OAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.21346276
2L-phenylalanine catabolic process (GO:0006559)6.91201260
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.91201260
4L-phenylalanine metabolic process (GO:0006558)6.73345505
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.73345505
6NADH metabolic process (GO:0006734)6.54255648
7aromatic amino acid family catabolic process (GO:0009074)6.18621555
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.77751353
9regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.76486999
10regulation of guanylate cyclase activity (GO:0031282)5.67187789
11tryptophan catabolic process (GO:0006569)5.54178979
12indole-containing compound catabolic process (GO:0042436)5.54178979
13indolalkylamine catabolic process (GO:0046218)5.54178979
14urea cycle (GO:0000050)5.51744330
15urea metabolic process (GO:0019627)5.51744330
16kynurenine metabolic process (GO:0070189)5.51078783
17alpha-linolenic acid metabolic process (GO:0036109)5.45684760
18bile acid biosynthetic process (GO:0006699)5.40914098
19sulfur amino acid catabolic process (GO:0000098)5.37837022
20cysteine metabolic process (GO:0006534)5.36330119
21glyoxylate metabolic process (GO:0046487)5.32797555
22homocysteine metabolic process (GO:0050667)5.28469017
23intestinal absorption (GO:0050892)5.25692044
24tryptophan metabolic process (GO:0006568)5.23267492
25nitrogen cycle metabolic process (GO:0071941)5.06078134
26lysine metabolic process (GO:0006553)5.04341662
27lysine catabolic process (GO:0006554)5.04341662
28lipoprotein transport (GO:0042953)5.04177637
29protein carboxylation (GO:0018214)4.92395878
30peptidyl-glutamic acid carboxylation (GO:0017187)4.92395878
31negative regulation of fibrinolysis (GO:0051918)4.91433705
32high-density lipoprotein particle remodeling (GO:0034375)4.90148923
33fructose metabolic process (GO:0006000)4.87055593
34serine family amino acid catabolic process (GO:0009071)4.74491321
35regulation of protein activation cascade (GO:2000257)4.73921362
36complement activation, alternative pathway (GO:0006957)4.73270855
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.67073225
38regulation of fibrinolysis (GO:0051917)4.66679495
39regulation of triglyceride catabolic process (GO:0010896)4.58588001
40bile acid metabolic process (GO:0008206)4.57853112
41amino-acid betaine metabolic process (GO:0006577)4.57260426
42aromatic amino acid family metabolic process (GO:0009072)4.55863082
43fat-soluble vitamin biosynthetic process (GO:0042362)4.53041142
44tyrosine metabolic process (GO:0006570)4.50825225
45regulation of complement activation (GO:0030449)4.47454670
46cellular ketone body metabolic process (GO:0046950)4.42920658
47alpha-amino acid catabolic process (GO:1901606)4.42375007
48positive regulation of guanylate cyclase activity (GO:0031284)4.40974970
49regulation of cholesterol esterification (GO:0010872)4.35636228
50reverse cholesterol transport (GO:0043691)4.35578561
51triglyceride homeostasis (GO:0070328)4.35000590
52acylglycerol homeostasis (GO:0055090)4.35000590
53cellular glucuronidation (GO:0052695)4.27036749
54ethanol oxidation (GO:0006069)4.24713880
55plasma lipoprotein particle remodeling (GO:0034369)4.24169592
56protein-lipid complex remodeling (GO:0034368)4.24169592
57macromolecular complex remodeling (GO:0034367)4.24169592
58negative regulation of cholesterol transport (GO:0032375)4.19790745
59negative regulation of sterol transport (GO:0032372)4.19790745
60glycine metabolic process (GO:0006544)4.16417752
61cellular amino acid catabolic process (GO:0009063)4.13825298
62hormone catabolic process (GO:0042447)4.13074288
63serine family amino acid biosynthetic process (GO:0009070)4.08109827
64serine family amino acid metabolic process (GO:0009069)4.06754884
65cellular modified amino acid catabolic process (GO:0042219)4.02671799
66glutamate metabolic process (GO:0006536)4.01616077
67COPI coating of Golgi vesicle (GO:0048205)3.98267424
68Golgi transport vesicle coating (GO:0048200)3.98267424
69bile acid and bile salt transport (GO:0015721)3.98224107
70coenzyme catabolic process (GO:0009109)3.96930651
71ketone body metabolic process (GO:1902224)3.94352701
72phospholipid efflux (GO:0033700)3.93974580
73aldehyde catabolic process (GO:0046185)3.92545186
74plasma lipoprotein particle clearance (GO:0034381)3.92439459
75benzene-containing compound metabolic process (GO:0042537)3.91800764
76COPII vesicle coating (GO:0048208)3.89905931
77epoxygenase P450 pathway (GO:0019373)3.89116086
78arginine metabolic process (GO:0006525)3.86680226
79indolalkylamine metabolic process (GO:0006586)3.86572176
80drug catabolic process (GO:0042737)3.86342709
81glucuronate metabolic process (GO:0019585)3.85443273
82uronic acid metabolic process (GO:0006063)3.85443273
83short-chain fatty acid metabolic process (GO:0046459)3.85032751
84ethanol metabolic process (GO:0006067)3.79927923
85regulation of bile acid biosynthetic process (GO:0070857)3.79079860
86aspartate family amino acid catabolic process (GO:0009068)3.78386707
87amine catabolic process (GO:0009310)3.76315181
88cellular biogenic amine catabolic process (GO:0042402)3.76315181
89imidazole-containing compound metabolic process (GO:0052803)3.75078027
90cholesterol efflux (GO:0033344)3.74034531
91dicarboxylic acid biosynthetic process (GO:0043650)3.72681950
922-oxoglutarate metabolic process (GO:0006103)3.72123621
93acetyl-CoA metabolic process (GO:0006084)3.70832844
94plasma lipoprotein particle assembly (GO:0034377)3.70507873
95protein-lipid complex assembly (GO:0065005)3.69596445
96carboxylic acid catabolic process (GO:0046395)3.68991739
97organic acid catabolic process (GO:0016054)3.68991739
98regulation of cholesterol homeostasis (GO:2000188)3.68312236
99positive regulation of glycoprotein biosynthetic process (GO:0010560)3.64420741
100very-low-density lipoprotein particle assembly (GO:0034379)3.62268114
101response to nitrosative stress (GO:0051409)3.61895687
102fatty acid beta-oxidation (GO:0006635)3.59652888
103low-density lipoprotein particle remodeling (GO:0034374)3.59307610
104flavonoid metabolic process (GO:0009812)3.59287850
105fibrinolysis (GO:0042730)3.57508529
106nucleoside diphosphate biosynthetic process (GO:0009133)3.56985957
107primary alcohol catabolic process (GO:0034310)3.54583489
108positive regulation of glycoprotein metabolic process (GO:1903020)3.53548439
109positive regulation of lipid catabolic process (GO:0050996)3.53307409
110cholesterol homeostasis (GO:0042632)3.53223065
111fatty acid oxidation (GO:0019395)3.51203029
112monocarboxylic acid catabolic process (GO:0072329)3.50538944
113carnitine metabolic process (GO:0009437)3.48723201
114cofactor catabolic process (GO:0051187)3.48705104
115vitamin transmembrane transport (GO:0035461)3.48154684
116phospholipid homeostasis (GO:0055091)3.48114604
117sterol homeostasis (GO:0055092)3.47745040
118drug metabolic process (GO:0017144)3.47000917
119adhesion of symbiont to host cell (GO:0044650)3.45357933
120virion attachment to host cell (GO:0019062)3.45357933
121regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.45318840
122endocrine process (GO:0050886)3.45318840
123regulation of systemic arterial blood pressure by hormone (GO:0001990)3.45318840
124nucleotide-sugar biosynthetic process (GO:0009226)3.44375580
125tricarboxylic acid cycle (GO:0006099)3.37636491
126regulation of systemic arterial blood pressure (GO:0003073)3.36798915
127peptide hormone processing (GO:0016486)3.31177383
128transcytosis (GO:0045056)3.31077285
129renal system process involved in regulation of blood volume (GO:0001977)3.30972542
130vitamin A metabolic process (GO:0006776)3.29761369
131sphingomyelin metabolic process (GO:0006684)3.28826880
132positive regulation of pseudopodium assembly (GO:0031274)3.24670096
133regulation of cGMP biosynthetic process (GO:0030826)3.24031589
134L-ascorbic acid metabolic process (GO:0019852)3.23709708
135cellular response to oxygen radical (GO:0071450)3.14144548
136removal of superoxide radicals (GO:0019430)3.14144548
137cellular response to superoxide (GO:0071451)3.14144548
138glycosphingolipid catabolic process (GO:0046479)3.08239038
139receptor guanylyl cyclase signaling pathway (GO:0007168)3.06233364
140glycolipid catabolic process (GO:0019377)3.05228662
141glycosylceramide metabolic process (GO:0006677)3.01722492
142oxaloacetate metabolic process (GO:0006107)3.00238577
143digestion (GO:0007586)2.98350592
144vitamin transport (GO:0051180)2.96512532
145zinc ion transport (GO:0006829)2.94908668
146* glutamine family amino acid biosynthetic process (GO:0009084)2.94689824
147heme transport (GO:0015886)2.93987200
148UDP-N-acetylglucosamine metabolic process (GO:0006047)2.93732424
149ribosome assembly (GO:0042255)2.93536093
150drinking behavior (GO:0042756)2.92589082
151cellular response to nitric oxide (GO:0071732)2.92472258
152vitamin biosynthetic process (GO:0009110)2.91994492
153proteasome assembly (GO:0043248)2.89086807
154cobalamin metabolic process (GO:0009235)2.88880619
155lipoprotein metabolic process (GO:0042157)2.86258599
156sphingolipid catabolic process (GO:0030149)2.85769391
157fat-soluble vitamin metabolic process (GO:0006775)2.85356147
158adhesion of symbiont to host (GO:0044406)2.83323315
159regulation of pseudopodium assembly (GO:0031272)2.83171295
160midgut development (GO:0007494)2.81857576
161peptide catabolic process (GO:0043171)2.79623119
162diacylglycerol metabolic process (GO:0046339)2.78671689
163desmosome organization (GO:0002934)2.76261509
164urate metabolic process (GO:0046415)2.71622224
165regulation of cGMP metabolic process (GO:0030823)2.69939710
166membrane lipid catabolic process (GO:0046466)2.69790582
167regulation of vitamin metabolic process (GO:0030656)2.69365616
168glycoside metabolic process (GO:0016137)2.68479224
169regulation of cellular extravasation (GO:0002691)2.68282388
170regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.68089541
171glycerol metabolic process (GO:0006071)2.65425064
172neutral amino acid transport (GO:0015804)2.62051992
173ceramide catabolic process (GO:0046514)2.60903280
174negative regulation of keratinocyte proliferation (GO:0010839)2.60174896
175regulation of protein glycosylation (GO:0060049)2.60125977
176cyclooxygenase pathway (GO:0019371)2.59430711
177actin filament depolymerization (GO:0030042)2.58513177
178negative regulation of steroid biosynthetic process (GO:0010894)2.57537575
179very long-chain fatty acid metabolic process (GO:0000038)2.56115102
180positive regulation of cellular amine metabolic process (GO:0033240)2.56110703
181regulation of transforming growth factor beta1 production (GO:0032908)2.54647173
182antibacterial humoral response (GO:0019731)2.54102992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.78800966
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.85780628
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.11195639
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.08440250
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.75803392
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.70394425
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66381996
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.62524852
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.56710600
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.48342065
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91502810
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51776582
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.47706208
14CLOCK_20551151_ChIP-Seq_293T_Human2.45921386
15PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.19122757
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09443056
17* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01171428
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2817036
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99947666
20E2F7_22180533_ChIP-Seq_HELA_Human1.86902905
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86302485
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85426131
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77231372
24GATA1_22025678_ChIP-Seq_K562_Human1.76513902
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74014173
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.72503057
27* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67343046
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59894511
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52101928
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.50407426
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49874556
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.47518073
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.47355970
34EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46064108
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40899180
36CDX2_22108803_ChIP-Seq_LS180_Human1.40508384
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37026808
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35894310
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35446085
40HNF4A_19822575_ChIP-Seq_HepG2_Human1.34503198
41* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33582363
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.32264009
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28618856
44* GATA4_25053715_ChIP-Seq_YYC3_Human1.26945315
45NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26820849
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26145548
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24935778
48DCP1A_22483619_ChIP-Seq_HELA_Human1.20872022
49* EOMES_21245162_ChIP-Seq_HESCs_Human1.19597331
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19570621
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17030525
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15084911
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14102291
54HTT_18923047_ChIP-ChIP_STHdh_Human1.13491048
55NANOG_18692474_ChIP-Seq_MEFs_Mouse1.13324772
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11454802
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11103049
58CDX2_20551321_ChIP-Seq_CACO-2_Human1.11099476
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10408204
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09759057
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09759057
62* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07453192
63ZNF263_19887448_ChIP-Seq_K562_Human1.06802072
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05451914
65ELK1_19687146_ChIP-ChIP_HELA_Human1.05420648
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05221001
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.04721722
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03632729
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02325545
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.02283371
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01392970
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01349078
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00646130
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.00201665
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98388844
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96927384
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96500282
78FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96153622
79KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94818500
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.94784644
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94305826
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92270487
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91938374
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91503571
85EST1_17652178_ChIP-ChIP_JURKAT_Human0.90783935
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90430843
87MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89028319
88* SOX2_20726797_ChIP-Seq_SW620_Human0.88536335
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87554786
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.87034316
91MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86518547
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86481389
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86381315
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.85776853
95MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85721791
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.85328936
97* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85145628
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84222313
99AR_21909140_ChIP-Seq_LNCAP_Human0.83560010
100PHF8_20622853_ChIP-Seq_HELA_Human0.82895498
101* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82390974
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80659575
103IRF8_22096565_ChIP-ChIP_GC-B_Human0.79029589
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78825354
105* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77842695
106* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77842695
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77758811
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77357392
109* GATA6_25053715_ChIP-Seq_YYC3_Human0.76937470
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72962886
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.72860601
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72761265
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.72266279
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68492474
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65951348
116LXR_22292898_ChIP-Seq_THP-1_Human0.65788742
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64857828
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63467886
119RACK7_27058665_Chip-Seq_MCF-7_Human0.60968364
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.60581976
121PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.59198114
122CEBPB_22108803_ChIP-Seq_LS180_Human0.58793482
123AR_20517297_ChIP-Seq_VCAP_Human0.58771264
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.57899288
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57703275
126EGR1_19032775_ChIP-ChIP_M12_Human0.57306405
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.56847797
128ATF3_27146783_Chip-Seq_COLON_Human0.56636987
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.55350154
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55177747
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.55115444
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.53855866
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.53855866
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.52864367
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.52581130
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.52267055
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.52184282
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.51804628
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.51715029
140P63_26484246_Chip-Seq_KERATINOCYTES_Human0.50611367
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.49987410
142KAP1_22055183_ChIP-Seq_ESCs_Mouse0.48306060
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46575960
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45788920
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.45406085
146GATA2_19941826_ChIP-Seq_K562_Human0.45390960
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45352325
148CJUN_26792858_Chip-Seq_BT549_Human0.45256179
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.44695087
150CSB_26484114_Chip-Seq_FIBROBLAST_Human0.44006423
151* CBP_21632823_ChIP-Seq_H3396_Human0.43040899
152SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42997194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.76145302
2MP0005360_urolithiasis7.35614812
3MP0005085_abnormal_gallbladder_physiolo5.93656186
4MP0005365_abnormal_bile_salt5.55507646
5MP0004147_increased_porphyrin_level5.13177657
6MP0008875_abnormal_xenobiotic_pharmacok4.93912698
7MP0003806_abnormal_nucleotide_metabolis4.19860307
8MP0003252_abnormal_bile_duct3.64445599
9MP0010329_abnormal_lipoprotein_level3.33213782
10MP0004264_abnormal_extraembryonic_tissu3.24839821
11MP0010352_gastrointestinal_tract_polyps3.20068159
12MP0009840_abnormal_foam_cell3.12966874
13MP0005083_abnormal_biliary_tract2.83366406
14MP0003183_abnormal_peptide_metabolism2.73629760
15MP0001666_abnormal_nutrient_absorption2.72673465
16* MP0005332_abnormal_amino_acid2.69119134
17MP0003718_maternal_effect2.68370659
18MP0003195_calcinosis2.48508264
19MP0003941_abnormal_skin_development2.26813760
20MP0004019_abnormal_vitamin_homeostasis2.12191260
21MP0003191_abnormal_cellular_cholesterol2.10863405
22MP0003705_abnormal_hypodermis_morpholog1.99765618
23MP0000609_abnormal_liver_physiology1.98063984
24MP0002138_abnormal_hepatobiliary_system1.94650512
25MP0002118_abnormal_lipid_homeostasis1.93074207
26MP0005319_abnormal_enzyme/_coenzyme1.79897729
27MP0004957_abnormal_blastocyst_morpholog1.75807383
28MP0009780_abnormal_chondrocyte_physiolo1.72594177
29MP0003693_abnormal_embryo_hatching1.65815368
30MP0001188_hyperpigmentation1.64793087
31MP0003186_abnormal_redox_activity1.57228118
32MP0001764_abnormal_homeostasis1.54138524
33MP0005584_abnormal_enzyme/coenzyme_acti1.53579901
34MP0005409_darkened_coat_color1.52144735
35MP0003868_abnormal_feces_composition1.51301918
36MP0000678_abnormal_parathyroid_gland1.47355891
37MP0004272_abnormal_basement_membrane1.45585435
38MP0001664_abnormal_digestion1.36691758
39MP0003011_delayed_dark_adaptation1.34681055
40* MP0009643_abnormal_urine_homeostasis1.34634801
41MP0003656_abnormal_erythrocyte_physiolo1.30089288
42MP0003950_abnormal_plasma_membrane1.26676582
43MP0009697_abnormal_copulation1.26094479
44MP0004270_analgesia1.25555418
45MP0000462_abnormal_digestive_system1.25172993
46MP0001881_abnormal_mammary_gland1.22530218
47MP0005501_abnormal_skin_physiology1.21108337
48MP0002254_reproductive_system_inflammat1.19494577
49MP0005451_abnormal_body_composition1.14504881
50MP0008438_abnormal_cutaneous_collagen1.12654253
51MP0000537_abnormal_urethra_morphology1.12158847
52MP0000598_abnormal_liver_morphology1.11607123
53MP0005408_hypopigmentation1.09170842
54MP0009384_cardiac_valve_regurgitation1.08887829
55MP0009764_decreased_sensitivity_to1.07485848
56MP0010155_abnormal_intestine_physiology1.03472237
57MP0000490_abnormal_crypts_of1.01401080
58MP0005636_abnormal_mineral_homeostasis0.97578199
59MP0005647_abnormal_sex_gland0.97295616
60MP0000477_abnormal_intestine_morphology0.95819514
61MP0010368_abnormal_lymphatic_system0.95709008
62MP0002098_abnormal_vibrissa_morphology0.94408240
63MP0008932_abnormal_embryonic_tissue0.93206426
64MP0000604_amyloidosis0.93179142
65MP0006036_abnormal_mitochondrial_physio0.93153389
66MP0000516_abnormal_urinary_system0.91895105
67MP0005367_renal/urinary_system_phenotyp0.91895105
68MP0009763_increased_sensitivity_to0.91877046
69MP0004130_abnormal_muscle_cell0.90255070
70MP0010307_abnormal_tumor_latency0.87380865
71MP0008469_abnormal_protein_level0.81992608
72MP0010678_abnormal_skin_adnexa0.81781421
73MP0005376_homeostasis/metabolism_phenot0.80862828
74MP0005257_abnormal_intraocular_pressure0.80441276
75MP0001765_abnormal_ion_homeostasis0.79205225
76* MP0009642_abnormal_blood_homeostasis0.79059685
77MP0001756_abnormal_urination0.78308868
78MP0005084_abnormal_gallbladder_morpholo0.77609404
79MP0004782_abnormal_surfactant_physiolog0.74064538
80MP0008260_abnormal_autophagy0.73954290
81MP0005670_abnormal_white_adipose0.73487956
82MP0000427_abnormal_hair_cycle0.72414349
83MP0001730_embryonic_growth_arrest0.72235956
84MP0005275_abnormal_skin_tensile0.72209790
85MP0009053_abnormal_anal_canal0.71169484
86MP0000762_abnormal_tongue_morphology0.70435443
87MP0002896_abnormal_bone_mineralization0.69332525
88MP0003566_abnormal_cell_adhesion0.69121366
89MP0002837_dystrophic_cardiac_calcinosis0.69112603
90MP0001216_abnormal_epidermal_layer0.68728587
91MP0002971_abnormal_brown_adipose0.67772736
92MP0005220_abnormal_exocrine_pancreas0.67276477
93MP0003111_abnormal_nucleus_morphology0.66692923
94MP0000627_abnormal_mammary_gland0.65786876
95MP0000467_abnormal_esophagus_morphology0.65667065
96MP0005266_abnormal_metabolism0.63261042
97MP0009765_abnormal_xenobiotic_induced0.63254767
98MP0003300_gastrointestinal_ulcer0.63097552
99MP0002078_abnormal_glucose_homeostasis0.63042462
100MP0003315_abnormal_perineum_morphology0.61863334
101MP0002136_abnormal_kidney_physiology0.61271829
102MP0003724_increased_susceptibility_to0.59748220
103MP0010234_abnormal_vibrissa_follicle0.59205646
104MP0003690_abnormal_glial_cell0.59193995
105MP0002876_abnormal_thyroid_physiology0.58743705
106MP0002060_abnormal_skin_morphology0.58052963
107MP0001501_abnormal_sleep_pattern0.57713917
108MP0005666_abnormal_adipose_tissue0.57683886
109MP0002295_abnormal_pulmonary_circulatio0.57442259
110MP0000015_abnormal_ear_pigmentation0.57173378
111MP0003786_premature_aging0.56002548
112MP0005334_abnormal_fat_pad0.54649763
113MP0008058_abnormal_DNA_repair0.54007844
114MP0003329_amyloid_beta_deposits0.53737694
115MP0010771_integument_phenotype0.53729933
116MP0005174_abnormal_tail_pigmentation0.53649564
117MP0001243_abnormal_dermal_layer0.52681382
118MP0005166_decreased_susceptibility_to0.52538263
119MP0003638_abnormal_response/metabolism_0.51456909
120MP0000377_abnormal_hair_follicle0.51106064
121MP0005023_abnormal_wound_healing0.50748498
122MP0003279_aneurysm0.49954419
123MP0008004_abnormal_stomach_pH0.49686859
124MP0006054_spinal_hemorrhage0.49672431
125MP0004215_abnormal_myocardial_fiber0.48467618
126MP0006035_abnormal_mitochondrial_morpho0.48364839
127MP0009379_abnormal_foot_pigmentation0.47545670
128MP0005535_abnormal_body_temperature0.47394849
129MP0001191_abnormal_skin_condition0.47328371
130MP0002938_white_spotting0.46985806
131MP0001661_extended_life_span0.46495980
132MP0001853_heart_inflammation0.46458982
133MP0001485_abnormal_pinna_reflex0.46024698
134MP0005448_abnormal_energy_balance0.45672828
135MP0008007_abnormal_cellular_replicative0.45556942
136MP0003075_altered_response_to0.45058491
137MP0005164_abnormal_response_to0.44692765
138MP0002796_impaired_skin_barrier0.44124255
139MP0001958_emphysema0.43543802
140MP0005058_abnormal_lysosome_morphology0.42797346
141MP0002132_abnormal_respiratory_system0.42661215
142MP0000639_abnormal_adrenal_gland0.42145134
143MP0000230_abnormal_systemic_arterial0.42031030
144MP0008872_abnormal_physiological_respon0.41455285
145MP0004043_abnormal_pH_regulation0.41403496
146MP0004883_abnormal_blood_vessel0.41235480
147MP0005395_other_phenotype0.40874511
148MP0000249_abnormal_blood_vessel0.40423746
149MP0008873_increased_physiological_sensi0.39463343
150MP0001873_stomach_inflammation0.37833279
151MP0005595_abnormal_vascular_smooth0.36301782
152MP0005165_increased_susceptibility_to0.35936662
153MP0005330_cardiomyopathy0.35523964
154MP0000538_abnormal_urinary_bladder0.35401145

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.63315193
2Intrahepatic cholestasis (HP:0001406)6.58482237
3Deep venous thrombosis (HP:0002625)6.49268537
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.25787869
5Hypobetalipoproteinemia (HP:0003563)5.89357347
6Xanthomatosis (HP:0000991)5.89296399
7Prolonged partial thromboplastin time (HP:0003645)5.38209622
8Abnormality of the vitamin B12 metabolism (HP:0004341)4.89102233
9Hyperlipoproteinemia (HP:0010980)4.85708058
10Hyperammonemia (HP:0001987)4.85364064
11Abnormality of vitamin B metabolism (HP:0004340)4.67697384
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.62298774
13Complement deficiency (HP:0004431)4.57674022
14Hypolipoproteinemia (HP:0010981)4.48558485
15Ketosis (HP:0001946)4.35067479
16Epidermoid cyst (HP:0200040)4.13843451
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.13280659
18Hyperglycinuria (HP:0003108)4.11683124
19Hyperglycinemia (HP:0002154)4.06146647
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04456074
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.04413342
22Confusion (HP:0001289)4.04100201
23Abnormality of serine family amino acid metabolism (HP:0010894)4.00100700
24Abnormality of glycine metabolism (HP:0010895)4.00100700
25Abnormality of methionine metabolism (HP:0010901)3.92605475
26Hypoalphalipoproteinemia (HP:0003233)3.92369266
27Abnormality of the common coagulation pathway (HP:0010990)3.91385092
28Hypoglycemic coma (HP:0001325)3.79861038
29Fat malabsorption (HP:0002630)3.76071277
30Joint hemorrhage (HP:0005261)3.75493674
31Abnormality of fatty-acid metabolism (HP:0004359)3.68275142
32Megaloblastic anemia (HP:0001889)3.65901754
33Ketoacidosis (HP:0001993)3.54270847
34Abnormality of pyrimidine metabolism (HP:0004353)3.46534264
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45405152
36Abnormality of the intrinsic pathway (HP:0010989)3.45363797
37Abnormality of complement system (HP:0005339)3.38810133
38Patchy hypopigmentation of hair (HP:0011365)3.32874728
39Chronic diarrhea (HP:0002028)3.30098490
40Hypercholesterolemia (HP:0003124)3.27640001
41Conjugated hyperbilirubinemia (HP:0002908)3.18596689
42White forelock (HP:0002211)3.18256295
43Hyperbilirubinemia (HP:0002904)3.15329454
44Widely patent fontanelles and sutures (HP:0004492)3.15108570
45Abnormality of nucleobase metabolism (HP:0010932)3.07589477
46Delayed CNS myelination (HP:0002188)3.01218857
47Abnormality of serum amino acid levels (HP:0003112)2.99003313
48Hepatocellular carcinoma (HP:0001402)2.91481345
49Abnormality of purine metabolism (HP:0004352)2.88117084
50Metabolic acidosis (HP:0001942)2.84743695
51Pili torti (HP:0003777)2.84454295
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82360291
53Dicarboxylic aciduria (HP:0003215)2.82360291
54Lethargy (HP:0001254)2.79782518
55Abnormality of glycolysis (HP:0004366)2.78360448
56Increased serum pyruvate (HP:0003542)2.77904179
57Gout (HP:0001997)2.75612375
58Steatorrhea (HP:0002570)2.72851356
59Symptomatic seizures (HP:0011145)2.72510697
60Myocardial infarction (HP:0001658)2.71257282
61Skin nodule (HP:0200036)2.70255335
62Cerebral edema (HP:0002181)2.68568770
63Spastic diplegia (HP:0001264)2.65063605
64Wide cranial sutures (HP:0010537)2.56349900
65Nephrolithiasis (HP:0000787)2.56077349
66Spontaneous abortion (HP:0005268)2.44804234
67Vascular calcification (HP:0004934)2.44090510
68Right ventricular cardiomyopathy (HP:0011663)2.43364364
69Malnutrition (HP:0004395)2.43023859
70Hydroxyprolinuria (HP:0003080)2.40979542
71Abnormality of proline metabolism (HP:0010907)2.40979542
72Acanthocytosis (HP:0001927)2.39314327
73Late onset (HP:0003584)2.38353635
74Hyperphosphaturia (HP:0003109)2.37046494
75Cholelithiasis (HP:0001081)2.36791624
76Abnormal gallbladder morphology (HP:0012437)2.36780647
77Abnormal cartilage morphology (HP:0002763)2.36394176
78Systemic lupus erythematosus (HP:0002725)2.36204928
79Cardiovascular calcification (HP:0011915)2.32193465
80Vomiting (HP:0002013)2.27811540
81Mitral stenosis (HP:0001718)2.26834577
82Esophageal varix (HP:0002040)2.26702476
83Neonatal onset (HP:0003623)2.24276770
84Abnormal glucose tolerance (HP:0001952)2.23091220
85Generalized aminoaciduria (HP:0002909)2.22034032
86Hyperactive renin-angiotensin system (HP:0000841)2.19613144
87Abnormal urine phosphate concentration (HP:0012599)2.17958954
88Irritability (HP:0000737)2.16100992
89Alopecia of scalp (HP:0002293)2.15398298
90Abnormal gallbladder physiology (HP:0012438)2.14842606
91Cholecystitis (HP:0001082)2.14842606
92Abnormal hair laboratory examination (HP:0003328)2.12045041
93Pigmentary retinal degeneration (HP:0001146)2.10089360
94Amyloidosis (HP:0011034)2.09823872
95Ileus (HP:0002595)2.07394081
96Sensorimotor neuropathy (HP:0007141)2.07262176
97Proximal tubulopathy (HP:0000114)2.06600819
98Neoplasm of the small intestine (HP:0100833)2.06574561
99Neoplasm of the rectum (HP:0100743)2.06508697
100Abnormal biliary tract morphology (HP:0012440)2.05433385
101Increased purine levels (HP:0004368)2.04613056
102Hyperuricemia (HP:0002149)2.04613056
103Opisthotonus (HP:0002179)2.04237639
104Pancreatitis (HP:0001733)2.03742504
105Glomerulonephritis (HP:0000099)2.01662747
106Palpitations (HP:0001962)2.01275112
107Hypotension (HP:0002615)1.99605449
108Biliary tract neoplasm (HP:0100574)1.99031258
109Hyperparathyroidism (HP:0000843)1.97829033
110Premature rupture of membranes (HP:0001788)1.96836316
111Thin bony cortex (HP:0002753)1.96602238
112Hypoglycemic seizures (HP:0002173)1.96595641
113Alkalosis (HP:0001948)1.95789256
114Nausea (HP:0002018)1.94701031
115Abnormality of the gallbladder (HP:0005264)1.93173611
116Brushfield spots (HP:0001088)1.92371697
117Abnormality of small intestinal villus morphology (HP:0011472)1.92037777
118Villous atrophy (HP:0011473)1.92037777
119Myoglobinuria (HP:0002913)1.91428035
120Abdominal distention (HP:0003270)1.90448454
121Glycosuria (HP:0003076)1.88981443
122Abnormality of urine glucose concentration (HP:0011016)1.88981443
123Renal tubular acidosis (HP:0001947)1.86367564
124Renal tubular dysfunction (HP:0000124)1.84828415
125Hypochromic microcytic anemia (HP:0004840)1.83860201
126Enlarged kidneys (HP:0000105)1.83216183
127Thrombophlebitis (HP:0004418)1.83078572
128Abnormality of transition element cation homeostasis (HP:0011030)1.82810627
129Abnormality of the costochondral junction (HP:0000919)1.81614739
130Abnormal umbilical cord blood vessels (HP:0011403)1.81398960
131Single umbilical artery (HP:0001195)1.81398960
132Abnormality of the fetal cardiovascular system (HP:0010948)1.81398960
133Respiratory distress (HP:0002098)1.81134115
134Abnormality of vitamin metabolism (HP:0100508)1.80972758
135Abnormality of magnesium homeostasis (HP:0004921)1.79971337
136Abnormality of iron homeostasis (HP:0011031)1.79084813
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.78119710
138Osteolytic defects of the hand bones (HP:0009699)1.78119710
139Poikilocytosis (HP:0004447)1.77549701
140Back pain (HP:0003418)1.77177160
141Abnormal enzyme/coenzyme activity (HP:0012379)1.75998392
142Congenital sensorineural hearing impairment (HP:0008527)1.75309698
143Elevated hepatic transaminases (HP:0002910)1.72369381
144Potter facies (HP:0002009)1.71704525
145Facial shape deformation (HP:0011334)1.71704525
146Hepatic necrosis (HP:0002605)1.71072920
147Hypophosphatemia (HP:0002148)1.70505995
148Hyperphosphatemia (HP:0002905)1.69507415
149Hyperinsulinemic hypoglycemia (HP:0000825)1.68395238
150Methylmalonic aciduria (HP:0012120)1.67096470
151Cerebral palsy (HP:0100021)1.67026649
152Chondrocalcinosis (HP:0000934)1.64145049
153Abnormality of the umbilical cord (HP:0010881)1.64073461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.09300308
2MST44.89503466
3ACVR1B4.64160690
4ERN14.03402024
5SIK13.78339229
6FGFR43.42636276
7LMTK23.26670623
8TRIB33.24321396
9PKN23.09966297
10MAP3K122.89930069
11MST1R2.88460125
12TSSK62.71268691
13EPHA22.60041362
14EIF2AK12.58436766
15BUB12.30783092
16EIF2AK32.30613496
17TTK2.10737985
18TRIM282.06325729
19FRK1.98136071
20BRSK21.95667281
21FLT31.94913802
22LATS11.84769047
23ERBB41.82262204
24WEE11.76629090
25PTK61.71825223
26TAOK31.61186619
27NEK91.61091282
28MAP3K31.60600058
29PIK3CG1.57270887
30STK391.51013169
31PDK41.50917539
32PDK31.50917539
33MYLK1.47649084
34ERBB31.45987411
35STK241.45820116
36PAK41.44298669
37SRPK11.43038003
38MAPK111.42499636
39OXSR11.37563924
40TTN1.36676753
41TYK21.31991501
42PLK31.31751947
43MET1.31497025
44INSRR1.27734758
45BRSK11.24402595
46FGFR21.23227361
47STK38L1.22363276
48MAP2K61.19745215
49MAP2K31.19592953
50ABL21.18974321
51RIPK11.15946813
52TNIK1.14842685
53KDR1.13585302
54LRRK21.10974896
55NEK11.10178131
56MAP2K41.09381566
57PBK1.07806851
58TBK11.06657018
59TESK11.06427628
60EPHA41.05512747
61BCR1.04422348
62NEK61.03288966
63BMPR20.99241120
64CASK0.98584398
65ERBB20.97379786
66MKNK20.97119855
67STK160.94212248
68EPHA30.94127980
69PDK20.93448426
70DAPK20.92232359
71AKT30.91548018
72EPHB10.91295847
73GRK60.91039550
74TGFBR20.90799775
75MAP3K110.89161964
76MAP3K100.88688683
77MAP2K20.87331368
78PRKAA20.83984091
79MAP3K70.83561426
80PRKG20.82127313
81JAK20.81332902
82PIK3CA0.80437656
83PLK10.78546456
84MAP2K10.75260020
85CDK60.74408877
86TIE10.74160792
87JAK10.69429980
88PDGFRA0.67874628
89MAPK40.67773890
90PINK10.67266673
91PTK20.67195342
92EPHB20.66198878
93PRKCI0.66080482
94KSR20.63880236
95DDR20.62786982
96CAMK2G0.60087597
97FER0.59900735
98LIMK10.59400321
99GSK3A0.59074479
100LATS20.58867038
101MAPK120.57525303
102NME10.55696148
103PLK40.55563973
104ILK0.54577341
105SIK30.54342416
106BRAF0.54148486
107TGFBR10.53676159
108TAOK20.53433181
109IRAK30.52404393
110CAMK2D0.51648721
111MKNK10.51423844
112PRKACG0.50529098
113STK40.49775253
114PHKG20.48967792
115PHKG10.48967792
116BMX0.48262844
117PRKCZ0.46627388
118MAPK150.46429006
119CDK190.44182445
120PRKAA10.44139580
121PAK30.43078364
122NUAK10.42803469
123FGFR10.41836270
124NME20.41046834
125DYRK1B0.40288083
126OBSCN0.39939674
127DAPK10.39847028
128STK30.39679624
129TESK20.39521455
130RET0.38442815
131KSR10.37423701
132FGFR30.37121585
133AKT20.35831180
134AURKB0.35545050
135GRK10.35528686
136PDPK10.34382716
137CLK10.34124469
138EIF2AK20.33772479
139RAF10.32704724
140SCYL20.32634927
141MINK10.32204653
142PAK10.31917367
143PAK20.31557187
144IGF1R0.31450803
145MAP3K20.31380288
146PLK20.31370101
147CSF1R0.31257880
148CDK40.30640182
149MAP3K50.29518513
150MAP3K80.29515237
151ROCK10.29447584
152PRKCQ0.29078544
153SGK30.28876437
154PRKCA0.28869064
155MAP3K140.27737746
156ARAF0.27381016
157STK100.27295393
158PAK60.26195596
159PIM20.25869764
160PRKCE0.25838966
161ALK0.24907199
162ROCK20.23785854
163GRK50.22807922

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.98860997
2Nitrogen metabolism_Homo sapiens_hsa009103.72789640
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47948565
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18965089
5Arginine biosynthesis_Homo sapiens_hsa002202.97706384
6Fatty acid degradation_Homo sapiens_hsa000712.78524245
7Tryptophan metabolism_Homo sapiens_hsa003802.70460561
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58823754
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57931077
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57071066
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40389341
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35983012
13Complement and coagulation cascades_Homo sapiens_hsa046102.29330985
14Propanoate metabolism_Homo sapiens_hsa006402.17086998
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09718669
16Butanoate metabolism_Homo sapiens_hsa006502.05127147
17Peroxisome_Homo sapiens_hsa041461.99459162
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94475939
19Fatty acid metabolism_Homo sapiens_hsa012121.92824272
20Histidine metabolism_Homo sapiens_hsa003401.92588268
21Caffeine metabolism_Homo sapiens_hsa002321.91028832
22Chemical carcinogenesis_Homo sapiens_hsa052041.90221196
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90189705
24PPAR signaling pathway_Homo sapiens_hsa033201.88745093
25Proteasome_Homo sapiens_hsa030501.79734839
26beta-Alanine metabolism_Homo sapiens_hsa004101.77334755
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.69765695
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67191374
29Pyruvate metabolism_Homo sapiens_hsa006201.64295269
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59961025
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.58815780
32Retinol metabolism_Homo sapiens_hsa008301.58707215
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51294424
34Selenocompound metabolism_Homo sapiens_hsa004501.51033906
35Sulfur metabolism_Homo sapiens_hsa009201.50469889
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46736940
37Phenylalanine metabolism_Homo sapiens_hsa003601.45629542
38Bile secretion_Homo sapiens_hsa049761.42760784
39Carbon metabolism_Homo sapiens_hsa012001.41376859
40Biosynthesis of amino acids_Homo sapiens_hsa012301.39833645
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.36681383
42Starch and sucrose metabolism_Homo sapiens_hsa005001.34909478
43Tyrosine metabolism_Homo sapiens_hsa003501.34184668
44Staphylococcus aureus infection_Homo sapiens_hsa051501.32610855
45Fatty acid elongation_Homo sapiens_hsa000621.31971691
46Folate biosynthesis_Homo sapiens_hsa007901.23833574
47Fat digestion and absorption_Homo sapiens_hsa049751.23745784
48Sphingolipid metabolism_Homo sapiens_hsa006001.23574348
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21396622
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19397929
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18143125
52* Arginine and proline metabolism_Homo sapiens_hsa003301.04484101
53Steroid biosynthesis_Homo sapiens_hsa001001.04296970
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03793482
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.00096712
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97605991
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96090363
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94818546
59ABC transporters_Homo sapiens_hsa020100.94676883
60Glutathione metabolism_Homo sapiens_hsa004800.91664534
61Vitamin digestion and absorption_Homo sapiens_hsa049770.91176333
62Sulfur relay system_Homo sapiens_hsa041220.88633846
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85334161
64Pentose phosphate pathway_Homo sapiens_hsa000300.77840692
65Lysine degradation_Homo sapiens_hsa003100.76600429
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75696929
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.73100160
68Protein export_Homo sapiens_hsa030600.71644568
69One carbon pool by folate_Homo sapiens_hsa006700.71572356
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70082953
71Glycerolipid metabolism_Homo sapiens_hsa005610.69086960
72Fatty acid biosynthesis_Homo sapiens_hsa000610.63308293
73N-Glycan biosynthesis_Homo sapiens_hsa005100.63239300
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60515608
75Ether lipid metabolism_Homo sapiens_hsa005650.56227899
76* Metabolic pathways_Homo sapiens_hsa011000.49683145
77Vitamin B6 metabolism_Homo sapiens_hsa007500.49189495
78Galactose metabolism_Homo sapiens_hsa000520.46122353
79Vibrio cholerae infection_Homo sapiens_hsa051100.45121354
80Fructose and mannose metabolism_Homo sapiens_hsa000510.45008876
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42569967
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39659593
83Mismatch repair_Homo sapiens_hsa034300.31452490
84Tight junction_Homo sapiens_hsa045300.31179560
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.27262249
86Pancreatic secretion_Homo sapiens_hsa049720.26988430
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25635233
88Insulin resistance_Homo sapiens_hsa049310.24938943
89Non-homologous end-joining_Homo sapiens_hsa034500.22358186
90Purine metabolism_Homo sapiens_hsa002300.21842679
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20490011
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19902333
93Prion diseases_Homo sapiens_hsa050200.18121974
94Linoleic acid metabolism_Homo sapiens_hsa005910.14918608
95Pyrimidine metabolism_Homo sapiens_hsa002400.14614101
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14526443
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13844159
98Huntingtons disease_Homo sapiens_hsa050160.12486891
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11957717
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11130421
101DNA replication_Homo sapiens_hsa030300.07950464
102TGF-beta signaling pathway_Homo sapiens_hsa043500.06715444
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06662369
104Renin-angiotensin system_Homo sapiens_hsa046140.05147287
105Glucagon signaling pathway_Homo sapiens_hsa049220.04229654
106Protein digestion and absorption_Homo sapiens_hsa049740.03727649
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.03426977
108AMPK signaling pathway_Homo sapiens_hsa041520.03002831
109Legionellosis_Homo sapiens_hsa05134-0.1998075
110Pertussis_Homo sapiens_hsa05133-0.1692123
111Alzheimers disease_Homo sapiens_hsa05010-0.1674108
112Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1579049
113ECM-receptor interaction_Homo sapiens_hsa04512-0.1340043
114Amoebiasis_Homo sapiens_hsa05146-0.1295211
115Hepatitis C_Homo sapiens_hsa05160-0.1281523
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1215205
117Insulin signaling pathway_Homo sapiens_hsa04910-0.1101213
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1099327
119Bladder cancer_Homo sapiens_hsa05219-0.1097395
120Parkinsons disease_Homo sapiens_hsa05012-0.0950844
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0935554
122Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0722914
123Oxidative phosphorylation_Homo sapiens_hsa00190-0.0630532
124Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0535492
125Mineral absorption_Homo sapiens_hsa04978-0.0372010

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