94OCT4_19829295_ChIP-Seq_ESCs_Human0.91308225
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.91211624
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90669273
97PIAS1_25552417_ChIP-Seq_VCAP_Human0.90464690
98TCF4_23295773_ChIP-Seq_U87_Human0.89046108
99RUNX2_22187159_ChIP-Seq_PCA_Human0.88556912
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88450170
101SMC4_20622854_ChIP-Seq_HELA_Human0.88105154
102DPY_21335234_ChIP-Seq_ESCs_Mouse0.87195092
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.87025001
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86862612
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86491241
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86445445
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86445445
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86406920
109KDM2B_26808549_Chip-Seq_DND41_Human0.86006849
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85551957
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85537845
112JUN_21703547_ChIP-Seq_K562_Human0.84616369
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84588675
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.84482328
115CREB1_26743006_Chip-Seq_LNCaP_Human0.84103126
116FUS_26573619_Chip-Seq_HEK293_Human0.83852378
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83663195
118RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83647374
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.83368979
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82754474
121KLF4_19829295_ChIP-Seq_ESCs_Human0.79950218
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79136471
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78987684
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.78685501
125NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78007465
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76886205
127P68_20966046_ChIP-Seq_HELA_Human0.76832730
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75785864
129SMAD4_21741376_ChIP-Seq_ESCs_Human0.75649280
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.74266896
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.74216609
132SOX3_22085726_ChIP-Seq_NPCs_Mouse0.74169499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02578753
2MP0003880_abnormal_central_pattern4.56102373
3MP0003635_abnormal_synaptic_transmissio3.98971289
4MP0004270_analgesia3.82531622
5MP0005423_abnormal_somatic_nervous3.31026502
6MP0002063_abnormal_learning/memory/cond3.24145841
7MP0009745_abnormal_behavioral_response3.17137613
8MP0001968_abnormal_touch/_nociception2.99426823
9MP0002734_abnormal_mechanical_nocicepti2.86687127
10MP0002064_seizures2.86098225
11MP0009046_muscle_twitch2.74802368
12MP0002572_abnormal_emotion/affect_behav2.68225638
13MP0002822_catalepsy2.58070871
14MP0000778_abnormal_nervous_system2.46515844
15MP0002735_abnormal_chemical_nociception2.39699418
16MP0002733_abnormal_thermal_nociception2.34705792
17MP0001486_abnormal_startle_reflex2.32903196
18MP0006276_abnormal_autonomic_nervous2.28846272
19MP0002736_abnormal_nociception_after2.23595270
20MP0002272_abnormal_nervous_system2.23091679
21MP0001440_abnormal_grooming_behavior2.22455856
22MP0002184_abnormal_innervation2.17469107
23MP0004858_abnormal_nervous_system2.14569070
24MP0001970_abnormal_pain_threshold2.09265879
25MP0004811_abnormal_neuron_physiology1.94307503
26MP0001501_abnormal_sleep_pattern1.90234311
27MP0002557_abnormal_social/conspecific_i1.86442732
28MP0002067_abnormal_sensory_capabilities1.86012738
29MP0009780_abnormal_chondrocyte_physiolo1.85097175
30MP0003123_paternal_imprinting1.81703289
31MP0004924_abnormal_behavior1.81561122
32MP0005386_behavior/neurological_phenoty1.81561122
33MP0003329_amyloid_beta_deposits1.80019558
34MP0000955_abnormal_spinal_cord1.79010143
35MP0002909_abnormal_adrenal_gland1.64450731
36MP0003122_maternal_imprinting1.62060813
37MP0008569_lethality_at_weaning1.60030664
38MP0001529_abnormal_vocalization1.58679714
39MP0005645_abnormal_hypothalamus_physiol1.57466744
40MP0002882_abnormal_neuron_morphology1.53940353
41MP0004885_abnormal_endolymph1.46638727
42MP0002066_abnormal_motor_capabilities/c1.43330345
43MP0003787_abnormal_imprinting1.41756684
44MP0000569_abnormal_digit_pigmentation1.38819723
45MP0001905_abnormal_dopamine_level1.36283353
46MP0002152_abnormal_brain_morphology1.32567306
47MP0001984_abnormal_olfaction1.32204313
48MP0003879_abnormal_hair_cell1.28022650
49MP0003690_abnormal_glial_cell1.25822714
50MP0000920_abnormal_myelination1.23163426
51MP0005646_abnormal_pituitary_gland1.18192900
52MP0001502_abnormal_circadian_rhythm1.14164275
53MP0005499_abnormal_olfactory_system1.12425082
54MP0005394_taste/olfaction_phenotype1.12425082
55MP0003283_abnormal_digestive_organ1.10986904
56MP0004142_abnormal_muscle_tone1.10534855
57MP0000751_myopathy1.07875284
58MP0003633_abnormal_nervous_system1.06349755
59MP0001188_hyperpigmentation1.05812749
60MP0000631_abnormal_neuroendocrine_gland1.04625618
61MP0004742_abnormal_vestibular_system0.97702861
62MP0002069_abnormal_eating/drinking_beha0.96792786
63MP0003631_nervous_system_phenotype0.96064372
64MP0003861_abnormal_nervous_system0.94213879
65MP0001348_abnormal_lacrimal_gland0.89397172
66MP0002752_abnormal_somatic_nervous0.88530588
67MP0002638_abnormal_pupillary_reflex0.88231116
68MP0008872_abnormal_physiological_respon0.88043449
69MP0008961_abnormal_basal_metabolism0.87716024
70MP0003634_abnormal_glial_cell0.85193299
71MP0002751_abnormal_autonomic_nervous0.84279357
72MP0002229_neurodegeneration0.83890825
73MP0004085_abnormal_heartbeat0.78153605
74MP0005187_abnormal_penis_morphology0.77942740
75MP0010386_abnormal_urinary_bladder0.76913430
76MP0002102_abnormal_ear_morphology0.74502373
77MP0005623_abnormal_meninges_morphology0.74099886
78MP0001963_abnormal_hearing_physiology0.73597714
79MP0003632_abnormal_nervous_system0.73215920
80MP0005409_darkened_coat_color0.71966638
81MP0001346_abnormal_lacrimal_gland0.71569269
82MP0001299_abnormal_eye_distance/0.71322929
83MP0008874_decreased_physiological_sensi0.70855984
84MP0001177_atelectasis0.70476549
85MP0004133_heterotaxia0.70200084
86MP0004145_abnormal_muscle_electrophysio0.68859712
87MP0003137_abnormal_impulse_conducting0.68728714
88MP0000604_amyloidosis0.68369273
89MP0003121_genomic_imprinting0.67965915
90MP0001485_abnormal_pinna_reflex0.67377292
91MP0005535_abnormal_body_temperature0.66608695
92MP0006072_abnormal_retinal_apoptosis0.66272376
93MP0000013_abnormal_adipose_tissue0.65791033
94MP0000537_abnormal_urethra_morphology0.65689743
95MP0004130_abnormal_muscle_cell0.65657535
96MP0000579_abnormal_nail_morphology0.64948894
97MP0008789_abnormal_olfactory_epithelium0.64891548
98MP0000026_abnormal_inner_ear0.64212551
99MP0001943_abnormal_respiration0.63903492
100MP0002653_abnormal_ependyma_morphology0.62720385
101MP0002090_abnormal_vision0.60759456
102MP0005551_abnormal_eye_electrophysiolog0.60703066
103MP0002837_dystrophic_cardiac_calcinosis0.60307237
104MP0002234_abnormal_pharynx_morphology0.60128586
105MP0010768_mortality/aging0.60102012
106MP0010769_abnormal_survival0.59695346
107MP0002082_postnatal_lethality0.58583443
108MP0010770_preweaning_lethality0.58583443
109MP0002249_abnormal_larynx_morphology0.58456615
110MP0001986_abnormal_taste_sensitivity0.58370283
111MP0003938_abnormal_ear_development0.57874276
112MP0002081_perinatal_lethality0.57735111
113MP0001664_abnormal_digestion0.57106102
114MP0008877_abnormal_DNA_methylation0.56130524
115MP0000534_abnormal_ureter_morphology0.53731893
116MP0003075_altered_response_to0.52920777
117MP0000566_synostosis0.52039895
118MP0004147_increased_porphyrin_level0.49544772

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.50979194
2Focal motor seizures (HP:0011153)5.77518589
3Focal seizures (HP:0007359)5.07117125
4Visual hallucinations (HP:0002367)4.91871132
5Supranuclear gaze palsy (HP:0000605)4.04714989
6Mutism (HP:0002300)3.93608549
7Epileptic encephalopathy (HP:0200134)3.76867276
8Progressive cerebellar ataxia (HP:0002073)3.75978107
9Atonic seizures (HP:0010819)3.69783821
10Ankle clonus (HP:0011448)3.68171702
11Limb dystonia (HP:0002451)3.61773356
12Amblyopia (HP:0000646)3.52114120
13Absence seizures (HP:0002121)3.50268946
14Febrile seizures (HP:0002373)3.38302499
15Annular pancreas (HP:0001734)3.37296063
16Action tremor (HP:0002345)3.33038419
17Amyotrophic lateral sclerosis (HP:0007354)3.30060007
18Generalized tonic-clonic seizures (HP:0002069)3.29637494
19Broad-based gait (HP:0002136)3.26794165
20Dialeptic seizures (HP:0011146)3.13956445
21Abnormality of the corticospinal tract (HP:0002492)3.10356187
22Urinary bladder sphincter dysfunction (HP:0002839)3.10035493
23Termporal pattern (HP:0011008)3.07100202
24Insidious onset (HP:0003587)3.07100202
25Impaired vibration sensation in the lower limbs (HP:0002166)3.06470510
26Papilledema (HP:0001085)3.05768248
27Poor eye contact (HP:0000817)3.02488249
28Excessive salivation (HP:0003781)2.96901674
29Drooling (HP:0002307)2.96901674
30Urinary urgency (HP:0000012)2.93456319
31Cerebral inclusion bodies (HP:0100314)2.89933571
32Depression (HP:0000716)2.86656961
33Abnormal eating behavior (HP:0100738)2.83824096
34Abnormality of the lower motor neuron (HP:0002366)2.80985988
35Neurofibrillary tangles (HP:0002185)2.77973765
36Tetraplegia (HP:0002445)2.75109702
37Impaired social interactions (HP:0000735)2.75077753
38Abnormal social behavior (HP:0012433)2.75077753
39Polyphagia (HP:0002591)2.72991662
40Hemiparesis (HP:0001269)2.72878316
41Progressive inability to walk (HP:0002505)2.67968948
42Sleep apnea (HP:0010535)2.67560233
43Spastic gait (HP:0002064)2.66520409
44Insomnia (HP:0100785)2.65952923
45Genetic anticipation (HP:0003743)2.65779713
46Anxiety (HP:0000739)2.65302600
47Status epilepticus (HP:0002133)2.64250033
48Torticollis (HP:0000473)2.60846857
49Agitation (HP:0000713)2.56547089
50Truncal ataxia (HP:0002078)2.56253987
51Nuclear cataract (HP:0100018)2.52605334
52Megalencephaly (HP:0001355)2.49443571
53Turricephaly (HP:0000262)2.48008820
54Cerebral hypomyelination (HP:0006808)2.44060124
55Diplopia (HP:0000651)2.38652240
56Abnormality of binocular vision (HP:0011514)2.38652240
57Dysdiadochokinesis (HP:0002075)2.37714789
58Akinesia (HP:0002304)2.37243669
59Aplasia of the phalanges of the hand (HP:0009802)2.37241593
60Aplasia involving bones of the extremities (HP:0009825)2.37241593
61Aplasia involving bones of the upper limbs (HP:0009823)2.37241593
62Focal dystonia (HP:0004373)2.36556735
63Dysmetria (HP:0001310)2.35296749
64Apathy (HP:0000741)2.28236676
65Postural instability (HP:0002172)2.27759064
66Gaze-evoked nystagmus (HP:0000640)2.26923485
67EEG with generalized epileptiform discharges (HP:0011198)2.25954326
68Inappropriate behavior (HP:0000719)2.25895250
69Lower limb muscle weakness (HP:0007340)2.24343340
70Epileptiform EEG discharges (HP:0011182)2.24265524
71Stereotypic behavior (HP:0000733)2.24214235
72Spastic tetraparesis (HP:0001285)2.22501120
73Hyperventilation (HP:0002883)2.20159416
74Hypsarrhythmia (HP:0002521)2.20107857
75Pheochromocytoma (HP:0002666)2.19796113
76Morphological abnormality of the pyramidal tract (HP:0002062)2.19705664
77Craniofacial dystonia (HP:0012179)2.17844329
78Fetal akinesia sequence (HP:0001989)2.16681550
79Delusions (HP:0000746)2.15960121
80Pointed chin (HP:0000307)2.14599235
81Hypoplasia of the brainstem (HP:0002365)2.13141951
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.13141951
83Hypoventilation (HP:0002791)2.12295929
84Bradykinesia (HP:0002067)2.12270638
85Zonular cataract (HP:0010920)2.11479191
86Obstructive sleep apnea (HP:0002870)2.10407372
87Impaired smooth pursuit (HP:0007772)2.08054023
88Peripheral hypomyelination (HP:0007182)2.07888052
89Hyperthyroidism (HP:0000836)2.03982989
90Hyperacusis (HP:0010780)2.02864408
91Failure to thrive in infancy (HP:0001531)2.01610955
92Impaired vibratory sensation (HP:0002495)1.99219874
93Diminished motivation (HP:0000745)1.97911703
94Lower limb amyotrophy (HP:0007210)1.96345231
95Inability to walk (HP:0002540)1.95333333
96Lissencephaly (HP:0001339)1.93291638
97Abnormality of salivation (HP:0100755)1.93003703
98Neuronal loss in central nervous system (HP:0002529)1.92282069
99Intention tremor (HP:0002080)1.90215774
100Incomplete penetrance (HP:0003829)1.87407993
101Sporadic (HP:0003745)1.87118863
102Elfin facies (HP:0004428)1.86395615
103Rigidity (HP:0002063)1.85953460
104Bronchomalacia (HP:0002780)1.85493845
105Spinal canal stenosis (HP:0003416)1.85278391
106Ventricular fibrillation (HP:0001663)1.84909370
107Hemiplegia (HP:0002301)1.84486883
108Shoulder girdle muscle weakness (HP:0003547)1.83974665
109Abnormality of ocular smooth pursuit (HP:0000617)1.83185576
110Neuroendocrine neoplasm (HP:0100634)1.82359457
111Sacral dimple (HP:0000960)1.81348942
112Clonus (HP:0002169)1.81258355
113Absent speech (HP:0001344)1.80567222
114Specific learning disability (HP:0001328)1.79812563
115Exotropia (HP:0000577)1.79385958
116Rapidly progressive (HP:0003678)1.78672311
117Degeneration of the lateral corticospinal tracts (HP:0002314)1.77970993
118Lower limb asymmetry (HP:0100559)1.77011021
119Spastic tetraplegia (HP:0002510)1.74278025
120Split foot (HP:0001839)1.74267339
121Hypoplasia of the corpus callosum (HP:0002079)1.71853469
122Overriding aorta (HP:0002623)1.71066005
123Hand muscle atrophy (HP:0009130)1.70140811
124Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69993278
125CNS hypomyelination (HP:0003429)1.68089753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.75701711
2MAP3K93.98770497
3NTRK33.81202800
4EPHA43.12157273
5MAP3K42.96014492
6MINK12.79602384
7NTRK22.55161644
8MAP2K72.27108405
9PAK62.23506723
10DAPK22.13597972
11NTRK11.99469359
12PNCK1.96083297
13MAPK131.95779917
14SIK21.92554612
15LATS21.90970979
16KSR21.84953168
17MAP2K41.69315164
18PHKG21.67738521
19PHKG11.67738521
20KSR11.67158017
21CAMKK11.58876583
22MAP3K121.58562559
23CDK51.55152011
24UHMK11.46526702
25PRKD31.44869044
26GRK51.40173281
27CASK1.39614984
28TNIK1.36255894
29DYRK21.24832978
30TAOK21.24434880
31TYRO31.19944864
32CSNK1G21.16962797
33DAPK11.16409277
34PLK21.14364532
35TAOK11.09657341
36LIMK11.08643678
37PRKCG1.05189840
38ARAF1.01265341
39STK111.00925040
40MAP3K21.00213476
41CDK150.98615682
42CDK180.97746703
43MARK20.97639536
44CDK140.97318697
45STK380.97305270
46RET0.97007978
47PINK10.92404473
48PAK30.91602971
49CDK11A0.87074700
50FES0.86701930
51SGK20.86040461
52RIPK40.84666693
53ALK0.83936597
54CDK190.80701842
55CAMK2A0.79823558
56DYRK1A0.78372501
57NEK60.77747188
58SGK30.75992134
59ERBB30.75850128
60CSNK1G30.75202974
61PRPF4B0.69852262
62RPS6KA20.68650683
63CAMK1G0.68592054
64EPHB20.66302523
65CAMK10.65417080
66WNK10.64306225
67PRKCZ0.64143116
68LMTK20.63679003
69PRKCH0.61496059
70CAMK2B0.58688397
71PKN10.58228637
72CAMKK20.56512283
73CDC42BPA0.56114718
74MAP3K110.55980719
75SGK4940.55947390
76SGK2230.55947390
77SGK10.55433764
78ICK0.55381781
79SCYL20.53810533
80WNK30.53797842
81RAF10.53220831
82MAP3K60.52203491
83CAMK2G0.51688326
84CSNK1A1L0.51158349
85FYN0.49353295
86BRAF0.49336681
87OXSR10.47823125
88PDK10.45805038
89FGR0.45538890
90CAMK1D0.45476922
91RPS6KA30.44950628
92ERBB20.44498777
93PDPK10.43129293
94MAPK120.43037607
95NME10.42007060
96PRKCE0.40778691
97MAPK100.40201840
98CSNK1G10.40076918
99MAP2K10.36334634
100BRSK10.35603372
101MAPK90.34582331
102ADRBK10.34547587
103CAMK40.34545454
104RIPK10.34006261
105DDR20.33687985
106CSNK1E0.33323695
107PRKCB0.33317610
108ROCK10.32893439
109ROCK20.32570879
110WNK40.31634389
111FER0.31290485
112MAPK80.30899758
113MAP2K60.29425643
114EEF2K0.28769917
115CSNK1D0.28230928
116DAPK30.28204401
117FGFR20.28139449
118CAMK2D0.27937633
119GSK3B0.27916553
120BCR0.26168969
121PRKCA0.25082342

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.55640340
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18376950
3GABAergic synapse_Homo sapiens_hsa047272.60728405
4Olfactory transduction_Homo sapiens_hsa047402.59216340
5Circadian entrainment_Homo sapiens_hsa047132.51548447
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49623904
7Long-term potentiation_Homo sapiens_hsa047202.44677074
8Glutamatergic synapse_Homo sapiens_hsa047242.42883797
9Morphine addiction_Homo sapiens_hsa050322.31922021
10Amphetamine addiction_Homo sapiens_hsa050312.27977624
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26956822
12Dopaminergic synapse_Homo sapiens_hsa047282.25610017
13Cholinergic synapse_Homo sapiens_hsa047251.98602590
14Salivary secretion_Homo sapiens_hsa049701.93005575
15Cocaine addiction_Homo sapiens_hsa050301.85173499
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82389359
17Insulin secretion_Homo sapiens_hsa049111.78831840
18Gastric acid secretion_Homo sapiens_hsa049711.76181800
19Long-term depression_Homo sapiens_hsa047301.71221727
20Serotonergic synapse_Homo sapiens_hsa047261.70578038
21Axon guidance_Homo sapiens_hsa043601.70310052
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68902392
23Taste transduction_Homo sapiens_hsa047421.68467403
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68403606
25Renin secretion_Homo sapiens_hsa049241.66949615
26Oxytocin signaling pathway_Homo sapiens_hsa049211.60711349
27Gap junction_Homo sapiens_hsa045401.58219809
28GnRH signaling pathway_Homo sapiens_hsa049121.50009018
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35962291
30Calcium signaling pathway_Homo sapiens_hsa040201.34288483
31Estrogen signaling pathway_Homo sapiens_hsa049151.33959851
32Glioma_Homo sapiens_hsa052141.26168835
33Collecting duct acid secretion_Homo sapiens_hsa049661.25026758
34Vitamin B6 metabolism_Homo sapiens_hsa007501.24012348
35ErbB signaling pathway_Homo sapiens_hsa040121.22964504
36Melanogenesis_Homo sapiens_hsa049161.20692948
37Type II diabetes mellitus_Homo sapiens_hsa049301.20144353
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16975279
39Cardiac muscle contraction_Homo sapiens_hsa042601.13988353
40cAMP signaling pathway_Homo sapiens_hsa040241.10203061
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10164253
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99577686
43Oocyte meiosis_Homo sapiens_hsa041140.98699044
44Dorso-ventral axis formation_Homo sapiens_hsa043200.96903891
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93158146
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90925621
47Endometrial cancer_Homo sapiens_hsa052130.88154449
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.87054960
49Vibrio cholerae infection_Homo sapiens_hsa051100.83731361
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.82568318
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.81400626
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80522942
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79997001
54Phototransduction_Homo sapiens_hsa047440.76681056
55VEGF signaling pathway_Homo sapiens_hsa043700.76384841
56MAPK signaling pathway_Homo sapiens_hsa040100.75437267
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75283851
58Choline metabolism in cancer_Homo sapiens_hsa052310.74997769
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74909299
60Renal cell carcinoma_Homo sapiens_hsa052110.74585812
61Alcoholism_Homo sapiens_hsa050340.73789217
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72546897
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72462070
64Colorectal cancer_Homo sapiens_hsa052100.71551733
65Dilated cardiomyopathy_Homo sapiens_hsa054140.70430842
66mTOR signaling pathway_Homo sapiens_hsa041500.69453171
67Thyroid hormone synthesis_Homo sapiens_hsa049180.68335765
68Alzheimers disease_Homo sapiens_hsa050100.65722750
69Wnt signaling pathway_Homo sapiens_hsa043100.65099711
70Pancreatic secretion_Homo sapiens_hsa049720.63792688
71Ras signaling pathway_Homo sapiens_hsa040140.63326237
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62742858
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62725646
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.59803020
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59394352
76Inositol phosphate metabolism_Homo sapiens_hsa005620.58848582
77Insulin signaling pathway_Homo sapiens_hsa049100.58727270
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58043313
79Rap1 signaling pathway_Homo sapiens_hsa040150.57856055
80Non-small cell lung cancer_Homo sapiens_hsa052230.56813770
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56714334
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55625142
83Prion diseases_Homo sapiens_hsa050200.54807277
84Glucagon signaling pathway_Homo sapiens_hsa049220.53512518
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52337730
86Endocytosis_Homo sapiens_hsa041440.51687322
87Parkinsons disease_Homo sapiens_hsa050120.50087429
88Hedgehog signaling pathway_Homo sapiens_hsa043400.49856947
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47151095
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45864131
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45613989
92Oxidative phosphorylation_Homo sapiens_hsa001900.42350145
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41660571
94Tight junction_Homo sapiens_hsa045300.40545308
95AMPK signaling pathway_Homo sapiens_hsa041520.38853165
96Type I diabetes mellitus_Homo sapiens_hsa049400.38286782
97Circadian rhythm_Homo sapiens_hsa047100.37948558
98Prolactin signaling pathway_Homo sapiens_hsa049170.36872403
99Bile secretion_Homo sapiens_hsa049760.36482626
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35205525
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35197160
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.34115398
103Hippo signaling pathway_Homo sapiens_hsa043900.33155053
104Huntingtons disease_Homo sapiens_hsa050160.32510365
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31929169
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30321921
107Ovarian steroidogenesis_Homo sapiens_hsa049130.29729861
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29141068
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27770600
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23205633

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