OARD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.00583837
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.95969933
3DNA deamination (GO:0045006)4.85701258
4proteasome assembly (GO:0043248)4.80208869
5maturation of SSU-rRNA (GO:0030490)4.78419286
6viral transcription (GO:0019083)4.67588879
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64879982
8translational termination (GO:0006415)4.56550382
9ribosomal small subunit biogenesis (GO:0042274)4.37281759
10telomere maintenance via semi-conservative replication (GO:0032201)4.28291382
11ribosomal large subunit biogenesis (GO:0042273)4.22740843
12DNA strand elongation involved in DNA replication (GO:0006271)4.22635682
13translational elongation (GO:0006414)4.19306965
14synapsis (GO:0007129)4.12387865
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.10912422
16DNA strand elongation (GO:0022616)4.08852733
17cotranslational protein targeting to membrane (GO:0006613)4.04995100
18ATP synthesis coupled proton transport (GO:0015986)3.99879663
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99879663
20protein targeting to ER (GO:0045047)3.99477219
21CENP-A containing nucleosome assembly (GO:0034080)3.90706660
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85639943
23telomere maintenance via recombination (GO:0000722)3.82436401
24chaperone-mediated protein transport (GO:0072321)3.82078540
25protein localization to endoplasmic reticulum (GO:0070972)3.80197436
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79504651
27chromatin remodeling at centromere (GO:0031055)3.78744398
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.78289411
29formation of translation preinitiation complex (GO:0001731)3.77241340
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.75953708
31translational initiation (GO:0006413)3.73299772
32protein complex biogenesis (GO:0070271)3.70588135
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.68627087
34termination of RNA polymerase III transcription (GO:0006386)3.68338983
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.68338983
36ribonucleoprotein complex biogenesis (GO:0022613)3.65799704
37purine nucleobase biosynthetic process (GO:0009113)3.64123553
38DNA replication checkpoint (GO:0000076)3.63263117
39regulation of meiosis I (GO:0060631)3.62697350
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61082952
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.61082952
42NADH dehydrogenase complex assembly (GO:0010257)3.61082952
43viral life cycle (GO:0019058)3.60022842
44mitochondrial respiratory chain complex assembly (GO:0033108)3.59235458
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55213357
46nucleobase biosynthetic process (GO:0046112)3.54532269
47DNA replication initiation (GO:0006270)3.54170906
48mitotic recombination (GO:0006312)3.50826577
49cellular protein complex disassembly (GO:0043624)3.50251004
50centriole replication (GO:0007099)3.50222894
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49680334
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49338021
53translation (GO:0006412)3.43136660
54rRNA modification (GO:0000154)3.42469924
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41967520
56negative regulation of ligase activity (GO:0051352)3.41967520
577-methylguanosine mRNA capping (GO:0006370)3.41461832
58respiratory electron transport chain (GO:0022904)3.41308751
59resolution of meiotic recombination intermediates (GO:0000712)3.39641805
60telomere maintenance via telomere lengthening (GO:0010833)3.39548958
61protein deneddylation (GO:0000338)3.39424832
62establishment of integrated proviral latency (GO:0075713)3.37120412
63protein neddylation (GO:0045116)3.35787563
64electron transport chain (GO:0022900)3.35001441
65mitotic metaphase plate congression (GO:0007080)3.34362837
66RNA capping (GO:0036260)3.32595632
677-methylguanosine RNA capping (GO:0009452)3.32595632
68pseudouridine synthesis (GO:0001522)3.32407459
69epithelial cilium movement (GO:0003351)3.32181476
70transcription-coupled nucleotide-excision repair (GO:0006283)3.32040695
71rRNA processing (GO:0006364)3.30083634
72male meiosis I (GO:0007141)3.28368787
73DNA replication-independent nucleosome organization (GO:0034724)3.28349770
74DNA replication-independent nucleosome assembly (GO:0006336)3.28349770
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27537397
76regulation of cilium movement (GO:0003352)3.24350422
77cullin deneddylation (GO:0010388)3.24303237
78ribosome biogenesis (GO:0042254)3.24275115
79rRNA metabolic process (GO:0016072)3.23625903
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23226595
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23226595
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22712961
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22712961
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22712961
85regulation of cellular amino acid metabolic process (GO:0006521)3.20070107
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.19872626
87cellular component biogenesis (GO:0044085)3.19413699
88DNA double-strand break processing (GO:0000729)3.17056351
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.14153351
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14153351
91metaphase plate congression (GO:0051310)3.13284029
92inner mitochondrial membrane organization (GO:0007007)3.12196681
93water-soluble vitamin biosynthetic process (GO:0042364)3.12123862
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.11978601
95protein complex disassembly (GO:0043241)3.10808880
96regulation of mitochondrial translation (GO:0070129)3.10415004
97attachment of spindle microtubules to kinetochore (GO:0008608)3.10332629
98intraciliary transport (GO:0042073)3.09647808
99piRNA metabolic process (GO:0034587)3.08937036
100kinetochore organization (GO:0051383)3.08528925
101spliceosomal snRNP assembly (GO:0000387)3.07316246
102kinetochore assembly (GO:0051382)3.06275000
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04269378
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03107248
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02686462
106nuclear-transcribed mRNA catabolic process (GO:0000956)3.00894868
107metallo-sulfur cluster assembly (GO:0031163)3.00801516
108iron-sulfur cluster assembly (GO:0016226)3.00801516
109histone exchange (GO:0043486)3.00106717
110respiratory chain complex IV assembly (GO:0008535)2.98952992
111macromolecular complex disassembly (GO:0032984)2.97323836
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97140500
113DNA unwinding involved in DNA replication (GO:0006268)2.97090371
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96766528
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96766528
116ribosome assembly (GO:0042255)2.96371178
117meiosis I (GO:0007127)2.95530575
118positive regulation of ligase activity (GO:0051351)2.94645328
119oxidative phosphorylation (GO:0006119)2.90411771
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.88977720
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88977720
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88179726
123DNA ligation (GO:0006266)2.87702384
124maturation of 5.8S rRNA (GO:0000460)2.86355212
125rRNA methylation (GO:0031167)2.85956808
126GTP biosynthetic process (GO:0006183)2.85910162
127deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.85108821
128mRNA catabolic process (GO:0006402)2.84816745
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84611678
130meiotic chromosome segregation (GO:0045132)2.81980978
131DNA damage response, detection of DNA damage (GO:0042769)2.80027589
132regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79769560
133regulation of mitotic spindle checkpoint (GO:1903504)2.79769560
134cilium movement (GO:0003341)2.79481415
135reciprocal meiotic recombination (GO:0007131)2.75789442
136reciprocal DNA recombination (GO:0035825)2.75789442
137intracellular protein transmembrane import (GO:0044743)2.73973865
138DNA catabolic process, exonucleolytic (GO:0000738)2.69010912
139chromosome organization involved in meiosis (GO:0070192)2.67395729
140cytochrome complex assembly (GO:0017004)2.67006368
141regulation of DNA endoreduplication (GO:0032875)2.66452799
142positive regulation of histone H3-K4 methylation (GO:0051571)2.65202566
143establishment of viral latency (GO:0019043)2.64891614
144regulation of helicase activity (GO:0051095)2.62401044
145histone mRNA metabolic process (GO:0008334)2.60608047
146microtubule depolymerization (GO:0007019)2.60363155
147male meiosis (GO:0007140)2.59485375
148negative regulation of DNA-dependent DNA replication (GO:2000104)2.56749228
149spindle checkpoint (GO:0031577)2.56469008
150mitotic spindle checkpoint (GO:0071174)2.56398509
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.54276375
152negative regulation of sister chromatid segregation (GO:0033046)2.54276375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.53114945
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.26326830
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08337628
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.72638021
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.66072869
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57862863
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.47375211
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22620527
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.11140956
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06501410
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00452862
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.99504212
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94752950
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90566522
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80488430
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78388345
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71779982
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70285113
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.56566096
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45753884
21VDR_23849224_ChIP-Seq_CD4+_Human2.43171275
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39820704
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34864229
24ZNF274_21170338_ChIP-Seq_K562_Hela2.33952816
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33042972
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31506792
27XRN2_22483619_ChIP-Seq_HELA_Human2.28537442
28IGF1R_20145208_ChIP-Seq_DFB_Human2.28190646
29FOXP3_21729870_ChIP-Seq_TREG_Human2.21837447
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.12656408
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12574183
32SALL1_21062744_ChIP-ChIP_HESCs_Human2.08954891
33FUS_26573619_Chip-Seq_HEK293_Human2.06846367
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06529119
35DCP1A_22483619_ChIP-Seq_HELA_Human2.03012517
36EWS_26573619_Chip-Seq_HEK293_Human2.02531315
37GABP_19822575_ChIP-Seq_HepG2_Human1.97509727
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97229536
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96542226
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93222010
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92897353
42VDR_22108803_ChIP-Seq_LS180_Human1.91367597
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89379401
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85424643
45ELK1_19687146_ChIP-ChIP_HELA_Human1.84030616
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81587732
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81360834
48TTF2_22483619_ChIP-Seq_HELA_Human1.79169415
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77294233
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.76745325
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72805520
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72449736
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69634330
54TAF15_26573619_Chip-Seq_HEK293_Human1.69544289
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68596092
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64030198
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63669519
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61862136
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61037704
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60328968
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56102144
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53578121
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.53357839
64AR_21909140_ChIP-Seq_LNCAP_Human1.51517679
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43469983
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43322534
67P300_19829295_ChIP-Seq_ESCs_Human1.42708736
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.41912943
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41309872
70CIITA_25753668_ChIP-Seq_RAJI_Human1.36853192
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.35461178
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31684832
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31165427
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29739692
75KDM5A_27292631_Chip-Seq_BREAST_Human1.28145733
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26395229
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23195864
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22203393
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.22078100
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20586943
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20357245
82TP53_22573176_ChIP-Seq_HFKS_Human1.20233794
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19275774
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19132028
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18289988
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18092553
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16608416
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15398046
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14562362
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14102054
91IRF1_19129219_ChIP-ChIP_H3396_Human1.13087606
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12764231
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12174984
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09675890
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08263549
96ELK1_22589737_ChIP-Seq_MCF10A_Human1.07694577
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07028008
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04320264
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.03877634
100MYC_18940864_ChIP-ChIP_HL60_Human1.03661364
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.03063686
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01733186
103CBP_20019798_ChIP-Seq_JUKART_Human1.01233414
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01233414
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00331181
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99164189
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99144336
108GBX2_23144817_ChIP-Seq_PC3_Human0.95614804
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95535701
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95483585
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95296572
112SPI1_23547873_ChIP-Seq_NB4_Human0.95164663
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94869942
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93958598
115SOX2_19829295_ChIP-Seq_ESCs_Human0.93576880
116NANOG_19829295_ChIP-Seq_ESCs_Human0.93576880
117RNF2_27304074_Chip-Seq_NSC_Mouse0.93235787
118ER_23166858_ChIP-Seq_MCF-7_Human0.92467897
119HTT_18923047_ChIP-ChIP_STHdh_Human0.91574593
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91190279
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89440263
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88573744
123AR_20517297_ChIP-Seq_VCAP_Human0.88476104
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88305780
125GATA1_22025678_ChIP-Seq_K562_Human0.87992236
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87820425
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87435241
128FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86891533
129TFEB_21752829_ChIP-Seq_HELA_Human0.86178912
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85650027
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83787036
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83049964
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82193284
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78538148
135CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76644479
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75000744
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74607386
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73365975
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.72936918
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72526106
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72488857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.22316259
2MP0010094_abnormal_chromosome_stability4.11000360
3MP0004957_abnormal_blastocyst_morpholog3.82799107
4MP0003111_abnormal_nucleus_morphology3.72802875
5MP0008058_abnormal_DNA_repair3.72033582
6MP0003077_abnormal_cell_cycle3.66033944
7MP0003806_abnormal_nucleotide_metabolis3.32689476
8MP0008057_abnormal_DNA_replication3.02133513
9MP0006292_abnormal_olfactory_placode2.68036132
10MP0003186_abnormal_redox_activity2.54269568
11MP0008932_abnormal_embryonic_tissue2.37868653
12MP0008007_abnormal_cellular_replicative2.23273965
13MP0008877_abnormal_DNA_methylation2.08773505
14MP0003122_maternal_imprinting1.97268932
15MP0003718_maternal_effect1.89542402
16MP0003786_premature_aging1.84808433
17MP0009379_abnormal_foot_pigmentation1.81243336
18MP0006072_abnormal_retinal_apoptosis1.80229876
19MP0002132_abnormal_respiratory_system1.78581320
20MP0001984_abnormal_olfaction1.75454017
21MP0006036_abnormal_mitochondrial_physio1.73577804
22MP0002396_abnormal_hematopoietic_system1.70639476
23MP0008995_early_reproductive_senescence1.67485032
24MP0003787_abnormal_imprinting1.63375950
25MP0009697_abnormal_copulation1.62902425
26MP0004147_increased_porphyrin_level1.61437418
27MP0001730_embryonic_growth_arrest1.59910032
28MP0005075_abnormal_melanosome_morpholog1.59545225
29MP0000490_abnormal_crypts_of1.54262564
30MP0002837_dystrophic_cardiac_calcinosis1.54002143
31MP0000372_irregular_coat_pigmentation1.51301947
32MP0002102_abnormal_ear_morphology1.48567260
33MP0003195_calcinosis1.48272880
34MP0002638_abnormal_pupillary_reflex1.47992903
35MP0004133_heterotaxia1.47587377
36MP0000566_synostosis1.45890491
37MP0000631_abnormal_neuroendocrine_gland1.43957741
38MP0000313_abnormal_cell_death1.42313383
39MP0000350_abnormal_cell_proliferation1.40803990
40MP0001764_abnormal_homeostasis1.37990594
41MP0003763_abnormal_thymus_physiology1.36664648
42MP0005084_abnormal_gallbladder_morpholo1.36383822
43MP0003698_abnormal_male_reproductive1.35992242
44MP0006035_abnormal_mitochondrial_morpho1.34032111
45MP0001188_hyperpigmentation1.33675777
46MP0001986_abnormal_taste_sensitivity1.33447053
47MP0003880_abnormal_central_pattern1.32465499
48MP0001293_anophthalmia1.31180929
49MP0010030_abnormal_orbit_morphology1.31133699
50MP0009333_abnormal_splenocyte_physiolog1.27679285
51MP0005408_hypopigmentation1.26382794
52MP0003123_paternal_imprinting1.25704685
53MP0004142_abnormal_muscle_tone1.23676581
54MP0002019_abnormal_tumor_incidence1.22746097
55MP0008789_abnormal_olfactory_epithelium1.22282704
56MP0002210_abnormal_sex_determination1.22165511
57MP0002277_abnormal_respiratory_mucosa1.22062369
58MP0001697_abnormal_embryo_size1.21349025
59MP0005253_abnormal_eye_physiology1.20599294
60MP0001853_heart_inflammation1.18694998
61MP0005551_abnormal_eye_electrophysiolog1.18452259
62MP0005645_abnormal_hypothalamus_physiol1.17682650
63MP0001485_abnormal_pinna_reflex1.16806761
64MP0003315_abnormal_perineum_morphology1.15392173
65MP0005379_endocrine/exocrine_gland_phen1.14244435
66MP0003890_abnormal_embryonic-extraembry1.13039980
67MP0005248_abnormal_Harderian_gland1.10179160
68MP0001145_abnormal_male_reproductive1.08239060
69MP0002080_prenatal_lethality1.07690020
70MP0000703_abnormal_thymus_morphology1.06952580
71MP0002938_white_spotting1.05936255
72MP0001119_abnormal_female_reproductive1.05351997
73MP0000689_abnormal_spleen_morphology1.04722979
74MP0005410_abnormal_fertilization1.03484749
75MP0005389_reproductive_system_phenotype1.03223629
76MP0002722_abnormal_immune_system1.02089683
77MP0002160_abnormal_reproductive_system1.01549575
78MP0005377_hearing/vestibular/ear_phenot1.01332213
79MP0003878_abnormal_ear_physiology1.01332213
80MP0001929_abnormal_gametogenesis1.00481880
81MP0003937_abnormal_limbs/digits/tail_de1.00026421
82MP0001672_abnormal_embryogenesis/_devel0.99921964
83MP0005380_embryogenesis_phenotype0.99921964
84MP0004808_abnormal_hematopoietic_stem0.99557026
85MP0002398_abnormal_bone_marrow0.98037523
86MP0006276_abnormal_autonomic_nervous0.97996635
87MP0005174_abnormal_tail_pigmentation0.97331097
88MP0003567_abnormal_fetal_cardiomyocyte0.96463211
89MP0000653_abnormal_sex_gland0.94704195
90MP0002233_abnormal_nose_morphology0.94587645
91MP0004885_abnormal_endolymph0.94460269
92MP0003136_yellow_coat_color0.91492418
93MP0006054_spinal_hemorrhage0.90799633
94MP0001529_abnormal_vocalization0.88537926
95MP0002085_abnormal_embryonic_tissue0.88386804
96MP0008875_abnormal_xenobiotic_pharmacok0.87640312
97MP0002429_abnormal_blood_cell0.85836600
98MP0000358_abnormal_cell_content/0.84513492
99MP0003984_embryonic_growth_retardation0.84324896
100MP0002095_abnormal_skin_pigmentation0.84249039
101MP0003011_delayed_dark_adaptation0.83800067
102MP0000647_abnormal_sebaceous_gland0.82268989
103MP0002234_abnormal_pharynx_morphology0.82001392
104MP0001545_abnormal_hematopoietic_system0.81993548
105MP0005397_hematopoietic_system_phenotyp0.81993548
106MP0002161_abnormal_fertility/fecundity0.81825053
107MP0009785_altered_susceptibility_to0.80684204
108MP0002088_abnormal_embryonic_growth/wei0.80003947
109MP0005266_abnormal_metabolism0.79966923
110MP0001919_abnormal_reproductive_system0.79804425
111MP0005671_abnormal_response_to0.78573284
112MP0004215_abnormal_myocardial_fiber0.78557520
113MP0003121_genomic_imprinting0.77432220
114MP0000778_abnormal_nervous_system0.77389188
115MP0005391_vision/eye_phenotype0.76888121
116MP0000049_abnormal_middle_ear0.75475716
117MP0005332_abnormal_amino_acid0.73893204
118MP0003938_abnormal_ear_development0.73045391
119MP0005195_abnormal_posterior_eye0.72811677
120MP0002139_abnormal_hepatobiliary_system0.71135562
121MP0002090_abnormal_vision0.71123819
122MP0000716_abnormal_immune_system0.70859359
123MP0002086_abnormal_extraembryonic_tissu0.70175941
124MP0005646_abnormal_pituitary_gland0.69900997
125MP0000685_abnormal_immune_system0.69743511
126MP0005636_abnormal_mineral_homeostasis0.69104567
127MP0005085_abnormal_gallbladder_physiolo0.67470973
128MP0005365_abnormal_bile_salt0.67434091
129MP0002163_abnormal_gland_morphology0.67052622
130MP0002098_abnormal_vibrissa_morphology0.65570663
131MP0001835_abnormal_antigen_presentation0.64678130
132MP0002084_abnormal_developmental_patter0.64349605
133MP0005394_taste/olfaction_phenotype0.61043721
134MP0005499_abnormal_olfactory_system0.61043721
135MP0001286_abnormal_eye_development0.60911804
136MP0002751_abnormal_autonomic_nervous0.60882642
137MP0003119_abnormal_digestive_system0.60706738
138MP0002653_abnormal_ependyma_morphology0.59419101
139MP0005376_homeostasis/metabolism_phenot0.59297059
140MP0003943_abnormal_hepatobiliary_system0.58783959
141MP0004197_abnormal_fetal_growth/weight/0.58246031
142MP0005025_abnormal_response_to0.57029233
143MP0002420_abnormal_adaptive_immunity0.56545759

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.71778912
2Reticulocytopenia (HP:0001896)4.70140204
3Abnormal number of erythroid precursors (HP:0012131)4.22479934
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.16861677
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.16861677
6Birth length less than 3rd percentile (HP:0003561)3.82661998
7Aplastic anemia (HP:0001915)3.78440558
8Oral leukoplakia (HP:0002745)3.42080862
9Colon cancer (HP:0003003)3.26889354
10Abnormal mitochondria in muscle tissue (HP:0008316)3.26606053
11Macrocytic anemia (HP:0001972)3.18233501
12Hyperglycinemia (HP:0002154)3.17236385
13Hepatocellular necrosis (HP:0001404)3.14456386
14Abnormality of the labia minora (HP:0012880)3.09663722
15Hepatic necrosis (HP:0002605)3.09259987
16Acute necrotizing encephalopathy (HP:0006965)3.04848666
17Mitochondrial inheritance (HP:0001427)3.03497382
18Medial flaring of the eyebrow (HP:0010747)2.98456515
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89104742
20Type I transferrin isoform profile (HP:0003642)2.84063268
21Increased CSF lactate (HP:0002490)2.82872725
22Increased intramyocellular lipid droplets (HP:0012240)2.80349594
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78794480
24Cerebral hypomyelination (HP:0006808)2.78120859
25Chromsome breakage (HP:0040012)2.77448295
26Increased hepatocellular lipid droplets (HP:0006565)2.77350454
27Increased serum lactate (HP:0002151)2.77276173
28Lipid accumulation in hepatocytes (HP:0006561)2.73407678
29Microvesicular hepatic steatosis (HP:0001414)2.72339905
30Methylmalonic acidemia (HP:0002912)2.71810743
31Pallor (HP:0000980)2.71570230
32Molar tooth sign on MRI (HP:0002419)2.70765257
33Abnormality of midbrain morphology (HP:0002418)2.70765257
34Congenital primary aphakia (HP:0007707)2.68361232
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.68015469
36Acute encephalopathy (HP:0006846)2.67543422
37Rough bone trabeculation (HP:0100670)2.63329135
38Abnormal ciliary motility (HP:0012262)2.61062358
39Gait imbalance (HP:0002141)2.60262345
40Exertional dyspnea (HP:0002875)2.58891766
4111 pairs of ribs (HP:0000878)2.58247646
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55442810
43Abnormality of the preputium (HP:0100587)2.54999088
44Breast hypoplasia (HP:0003187)2.51907248
45Increased muscle lipid content (HP:0009058)2.51857035
46Nephronophthisis (HP:0000090)2.50318481
47Microretrognathia (HP:0000308)2.50277097
48Abnormal respiratory epithelium morphology (HP:0012253)2.45822588
49Abnormal respiratory motile cilium morphology (HP:0005938)2.45822588
503-Methylglutaconic aciduria (HP:0003535)2.45344337
51Meckel diverticulum (HP:0002245)2.45211111
52Nephrogenic diabetes insipidus (HP:0009806)2.44534600
53Absent thumb (HP:0009777)2.42583774
54Pancytopenia (HP:0001876)2.41066854
55Abnormal respiratory motile cilium physiology (HP:0012261)2.40273941
56Abnormality of chromosome stability (HP:0003220)2.39399042
57Increased serum pyruvate (HP:0003542)2.39145162
58Abnormality of glycolysis (HP:0004366)2.39145162
59Volvulus (HP:0002580)2.36466226
60Renal Fanconi syndrome (HP:0001994)2.35906523
61Abnormal lung lobation (HP:0002101)2.33359116
62Thrombocytosis (HP:0001894)2.30789403
63Abnormality of the ileum (HP:0001549)2.30725150
64Progressive macrocephaly (HP:0004481)2.30340060
65Septo-optic dysplasia (HP:0100842)2.30301136
66Stenosis of the external auditory canal (HP:0000402)2.29766558
67Myelodysplasia (HP:0002863)2.25785316
68Bone marrow hypocellularity (HP:0005528)2.25458991
69Pancreatic cysts (HP:0001737)2.25020099
70Hyperglycinuria (HP:0003108)2.23656878
71Exercise intolerance (HP:0003546)2.22952531
72Absent/shortened dynein arms (HP:0200106)2.22489679
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.22489679
74Methylmalonic aciduria (HP:0012120)2.20970273
75Asplenia (HP:0001746)2.20659406
76Degeneration of anterior horn cells (HP:0002398)2.19054820
77Abnormality of the anterior horn cell (HP:0006802)2.19054820
78Lactic acidosis (HP:0003128)2.18839435
79Pancreatic fibrosis (HP:0100732)2.18738359
80Supernumerary spleens (HP:0009799)2.17533056
81Abnormality of glycine metabolism (HP:0010895)2.17053831
82Abnormality of serine family amino acid metabolism (HP:0010894)2.17053831
83Abnormality of the renal collecting system (HP:0004742)2.16386836
84True hermaphroditism (HP:0010459)2.15605462
85Secondary amenorrhea (HP:0000869)2.15401212
86Abnormal protein glycosylation (HP:0012346)2.13883239
87Abnormal glycosylation (HP:0012345)2.13883239
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13883239
89Abnormal protein N-linked glycosylation (HP:0012347)2.13883239
90Genital tract atresia (HP:0001827)2.11346338
91Carpal bone hypoplasia (HP:0001498)2.11253542
92Premature graying of hair (HP:0002216)2.10023713
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.09976290
94Median cleft lip (HP:0000161)2.09973590
95IgM deficiency (HP:0002850)2.09170531
96Intestinal atresia (HP:0011100)2.07000478
97Abnormality of pyrimidine metabolism (HP:0004353)2.06933406
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06475079
99Medulloblastoma (HP:0002885)2.06023953
100Vaginal atresia (HP:0000148)2.05450876
101Triphalangeal thumb (HP:0001199)2.05249117
102Abnormality of the renal medulla (HP:0100957)2.03391171
103Duplicated collecting system (HP:0000081)2.02763783
104Abnormality of the heme biosynthetic pathway (HP:0010472)2.02472528
105Abnormality of urine glucose concentration (HP:0011016)2.02004926
106Glycosuria (HP:0003076)2.02004926
107Cellular immunodeficiency (HP:0005374)2.01656005
108Abnormality of renal resorption (HP:0011038)2.01500951
109Generalized aminoaciduria (HP:0002909)2.01126148
110Small intestinal stenosis (HP:0012848)2.00418297
111Duodenal stenosis (HP:0100867)2.00418297
112Respiratory difficulties (HP:0002880)2.00256482
113Cerebral edema (HP:0002181)1.99992262
114Agnosia (HP:0010524)1.99065544
115Type 2 muscle fiber atrophy (HP:0003554)1.98297602
116Abnormality of the duodenum (HP:0002246)1.97881417
117Poor head control (HP:0002421)1.97488578
118Lethargy (HP:0001254)1.97374024
119Patellar aplasia (HP:0006443)1.95295705
120Poor coordination (HP:0002370)1.95059654
121Ragged-red muscle fibers (HP:0003200)1.93887874
122Rhinitis (HP:0012384)1.92930309
123Aplasia/Hypoplasia of the spleen (HP:0010451)1.92565562
124Horseshoe kidney (HP:0000085)1.92200462
125Reduced antithrombin III activity (HP:0001976)1.92048871
126Sparse eyelashes (HP:0000653)1.91183318
127Sclerocornea (HP:0000647)1.90601387
128Optic disc pallor (HP:0000543)1.89567597
129Absent radius (HP:0003974)1.88805132
130Abnormal number of incisors (HP:0011064)1.88572028
131Abnormality of serum amino acid levels (HP:0003112)1.88306835
132Aplasia/Hypoplasia of the patella (HP:0006498)1.88224300
133Optic nerve coloboma (HP:0000588)1.88091481
134Oligodactyly (hands) (HP:0001180)1.87718488
135Congenital, generalized hypertrichosis (HP:0004540)1.86822658
136Sloping forehead (HP:0000340)1.86292388
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.84268841
138Respiratory failure (HP:0002878)1.84143102
139Male pseudohermaphroditism (HP:0000037)1.83208316
140CNS hypomyelination (HP:0003429)1.83052304
141Muscle fiber atrophy (HP:0100295)1.78720634
142Abnormality of vitamin B metabolism (HP:0004340)1.77930603
143Anencephaly (HP:0002323)1.77089026
144Postaxial foot polydactyly (HP:0001830)1.76661481
145Hyperphosphaturia (HP:0003109)1.76257983
146Bile duct proliferation (HP:0001408)1.75895087
147Abnormal biliary tract physiology (HP:0012439)1.75895087
148Leukodystrophy (HP:0002415)1.75439465
149Short tibia (HP:0005736)1.75424825
150Abnormality of methionine metabolism (HP:0010901)1.74482815
151Preaxial hand polydactyly (HP:0001177)1.72561659
152Postaxial hand polydactyly (HP:0001162)1.72060047
153Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71536272
154Tubulointerstitial nephritis (HP:0001970)1.69903533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.13281806
2WEE13.93992803
3SRPK13.64179395
4NME23.20263445
5PLK43.08787067
6STK163.04004836
7VRK22.85411406
8CDC72.69406781
9VRK12.43605721
10BRSK22.43300705
11TNIK2.36275794
12EIF2AK12.22415719
13BMPR1B2.11314830
14EIF2AK32.08656275
15TLK12.08199940
16ACVR1B2.01926028
17MAP3K42.00663236
18PASK1.99440391
19TRIM281.89993436
20DYRK31.89782921
21NUAK11.77078548
22MKNK11.75460065
23TSSK61.72263368
24TTK1.70722674
25NEK21.69553745
26BCKDK1.68546216
27PLK11.63738965
28TGFBR11.56743769
29AURKB1.41811718
30TESK21.36949306
31MAP2K71.35786188
32FRK1.32933023
33PBK1.32821567
34ATR1.30371742
35AURKA1.29517690
36BTK1.28422160
37MAP4K21.26343118
38PLK31.24507185
39ZAK1.24465157
40BRSK11.19609239
41RPS6KB21.17617102
42CCNB11.16190493
43CASK1.15131631
44MKNK21.10135016
45CDK71.08235053
46MST41.04966722
47TAF11.03814377
48CHEK21.03484280
49MUSK1.01829919
50INSRR1.01762450
51CSNK1G21.00423238
52CDK191.00247256
53BRAF0.98080069
54NEK10.93508809
55BCR0.92716547
56CSNK1G30.90884840
57STK30.89752204
58KDR0.89590426
59FLT30.88720994
60STK390.88534833
61DYRK20.87846420
62MAP3K80.87292724
63EIF2AK20.83507732
64STK40.82300733
65PLK20.81970548
66CDK30.81855058
67IRAK40.81571115
68PIM10.81302306
69IRAK30.80522758
70STK100.79293811
71RPS6KA40.78662839
72CSNK1G10.78546661
73CSNK2A10.78267498
74PDK20.76651182
75TIE10.75198348
76ADRBK20.74905475
77NME10.71800086
78CSNK2A20.70541282
79CDK80.70185672
80OXSR10.69788266
81STK240.69066987
82TEC0.68305675
83PRKCI0.66024894
84PRKCG0.65547660
85EPHA40.65268816
86PINK10.64484873
87CHEK10.63409579
88EPHA20.62850060
89WNK40.62720172
90PNCK0.62678106
91RPS6KA50.60612566
92CSNK1A1L0.59846793
93ATM0.59452483
94CDK40.58804695
95PAK10.56143893
96CSNK1E0.52964816
97ZAP700.52548293
98MELK0.51591048
99JAK30.51481728
100MAPK150.50905775
101OBSCN0.50892686
102YES10.50158675
103MAP3K110.49650579
104MAP2K60.49400660
105MYLK0.48726687
106GRK10.48185313
107MAPK130.47492069
108CSF1R0.47448083
109CDK20.46352279
110LYN0.46098934
111PIM20.45676420
112MAP4K10.45074233
113MAP3K120.45064266
114TESK10.44905943
115PAK40.43004753
116WNK30.42979464
117KIT0.42386775
118SYK0.41304696
119UHMK10.41298443
120MST1R0.40989582
121STK38L0.38639668
122NTRK30.38128612
123BRD40.37493209
124PRKCE0.36494877
125AKT30.36069179
126FGFR20.35878547
127PRKACB0.35747853
128DAPK10.33602273
129ERBB30.33014871
130CSNK1A10.32669994
131TXK0.31509365
132PRKACA0.31202232
133CDK10.29701671
134PRKG10.29200296
135MAPK40.28867204
136ABL20.27505435
137IKBKB0.27470088
138NLK0.26878286
139BLK0.26470933
140LRRK20.26169302

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.38436379
2DNA replication_Homo sapiens_hsa030304.20969452
3Proteasome_Homo sapiens_hsa030503.94186798
4Mismatch repair_Homo sapiens_hsa034303.80825876
5RNA polymerase_Homo sapiens_hsa030203.72460433
6Spliceosome_Homo sapiens_hsa030402.94782488
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71747398
8Homologous recombination_Homo sapiens_hsa034402.71151304
9Pyrimidine metabolism_Homo sapiens_hsa002402.70817336
10Base excision repair_Homo sapiens_hsa034102.61723921
11Nucleotide excision repair_Homo sapiens_hsa034202.49266779
12RNA transport_Homo sapiens_hsa030132.19155256
13Non-homologous end-joining_Homo sapiens_hsa034502.04187743
14Protein export_Homo sapiens_hsa030602.03680948
15Basal transcription factors_Homo sapiens_hsa030221.95839361
16Fanconi anemia pathway_Homo sapiens_hsa034601.83569464
17Cell cycle_Homo sapiens_hsa041101.82541948
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79970072
19One carbon pool by folate_Homo sapiens_hsa006701.78349112
20RNA degradation_Homo sapiens_hsa030181.64490621
21Oxidative phosphorylation_Homo sapiens_hsa001901.60590030
22Purine metabolism_Homo sapiens_hsa002301.58221496
23Parkinsons disease_Homo sapiens_hsa050121.57890786
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45377892
25Huntingtons disease_Homo sapiens_hsa050161.39453207
26Butanoate metabolism_Homo sapiens_hsa006501.36496515
27Cardiac muscle contraction_Homo sapiens_hsa042601.32734831
28Folate biosynthesis_Homo sapiens_hsa007901.32283786
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30651435
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.29267896
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22450086
32Glutathione metabolism_Homo sapiens_hsa004801.15209616
33Steroid biosynthesis_Homo sapiens_hsa001001.08941702
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07752955
35Caffeine metabolism_Homo sapiens_hsa002321.05566113
36p53 signaling pathway_Homo sapiens_hsa041151.05028628
37Sulfur relay system_Homo sapiens_hsa041220.98551480
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97881747
39mRNA surveillance pathway_Homo sapiens_hsa030150.94808237
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.94236320
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92906332
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92042717
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89856028
44Epstein-Barr virus infection_Homo sapiens_hsa051690.85500449
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.85001170
46Vitamin B6 metabolism_Homo sapiens_hsa007500.84940546
47Pentose phosphate pathway_Homo sapiens_hsa000300.84194943
48Phototransduction_Homo sapiens_hsa047440.82881285
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81099532
50Alzheimers disease_Homo sapiens_hsa050100.79878347
51Tryptophan metabolism_Homo sapiens_hsa003800.79377628
52Selenocompound metabolism_Homo sapiens_hsa004500.76419242
53Systemic lupus erythematosus_Homo sapiens_hsa053220.75154390
54Biosynthesis of amino acids_Homo sapiens_hsa012300.74922850
55Collecting duct acid secretion_Homo sapiens_hsa049660.73940031
56Fatty acid elongation_Homo sapiens_hsa000620.72286287
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71943610
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71175934
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71137120
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69726112
61Arachidonic acid metabolism_Homo sapiens_hsa005900.69114122
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.67711982
63Metabolic pathways_Homo sapiens_hsa011000.67060123
64Carbon metabolism_Homo sapiens_hsa012000.63915242
65Chemical carcinogenesis_Homo sapiens_hsa052040.62832620
66Primary immunodeficiency_Homo sapiens_hsa053400.62354437
67Sulfur metabolism_Homo sapiens_hsa009200.60605219
68Peroxisome_Homo sapiens_hsa041460.58070095
69Herpes simplex infection_Homo sapiens_hsa051680.56720980
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56018218
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55234663
72Pyruvate metabolism_Homo sapiens_hsa006200.54407453
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54215820
74Fatty acid metabolism_Homo sapiens_hsa012120.53300894
75Galactose metabolism_Homo sapiens_hsa000520.51879271
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51157804
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50928969
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50827454
79Nitrogen metabolism_Homo sapiens_hsa009100.49769891
80Circadian rhythm_Homo sapiens_hsa047100.48690668
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46448874
82Linoleic acid metabolism_Homo sapiens_hsa005910.46212311
83Basal cell carcinoma_Homo sapiens_hsa052170.44941538
84Fructose and mannose metabolism_Homo sapiens_hsa000510.43973877
85Antigen processing and presentation_Homo sapiens_hsa046120.43329102
86Other glycan degradation_Homo sapiens_hsa005110.42629827
87Histidine metabolism_Homo sapiens_hsa003400.42580644
88Retinol metabolism_Homo sapiens_hsa008300.42515994
89Nicotine addiction_Homo sapiens_hsa050330.42132890
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41831910
91Propanoate metabolism_Homo sapiens_hsa006400.41183134
92Starch and sucrose metabolism_Homo sapiens_hsa005000.40125323
93Arginine and proline metabolism_Homo sapiens_hsa003300.39434807
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39112568
95beta-Alanine metabolism_Homo sapiens_hsa004100.38048862
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37796958
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36116044
98Oocyte meiosis_Homo sapiens_hsa041140.33487862
99Taste transduction_Homo sapiens_hsa047420.31687914
100Tyrosine metabolism_Homo sapiens_hsa003500.31455921
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30720307
102Hedgehog signaling pathway_Homo sapiens_hsa043400.30582710
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29983095
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28257130
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.28205145
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27725679
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27404361
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27171651
109Viral carcinogenesis_Homo sapiens_hsa052030.26375074
110Fat digestion and absorption_Homo sapiens_hsa049750.26227268
111Olfactory transduction_Homo sapiens_hsa047400.25965924
112N-Glycan biosynthesis_Homo sapiens_hsa005100.23166741
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20840737
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20334219
115Regulation of autophagy_Homo sapiens_hsa041400.20328581
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.20077448
117Fatty acid degradation_Homo sapiens_hsa000710.18403205
118Phenylalanine metabolism_Homo sapiens_hsa003600.17729608
119HTLV-I infection_Homo sapiens_hsa051660.17352013
120Vitamin digestion and absorption_Homo sapiens_hsa049770.17324961
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.16710517

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