OAZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.82922578
2DNA deamination (GO:0045006)5.61632315
3neutrophil activation involved in immune response (GO:0002283)5.38687068
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78274545
5proteasome assembly (GO:0043248)4.71733454
6viral transcription (GO:0019083)4.67912317
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.65085094
8negative regulation of cell killing (GO:0031342)4.65085094
9positive regulation of gamma-delta T cell activation (GO:0046645)4.62384637
10DNA strand elongation involved in DNA replication (GO:0006271)4.54180223
11telomere maintenance via semi-conservative replication (GO:0032201)4.51783913
12translational termination (GO:0006415)4.51584910
13maturation of SSU-rRNA (GO:0030490)4.47637711
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.42015665
15ribosomal small subunit biogenesis (GO:0042274)4.38641502
16cotranslational protein targeting to membrane (GO:0006613)4.36289239
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.33107801
18DNA strand elongation (GO:0022616)4.32468221
19response to peptidoglycan (GO:0032494)4.32396697
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.31893957
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.31893957
22modulation by symbiont of host immune response (GO:0052553)4.31893957
23positive regulation by symbiont of host defense response (GO:0052509)4.31893957
24modulation by symbiont of host defense response (GO:0052031)4.31893957
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.31893957
26antigen processing and presentation of endogenous antigen (GO:0019883)4.30425637
27protein targeting to ER (GO:0045047)4.30010423
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.21677887
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.20926656
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17719264
31translational elongation (GO:0006414)4.16569719
32protein localization to endoplasmic reticulum (GO:0070972)4.12093027
33establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06333846
34detection of other organism (GO:0098543)3.98795952
35immunoglobulin mediated immune response (GO:0016064)3.95847476
36telomere maintenance via recombination (GO:0000722)3.95450067
37ATP synthesis coupled proton transport (GO:0015986)3.95369970
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95369970
39detection of bacterium (GO:0016045)3.95104778
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.90330156
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.87169771
42negative regulation of ligase activity (GO:0051352)3.85781228
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.85781228
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.85414600
45negative regulation of interleukin-12 production (GO:0032695)3.84339448
46translational initiation (GO:0006413)3.78455871
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76264807
48formation of translation preinitiation complex (GO:0001731)3.74753268
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.72246827
50protein deneddylation (GO:0000338)3.70740794
51translation (GO:0006412)3.69456051
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.69347361
53DNA replication initiation (GO:0006270)3.69127992
54ribosomal large subunit biogenesis (GO:0042273)3.68791053
55DNA replication checkpoint (GO:0000076)3.67727540
56viral life cycle (GO:0019058)3.67377591
57respiratory burst (GO:0045730)3.66973757
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66762899
59regulation of mast cell degranulation (GO:0043304)3.63766649
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.60619856
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.60619856
62negative regulation of erythrocyte differentiation (GO:0045647)3.60417169
63cellular protein complex disassembly (GO:0043624)3.59503715
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59019965
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59019965
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59019965
67* regulation of cellular amino acid metabolic process (GO:0006521)3.58038899
68cullin deneddylation (GO:0010388)3.57979414
69macrophage activation involved in immune response (GO:0002281)3.52448448
70neutrophil activation (GO:0042119)3.51335613
71mitotic recombination (GO:0006312)3.50069840
727-methylguanosine mRNA capping (GO:0006370)3.49871892
73granulocyte activation (GO:0036230)3.49319391
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.48816756
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48775109
76termination of RNA polymerase III transcription (GO:0006386)3.48744029
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.48744029
78Arp2/3 complex-mediated actin nucleation (GO:0034314)3.46552021
797-methylguanosine RNA capping (GO:0009452)3.46234995
80RNA capping (GO:0036260)3.46234995
81regulation of B cell receptor signaling pathway (GO:0050855)3.45517540
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45201007
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.45201007
84mitochondrial respiratory chain complex I assembly (GO:0032981)3.41238139
85NADH dehydrogenase complex assembly (GO:0010257)3.41238139
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41238139
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.40662625
88transcription-coupled nucleotide-excision repair (GO:0006283)3.38587851
89respiratory chain complex IV assembly (GO:0008535)3.38329222
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.38109286
91nucleobase biosynthetic process (GO:0046112)3.38104475
92ribonucleoprotein complex biogenesis (GO:0022613)3.37942846
93telomere maintenance via telomere lengthening (GO:0010833)3.37033988
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35770099
95metallo-sulfur cluster assembly (GO:0031163)3.35219697
96iron-sulfur cluster assembly (GO:0016226)3.35219697
97CENP-A containing nucleosome assembly (GO:0034080)3.33926224
98protein complex biogenesis (GO:0070271)3.31517681
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30888345
100purine nucleobase biosynthetic process (GO:0009113)3.30389232
101leukocyte aggregation (GO:0070486)3.28905019
102positive regulation of ligase activity (GO:0051351)3.27350695
103regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27344003
104positive regulation of B cell differentiation (GO:0045579)3.27294674
105regulation of leukocyte degranulation (GO:0043300)3.27108246
106chaperone-mediated protein transport (GO:0072321)3.26217303
107oxidative phosphorylation (GO:0006119)3.25836014
108pseudouridine synthesis (GO:0001522)3.24250842
109detection of external biotic stimulus (GO:0098581)3.22113208
110regulation of mast cell activation involved in immune response (GO:0033006)3.21243967
111myeloid cell activation involved in immune response (GO:0002275)3.20877103
112positive regulation of mast cell activation (GO:0033005)3.18154192
113cellular component biogenesis (GO:0044085)3.17161510
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16539332
115B cell mediated immunity (GO:0019724)3.16286324
116guanosine-containing compound biosynthetic process (GO:1901070)3.15554291
117mitochondrial respiratory chain complex assembly (GO:0033108)3.14886762
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14666814
119chromatin remodeling at centromere (GO:0031055)3.13515053
120protein complex disassembly (GO:0043241)3.13233554
121peptidyl-histidine modification (GO:0018202)3.11341690
122regulation of mitochondrial translation (GO:0070129)3.09308879
123spliceosomal snRNP assembly (GO:0000387)3.06507055
124rRNA processing (GO:0006364)3.05249507
125cell cycle G1/S phase transition (GO:0044843)3.03952213
126G1/S transition of mitotic cell cycle (GO:0000082)3.03952213
127lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03919408
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.03464960
129response to host immune response (GO:0052572)3.03464960
130cellular extravasation (GO:0045123)3.02425287
131macromolecular complex disassembly (GO:0032984)3.00937538
132regulation of gamma-delta T cell activation (GO:0046643)3.00856366
133antigen processing and presentation via MHC class Ib (GO:0002475)3.00604765
134NIK/NF-kappaB signaling (GO:0038061)3.00517067
135regulation of ubiquitin-protein transferase activity (GO:0051438)3.00240954
136rRNA modification (GO:0000154)2.98031551
137protein targeting to mitochondrion (GO:0006626)2.97523149
138viral mRNA export from host cell nucleus (GO:0046784)2.96533870
139cytochrome complex assembly (GO:0017004)2.95837126
140nucleobase-containing small molecule interconversion (GO:0015949)2.95433051
141deoxyribonucleotide biosynthetic process (GO:0009263)2.95054718
142regulation of ligase activity (GO:0051340)2.94768307
143deoxyribose phosphate biosynthetic process (GO:0046385)2.93625641
1442-deoxyribonucleotide biosynthetic process (GO:0009265)2.93625641
145regulation of interferon-beta biosynthetic process (GO:0045357)2.92928130
146leukocyte degranulation (GO:0043299)2.90130686
147regulation of superoxide anion generation (GO:0032928)2.88192123
148negative regulation of leukocyte mediated immunity (GO:0002704)2.83745426
149type I interferon signaling pathway (GO:0060337)2.82166567
150cellular response to type I interferon (GO:0071357)2.82166567
151positive regulation of mast cell activation involved in immune response (GO:0033008)2.80773076
152positive regulation of mast cell degranulation (GO:0043306)2.80773076
153B cell receptor signaling pathway (GO:0050853)2.80429100
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79619515
155response to host (GO:0075136)2.79619515
156response to host defenses (GO:0052200)2.79619515
157pinocytosis (GO:0006907)2.79332862
158interferon-gamma-mediated signaling pathway (GO:0060333)2.79191482
159regulation of mast cell activation (GO:0033003)2.78754871
160negative regulation of lymphocyte mediated immunity (GO:0002707)2.77126919
161response to type I interferon (GO:0034340)2.76315551
162regulation of defense response to virus by virus (GO:0050690)2.75551996
163detection of biotic stimulus (GO:0009595)2.75461624
164amino sugar catabolic process (GO:0046348)2.73719781
165regulation of regulated secretory pathway (GO:1903305)2.72682534
166positive thymic T cell selection (GO:0045059)2.72669015
167detection of molecule of bacterial origin (GO:0032490)2.69312923
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69137260
169leukocyte migration involved in inflammatory response (GO:0002523)2.66618633
170negative regulation of myeloid cell apoptotic process (GO:0033033)2.64460607
171regulation of T cell tolerance induction (GO:0002664)2.64412992
172negative regulation of phagocytosis (GO:0050765)2.63383451
173regulation of B cell differentiation (GO:0045577)2.62328078
174microglial cell activation (GO:0001774)2.62262277
175response to muramyl dipeptide (GO:0032495)2.61911838
176macrophage activation (GO:0042116)2.61376607
177regulation of gamma-delta T cell differentiation (GO:0045586)2.61329232
178actin nucleation (GO:0045010)2.61006558
179positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59698011
180T cell migration (GO:0072678)2.59687476
181negative regulation of innate immune response (GO:0045824)2.58443566
182positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58020756
183positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57056054
184myeloid dendritic cell activation (GO:0001773)2.55303292
185defense response to protozoan (GO:0042832)2.54827189
186lipoxygenase pathway (GO:0019372)2.53808099
187regulation of natural killer cell mediated immunity (GO:0002715)2.51867269
188regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.51867269
189regulation of platelet aggregation (GO:0090330)2.51745019
190phagosome maturation (GO:0090382)2.51525191
191barbed-end actin filament capping (GO:0051016)2.51500293
192myeloid dendritic cell differentiation (GO:0043011)2.51316902
193modulation by virus of host process (GO:0019054)2.49984792
194regulation of tolerance induction (GO:0002643)2.49522387
195regulation of T-helper 2 cell differentiation (GO:0045628)2.45957509
196regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.45950778
197regulation of antigen processing and presentation (GO:0002577)2.45486929
198germinal center formation (GO:0002467)2.44615364
199pentose-phosphate shunt (GO:0006098)2.44097284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72606016
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21203713
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16982454
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.91811636
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.83372694
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72572658
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.70435289
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.55874526
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.36383754
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.35415269
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07983301
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05913064
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01252935
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01100399
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93276387
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.69781349
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64446808
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61390743
19VDR_23849224_ChIP-Seq_CD4+_Human2.60965271
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55134428
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54598023
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.54329912
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.53543666
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50131632
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37730580
26* XRN2_22483619_ChIP-Seq_HELA_Human2.37040009
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31484905
28FOXP3_21729870_ChIP-Seq_TREG_Human2.29529409
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.27940245
30* DCP1A_22483619_ChIP-Seq_HELA_Human2.27875594
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23999522
32* VDR_24763502_ChIP-Seq_THP-1_Human2.18684938
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18311959
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15088613
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11570646
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11444806
37* GABP_19822575_ChIP-Seq_HepG2_Human2.10627205
38YY1_21170310_ChIP-Seq_MESCs_Mouse2.09094360
39* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07220901
40LXR_22292898_ChIP-Seq_THP-1_Human2.05733264
41FOXM1_23109430_ChIP-Seq_U2OS_Human2.02230542
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01713936
43MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01009175
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96757718
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.94224664
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94204906
47* MAF_26560356_Chip-Seq_TH1_Human1.94179718
48TTF2_22483619_ChIP-Seq_HELA_Human1.94089233
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93817523
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.93777967
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88016529
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87267099
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.84634069
54* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83066529
55* UTX_26944678_Chip-Seq_JUKART_Human1.83021364
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76819638
57SCL_19346495_ChIP-Seq_HPC-7_Human1.73769054
58* SPI1_23127762_ChIP-Seq_K562_Human1.71546275
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71113535
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70450480
61ELK1_19687146_ChIP-ChIP_HELA_Human1.70302182
62CIITA_25753668_ChIP-Seq_RAJI_Human1.69070939
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65706159
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64743345
65* MAF_26560356_Chip-Seq_TH2_Human1.64084902
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.63413554
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63399085
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63341026
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61618146
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59100601
71TCF7_22412390_ChIP-Seq_EML_Mouse1.57303884
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54417877
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54307805
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52961492
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52360615
76* KDM2B_26808549_Chip-Seq_DND41_Human1.48211009
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47986071
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47918405
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47388449
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46674017
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46492568
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46407930
83MYB_26560356_Chip-Seq_TH2_Human1.44420255
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44067726
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41944815
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.41720056
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40552810
88* BCL6_27268052_Chip-Seq_Bcells_Human1.40128229
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40035036
90* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37947450
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36484819
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.36481588
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36109864
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35408656
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35245720
96BCOR_27268052_Chip-Seq_Bcells_Human1.35012546
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33308822
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32342920
99AR_21909140_ChIP-Seq_LNCAP_Human1.31590400
100* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31386122
101MYB_26560356_Chip-Seq_TH1_Human1.30577449
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30377185
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.29340080
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28974079
105* RACK7_27058665_Chip-Seq_MCF-7_Human1.28896810
106P68_20966046_ChIP-Seq_HELA_Human1.28297431
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26868983
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.26682090
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25793633
110* NCOR1_26117541_ChIP-Seq_K562_Human1.24828165
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23484751
112* SPI1_23547873_ChIP-Seq_NB4_Human1.22237281
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21666842
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21455695
115KDM5A_27292631_Chip-Seq_BREAST_Human1.21241719
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.18410493
117* SA1_27219007_Chip-Seq_ERYTHROID_Human1.15632976
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14561591
119ELK1_22589737_ChIP-Seq_MCF10A_Human1.14254421
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13965561
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11202621
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09751898
123MYC_18940864_ChIP-ChIP_HL60_Human1.09707713
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09655574
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09285296
126FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08481427
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08307514
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08098656
129* GATA1_19941826_ChIP-Seq_K562_Human1.07832860
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07753052
131CTCF_26484167_Chip-Seq_Bcells_Mouse1.07129396
132* VDR_21846776_ChIP-Seq_THP-1_Human1.06621386
133* MYC_22102868_ChIP-Seq_BL_Human1.06512211
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05134027
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04079477
136CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02100947
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01496020
138PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00535579
139MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99090388
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98975144
141RUNX_20019798_ChIP-Seq_JUKART_Human0.98627624
142* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97928951
143* TFEB_21752829_ChIP-Seq_HELA_Human0.97106174
144* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96897398
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96682489
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95437117
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93626860
148CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93552610
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93464229
150FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91821797
151SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90469669
152* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89293646
153* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89148447
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88943202
155CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87888296
156DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86000972
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85453777
158IRF8_22096565_ChIP-ChIP_GC-B_Human0.83872278
159* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81408951
160KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80993662
161* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80245892
162* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79192471
163PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78752142
164TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78255261
165KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78053281
166YY1_22570637_ChIP-Seq_MALME-3M_Human0.75251683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.11957570
2MP0004957_abnormal_blastocyst_morpholog3.66177253
3MP0003303_peritoneal_inflammation3.53678514
4MP0010094_abnormal_chromosome_stability3.49514063
5MP0003111_abnormal_nucleus_morphology3.24263176
6MP0003077_abnormal_cell_cycle3.22704033
7MP0005058_abnormal_lysosome_morphology3.21462255
8MP0008057_abnormal_DNA_replication3.04659601
9MP0008058_abnormal_DNA_repair2.91334654
10MP0002396_abnormal_hematopoietic_system2.64467871
11MP0009379_abnormal_foot_pigmentation2.60980096
12MP0006082_CNS_inflammation2.55845624
13MP0005451_abnormal_body_composition2.38478608
14MP0003191_abnormal_cellular_cholesterol2.38009850
15MP0008007_abnormal_cellular_replicative2.34486617
16MP0003186_abnormal_redox_activity2.34130197
17MP0003763_abnormal_thymus_physiology2.28551189
18MP0006036_abnormal_mitochondrial_physio2.25444439
19MP0008932_abnormal_embryonic_tissue2.21862002
20MP0003172_abnormal_lysosome_physiology2.16598011
21MP0009333_abnormal_splenocyte_physiolog2.11393408
22MP0003300_gastrointestinal_ulcer2.08736562
23MP0001835_abnormal_antigen_presentation1.98191233
24MP0000490_abnormal_crypts_of1.96165956
25MP0003656_abnormal_erythrocyte_physiolo1.92446720
26MP0001533_abnormal_skeleton_physiology1.92268041
27MP0009278_abnormal_bone_marrow1.88714747
28MP0004147_increased_porphyrin_level1.85358030
29MP0003075_altered_response_to1.84124491
30MP0009840_abnormal_foam_cell1.82090071
31MP0002132_abnormal_respiratory_system1.81437275
32MP0009785_altered_susceptibility_to1.80447066
33MP0005671_abnormal_response_to1.77350811
34MP0004947_skin_inflammation1.75776265
35MP0003786_premature_aging1.73243089
36MP0004510_myositis1.71203209
37MP0005075_abnormal_melanosome_morpholog1.61659087
38MP0002398_abnormal_bone_marrow1.59457624
39MP0001529_abnormal_vocalization1.58906671
40MP0003806_abnormal_nucleotide_metabolis1.56883699
41MP0003724_increased_susceptibility_to1.55975475
42MP0002638_abnormal_pupillary_reflex1.55425760
43MP0008260_abnormal_autophagy1.53357419
44MP0001853_heart_inflammation1.52003799
45MP0003718_maternal_effect1.51822031
46MP0008877_abnormal_DNA_methylation1.49784678
47MP0001986_abnormal_taste_sensitivity1.48648755
48MP0000689_abnormal_spleen_morphology1.46883830
49MP0002722_abnormal_immune_system1.45483621
50MP0008004_abnormal_stomach_pH1.41505009
51MP0005397_hematopoietic_system_phenotyp1.40481767
52MP0001545_abnormal_hematopoietic_system1.40481767
53MP0002019_abnormal_tumor_incidence1.40220455
54MP0009764_decreased_sensitivity_to1.39987849
55MP0002148_abnormal_hypersensitivity_rea1.38082962
56MP0000685_abnormal_immune_system1.36845819
57MP0002429_abnormal_blood_cell1.35693485
58MP0000313_abnormal_cell_death1.32224322
59MP0002420_abnormal_adaptive_immunity1.32224195
60MP0005025_abnormal_response_to1.31320848
61MP0000604_amyloidosis1.30080978
62MP0001819_abnormal_immune_cell1.29049464
63MP0003828_pulmonary_edema1.29036901
64MP0003123_paternal_imprinting1.28785908
65MP0000716_abnormal_immune_system1.28595197
66MP0006035_abnormal_mitochondrial_morpho1.26543389
67MP0000350_abnormal_cell_proliferation1.25426920
68MP0002998_abnormal_bone_remodeling1.24815357
69MP0008789_abnormal_olfactory_epithelium1.24510226
70MP0002163_abnormal_gland_morphology1.24027915
71MP0005166_decreased_susceptibility_to1.22888426
72MP0002877_abnormal_melanocyte_morpholog1.22093588
73MP0000703_abnormal_thymus_morphology1.21725965
74MP0000372_irregular_coat_pigmentation1.21166639
75MP0000858_altered_metastatic_potential1.20743586
76MP0006054_spinal_hemorrhage1.19736840
77MP0005000_abnormal_immune_tolerance1.19528487
78MP0001730_embryonic_growth_arrest1.19118725
79MP0001800_abnormal_humoral_immune1.19050190
80MP0001764_abnormal_homeostasis1.18988691
81MP0002723_abnormal_immune_serum1.18455755
82MP0004808_abnormal_hematopoietic_stem1.16338040
83MP0000358_abnormal_cell_content/1.16187055
84MP0006292_abnormal_olfactory_placode1.15500949
85MP0003866_abnormal_defecation1.13137267
86MP0001905_abnormal_dopamine_level1.12471004
87MP0005310_abnormal_salivary_gland1.12355458
88MP0002452_abnormal_antigen_presenting1.12016884
89MP0002405_respiratory_system_inflammati1.11468717
90MP0003448_altered_tumor_morphology1.07536110
91MP0005408_hypopigmentation1.05877678
92MP0009763_increased_sensitivity_to1.02397460
93MP0003183_abnormal_peptide_metabolism1.01903951
94MP0001851_eye_inflammation1.00998427
95MP0002095_abnormal_skin_pigmentation0.98891672
96MP0005174_abnormal_tail_pigmentation0.97591134
97MP0002160_abnormal_reproductive_system0.95360971
98MP0001873_stomach_inflammation0.93789026
99MP0003329_amyloid_beta_deposits0.93221094
100MP0001663_abnormal_digestive_system0.92635739
101MP0002938_white_spotting0.91529190
102MP0002419_abnormal_innate_immunity0.90950786
103MP0008874_decreased_physiological_sensi0.90120750
104MP0005636_abnormal_mineral_homeostasis0.88882761
105MP0004858_abnormal_nervous_system0.87142176
106MP0002080_prenatal_lethality0.86457652
107MP0003453_abnormal_keratinocyte_physiol0.86210203
108MP0002653_abnormal_ependyma_morphology0.85900655
109MP0005165_increased_susceptibility_to0.85240093
110MP0000465_gastrointestinal_hemorrhage0.84902483
111MP0000015_abnormal_ear_pigmentation0.84574271
112MP0005390_skeleton_phenotype0.84564624
113MP0003646_muscle_fatigue0.82240107
114MP0005083_abnormal_biliary_tract0.81862405
115MP0001697_abnormal_embryo_size0.80992502
116MP0003436_decreased_susceptibility_to0.80473346
117MP0003705_abnormal_hypodermis_morpholog0.78227327
118MP0002166_altered_tumor_susceptibility0.77815382
119MP0001845_abnormal_inflammatory_respons0.76256370
120MP0003795_abnormal_bone_structure0.75635013
121MP0005464_abnormal_platelet_physiology0.75039818
122MP0009697_abnormal_copulation0.74988590
123MP0003566_abnormal_cell_adhesion0.74467183
124MP0002210_abnormal_sex_determination0.73957512
125MP0001790_abnormal_immune_system0.72828963
126MP0005387_immune_system_phenotype0.72828963
127MP0003690_abnormal_glial_cell0.72224853
128MP0003315_abnormal_perineum_morphology0.71990201
129MP0004883_abnormal_blood_vessel0.71740867
130MP0005584_abnormal_enzyme/coenzyme_acti0.71340413
131MP0003221_abnormal_cardiomyocyte_apopto0.70519348
132MP0001542_abnormal_bone_strength0.70507412
133MP0005379_endocrine/exocrine_gland_phen0.69973746
134MP0003567_abnormal_fetal_cardiomyocyte0.69192924
135MP0008469_abnormal_protein_level0.69116982
136MP0005319_abnormal_enzyme/_coenzyme0.68374385
137MP0001119_abnormal_female_reproductive0.68240233
138MP0009765_abnormal_xenobiotic_induced0.67882445
139MP0000343_altered_response_to0.66156574
140MP0002751_abnormal_autonomic_nervous0.66012489
141MP0005164_abnormal_response_to0.64511839
142MP0005266_abnormal_metabolism0.64505953
143MP0010155_abnormal_intestine_physiology0.64460114
144MP0002006_tumorigenesis0.63474033
145MP0004185_abnormal_adipocyte_glucose0.61490420
146MP0000249_abnormal_blood_vessel0.60517118
147MP0005381_digestive/alimentary_phenotyp0.55782214
148MP0004381_abnormal_hair_follicle0.55567958
149MP0002332_abnormal_exercise_endurance0.55494104

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.15966881
2Eczematoid dermatitis (HP:0000976)5.06869386
3Abnormal number of erythroid precursors (HP:0012131)5.03451938
4Abnormality of macrophages (HP:0004311)4.95459496
5Recurrent abscess formation (HP:0002722)4.84566776
6Recurrent bacterial skin infections (HP:0005406)4.63215709
7Acute necrotizing encephalopathy (HP:0006965)4.50181630
8Hepatocellular necrosis (HP:0001404)4.38881686
9Mitochondrial inheritance (HP:0001427)4.36274142
10Abnormal mitochondria in muscle tissue (HP:0008316)4.30410187
11Hepatic necrosis (HP:0002605)4.16468311
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.14111539
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.14111539
14Aplastic anemia (HP:0001915)4.12274801
15Chronic obstructive pulmonary disease (HP:0006510)4.09156708
16Obstructive lung disease (HP:0006536)4.09156708
17Abnormality of glycolipid metabolism (HP:0010969)4.06178287
18Abnormality of liposaccharide metabolism (HP:0010968)4.06178287
19Abnormality of glycosphingolipid metabolism (HP:0004343)4.06178287
20Increased CSF lactate (HP:0002490)3.98050366
21Reticulocytopenia (HP:0001896)3.89193056
22Purpura (HP:0000979)3.71422880
23Type I transferrin isoform profile (HP:0003642)3.71211962
24Myositis (HP:0100614)3.63366807
25Acute encephalopathy (HP:0006846)3.61936561
26Prolonged bleeding time (HP:0003010)3.57637749
27Mediastinal lymphadenopathy (HP:0100721)3.51426413
28Progressive macrocephaly (HP:0004481)3.45771483
29Increased hepatocellular lipid droplets (HP:0006565)3.42904207
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.41611261
31Recurrent gram-negative bacterial infections (HP:0005420)3.40765756
32Increased serum lactate (HP:0002151)3.30276948
33Stomatitis (HP:0010280)3.29373282
34Increased cerebral lipofuscin (HP:0011813)3.26376139
35Birth length less than 3rd percentile (HP:0003561)3.24840037
36Lipid accumulation in hepatocytes (HP:0006561)3.15716565
37Abnormality of the heme biosynthetic pathway (HP:0010472)3.14239427
38Hepatosplenomegaly (HP:0001433)3.12711171
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.12165811
40Orchitis (HP:0100796)3.11173794
413-Methylglutaconic aciduria (HP:0003535)3.10020596
42Meningitis (HP:0001287)3.08374267
43Macrocytic anemia (HP:0001972)3.06446298
44Exertional dyspnea (HP:0002875)3.05119762
45Recurrent fungal infections (HP:0002841)2.98954673
46Increased intramyocellular lipid droplets (HP:0012240)2.98882057
47Oral leukoplakia (HP:0002745)2.98676415
48Cellulitis (HP:0100658)2.98285520
49Epistaxis (HP:0000421)2.97524970
50Reduced antithrombin III activity (HP:0001976)2.95622294
51Dysostosis multiplex (HP:0000943)2.93823138
52Urticaria (HP:0001025)2.93491012
53Increased serum ferritin (HP:0003281)2.90555809
54Exercise intolerance (HP:0003546)2.89369115
55Recurrent skin infections (HP:0001581)2.89036481
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88034964
57Lactic acidosis (HP:0003128)2.87439720
58IgM deficiency (HP:0002850)2.84500920
59Cerebral hypomyelination (HP:0006808)2.83084802
60Respiratory difficulties (HP:0002880)2.82346138
61Spontaneous hematomas (HP:0007420)2.81439797
62Pallor (HP:0000980)2.81064896
63Vacuolated lymphocytes (HP:0001922)2.79913223
64Abnormal protein glycosylation (HP:0012346)2.77920500
65Abnormal glycosylation (HP:0012345)2.77920500
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77920500
67Abnormal protein N-linked glycosylation (HP:0012347)2.77920500
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.76950003
69Renal Fanconi syndrome (HP:0001994)2.76706286
70Gastrointestinal infarctions (HP:0005244)2.72408584
71Respiratory failure (HP:0002878)2.70710434
72Loss of speech (HP:0002371)2.70624992
73Thrombocytosis (HP:0001894)2.69882302
74Increased serum pyruvate (HP:0003542)2.66644116
75Abnormality of glycolysis (HP:0004366)2.66644116
76Microretrognathia (HP:0000308)2.64063068
77Increased muscle lipid content (HP:0009058)2.63724181
78Retrobulbar optic neuritis (HP:0100654)2.62174223
79Optic neuritis (HP:0100653)2.62174223
80Petechiae (HP:0000967)2.60718366
81Encephalitis (HP:0002383)2.60138505
82Recurrent viral infections (HP:0004429)2.59931381
83Elevated erythrocyte sedimentation rate (HP:0003565)2.59448928
84Increased IgM level (HP:0003496)2.57115540
85Gingivitis (HP:0000230)2.55429798
86Increased IgE level (HP:0003212)2.54275788
87Degeneration of anterior horn cells (HP:0002398)2.51438930
88Abnormality of the anterior horn cell (HP:0006802)2.51438930
89Breast hypoplasia (HP:0003187)2.50480237
90Amyloidosis (HP:0011034)2.48814277
91Hypertensive crisis (HP:0100735)2.48365841
92Gingival bleeding (HP:0000225)2.47713465
93Abnormality of iron homeostasis (HP:0011031)2.45713389
94Vasculitis (HP:0002633)2.44275362
95Gastrointestinal inflammation (HP:0004386)2.43536909
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42810683
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.41617649
98Abnormal platelet volume (HP:0011876)2.40504624
99Inflammation of the large intestine (HP:0002037)2.38528034
100Systemic lupus erythematosus (HP:0002725)2.38184612
101Chronic mucocutaneous candidiasis (HP:0002728)2.36468106
102Recurrent cutaneous fungal infections (HP:0011370)2.36468106
103Type 2 muscle fiber atrophy (HP:0003554)2.31945692
104Muscle fiber atrophy (HP:0100295)2.28980732
105Chest pain (HP:0100749)2.26798266
106Progressive neurologic deterioration (HP:0002344)2.23326767
107Microvesicular hepatic steatosis (HP:0001414)2.22672272
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18150540
109Poor head control (HP:0002421)2.17713079
110Colitis (HP:0002583)2.17508630
111Severe visual impairment (HP:0001141)2.16326198
112Cerebral edema (HP:0002181)2.16227257
113Optic disc pallor (HP:0000543)2.16184856
114Pancytopenia (HP:0001876)2.14558031
115Episodic fever (HP:0001954)2.14478771
116Ragged-red muscle fibers (HP:0003200)2.12541585
117Vertebral compression fractures (HP:0002953)2.12020482
118Granulocytopenia (HP:0001913)2.11115091
119Hypergammaglobulinemia (HP:0010702)2.11024396
120Impaired platelet aggregation (HP:0003540)2.10108897
121Abnormal platelet function (HP:0011869)2.10108897
12211 pairs of ribs (HP:0000878)2.09415719
123Rough bone trabeculation (HP:0100670)2.09180803
124Pulmonary infiltrates (HP:0002113)2.08478348
125Pustule (HP:0200039)2.07065531
126T lymphocytopenia (HP:0005403)2.06029658
127Cholecystitis (HP:0001082)2.03859915
128Abnormal gallbladder physiology (HP:0012438)2.03859915
129Carpal bone hypoplasia (HP:0001498)2.03077676
130Osteomyelitis (HP:0002754)2.02659607
131Agammaglobulinemia (HP:0004432)2.01345419
132Polycythemia (HP:0001901)2.00706567
133Leukodystrophy (HP:0002415)1.99535910
134CNS demyelination (HP:0007305)1.99516733
135Emotional lability (HP:0000712)1.98580971
136Gastrointestinal stroma tumor (HP:0100723)1.98477227
137Hypochromic anemia (HP:0001931)1.98025787
138Distal lower limb muscle weakness (HP:0009053)1.96591882
139Autoimmune thrombocytopenia (HP:0001973)1.95436697
140Generalized aminoaciduria (HP:0002909)1.95317277
141Menorrhagia (HP:0000132)1.95016195
142Abnormality of alanine metabolism (HP:0010916)1.93422897
143Hyperalaninemia (HP:0003348)1.93422897
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93422897
145Anorexia (HP:0002039)1.93084277
146Abnormality of polysaccharide metabolism (HP:0011012)1.92882095
147Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92882095
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92882095
149Abnormality of T cells (HP:0002843)1.92823353
150Interstitial pulmonary disease (HP:0006530)1.91430776
151Increased mean platelet volume (HP:0011877)1.89640183
152Abnormality of T cell number (HP:0011839)1.89500434
153Slow saccadic eye movements (HP:0000514)1.89200663
154Leukocytosis (HP:0001974)1.89110004
155Keratoconjunctivitis sicca (HP:0001097)1.88965848
156Microcytic anemia (HP:0001935)1.88932383
157Panhypogammaglobulinemia (HP:0003139)1.88804877
158Upper motor neuron abnormality (HP:0002127)1.88327079
159IgG deficiency (HP:0004315)1.87490418
160Hypochromic microcytic anemia (HP:0004840)1.87326797
161Hemoptysis (HP:0002105)1.87255931
162Axonal loss (HP:0003447)1.86812501
163Abnormality of the preputium (HP:0100587)1.86297004
164Abnormality of transition element cation homeostasis (HP:0011030)1.85471753
165Neuronal loss in central nervous system (HP:0002529)1.85441641
166Premature graying of hair (HP:0002216)1.84531176
167Hypertriglyceridemia (HP:0002155)1.83720419
168Glomerulopathy (HP:0100820)1.83526880
169Lymphopenia (HP:0001888)1.83222121
170Bone marrow hypocellularity (HP:0005528)1.82209435
171Multiple enchondromatosis (HP:0005701)1.81436015
172Patellar aplasia (HP:0006443)1.80576639
173Lymphoma (HP:0002665)1.79935025
174Colon cancer (HP:0003003)1.79555541
175Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79185524
176Pulmonary fibrosis (HP:0002206)1.78092306
177Hypothermia (HP:0002045)1.77857651
178Chronic otitis media (HP:0000389)1.77436179
179Neutropenia (HP:0001875)1.77253840
180B lymphocytopenia (HP:0010976)1.76998839
181Abnormality of B cell number (HP:0010975)1.76998839
182Abnormal lung lobation (HP:0002101)1.76719901
183Secondary amenorrhea (HP:0000869)1.76069343
184Abnormal rod and cone electroretinograms (HP:0008323)1.74899161
185Aplasia/Hypoplasia of the patella (HP:0006498)1.74301786
186Abnormality of T cell physiology (HP:0011840)1.74263739
187Unsteady gait (HP:0002317)1.71872116
188Meckel diverticulum (HP:0002245)1.70817955
189CNS hypomyelination (HP:0003429)1.69925899
190Abnormality of the ileum (HP:0001549)1.67729098
191Glycosuria (HP:0003076)1.64872186
192Abnormality of urine glucose concentration (HP:0011016)1.64872186
193Female pseudohermaphroditism (HP:0010458)1.64739639
194Myelodysplasia (HP:0002863)1.64540232
195Cellular immunodeficiency (HP:0005374)1.62936785
196Pancreatic cysts (HP:0001737)1.62098871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.40299963
2RIPK44.10056584
3STK164.08279595
4NME23.58913119
5EIF2AK13.33005485
6EIF2AK33.16354474
7ERN13.10075265
8WEE12.81402867
9PRPF4B2.62172763
10VRK12.43619247
11CDC72.37042680
12PIM22.33472891
13TESK22.18119822
14SRPK12.01927162
15FES1.90634241
16ARAF1.87817225
17GRK61.87798041
18BRSK21.85525193
19ACVR1B1.84720174
20SMG11.70592814
21CSK1.70340651
22TRIB31.69349919
23TAOK11.69225867
24KDR1.62060770
25TLK11.61550903
26TSSK61.56436899
27MAP3K121.56380501
28PLK41.53225997
29MAP4K11.51845289
30BRAF1.45525120
31TNK21.44027597
32NME11.43044504
33PASK1.42268013
34MAP2K31.37128397
35CCNB11.35914432
36RPS6KA41.35064511
37CDK191.30587049
38PBK1.30402673
39DYRK31.29290169
40TEC1.28475596
41MYLK1.27368543
42BRSK11.25080959
43MAP3K131.24018721
44MAP3K11.21560958
45CDK81.20136085
46MKNK11.18504662
47HCK1.18122378
48BCKDK1.16721294
49IRAK41.16681891
50FGR1.16310702
51EIF2AK21.12765698
52PLK11.12752115
53TESK11.12397342
54AURKB1.11848548
55AURKA1.11059751
56MAP3K141.10971680
57CSF1R1.06014714
58MAP3K111.06012833
59BTK1.05900837
60ZAP701.01609247
61EPHB11.00922578
62NEK20.98974224
63KIT0.98481495
64KSR20.97087164
65LIMK10.97017455
66TXK0.95926936
67SCYL20.93944821
68PLK30.93424669
69TGFBR10.92186067
70SIK30.89421835
71CDK70.88195044
72BMPR20.84586725
73ATR0.84428446
74BMX0.84109282
75MST40.83738650
76ILK0.82744071
77BLK0.82639546
78ZAK0.81829063
79FLT30.81650066
80JAK20.81097686
81PDPK10.81025011
82LCK0.78982493
83MAPKAPK50.78154639
84MAP3K50.78153326
85STK100.74774549
86RPS6KA50.74681448
87RPS6KB20.74581645
88TTK0.72771541
89MKNK20.72020655
90NEK10.71132028
91MATK0.70241154
92NLK0.70072925
93PDK10.69551579
94ITK0.68855336
95ADRBK20.68849492
96ABL20.68501531
97MAPK120.67820273
98SYK0.67753003
99MARK30.67148972
100STK40.66969160
101CSNK2A10.66747738
102DYRK20.66209774
103PRKD20.65937531
104CLK10.64041521
105IRAK20.63968617
106PAK10.63440024
107MOS0.63410554
108TYK20.62789628
109LRRK20.62730926
110MAPKAPK30.62527383
111MUSK0.61683824
112SIK10.61113624
113CHEK20.61067000
114MARK20.55872663
115JAK10.55787619
116ICK0.55728042
117GRK70.55436248
118MAP3K80.55250281
119PIM10.54611013
120DAPK10.54197911
121TAOK30.54122383
122PAK40.53583043
123CSNK2A20.52960730
124VRK20.52451229
125LYN0.51988361
126IRAK30.49828420
127PTK60.49513386
128TTN0.49255420
129TGFBR20.48078830
130PRKCI0.47591253
131RAF10.47190458
132CDK40.47169719
133TAOK20.46164433
134DAPK30.45737630
135MAPK110.45733234
136TBK10.44191139
137IKBKE0.42907107
138CAMKK20.41922714
139JAK30.41484704
140PRKG20.41459016
141FYN0.41448582
142STK240.41311673
143EEF2K0.40723891
144IKBKB0.40251295
145HIPK20.39761033
146RPS6KC10.39711020
147RPS6KL10.39711020
148MAP2K60.38935006
149CDC42BPA0.38227405
150BMPR1B0.37893400
151GRK50.36916397
152CSNK1G30.36530393
153MAP3K30.35629158
154MAPKAPK20.35488467
155RIPK10.34734068

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.55670453
2Proteasome_Homo sapiens_hsa030504.48968852
3DNA replication_Homo sapiens_hsa030304.40496083
4Mismatch repair_Homo sapiens_hsa034303.49846905
5RNA polymerase_Homo sapiens_hsa030203.35394281
6Oxidative phosphorylation_Homo sapiens_hsa001902.90644118
7Base excision repair_Homo sapiens_hsa034102.83259245
8Protein export_Homo sapiens_hsa030602.79828200
9Parkinsons disease_Homo sapiens_hsa050122.73172153
10Pyrimidine metabolism_Homo sapiens_hsa002402.62940450
11Homologous recombination_Homo sapiens_hsa034402.61093444
12Nucleotide excision repair_Homo sapiens_hsa034202.59552618
13Osteoclast differentiation_Homo sapiens_hsa043802.58097715
14Spliceosome_Homo sapiens_hsa030402.49488177
15Staphylococcus aureus infection_Homo sapiens_hsa051502.31656414
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28092187
17Toll-like receptor signaling pathway_Homo sapiens_hsa046202.06747433
18Huntingtons disease_Homo sapiens_hsa050162.02981380
19B cell receptor signaling pathway_Homo sapiens_hsa046622.00910450
20Tuberculosis_Homo sapiens_hsa051521.98514283
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94332555
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90253893
23Lysosome_Homo sapiens_hsa041421.87195187
24RNA transport_Homo sapiens_hsa030131.86397556
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85797399
26Viral myocarditis_Homo sapiens_hsa054161.83199503
27Cell cycle_Homo sapiens_hsa041101.81258321
28Basal transcription factors_Homo sapiens_hsa030221.71685362
29Type I diabetes mellitus_Homo sapiens_hsa049401.66034792
30Malaria_Homo sapiens_hsa051441.63658996
31Alzheimers disease_Homo sapiens_hsa050101.62056630
32Non-homologous end-joining_Homo sapiens_hsa034501.60902731
33RNA degradation_Homo sapiens_hsa030181.60094526
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56166593
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55788850
36Acute myeloid leukemia_Homo sapiens_hsa052211.53045162
37Purine metabolism_Homo sapiens_hsa002301.51792961
38Salmonella infection_Homo sapiens_hsa051321.48793702
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48701835
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.39366689
41Toxoplasmosis_Homo sapiens_hsa051451.38710776
42Fanconi anemia pathway_Homo sapiens_hsa034601.38304461
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37864454
44Folate biosynthesis_Homo sapiens_hsa007901.32636713
45Influenza A_Homo sapiens_hsa051641.32633950
46Chemokine signaling pathway_Homo sapiens_hsa040621.27996550
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25936795
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23649148
49T cell receptor signaling pathway_Homo sapiens_hsa046601.22896737
50Primary immunodeficiency_Homo sapiens_hsa053401.22001498
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19152343
52Pertussis_Homo sapiens_hsa051331.18034774
53Sulfur relay system_Homo sapiens_hsa041221.17067920
54One carbon pool by folate_Homo sapiens_hsa006701.15185412
55Platelet activation_Homo sapiens_hsa046111.08121482
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07028038
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05315544
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04499883
59TNF signaling pathway_Homo sapiens_hsa046681.03317822
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.01238816
61Endocytosis_Homo sapiens_hsa041441.01074623
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00789110
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00228016
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99858291
65Non-small cell lung cancer_Homo sapiens_hsa052230.99595597
66Pentose phosphate pathway_Homo sapiens_hsa000300.98226062
67p53 signaling pathway_Homo sapiens_hsa041150.95528887
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94417571
69Epstein-Barr virus infection_Homo sapiens_hsa051690.92927144
70Hepatitis B_Homo sapiens_hsa051610.90990111
71Pancreatic cancer_Homo sapiens_hsa052120.88976647
72VEGF signaling pathway_Homo sapiens_hsa043700.86445763
73N-Glycan biosynthesis_Homo sapiens_hsa005100.86228822
74Bladder cancer_Homo sapiens_hsa052190.85886782
75Chronic myeloid leukemia_Homo sapiens_hsa052200.84634395
76Hepatitis C_Homo sapiens_hsa051600.81991024
77Glutathione metabolism_Homo sapiens_hsa004800.81163771
78African trypanosomiasis_Homo sapiens_hsa051430.80414729
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.79400736
80Antigen processing and presentation_Homo sapiens_hsa046120.78338072
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71234327
82Herpes simplex infection_Homo sapiens_hsa051680.67930865
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.67551150
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.66741910
85Systemic lupus erythematosus_Homo sapiens_hsa053220.64788289
86Regulation of autophagy_Homo sapiens_hsa041400.63292450
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62381254
88Prion diseases_Homo sapiens_hsa050200.62160811
89mRNA surveillance pathway_Homo sapiens_hsa030150.61684033
90Metabolic pathways_Homo sapiens_hsa011000.61629311
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.60325161
92Cardiac muscle contraction_Homo sapiens_hsa042600.59028017
93Synaptic vesicle cycle_Homo sapiens_hsa047210.58577861
94Vitamin B6 metabolism_Homo sapiens_hsa007500.58215653
95Other glycan degradation_Homo sapiens_hsa005110.56183519
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.55962721
97Legionellosis_Homo sapiens_hsa051340.55880622
98Carbon metabolism_Homo sapiens_hsa012000.54463015
99Biosynthesis of amino acids_Homo sapiens_hsa012300.52488874
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52232227
101Arachidonic acid metabolism_Homo sapiens_hsa005900.51609910
102Hematopoietic cell lineage_Homo sapiens_hsa046400.48619863
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.48311344
104Galactose metabolism_Homo sapiens_hsa000520.45798394
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45269604
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44959841
107HIF-1 signaling pathway_Homo sapiens_hsa040660.44847815
108Thyroid cancer_Homo sapiens_hsa052160.44643914
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.42796707
110Vibrio cholerae infection_Homo sapiens_hsa051100.42731163
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40889442
112Fatty acid elongation_Homo sapiens_hsa000620.40120245
113Renal cell carcinoma_Homo sapiens_hsa052110.39889159
114Measles_Homo sapiens_hsa051620.39685931
115Allograft rejection_Homo sapiens_hsa053300.38747921
116Amoebiasis_Homo sapiens_hsa051460.37831540
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37072571
118Shigellosis_Homo sapiens_hsa051310.36469905
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36456430
120Asthma_Homo sapiens_hsa053100.36000438
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34519179
122Pyruvate metabolism_Homo sapiens_hsa006200.33309988
123Viral carcinogenesis_Homo sapiens_hsa052030.32963018
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.32930653
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.32473829
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30713522
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30580338
128Fructose and mannose metabolism_Homo sapiens_hsa000510.30234935
129Collecting duct acid secretion_Homo sapiens_hsa049660.30089340
130Oocyte meiosis_Homo sapiens_hsa041140.29689478
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29059845
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.28623582
133Alcoholism_Homo sapiens_hsa050340.27858892
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27444050
135Notch signaling pathway_Homo sapiens_hsa043300.26550596
136Apoptosis_Homo sapiens_hsa042100.25738642
137Phototransduction_Homo sapiens_hsa047440.25258846
138HTLV-I infection_Homo sapiens_hsa051660.24878134
139Selenocompound metabolism_Homo sapiens_hsa004500.23824295
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23164857
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.20556687
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20485368
143Leishmaniasis_Homo sapiens_hsa051400.20444371
144Graft-versus-host disease_Homo sapiens_hsa053320.18274177
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18057342
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17096790
147Arginine and proline metabolism_Homo sapiens_hsa003300.16488557
148Linoleic acid metabolism_Homo sapiens_hsa005910.15597420
149Phagosome_Homo sapiens_hsa041450.15597056
150Autoimmune thyroid disease_Homo sapiens_hsa053200.15051150
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.14845115
152Rheumatoid arthritis_Homo sapiens_hsa053230.14627950
153Renin-angiotensin system_Homo sapiens_hsa046140.14180056

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