ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.27500644
2	L-phenylalanine catabolic process (GO:0006559)	7.27500644
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.03494787
4	L-phenylalanine metabolic process (GO:0006558)	7.03494787
5	aromatic amino acid family catabolic process (GO:0009074)	6.51367301
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.19522884
7	indole-containing compound catabolic process (GO:0042436)	5.84571114
8	indolalkylamine catabolic process (GO:0046218)	5.84571114
9	tryptophan catabolic process (GO:0006569)	5.84571114
10	negative regulation of fibrinolysis (GO:0051918)	5.76211921
11	kynurenine metabolic process (GO:0070189)	5.75548259
12	bile acid biosynthetic process (GO:0006699)	5.71341128
13	glyoxylate metabolic process (GO:0046487)	5.63886100
14	tryptophan metabolic process (GO:0006568)	5.50121194
15	regulation of fibrinolysis (GO:0051917)	5.48124644
16	alpha-linolenic acid metabolic process (GO:0036109)	5.46994343
17	peptidyl-glutamic acid carboxylation (GO:0017187)	5.41948718
18	protein carboxylation (GO:0018214)	5.41948718
19	urea metabolic process (GO:0019627)	5.41464869
20	urea cycle (GO:0000050)	5.41464869
21	high-density lipoprotein particle remodeling (GO:0034375)	5.41197739
22	sulfur amino acid catabolic process (GO:0000098)	5.32606113
23	cysteine metabolic process (GO:0006534)	5.28257674
24	regulation of protein activation cascade (GO:2000257)	5.20884429
25	complement activation, alternative pathway (GO:0006957)	5.15672193
26	epoxygenase P450 pathway (GO:0019373)	5.14863558
27	nitrogen cycle metabolic process (GO:0071941)	4.98421993
28	serine family amino acid catabolic process (GO:0009071)	4.92532057
29	regulation of complement activation (GO:0030449)	4.89147064
30	bile acid metabolic process (GO:0008206)	4.83848884
31	reverse cholesterol transport (GO:0043691)	4.79901604
32	homocysteine metabolic process (GO:0050667)	4.78563043
33	regulation of cholesterol esterification (GO:0010872)	4.72529398
34	aromatic amino acid family metabolic process (GO:0009072)	4.71306815
35	regulation of triglyceride catabolic process (GO:0010896)	4.68281448
36	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.66451839
37	plasma lipoprotein particle remodeling (GO:0034369)	4.66127786
38	protein-lipid complex remodeling (GO:0034368)	4.66127786
39	macromolecular complex remodeling (GO:0034367)	4.66127786
40	tyrosine metabolic process (GO:0006570)	4.58397137
41	lysine catabolic process (GO:0006554)	4.57598969
42	lysine metabolic process (GO:0006553)	4.57598969
43	amino-acid betaine metabolic process (GO:0006577)	4.48698689
44	alpha-amino acid catabolic process (GO:1901606)	4.48403295
45	triglyceride homeostasis (GO:0070328)	4.47137189
46	acylglycerol homeostasis (GO:0055090)	4.47137189
47	glycine metabolic process (GO:0006544)	4.42473843
48	negative regulation of sterol transport (GO:0032372)	4.41565829
49	negative regulation of cholesterol transport (GO:0032375)	4.41565829
50	phospholipid efflux (GO:0033700)	4.36111365
51	plasma lipoprotein particle clearance (GO:0034381)	4.34139755
52	cellular glucuronidation (GO:0052695)	4.32014799
53	exogenous drug catabolic process (GO:0042738)	4.31145326
54	coenzyme catabolic process (GO:0009109)	4.27865100
55	cellular ketone body metabolic process (GO:0046950)	4.22028319
56	serine family amino acid biosynthetic process (GO:0009070)	4.20771775
57	serine family amino acid metabolic process (GO:0009069)	4.18403835
58	fibrinolysis (GO:0042730)	4.17604736
59	bile acid and bile salt transport (GO:0015721)	4.15781923
60	glutamate metabolic process (GO:0006536)	4.15164021
61	omega-hydroxylase P450 pathway (GO:0097267)	4.15020449
62	cellular amino acid catabolic process (GO:0009063)	4.14333458
63	imidazole-containing compound metabolic process (GO:0052803)	4.10733743
64	cellular modified amino acid catabolic process (GO:0042219)	4.10709812
65	cellular biogenic amine catabolic process (GO:0042402)	4.10094764
66	amine catabolic process (GO:0009310)	4.10094764
67	indolalkylamine metabolic process (GO:0006586)	4.08883037
68	ethanol oxidation (GO:0006069)	4.02427313
69	negative regulation of hemostasis (GO:1900047)	4.01886626
70	negative regulation of blood coagulation (GO:0030195)	4.01886626
71	cholesterol efflux (GO:0033344)	4.01673424
72	drug metabolic process (GO:0017144)	3.94642910
73	plasma lipoprotein particle assembly (GO:0034377)	3.93906431
74	low-density lipoprotein particle remodeling (GO:0034374)	3.93745390
75	dicarboxylic acid biosynthetic process (GO:0043650)	3.90724230
76	arginine metabolic process (GO:0006525)	3.90340180
77	benzene-containing compound metabolic process (GO:0042537)	3.89571733
78	aldehyde catabolic process (GO:0046185)	3.84749314
79	acute-phase response (GO:0006953)	3.83342713
80	glucuronate metabolic process (GO:0019585)	3.82883863
81	uronic acid metabolic process (GO:0006063)	3.82883863
82	negative regulation of coagulation (GO:0050819)	3.80724625
83	regulation of plasminogen activation (GO:0010755)	3.79065877
84	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.73800239
85	very-low-density lipoprotein particle assembly (GO:0034379)	3.73357897
86	positive regulation of lipid catabolic process (GO:0050996)	3.71902485
87	regulation of cholesterol homeostasis (GO:2000188)	3.69832740
88	blood coagulation, intrinsic pathway (GO:0007597)	3.68755909
89	cofactor catabolic process (GO:0051187)	3.68211876
90	ethanol metabolic process (GO:0006067)	3.65603269
91	ketone body metabolic process (GO:1902224)	3.63994892
92	intestinal cholesterol absorption (GO:0030299)	3.63866901
93	negative regulation of wound healing (GO:0061045)	3.63800089
94	cholesterol homeostasis (GO:0042632)	3.63743400
95	negative regulation of lipase activity (GO:0060192)	3.63130709
96	negative regulation of protein activation cascade (GO:2000258)	3.62093198
97	carboxylic acid catabolic process (GO:0046395)	3.61707959
98	organic acid catabolic process (GO:0016054)	3.61707959
99	complement activation, classical pathway (GO:0006958)	3.60543342
100	protein-lipid complex assembly (GO:0065005)	3.60303183
101	positive regulation of triglyceride lipase activity (GO:0061365)	3.60151903
102	positive regulation of lipoprotein lipase activity (GO:0051006)	3.60151903
103	protein activation cascade (GO:0072376)	3.59583434
104	complement activation (GO:0006956)	3.59379800
105	sterol homeostasis (GO:0055092)	3.58495517
106	plasma lipoprotein particle organization (GO:0071827)	3.57905339
107	regulation of bile acid biosynthetic process (GO:0070857)	3.57286989
108	phospholipid homeostasis (GO:0055091)	3.56523035
109	short-chain fatty acid metabolic process (GO:0046459)	3.55470034
110	acetyl-CoA metabolic process (GO:0006084)	3.53131367
111	cytolysis (GO:0019835)	3.51450382
112	intestinal absorption (GO:0050892)	3.49771368
113	drug catabolic process (GO:0042737)	3.48487616
114	basement membrane organization (GO:0071711)	3.45454788
115	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.43353616
116	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.38569862
117	positive regulation of extracellular matrix organization (GO:1903055)	3.37630089
118	negative regulation of complement activation (GO:0045916)	3.27773766
119	protein-lipid complex subunit organization (GO:0071825)	3.26989150
120	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.23125894
121	positive regulation of hemostasis (GO:1900048)	3.17759279
122	positive regulation of blood coagulation (GO:0030194)	3.17759279
123	proline metabolic process (GO:0006560)	3.16871881
124	regulation of apoptotic cell clearance (GO:2000425)	3.15632133
125	hormone catabolic process (GO:0042447)	3.15113622
126	lipoprotein metabolic process (GO:0042157)	3.09732395
127	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.06998552
128	regulation of humoral immune response (GO:0002920)	3.02972400
129	adhesion of symbiont to host (GO:0044406)	3.02238428
130	fat-soluble vitamin biosynthetic process (GO:0042362)	2.97737808
131	positive regulation of coagulation (GO:0050820)	2.95875001
132	acute inflammatory response (GO:0002526)	2.94032903
133	positive regulation of triglyceride metabolic process (GO:0090208)	2.92995871
134	diacylglycerol metabolic process (GO:0046339)	2.92209558
135	flavonoid metabolic process (GO:0009812)	2.85887790
136	opsonization (GO:0008228)	2.84418087
137	low-density lipoprotein particle clearance (GO:0034383)	2.84280538
138	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	2.82340881
139	phenylpropanoid metabolic process (GO:0009698)	2.81652154
140	protein heterotrimerization (GO:0070208)	2.79325205
141	glutamine family amino acid biosynthetic process (GO:0009084)	2.76906692

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	8.20315675
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.04843848
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.51091900
4	* LXR_22158963_ChIP-Seq_LIVER_Mouse	6.33491570
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.21323406
6	* FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.91859882
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.85949450
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.94977144
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.70452093
10	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.39432741
11	* ELK3_25401928_ChIP-Seq_HUVEC_Human	2.31764554
12	CLOCK_20551151_ChIP-Seq_293T_Human	2.22954899
13	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.05716439
14	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.00560831
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.7535570
16	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.88804390
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.70740486
18	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.64957818
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.60322707
20	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.55297187
21	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.53535332
22	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.44538885
23	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.37806209
24	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.36087839
25	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.34437533
26	VDR_21846776_ChIP-Seq_THP-1_Human	1.34083462
27	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.33901834
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.33660962
29	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.32508262
30	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.27911998
31	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.25823327
32	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.25247475
33	TP53_22127205_ChIP-Seq_IMR90_Human	1.22043690
34	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.21163763
35	HTT_18923047_ChIP-ChIP_STHdh_Human	1.20666276
36	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.18766418
37	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.16517759
38	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.15117069
39	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.13869469
40	GATA1_22025678_ChIP-Seq_K562_Human	1.13222187
41	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.10764414
42	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.10543599
43	* P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.10457517
44	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.09239092
45	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.07846825
46	P68_20966046_ChIP-Seq_HELA_Human	1.07007620
47	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.06640655
48	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.06561196
49	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.06301894
50	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.03456049
51	KDM2B_26808549_Chip-Seq_K562_Human	1.02334547
52	SMC4_20622854_ChIP-Seq_HELA_Human	1.01888089
53	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.00086035
54	* CTCF_27219007_Chip-Seq_Bcells_Human	0.99202147
55	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.98925974
56	* ZNF263_19887448_ChIP-Seq_K562_Human	0.98849324
57	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.98118188
58	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96334250
59	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.94844209
60	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.94229762
61	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.94034024
62	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.93984928
63	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.93562939
64	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.93562939
65	SA1_27219007_Chip-Seq_Bcells_Human	0.92697689
66	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.92100595
67	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91952597
68	* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.91865946
69	BCL6_27268052_Chip-Seq_Bcells_Human	0.91597633
70	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.91546563
71	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.91040754
72	BCOR_27268052_Chip-Seq_Bcells_Human	0.90635195
73	VDR_24763502_ChIP-Seq_THP-1_Human	0.89991141
74	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.87881181
75	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.87852151
76	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.87248843
77	* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.86901661
78	* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.84931669
79	GATA4_25053715_ChIP-Seq_YYC3_Human	0.84381858
80	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.83312324
81	* LXR_22292898_ChIP-Seq_THP-1_Human	0.79998153
82	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.78013411
83	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.75990135
84	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.74071942
85	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.73917039
86	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.72638471
87	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.66946282
88	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.66782481
89	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.65846163
90	* RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.64145693
91	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.63737307
92	* ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.63290799
93	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.63058417
94	* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.62413577
95	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.61283634
96	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.60455706
97	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.60048609
98	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.59336851
99	RACK7_27058665_Chip-Seq_MCF-7_Human	0.59093091
100	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.59024350
101	* ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.58654639
102	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.57812950
103	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.56630585
104	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.55762633
105	EGR1_19032775_ChIP-ChIP_M12_Human	0.55750680
106	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.55150688
107	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.53148714
108	SOX2_20726797_ChIP-Seq_SW620_Human	0.52513835
109	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.52422554
110	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.50214668
111	CEBPB_22108803_ChIP-Seq_LS180_Human	0.49124037
112	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.48695072
113	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.48315531
114	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.47570322
115	AR_20517297_ChIP-Seq_VCAP_Human	0.47549103
116	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.47023681
117	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.46459347
118	GATA6_25053715_ChIP-Seq_YYC3_Human	0.46190240
119	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.46084440
120	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.45963496
121	ATF3_27146783_Chip-Seq_COLON_Human	0.45852051
122	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.44652519
123	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.44074013
124	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.44074013
125	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.43863753
126	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.43795341
127	GATA1_19941826_ChIP-Seq_K562_Human	0.43435687
128	MYC_19915707_ChIP-ChIP_AK7_Human	0.42859343
129	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.41579991
130	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.41577193
131	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.41393919
132	* CBP_21632823_ChIP-Seq_H3396_Human	0.41070658
133	P53_21459846_ChIP-Seq_SAOS-2_Human	0.40320182
134	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.40165780
135	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.39902843
136	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.39897148
137	CJUN_26792858_Chip-Seq_BT549_Human	0.39610951
138	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.39609397
139	GATA2_19941826_ChIP-Seq_K562_Human	0.39545270
140	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.38852972

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.10825320
2	MP0005360_urolithiasis	7.26994345
3	MP0005085_abnormal_gallbladder_physiolo	6.00805632
4	MP0005365_abnormal_bile_salt	5.78338397
5	MP0008875_abnormal_xenobiotic_pharmacok	4.64459649
6	MP0003806_abnormal_nucleotide_metabolis	3.98732932
7	MP0003252_abnormal_bile_duct	3.84015838
8	MP0010329_abnormal_lipoprotein_level	3.37981885
9	MP0009840_abnormal_foam_cell	3.30980368
10	MP0005083_abnormal_biliary_tract	2.90420490
11	MP0003195_calcinosis	2.84422403
12	MP0005332_abnormal_amino_acid	2.70112333
13	MP0001666_abnormal_nutrient_absorption	2.40065485
14	MP0003191_abnormal_cellular_cholesterol	2.10019799
15	MP0003705_abnormal_hypodermis_morpholog	2.08682388
16	MP0000609_abnormal_liver_physiology	2.07562645
17	MP0002118_abnormal_lipid_homeostasis	1.97984608
18	MP0005058_abnormal_lysosome_morphology	1.96895361
19	MP0004019_abnormal_vitamin_homeostasis	1.95085140
20	MP0005257_abnormal_intraocular_pressure	1.91603669
21	MP0003868_abnormal_feces_composition	1.86218847
22	MP0004858_abnormal_nervous_system	1.83384530
23	MP0002138_abnormal_hepatobiliary_system	1.79076536
24	MP0001958_emphysema	1.76320617
25	MP0005319_abnormal_enzyme/_coenzyme	1.75751777
26	MP0008438_abnormal_cutaneous_collagen	1.73970491
27	MP0009697_abnormal_copulation	1.55325889
28	MP0005584_abnormal_enzyme/coenzyme_acti	1.44438167
29	MP0003011_delayed_dark_adaptation	1.42072710
30	MP0001764_abnormal_homeostasis	1.38608136
31	MP0006054_spinal_hemorrhage	1.35581720
32	MP0003656_abnormal_erythrocyte_physiolo	1.33174979
33	MP0003566_abnormal_cell_adhesion	1.31080924
34	MP0010368_abnormal_lymphatic_system	1.28640811
35	MP0003186_abnormal_redox_activity	1.28404286
36	MP0005451_abnormal_body_composition	1.21876377
37	MP0000598_abnormal_liver_morphology	1.18742050
38	MP0009643_abnormal_urine_homeostasis	1.17769083
39	MP0009053_abnormal_anal_canal	1.09434327
40	MP0003172_abnormal_lysosome_physiology	1.07689381
41	MP0002254_reproductive_system_inflammat	1.06771402
42	MP0005508_abnormal_skeleton_morphology	1.06317379
43	MP0009384_cardiac_valve_regurgitation	1.03791610
44	MP0002089_abnormal_postnatal_growth/wei	1.02521084
45	MP0005647_abnormal_sex_gland	1.00503908
46	MP0002249_abnormal_larynx_morphology	0.97668194
47	MP0009764_decreased_sensitivity_to	0.97082218
48	MP0009763_increased_sensitivity_to	0.96695263
49	MP0000003_abnormal_adipose_tissue	0.95941744
50	MP0002933_joint_inflammation	0.95596543
51	MP0000604_amyloidosis	0.93338519
52	MP0000751_myopathy	0.89680849
53	MP0005670_abnormal_white_adipose	0.88860987
54	MP0005375_adipose_tissue_phenotype	0.87115272
55	MP0000013_abnormal_adipose_tissue	0.85696652
56	MP0005220_abnormal_exocrine_pancreas	0.85492524
57	MP0000858_altered_metastatic_potential	0.84084471
58	MP0005636_abnormal_mineral_homeostasis	0.82876942
59	MP0005084_abnormal_gallbladder_morpholo	0.82112752
60	MP0001533_abnormal_skeleton_physiology	0.81915728
61	MP0002998_abnormal_bone_remodeling	0.81791245
62	MP0000678_abnormal_parathyroid_gland	0.80268217
63	MP0005275_abnormal_skin_tensile	0.80095187
64	MP0002971_abnormal_brown_adipose	0.79298033
65	MP0008469_abnormal_protein_level	0.79128195
66	MP0009642_abnormal_blood_homeostasis	0.78961760
67	MP0001849_ear_inflammation	0.78400735
68	MP0010030_abnormal_orbit_morphology	0.77537262
69	MP0005390_skeleton_phenotype	0.77095107
70	MP0005408_hypopigmentation	0.75114875
71	MP0005409_darkened_coat_color	0.73807555
72	MP0003091_abnormal_cell_migration	0.73661267
73	MP0005376_homeostasis/metabolism_phenot	0.72389469
74	MP0003950_abnormal_plasma_membrane	0.71637205
75	MP0002060_abnormal_skin_morphology	0.71593888
76	MP0009780_abnormal_chondrocyte_physiolo	0.70539472
77	MP0001243_abnormal_dermal_layer	0.69046454
78	MP0005334_abnormal_fat_pad	0.68975882
79	MP0003279_aneurysm	0.68241226
80	MP0005503_abnormal_tendon_morphology	0.68179042
81	MP0002078_abnormal_glucose_homeostasis	0.68006686
82	MP0004130_abnormal_muscle_cell	0.66727723
83	MP0002108_abnormal_muscle_morphology	0.66311833
84	MP0002132_abnormal_respiratory_system	0.63910739
85	MP0005023_abnormal_wound_healing	0.63712136
86	MP0005165_increased_susceptibility_to	0.63468896
87	MP0001661_extended_life_span	0.62947088
88	MP0000681_abnormal_thyroid_gland	0.62694321
89	MP0004782_abnormal_surfactant_physiolog	0.62004992
90	MP0003183_abnormal_peptide_metabolism	0.61454968
91	MP0005666_abnormal_adipose_tissue	0.61293661
92	MP0000566_synostosis	0.60743752
93	MP0003879_abnormal_hair_cell	0.60611474
94	MP0000163_abnormal_cartilage_morphology	0.60485081
95	MP0006036_abnormal_mitochondrial_physio	0.60350787
96	MP0000639_abnormal_adrenal_gland	0.58697098
97	MP0009765_abnormal_xenobiotic_induced	0.58372374
98	MP0001756_abnormal_urination	0.55171214
99	MP0003690_abnormal_glial_cell	0.53930583
100	MP0003329_amyloid_beta_deposits	0.53925566
101	MP0001542_abnormal_bone_strength	0.53486966
102	MP0003724_increased_susceptibility_to	0.52451583
103	MP0002295_abnormal_pulmonary_circulatio	0.52423570
104	MP0009379_abnormal_foot_pigmentation	0.51732231
105	MP0005248_abnormal_Harderian_gland	0.50921266
106	MP0005266_abnormal_metabolism	0.50871611
107	MP0005395_other_phenotype	0.50460186
108	MP0005595_abnormal_vascular_smooth	0.47036226
109	MP0005448_abnormal_energy_balance	0.46353880
110	MP0009672_abnormal_birth_weight	0.45790212
111	MP0004272_abnormal_basement_membrane	0.45675014
112	MP0002876_abnormal_thyroid_physiology	0.44870297
113	MP0002168_other_aberrant_phenotype	0.44309386
114	MP0005535_abnormal_body_temperature	0.44150961
115	MP0009115_abnormal_fat_cell	0.43551896
116	MP0002928_abnormal_bile_duct	0.43129017
117	MP0002136_abnormal_kidney_physiology	0.42767694
118	MP0000249_abnormal_blood_vessel	0.42738710
119	MP0005164_abnormal_response_to	0.42331973
120	MP0003436_decreased_susceptibility_to	0.42110333
121	MP0003638_abnormal_response/metabolism_	0.41242867
122	MP0005464_abnormal_platelet_physiology	0.40057657
123	MP0003075_altered_response_to	0.39211520
124	MP0008873_increased_physiological_sensi	0.38812771
125	MP0002970_abnormal_white_adipose	0.37158186
126	MP0004883_abnormal_blood_vessel	0.37134674
127	MP0002796_impaired_skin_barrier	0.36623695
128	MP0002282_abnormal_trachea_morphology	0.36553694
129	MP0002837_dystrophic_cardiac_calcinosis	0.36241980
130	MP0000579_abnormal_nail_morphology	0.34094350
131	MP0002896_abnormal_bone_mineralization	0.33714554
132	MP0001915_intracranial_hemorrhage	0.33660856
133	MP0005166_decreased_susceptibility_to	0.33284750
134	MP0000767_abnormal_smooth_muscle	0.33211566
135	MP0001853_heart_inflammation	0.32676191

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	7.28635169
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.05194384
3	Intrahepatic cholestasis (HP:0001406)	6.96592416
4	Xanthomatosis (HP:0000991)	6.42139308
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.37116839
6	Prolonged partial thromboplastin time (HP:0003645)	6.11997381
7	Hypobetalipoproteinemia (HP:0003563)	5.95299483
8	Hyperlipoproteinemia (HP:0010980)	5.32073749
9	Complement deficiency (HP:0004431)	5.14491174
10	Hypolipoproteinemia (HP:0010981)	4.76278101
11	Hypoalphalipoproteinemia (HP:0003233)	4.45283926
12	Joint hemorrhage (HP:0005261)	4.42524756
13	Hyperammonemia (HP:0001987)	4.39369948
14	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.29729683
15	Abnormality of the common coagulation pathway (HP:0010990)	4.28336614
16	Epidermoid cyst (HP:0200040)	4.20283214
17	Hyperglycinemia (HP:0002154)	4.19859942
18	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.17243144
19	Ketosis (HP:0001946)	4.10467736
20	Abnormality of methionine metabolism (HP:0010901)	4.04881726
21	Abnormality of complement system (HP:0005339)	4.04829458
22	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.04449944
23	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.91342567
24	Abnormality of serine family amino acid metabolism (HP:0010894)	3.82705032
25	Abnormality of glycine metabolism (HP:0010895)	3.82705032
26	Fat malabsorption (HP:0002630)	3.82543782
27	Hyperglycinuria (HP:0003108)	3.77477132
28	Hypoglycemic coma (HP:0001325)	3.76566880
29	Abnormality of the intrinsic pathway (HP:0010989)	3.71972721
30	Vertebral compression fractures (HP:0002953)	3.60361852
31	Abnormality of pyrimidine metabolism (HP:0004353)	3.50171968
32	Myocardial infarction (HP:0001658)	3.41942617
33	Hypercholesterolemia (HP:0003124)	3.38446937
34	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.23117224
35	Conjugated hyperbilirubinemia (HP:0002908)	3.19762566
36	Abnormality of fatty-acid metabolism (HP:0004359)	3.18990480
37	Hyperbilirubinemia (HP:0002904)	3.13438839
38	Cervical subluxation (HP:0003308)	3.04586848
39	Hepatocellular carcinoma (HP:0001402)	2.98397239
40	Delayed CNS myelination (HP:0002188)	2.98146490
41	Abnormality of serum amino acid levels (HP:0003112)	2.92983729
42	Ketoacidosis (HP:0001993)	2.91941233
43	Skin nodule (HP:0200036)	2.87344683
44	Steatorrhea (HP:0002570)	2.84627972
45	Abnormality of nucleobase metabolism (HP:0010932)	2.81783981
46	Spontaneous abortion (HP:0005268)	2.70395173
47	Aortic dissection (HP:0002647)	2.68419595
48	Aortic aneurysm (HP:0004942)	2.68291620
49	Vascular calcification (HP:0004934)	2.66605265
50	Ankle contracture (HP:0006466)	2.65208202
51	Vascular tortuosity (HP:0004948)	2.63306679
52	Mitral stenosis (HP:0001718)	2.61242319
53	Nephritis (HP:0000123)	2.59995120
54	Cardiovascular calcification (HP:0011915)	2.56670563
55	Systemic lupus erythematosus (HP:0002725)	2.53266655
56	Abnormality of carpal bone ossification (HP:0006257)	2.51273986
57	Cerebral aneurysm (HP:0004944)	2.51157876
58	Blue sclerae (HP:0000592)	2.51009661
59	Metabolic acidosis (HP:0001942)	2.49975362
60	Abnormality of purine metabolism (HP:0004352)	2.47589988
61	Hypochromic microcytic anemia (HP:0004840)	2.47050732
62	Protrusio acetabuli (HP:0003179)	2.46546010
63	Mucopolysacchariduria (HP:0008155)	2.46444333
64	Urinary glycosaminoglycan excretion (HP:0003541)	2.46444333
65	Dicarboxylic aciduria (HP:0003215)	2.44181440
66	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.44181440
67	Abnormality of polysaccharide metabolism (HP:0011012)	2.42070024
68	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.42070024
69	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.42070024
70	Abnormal gallbladder morphology (HP:0012437)	2.36239438
71	Lethargy (HP:0001254)	2.36211961
72	Hypoglycemic seizures (HP:0002173)	2.35063102
73	Neonatal short-limb short stature (HP:0008921)	2.34807887
74	Spastic diplegia (HP:0001264)	2.33384166
75	Abnormal delivery (HP:0001787)	2.31687983
76	Cholelithiasis (HP:0001081)	2.30732928
77	Follicular hyperkeratosis (HP:0007502)	2.29878316
78	Wormian bones (HP:0002645)	2.29866231
79	Abnormality of the acetabulum (HP:0003170)	2.29388158
80	Amyloidosis (HP:0011034)	2.27488924
81	Acanthocytosis (HP:0001927)	2.26888644
82	Peritonitis (HP:0002586)	2.26339726
83	Arterial tortuosity (HP:0005116)	2.24417367
84	Soft skin (HP:0000977)	2.22846478
85	Achilles tendon contracture (HP:0001771)	2.22586265
86	Premature rupture of membranes (HP:0001788)	2.21958027
87	Coxa vara (HP:0002812)	2.21904804
88	Purpura (HP:0000979)	2.21770801
89	Glomerulonephritis (HP:0000099)	2.21577118
90	Broad metatarsal (HP:0001783)	2.21062503
91	Abnormal cartilage morphology (HP:0002763)	2.20840328
92	Dysostosis multiplex (HP:0000943)	2.20391153
93	Late onset (HP:0003584)	2.20092233
94	Neonatal onset (HP:0003623)	2.19902166
95	Abnormal gallbladder physiology (HP:0012438)	2.19158459
96	Cholecystitis (HP:0001082)	2.19158459
97	Fragile skin (HP:0001030)	2.18455315
98	Malnutrition (HP:0004395)	2.17711514
99	Menorrhagia (HP:0000132)	2.17188745
100	Spinal rigidity (HP:0003306)	2.16910751
101	Hydroxyprolinuria (HP:0003080)	2.15925617
102	Abnormality of proline metabolism (HP:0010907)	2.15925617
103	Joint stiffness (HP:0001387)	2.15059915
104	Gout (HP:0001997)	2.15021359
105	Polycythemia (HP:0001901)	2.14906113
106	Bladder diverticulum (HP:0000015)	2.13293641
107	Abnormality of the Achilles tendon (HP:0005109)	2.13244013
108	Enlarged kidneys (HP:0000105)	2.11902321
109	Irritability (HP:0000737)	2.09681341
110	Shallow orbits (HP:0000586)	2.08802976
111	Esophageal varix (HP:0002040)	2.08328667
112	Cerebral edema (HP:0002181)	2.07622992
113	Flat acetabular roof (HP:0003180)	2.05906081
114	Gingival bleeding (HP:0000225)	2.04327631
115	Pancreatitis (HP:0001733)	2.02928079
116	Back pain (HP:0003418)	2.02888450
117	Ulnar bowing (HP:0003031)	2.02340312
118	Aneurysm (HP:0002617)	2.02265138
119	Nonimmune hydrops fetalis (HP:0001790)	2.01661519
120	Opisthotonus (HP:0002179)	2.01063101
121	Sensorimotor neuropathy (HP:0007141)	1.99084333
122	Abnormal ossification of hand bones (HP:0005921)	1.97419320
123	Hypophosphatemic rickets (HP:0004912)	1.95138894
124	Increased variability in muscle fiber diameter (HP:0003557)	1.95128124
125	Abnormality of the gallbladder (HP:0005264)	1.92657089
126	Thrombophlebitis (HP:0004418)	1.92452058
127	Distal upper limb amyotrophy (HP:0007149)	1.92317451
128	Upper limb amyotrophy (HP:0009129)	1.92317451
129	Abnormality of iron homeostasis (HP:0011031)	1.92059194
130	Abnormality of dentin (HP:0010299)	1.91037025
131	Hemorrhage of the eye (HP:0011885)	1.90778842
132	Type 1 muscle fiber predominance (HP:0003803)	1.89357235
133	Hypertriglyceridemia (HP:0002155)	1.88988941
134	Recurrent gram-negative bacterial infections (HP:0005420)	1.88827594
135	Hyperinsulinemic hypoglycemia (HP:0000825)	1.88237395
136	Brushfield spots (HP:0001088)	1.87858898
137	Vomiting (HP:0002013)	1.87703533
138	J-shaped sella turcica (HP:0002680)	1.87698510
139	Rickets (HP:0002748)	1.86433962
140	Increased connective tissue (HP:0009025)	1.85816913
141	Abnormality of transition element cation homeostasis (HP:0011030)	1.85790632
142	Ovoid vertebral bodies (HP:0003300)	1.85680176
143	Biconcave vertebral bodies (HP:0004586)	1.84029917
144	Elbow flexion contracture (HP:0002987)	1.83262103
145	Generalized aminoaciduria (HP:0002909)	1.82849492
146	Hyperglycemia (HP:0003074)	1.82253701
147	Atrophic scars (HP:0001075)	1.82157985
148	Poikilocytosis (HP:0004447)	1.82018290
149	Mildly elevated creatine phosphokinase (HP:0008180)	1.81185901
150	Ectopia lentis (HP:0001083)	1.79447669
151	Dilatation of the ascending aorta (HP:0005111)	1.79269956
152	Slender build (HP:0001533)	1.78478702
153	Wrist flexion contracture (HP:0001239)	1.77260637
154	Abnormal hand bone ossification (HP:0010660)	1.76138081
155	Thin bony cortex (HP:0002753)	1.72906776
156	Abnormal tarsal ossification (HP:0008369)	1.71729662
157	Ileus (HP:0002595)	1.70814139
158	Stridor (HP:0010307)	1.70785340

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	6.40010497
2	ERN1	4.79942298
3	SIK1	4.52512379
4	TRIB3	3.80819418
5	FGFR4	3.77251979
6	PKN2	3.27954033
7	ERBB4	2.42823128
8	EPHA2	2.36584888
9	MYLK	2.22188359
10	LMTK2	2.15571189
11	TAOK3	2.13808851
12	INSRR	2.13557206
13	FLT3	2.13160682
14	LATS1	2.11337322
15	NEK9	2.10059778
16	MST1R	1.92661164
17	PTK6	1.75365677
18	MAPK11	1.69215164
19	PRPF4B	1.65199658
20	PIK3CG	1.63373801
21	ABL2	1.55173489
22	PAK4	1.47458502
23	MAP2K4	1.46356724
24	PRKD2	1.37154860
25	CDC42BPA	1.33889674
26	MAP3K10	1.32203388
27	AKT3	1.32136300
28	KDR	1.30899868
29	NTRK1	1.30445563
30	PDGFRA	1.30282361
31	DDR2	1.26768929
32	STK38L	1.25058073
33	MET	1.24394148
34	TYK2	1.20685770
35	PIM2	1.20624124
36	LATS2	1.20476056
37	TESK1	1.18120839
38	MAP3K3	1.17002744
39	SMG1	1.12916645
40	FRK	1.12264001
41	MAP2K3	1.11662550
42	TBK1	1.10600937
43	EEF2K	1.10158955
44	MAP3K6	1.04376312
45	PRKAA2	1.02588288
46	PTK2	1.01957609
47	ZAP70	1.00981997
48	ERBB2	0.99930160
49	EPHB1	0.96485111
50	BMX	0.96097675
51	DYRK1B	0.95822243
52	CDK6	0.94053650
53	MAPK4	0.91703347
54	PDGFRB	0.91084563
55	MAPKAPK3	0.90696196
56	MAP3K7	0.89729701
57	JAK2	0.89654683
58	MAP3K11	0.88880595
59	FGFR2	0.88036831
60	ARAF	0.87548870
61	EPHA3	0.87114522
62	EPHB2	0.85751615
63	MOS	0.84097674
64	NME2	0.83592705
65	STK38	0.82606411
66	CSK	0.82321830
67	RIPK1	0.80056372
68	KIT	0.79279591
69	TGFBR2	0.74822263
70	JAK1	0.72558312
71	MAPK12	0.71900186
72	FER	0.71707493
73	ILK	0.71453570
74	TTN	0.70396914
75	WNK4	0.69716454
76	JAK3	0.67742641
77	MAP3K1	0.66186170
78	PRKD3	0.64771018
79	GRK6	0.63775280
80	GRK5	0.62553341
81	DAPK2	0.61708257
82	TAOK2	0.61252615
83	CAMK1D	0.60642005
84	PRKCZ	0.60592651
85	RPS6KA2	0.59502933
86	LIMK1	0.59468830
87	GSK3A	0.59015419
88	TESK2	0.58130848
89	EIF2AK1	0.57544155
90	PAK2	0.57461818
91	MAP3K2	0.55798690
92	IRAK3	0.55798086
93	MTOR	0.55095838
94	PRKACG	0.54711140
95	TIE1	0.54581944
96	MAP3K13	0.53288829
97	STK3	0.53127126
98	RET	0.51796375
99	RPS6KC1	0.51507595
100	RPS6KL1	0.51507595
101	MAP2K1	0.51409228
102	PDK1	0.50484811
103	KSR2	0.48399614
104	ADRBK1	0.46389023
105	CAMK2G	0.45053829
106	SRC	0.43496294
107	PDPK1	0.42839709
108	PINK1	0.42183154
109	MAPK15	0.42051108
110	IGF1R	0.41805745
111	CDK8	0.41779421
112	MAPK7	0.41734983
113	CDK4	0.41465340
114	MAP3K5	0.41349675
115	PRKAA1	0.41143258
116	LRRK2	0.40871129
117	PDK2	0.40408321
118	PTK2B	0.38613048
119	RPS6KA6	0.37638623
120	FGFR3	0.37197874
121	DAPK3	0.37094044
122	PIK3CA	0.36998245
123	MAP3K14	0.36138314
124	FGFR1	0.36032321
125	ROCK1	0.35730843
126	IRAK2	0.34754347
127	PAK3	0.33947091
128	RPS6KA4	0.33446855
129	PBK	0.33265589
130	ICK	0.33107277
131	TRPM7	0.32538139
132	PRKG2	0.31381384
133	EGFR	0.30955308
134	TLK1	0.30197154
135	CSF1R	0.29021446
136	MAP2K2	0.28531553
137	ABL1	0.26790372
138	PRKD1	0.24989970
139	MAP3K8	0.24176723
140	PRKCQ	0.22276631
141	SGK3	0.21710683
142	MAP2K6	0.20670450
143	INSR	0.19075788

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.45660987
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.67334459
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.36359969
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.27285875
5	Arginine biosynthesis_Homo sapiens_hsa00220	3.03672433
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.78823938
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.65208785
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.64705079
9	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.64006298
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.58865757
11	Fatty acid degradation_Homo sapiens_hsa00071	2.57217243
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.39081214
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.27787667
14	Butanoate metabolism_Homo sapiens_hsa00650	2.05900670
15	Peroxisome_Homo sapiens_hsa04146	2.04627961
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.04564924
17	PPAR signaling pathway_Homo sapiens_hsa03320	1.92788907
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.90866714
19	Propanoate metabolism_Homo sapiens_hsa00640	1.88785008
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.88014850
21	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.86502331
22	Fatty acid metabolism_Homo sapiens_hsa01212	1.85262659
23	Histidine metabolism_Homo sapiens_hsa00340	1.81709549
24	Other glycan degradation_Homo sapiens_hsa00511	1.69733900
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.69590285
26	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.67441001
27	Caffeine metabolism_Homo sapiens_hsa00232	1.64435083
28	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.64107385
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.63916821
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.62975190
31	Retinol metabolism_Homo sapiens_hsa00830	1.62825011
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.56512682
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.54115065
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54040844
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.51941271
36	Phenylalanine metabolism_Homo sapiens_hsa00360	1.50094095
37	Bile secretion_Homo sapiens_hsa04976	1.46122494
38	Sulfur metabolism_Homo sapiens_hsa00920	1.44827551
39	Tyrosine metabolism_Homo sapiens_hsa00350	1.38767967
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.34547935
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.33456048
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29982349
43	Folate biosynthesis_Homo sapiens_hsa00790	1.27287992
44	Fatty acid elongation_Homo sapiens_hsa00062	1.24836075
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24186217
46	Steroid biosynthesis_Homo sapiens_hsa00100	1.22225868
47	Sulfur relay system_Homo sapiens_hsa04122	1.17831849
48	Carbon metabolism_Homo sapiens_hsa01200	1.15859090
49	Fat digestion and absorption_Homo sapiens_hsa04975	1.14720884
50	ABC transporters_Homo sapiens_hsa02010	1.06863871
51	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.06569322
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.04934200
53	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04446522
54	One carbon pool by folate_Homo sapiens_hsa00670	0.96863539
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92537510
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.92224169
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90701856
58	Lysine degradation_Homo sapiens_hsa00310	0.86722939
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.84425347
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.82621952
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82478498
62	Pertussis_Homo sapiens_hsa05133	0.81273182
63	Mineral absorption_Homo sapiens_hsa04978	0.74015906
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73184931
65	Glutathione metabolism_Homo sapiens_hsa00480	0.70112005
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63004064
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60970430
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.59393828
69	Focal adhesion_Homo sapiens_hsa04510	0.55478692
70	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.49486448
71	Metabolic pathways_Homo sapiens_hsa01100	0.44117233
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42705315
73	Lysosome_Homo sapiens_hsa04142	0.39511282
74	Prion diseases_Homo sapiens_hsa05020	0.36900770
75	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.35379996
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33978872
77	Galactose metabolism_Homo sapiens_hsa00052	0.33706320
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.27535743
79	Insulin resistance_Homo sapiens_hsa04931	0.26920672
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.25701240
81	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.22676123
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.18955277
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.17704641
84	African trypanosomiasis_Homo sapiens_hsa05143	0.17620443
85	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.15376896
86	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.14646401
87	Proteoglycans in cancer_Homo sapiens_hsa05205	0.14431489
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.13025249
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.09205585
90	AMPK signaling pathway_Homo sapiens_hsa04152	0.07854411
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.06129850
92	Bladder cancer_Homo sapiens_hsa05219	0.04628965
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.02887692
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.02321532
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.00211585
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.2122431
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1852611
98	Hepatitis C_Homo sapiens_hsa05160	-0.1793145
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1547091
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1314838
101	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	-0.1285155
102	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1263302
103	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1251620
104	Malaria_Homo sapiens_hsa05144	-0.0883224
105	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0701125
106	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0679368
107	Amoebiasis_Homo sapiens_hsa05146	-0.0679023
108	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0646087
109	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.0445370
110	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0415192
111	ECM-receptor interaction_Homo sapiens_hsa04512	-0.0281418
112	Protein digestion and absorption_Homo sapiens_hsa04974	-0.0201848

OAF

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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