ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K9 demethylation (GO:0033169)	7.07234077
2	regulation of female gonad development (GO:2000194)	6.45822161
3	myelination in peripheral nervous system (GO:0022011)	6.37934177
4	peripheral nervous system axon ensheathment (GO:0032292)	6.37934177
5	retinal cone cell development (GO:0046549)	5.93227327
6	positive regulation of p38MAPK cascade (GO:1900745)	5.73821541
7	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	5.40023885
8	neurotransmitter catabolic process (GO:0042135)	4.64960960
9	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	4.60966560
10	regulation of p38MAPK cascade (GO:1900744)	4.52162384
11	post-embryonic morphogenesis (GO:0009886)	4.49939115
12	chemosensory behavior (GO:0007635)	4.17580086
13	cellular glucuronidation (GO:0052695)	4.14256127
14	melanin biosynthetic process (GO:0042438)	4.12147086
15	positive regulation of glomerulus development (GO:0090193)	4.08526412
16	xenobiotic catabolic process (GO:0042178)	4.08025553
17	coronary vasculature morphogenesis (GO:0060977)	4.06478596
18	glycine transport (GO:0015816)	4.06256993
19	cellular hyperosmotic response (GO:0071474)	4.03619903
20	endothelial cell chemotaxis (GO:0035767)	4.02571125
21	basic amino acid transport (GO:0015802)	4.01126729
22	cell volume homeostasis (GO:0006884)	3.97700485
23	pattern specification involved in kidney development (GO:0061004)	3.93930301
24	piRNA metabolic process (GO:0034587)	3.90315852
25	neuron maturation (GO:0042551)	3.89225344
26	nephron tubule formation (GO:0072079)	3.85143026
27	positive regulation of protein kinase C signaling (GO:0090037)	3.82315147
28	positive regulation of cell cycle checkpoint (GO:1901978)	3.82139949
29	positive regulation of vascular permeability (GO:0043117)	3.78192173
30	uronic acid metabolic process (GO:0006063)	3.73160771
31	glucuronate metabolic process (GO:0019585)	3.73160771
32	melanin metabolic process (GO:0006582)	3.69502205
33	regulation of cell maturation (GO:1903429)	3.69359715
34	metanephric tubule development (GO:0072170)	3.69110812
35	metanephric nephron tubule development (GO:0072234)	3.69110812
36	regulation of DNA methylation (GO:0044030)	3.68758478
37	lysine metabolic process (GO:0006553)	3.66964215
38	lysine catabolic process (GO:0006554)	3.66964215
39	negative regulation of metanephros development (GO:0072217)	3.66848388
40	secondary metabolite biosynthetic process (GO:0044550)	3.65359624
41	organic cation transport (GO:0015695)	3.62535146
42	positive regulation of cellular amine metabolic process (GO:0033240)	3.59799049
43	cranial nerve structural organization (GO:0021604)	3.54933041
44	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	3.54131133
45	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	3.52788684
46	multicellular organism reproduction (GO:0032504)	3.52101809
47	cochlea development (GO:0090102)	3.48653414
48	glutathione biosynthetic process (GO:0006750)	3.44540094
49	metanephric mesenchyme development (GO:0072075)	3.44337580
50	metanephric nephron epithelium development (GO:0072243)	3.40707291
51	cell differentiation involved in metanephros development (GO:0072202)	3.38424954
52	cAMP catabolic process (GO:0006198)	3.36696406
53	nonribosomal peptide biosynthetic process (GO:0019184)	3.33802821
54	surfactant homeostasis (GO:0043129)	3.32520263
55	eye photoreceptor cell development (GO:0042462)	3.28382244
56	cyclic nucleotide catabolic process (GO:0009214)	3.26598155
57	regulation of uterine smooth muscle contraction (GO:0070472)	3.26073908
58	regulation of endothelial cell chemotaxis (GO:2001026)	3.20266874
59	glutathione derivative metabolic process (GO:1901685)	3.18883128
60	glutathione derivative biosynthetic process (GO:1901687)	3.18883128
61	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.16476863
62	photoreceptor cell development (GO:0042461)	3.12653086
63	histone lysine demethylation (GO:0070076)	3.10833637
64	sulfation (GO:0051923)	3.09877210
65	kidney mesenchyme development (GO:0072074)	3.09795482
66	mesonephros development (GO:0001823)	3.08324053
67	positive regulation of CREB transcription factor activity (GO:0032793)	3.07685028
68	positive regulation of microtubule polymerization (GO:0031116)	3.07015898
69	metanephric epithelium development (GO:0072207)	3.05855967
70	meiotic cell cycle (GO:0051321)	3.05394977
71	positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)	3.05024340
72	amino-acid betaine metabolic process (GO:0006577)	3.01879095
73	chemical homeostasis within a tissue (GO:0048875)	2.99484802
74	histone demethylation (GO:0016577)	2.98583895
75	vascular endothelial growth factor signaling pathway (GO:0038084)	2.98568323
76	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.98336781
77	relaxation of smooth muscle (GO:0044557)	2.97949594
78	peptide biosynthetic process (GO:0043043)	2.94303029
79	regulation of acrosome reaction (GO:0060046)	2.93862528
80	brain morphogenesis (GO:0048854)	2.92611471
81	activation of JUN kinase activity (GO:0007257)	2.91715299
82	DNA methylation involved in gamete generation (GO:0043046)	2.89190352
83	myelin maintenance (GO:0043217)	2.88841498
84	auditory receptor cell stereocilium organization (GO:0060088)	2.88710432
85	drug transmembrane transport (GO:0006855)	2.87676679
86	icosanoid secretion (GO:0032309)	2.84970308
87	arachidonic acid secretion (GO:0050482)	2.84970308
88	aspartate family amino acid catabolic process (GO:0009068)	2.83413069
89	nephron tubule development (GO:0072080)	2.83171403
90	cAMP metabolic process (GO:0046058)	2.79237121
91	neuropeptide signaling pathway (GO:0007218)	2.74376346
92	regulation of vasculogenesis (GO:2001212)	2.72108502
93	regulation of macrophage chemotaxis (GO:0010758)	2.70785339
94	regulation of steroid hormone secretion (GO:2000831)	2.70278226
95	embryonic digestive tract development (GO:0048566)	2.60094529
96	nitric oxide biosynthetic process (GO:0006809)	2.59677647
97	cAMP biosynthetic process (GO:0006171)	2.59651788
98	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.59646839
99	gamma-aminobutyric acid transport (GO:0015812)	17.3300313
100	glial cell proliferation (GO:0014009)	10.5579156

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.67233793
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.48136425
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.37478296
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.99255142
5	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.89228442
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.86103714
7	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.55599110
8	DROSHA_22980978_ChIP-Seq_HELA_Human	2.40693078
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.26955872
10	EGR1_19032775_ChIP-ChIP_M12_Human	2.04761925
11	AR_21572438_ChIP-Seq_LNCaP_Human	1.90225535
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.87990214
13	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.87031979
14	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.86285438
15	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.81163491
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59391848
17	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.57907437
18	RXR_22108803_ChIP-Seq_LS180_Human	1.56511509
19	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.54514372
20	CBP_21632823_ChIP-Seq_H3396_Human	1.53438497
21	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.51554470
22	P300_19829295_ChIP-Seq_ESCs_Human	1.50622554
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47609333
24	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.45512716
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.45448160
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.45041430
27	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.44809612
28	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.44740287
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.44541485
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.44453558
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.44290221
32	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.43534719
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39317251
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38331287
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.36609713
36	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.36024655
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35555145
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.34593786
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33299288
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33299288
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32571466
42	VDR_22108803_ChIP-Seq_LS180_Human	1.32569566
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.32321010
44	AR_25329375_ChIP-Seq_VCAP_Human	1.32290932
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31690473
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29904598
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.29895648
48	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.29832083
49	VDR_24787735_ChIP-Seq_THP-1_Human	1.29225711
50	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.29068497
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27396924
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27348392
53	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.27157380
54	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.27157380
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26227594
56	ERG_20517297_ChIP-Seq_VCAP_Human	1.25647865
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24466702
58	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.23959509
59	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.22600039
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22229998
61	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19816903
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19634682
63	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.17731986
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17239743
65	STAT3_23295773_ChIP-Seq_U87_Human	1.15685679
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.15613969
67	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14931389
68	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.14257661
69	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.13631651
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.12880425
71	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12642672
72	SMRT_27268052_Chip-Seq_Bcells_Human	1.11788545
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10786441
74	AR_20517297_ChIP-Seq_VCAP_Human	1.08566078
75	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.08439175
76	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.07466172
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06945209
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06945209
79	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06273929
80	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.05760920
81	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04898048
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04614267
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04291828
84	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.04212099
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03817040
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03437649
87	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.02807384
88	EWS_26573619_Chip-Seq_HEK293_Human	1.02676958
89	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.01663624
90	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01558014
91	SOX2_21211035_ChIP-Seq_LN229_Human	1.01513530
92	TCF4_23295773_ChIP-Seq_U87_Human	1.01029525
93	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.00140608
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99640653
95	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.98835051
96	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98340921
97	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.97654484
98	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94684553
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94456009
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.93451497

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003879_abnormal_hair_cell	4.57443198
2	MP0005377_hearing/vestibular/ear_phenot	4.14723021
3	MP0003878_abnormal_ear_physiology	4.14723021
4	MP0003136_yellow_coat_color	4.14675989
5	MP0002735_abnormal_chemical_nociception	3.47192865
6	MP0003718_maternal_effect	3.19341492
7	MP0001501_abnormal_sleep_pattern	3.03584522
8	MP0003183_abnormal_peptide_metabolism	2.85951006
9	MP0002822_catalepsy	2.85029444
10	MP0000372_irregular_coat_pigmentation	2.84243072
11	MP0002638_abnormal_pupillary_reflex	2.81830060
12	MP0005360_urolithiasis	2.25713827
13	MP0005171_absent_coat_pigmentation	2.03582326
14	MP0008875_abnormal_xenobiotic_pharmacok	2.03089721
15	MP0001485_abnormal_pinna_reflex	1.99001493
16	MP0005257_abnormal_intraocular_pressure	1.93113466
17	MP0001324_abnormal_eye_pigmentation	1.92638361
18	MP0008569_lethality_at_weaning	1.92412239
19	MP0003690_abnormal_glial_cell	1.90714934
20	MP0004147_increased_porphyrin_level	1.89851671
21	MP0002272_abnormal_nervous_system	1.86397269
22	MP0005187_abnormal_penis_morphology	1.85568049
23	MP0002095_abnormal_skin_pigmentation	1.84985299
24	MP0002557_abnormal_social/conspecific_i	1.83513144
25	MP0003632_abnormal_nervous_system	1.83494693
26	MP0003315_abnormal_perineum_morphology	1.83278420
27	MP0002138_abnormal_hepatobiliary_system	1.83268113
28	MP0001348_abnormal_lacrimal_gland	1.82452859
29	MP0002736_abnormal_nociception_after	1.79271198
30	MP0000013_abnormal_adipose_tissue	1.73706312
31	MP0000015_abnormal_ear_pigmentation	1.69592805
32	MP0005551_abnormal_eye_electrophysiolog	1.66506052
33	MP0005332_abnormal_amino_acid	1.65618196
34	MP0002160_abnormal_reproductive_system	1.59434979
35	MP0005058_abnormal_lysosome_morphology	1.57519605
36	MP0003252_abnormal_bile_duct	1.56751289
37	MP0001963_abnormal_hearing_physiology	1.44404117
38	MP0005174_abnormal_tail_pigmentation	1.42825358
39	MP0001968_abnormal_touch/_nociception	1.36800315
40	MP0002229_neurodegeneration	1.35996232
41	MP0005408_hypopigmentation	1.34560421
42	MP0003329_amyloid_beta_deposits	1.29965625
43	MP0003959_abnormal_lean_body	1.28913017
44	MP0008789_abnormal_olfactory_epithelium	1.27168435
45	MP0000427_abnormal_hair_cycle	1.27101103
46	MP0005253_abnormal_eye_physiology	1.26708865
47	MP0002067_abnormal_sensory_capabilities	1.23523058
48	MP0000920_abnormal_myelination	1.21777968
49	MP0000647_abnormal_sebaceous_gland	1.21538839
50	MP0006072_abnormal_retinal_apoptosis	1.17546461
51	MP0009745_abnormal_behavioral_response	1.16340412
52	MP0002653_abnormal_ependyma_morphology	1.12406251
53	MP0009384_cardiac_valve_regurgitation	1.12096394
54	MP0004019_abnormal_vitamin_homeostasis	1.11721367
55	MP0000026_abnormal_inner_ear	1.10008439
56	MP0005394_taste/olfaction_phenotype	1.09236540
57	MP0005499_abnormal_olfactory_system	1.09236540
58	MP0008877_abnormal_DNA_methylation	1.06865190
59	MP0002909_abnormal_adrenal_gland	1.05804611
60	MP0002210_abnormal_sex_determination	1.04916475
61	MP0001879_abnormal_lymphatic_vessel	1.04522668
62	MP0001929_abnormal_gametogenesis	1.04224757
63	MP0001502_abnormal_circadian_rhythm	1.01460104
64	MP0001486_abnormal_startle_reflex	1.00137954
65	MP0009046_muscle_twitch	0.99756180
66	MP0003950_abnormal_plasma_membrane	0.98948608
67	MP0000383_abnormal_hair_follicle	0.98549079
68	MP0002572_abnormal_emotion/affect_behav	0.97445327
69	MP0005395_other_phenotype	0.96628502
70	MP0005266_abnormal_metabolism	0.96254063
71	MP0005410_abnormal_fertilization	0.95931103
72	MP0001664_abnormal_digestion	0.94289149
73	MP0003638_abnormal_response/metabolism_	0.94160700
74	MP0000678_abnormal_parathyroid_gland	0.93725146
75	MP0003890_abnormal_embryonic-extraembry	0.87746732
76	MP0010678_abnormal_skin_adnexa	0.86948645
77	MP0003699_abnormal_female_reproductive	0.86795430
78	MP0003011_delayed_dark_adaptation	0.85946953
79	MP0010386_abnormal_urinary_bladder	0.85663765
80	MP0002089_abnormal_postnatal_growth/wei	0.84087396
81	MP0004742_abnormal_vestibular_system	0.83962011
82	MP0003698_abnormal_male_reproductive	0.82240849
83	MP0003634_abnormal_glial_cell	0.81490119
84	MP0004085_abnormal_heartbeat	0.80840542
85	MP0002928_abnormal_bile_duct	0.80134734
86	MP0002269_muscular_atrophy	0.79419862
87	MP0002733_abnormal_thermal_nociception	0.79139313
88	MP0008872_abnormal_physiological_respon	0.77751455
89	MP0005389_reproductive_system_phenotype	0.77672380
90	MP0003631_nervous_system_phenotype	0.75565189
91	MP0001919_abnormal_reproductive_system	0.74761147
92	MP0002752_abnormal_somatic_nervous	0.74582910
93	MP0005075_abnormal_melanosome_morpholog	0.74073781
94	MP0001756_abnormal_urination	0.73902588
95	MP0001851_eye_inflammation	0.73781001
96	MP0002161_abnormal_fertility/fecundity	0.73096102
97	MP0005195_abnormal_posterior_eye	0.72821710
98	MP0002876_abnormal_thyroid_physiology	0.71681800
99	MP0000569_abnormal_digit_pigmentation	0.71262545
100	MP0002102_abnormal_ear_morphology	0.69760080

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nuclear cataract (HP:0100018)	9.11592212
2	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	6.33346665
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.17699788
4	Congenital stationary night blindness (HP:0007642)	5.06103160
5	Abnormal gallbladder physiology (HP:0012438)	4.64723602
6	Cholecystitis (HP:0001082)	4.64723602
7	Polar cataract (HP:0010696)	4.63145561
8	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.60475492
9	Chromsome breakage (HP:0040012)	4.48725765
10	Increased cerebral lipofuscin (HP:0011813)	4.22614453
11	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.91323913
12	Hypoplasia of the fovea (HP:0007750)	3.91323913
13	Zonular cataract (HP:0010920)	3.85267592
14	Spastic paraparesis (HP:0002313)	3.78344954
15	Neurofibrillary tangles (HP:0002185)	3.64375277
16	Abnormal biliary tract physiology (HP:0012439)	3.63360694
17	Bile duct proliferation (HP:0001408)	3.63360694
18	Abnormality of macular pigmentation (HP:0008002)	3.53522161
19	Bilateral sensorineural hearing impairment (HP:0008619)	3.50688257
20	Aplasia/Hypoplasia of the macula (HP:0008059)	3.42384911
21	Congenital sensorineural hearing impairment (HP:0008527)	3.40744467
22	Osteomalacia (HP:0002749)	3.26370883
23	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.22066717
24	Abolished electroretinogram (ERG) (HP:0000550)	3.21580946
25	Facial shape deformation (HP:0011334)	3.20902662
26	Potter facies (HP:0002009)	3.20902662
27	Abnormality of the fovea (HP:0000493)	3.18240366
28	Aplastic anemia (HP:0001915)	3.01039865
29	Reticulocytopenia (HP:0001896)	2.98720539
30	Diplopia (HP:0000651)	2.96851169
31	Abnormality of binocular vision (HP:0011514)	2.96851169
32	Chorioretinal atrophy (HP:0000533)	2.96036992
33	Bicornuate uterus (HP:0000813)	2.83597334
34	Myokymia (HP:0002411)	2.81943275
35	Posterior subcapsular cataract (HP:0007787)	2.79606867
36	Retinal atrophy (HP:0001105)	2.78175981
37	Abnormal auditory evoked potentials (HP:0006958)	2.73624761
38	Hypercortisolism (HP:0001578)	2.70141655
39	Hypophosphatemic rickets (HP:0004912)	2.67707427
40	Focal segmental glomerulosclerosis (HP:0000097)	2.61939744
41	Hemiparesis (HP:0001269)	2.58482055
42	Supernumerary spleens (HP:0009799)	2.54090812
43	Vacuolated lymphocytes (HP:0001922)	2.53130791
44	Abnormality of midbrain morphology (HP:0002418)	2.52121658
45	Molar tooth sign on MRI (HP:0002419)	2.52121658
46	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.45748836
47	Hyperglycinuria (HP:0003108)	2.42983667
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.36354124
49	Abnormality of the renal collecting system (HP:0004742)	2.34961950
50	Duplicated collecting system (HP:0000081)	2.34387450
51	Subcapsular cataract (HP:0000523)	2.33224692
52	Confusion (HP:0001289)	2.30785811
53	Cerebral inclusion bodies (HP:0100314)	2.25718856
54	Azoospermia (HP:0000027)	2.24569219
55	Macular degeneration (HP:0000608)	2.21110842
56	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.21024708
57	Global brain atrophy (HP:0002283)	2.15555327
58	Renal dysplasia (HP:0000110)	2.13296671
59	Abnormality of proline metabolism (HP:0010907)	2.09474837
60	Hydroxyprolinuria (HP:0003080)	2.09474837
61	White forelock (HP:0002211)	2.06223297
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.04542965
63	Optic nerve coloboma (HP:0000588)	2.03964833
64	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.02670121
65	Patchy hypopigmentation of hair (HP:0011365)	2.01410873
66	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.00522577
67	Short tibia (HP:0005736)	1.97973604
68	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.97769168
69	Axonal loss (HP:0003447)	1.97673734
70	Pili torti (HP:0003777)	1.96130500
71	Anterior segment dysgenesis (HP:0007700)	1.95321994
72	Clubbing of toes (HP:0100760)	1.95088899
73	Paraparesis (HP:0002385)	1.94865305
74	Attenuation of retinal blood vessels (HP:0007843)	1.94133530
75	Impulsivity (HP:0100710)	1.90802050
76	Blue irides (HP:0000635)	1.89455097
77	Bifid tongue (HP:0010297)	1.88283820
78	Hypoplasia of the iris (HP:0007676)	1.88117252
79	Adrenal overactivity (HP:0002717)	1.87132429
80	Impaired smooth pursuit (HP:0007772)	1.81362107
81	Abnormality of the anterior chamber (HP:0000593)	1.78143263
82	Glomerulosclerosis (HP:0000096)	1.75662020
83	Lip pit (HP:0100267)	1.75351615
84	Tachypnea (HP:0002789)	1.74511382
85	Ketosis (HP:0001946)	1.74066913
86	Meckel diverticulum (HP:0002245)	1.72841379
87	Anosmia (HP:0000458)	1.72557337
88	Genital tract atresia (HP:0001827)	1.72504451
89	Progressive visual loss (HP:0000529)	1.71917472
90	Abnormality of the preputium (HP:0100587)	1.71303684
91	Enlarged kidneys (HP:0000105)	1.69402103
92	Decreased circulating renin level (HP:0003351)	1.69391275
93	Albinism (HP:0001022)	1.65964638
94	Segmental peripheral demyelination/remyelination (HP:0003481)	1.65387035
95	Abnormality of chromosome stability (HP:0003220)	1.63558554
96	Truncal obesity (HP:0001956)	1.62124605
97	Abnormality of the ileum (HP:0001549)	1.60620317
98	Conjunctival telangiectasia (HP:0000524)	1.60030591
99	Abnormal spermatogenesis (HP:0008669)	1.59210659
100	Ocular albinism (HP:0001107)	1.58542168

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K6	5.83084864
2	GRK1	5.77426808
3	ARAF	3.08378974
4	ADRBK2	2.83609988
5	MAP3K9	2.83324831
6	MAP3K13	2.83100015
7	NTRK3	2.81279526
8	INSRR	2.43382134
9	NEK6	2.10683850
10	FRK	1.95719114
11	MAPKAPK3	1.94396651
12	STK38	1.89962799
13	MAPK15	1.77434309
14	BCKDK	1.76723266
15	KDR	1.71648800
16	LATS1	1.68905586
17	BMPR1B	1.67453858
18	STK38L	1.64809658
19	STK24	1.56556772
20	KSR2	1.51465982
21	PINK1	1.45970218
22	NME1	1.29842481
23	KIT	1.27433296
24	ADRBK1	1.26956856
25	MET	1.24579387
26	WEE1	1.20110377
27	MAP2K1	1.16738785
28	TAOK3	1.14366213
29	PRKD3	1.13913653
30	CDK3	1.12537899
31	PRKCI	1.12162187
32	DYRK1A	1.11454578
33	MST4	1.09658117
34	EPHA2	1.02032613
35	BRAF	1.01369230
36	SGK494	1.01282285
37	SGK223	1.01282285
38	PDK2	1.00961248
39	ACVR1B	1.00811784
40	STK3	0.98412448
41	MAPK12	0.90362287
42	AURKA	0.88003695
43	TGFBR1	0.87789045
44	PTK2B	0.83272498
45	NEK9	0.82610201
46	CDK9	0.82383870
47	RAF1	0.81652014
48	ERN1	0.79715107
49	PRKCH	0.79457287
50	TRIB3	0.78488935
51	IRAK1	0.75416038
52	SIK1	0.75346039
53	VRK1	0.75193241
54	MAP3K1	0.73969350
55	GSK3A	0.71786455
56	MAPK13	0.69974834
57	PHKG1	0.69806289
58	PHKG2	0.69806289
59	NEK2	0.69099078
60	TIE1	0.68967084
61	PRKAA2	0.68071280
62	MAP3K4	0.67545517
63	CCNB1	0.65213645
64	PRKCG	0.63734869
65	SIK2	0.63020975
66	MAP3K7	0.61558030
67	CAMKK1	0.61374617
68	PRKACA	0.61062685
69	MOS	0.60329419
70	CDK7	0.60087541
71	DDR2	0.59744291
72	IRAK2	0.59217070
73	CDK12	0.58721069
74	PRKD2	0.57696668
75	CSF1R	0.55573128
76	LRRK2	0.54501793
77	NTRK2	0.51562298
78	CHUK	0.51220503
79	GRK6	0.49888009
80	FLT3	0.48805489
81	NUAK1	0.47816366
82	TBK1	0.47702554
83	FER	0.46945485
84	MARK3	0.46103780
85	PLK2	0.44351557
86	PDPK1	0.43895958
87	STK39	0.43602273
88	TNK2	0.43321513
89	PRKCE	0.43035695
90	PRKCZ	0.41048953
91	MKNK2	0.41040059
92	PKN1	0.40292548
93	MAP4K2	0.38092340
94	AKT2	0.37877079
95	RPS6KB2	0.37141301
96	EEF2K	0.36746990
97	CSNK1D	0.33837008
98	PDK1	0.33033109
99	PRKACB	0.32927068
100	FGFR3	0.32914034

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	4.11051024
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	4.03622724
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.86320000
4	Arginine and proline metabolism_Homo sapiens_hsa00330	2.91607347
5	Butanoate metabolism_Homo sapiens_hsa00650	2.66985679
6	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.62979071
7	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.36992084
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.20374649
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15986025
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.10476760
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.99639110
12	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.88845151
13	Arginine biosynthesis_Homo sapiens_hsa00220	1.85071562
14	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.83894558
15	GABAergic synapse_Homo sapiens_hsa04727	1.82410011
16	beta-Alanine metabolism_Homo sapiens_hsa00410	1.80787380
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.73993328
18	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.73755683
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.69556558
20	Phototransduction_Homo sapiens_hsa04744	1.66490183
21	Bile secretion_Homo sapiens_hsa04976	1.57582593
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.56431442
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38440968
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34755937
25	Lysine degradation_Homo sapiens_hsa00310	1.24243796
26	Olfactory transduction_Homo sapiens_hsa04740	1.23229407
27	Retinol metabolism_Homo sapiens_hsa00830	1.21036924
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19785239
29	Morphine addiction_Homo sapiens_hsa05032	1.18025303
30	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.16577426
31	ABC transporters_Homo sapiens_hsa02010	1.13696256
32	Basal transcription factors_Homo sapiens_hsa03022	1.13015231
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12887498
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10793880
35	Small cell lung cancer_Homo sapiens_hsa05222	1.09318610
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08199193
37	Circadian rhythm_Homo sapiens_hsa04710	1.07581353
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04223892
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.02041181
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.01124019
41	Other glycan degradation_Homo sapiens_hsa00511	0.98958181
42	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.94200078
43	Fatty acid degradation_Homo sapiens_hsa00071	0.93537058
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91743599
45	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.91620249
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90885549
47	Glutathione metabolism_Homo sapiens_hsa00480	0.89791256
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.87641410
49	Taste transduction_Homo sapiens_hsa04742	0.86817396
50	Oxidative phosphorylation_Homo sapiens_hsa00190	0.84543508
51	One carbon pool by folate_Homo sapiens_hsa00670	0.84535714
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.83985481
53	Serotonergic synapse_Homo sapiens_hsa04726	0.83369124
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.83249037
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82698474
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.81821207
57	Parkinsons disease_Homo sapiens_hsa05012	0.80171440
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.76986451
59	Protein digestion and absorption_Homo sapiens_hsa04974	0.73789787
60	Phenylalanine metabolism_Homo sapiens_hsa00360	0.73398555
61	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.73349333
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71869625
63	Fatty acid elongation_Homo sapiens_hsa00062	0.71057875
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.68717609
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.67229300
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67148625
67	Propanoate metabolism_Homo sapiens_hsa00640	0.63534341
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.53782983
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.53326096
70	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.51983741
71	Pentose phosphate pathway_Homo sapiens_hsa00030	0.51615553
72	Salivary secretion_Homo sapiens_hsa04970	0.51573852
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51345219
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.49385783
75	Circadian entrainment_Homo sapiens_hsa04713	0.48115217
76	Huntingtons disease_Homo sapiens_hsa05016	0.47915011
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47729593
78	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.47309429
79	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.45763630
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45213676
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.45203285
82	Alzheimers disease_Homo sapiens_hsa05010	0.44980876
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.44772443
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44610351
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44434273
86	Metabolic pathways_Homo sapiens_hsa01100	0.44144713
87	Galactose metabolism_Homo sapiens_hsa00052	0.44018562
88	RNA degradation_Homo sapiens_hsa03018	0.43138933
89	Caffeine metabolism_Homo sapiens_hsa00232	0.42483957
90	Insulin secretion_Homo sapiens_hsa04911	0.40469737
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.39960439
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39001416
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.38210607
94	Cell cycle_Homo sapiens_hsa04110	0.37519101
95	Pancreatic secretion_Homo sapiens_hsa04972	0.36753762
96	Renin-angiotensin system_Homo sapiens_hsa04614	0.36328321
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36171599
98	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35994975
99	Melanoma_Homo sapiens_hsa05218	0.33742774
100	mTOR signaling pathway_Homo sapiens_hsa04150	0.32095265

OACYLP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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