OAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.69115411
2modulation by symbiont of host immune response (GO:0052553)6.69115411
3positive regulation by symbiont of host defense response (GO:0052509)6.69115411
4modulation by symbiont of host defense response (GO:0052031)6.69115411
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.69115411
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.69115411
7positive regulation of interferon-alpha production (GO:0032727)5.49608782
8response to interferon-alpha (GO:0035455)5.39966543
9* type I interferon signaling pathway (GO:0060337)5.39891284
10* cellular response to type I interferon (GO:0071357)5.39891284
11* response to type I interferon (GO:0034340)5.39113902
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.36204992
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.36204992
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.26811434
15regulation of interferon-alpha production (GO:0032647)5.21476798
16positive regulation of gamma-delta T cell activation (GO:0046645)5.17733326
17response to host immune response (GO:0052572)4.98880602
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.98880602
19regulation of interferon-beta biosynthetic process (GO:0045357)4.90888894
20antigen processing and presentation of endogenous antigen (GO:0019883)4.86978104
21macrophage activation involved in immune response (GO:0002281)4.81915972
22response to peptidoglycan (GO:0032494)4.77498928
23immunoglobulin mediated immune response (GO:0016064)4.67963303
24response to host (GO:0075136)4.52187883
25response to host defenses (GO:0052200)4.52187883
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.52187883
27neutrophil activation involved in immune response (GO:0002283)4.43721010
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.09026719
29positive regulation of interferon-beta production (GO:0032728)4.07939665
30negative regulation of viral genome replication (GO:0045071)4.03892615
31positive regulation of antigen processing and presentation (GO:0002579)4.01552790
32negative regulation of T cell mediated immunity (GO:0002710)3.98850446
33detection of bacterium (GO:0016045)3.93783008
34regulation of MHC class I biosynthetic process (GO:0045343)3.87614434
35positive regulation of type 2 immune response (GO:0002830)3.85729343
36response to muramyl dipeptide (GO:0032495)3.85519891
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.78994764
38regulation of B cell receptor signaling pathway (GO:0050855)3.71985097
39regulation of RIG-I signaling pathway (GO:0039535)3.70875698
40* interferon-gamma-mediated signaling pathway (GO:0060333)3.70491226
41response to interferon-beta (GO:0035456)3.70164515
42positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.69456437
43microglial cell activation (GO:0001774)3.64581168
44cellular response to virus (GO:0098586)3.63252125
45regulation of viral genome replication (GO:0045069)3.63147629
46regulation of type I interferon-mediated signaling pathway (GO:0060338)3.61199230
47myeloid cell activation involved in immune response (GO:0002275)3.61183404
48regulation of T-helper 1 cell differentiation (GO:0045625)3.59430655
49detection of molecule of bacterial origin (GO:0032490)3.58578353
50regulation of gamma-delta T cell activation (GO:0046643)3.58073262
51natural killer cell mediated immunity (GO:0002228)3.57683062
52natural killer cell mediated cytotoxicity (GO:0042267)3.57683062
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57517137
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.53498811
55defense response to protozoan (GO:0042832)3.52273131
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.50439554
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.49078383
58regulation of type 2 immune response (GO:0002828)3.47015764
59regulation of T cell tolerance induction (GO:0002664)3.44307190
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.43178452
61germinal center formation (GO:0002467)3.41982073
62positive regulation of cellular amide metabolic process (GO:0034250)3.41597563
63cellular response to interferon-beta (GO:0035458)3.41576830
64negative regulation of viral process (GO:0048525)3.40560814
65B cell mediated immunity (GO:0019724)3.39165805
66negative regulation of cytokine production involved in immune response (GO:0002719)3.38011158
67I-kappaB phosphorylation (GO:0007252)3.37658820
68regulation of antigen processing and presentation (GO:0002577)3.37613120
69negative thymic T cell selection (GO:0045060)3.30506438
70respiratory burst (GO:0045730)3.27575426
71response to interleukin-15 (GO:0070672)3.27560134
72negative regulation of interleukin-12 production (GO:0032695)3.26366532
73negative regulation of type 2 immune response (GO:0002829)3.26265161
74positive regulation of B cell differentiation (GO:0045579)3.21848637
75myeloid dendritic cell differentiation (GO:0043011)3.21638955
76positive regulation of toll-like receptor signaling pathway (GO:0034123)3.21401538
77* defense response to virus (GO:0051607)3.20482452
78macrophage activation (GO:0042116)3.20243141
79response to protozoan (GO:0001562)3.19866107
80granulocyte activation (GO:0036230)3.18302208
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17865305
82* response to interferon-gamma (GO:0034341)3.17763530
83negative T cell selection (GO:0043383)3.17507250
84cellular response to interleukin-15 (GO:0071350)3.14825109
85neutrophil activation (GO:0042119)3.14293615
86lymphocyte chemotaxis (GO:0048247)3.11965153
87leukocyte aggregation (GO:0070486)3.11656343
88negative regulation of leukocyte mediated immunity (GO:0002704)3.10675925
89T cell migration (GO:0072678)3.10578705
90natural killer cell activation involved in immune response (GO:0002323)3.10439545
91regulation of tolerance induction (GO:0002643)3.10413381
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09747497
93negative regulation of cell killing (GO:0031342)3.09625461
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09625461
95negative regulation of innate immune response (GO:0045824)3.07192525
96NIK/NF-kappaB signaling (GO:0038061)3.07058460
97cellular response to exogenous dsRNA (GO:0071360)3.05867598
98cellular response to interferon-alpha (GO:0035457)3.04040230
99myeloid dendritic cell activation (GO:0001773)3.02415761
100regulation of gamma-delta T cell differentiation (GO:0045586)3.01392879
101T-helper 1 type immune response (GO:0042088)3.01172234
102regulation of interferon-beta production (GO:0032648)3.00700964
103regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.00281274
104detection of other organism (GO:0098543)2.99938506
105positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.97948358
106JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.93062047
107interferon-gamma secretion (GO:0072643)2.91686852
108regulation of interleukin-8 biosynthetic process (GO:0045414)2.91610315
109mature B cell differentiation (GO:0002335)2.91449060
110positive regulation of defense response to virus by host (GO:0002230)2.91344506
111regulation of interleukin-12 production (GO:0032655)2.90029405
112regulation of alpha-beta T cell proliferation (GO:0046640)2.89278403
113tolerance induction (GO:0002507)2.88689808
114pinocytosis (GO:0006907)2.88601392
115regulation of T cell mediated cytotoxicity (GO:0001914)2.88474844
116positive regulation of chemokine biosynthetic process (GO:0045080)2.88129782
117positive regulation of response to biotic stimulus (GO:0002833)2.88076368
118* cellular response to interferon-gamma (GO:0071346)2.87490553
119antigen processing and presentation via MHC class Ib (GO:0002475)2.87215220
120positive regulation of humoral immune response (GO:0002922)2.85576398
121detection of external biotic stimulus (GO:0098581)2.85239801
122positive regulation of natural killer cell differentiation (GO:0032825)2.80796446
123B cell receptor signaling pathway (GO:0050853)2.78631223
124positive regulation of interleukin-1 beta secretion (GO:0050718)2.78413422
125neutrophil mediated immunity (GO:0002446)2.78171983
126negative regulation of myeloid cell apoptotic process (GO:0033033)2.78125990
127positive regulation of interleukin-17 production (GO:0032740)2.76095190
128regulation of interleukin-17 production (GO:0032660)2.75141589
129regulation of mast cell degranulation (GO:0043304)2.74969707
130regulation of B cell differentiation (GO:0045577)2.74425870
131regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.72806060
132positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72268328
133detection of biotic stimulus (GO:0009595)2.72176253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.42219500
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.33268375
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.26777685
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.54791170
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.26689995
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.16158953
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.85475973
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71830458
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.54428026
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42519851
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10885217
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.94891797
13GATA1_22025678_ChIP-Seq_K562_Human2.86431883
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.79076739
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64062857
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62147645
17SCL_19346495_ChIP-Seq_HPC-7_Human2.57234982
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.54456516
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54129220
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47203310
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18759401
22SPI1_23547873_ChIP-Seq_NB4_Human2.17321418
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10596311
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00417302
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99197401
26SPI1_23127762_ChIP-Seq_K562_Human1.95211353
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93220711
28MAF_26560356_Chip-Seq_TH1_Human1.86482694
29MYB_26560356_Chip-Seq_TH2_Human1.86022553
30VDR_21846776_ChIP-Seq_THP-1_Human1.82874554
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78213487
32VDR_24763502_ChIP-Seq_THP-1_Human1.77359497
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77338518
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.76252818
35MYB_26560356_Chip-Seq_TH1_Human1.71377446
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70827526
37PU_27001747_Chip-Seq_BMDM_Mouse1.70532379
38RUNX_20019798_ChIP-Seq_JUKART_Human1.67377333
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64742404
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.56191935
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54666010
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51320467
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47377376
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45518147
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40144543
46* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37939078
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37693359
48UTX_26944678_Chip-Seq_JUKART_Human1.35595601
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35400919
50TCF7_22412390_ChIP-Seq_EML_Mouse1.31578514
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31364125
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29446363
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28363385
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27471361
55VDR_24787735_ChIP-Seq_THP-1_Human1.23921868
56* GATA3_27048872_Chip-Seq_THYMUS_Human1.16159690
57MYC_22102868_ChIP-Seq_BL_Human1.13985710
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13671670
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12022381
60* GATA3_26560356_Chip-Seq_TH2_Human1.11987798
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11078456
62* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10368985
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.09802386
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.08686683
65E2F7_22180533_ChIP-Seq_HELA_Human1.08020519
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.07930728
67MAF_26560356_Chip-Seq_TH2_Human1.05356064
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05324183
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04614783
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03996516
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03877162
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03504554
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02144035
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01586419
75* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99961406
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96791488
77ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95316041
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95054983
79LXR_22292898_ChIP-Seq_THP-1_Human0.93364513
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93046198
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92814156
82* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91329028
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88470018
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86758286
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.85189608
86GATA2_19941826_ChIP-Seq_K562_Human0.84204555
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83372686
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83101136
89TFEB_21752829_ChIP-Seq_HELA_Human0.81204832
90GATA1_19941826_ChIP-Seq_K562_Human0.81143928
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81036444
92KDM2B_26808549_Chip-Seq_DND41_Human0.80782042
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80623490
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80384603
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78647243
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.78012978
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76920318
98BCL6_27268052_Chip-Seq_Bcells_Human0.76803214
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76151075
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72915382
101BCOR_27268052_Chip-Seq_Bcells_Human0.72474279
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72165860
103SPI1_20517297_ChIP-Seq_HL60_Human0.69221537
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68925936
105SMRT_27268052_Chip-Seq_Bcells_Human0.68039898
106NCOR1_26117541_ChIP-Seq_K562_Human0.65756071
107* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64694211
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.64592328
109P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64339308
110CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64150659
111EGR1_19032775_ChIP-ChIP_M12_Human0.63638375
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.63133320
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.63133320
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.63004246
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.61068553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.26523247
2MP0009785_altered_susceptibility_to3.64869832
3MP0003436_decreased_susceptibility_to3.36321595
4MP0001790_abnormal_immune_system3.02429401
5MP0005387_immune_system_phenotype3.02429401
6MP0005025_abnormal_response_to3.00341008
7MP0000569_abnormal_digit_pigmentation2.99339234
8MP0000685_abnormal_immune_system2.98538016
9MP0002419_abnormal_innate_immunity2.90947280
10MP0005058_abnormal_lysosome_morphology2.90095932
11MP0005000_abnormal_immune_tolerance2.89285531
12MP0003303_peritoneal_inflammation2.82915470
13MP0003724_increased_susceptibility_to2.80960717
14MP0001800_abnormal_humoral_immune2.72757602
15MP0002148_abnormal_hypersensitivity_rea2.67490607
16MP0002452_abnormal_antigen_presenting2.59612244
17MP0002723_abnormal_immune_serum2.52866335
18MP0006082_CNS_inflammation2.50038133
19MP0004510_myositis2.41573953
20MP0005671_abnormal_response_to2.36248894
21MP0005464_abnormal_platelet_physiology2.26432015
22MP0001819_abnormal_immune_cell2.22691915
23MP0002420_abnormal_adaptive_immunity2.20657711
24MP0004947_skin_inflammation2.18709699
25MP0003172_abnormal_lysosome_physiology2.16701034
26MP0009278_abnormal_bone_marrow2.15275574
27MP0001533_abnormal_skeleton_physiology1.92674194
28MP0002166_altered_tumor_susceptibility1.83662542
29MP0002396_abnormal_hematopoietic_system1.79967766
30MP0010155_abnormal_intestine_physiology1.78229525
31MP0001845_abnormal_inflammatory_respons1.78228110
32MP0002405_respiratory_system_inflammati1.76797849
33MP0002398_abnormal_bone_marrow1.74676352
34MP0005451_abnormal_body_composition1.74662731
35MP0005397_hematopoietic_system_phenotyp1.73590018
36MP0001545_abnormal_hematopoietic_system1.73590018
37MP0009840_abnormal_foam_cell1.73164485
38MP0000716_abnormal_immune_system1.72688199
39MP0008469_abnormal_protein_level1.69427665
40MP0003300_gastrointestinal_ulcer1.68984985
41MP0001853_heart_inflammation1.68115948
42MP0005174_abnormal_tail_pigmentation1.64353581
43MP0002006_tumorigenesis1.58284766
44MP0000343_altered_response_to1.56866644
45MP0000689_abnormal_spleen_morphology1.54736303
46MP0003191_abnormal_cellular_cholesterol1.54142900
47MP0003448_altered_tumor_morphology1.48822252
48MP0009764_decreased_sensitivity_to1.46928272
49MP0002429_abnormal_blood_cell1.43523858
50MP0003763_abnormal_thymus_physiology1.41759062
51MP0004808_abnormal_hematopoietic_stem1.39210285
52MP0002722_abnormal_immune_system1.36915900
53MP0009333_abnormal_splenocyte_physiolog1.30802930
54MP0003075_altered_response_to1.30230575
55MP0002138_abnormal_hepatobiliary_system1.24856955
56MP0003183_abnormal_peptide_metabolism1.24366448
57MP0010307_abnormal_tumor_latency1.22981203
58MP0001873_stomach_inflammation1.22406154
59MP0000604_amyloidosis1.19684376
60MP0009763_increased_sensitivity_to1.17279349
61MP0002998_abnormal_bone_remodeling1.14603105
62MP0000858_altered_metastatic_potential1.12780937
63MP0008260_abnormal_autophagy1.10931009
64MP0000465_gastrointestinal_hemorrhage1.03340321
65MP0003566_abnormal_cell_adhesion1.02147542
66MP0000015_abnormal_ear_pigmentation1.01898288
67MP0001851_eye_inflammation1.01808271
68MP0005310_abnormal_salivary_gland1.00419231
69MP0002933_joint_inflammation1.00042677
70MP0002254_reproductive_system_inflammat0.96177852
71MP0005167_abnormal_blood-brain_barrier0.94808219
72MP0002332_abnormal_exercise_endurance0.93038609
73MP0003828_pulmonary_edema0.92671390
74MP0000371_diluted_coat_color0.92624161
75MP0001958_emphysema0.92557555
76MP0003806_abnormal_nucleotide_metabolis0.92498743
77MP0008004_abnormal_stomach_pH0.91270914
78MP0005023_abnormal_wound_healing0.88912523
79MP0004883_abnormal_blood_vessel0.88786858
80MP0005166_decreased_susceptibility_to0.88273906
81MP0005390_skeleton_phenotype0.88226381
82MP0000703_abnormal_thymus_morphology0.86230516
83MP0002277_abnormal_respiratory_mucosa0.81761160
84MP0000249_abnormal_blood_vessel0.81015158
85MP0001348_abnormal_lacrimal_gland0.80999141
86MP0003656_abnormal_erythrocyte_physiolo0.80798319
87MP0000490_abnormal_crypts_of0.80219090
88MP0005076_abnormal_cell_differentiation0.79166434
89MP0001663_abnormal_digestive_system0.74608595
90MP0004381_abnormal_hair_follicle0.74488239
91MP0005164_abnormal_response_to0.74423918
92MP0002132_abnormal_respiratory_system0.74236786
93MP0003453_abnormal_keratinocyte_physiol0.74076686
94MP0004782_abnormal_surfactant_physiolog0.73026474
95MP0003221_abnormal_cardiomyocyte_apopto0.70949969
96MP0003690_abnormal_glial_cell0.70176224
97MP0003866_abnormal_defecation0.69416351
98MP0002139_abnormal_hepatobiliary_system0.69328191
99MP0008874_decreased_physiological_sensi0.67961966
100MP0003091_abnormal_cell_migration0.66145922
101MP0008438_abnormal_cutaneous_collagen0.64942657
102MP0003045_fibrosis0.63265874
103MP0009765_abnormal_xenobiotic_induced0.62386823
104MP0000609_abnormal_liver_physiology0.61998569
105MP0010352_gastrointestinal_tract_polyps0.60507068
106MP0002136_abnormal_kidney_physiology0.59586651
107MP0005075_abnormal_melanosome_morpholog0.59296545
108MP0005083_abnormal_biliary_tract0.59111457
109MP0003795_abnormal_bone_structure0.58924095
110MP0002095_abnormal_skin_pigmentation0.58395812
111MP0006054_spinal_hemorrhage0.56316324
112MP0002019_abnormal_tumor_incidence0.55693767
113MP0000767_abnormal_smooth_muscle0.55304813
114MP0002693_abnormal_pancreas_physiology0.55018329
115MP0001881_abnormal_mammary_gland0.52048981
116MP0000920_abnormal_myelination0.51151176
117MP0002163_abnormal_gland_morphology0.49307941
118MP0002877_abnormal_melanocyte_morpholog0.49086658

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.46616718
2Recurrent bacterial skin infections (HP:0005406)5.89182017
3Eczematoid dermatitis (HP:0000976)5.68137911
4Elevated erythrocyte sedimentation rate (HP:0003565)4.94678853
5Myositis (HP:0100614)4.65052788
6Abnormality of macrophages (HP:0004311)4.53434311
7Vacuolated lymphocytes (HP:0001922)4.36688017
8Recurrent gram-negative bacterial infections (HP:0005420)4.25400179
9Chronic otitis media (HP:0000389)4.23193596
10Autoimmune thrombocytopenia (HP:0001973)4.14584587
11Orchitis (HP:0100796)4.12278192
12Systemic lupus erythematosus (HP:0002725)4.03925999
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.93854933
14Mediastinal lymphadenopathy (HP:0100721)3.93219006
15Increased cerebral lipofuscin (HP:0011813)3.92971655
16Recurrent skin infections (HP:0001581)3.80411455
17Optic neuritis (HP:0100653)3.76201118
18Retrobulbar optic neuritis (HP:0100654)3.76201118
19Recurrent fungal infections (HP:0002841)3.67197105
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.64622746
21Recurrent viral infections (HP:0004429)3.61776209
22Prostate neoplasm (HP:0100787)3.60736872
23Encephalitis (HP:0002383)3.53788497
24T lymphocytopenia (HP:0005403)3.53771515
25Abnormality of T cell number (HP:0011839)3.50925673
26Gingivitis (HP:0000230)3.50308021
27Periodontitis (HP:0000704)3.50099031
28Stomatitis (HP:0010280)3.50092196
29Vasculitis (HP:0002633)3.49067730
30Pustule (HP:0200039)3.14593360
31Loss of speech (HP:0002371)3.13013345
32Nasal polyposis (HP:0100582)3.02926359
33Basal ganglia calcification (HP:0002135)2.96621356
34Agammaglobulinemia (HP:0004432)2.96421340
35Abnormality of T cells (HP:0002843)2.93303504
36Panhypogammaglobulinemia (HP:0003139)2.89161086
37Recurrent cutaneous fungal infections (HP:0011370)2.88329602
38Chronic mucocutaneous candidiasis (HP:0002728)2.88329602
39Abnormality of the nasal mucosa (HP:0000433)2.87122400
40Gingival bleeding (HP:0000225)2.84929384
41Recurrent bronchitis (HP:0002837)2.82025240
42Interstitial pulmonary disease (HP:0006530)2.81313432
43Cellulitis (HP:0100658)2.78227671
44Lymphopenia (HP:0001888)2.77288330
45Glomerulonephritis (HP:0000099)2.76617539
46Gangrene (HP:0100758)2.75825950
47Thick nail (HP:0001805)2.74245909
48Colitis (HP:0002583)2.73529495
49Chronic obstructive pulmonary disease (HP:0006510)2.73028986
50Obstructive lung disease (HP:0006536)2.73028986
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.70633606
52Premature loss of primary teeth (HP:0006323)2.67217954
53Arterial thrombosis (HP:0004420)2.63600714
54Disinhibition (HP:0000734)2.63203700
55Axonal loss (HP:0003447)2.61017347
56Pulmonary infiltrates (HP:0002113)2.59294984
57Osteomyelitis (HP:0002754)2.57186328
58Abnormality of the pleura (HP:0002103)2.56219791
59Anorexia (HP:0002039)2.55317609
60Abnormality of T cell physiology (HP:0011840)2.55003534
61Dysostosis multiplex (HP:0000943)2.53661255
62Inflammation of the large intestine (HP:0002037)2.51566011
63Pulmonary embolism (HP:0002204)2.51177269
64Hematochezia (HP:0002573)2.50780002
65Increased IgE level (HP:0003212)2.50267780
66IgG deficiency (HP:0004315)2.49124185
67Abnormality of the prostate (HP:0008775)2.45682396
68IgA deficiency (HP:0002720)2.45105452
69Prolonged bleeding time (HP:0003010)2.44738405
70Meningitis (HP:0001287)2.43809217
71Granulocytopenia (HP:0001913)2.42907915
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.42361197
73Osteolytic defects of the hand bones (HP:0009699)2.42361197
74Leukocytosis (HP:0001974)2.41414218
75Recurrent sinusitis (HP:0011108)2.41336925
76Gastrointestinal inflammation (HP:0004386)2.40779303
77Epistaxis (HP:0000421)2.37653683
78Hypergammaglobulinemia (HP:0010702)2.36347273
79Keratoconjunctivitis sicca (HP:0001097)2.36296983
80Urticaria (HP:0001025)2.36044964
81Hemoptysis (HP:0002105)2.35971304
82Abnormality of the endocardium (HP:0004306)2.34769120
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33527146
84Abnormality of B cell number (HP:0010975)2.32586632
85Spontaneous hematomas (HP:0007420)2.29028754
86Joint swelling (HP:0001386)2.26136953
87Nephritis (HP:0000123)2.24843005
88Petechiae (HP:0000967)2.24433664
89IgM deficiency (HP:0002850)2.20895276
90Sepsis (HP:0100806)2.18136772
91Abnormality of polysaccharide metabolism (HP:0011012)2.17420339
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17420339
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17420339
94Emphysema (HP:0002097)2.14766220
95Abnormality of the pericardium (HP:0001697)2.14030231
96Purpura (HP:0000979)2.13697145
97Abnormality of liposaccharide metabolism (HP:0010968)2.13457962
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.13457962
99Abnormality of glycolipid metabolism (HP:0010969)2.13457962
100Gastrointestinal stroma tumor (HP:0100723)2.13435362
101Keratoconjunctivitis (HP:0001096)2.13376620
102Skin rash (HP:0000988)2.13014161
103Chronic diarrhea (HP:0002028)2.12900544
104Cheilitis (HP:0100825)2.12657465
105Pathologic fracture (HP:0002756)2.12604056
106Mucopolysacchariduria (HP:0008155)2.12347749
107Urinary glycosaminoglycan excretion (HP:0003541)2.12347749
108Glomerulopathy (HP:0100820)2.12269230
109Amaurosis fugax (HP:0100576)2.12256732
110Arthralgia (HP:0002829)2.12020433
111Hypochromic anemia (HP:0001931)2.10811675
112Polyneuropathy (HP:0001271)2.10782462
113B lymphocytopenia (HP:0010976)2.10265280
114Tetraparesis (HP:0002273)2.09669332
115Absent frontal sinuses (HP:0002688)2.05402538
116Chronic sinusitis (HP:0011109)2.05349923
117Eosinophilia (HP:0001880)2.01819300
118Skin ulcer (HP:0200042)2.01677535
119Keratitis (HP:0000491)2.01532384
120Recurrent pneumonia (HP:0006532)2.01419734
121Porencephaly (HP:0002132)2.01395030
122Abnormality of the fingertips (HP:0001211)1.99504485
123Gastrointestinal infarctions (HP:0005244)1.99186132
124Bone pain (HP:0002653)1.98948484
125Restrictive lung disease (HP:0002091)1.95374781
126Neoplasm of head and neck (HP:0012288)1.94891958
127Esophageal neoplasm (HP:0100751)1.94891958
128Increased IgM level (HP:0003496)1.94781782
129Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93843582
130Myocardial infarction (HP:0001658)1.93579943
131Chest pain (HP:0100749)1.91740974
132Autoimmune hemolytic anemia (HP:0001890)1.91222043
133Thrombocytosis (HP:0001894)1.87184953
134Vertebral compression fractures (HP:0002953)1.85983775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.35617087
2KIT3.83040073
3IKBKE3.61248034
4TBK13.46667762
5MAP3K143.35461697
6MAP4K13.28218147
7IRAK42.90868791
8PRPF4B2.88673264
9RIPK42.79804245
10JAK12.64351639
11BLK2.60328637
12IRAK32.55046320
13ERN12.52318970
14JAK32.51556642
15TXK2.36370196
16TAOK32.02068296
17IKBKB1.95255155
18MAP3K131.89594062
19FGFR41.88111440
20ZAP701.72580161
21CSF1R1.64975018
22TEC1.61510087
23CSK1.60914975
24HCK1.59675415
25BTK1.54553438
26SYK1.52490542
27EPHB11.52021237
28GRK71.51725369
29FLT31.49823550
30TTN1.43563692
31FES1.40286823
32TGFBR21.39437272
33TNK21.38812842
34LCK1.28640415
35CHUK1.22396863
36TAOK21.19156994
37CAMK1D1.18910882
38PIM21.15421412
39MATK1.11783550
40FGFR31.11215738
41LYN1.10044585
42NEK90.99960292
43CDC42BPA0.97767521
44PIM10.96554046
45SMG10.96141391
46TAOK10.95648447
47MAP2K30.95476662
48FGR0.94299838
49JAK20.93094815
50NME20.92900591
51STK100.92235482
52RIPK10.88411858
53MAP3K110.87823229
54CDK120.87753359
55RPS6KA40.86845944
56PTK60.85961187
57MAP3K100.85733800
58SIK20.85692695
59ITK0.82837492
60MAP3K10.80793179
61STK240.78097521
62CAMK1G0.74063740
63PKN20.73927900
64EIF2AK20.73637729
65EPHA30.73469070
66MAPK70.71248921
67TESK20.67802963
68MARK30.65574353
69CLK10.63213639
70DDR20.60947780
71EGFR0.59957620
72TRPM70.58263465
73GRK60.57529875
74MAPK110.56667487
75IRAK20.56600851
76NLK0.56156298
77STK40.55466432
78DAPK20.54975374
79MAP3K50.54673781
80TGFBR10.53536266
81ABL10.52226697
82MOS0.51186689
83TIE10.50275395
84LRRK20.49886435
85MAP3K30.49692840
86CDK60.49240087
87ACVR1B0.47205780
88PRKCD0.43688992
89IRAK10.43637076
90RPS6KA60.43519789
91PRKD20.42486411
92PDPK10.42476662
93STK30.41120055
94YES10.39818992
95MST1R0.39077860
96KSR20.38649824
97CDK40.38070849
98FYN0.36206189
99MARK20.32261947
100DAPK30.31751639
101PIK3CG0.31542229
102HIPK20.31346966
103MAPK120.31101429
104CDK190.29710081
105ADRBK20.29640059
106MAPKAPK20.29455216
107PRKCH0.27551871
108KDR0.27020815
109PDK10.26991469
110MELK0.26267703
111ATR0.25746860
112PRKG20.25465683
113IGF1R0.25118647
114MAP2K60.24904243
115PRKCQ0.24685509
116MAPK30.24421002
117DYRK1B0.24014412
118RPS6KL10.23905551
119RPS6KC10.23905551
120CAMKK20.23887181
121TRIB30.23800980
122BMPR20.23642088
123MAPK40.23281192
124SIK10.23177605
125SIK30.20746165
126BMX0.19576289

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.25966238
2Staphylococcus aureus infection_Homo sapiens_hsa051503.18118235
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.91842616
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.87372944
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.82207400
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.69344568
7* Measles_Homo sapiens_hsa051622.57485104
8Osteoclast differentiation_Homo sapiens_hsa043802.49019893
9* Influenza A_Homo sapiens_hsa051642.30860120
10Pertussis_Homo sapiens_hsa051332.28427643
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22005663
12Legionellosis_Homo sapiens_hsa051342.18674839
13Caffeine metabolism_Homo sapiens_hsa002322.17724453
14Malaria_Homo sapiens_hsa051442.14095476
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10376480
16B cell receptor signaling pathway_Homo sapiens_hsa046622.03108766
17Tuberculosis_Homo sapiens_hsa051522.01597448
18* Herpes simplex infection_Homo sapiens_hsa051681.97732804
19Allograft rejection_Homo sapiens_hsa053301.80493757
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.79392504
21TNF signaling pathway_Homo sapiens_hsa046681.78467565
22Toxoplasmosis_Homo sapiens_hsa051451.76764767
23Hematopoietic cell lineage_Homo sapiens_hsa046401.75775592
24Primary immunodeficiency_Homo sapiens_hsa053401.72253223
25Other glycan degradation_Homo sapiens_hsa005111.70245073
26Graft-versus-host disease_Homo sapiens_hsa053321.65774533
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.61432475
28Lysosome_Homo sapiens_hsa041421.59189290
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57059340
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.54168946
31Asthma_Homo sapiens_hsa053101.54153009
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52862066
33* Hepatitis C_Homo sapiens_hsa051601.48185447
34Antigen processing and presentation_Homo sapiens_hsa046121.45531670
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39099233
36Rheumatoid arthritis_Homo sapiens_hsa053231.37459684
37African trypanosomiasis_Homo sapiens_hsa051431.36571994
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35409123
39Hepatitis B_Homo sapiens_hsa051611.33634207
40Apoptosis_Homo sapiens_hsa042101.32468647
41Salmonella infection_Homo sapiens_hsa051321.27132742
42Chemokine signaling pathway_Homo sapiens_hsa040621.23968275
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21805114
44Shigellosis_Homo sapiens_hsa051311.20647288
45Phagosome_Homo sapiens_hsa041451.10487748
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09081650
47Acute myeloid leukemia_Homo sapiens_hsa052211.08569901
48T cell receptor signaling pathway_Homo sapiens_hsa046600.96224012
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93931704
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.92444436
51Viral myocarditis_Homo sapiens_hsa054160.88890412
52Chronic myeloid leukemia_Homo sapiens_hsa052200.84195586
53Complement and coagulation cascades_Homo sapiens_hsa046100.84172705
54Amoebiasis_Homo sapiens_hsa051460.83447776
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82132681
56Type I diabetes mellitus_Homo sapiens_hsa049400.79305681
57Platelet activation_Homo sapiens_hsa046110.79170676
58Small cell lung cancer_Homo sapiens_hsa052220.76228737
59Systemic lupus erythematosus_Homo sapiens_hsa053220.70882439
60Pancreatic cancer_Homo sapiens_hsa052120.70583550
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.68503613
62Prolactin signaling pathway_Homo sapiens_hsa049170.67082121
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67081435
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64647369
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63925025
66Epstein-Barr virus infection_Homo sapiens_hsa051690.61220583
67ABC transporters_Homo sapiens_hsa020100.59895585
68Notch signaling pathway_Homo sapiens_hsa043300.58090298
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55713991
70HIF-1 signaling pathway_Homo sapiens_hsa040660.55664985
71Autoimmune thyroid disease_Homo sapiens_hsa053200.54826863
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53201900
73Insulin resistance_Homo sapiens_hsa049310.52395542
74Type II diabetes mellitus_Homo sapiens_hsa049300.50995001
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48761245
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.48386580
77Viral carcinogenesis_Homo sapiens_hsa052030.45133579
78Renal cell carcinoma_Homo sapiens_hsa052110.39436161
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.38716564
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38314403
81Dorso-ventral axis formation_Homo sapiens_hsa043200.32794854
82HTLV-I infection_Homo sapiens_hsa051660.30102641
83Bladder cancer_Homo sapiens_hsa052190.29372604
84Proteoglycans in cancer_Homo sapiens_hsa052050.29147404
85Lysine degradation_Homo sapiens_hsa003100.29093803
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28063373
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27622210
88VEGF signaling pathway_Homo sapiens_hsa043700.27186699
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24358394
90MicroRNAs in cancer_Homo sapiens_hsa052060.23810264
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.23568186
92Prion diseases_Homo sapiens_hsa050200.23088970
93Sphingolipid metabolism_Homo sapiens_hsa006000.22681738
94Endocytosis_Homo sapiens_hsa041440.22442682
95MAPK signaling pathway_Homo sapiens_hsa040100.22062726
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21303705
97Prostate cancer_Homo sapiens_hsa052150.21030922
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18759322
99Mineral absorption_Homo sapiens_hsa049780.16526698
100mTOR signaling pathway_Homo sapiens_hsa041500.16224173
101GnRH signaling pathway_Homo sapiens_hsa049120.16099624
102Endometrial cancer_Homo sapiens_hsa052130.15447793
103Non-small cell lung cancer_Homo sapiens_hsa052230.15231178
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14964182
105Galactose metabolism_Homo sapiens_hsa000520.14931314
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13239158
107FoxO signaling pathway_Homo sapiens_hsa040680.13081828
108Inositol phosphate metabolism_Homo sapiens_hsa005620.12700990
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12045384
110Focal adhesion_Homo sapiens_hsa045100.11316680
111p53 signaling pathway_Homo sapiens_hsa041150.11151981
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10656992
113Choline metabolism in cancer_Homo sapiens_hsa052310.10509511

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