OACYLP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K9 demethylation (GO:0033169)7.07234077
2regulation of female gonad development (GO:2000194)6.45822161
3peripheral nervous system axon ensheathment (GO:0032292)6.37934177
4myelination in peripheral nervous system (GO:0022011)6.37934177
5retinal cone cell development (GO:0046549)5.93227327
6positive regulation of p38MAPK cascade (GO:1900745)5.73821541
7mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.40023885
8neurotransmitter catabolic process (GO:0042135)4.64960960
9regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.60966560
10regulation of p38MAPK cascade (GO:1900744)4.52162384
11post-embryonic morphogenesis (GO:0009886)4.49939115
12chemosensory behavior (GO:0007635)4.17580086
13cellular glucuronidation (GO:0052695)4.14256127
14melanin biosynthetic process (GO:0042438)4.12147086
15positive regulation of glomerulus development (GO:0090193)4.08526412
16xenobiotic catabolic process (GO:0042178)4.08025553
17coronary vasculature morphogenesis (GO:0060977)4.06478596
18glycine transport (GO:0015816)4.06256993
19cellular hyperosmotic response (GO:0071474)4.03619903
20endothelial cell chemotaxis (GO:0035767)4.02571125
21basic amino acid transport (GO:0015802)4.01126729
22cell volume homeostasis (GO:0006884)3.97700485
23pattern specification involved in kidney development (GO:0061004)3.93930301
24piRNA metabolic process (GO:0034587)3.90315852
25neuron maturation (GO:0042551)3.89225344
26nephron tubule formation (GO:0072079)3.85143026
27positive regulation of protein kinase C signaling (GO:0090037)3.82315147
28positive regulation of cell cycle checkpoint (GO:1901978)3.82139949
29positive regulation of vascular permeability (GO:0043117)3.78192173
30uronic acid metabolic process (GO:0006063)3.73160771
31glucuronate metabolic process (GO:0019585)3.73160771
32melanin metabolic process (GO:0006582)3.69502205
33regulation of cell maturation (GO:1903429)3.69359715
34metanephric nephron tubule development (GO:0072234)3.69110812
35metanephric tubule development (GO:0072170)3.69110812
36regulation of DNA methylation (GO:0044030)3.68758478
37lysine catabolic process (GO:0006554)3.66964215
38lysine metabolic process (GO:0006553)3.66964215
39negative regulation of metanephros development (GO:0072217)3.66848388
40secondary metabolite biosynthetic process (GO:0044550)3.65359624
41organic cation transport (GO:0015695)3.62535146
42positive regulation of cellular amine metabolic process (GO:0033240)3.59799049
43cranial nerve structural organization (GO:0021604)3.54933041
44regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.54131133
45response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.52788684
46multicellular organism reproduction (GO:0032504)3.52101809
47cochlea development (GO:0090102)3.48653414
48glutathione biosynthetic process (GO:0006750)3.44540094
49metanephric mesenchyme development (GO:0072075)3.44337580
50metanephric nephron epithelium development (GO:0072243)3.40707291
51cell differentiation involved in metanephros development (GO:0072202)3.38424954
52cAMP catabolic process (GO:0006198)3.36696406
53nonribosomal peptide biosynthetic process (GO:0019184)3.33802821
54surfactant homeostasis (GO:0043129)3.32520263
55eye photoreceptor cell development (GO:0042462)3.28382244
56cyclic nucleotide catabolic process (GO:0009214)3.26598155
57regulation of uterine smooth muscle contraction (GO:0070472)3.26073908
58regulation of endothelial cell chemotaxis (GO:2001026)3.20266874
59glutathione derivative metabolic process (GO:1901685)3.18883128
60glutathione derivative biosynthetic process (GO:1901687)3.18883128
61negative regulation of smooth muscle cell differentiation (GO:0051151)3.16476863
62photoreceptor cell development (GO:0042461)3.12653086
63histone lysine demethylation (GO:0070076)3.10833637
64sulfation (GO:0051923)3.09877210
65kidney mesenchyme development (GO:0072074)3.09795482
66mesonephros development (GO:0001823)3.08324053
67positive regulation of CREB transcription factor activity (GO:0032793)3.07685028
68positive regulation of microtubule polymerization (GO:0031116)3.07015898
69metanephric epithelium development (GO:0072207)3.05855967
70meiotic cell cycle (GO:0051321)3.05394977
71positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.05024340
72amino-acid betaine metabolic process (GO:0006577)3.01879095
73chemical homeostasis within a tissue (GO:0048875)2.99484802
74histone demethylation (GO:0016577)2.98583895
75vascular endothelial growth factor signaling pathway (GO:0038084)2.98568323
76cell morphogenesis involved in neuron differentiation (GO:0048667)2.98336781
77relaxation of smooth muscle (GO:0044557)2.97949594
78peptide biosynthetic process (GO:0043043)2.94303029
79regulation of acrosome reaction (GO:0060046)2.93862528
80brain morphogenesis (GO:0048854)2.92611471
81activation of JUN kinase activity (GO:0007257)2.91715299
82DNA methylation involved in gamete generation (GO:0043046)2.89190352
83myelin maintenance (GO:0043217)2.88841498
84auditory receptor cell stereocilium organization (GO:0060088)2.88710432
85drug transmembrane transport (GO:0006855)2.87676679
86arachidonic acid secretion (GO:0050482)2.84970308
87icosanoid secretion (GO:0032309)2.84970308
88aspartate family amino acid catabolic process (GO:0009068)2.83413069
89nephron tubule development (GO:0072080)2.83171403
90cAMP metabolic process (GO:0046058)2.79237121
91neuropeptide signaling pathway (GO:0007218)2.74376346
92regulation of vasculogenesis (GO:2001212)2.72108502
93regulation of macrophage chemotaxis (GO:0010758)2.70785339
94regulation of steroid hormone secretion (GO:2000831)2.70278226
95embryonic digestive tract development (GO:0048566)2.60094529
96nitric oxide biosynthetic process (GO:0006809)2.59677647
97cAMP biosynthetic process (GO:0006171)2.59651788
98regulation of glucose import in response to insulin stimulus (GO:2001273)2.59646839
99gamma-aminobutyric acid transport (GO:0015812)17.3300313
100glial cell proliferation (GO:0014009)10.5579156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67233793
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.48136425
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.37478296
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99255142
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.89228442
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86103714
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55599110
8DROSHA_22980978_ChIP-Seq_HELA_Human2.40693078
9GBX2_23144817_ChIP-Seq_PC3_Human2.26955872
10EGR1_19032775_ChIP-ChIP_M12_Human2.04761925
11AR_21572438_ChIP-Seq_LNCaP_Human1.90225535
12EED_16625203_ChIP-ChIP_MESCs_Mouse1.87990214
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87031979
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.86285438
15ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81163491
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59391848
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57907437
18RXR_22108803_ChIP-Seq_LS180_Human1.56511509
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54514372
20CBP_21632823_ChIP-Seq_H3396_Human1.53438497
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51554470
22P300_19829295_ChIP-Seq_ESCs_Human1.50622554
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.47609333
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45512716
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45448160
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.45041430
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.44809612
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.44740287
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44541485
30ZNF274_21170338_ChIP-Seq_K562_Hela1.44453558
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44290221
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43534719
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.39317251
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38331287
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.36609713
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36024655
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35555145
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.34593786
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33299288
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33299288
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32571466
42VDR_22108803_ChIP-Seq_LS180_Human1.32569566
43TAF15_26573619_Chip-Seq_HEK293_Human1.32321010
44AR_25329375_ChIP-Seq_VCAP_Human1.32290932
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31690473
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.29904598
47AHR_22903824_ChIP-Seq_MCF-7_Human1.29895648
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29832083
49VDR_24787735_ChIP-Seq_THP-1_Human1.29225711
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29068497
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27396924
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.27348392
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27157380
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27157380
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26227594
56ERG_20517297_ChIP-Seq_VCAP_Human1.25647865
57RUNX2_22187159_ChIP-Seq_PCA_Human1.24466702
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23959509
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22600039
60REST_21632747_ChIP-Seq_MESCs_Mouse1.22229998
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19816903
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19634682
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.17731986
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17239743
65STAT3_23295773_ChIP-Seq_U87_Human1.15685679
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15613969
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14931389
68SMAD4_21741376_ChIP-Seq_HESCs_Human1.14257661
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13631651
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12880425
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12642672
72SMRT_27268052_Chip-Seq_Bcells_Human1.11788545
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10786441
74AR_20517297_ChIP-Seq_VCAP_Human1.08566078
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08439175
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.07466172
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.06945209
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06945209
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06273929
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05760920
81NANOG_20526341_ChIP-Seq_ESCs_Human1.04898048
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04614267
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.04291828
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04212099
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03817040
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03437649
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02807384
88EWS_26573619_Chip-Seq_HEK293_Human1.02676958
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01663624
90TAF2_19829295_ChIP-Seq_ESCs_Human1.01558014
91SOX2_21211035_ChIP-Seq_LN229_Human1.01513530
92TCF4_23295773_ChIP-Seq_U87_Human1.01029525
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00140608
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.99640653
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98835051
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98340921
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97654484
98SMAD4_21799915_ChIP-Seq_A2780_Human0.94684553
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94456009
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.93451497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell4.57443198
2MP0005377_hearing/vestibular/ear_phenot4.14723021
3MP0003878_abnormal_ear_physiology4.14723021
4MP0003136_yellow_coat_color4.14675989
5MP0002735_abnormal_chemical_nociception3.47192865
6MP0003718_maternal_effect3.19341492
7MP0001501_abnormal_sleep_pattern3.03584522
8MP0003183_abnormal_peptide_metabolism2.85951006
9MP0002822_catalepsy2.85029444
10MP0000372_irregular_coat_pigmentation2.84243072
11MP0002638_abnormal_pupillary_reflex2.81830060
12MP0005360_urolithiasis2.25713827
13MP0005171_absent_coat_pigmentation2.03582326
14MP0008875_abnormal_xenobiotic_pharmacok2.03089721
15MP0001485_abnormal_pinna_reflex1.99001493
16MP0005257_abnormal_intraocular_pressure1.93113466
17MP0001324_abnormal_eye_pigmentation1.92638361
18MP0008569_lethality_at_weaning1.92412239
19MP0003690_abnormal_glial_cell1.90714934
20MP0004147_increased_porphyrin_level1.89851671
21MP0002272_abnormal_nervous_system1.86397269
22MP0005187_abnormal_penis_morphology1.85568049
23MP0002095_abnormal_skin_pigmentation1.84985299
24MP0002557_abnormal_social/conspecific_i1.83513144
25MP0003632_abnormal_nervous_system1.83494693
26MP0003315_abnormal_perineum_morphology1.83278420
27MP0002138_abnormal_hepatobiliary_system1.83268113
28MP0001348_abnormal_lacrimal_gland1.82452859
29MP0002736_abnormal_nociception_after1.79271198
30MP0000013_abnormal_adipose_tissue1.73706312
31MP0000015_abnormal_ear_pigmentation1.69592805
32MP0005551_abnormal_eye_electrophysiolog1.66506052
33MP0005332_abnormal_amino_acid1.65618196
34MP0002160_abnormal_reproductive_system1.59434979
35MP0005058_abnormal_lysosome_morphology1.57519605
36MP0003252_abnormal_bile_duct1.56751289
37MP0001963_abnormal_hearing_physiology1.44404117
38MP0005174_abnormal_tail_pigmentation1.42825358
39MP0001968_abnormal_touch/_nociception1.36800315
40MP0002229_neurodegeneration1.35996232
41MP0005408_hypopigmentation1.34560421
42MP0003329_amyloid_beta_deposits1.29965625
43MP0003959_abnormal_lean_body1.28913017
44MP0008789_abnormal_olfactory_epithelium1.27168435
45MP0000427_abnormal_hair_cycle1.27101103
46MP0005253_abnormal_eye_physiology1.26708865
47MP0002067_abnormal_sensory_capabilities1.23523058
48MP0000920_abnormal_myelination1.21777968
49MP0000647_abnormal_sebaceous_gland1.21538839
50MP0006072_abnormal_retinal_apoptosis1.17546461
51MP0009745_abnormal_behavioral_response1.16340412
52MP0002653_abnormal_ependyma_morphology1.12406251
53MP0009384_cardiac_valve_regurgitation1.12096394
54MP0004019_abnormal_vitamin_homeostasis1.11721367
55MP0000026_abnormal_inner_ear1.10008439
56MP0005499_abnormal_olfactory_system1.09236540
57MP0005394_taste/olfaction_phenotype1.09236540
58MP0008877_abnormal_DNA_methylation1.06865190
59MP0002909_abnormal_adrenal_gland1.05804611
60MP0002210_abnormal_sex_determination1.04916475
61MP0001879_abnormal_lymphatic_vessel1.04522668
62MP0001929_abnormal_gametogenesis1.04224757
63MP0001502_abnormal_circadian_rhythm1.01460104
64MP0001486_abnormal_startle_reflex1.00137954
65MP0009046_muscle_twitch0.99756180
66MP0003950_abnormal_plasma_membrane0.98948608
67MP0000383_abnormal_hair_follicle0.98549079
68MP0002572_abnormal_emotion/affect_behav0.97445327
69MP0005395_other_phenotype0.96628502
70MP0005266_abnormal_metabolism0.96254063
71MP0005410_abnormal_fertilization0.95931103
72MP0001664_abnormal_digestion0.94289149
73MP0003638_abnormal_response/metabolism_0.94160700
74MP0000678_abnormal_parathyroid_gland0.93725146
75MP0003890_abnormal_embryonic-extraembry0.87746732
76MP0010678_abnormal_skin_adnexa0.86948645
77MP0003699_abnormal_female_reproductive0.86795430
78MP0003011_delayed_dark_adaptation0.85946953
79MP0010386_abnormal_urinary_bladder0.85663765
80MP0002089_abnormal_postnatal_growth/wei0.84087396
81MP0004742_abnormal_vestibular_system0.83962011
82MP0003698_abnormal_male_reproductive0.82240849
83MP0003634_abnormal_glial_cell0.81490119
84MP0004085_abnormal_heartbeat0.80840542
85MP0002928_abnormal_bile_duct0.80134734
86MP0002269_muscular_atrophy0.79419862
87MP0002733_abnormal_thermal_nociception0.79139313
88MP0008872_abnormal_physiological_respon0.77751455
89MP0005389_reproductive_system_phenotype0.77672380
90MP0003631_nervous_system_phenotype0.75565189
91MP0001919_abnormal_reproductive_system0.74761147
92MP0002752_abnormal_somatic_nervous0.74582910
93MP0005075_abnormal_melanosome_morpholog0.74073781
94MP0001756_abnormal_urination0.73902588
95MP0001851_eye_inflammation0.73781001
96MP0002161_abnormal_fertility/fecundity0.73096102
97MP0005195_abnormal_posterior_eye0.72821710
98MP0002876_abnormal_thyroid_physiology0.71681800
99MP0000569_abnormal_digit_pigmentation0.71262545
100MP0002102_abnormal_ear_morphology0.69760080

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)9.11592212
2Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)6.33346665
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.17699788
4Congenital stationary night blindness (HP:0007642)5.06103160
5Cholecystitis (HP:0001082)4.64723602
6Abnormal gallbladder physiology (HP:0012438)4.64723602
7Polar cataract (HP:0010696)4.63145561
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.60475492
9Chromsome breakage (HP:0040012)4.48725765
10Increased cerebral lipofuscin (HP:0011813)4.22614453
11Hypoplasia of the fovea (HP:0007750)3.91323913
12Aplasia/Hypoplasia of the fovea (HP:0008060)3.91323913
13Zonular cataract (HP:0010920)3.85267592
14Spastic paraparesis (HP:0002313)3.78344954
15Neurofibrillary tangles (HP:0002185)3.64375277
16Abnormal biliary tract physiology (HP:0012439)3.63360694
17Bile duct proliferation (HP:0001408)3.63360694
18Abnormality of macular pigmentation (HP:0008002)3.53522161
19Bilateral sensorineural hearing impairment (HP:0008619)3.50688257
20Aplasia/Hypoplasia of the macula (HP:0008059)3.42384911
21Congenital sensorineural hearing impairment (HP:0008527)3.40744467
22Osteomalacia (HP:0002749)3.26370883
23Aplasia/Hypoplasia affecting the retina (HP:0008061)3.22066717
24Abolished electroretinogram (ERG) (HP:0000550)3.21580946
25Potter facies (HP:0002009)3.20902662
26Facial shape deformation (HP:0011334)3.20902662
27Abnormality of the fovea (HP:0000493)3.18240366
28Aplastic anemia (HP:0001915)3.01039865
29Reticulocytopenia (HP:0001896)2.98720539
30Diplopia (HP:0000651)2.96851169
31Abnormality of binocular vision (HP:0011514)2.96851169
32Chorioretinal atrophy (HP:0000533)2.96036992
33Bicornuate uterus (HP:0000813)2.83597334
34Myokymia (HP:0002411)2.81943275
35Posterior subcapsular cataract (HP:0007787)2.79606867
36Retinal atrophy (HP:0001105)2.78175981
37Abnormal auditory evoked potentials (HP:0006958)2.73624761
38Hypercortisolism (HP:0001578)2.70141655
39Hypophosphatemic rickets (HP:0004912)2.67707427
40Focal segmental glomerulosclerosis (HP:0000097)2.61939744
41Hemiparesis (HP:0001269)2.58482055
42Supernumerary spleens (HP:0009799)2.54090812
43Vacuolated lymphocytes (HP:0001922)2.53130791
44Abnormality of midbrain morphology (HP:0002418)2.52121658
45Molar tooth sign on MRI (HP:0002419)2.52121658
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45748836
47Hyperglycinuria (HP:0003108)2.42983667
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.36354124
49Abnormality of the renal collecting system (HP:0004742)2.34961950
50Duplicated collecting system (HP:0000081)2.34387450
51Subcapsular cataract (HP:0000523)2.33224692
52Confusion (HP:0001289)2.30785811
53Cerebral inclusion bodies (HP:0100314)2.25718856
54Azoospermia (HP:0000027)2.24569219
55Macular degeneration (HP:0000608)2.21110842
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21024708
57Global brain atrophy (HP:0002283)2.15555327
58Renal dysplasia (HP:0000110)2.13296671
59Hydroxyprolinuria (HP:0003080)2.09474837
60Abnormality of proline metabolism (HP:0010907)2.09474837
61White forelock (HP:0002211)2.06223297
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.04542965
63Optic nerve coloboma (HP:0000588)2.03964833
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02670121
65Patchy hypopigmentation of hair (HP:0011365)2.01410873
66Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00522577
67Short tibia (HP:0005736)1.97973604
68Abnormality of calcium-phosphate metabolism (HP:0100530)1.97769168
69Axonal loss (HP:0003447)1.97673734
70Pili torti (HP:0003777)1.96130500
71Anterior segment dysgenesis (HP:0007700)1.95321994
72Clubbing of toes (HP:0100760)1.95088899
73Paraparesis (HP:0002385)1.94865305
74Attenuation of retinal blood vessels (HP:0007843)1.94133530
75Impulsivity (HP:0100710)1.90802050
76Blue irides (HP:0000635)1.89455097
77Bifid tongue (HP:0010297)1.88283820
78Hypoplasia of the iris (HP:0007676)1.88117252
79Adrenal overactivity (HP:0002717)1.87132429
80Impaired smooth pursuit (HP:0007772)1.81362107
81Abnormality of the anterior chamber (HP:0000593)1.78143263
82Glomerulosclerosis (HP:0000096)1.75662020
83Lip pit (HP:0100267)1.75351615
84Tachypnea (HP:0002789)1.74511382
85Ketosis (HP:0001946)1.74066913
86Meckel diverticulum (HP:0002245)1.72841379
87Anosmia (HP:0000458)1.72557337
88Genital tract atresia (HP:0001827)1.72504451
89Progressive visual loss (HP:0000529)1.71917472
90Abnormality of the preputium (HP:0100587)1.71303684
91Enlarged kidneys (HP:0000105)1.69402103
92Decreased circulating renin level (HP:0003351)1.69391275
93Albinism (HP:0001022)1.65964638
94Segmental peripheral demyelination/remyelination (HP:0003481)1.65387035
95Abnormality of chromosome stability (HP:0003220)1.63558554
96Truncal obesity (HP:0001956)1.62124605
97Abnormality of the ileum (HP:0001549)1.60620317
98Conjunctival telangiectasia (HP:0000524)1.60030591
99Abnormal spermatogenesis (HP:0008669)1.59210659
100Ocular albinism (HP:0001107)1.58542168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K65.83084864
2GRK15.77426808
3ARAF3.08378974
4ADRBK22.83609988
5MAP3K92.83324831
6MAP3K132.83100015
7NTRK32.81279526
8INSRR2.43382134
9NEK62.10683850
10FRK1.95719114
11MAPKAPK31.94396651
12STK381.89962799
13MAPK151.77434309
14BCKDK1.76723266
15KDR1.71648800
16LATS11.68905586
17BMPR1B1.67453858
18STK38L1.64809658
19STK241.56556772
20KSR21.51465982
21PINK11.45970218
22NME11.29842481
23KIT1.27433296
24ADRBK11.26956856
25MET1.24579387
26WEE11.20110377
27MAP2K11.16738785
28TAOK31.14366213
29PRKD31.13913653
30CDK31.12537899
31PRKCI1.12162187
32DYRK1A1.11454578
33MST41.09658117
34EPHA21.02032613
35BRAF1.01369230
36SGK2231.01282285
37SGK4941.01282285
38PDK21.00961248
39ACVR1B1.00811784
40STK30.98412448
41MAPK120.90362287
42AURKA0.88003695
43TGFBR10.87789045
44PTK2B0.83272498
45NEK90.82610201
46CDK90.82383870
47RAF10.81652014
48ERN10.79715107
49PRKCH0.79457287
50TRIB30.78488935
51IRAK10.75416038
52SIK10.75346039
53VRK10.75193241
54MAP3K10.73969350
55GSK3A0.71786455
56MAPK130.69974834
57PHKG20.69806289
58PHKG10.69806289
59NEK20.69099078
60TIE10.68967084
61PRKAA20.68071280
62MAP3K40.67545517
63CCNB10.65213645
64PRKCG0.63734869
65SIK20.63020975
66MAP3K70.61558030
67CAMKK10.61374617
68PRKACA0.61062685
69MOS0.60329419
70CDK70.60087541
71DDR20.59744291
72IRAK20.59217070
73CDK120.58721069
74PRKD20.57696668
75CSF1R0.55573128
76LRRK20.54501793
77NTRK20.51562298
78CHUK0.51220503
79GRK60.49888009
80FLT30.48805489
81NUAK10.47816366
82TBK10.47702554
83FER0.46945485
84MARK30.46103780
85PLK20.44351557
86PDPK10.43895958
87STK390.43602273
88TNK20.43321513
89PRKCE0.43035695
90PRKCZ0.41048953
91MKNK20.41040059
92PKN10.40292548
93MAP4K20.38092340
94AKT20.37877079
95RPS6KB20.37141301
96EEF2K0.36746990
97CSNK1D0.33837008
98PDK10.33033109
99PRKACB0.32927068
100FGFR30.32914034

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003404.11051024
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.03622724
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.86320000
4Arginine and proline metabolism_Homo sapiens_hsa003302.91607347
5Butanoate metabolism_Homo sapiens_hsa006502.66985679
6Ovarian steroidogenesis_Homo sapiens_hsa049132.62979071
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36992084
8Nitrogen metabolism_Homo sapiens_hsa009102.20374649
9Linoleic acid metabolism_Homo sapiens_hsa005912.15986025
10Tryptophan metabolism_Homo sapiens_hsa003802.10476760
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99639110
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88845151
13Arginine biosynthesis_Homo sapiens_hsa002201.85071562
14Fructose and mannose metabolism_Homo sapiens_hsa000511.83894558
15GABAergic synapse_Homo sapiens_hsa047271.82410011
16beta-Alanine metabolism_Homo sapiens_hsa004101.80787380
17Ether lipid metabolism_Homo sapiens_hsa005651.73993328
18Starch and sucrose metabolism_Homo sapiens_hsa005001.73755683
19Chemical carcinogenesis_Homo sapiens_hsa052041.69556558
20Phototransduction_Homo sapiens_hsa047441.66490183
21Bile secretion_Homo sapiens_hsa049761.57582593
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56431442
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38440968
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.34755937
25Lysine degradation_Homo sapiens_hsa003101.24243796
26Olfactory transduction_Homo sapiens_hsa047401.23229407
27Retinol metabolism_Homo sapiens_hsa008301.21036924
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19785239
29Morphine addiction_Homo sapiens_hsa050321.18025303
30Fatty acid biosynthesis_Homo sapiens_hsa000611.16577426
31ABC transporters_Homo sapiens_hsa020101.13696256
32Basal transcription factors_Homo sapiens_hsa030221.13015231
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12887498
34Arachidonic acid metabolism_Homo sapiens_hsa005901.10793880
35Small cell lung cancer_Homo sapiens_hsa052221.09318610
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08199193
37Circadian rhythm_Homo sapiens_hsa047101.07581353
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04223892
39Biosynthesis of amino acids_Homo sapiens_hsa012301.02041181
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01124019
41Other glycan degradation_Homo sapiens_hsa005110.98958181
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.94200078
43Fatty acid degradation_Homo sapiens_hsa000710.93537058
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91743599
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91620249
46Collecting duct acid secretion_Homo sapiens_hsa049660.90885549
47Glutathione metabolism_Homo sapiens_hsa004800.89791256
48Vitamin digestion and absorption_Homo sapiens_hsa049770.87641410
49Taste transduction_Homo sapiens_hsa047420.86817396
50Oxidative phosphorylation_Homo sapiens_hsa001900.84543508
51One carbon pool by folate_Homo sapiens_hsa006700.84535714
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83985481
53Serotonergic synapse_Homo sapiens_hsa047260.83369124
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83249037
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82698474
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81821207
57Parkinsons disease_Homo sapiens_hsa050120.80171440
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76986451
59Protein digestion and absorption_Homo sapiens_hsa049740.73789787
60Phenylalanine metabolism_Homo sapiens_hsa003600.73398555
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.73349333
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.71869625
63Fatty acid elongation_Homo sapiens_hsa000620.71057875
64Dorso-ventral axis formation_Homo sapiens_hsa043200.68717609
65Cardiac muscle contraction_Homo sapiens_hsa042600.67229300
66Glycerolipid metabolism_Homo sapiens_hsa005610.67148625
67Propanoate metabolism_Homo sapiens_hsa006400.63534341
68Glutamatergic synapse_Homo sapiens_hsa047240.53782983
69Fanconi anemia pathway_Homo sapiens_hsa034600.53326096
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51983741
71Pentose phosphate pathway_Homo sapiens_hsa000300.51615553
72Salivary secretion_Homo sapiens_hsa049700.51573852
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.51345219
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49385783
75Circadian entrainment_Homo sapiens_hsa047130.48115217
76Huntingtons disease_Homo sapiens_hsa050160.47915011
77Sphingolipid metabolism_Homo sapiens_hsa006000.47729593
78HIF-1 signaling pathway_Homo sapiens_hsa040660.47309429
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45763630
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45213676
81Tyrosine metabolism_Homo sapiens_hsa003500.45203285
82Alzheimers disease_Homo sapiens_hsa050100.44980876
83Thyroid hormone synthesis_Homo sapiens_hsa049180.44772443
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44610351
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44434273
86Metabolic pathways_Homo sapiens_hsa011000.44144713
87Galactose metabolism_Homo sapiens_hsa000520.44018562
88RNA degradation_Homo sapiens_hsa030180.43138933
89Caffeine metabolism_Homo sapiens_hsa002320.42483957
90Insulin secretion_Homo sapiens_hsa049110.40469737
91Calcium signaling pathway_Homo sapiens_hsa040200.39960439
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39001416
93cAMP signaling pathway_Homo sapiens_hsa040240.38210607
94Cell cycle_Homo sapiens_hsa041100.37519101
95Pancreatic secretion_Homo sapiens_hsa049720.36753762
96Renin-angiotensin system_Homo sapiens_hsa046140.36328321
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.36171599
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35994975
99Melanoma_Homo sapiens_hsa052180.33742774
100mTOR signaling pathway_Homo sapiens_hsa041500.32095265

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