OAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* type I interferon signaling pathway (GO:0060337)6.66716657
2* cellular response to type I interferon (GO:0071357)6.66716657
3* response to type I interferon (GO:0034340)6.60825663
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.49883895
5antigen processing and presentation of endogenous antigen (GO:0019883)5.45210747
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.27118468
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.14655063
8immunoglobulin mediated immune response (GO:0016064)5.00086426
9positive regulation of gamma-delta T cell activation (GO:0046645)4.97362861
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93803810
11negative regulation of cell killing (GO:0031342)4.93803810
12positive regulation by symbiont of host defense response (GO:0052509)4.87447126
13modulation by symbiont of host defense response (GO:0052031)4.87447126
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.87447126
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.87447126
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.87447126
17modulation by symbiont of host immune response (GO:0052553)4.87447126
18* response to interferon-alpha (GO:0035455)4.69314552
19response to interferon-beta (GO:0035456)4.66113546
20* interferon-gamma-mediated signaling pathway (GO:0060333)4.60960223
21* negative regulation of viral genome replication (GO:0045071)4.59801143
22macrophage activation involved in immune response (GO:0002281)4.46134993
23regulation of interferon-alpha production (GO:0032647)4.37855220
24detection of other organism (GO:0098543)4.37571187
25positive regulation of interferon-alpha production (GO:0032727)4.37530147
26detection of bacterium (GO:0016045)4.33068952
27response to peptidoglycan (GO:0032494)4.27998736
28regulation of interferon-beta biosynthetic process (GO:0045357)4.22108161
29negative regulation of interleukin-12 production (GO:0032695)4.19527906
30B cell mediated immunity (GO:0019724)3.96511832
31neutrophil activation involved in immune response (GO:0002283)3.79834123
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.77375487
33positive regulation of type 2 immune response (GO:0002830)3.77374110
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.76214019
35response to host immune response (GO:0052572)3.76214019
36regulation of B cell receptor signaling pathway (GO:0050855)3.71822706
37detection of external biotic stimulus (GO:0098581)3.68513554
38T cell migration (GO:0072678)3.66608509
39regulation of type I interferon-mediated signaling pathway (GO:0060338)3.64649653
40regulation of gamma-delta T cell activation (GO:0046643)3.56576780
41negative regulation of T cell mediated immunity (GO:0002710)3.56105846
42cellular response to interferon-beta (GO:0035458)3.53895725
43positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.52600474
44* cellular response to interferon-gamma (GO:0071346)3.52414486
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.47124095
46* defense response to virus (GO:0051607)3.46292014
47detection of molecule of bacterial origin (GO:0032490)3.44532105
48response to host (GO:0075136)3.44240649
49response to host defenses (GO:0052200)3.44240649
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.44240649
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43531231
52regulation of antigen processing and presentation (GO:0002577)3.40542059
53positive regulation of antigen processing and presentation (GO:0002579)3.40481463
54negative regulation of lymphocyte mediated immunity (GO:0002707)3.37456760
55defense response to protozoan (GO:0042832)3.36330549
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.35476285
57* response to interferon-gamma (GO:0034341)3.34482939
58positive regulation of interferon-beta production (GO:0032728)3.34235829
59cellular response to exogenous dsRNA (GO:0071360)3.32932585
60NIK/NF-kappaB signaling (GO:0038061)3.25242207
61regulation of T cell tolerance induction (GO:0002664)3.24100138
62negative regulation of cytokine production involved in immune response (GO:0002719)3.23300392
63regulation of type 2 immune response (GO:0002828)3.22133689
64detection of biotic stimulus (GO:0009595)3.19267681
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17526339
66microglial cell activation (GO:0001774)3.16706024
67* regulation of viral genome replication (GO:0045069)3.15811307
68germinal center formation (GO:0002467)3.13888457
69T-helper 1 type immune response (GO:0042088)3.13340733
70negative regulation of leukocyte mediated immunity (GO:0002704)3.12798675
71regulation of T-helper 1 cell differentiation (GO:0045625)3.12227752
72response to protozoan (GO:0001562)3.12221284
73negative regulation of innate immune response (GO:0045824)3.11692614
74cellular response to virus (GO:0098586)3.10748985
75myeloid cell activation involved in immune response (GO:0002275)3.10396852
76myeloid dendritic cell differentiation (GO:0043011)3.06750706
77positive regulation of toll-like receptor signaling pathway (GO:0034123)3.02377350
78* negative regulation of viral process (GO:0048525)3.02374676
79regulation of MHC class I biosynthetic process (GO:0045343)3.01730667
80leukocyte aggregation (GO:0070486)3.00102782
81regulation of T cell mediated cytotoxicity (GO:0001914)2.98081158
82* cellular response to interferon-alpha (GO:0035457)2.97635713
83B cell receptor signaling pathway (GO:0050853)2.95534414
84regulation of tolerance induction (GO:0002643)2.95409400
85interferon-gamma secretion (GO:0072643)2.94414235
86myeloid dendritic cell activation (GO:0001773)2.92793587
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90943588
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89751724
89response to interleukin-15 (GO:0070672)2.89750432
90regulation of interferon-beta production (GO:0032648)2.89302319
91neutrophil activation (GO:0042119)2.88582387
92negative thymic T cell selection (GO:0045060)2.88290464
93respiratory burst (GO:0045730)2.87685445
94antigen processing and presentation via MHC class Ib (GO:0002475)2.87577071
95lymphocyte chemotaxis (GO:0048247)2.86099785
96macrophage activation (GO:0042116)2.83787685
97response to muramyl dipeptide (GO:0032495)2.83122079
98granulocyte activation (GO:0036230)2.82102096
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81648921
100regulation of interleukin-12 production (GO:0032655)2.81354831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human8.43125377
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.70750744
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.05661000
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.24615514
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.20916672
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53808676
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.28138876
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24938263
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02616807
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97573689
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.84734765
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70058616
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67982605
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57428636
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53464157
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34772721
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32853731
18* SPI1_23547873_ChIP-Seq_NB4_Human2.23774937
19MYB_26560356_Chip-Seq_TH2_Human2.18123279
20VDR_24763502_ChIP-Seq_THP-1_Human2.14529054
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.13795834
22MAF_26560356_Chip-Seq_TH1_Human2.13481737
23VDR_21846776_ChIP-Seq_THP-1_Human2.10562010
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05340705
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03011016
26RUNX_20019798_ChIP-Seq_JUKART_Human2.02155848
27SPI1_23127762_ChIP-Seq_K562_Human1.94705418
28GATA1_22025678_ChIP-Seq_K562_Human1.91403632
29MYB_26560356_Chip-Seq_TH1_Human1.84409816
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84407116
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.78068805
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76222838
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75271273
34MYC_22102868_ChIP-Seq_BL_Human1.70461668
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65269351
36UTX_26944678_Chip-Seq_JUKART_Human1.63887677
37* SMAD_19615063_ChIP-ChIP_OVARY_Human1.63111806
38VDR_24787735_ChIP-Seq_THP-1_Human1.60576608
39SCL_19346495_ChIP-Seq_HPC-7_Human1.54327530
40MAF_26560356_Chip-Seq_TH2_Human1.48913369
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48380791
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48109874
43* GATA3_27048872_Chip-Seq_THYMUS_Human1.47944384
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40957550
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40135651
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39213732
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38382411
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32943669
49* GATA3_26560356_Chip-Seq_TH2_Human1.32899838
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32316377
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32098242
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31158239
53TCF7_22412390_ChIP-Seq_EML_Mouse1.27900112
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27057187
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26348870
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23560981
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19775473
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18600076
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.18289735
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17743172
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15761521
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15477481
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14348580
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13825344
65LXR_22292898_ChIP-Seq_THP-1_Human1.13087975
66KDM2B_26808549_Chip-Seq_DND41_Human1.11806432
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.10605316
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10387410
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.09989364
70PU_27001747_Chip-Seq_BMDM_Mouse1.09166116
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08355001
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08110438
73BCL6_27268052_Chip-Seq_Bcells_Human1.06837561
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.06483680
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04896401
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01143671
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00154442
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98655734
79ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98470857
80PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98418373
81BCOR_27268052_Chip-Seq_Bcells_Human0.96461186
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96261110
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93514412
84GATA1_19941826_ChIP-Seq_K562_Human0.90102957
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89863728
86PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89165075
87RXR_22158963_ChIP-Seq_LIVER_Mouse0.84486928
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84109081
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83953564
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83899998
91STAT1_20625510_ChIP-Seq_HELA_Human0.82796286
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79237592
93IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78874124
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76000960
95EGR1_19032775_ChIP-ChIP_M12_Human0.74971691
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.74890496
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71199155
98RACK7_27058665_Chip-Seq_MCF-7_Human0.71026961
99CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69047296
100CTCF_26484167_Chip-Seq_Bcells_Mouse0.68089402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.59480157
2MP0001835_abnormal_antigen_presentation4.55634227
3MP0003303_peritoneal_inflammation4.01781490
4MP0009785_altered_susceptibility_to3.72059237
5MP0003436_decreased_susceptibility_to3.57186923
6MP0005671_abnormal_response_to3.31992185
7MP0001790_abnormal_immune_system3.25450493
8MP0005387_immune_system_phenotype3.25450493
9MP0006082_CNS_inflammation3.24814792
10MP0005000_abnormal_immune_tolerance3.12021330
11MP0001800_abnormal_humoral_immune3.10403578
12MP0005025_abnormal_response_to3.05913462
13MP0000685_abnormal_immune_system3.05429026
14MP0002148_abnormal_hypersensitivity_rea2.97060428
15MP0002419_abnormal_innate_immunity2.77785821
16MP0002723_abnormal_immune_serum2.72239696
17MP0002452_abnormal_antigen_presenting2.67520673
18MP0002420_abnormal_adaptive_immunity2.39741909
19MP0001819_abnormal_immune_cell2.39268845
20MP0003300_gastrointestinal_ulcer2.27676612
21MP0010155_abnormal_intestine_physiology2.21794548
22MP0001533_abnormal_skeleton_physiology2.00171713
23MP0001845_abnormal_inflammatory_respons1.98421709
24MP0009333_abnormal_splenocyte_physiolog1.91064059
25MP0003763_abnormal_thymus_physiology1.90575731
26MP0003191_abnormal_cellular_cholesterol1.89087387
27MP0004947_skin_inflammation1.83584059
28MP0000716_abnormal_immune_system1.82570510
29MP0009764_decreased_sensitivity_to1.78826112
30MP0002405_respiratory_system_inflammati1.77906471
31MP0008469_abnormal_protein_level1.76727533
32MP0002398_abnormal_bone_marrow1.73593433
33MP0004510_myositis1.63206810
34MP0002166_altered_tumor_susceptibility1.62533331
35MP0005464_abnormal_platelet_physiology1.59437368
36MP0003183_abnormal_peptide_metabolism1.51649076
37MP0005310_abnormal_salivary_gland1.51052608
38MP0005058_abnormal_lysosome_morphology1.50558290
39MP0003075_altered_response_to1.46646703
40MP0005451_abnormal_body_composition1.45311949
41MP0003866_abnormal_defecation1.44861202
42MP0002429_abnormal_blood_cell1.43091719
43MP0000689_abnormal_spleen_morphology1.42683006
44MP0002722_abnormal_immune_system1.34295556
45MP0000858_altered_metastatic_potential1.34278604
46MP0000343_altered_response_to1.33439061
47MP0002138_abnormal_hepatobiliary_system1.33148474
48MP0003806_abnormal_nucleotide_metabolis1.32201844
49MP0002139_abnormal_hepatobiliary_system1.31957372
50MP0000465_gastrointestinal_hemorrhage1.31419204
51MP0009840_abnormal_foam_cell1.30560956
52MP0005166_decreased_susceptibility_to1.27370690
53MP0001853_heart_inflammation1.25952833
54MP0003172_abnormal_lysosome_physiology1.22611226
55MP0008260_abnormal_autophagy1.21501947
56MP0009278_abnormal_bone_marrow1.20732581
57MP0002006_tumorigenesis1.19921607
58MP0001873_stomach_inflammation1.17624746
59MP0002998_abnormal_bone_remodeling1.16961097
60MP0009763_increased_sensitivity_to1.07361727
61MP0003448_altered_tumor_morphology1.05664667
62MP0005397_hematopoietic_system_phenotyp1.03117552
63MP0001545_abnormal_hematopoietic_system1.03117552
64MP0004883_abnormal_blood_vessel1.02286694
65MP0002277_abnormal_respiratory_mucosa1.01061616
66MP0000703_abnormal_thymus_morphology0.99668778
67MP0002132_abnormal_respiratory_system0.98959459
68MP0005164_abnormal_response_to0.96687764
69MP0000604_amyloidosis0.94624728
70MP0003045_fibrosis0.93279982
71MP0001663_abnormal_digestive_system0.90600828
72MP0003690_abnormal_glial_cell0.87926606
73MP0003828_pulmonary_edema0.84994513
74MP0008004_abnormal_stomach_pH0.84189979
75MP0005390_skeleton_phenotype0.80963915
76MP0002332_abnormal_exercise_endurance0.80649472
77MP0003453_abnormal_keratinocyte_physiol0.76523243
78MP0001851_eye_inflammation0.75745505
79MP0002933_joint_inflammation0.75358538
80MP0000490_abnormal_crypts_of0.74911778
81MP0002396_abnormal_hematopoietic_system0.69926351
82MP0008874_decreased_physiological_sensi0.69498836
83MP0009765_abnormal_xenobiotic_induced0.68369505
84MP0004808_abnormal_hematopoietic_stem0.66816267
85MP0000249_abnormal_blood_vessel0.66081181
86MP0004381_abnormal_hair_follicle0.66072054
87MP0003091_abnormal_cell_migration0.65867944
88MP0000609_abnormal_liver_physiology0.65462578
89MP0005319_abnormal_enzyme/_coenzyme0.61422741
90MP0003795_abnormal_bone_structure0.60899725
91MP0003656_abnormal_erythrocyte_physiolo0.59236360
92MP0002693_abnormal_pancreas_physiology0.58502489
93MP0005165_increased_susceptibility_to0.57518505
94MP0002254_reproductive_system_inflammat0.54949937
95MP0006054_spinal_hemorrhage0.52499292
96MP0002136_abnormal_kidney_physiology0.52058726
97MP0005381_digestive/alimentary_phenotyp0.51715920
98MP0005584_abnormal_enzyme/coenzyme_acti0.50923341
99MP0000920_abnormal_myelination0.50121255
100MP0003252_abnormal_bile_duct0.47304700

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.73362122
2Orchitis (HP:0100796)5.19454673
3Optic neuritis (HP:0100653)5.11896978
4Retrobulbar optic neuritis (HP:0100654)5.11896978
5Myositis (HP:0100614)5.11068799
6Recurrent bacterial skin infections (HP:0005406)5.10020985
7Recurrent abscess formation (HP:0002722)4.94665908
8Abnormality of macrophages (HP:0004311)4.88880740
9Elevated erythrocyte sedimentation rate (HP:0003565)4.38700091
10Mediastinal lymphadenopathy (HP:0100721)4.29155036
11Recurrent fungal infections (HP:0002841)4.09184466
12Recurrent gram-negative bacterial infections (HP:0005420)4.07196671
13Vasculitis (HP:0002633)4.03531195
14Meningitis (HP:0001287)4.01859201
15Recurrent cutaneous fungal infections (HP:0011370)3.94291008
16Chronic mucocutaneous candidiasis (HP:0002728)3.94291008
17Stomatitis (HP:0010280)3.90308131
18Gastrointestinal infarctions (HP:0005244)3.82150967
19Recurrent skin infections (HP:0001581)3.73505741
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.72221802
21Keratoconjunctivitis sicca (HP:0001097)3.60875725
22Recurrent viral infections (HP:0004429)3.60435427
23Pulmonary infiltrates (HP:0002113)3.56800975
24Increased IgM level (HP:0003496)3.51797086
25Encephalitis (HP:0002383)3.44118979
26Obstructive lung disease (HP:0006536)3.39989470
27Chronic obstructive pulmonary disease (HP:0006510)3.39989470
28Keratoconjunctivitis (HP:0001096)3.34916833
29Hemoptysis (HP:0002105)3.33779723
30Increased IgE level (HP:0003212)3.28233269
31Urticaria (HP:0001025)3.26841494
32Systemic lupus erythematosus (HP:0002725)3.21029543
33Recurrent bronchitis (HP:0002837)3.16602985
34Gingivitis (HP:0000230)3.12453336
35Abnormality of glycolipid metabolism (HP:0010969)3.11962006
36Abnormality of liposaccharide metabolism (HP:0010968)3.11962006
37Abnormality of glycosphingolipid metabolism (HP:0004343)3.11962006
38Agammaglobulinemia (HP:0004432)3.03334409
39Cellulitis (HP:0100658)2.96748178
40Chronic otitis media (HP:0000389)2.94891459
41Loss of speech (HP:0002371)2.92876379
42Spontaneous hematomas (HP:0007420)2.92278833
43Hypergammaglobulinemia (HP:0010702)2.90641977
44Abnormality of T cell number (HP:0011839)2.86826793
45Gastrointestinal stroma tumor (HP:0100723)2.80742920
46Autoimmune hemolytic anemia (HP:0001890)2.78802026
47Arterial thrombosis (HP:0004420)2.77811088
48T lymphocytopenia (HP:0005403)2.77007240
49Colitis (HP:0002583)2.75369139
50Chest pain (HP:0100749)2.70905755
51Gangrene (HP:0100758)2.68920970
52Inflammation of the large intestine (HP:0002037)2.68872901
53Autoimmune thrombocytopenia (HP:0001973)2.66004660
54Abnormality of the pleura (HP:0002103)2.61774891
55Gastrointestinal inflammation (HP:0004386)2.57529006
56Petechiae (HP:0000967)2.57494787
57Anorexia (HP:0002039)2.57322101
58Abnormality of T cells (HP:0002843)2.57078796
59Panhypogammaglobulinemia (HP:0003139)2.56622933
60Gingival bleeding (HP:0000225)2.54498727
61Osteomyelitis (HP:0002754)2.54077117
62Pulmonary embolism (HP:0002204)2.50224430
63Leukocytosis (HP:0001974)2.49836755
64Pustule (HP:0200039)2.43986739
65Lymphopenia (HP:0001888)2.40512006
66Abnormality of T cell physiology (HP:0011840)2.38950017
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.36531504
68Granulocytopenia (HP:0001913)2.32616779
69Purpura (HP:0000979)2.32515352
70Recurrent pneumonia (HP:0006532)2.31746038
71Nasal polyposis (HP:0100582)2.30077429
72Hypochromic anemia (HP:0001931)2.29471189
73Skin rash (HP:0000988)2.26746204
74Amyloidosis (HP:0011034)2.25644383
75Malnutrition (HP:0004395)2.23263590
76Skin ulcer (HP:0200042)2.23248474
77Epistaxis (HP:0000421)2.23006771
78Cheilitis (HP:0100825)2.22664870
79Sepsis (HP:0100806)2.21878994
80Chronic diarrhea (HP:0002028)2.21619022
81Increased cerebral lipofuscin (HP:0011813)2.21229060
82Dysostosis multiplex (HP:0000943)2.18539036
83Abnormality of the endocardium (HP:0004306)2.17529364
84IgM deficiency (HP:0002850)2.16844358
85Recurrent sinusitis (HP:0011108)2.16682199
86Abnormality of the pericardium (HP:0001697)2.15762298
87Abnormality of the nasal mucosa (HP:0000433)2.13793469
88Eosinophilia (HP:0001880)2.13137045
89IgG deficiency (HP:0004315)2.12848083
90Premature loss of primary teeth (HP:0006323)2.12576401
91Polyneuropathy (HP:0001271)2.11354604
92Abnormality of B cell number (HP:0010975)2.11127561
93Recurrent lower respiratory tract infections (HP:0002783)2.10469388
94Peritonitis (HP:0002586)2.10128733
95Emphysema (HP:0002097)2.09808979
96Glomerulopathy (HP:0100820)2.09805261
97Joint swelling (HP:0001386)2.09764942
98Episodic fever (HP:0001954)2.09686577
99Abnormality of the peritoneum (HP:0002585)2.09608916
100Vacuolated lymphocytes (HP:0001922)2.09168486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.29618664
2TYK24.06560160
3MAP4K13.92761070
4IKBKE3.14118820
5BLK2.99192184
6IRAK42.96802632
7ERN12.92786388
8JAK32.74856409
9MAP3K142.73735673
10TBK12.63757734
11JAK12.55219162
12FGFR42.47008191
13KIT2.38483939
14PRPF4B2.23274405
15CSK2.19200226
16MAP3K131.92315496
17TXK1.80907255
18SYK1.67959949
19IRAK31.67281954
20MAP2K31.63801860
21IKBKB1.62643426
22ZAP701.62238826
23FGFR31.58732908
24BTK1.57734219
25MATK1.57646224
26CSF1R1.55857367
27BMPR21.51146829
28FGR1.49980811
29FES1.44634279
30TNK21.42791139
31EPHB11.40912808
32LYN1.39274067
33MAP3K31.38606373
34GRK71.37375858
35JAK21.35735879
36HCK1.25174426
37GRK61.16541120
38TAOK11.16214565
39LCK1.16125261
40MAP3K111.15715524
41TESK21.12609652
42TAOK21.12522815
43SIK31.10898825
44TAOK31.01041006
45RIPK11.00028528
46ITK0.98258509
47CDC42BPA0.96640245
48IRAK10.95080984
49MAP3K10.92387619
50NME20.91711611
51MAPK110.84634639
52STK100.83735368
53MARK30.80059941
54TEC0.78222874
55EPHA30.74034206
56CHUK0.72055367
57PDK10.71008518
58TGFBR20.64331764
59SIK20.64033777
60PRKCQ0.62912143
61HIPK20.62802434
62MAPK70.60901079
63YES10.58524874
64TRIB30.58190262
65PDPK10.56989627
66IRAK20.56859306
67DDR20.52140273
68MOS0.50803104
69PIM20.49788861
70SMG10.49113981
71LRRK20.49019375
72PIM10.45907755
73MAP3K50.45680901
74PRKD20.45174695
75ADRBK20.44820366
76FYN0.44491543
77ARAF0.42307189
78ACVR1B0.41954051
79KSR20.41115984
80SIK10.39311159
81PRKCD0.38841288
82MAPKAPK20.36770778
83PTK60.35999604
84NLK0.35561284
85MAP2K60.34114585
86NEK90.34017200
87BMX0.33254707
88MAPK120.30569370
89ABL10.30277579
90PIK3CG0.25556964
91TLK10.25156714
92MARK20.22549916
93RPS6KA50.22341588
94MST1R0.22124001
95CDK40.20419132
96PTK2B0.19954848
97CAMKK20.19548164
98STK240.19104432
99MAP3K60.18616772
100MAPK40.18543238

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.70525340
2Autoimmune thyroid disease_Homo sapiens_hsa053203.42126057
3Graft-versus-host disease_Homo sapiens_hsa053323.35927473
4Asthma_Homo sapiens_hsa053103.02335975
5Staphylococcus aureus infection_Homo sapiens_hsa051503.01759821
6Leishmaniasis_Homo sapiens_hsa051403.00830862
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.89904619
8Type I diabetes mellitus_Homo sapiens_hsa049402.68530345
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60129983
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.52890484
11Osteoclast differentiation_Homo sapiens_hsa043802.45856164
12Primary immunodeficiency_Homo sapiens_hsa053402.41110271
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.37978828
14* Measles_Homo sapiens_hsa051622.25778957
15* Influenza A_Homo sapiens_hsa051642.25042709
16Antigen processing and presentation_Homo sapiens_hsa046122.23114166
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.12986122
18Tuberculosis_Homo sapiens_hsa051522.06450732
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99062605
20* Herpes simplex infection_Homo sapiens_hsa051681.97692704
21Viral myocarditis_Homo sapiens_hsa054161.96427914
22B cell receptor signaling pathway_Homo sapiens_hsa046621.88529877
23Rheumatoid arthritis_Homo sapiens_hsa053231.76658858
24Toxoplasmosis_Homo sapiens_hsa051451.70653614
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69273021
26Hematopoietic cell lineage_Homo sapiens_hsa046401.61304769
27Malaria_Homo sapiens_hsa051441.60894540
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60499474
29* Hepatitis C_Homo sapiens_hsa051601.56122992
30African trypanosomiasis_Homo sapiens_hsa051431.49065974
31TNF signaling pathway_Homo sapiens_hsa046681.47737376
32Legionellosis_Homo sapiens_hsa051341.39716979
33Other glycan degradation_Homo sapiens_hsa005111.39162998
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.33467674
35Pertussis_Homo sapiens_hsa051331.31952322
36Chemokine signaling pathway_Homo sapiens_hsa040621.31941840
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26664251
38Phagosome_Homo sapiens_hsa041451.25671255
39Hepatitis B_Homo sapiens_hsa051611.19440281
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16988667
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16453950
42T cell receptor signaling pathway_Homo sapiens_hsa046601.11965467
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10481293
44Acute myeloid leukemia_Homo sapiens_hsa052211.02270011
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98066933
46Lysosome_Homo sapiens_hsa041420.93103702
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91032143
48Apoptosis_Homo sapiens_hsa042100.90286585
49Salmonella infection_Homo sapiens_hsa051320.87473017
50Systemic lupus erythematosus_Homo sapiens_hsa053220.84780812
51Epstein-Barr virus infection_Homo sapiens_hsa051690.81626614
52Shigellosis_Homo sapiens_hsa051310.76995388
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.64668461
54Prolactin signaling pathway_Homo sapiens_hsa049170.63586687
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.61429988
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59921224
57Viral carcinogenesis_Homo sapiens_hsa052030.55456726
58Pancreatic cancer_Homo sapiens_hsa052120.50925341
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.50674514
60Platelet activation_Homo sapiens_hsa046110.48838184
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48304474
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46764812
63HTLV-I infection_Homo sapiens_hsa051660.46491797
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46384837
65Complement and coagulation cascades_Homo sapiens_hsa046100.41584369
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36779069
67VEGF signaling pathway_Homo sapiens_hsa043700.36774126
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36048766
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34096989
70Amoebiasis_Homo sapiens_hsa051460.32512690
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.31661879
72Endocytosis_Homo sapiens_hsa041440.31653408
73Non-small cell lung cancer_Homo sapiens_hsa052230.30860894
74Chronic myeloid leukemia_Homo sapiens_hsa052200.28351279
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.27939168
76Insulin resistance_Homo sapiens_hsa049310.27255910
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26924410
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24401675
79HIF-1 signaling pathway_Homo sapiens_hsa040660.22859850
80Bladder cancer_Homo sapiens_hsa052190.21874089
81Notch signaling pathway_Homo sapiens_hsa043300.21532033
82Fructose and mannose metabolism_Homo sapiens_hsa000510.18044141
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.17728909
84Galactose metabolism_Homo sapiens_hsa000520.17582270
85Type II diabetes mellitus_Homo sapiens_hsa049300.17202240
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16209505
87Arachidonic acid metabolism_Homo sapiens_hsa005900.15729866
88FoxO signaling pathway_Homo sapiens_hsa040680.15537833
89Sulfur metabolism_Homo sapiens_hsa009200.14712038
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14514768
91Dorso-ventral axis formation_Homo sapiens_hsa043200.12747209
92Renal cell carcinoma_Homo sapiens_hsa052110.11136026
93Prion diseases_Homo sapiens_hsa050200.10879235
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10783903
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.09444827
96PPAR signaling pathway_Homo sapiens_hsa033200.09429851
97Collecting duct acid secretion_Homo sapiens_hsa049660.09039188
98Sphingolipid metabolism_Homo sapiens_hsa006000.08479744
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05690790
100GnRH signaling pathway_Homo sapiens_hsa049120.05179283

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