OAS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.48763469
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.48763469
3antigen processing and presentation of endogenous antigen (GO:0019883)5.96013881
4positive regulation of interferon-alpha production (GO:0032727)5.94051310
5positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.73822315
6* response to type I interferon (GO:0034340)5.65385145
7* cellular response to type I interferon (GO:0071357)5.62657931
8* type I interferon signaling pathway (GO:0060337)5.62657931
9regulation of interferon-alpha production (GO:0032647)5.62619879
10positive regulation by symbiont of host defense response (GO:0052509)5.42095569
11modulation by symbiont of host defense response (GO:0052031)5.42095569
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.42095569
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.42095569
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.42095569
15modulation by symbiont of host immune response (GO:0052553)5.42095569
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.28562714
17regulation of interferon-beta biosynthetic process (GO:0045357)5.08753399
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.80374819
19negative regulation of cell killing (GO:0031342)4.80374819
20immunoglobulin mediated immune response (GO:0016064)4.57494787
21cellular response to virus (GO:0098586)4.54617458
22response to interferon-alpha (GO:0035455)4.50825742
23positive regulation of gamma-delta T cell activation (GO:0046645)4.47660921
24response to peptidoglycan (GO:0032494)4.34203813
25neutrophil activation involved in immune response (GO:0002283)4.33611826
26regulation of MHC class I biosynthetic process (GO:0045343)4.27763876
27positive regulation of antigen processing and presentation (GO:0002579)4.21782400
28negative regulation of T cell mediated immunity (GO:0002710)4.19087990
29* interferon-gamma-mediated signaling pathway (GO:0060333)4.18115645
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.15413481
31response to host immune response (GO:0052572)4.15413481
32positive regulation of interferon-beta production (GO:0032728)4.09951559
33negative regulation of interleukin-12 production (GO:0032695)4.06620860
34regulation of type I interferon-mediated signaling pathway (GO:0060338)3.98690182
35detection of other organism (GO:0098543)3.94376375
36* negative regulation of viral genome replication (GO:0045071)3.93988728
37detection of bacterium (GO:0016045)3.87069190
38regulation of T-helper 1 cell differentiation (GO:0045625)3.85304202
39* regulation of viral genome replication (GO:0045069)3.84289099
40cellular response to interferon-beta (GO:0035458)3.79123866
41response to interferon-beta (GO:0035456)3.77432641
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.76386690
43regulation of RIG-I signaling pathway (GO:0039535)3.75745761
44response to host (GO:0075136)3.71363404
45response to host defenses (GO:0052200)3.71363404
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.71363404
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.68953691
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.67741840
49regulation of antigen processing and presentation (GO:0002577)3.65277687
50positive regulation of natural killer cell differentiation (GO:0032825)3.63628795
51regulation of type 2 immune response (GO:0002828)3.61369436
52T-helper 1 type immune response (GO:0042088)3.60077346
53respiratory burst (GO:0045730)3.58967494
54granulocyte activation (GO:0036230)3.58933102
55* negative regulation of viral process (GO:0048525)3.58326647
56natural killer cell activation involved in immune response (GO:0002323)3.58203112
57T cell migration (GO:0072678)3.57026542
58macrophage activation involved in immune response (GO:0002281)3.55963283
59B cell mediated immunity (GO:0019724)3.55415958
60positive regulation of chemokine biosynthetic process (GO:0045080)3.50008128
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.49725084
62neutrophil activation (GO:0042119)3.48975893
63response to exogenous dsRNA (GO:0043330)3.46744899
64positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.46377393
65defense response to protozoan (GO:0042832)3.45486529
66natural killer cell mediated immunity (GO:0002228)3.42590002
67natural killer cell mediated cytotoxicity (GO:0042267)3.42590002
68positive regulation of interleukin-17 production (GO:0032740)3.42440651
69positive regulation of interleukin-12 production (GO:0032735)3.39917361
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.39041710
71* cellular response to interferon-gamma (GO:0071346)3.37742466
72negative regulation of type 2 immune response (GO:0002829)3.37007945
73negative regulation of cytokine production involved in immune response (GO:0002719)3.35614849
74positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.31598600
75regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.31598600
76NIK/NF-kappaB signaling (GO:0038061)3.27139841
77antigen processing and presentation via MHC class Ib (GO:0002475)3.26379635
78response to muramyl dipeptide (GO:0032495)3.25724573
79regulation of B cell receptor signaling pathway (GO:0050855)3.25529832
80myeloid dendritic cell differentiation (GO:0043011)3.25464848
81regulation of T cell tolerance induction (GO:0002664)3.24817136
82detection of external biotic stimulus (GO:0098581)3.23996721
83cellular response to interferon-alpha (GO:0035457)3.23526307
84regulation of alpha-beta T cell proliferation (GO:0046640)3.19680882
85leukocyte aggregation (GO:0070486)3.16490744
86positive regulation of type 2 immune response (GO:0002830)3.16329352
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14514736
88regulation of interleukin-17 production (GO:0032660)3.13747210
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13324825
90* defense response to virus (GO:0051607)3.12882213
91interferon-gamma secretion (GO:0072643)3.11998375
92detection of molecule of bacterial origin (GO:0032490)3.11153239
93regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.10555639
94myeloid dendritic cell activation (GO:0001773)3.10024188
95negative regulation of innate immune response (GO:0045824)3.09820536
96negative regulation of myeloid cell apoptotic process (GO:0033033)3.09536330
97myeloid cell activation involved in immune response (GO:0002275)3.09028812
98positive regulation of humoral immune response (GO:0002922)3.08958712
99response to protozoan (GO:0001562)3.08630880
100regulation of interferon-beta production (GO:0032648)3.08167558
101germinal center formation (GO:0002467)3.08117941
102negative regulation of leukocyte mediated immunity (GO:0002704)3.06882081
103* response to interferon-gamma (GO:0034341)3.06599682
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04277127
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03758855
106negative regulation of type I interferon production (GO:0032480)3.02160689
107positive regulation of toll-like receptor signaling pathway (GO:0034123)3.00368760
108regulation of activation of Janus kinase activity (GO:0010533)3.00027851
109response to interleukin-15 (GO:0070672)2.99996159
110lymphocyte migration (GO:0072676)2.98979460
111regulation of chemokine biosynthetic process (GO:0045073)2.98528059
112positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96961942
113lymphocyte chemotaxis (GO:0048247)2.96016696
114regulation of response to interferon-gamma (GO:0060330)2.95005665
115positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94349409
116cellular response to exogenous dsRNA (GO:0071360)2.93784579
117regulation of gamma-delta T cell activation (GO:0046643)2.93675747
118regulation of tolerance induction (GO:0002643)2.90557129
119positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.90510914
120regulation of interleukin-12 production (GO:0032655)2.89810603
121microglial cell activation (GO:0001774)2.89359716
122positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.88803553
123cellular response to zinc ion (GO:0071294)2.88761683
124negative thymic T cell selection (GO:0045060)2.87701263
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87220161
126negative regulation of interleukin-17 production (GO:0032700)2.85413714
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84239067
128regulation of defense response to virus by host (GO:0050691)2.83574974
129regulation of toll-like receptor signaling pathway (GO:0034121)2.83126659
130positive regulation of defense response to virus by host (GO:0002230)2.83052781
131regulation of T cell cytokine production (GO:0002724)2.82916063
132negative regulation of defense response to virus (GO:0050687)2.82566326
133positive regulation of cytokine biosynthetic process (GO:0042108)2.81657828
134regulation of interferon-gamma biosynthetic process (GO:0045072)2.81274060
135B cell proliferation (GO:0042100)2.80050287
136positive regulation of response to biotic stimulus (GO:0002833)2.79572736
137positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78585672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.73187706
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.08813721
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.44571396
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.27420743
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.63131217
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.59273588
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.16763154
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.64243697
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54089511
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41586931
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36960371
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.32255198
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13007572
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92572888
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76966225
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74297708
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.57937746
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.34321954
19MYB_26560356_Chip-Seq_TH2_Human2.12138007
20* SPI1_23547873_ChIP-Seq_NB4_Human2.08120462
21MAF_26560356_Chip-Seq_TH1_Human1.96332046
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93170070
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91463631
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90186316
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86074525
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84465730
27SCL_19346495_ChIP-Seq_HPC-7_Human1.80710534
28MYB_26560356_Chip-Seq_TH1_Human1.75607394
29RUNX_20019798_ChIP-Seq_JUKART_Human1.73152376
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71892909
31* RUNX1_22412390_ChIP-Seq_EML_Mouse1.71887984
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64541382
33VDR_24763502_ChIP-Seq_THP-1_Human1.64400553
34GATA1_22025678_ChIP-Seq_K562_Human1.64199735
35CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63398758
36PU_27001747_Chip-Seq_BMDM_Mouse1.61987097
37VDR_21846776_ChIP-Seq_THP-1_Human1.60248955
38SPI1_23127762_ChIP-Seq_K562_Human1.59983265
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59600780
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58711532
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55578818
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52049151
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51476645
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40889451
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40450611
46UTX_26944678_Chip-Seq_JUKART_Human1.34914918
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32893840
48* LXR_22292898_ChIP-Seq_THP-1_Human1.28960466
49VDR_24787735_ChIP-Seq_THP-1_Human1.28913592
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28181040
51GATA3_27048872_Chip-Seq_THYMUS_Human1.27435450
52GATA3_26560356_Chip-Seq_TH2_Human1.25244743
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24738218
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21964161
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21120822
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.19633443
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16787409
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16018492
59* MAF_26560356_Chip-Seq_TH2_Human1.15994457
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13209783
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12615344
62E2F7_22180533_ChIP-Seq_HELA_Human1.11613157
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.10470943
64* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05753166
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.05212213
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05090828
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03816336
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03177860
69TCF7_22412390_ChIP-Seq_EML_Mouse1.01196641
70RACK7_27058665_Chip-Seq_MCF-7_Human1.00484969
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00066049
72MYC_22102868_ChIP-Seq_BL_Human1.00000283
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99290787
74EGR1_19032775_ChIP-ChIP_M12_Human0.98761780
75* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92744584
76KDM2B_26808549_Chip-Seq_JURKAT_Human0.92499951
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90476138
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89879284
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86551513
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.85913400
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84966566
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84614898
83GATA1_19941826_ChIP-Seq_K562_Human0.84603087
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83274004
85ESR2_21235772_ChIP-Seq_MCF-7_Human0.80562568
86* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80216518
87NCOR1_26117541_ChIP-Seq_K562_Human0.77244359
88BCOR_27268052_Chip-Seq_Bcells_Human0.77003318
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76370794
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75624409
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75334590
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73467593
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71934512
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.71366113
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70999422
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70504357
97CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69048269
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68775310
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68373126
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.67465509
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.67248654
102ELF1_17652178_ChIP-ChIP_JURKAT_Human0.65675737
103GATA2_19941826_ChIP-Seq_K562_Human0.65057675
104KDM2B_26808549_Chip-Seq_DND41_Human0.63980330
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62814497
106* SOX2_20726797_ChIP-Seq_SW620_Human0.62535525
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.61489072
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.60794263
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.60386335
110SPI1_20517297_ChIP-Seq_HL60_Human0.59360404
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58550395
112CTCF_26484167_Chip-Seq_Bcells_Mouse0.58514480
113KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.57944646
114BCL6_27268052_Chip-Seq_Bcells_Human0.56997489
115HOXB4_20404135_ChIP-ChIP_EML_Mouse0.56581380
116TFEB_21752829_ChIP-Seq_HELA_Human0.56575254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.99255474
2MP0009785_altered_susceptibility_to4.20827968
3MP0003436_decreased_susceptibility_to3.68189753
4MP0000685_abnormal_immune_system3.51398309
5MP0005387_immune_system_phenotype3.38601430
6MP0001790_abnormal_immune_system3.38601430
7MP0005671_abnormal_response_to3.36355286
8MP0002148_abnormal_hypersensitivity_rea3.28250915
9MP0005025_abnormal_response_to3.23802529
10MP0005000_abnormal_immune_tolerance3.22588293
11MP0006082_CNS_inflammation3.07545052
12MP0002419_abnormal_innate_immunity2.96077761
13MP0003303_peritoneal_inflammation2.88883167
14MP0003724_increased_susceptibility_to2.87891771
15MP0004510_myositis2.87185274
16MP0001800_abnormal_humoral_immune2.85087478
17MP0002452_abnormal_antigen_presenting2.78421472
18MP0002723_abnormal_immune_serum2.76324681
19MP0001819_abnormal_immune_cell2.52245787
20MP0002420_abnormal_adaptive_immunity2.47803607
21MP0005058_abnormal_lysosome_morphology2.17711324
22MP0004947_skin_inflammation2.11872462
23MP0002166_altered_tumor_susceptibility2.03433328
24MP0001533_abnormal_skeleton_physiology2.02054920
25MP0005451_abnormal_body_composition2.01865807
26MP0002006_tumorigenesis1.99270412
27MP0002405_respiratory_system_inflammati1.97357957
28MP0005464_abnormal_platelet_physiology1.93749697
29MP0002398_abnormal_bone_marrow1.93636134
30MP0000716_abnormal_immune_system1.92195735
31MP0010155_abnormal_intestine_physiology1.88744303
32MP0001845_abnormal_inflammatory_respons1.87210988
33MP0005310_abnormal_salivary_gland1.84208858
34MP0001853_heart_inflammation1.78257881
35MP0003763_abnormal_thymus_physiology1.76041849
36MP0008469_abnormal_protein_level1.74580270
37MP0003448_altered_tumor_morphology1.74458993
38MP0009764_decreased_sensitivity_to1.72616771
39MP0009333_abnormal_splenocyte_physiolog1.72100956
40MP0003172_abnormal_lysosome_physiology1.69371625
41MP0009278_abnormal_bone_marrow1.61238799
42MP0002429_abnormal_blood_cell1.55628994
43MP0000689_abnormal_spleen_morphology1.54780946
44MP0003191_abnormal_cellular_cholesterol1.52633345
45MP0002722_abnormal_immune_system1.47545745
46MP0005397_hematopoietic_system_phenotyp1.44952707
47MP0001545_abnormal_hematopoietic_system1.44952707
48MP0010307_abnormal_tumor_latency1.43596693
49MP0000343_altered_response_to1.37357197
50MP0009840_abnormal_foam_cell1.35842153
51MP0001873_stomach_inflammation1.34044099
52MP0000858_altered_metastatic_potential1.32723713
53MP0003300_gastrointestinal_ulcer1.31491054
54MP0003075_altered_response_to1.27008322
55MP0003183_abnormal_peptide_metabolism1.24855105
56MP0004782_abnormal_surfactant_physiolog1.22880226
57MP0002998_abnormal_bone_remodeling1.22635775
58MP0002933_joint_inflammation1.16462143
59MP0000604_amyloidosis1.08795281
60MP0004808_abnormal_hematopoietic_stem1.07307586
61MP0005174_abnormal_tail_pigmentation1.06697734
62MP0000569_abnormal_digit_pigmentation1.06637480
63MP0002277_abnormal_respiratory_mucosa1.04922884
64MP0002396_abnormal_hematopoietic_system1.04777040
65MP0002138_abnormal_hepatobiliary_system1.03218974
66MP0000703_abnormal_thymus_morphology0.99076653
67MP0005166_decreased_susceptibility_to0.96505191
68MP0003221_abnormal_cardiomyocyte_apopto0.92583746
69MP0009763_increased_sensitivity_to0.91042268
70MP0004858_abnormal_nervous_system0.90608687
71MP0005390_skeleton_phenotype0.89423123
72MP0004381_abnormal_hair_follicle0.88753647
73MP0000490_abnormal_crypts_of0.87665133
74MP0002332_abnormal_exercise_endurance0.87366312
75MP0003866_abnormal_defecation0.86962559
76MP0004883_abnormal_blood_vessel0.86096270
77MP0005167_abnormal_blood-brain_barrier0.85833945
78MP0003656_abnormal_erythrocyte_physiolo0.84913994
79MP0002877_abnormal_melanocyte_morpholog0.84028547
80MP0003806_abnormal_nucleotide_metabolis0.79424263
81MP0001348_abnormal_lacrimal_gland0.79284439
82MP0002132_abnormal_respiratory_system0.75568872
83MP0001851_eye_inflammation0.74944642
84MP0008874_decreased_physiological_sensi0.73803266
85MP0008260_abnormal_autophagy0.71962973
86MP0005164_abnormal_response_to0.71857793
87MP0002163_abnormal_gland_morphology0.71649749
88MP0005076_abnormal_cell_differentiation0.71583650
89MP0003186_abnormal_redox_activity0.69371858
90MP0000015_abnormal_ear_pigmentation0.68506125
91MP0008004_abnormal_stomach_pH0.68414931
92MP0003705_abnormal_hypodermis_morpholog0.67638517
93MP0003091_abnormal_cell_migration0.66203115
94MP0000465_gastrointestinal_hemorrhage0.65953425
95MP0003453_abnormal_keratinocyte_physiol0.65401096
96MP0000249_abnormal_blood_vessel0.61608919
97MP0005023_abnormal_wound_healing0.60559964
98MP0003566_abnormal_cell_adhesion0.60248063
99MP0001663_abnormal_digestive_system0.59251875
100MP0003795_abnormal_bone_structure0.58612463
101MP0000920_abnormal_myelination0.57657235
102MP0001881_abnormal_mammary_gland0.57414328
103MP0003690_abnormal_glial_cell0.57270097
104MP0010352_gastrointestinal_tract_polyps0.56859160
105MP0002136_abnormal_kidney_physiology0.55058223
106MP0002019_abnormal_tumor_incidence0.54853982
107MP0005621_abnormal_cell_physiology0.54372913
108MP0001216_abnormal_epidermal_layer0.53266696
109MP0003828_pulmonary_edema0.52453478
110MP0003045_fibrosis0.52216174
111MP0000609_abnormal_liver_physiology0.51616618
112MP0009765_abnormal_xenobiotic_induced0.51133656
113MP0002693_abnormal_pancreas_physiology0.48074823
114MP0000371_diluted_coat_color0.46417353
115MP0002254_reproductive_system_inflammat0.44587883

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.24877002
2Recurrent abscess formation (HP:0002722)6.14680257
3Recurrent bacterial skin infections (HP:0005406)5.60699845
4Elevated erythrocyte sedimentation rate (HP:0003565)5.53935567
5Chronic otitis media (HP:0000389)5.45124101
6Myositis (HP:0100614)5.08456109
7Autoimmune thrombocytopenia (HP:0001973)4.86399811
8Abnormality of macrophages (HP:0004311)4.78512207
9Orchitis (HP:0100796)4.65796501
10Recurrent gram-negative bacterial infections (HP:0005420)4.65183028
11Retrobulbar optic neuritis (HP:0100654)4.58042674
12Optic neuritis (HP:0100653)4.58042674
13Recurrent fungal infections (HP:0002841)4.23532339
14Mediastinal lymphadenopathy (HP:0100721)4.19090170
15Vasculitis (HP:0002633)4.05586111
16Increased IgM level (HP:0003496)4.04018389
17Nasal polyposis (HP:0100582)3.98819502
18Recurrent viral infections (HP:0004429)3.83418140
19Stomatitis (HP:0010280)3.79573424
20Recurrent skin infections (HP:0001581)3.77310411
21Vacuolated lymphocytes (HP:0001922)3.67981971
22Basal ganglia calcification (HP:0002135)3.66826185
23Recurrent bronchitis (HP:0002837)3.56654628
24Abnormality of the nasal mucosa (HP:0000433)3.55276000
25Chronic obstructive pulmonary disease (HP:0006510)3.51650618
26Obstructive lung disease (HP:0006536)3.51650618
27Gingivitis (HP:0000230)3.44660775
28Increased cerebral lipofuscin (HP:0011813)3.31374417
29Systemic lupus erythematosus (HP:0002725)3.30942188
30Recurrent cutaneous fungal infections (HP:0011370)3.28749357
31Chronic mucocutaneous candidiasis (HP:0002728)3.28749357
32Pustule (HP:0200039)3.19456327
33Hypergammaglobulinemia (HP:0010702)3.17650465
34Chronic sinusitis (HP:0011109)3.02414006
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.99416754
36Pulmonary infiltrates (HP:0002113)2.96137882
37Interstitial pulmonary disease (HP:0006530)2.94376015
38Prostate neoplasm (HP:0100787)2.90196603
39Autoimmune hemolytic anemia (HP:0001890)2.84317483
40Petechiae (HP:0000967)2.83544761
41Meningitis (HP:0001287)2.82213187
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.82144317
43Hemoptysis (HP:0002105)2.79724745
44Abnormality of T cell number (HP:0011839)2.78610119
45Keratoconjunctivitis sicca (HP:0001097)2.75838276
46Periodontitis (HP:0000704)2.71106352
47Loss of speech (HP:0002371)2.70050929
48Arterial thrombosis (HP:0004420)2.69923544
49Increased IgE level (HP:0003212)2.66134343
50Urticaria (HP:0001025)2.64982008
51Leukocytosis (HP:0001974)2.64499990
52Abnormality of the endocardium (HP:0004306)2.63561547
53Cellulitis (HP:0100658)2.62286352
54Abnormality of T cells (HP:0002843)2.61324717
55Gingival bleeding (HP:0000225)2.58386189
56Agammaglobulinemia (HP:0004432)2.57836342
57Gangrene (HP:0100758)2.55910685
58Abnormality of T cell physiology (HP:0011840)2.53687802
59Keratoconjunctivitis (HP:0001096)2.53604446
60Gastrointestinal infarctions (HP:0005244)2.51119872
61T lymphocytopenia (HP:0005403)2.48596290
62Spontaneous hematomas (HP:0007420)2.48173848
63Tetraparesis (HP:0002273)2.47895805
64Porencephaly (HP:0002132)2.47681510
65Panhypogammaglobulinemia (HP:0003139)2.46363688
66Recurrent pneumonia (HP:0006532)2.43908446
67Abnormality of glycolipid metabolism (HP:0010969)2.40565435
68Abnormality of liposaccharide metabolism (HP:0010968)2.40565435
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.40565435
70Eosinophilia (HP:0001880)2.40167620
71IgM deficiency (HP:0002850)2.35833197
72Anorexia (HP:0002039)2.34777813
73Inflammation of the large intestine (HP:0002037)2.33361706
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.32136923
75Joint swelling (HP:0001386)2.31985323
76Emphysema (HP:0002097)2.30381170
77Pulmonary embolism (HP:0002204)2.28060390
78Lymphopenia (HP:0001888)2.27618320
79Recurrent lower respiratory tract infections (HP:0002783)2.26813289
80Encephalitis (HP:0002383)2.25899754
81Peritonitis (HP:0002586)2.24885509
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24486565
83Disinhibition (HP:0000734)2.24034345
84Osteomyelitis (HP:0002754)2.22410562
85Gastrointestinal inflammation (HP:0004386)2.21032930
86Premature loss of primary teeth (HP:0006323)2.20800827
87IgA deficiency (HP:0002720)2.20413812
88Dysostosis multiplex (HP:0000943)2.19459017
89IgG deficiency (HP:0004315)2.19382158
90Hepatosplenomegaly (HP:0001433)2.17677455
91Cheilitis (HP:0100825)2.14951045
92Granulocytopenia (HP:0001913)2.13422495
93Skin rash (HP:0000988)2.12832099
94Glomerulopathy (HP:0100820)2.12091117
95Axonal loss (HP:0003447)2.11699732
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11007336
97Abnormality of the prostate (HP:0008775)2.10992144
98Sepsis (HP:0100806)2.10653685
99Abnormality of eosinophils (HP:0001879)2.10113201
100Abnormality of the peritoneum (HP:0002585)2.08408225
101Arthralgia (HP:0002829)2.06461917
102Epistaxis (HP:0000421)2.05539759
103Skin ulcer (HP:0200042)2.05361771
104Chronic diarrhea (HP:0002028)2.05298008
105Colitis (HP:0002583)2.04966999
106Chest pain (HP:0100749)2.04165806
107Fatigue (HP:0012378)2.03682846
108Abnormality of the pleura (HP:0002103)2.03323959
109Purpura (HP:0000979)1.99618921
110Viral hepatitis (HP:0006562)1.99096910
111Restrictive lung disease (HP:0002091)1.98496736
112Thick nail (HP:0001805)1.98003578
113Malnutrition (HP:0004395)1.97271949
114Thrombocytosis (HP:0001894)1.97153866
115Hypochromic anemia (HP:0001931)1.95956729
116Hematochezia (HP:0002573)1.95675749
117Keratitis (HP:0000491)1.95407751
118Acute hepatic failure (HP:0006554)1.94201002
119Gastrointestinal stroma tumor (HP:0100723)1.92882510
120Abnormality of the pericardium (HP:0001697)1.92726275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK14.79342860
2IKBKE4.24095530
3MAP3K144.15541156
4TYK24.13599528
5MAP4K13.42554527
6JAK33.15109488
7BLK3.04378008
8IRAK42.93553013
9PRPF4B2.86313183
10KIT2.85557873
11TXK2.61805583
12JAK12.52978628
13IKBKB2.45109765
14RIPK42.27719839
15FGFR42.16136773
16MAP3K132.03355700
17IRAK31.95960954
18PIM21.93276158
19ZAP701.81431939
20ERN11.78033402
21PBK1.75702611
22CSK1.61187821
23SYK1.54785488
24EPHB11.51764681
25FGFR31.50099610
26HCK1.43687094
27SMG11.43331606
28CHUK1.40513353
29BTK1.37481847
30LCK1.25735852
31GRK71.23457174
32FES1.22377287
33CSF1R1.21129333
34SIK11.21031967
35NME21.15823862
36TAOK31.14013831
37EPHA31.12757824
38ARAF1.12338798
39TEC1.12114752
40PIM11.10634963
41GRK61.07802162
42LYN1.06173336
43STK101.05040996
44CDC42BPA1.03397413
45SIK31.02794540
46RPS6KA41.01074546
47TAOK21.00311002
48JAK20.96751809
49MST40.95826437
50TAOK10.89717127
51FGR0.83028995
52NEK90.82625006
53STK40.81675963
54MARK30.81416859
55HIPK20.79769496
56EIF2AK20.78198723
57ITK0.78151174
58SIK20.69092939
59BMX0.69011598
60TGFBR20.68560239
61DDR20.67591567
62NLK0.66389151
63MATK0.65645476
64PRKD20.65384117
65BMPR20.63449985
66PRKCQ0.62806876
67IRAK20.61812642
68MAP3K110.61695416
69MAPK70.59908874
70IRAK10.57527682
71MAP3K50.56773014
72PRKCD0.55078853
73TRPM70.53904333
74ABL10.50556629
75PTK60.50541015
76KSR20.49234116
77RPS6KA50.48262948
78KDR0.48170259
79EGFR0.47912847
80LRRK20.47337472
81ABL20.45945722
82CLK10.43739575
83MARK20.42579151
84MAPK110.39985363
85MAP2K30.39903707
86ADRBK20.39043465
87YES10.38638191
88CDK40.38195169
89TESK20.36584102
90PRKG20.36315731
91MAPKAPK20.36198606
92MAP3K120.35133502
93MST1R0.34000351
94RPS6KA60.33698524
95NUAK10.33262616
96PDK10.32772345
97MELK0.32046815
98MOS0.31708729
99TNK20.31543769
100MAP3K10.31518554
101CDK120.30909415
102TGFBR10.29835226
103PKN10.29776819
104PDPK10.29295070
105MAP3K60.28130426
106TESK10.27607547
107FLT30.26808238
108TRIB30.26138919
109FYN0.24943554
110ICK0.24579957
111RIPK10.23614435
112PKN20.22601754
113PRKCH0.21963737
114CDK60.21602064
115RPS6KA10.21581514
116STK240.21000016
117TTN0.20706322
118IGF1R0.20168467
119MAP3K80.19934600
120RET0.19504189
121MAPK30.19433013
122MAP3K30.19045686
123RPS6KC10.19006075

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.14617185
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.06062139
3Allograft rejection_Homo sapiens_hsa053303.00650845
4Graft-versus-host disease_Homo sapiens_hsa053322.99471509
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.93929333
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.84004591
7* Measles_Homo sapiens_hsa051622.70581764
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.66738197
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.44072953
10Osteoclast differentiation_Homo sapiens_hsa043802.20689249
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19327033
12* Influenza A_Homo sapiens_hsa051642.16285973
13Staphylococcus aureus infection_Homo sapiens_hsa051502.15689841
14Primary immunodeficiency_Homo sapiens_hsa053402.10643525
15Pertussis_Homo sapiens_hsa051332.08779759
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03080088
17* Herpes simplex infection_Homo sapiens_hsa051682.01040847
18Antigen processing and presentation_Homo sapiens_hsa046121.98034172
19Malaria_Homo sapiens_hsa051441.95355457
20Legionellosis_Homo sapiens_hsa051341.91160125
21Tuberculosis_Homo sapiens_hsa051521.83943237
22TNF signaling pathway_Homo sapiens_hsa046681.83524471
23Type I diabetes mellitus_Homo sapiens_hsa049401.74880466
24Toxoplasmosis_Homo sapiens_hsa051451.69876165
25Asthma_Homo sapiens_hsa053101.66954848
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65796360
27Rheumatoid arthritis_Homo sapiens_hsa053231.62595843
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.62490551
29B cell receptor signaling pathway_Homo sapiens_hsa046621.60183836
30Autoimmune thyroid disease_Homo sapiens_hsa053201.56564811
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44871603
32Chemokine signaling pathway_Homo sapiens_hsa040621.44341225
33Salmonella infection_Homo sapiens_hsa051321.43225874
34African trypanosomiasis_Homo sapiens_hsa051431.43102516
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40870237
36Hematopoietic cell lineage_Homo sapiens_hsa046401.40328977
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39891713
38Apoptosis_Homo sapiens_hsa042101.39890952
39Hepatitis B_Homo sapiens_hsa051611.37683803
40* Hepatitis C_Homo sapiens_hsa051601.36270172
41Viral myocarditis_Homo sapiens_hsa054161.31762039
42Shigellosis_Homo sapiens_hsa051311.28372418
43Lysosome_Homo sapiens_hsa041421.25845080
44T cell receptor signaling pathway_Homo sapiens_hsa046601.23707003
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21765502
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.14535872
47Other glycan degradation_Homo sapiens_hsa005111.07839210
48Phagosome_Homo sapiens_hsa041451.01033029
49Acute myeloid leukemia_Homo sapiens_hsa052210.96534643
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92365175
51Caffeine metabolism_Homo sapiens_hsa002320.90850353
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.85872002
53Prolactin signaling pathway_Homo sapiens_hsa049170.82789232
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81094532
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78029088
56Pancreatic cancer_Homo sapiens_hsa052120.76786449
57Epstein-Barr virus infection_Homo sapiens_hsa051690.69434284
58Viral carcinogenesis_Homo sapiens_hsa052030.67647478
59Chronic myeloid leukemia_Homo sapiens_hsa052200.66803917
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65336200
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65151577
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63756509
63Bladder cancer_Homo sapiens_hsa052190.61256666
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59755585
65Amoebiasis_Homo sapiens_hsa051460.58991676
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55562438
67Renal cell carcinoma_Homo sapiens_hsa052110.55021784
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53323599
69Mineral absorption_Homo sapiens_hsa049780.52048136
70Small cell lung cancer_Homo sapiens_hsa052220.50033992
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49912318
72Platelet activation_Homo sapiens_hsa046110.49549177
73HIF-1 signaling pathway_Homo sapiens_hsa040660.49526970
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.47581497
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45915354
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.44007534
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43640717
78Dorso-ventral axis formation_Homo sapiens_hsa043200.42451853
79HTLV-I infection_Homo sapiens_hsa051660.41503072
80Notch signaling pathway_Homo sapiens_hsa043300.40593924
81Endometrial cancer_Homo sapiens_hsa052130.38671070
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37663959
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35116996
84VEGF signaling pathway_Homo sapiens_hsa043700.34609123
85ABC transporters_Homo sapiens_hsa020100.34453643
86Prostate cancer_Homo sapiens_hsa052150.34214909
87mTOR signaling pathway_Homo sapiens_hsa041500.33694741
88p53 signaling pathway_Homo sapiens_hsa041150.33138739
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.32926996
90Proteasome_Homo sapiens_hsa030500.32655188
91Type II diabetes mellitus_Homo sapiens_hsa049300.32161427
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.31312428
93GnRH signaling pathway_Homo sapiens_hsa049120.28093719
94ErbB signaling pathway_Homo sapiens_hsa040120.25761865
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25261264
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23358655
97MAPK signaling pathway_Homo sapiens_hsa040100.23291972
98Prion diseases_Homo sapiens_hsa050200.23011525
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22889530
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22238828
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.21574723
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21397716
103Choline metabolism in cancer_Homo sapiens_hsa052310.20627275
104Endocytosis_Homo sapiens_hsa041440.19357270
105Systemic lupus erythematosus_Homo sapiens_hsa053220.19311228
106Sphingolipid metabolism_Homo sapiens_hsa006000.19196370
107FoxO signaling pathway_Homo sapiens_hsa040680.15638681
108Insulin resistance_Homo sapiens_hsa049310.11769631
109Inositol phosphate metabolism_Homo sapiens_hsa005620.11549294
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11345940
111MicroRNAs in cancer_Homo sapiens_hsa052060.11310244
112Non-small cell lung cancer_Homo sapiens_hsa052230.11206048
113Galactose metabolism_Homo sapiens_hsa000520.11126020
114Proteoglycans in cancer_Homo sapiens_hsa052050.11061485
115Colorectal cancer_Homo sapiens_hsa052100.09428048
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07969979

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