OAZ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.42527565
2nucleobase catabolic process (GO:0046113)5.55739967
3regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.88039288
4synaptic vesicle maturation (GO:0016188)4.56683424
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.37060616
6regulation of synapse structural plasticity (GO:0051823)4.26052639
7behavioral response to nicotine (GO:0035095)4.25534512
8cell communication by electrical coupling (GO:0010644)4.24273213
9regulation of posttranscriptional gene silencing (GO:0060147)4.18511543
10regulation of gene silencing by miRNA (GO:0060964)4.18511543
11regulation of gene silencing by RNA (GO:0060966)4.18511543
12postsynaptic membrane organization (GO:0001941)4.10681437
13positive regulation of mitochondrial fission (GO:0090141)4.10159313
14establishment of mitochondrion localization (GO:0051654)4.05280720
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97758275
16presynaptic membrane assembly (GO:0097105)3.82748522
17activation of protein kinase A activity (GO:0034199)3.80239851
18plasma membrane repair (GO:0001778)3.76959353
19nonmotile primary cilium assembly (GO:0035058)3.76566839
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.75545188
21neurofilament cytoskeleton organization (GO:0060052)3.74027010
22synaptic vesicle exocytosis (GO:0016079)3.72212432
23presynaptic membrane organization (GO:0097090)3.69378465
24locomotory exploration behavior (GO:0035641)3.69374646
25negative regulation of oligodendrocyte differentiation (GO:0048715)3.62436801
26neuron cell-cell adhesion (GO:0007158)3.62172189
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.58933448
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.56246851
29axonal fasciculation (GO:0007413)3.54903798
30negative regulation of potassium ion transmembrane transport (GO:1901380)3.53200430
31layer formation in cerebral cortex (GO:0021819)3.52841692
32regulation of synaptic vesicle exocytosis (GO:2000300)3.52131510
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50204918
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.46366310
35axon extension involved in axon guidance (GO:0048846)3.46366310
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.43705819
37cell communication involved in cardiac conduction (GO:0086065)3.40977480
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.40000742
39regulation of collateral sprouting (GO:0048670)3.39664887
40sequestering of actin monomers (GO:0042989)3.39610647
41sodium ion export (GO:0071436)3.38851426
42head development (GO:0060322)3.38167840
43chaperone-mediated protein transport (GO:0072321)3.37747561
44glutamate secretion (GO:0014047)3.37616438
45regulation of membrane repolarization (GO:0060306)3.36407946
46regulation of cilium movement (GO:0003352)3.35218505
47regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.33901203
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.30440208
49regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.30274426
50short-term memory (GO:0007614)3.30000071
51cellular potassium ion homeostasis (GO:0030007)3.29680597
52regulation of synaptic vesicle transport (GO:1902803)3.24042428
53negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.21992544
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19839825
55vocalization behavior (GO:0071625)3.17665422
56regulation of mitochondrial fission (GO:0090140)3.16406335
57potassium ion import (GO:0010107)3.13961706
58olfactory bulb development (GO:0021772)3.10814937
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09727944
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05398955
61positive regulation of potassium ion transmembrane transport (GO:1901381)3.04280962
62neuron recognition (GO:0008038)3.04078597
63negative regulation of telomere maintenance (GO:0032205)3.01291235
64negative regulation of cytosolic calcium ion concentration (GO:0051481)2.99460912
65membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.98339032
66negative regulation of microtubule polymerization (GO:0031115)2.96641592
67respiratory system process (GO:0003016)2.95907691
68calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.94902099
69positive regulation of synapse maturation (GO:0090129)2.94269252
70cardiac myofibril assembly (GO:0055003)2.94262989
71membrane repolarization (GO:0086009)2.93457421
72protein polyglutamylation (GO:0018095)2.93121105
73synaptic transmission, glutamatergic (GO:0035249)2.92759248
74protein localization to cilium (GO:0061512)2.91119974
75hippocampus development (GO:0021766)2.91117520
76cardiac muscle contraction (GO:0060048)2.90675918
77transmission of nerve impulse (GO:0019226)2.90666872
78sarcomere organization (GO:0045214)2.89406759
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89236862
80synapse assembly (GO:0007416)2.88695934
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85639899
82tricarboxylic acid cycle (GO:0006099)2.83971055
83dendritic spine morphogenesis (GO:0060997)2.82728358
84L-serine metabolic process (GO:0006563)2.82192912
85neurotransmitter secretion (GO:0007269)2.81191338
86regulation of telomere maintenance via telomerase (GO:0032210)2.79532718
87retinal ganglion cell axon guidance (GO:0031290)2.79078101
88somite development (GO:0061053)2.78611642
89growth hormone secretion (GO:0030252)2.78159586
90regulation of calcium ion transmembrane transporter activity (GO:1901019)2.77512509
91regulation of calcium ion transmembrane transport (GO:1903169)2.77512509
92adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.77091227
93positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76660688
94detection of calcium ion (GO:0005513)2.76573846
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76472223
96mitochondrion transport along microtubule (GO:0047497)2.76472223
97gamma-aminobutyric acid transport (GO:0015812)2.76015787
98exploration behavior (GO:0035640)2.74709257
99membrane repolarization during action potential (GO:0086011)2.72812305
100substrate-independent telencephalic tangential migration (GO:0021826)2.72695536
101substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.72695536
102epithelial cilium movement (GO:0003351)2.71292318
103protein targeting to plasma membrane (GO:0072661)2.70606693
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70539480
105spinal cord development (GO:0021510)2.70438069
106neuromuscular synaptic transmission (GO:0007274)2.68755589
107establishment of melanosome localization (GO:0032401)2.68242630
108regulation of glutamate receptor signaling pathway (GO:1900449)2.67921927
109regulation of potassium ion transmembrane transport (GO:1901379)2.67352635
110synaptic transmission, cholinergic (GO:0007271)2.66927832
111neuronal action potential propagation (GO:0019227)2.66555940
112positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.66513137
113positive regulation of potassium ion transport (GO:0043268)2.66394823
114dendrite development (GO:0016358)2.66203867
115regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.65788731
116membrane depolarization during action potential (GO:0086010)2.65074074
117ubiquinone metabolic process (GO:0006743)2.64506871
118negative regulation of potassium ion transport (GO:0043267)2.63907322
119auditory behavior (GO:0031223)2.63003011
120regulation of microtubule-based movement (GO:0060632)2.62242001
121cell migration in hindbrain (GO:0021535)2.62211114
122potassium ion homeostasis (GO:0055075)2.62115623
123epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60709391
124sarcoplasmic reticulum calcium ion transport (GO:0070296)2.60475498
125regulation of neuronal synaptic plasticity (GO:0048168)2.59542436
126negative regulation of calcium ion transmembrane transport (GO:1903170)2.58858169
127negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.58858169
128neuromuscular process controlling posture (GO:0050884)2.58734862
129neuronal ion channel clustering (GO:0045161)2.58593513
130positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58204116
131serine family amino acid catabolic process (GO:0009071)2.58095587
132response to misfolded protein (GO:0051788)2.57077480
133ventricular cardiac muscle cell action potential (GO:0086005)2.56775145
134regulation of cell communication by electrical coupling (GO:0010649)2.56243667
135establishment of pigment granule localization (GO:0051905)2.55213612
136regulation of feeding behavior (GO:0060259)2.55034408
137synapse organization (GO:0050808)2.54879307
138regulation of synaptic transmission, dopaminergic (GO:0032225)2.54240911
139calcium-mediated signaling using intracellular calcium source (GO:0035584)2.53289727
140response to pheromone (GO:0019236)2.52981567
141regulation of potassium ion transmembrane transporter activity (GO:1901016)2.52828650
142melanosome transport (GO:0032402)2.52072592
143actin-myosin filament sliding (GO:0033275)2.51946838
144muscle filament sliding (GO:0030049)2.51946838
145potassium ion export (GO:0071435)2.51917936
146cellular sodium ion homeostasis (GO:0006883)2.51913200
147regulation of sodium ion transmembrane transporter activity (GO:2000649)2.50260165
148histone arginine methylation (GO:0034969)2.50162373
149synaptic vesicle endocytosis (GO:0048488)2.48973386
150melanosome localization (GO:0032400)2.48865059
151regulation of development, heterochronic (GO:0040034)2.47940701
152myofibril assembly (GO:0030239)2.47395037
153neuromuscular process controlling balance (GO:0050885)2.46575587
154ATP hydrolysis coupled proton transport (GO:0015991)2.46570593
155energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.46570593
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46188560
157negative regulation of axonogenesis (GO:0050771)2.45928019
158respiratory burst (GO:0045730)2.45045004
159vesicle transport along microtubule (GO:0047496)2.44620182
160regulation of long-term neuronal synaptic plasticity (GO:0048169)2.44485804
161membrane hyperpolarization (GO:0060081)2.44235858
162positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.44096116
163positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.44064616
164forebrain neuron differentiation (GO:0021879)2.43951259
165spinal cord association neuron differentiation (GO:0021527)2.43134573
166protein localization to synapse (GO:0035418)2.43120038
167neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.42700604
168innervation (GO:0060384)2.42494921
169behavioral response to cocaine (GO:0048148)2.41893975
170positive regulation of sodium ion transport (GO:0010765)2.41268176
171axon extension (GO:0048675)2.40705642
172positive regulation of axon extension (GO:0045773)2.40420819
173proline transport (GO:0015824)2.40339441
174surfactant homeostasis (GO:0043129)2.40302461
175cardiac muscle cell action potential involved in contraction (GO:0086002)2.40134399
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.37109560
177heart trabecula formation (GO:0060347)2.36520680
178cerebellar Purkinje cell layer development (GO:0021680)2.35968278
179regulation of sodium ion transmembrane transport (GO:1902305)2.35864971
180regulation of early endosome to late endosome transport (GO:2000641)2.35530640
181regulation of heart rate by cardiac conduction (GO:0086091)2.34822047
182cardiac muscle cell action potential (GO:0086001)2.34207752
183establishment of nucleus localization (GO:0040023)2.33788637
184regulation of cation channel activity (GO:2001257)2.33313752
185axon cargo transport (GO:0008088)2.31936304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.69079376
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66712681
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59438571
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48012333
5SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47169631
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47156381
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47156381
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43035637
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38848433
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32383292
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31835443
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.28287176
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.20510750
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.17478472
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17336350
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14591484
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08814315
18* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.08257106
19DROSHA_22980978_ChIP-Seq_HELA_Human2.05447655
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03582530
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.02650556
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.00365771
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.98961702
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95485636
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91071525
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.89161915
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86323390
28REST_21632747_ChIP-Seq_MESCs_Mouse1.84290340
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.82534723
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82006938
31IGF1R_20145208_ChIP-Seq_DFB_Human1.80857488
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.78047114
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77827997
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77240731
35ZNF274_21170338_ChIP-Seq_K562_Hela1.76258932
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.73628023
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72463375
38ZNF263_19887448_ChIP-Seq_K562_Human1.70225859
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.69499098
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.64206092
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64152215
42KDM2B_26808549_Chip-Seq_K562_Human1.61698314
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60164669
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60080867
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60011834
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.53502866
47IRF1_19129219_ChIP-ChIP_H3396_Human1.52617587
48* SOX2_16153702_ChIP-ChIP_HESCs_Human1.50922067
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47019478
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.46905464
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42721155
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41100234
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39914836
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39883359
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39439747
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39274776
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36904868
58CTCF_27219007_Chip-Seq_Bcells_Human1.35216937
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34993699
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33801603
61LXR_22292898_ChIP-Seq_THP-1_Human1.33780888
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33716940
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.32015385
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31523798
65CLOCK_20551151_ChIP-Seq_293T_Human1.31430662
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31382004
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30917273
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30917273
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30917273
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30490949
71* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29757028
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29681571
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29681416
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27694367
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25838379
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.24043819
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21784100
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21728036
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.21587150
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21393242
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.21018432
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20178227
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19892156
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.18286312
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.18286312
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18272026
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18084782
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18013135
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17938011
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17268251
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16688303
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16017174
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15813814
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15161405
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14595604
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.13588099
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13052260
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.09845537
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08753444
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08085329
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07461122
102* SMC4_20622854_ChIP-Seq_HELA_Human1.05248272
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.02967252
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02503097
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00629386
106GBX2_23144817_ChIP-Seq_PC3_Human1.00106658
107KDM2B_26808549_Chip-Seq_DND41_Human0.97096032
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96602611
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96579781
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.95431398
111BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94585956
112CREB1_26743006_Chip-Seq_LNCaP_Human0.94278932
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93936320
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93888715
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93613887
116KLF4_19829295_ChIP-Seq_ESCs_Human0.93402697
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.93219783
118AR_19668381_ChIP-Seq_PC3_Human0.92757467
119RNF2_27304074_Chip-Seq_NSC_Mouse0.92648861
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92627220
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92467197
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91688149
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91525127
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91003500
125NANOG_20526341_ChIP-Seq_ESCs_Human0.90342424
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90181697
127RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88117135
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87491326
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87491326
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86985036
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86929594
132SA1_27219007_Chip-Seq_Bcells_Human0.86587921
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86482598
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85561413
135CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84434603
136POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84345605
137* SMAD4_21741376_ChIP-Seq_HESCs_Human0.83926164
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.83856477
139* NANOG_16153702_ChIP-ChIP_HESCs_Human0.83589469
140ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83537556
141* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83477802
142ELK3_25401928_ChIP-Seq_HUVEC_Human0.82714797
143OCT4_19829295_ChIP-Seq_ESCs_Human0.82001934
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81707079
145P68_20966046_ChIP-Seq_HELA_Human0.81161088
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80875167
147MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.80509287
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.80154198
149TP63_22573176_ChIP-Seq_HFKS_Human0.79898296
150* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79839276
151RACK7_27058665_Chip-Seq_MCF-7_Human0.79204173
152TP53_23651856_ChIP-Seq_MEFs_Mouse0.78869973
153KDM2B_26808549_Chip-Seq_JURKAT_Human0.77933637
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77407132
155NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77348483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.95712685
2MP0000751_myopathy3.54037458
3MP0002837_dystrophic_cardiac_calcinosis3.23688625
4MP0004084_abnormal_cardiac_muscle2.75126181
5MP0002254_reproductive_system_inflammat2.74039415
6MP0003787_abnormal_imprinting2.65701102
7MP0001529_abnormal_vocalization2.55056378
8MP0004270_analgesia2.47207116
9MP0003635_abnormal_synaptic_transmissio2.46462081
10MP0002909_abnormal_adrenal_gland2.45933076
11MP0004215_abnormal_myocardial_fiber2.45926239
12MP0004858_abnormal_nervous_system2.44532881
13MP0000013_abnormal_adipose_tissue2.40423233
14MP0004036_abnormal_muscle_relaxation2.34579220
15MP0003646_muscle_fatigue2.29205757
16MP0004145_abnormal_muscle_electrophysio2.25871185
17MP0005394_taste/olfaction_phenotype2.21541526
18MP0005499_abnormal_olfactory_system2.21541526
19MP0002102_abnormal_ear_morphology2.10995807
20MP0008789_abnormal_olfactory_epithelium2.07063473
21MP0003136_yellow_coat_color2.06813200
22MP0003121_genomic_imprinting2.02349353
23MP0000749_muscle_degeneration1.96604525
24MP0003122_maternal_imprinting1.93612557
25MP0003880_abnormal_central_pattern1.92131817
26MP0001968_abnormal_touch/_nociception1.88338915
27MP0002063_abnormal_learning/memory/cond1.84928102
28MP0004133_heterotaxia1.84228455
29MP0010368_abnormal_lymphatic_system1.82272235
30MP0000049_abnormal_middle_ear1.81206738
31MP0009780_abnormal_chondrocyte_physiolo1.79143383
32MP0002734_abnormal_mechanical_nocicepti1.73923402
33MP0006292_abnormal_olfactory_placode1.71627969
34MP0005620_abnormal_muscle_contractility1.66641880
35MP0004233_abnormal_muscle_weight1.66436426
36MP0002735_abnormal_chemical_nociception1.62009343
37MP0005330_cardiomyopathy1.60634562
38MP0000747_muscle_weakness1.60403933
39MP0002733_abnormal_thermal_nociception1.60387817
40MP0004087_abnormal_muscle_fiber1.60248831
41MP0002972_abnormal_cardiac_muscle1.57434649
42MP0004130_abnormal_muscle_cell1.57123580
43MP0006276_abnormal_autonomic_nervous1.56470029
44MP0001293_anophthalmia1.55293137
45MP0010030_abnormal_orbit_morphology1.53880325
46MP0002822_catalepsy1.53491783
47MP0004085_abnormal_heartbeat1.53107245
48MP0009745_abnormal_behavioral_response1.51394709
49MP0008877_abnormal_DNA_methylation1.48929382
50MP0008961_abnormal_basal_metabolism1.47793793
51MP0005167_abnormal_blood-brain_barrier1.47723387
52MP0003137_abnormal_impulse_conducting1.46803893
53MP0001958_emphysema1.45482958
54MP0002064_seizures1.45101586
55MP0003329_amyloid_beta_deposits1.44961341
56MP0004484_altered_response_of1.44843975
57MP0003938_abnormal_ear_development1.44246539
58MP0000750_abnormal_muscle_regeneration1.42767259
59MP0002106_abnormal_muscle_physiology1.42706304
60MP0002269_muscular_atrophy1.42244509
61MP0004272_abnormal_basement_membrane1.41330514
62MP0001970_abnormal_pain_threshold1.38926917
63MP0004142_abnormal_muscle_tone1.37796574
64MP0000759_abnormal_skeletal_muscle1.37282335
65MP0003011_delayed_dark_adaptation1.37250328
66MP0002736_abnormal_nociception_after1.35911035
67MP0005623_abnormal_meninges_morphology1.35709947
68MP0003283_abnormal_digestive_organ1.34794743
69MP0005377_hearing/vestibular/ear_phenot1.34199130
70MP0003878_abnormal_ear_physiology1.34199130
71MP0002572_abnormal_emotion/affect_behav1.32645498
72MP0005423_abnormal_somatic_nervous1.31978154
73MP0002184_abnormal_innervation1.31368733
74MP0003119_abnormal_digestive_system1.31336459
75MP0006138_congestive_heart_failure1.31101639
76MP0002272_abnormal_nervous_system1.29987365
77MP0002234_abnormal_pharynx_morphology1.28960865
78MP0001485_abnormal_pinna_reflex1.27977897
79MP0003221_abnormal_cardiomyocyte_apopto1.26885417
80MP0005369_muscle_phenotype1.24775310
81MP0008775_abnormal_heart_ventricle1.24662675
82MP0004811_abnormal_neuron_physiology1.24426373
83MP0003879_abnormal_hair_cell1.23155042
84MP0006072_abnormal_retinal_apoptosis1.21410835
85MP0003724_increased_susceptibility_to1.21237820
86MP0001984_abnormal_olfaction1.20383883
87MP0000534_abnormal_ureter_morphology1.19514859
88MP0002152_abnormal_brain_morphology1.18274386
89MP0005385_cardiovascular_system_phenoty1.17689870
90MP0001544_abnormal_cardiovascular_syste1.17689870
91MP0009046_muscle_twitch1.17093792
92MP0001188_hyperpigmentation1.16831634
93MP0002752_abnormal_somatic_nervous1.16534923
94MP0002638_abnormal_pupillary_reflex1.16352326
95MP0001440_abnormal_grooming_behavior1.16217594
96MP0001879_abnormal_lymphatic_vessel1.13930510
97MP0005187_abnormal_penis_morphology1.12381808
98MP0003279_aneurysm1.11479873
99MP0000003_abnormal_adipose_tissue1.10614175
100MP0008569_lethality_at_weaning1.08031474
101MP0005248_abnormal_Harderian_gland1.06672214
102MP0000955_abnormal_spinal_cord1.06451735
103MP0002557_abnormal_social/conspecific_i1.05926685
104MP0004043_abnormal_pH_regulation1.04722921
105MP0004742_abnormal_vestibular_system1.04458617
106MP0001486_abnormal_startle_reflex1.03550036
107MP0005253_abnormal_eye_physiology1.02337683
108MP0004885_abnormal_endolymph1.00211258
109MP0005084_abnormal_gallbladder_morpholo0.99990564
110MP0000026_abnormal_inner_ear0.99530823
111MP0003861_abnormal_nervous_system0.99188941
112MP0002067_abnormal_sensory_capabilities0.97676731
113MP0010630_abnormal_cardiac_muscle0.94960024
114MP0001986_abnormal_taste_sensitivity0.94245447
115MP0002751_abnormal_autonomic_nervous0.94217392
116MP0001963_abnormal_hearing_physiology0.91915325
117MP0003890_abnormal_embryonic-extraembry0.91878736
118MP0003690_abnormal_glial_cell0.91466251
119MP0001905_abnormal_dopamine_level0.90687969
120MP0002882_abnormal_neuron_morphology0.87989700
121MP0005386_behavior/neurological_phenoty0.87800628
122MP0004924_abnormal_behavior0.87800628
123MP0002653_abnormal_ependyma_morphology0.87420263
124MP0001299_abnormal_eye_distance/0.87099665
125MP0001502_abnormal_circadian_rhythm0.86989551
126MP0000778_abnormal_nervous_system0.86253677
127MP0000631_abnormal_neuroendocrine_gland0.85103468
128MP0010386_abnormal_urinary_bladder0.84606017
129MP0003567_abnormal_fetal_cardiomyocyte0.84218158
130MP0002066_abnormal_motor_capabilities/c0.83740876
131MP0002332_abnormal_exercise_endurance0.83356253
132MP0002277_abnormal_respiratory_mucosa0.81114095
133MP0003633_abnormal_nervous_system0.80979663
134MP0002108_abnormal_muscle_morphology0.80894902
135MP0000230_abnormal_systemic_arterial0.79301866
136MP0005595_abnormal_vascular_smooth0.78621294
137MP0006035_abnormal_mitochondrial_morpho0.77548156
138MP0005165_increased_susceptibility_to0.75425805
139MP0002069_abnormal_eating/drinking_beha0.75242721
140MP0008260_abnormal_autophagy0.74027574
141MP0005646_abnormal_pituitary_gland0.73836878
142MP0000537_abnormal_urethra_morphology0.73779136
143MP0002127_abnormal_cardiovascular_syste0.73727084
144MP0001270_distended_abdomen0.73562540
145MP0002295_abnormal_pulmonary_circulatio0.72945729
146MP0005391_vision/eye_phenotype0.71666047
147MP0000566_synostosis0.71166291
148MP0001501_abnormal_sleep_pattern0.70656477
149MP0005195_abnormal_posterior_eye0.70583733
150MP0004510_myositis0.70577607
151MP0005645_abnormal_hypothalamus_physiol0.66308376

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)5.07440580
2Myokymia (HP:0002411)3.98120024
3Sudden death (HP:0001699)3.86549798
4Exercise-induced myalgia (HP:0003738)3.85643050
5Cortical dysplasia (HP:0002539)3.64742409
6Gait imbalance (HP:0002141)3.42737916
7Exercise-induced muscle cramps (HP:0003710)3.33912810
8Pheochromocytoma (HP:0002666)3.31880134
9Visual hallucinations (HP:0002367)3.27074738
10Bundle branch block (HP:0011710)3.23830087
11Abnormality of the labia minora (HP:0012880)3.22414859
12Ventricular fibrillation (HP:0001663)3.16808846
13Congenital primary aphakia (HP:0007707)3.15763921
14Medial flaring of the eyebrow (HP:0010747)3.12121727
15Nephrogenic diabetes insipidus (HP:0009806)3.00248587
16Hyperglycinemia (HP:0002154)2.95638788
17Myotonia (HP:0002486)2.92874522
18Calf muscle hypertrophy (HP:0008981)2.92383056
19Neuroendocrine neoplasm (HP:0100634)2.87571848
20Muscle fiber splitting (HP:0003555)2.85262013
21Agitation (HP:0000713)2.81420069
22Prolonged QT interval (HP:0001657)2.81403653
23Vaginal atresia (HP:0000148)2.79841776
24Pancreatic fibrosis (HP:0100732)2.79676011
25Septo-optic dysplasia (HP:0100842)2.75198286
26Ankle clonus (HP:0011448)2.74935870
27Muscle hypertrophy of the lower extremities (HP:0008968)2.72879580
28Genital tract atresia (HP:0001827)2.71986829
29Focal motor seizures (HP:0011153)2.70955892
30Difficulty climbing stairs (HP:0003551)2.70563867
31Abnormality of the calf musculature (HP:0001430)2.70286066
32Myoglobinuria (HP:0002913)2.69671381
33Hyporeflexia of lower limbs (HP:0002600)2.69121298
34Atrial fibrillation (HP:0005110)2.67351985
35Type 1 muscle fiber predominance (HP:0003803)2.67053698
36Asymmetric septal hypertrophy (HP:0001670)2.65961220
37Primary atrial arrhythmia (HP:0001692)2.64919610
38Difficulty running (HP:0009046)2.64177593
39Amyotrophic lateral sclerosis (HP:0007354)2.62128875
40Syncope (HP:0001279)2.56711270
41Supraventricular arrhythmia (HP:0005115)2.55521905
42Increased variability in muscle fiber diameter (HP:0003557)2.53518721
43Supraventricular tachycardia (HP:0004755)2.51178072
44Supranuclear gaze palsy (HP:0000605)2.49729601
45Broad foot (HP:0001769)2.48765424
46Abnormal EKG (HP:0003115)2.48531252
47Broad metatarsal (HP:0001783)2.47558571
48Depression (HP:0000716)2.45659512
49Lissencephaly (HP:0001339)2.43321128
50Abnormality of the lower motor neuron (HP:0002366)2.41303326
51Rapidly progressive (HP:0003678)2.41178986
52Aplasia/Hypoplasia of the brainstem (HP:0007362)2.40448198
53Hypoplasia of the brainstem (HP:0002365)2.40448198
54Focal seizures (HP:0007359)2.39821327
55Hepatoblastoma (HP:0002884)2.38735555
56Specific learning disability (HP:0001328)2.37310693
57Sleep apnea (HP:0010535)2.36586936
58Hypercortisolism (HP:0001578)2.35161900
59Cerebral aneurysm (HP:0004944)2.34386467
60EMG: myopathic abnormalities (HP:0003458)2.34346446
61Palpitations (HP:0001962)2.32526715
62Colon cancer (HP:0003003)2.31854144
63Progressive cerebellar ataxia (HP:0002073)2.31227204
64Molar tooth sign on MRI (HP:0002419)2.30769500
65Abnormality of midbrain morphology (HP:0002418)2.30769500
66Ventricular arrhythmia (HP:0004308)2.28828884
67Action tremor (HP:0002345)2.28757420
68Anencephaly (HP:0002323)2.28475434
69Restlessness (HP:0000711)2.28050288
70True hermaphroditism (HP:0010459)2.26812882
71Abnormality of skeletal muscle fiber size (HP:0012084)2.26740112
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26592660
73Neoplasm of the peripheral nervous system (HP:0100007)2.25623302
74Heart block (HP:0012722)2.24745591
75Anxiety (HP:0000739)2.24683041
76Drooling (HP:0002307)2.23643135
77Muscle fiber inclusion bodies (HP:0100299)2.23587980
78Excessive salivation (HP:0003781)2.23574037
79Hypogonadotrophic hypogonadism (HP:0000044)2.22771680
80Acute necrotizing encephalopathy (HP:0006965)2.22362146
81Ventricular tachycardia (HP:0004756)2.19816757
82Broad distal phalanx of finger (HP:0009836)2.19708964
83Hypoventilation (HP:0002791)2.19508358
84Limb-girdle muscle atrophy (HP:0003797)2.15807793
85Atrioventricular block (HP:0001678)2.15737091
86Pancreatic cysts (HP:0001737)2.15464387
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14495364
88Anophthalmia (HP:0000528)2.11692573
89Esotropia (HP:0000565)2.11545127
90Long toe (HP:0010511)2.11139363
91Broad-based gait (HP:0002136)2.10570609
92Abnormality of the musculature of the pelvis (HP:0001469)2.10250176
93Abnormality of the hip-girdle musculature (HP:0001445)2.10250176
94Spastic gait (HP:0002064)2.09870614
95Gout (HP:0001997)2.08828596
96Abnormal atrioventricular conduction (HP:0005150)2.08804315
97Muscle stiffness (HP:0003552)2.08802853
98Anosmia (HP:0000458)2.08560425
99Amblyopia (HP:0000646)2.07158917
100Spastic tetraplegia (HP:0002510)2.06385400
101Insomnia (HP:0100785)2.06013062
102Poor coordination (HP:0002370)2.05344887
103Retinal dysplasia (HP:0007973)2.03303218
104Distal arthrogryposis (HP:0005684)2.02770997
105Turricephaly (HP:0000262)2.01511151
106Megalencephaly (HP:0001355)1.98793754
107Abnormal hair whorl (HP:0010721)1.98619102
108Atonic seizures (HP:0010819)1.97822388
109Abnormal mitochondria in muscle tissue (HP:0008316)1.97348202
110Stenosis of the external auditory canal (HP:0000402)1.97302026
111Mildly elevated creatine phosphokinase (HP:0008180)1.96521862
112Shoulder girdle muscle weakness (HP:0003547)1.96133766
113Lymphangioma (HP:0100764)1.95139312
114Torticollis (HP:0000473)1.94204967
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.92949594
116Abnormality of the vocal cords (HP:0008777)1.90613081
117Poor suck (HP:0002033)1.90036417
118Increased connective tissue (HP:0009025)1.88682165
119Abnormal respiratory motile cilium morphology (HP:0005938)1.88442988
120Abnormal respiratory epithelium morphology (HP:0012253)1.88442988
121Impaired pain sensation (HP:0007328)1.88437840
122Abnormality of pain sensation (HP:0010832)1.88437840
123Urinary bladder sphincter dysfunction (HP:0002839)1.88414763
124Maternal diabetes (HP:0009800)1.88272570
125Mutism (HP:0002300)1.87538777
126Polycythemia (HP:0001901)1.86926736
127Nemaline bodies (HP:0003798)1.86688857
128Abnormality of glycine metabolism (HP:0010895)1.85118947
129Abnormality of serine family amino acid metabolism (HP:0010894)1.85118947
130EMG: neuropathic changes (HP:0003445)1.84781245
131Oligomenorrhea (HP:0000876)1.84349751
132Nephronophthisis (HP:0000090)1.83922509
133Limb dystonia (HP:0002451)1.83774917
134Pachygyria (HP:0001302)1.83761126
135Inability to walk (HP:0002540)1.83599786
136Rib fusion (HP:0000902)1.83415975
137Neoplasm of the heart (HP:0100544)1.82999534
138Growth hormone excess (HP:0000845)1.80936736
139Vitreoretinal degeneration (HP:0000655)1.80865072
140Occipital encephalocele (HP:0002085)1.80093556
141Micropenis (HP:0000054)1.79569780
142Urinary urgency (HP:0000012)1.79447959
143Decreased muscle mass (HP:0003199)1.79123981
144Impaired vibration sensation in the lower limbs (HP:0002166)1.78556732
145Peripheral hypomyelination (HP:0007182)1.75354724
146Lipoatrophy (HP:0100578)1.74379805
147Myopathic facies (HP:0002058)1.73811687
148Annular pancreas (HP:0001734)1.73082077
149Hyperacusis (HP:0010780)1.72778361
150Abnormal eating behavior (HP:0100738)1.72686973
151Protrusio acetabuli (HP:0003179)1.72528414
152Focal dystonia (HP:0004373)1.71848245
153Humeroradial synostosis (HP:0003041)1.71681788
154Synostosis involving the elbow (HP:0003938)1.71681788
155Subaortic stenosis (HP:0001682)1.71511793
156Abnormality of the left ventricular outflow tract (HP:0011103)1.71511793
157Adrenal overactivity (HP:0002717)1.71047583
158Postural instability (HP:0002172)1.70735832
159Buphthalmos (HP:0000557)1.70263237
160Acute encephalopathy (HP:0006846)1.70164608
161Growth hormone deficiency (HP:0000824)1.70152126
162Sclerocornea (HP:0000647)1.70147343
163Ketoacidosis (HP:0001993)1.69704472
164Generalized hypotonia (HP:0001290)1.69621121
165Decreased testicular size (HP:0008734)1.69568698
166Anomalous pulmonary venous return (HP:0010772)1.69408800
167Left ventricular hypertrophy (HP:0001712)1.69062964
168Bladder diverticulum (HP:0000015)1.68899544
169Trigonocephaly (HP:0000243)1.68740972
170Generalized tonic-clonic seizures (HP:0002069)1.68738986
171Absence seizures (HP:0002121)1.68471972
172Aplasia/Hypoplasia of the lens (HP:0008063)1.68326756
173Split foot (HP:0001839)1.68140169
174Poor eye contact (HP:0000817)1.67253743
175Neoplasm of the adrenal gland (HP:0100631)1.67101142
176Rimmed vacuoles (HP:0003805)1.66339292
177Postaxial hand polydactyly (HP:0001162)1.65981041
178Enlarged penis (HP:0000040)1.65523528
179Central scotoma (HP:0000603)1.65305149
180Failure to thrive in infancy (HP:0001531)1.64364044
181Bronchomalacia (HP:0002780)1.64092046
182Right ventricular cardiomyopathy (HP:0011663)1.63876888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.23448442
2DYRK23.01907040
3KSR22.78106308
4BCKDK2.65496602
5TRIB32.64525687
6LMTK22.61078272
7PHKG12.55024889
8PHKG22.55024889
9DYRK32.49509694
10NTRK32.45839001
11PRKD32.40759972
12TIE12.29174469
13MINK12.16146810
14BCR2.16103083
15EPHA32.08501785
16LATS21.95911644
17EPHA41.92195726
18TESK21.92126783
19CSNK1G21.91283583
20PAK61.89316357
21DYRK1B1.86923058
22NEK11.85931674
23NTRK11.83383208
24PDK31.80916263
25PDK41.80916263
26ARAF1.80063596
27EPHB11.79703114
28TTN1.78658582
29CSNK1G31.78293937
30CASK1.74115540
31CSNK1A1L1.72448612
32MARK11.65662340
33PKN21.60176261
34RIPK11.58923987
35TRIM281.57841313
36PINK11.56422787
37MAP3K41.55462979
38WNK41.55348003
39DAPK21.54233918
40CAMKK21.52628841
41PAK31.52217854
42CAMKK11.49584440
43CSNK1G11.47435874
44KSR11.47176990
45MYLK1.45545592
46MAP3K121.44358238
47PDGFRA1.40586187
48LIMK11.29418337
49OBSCN1.26473901
50MAP2K41.26213367
51TAOK11.24898521
52ADRBK21.22099450
53DMPK1.21687707
54PTK2B1.21170238
55MAP3K21.18193236
56STK381.18054376
57FER1.16781897
58NTRK21.16206006
59MAP4K21.12761127
60RET1.11892946
61KDR1.05137581
62SRPK11.04923038
63TESK11.04269982
64TNK21.03030521
65WNK30.99002621
66MAPK130.97313338
67FGR0.95713508
68CDK50.92615259
69IRAK40.92385138
70MAP3K10.91650021
71MAPKAPK30.91134839
72MAP2K10.90920248
73SCYL20.90655168
74CAMK1G0.87275390
75DYRK1A0.86725761
76TYRO30.86251349
77MAP3K60.85978801
78STK160.82979763
79PDK20.81632958
80DDR20.81452532
81GRK70.81399496
82EPHB20.80239752
83UHMK10.79637983
84CAMK10.79457225
85MAP2K70.79064289
86ILK0.78799482
87SIK30.75141783
88GRK50.74397470
89DAPK10.73720288
90RAF10.71338576
91CDC42BPA0.67939908
92PRKCZ0.67580717
93CDK140.67239126
94VRK20.67150528
95PKN10.66984156
96PRKCH0.65611992
97MAP3K50.64321080
98PTK20.64280455
99TNIK0.63174382
100ROCK10.62580373
101MARK20.60351356
102ERN10.59995529
103STK110.59982819
104DAPK30.59623838
105PDPK10.58803017
106ADRBK10.58798976
107OXSR10.58763962
108CAMK1D0.57631104
109PRKCG0.57455638
110WNK10.57028204
111LRRK20.55586694
112RPS6KA40.54336054
113PRKD10.52921443
114SGK4940.51810350
115SGK2230.51810350
116CDK180.51352838
117BRAF0.51246667
118CDK150.50253102
119MAP3K110.50181595
120CAMK2A0.49432338
121FES0.48208780
122ICK0.47770442
123BMPR1B0.46665862
124ZAK0.46219573
125PRKD20.46042159
126PNCK0.45967405
127CAMK2D0.45141350
128CDK11A0.42929734
129CDK190.42890169
130GRK10.41713187
131PAK40.39310468
132ROCK20.38630911
133MAP3K70.38478596
134PDK10.38113363
135CAMK40.37453933
136PRKCE0.37387730
137RPS6KA20.37012138
138MAPK150.35910678
139PTK60.35877726
140SIK20.35421036
141BLK0.35095419
142NEK20.35040639
143CAMK2G0.34763624
144MAPK90.31138912
145CSK0.30558786
146PRKACA0.29759368
147MATK0.27604713
148INSRR0.26611795
149CSNK1A10.25528043
150FYN0.25341092
151GRK60.23403828

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.65327398
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55941720
3Synaptic vesicle cycle_Homo sapiens_hsa047212.51740361
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49167212
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35368871
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21031585
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17038447
8Olfactory transduction_Homo sapiens_hsa047402.16165924
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.15088271
10Cardiac muscle contraction_Homo sapiens_hsa042602.10577949
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.09596840
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99921135
13Insulin secretion_Homo sapiens_hsa049111.96720432
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.95129206
15Circadian entrainment_Homo sapiens_hsa047131.94824255
16Dilated cardiomyopathy_Homo sapiens_hsa054141.88010973
17Long-term potentiation_Homo sapiens_hsa047201.75921565
18GABAergic synapse_Homo sapiens_hsa047271.71926946
19Gastric acid secretion_Homo sapiens_hsa049711.68182678
20Dopaminergic synapse_Homo sapiens_hsa047281.63117015
21Amphetamine addiction_Homo sapiens_hsa050311.61831067
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61264391
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.55237572
24Oxytocin signaling pathway_Homo sapiens_hsa049211.54314296
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53891200
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47993979
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46113175
28Salivary secretion_Homo sapiens_hsa049701.45736870
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45720012
30Cholinergic synapse_Homo sapiens_hsa047251.44803090
31Morphine addiction_Homo sapiens_hsa050321.44658164
32Nicotine addiction_Homo sapiens_hsa050331.44610169
33Renin secretion_Homo sapiens_hsa049241.43435976
34Gap junction_Homo sapiens_hsa045401.43052338
35Regulation of autophagy_Homo sapiens_hsa041401.39689243
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39659564
37Glutamatergic synapse_Homo sapiens_hsa047241.34659307
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34555629
39GnRH signaling pathway_Homo sapiens_hsa049121.34490719
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32911480
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31405589
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31107142
43Phagosome_Homo sapiens_hsa041451.28261701
44Cocaine addiction_Homo sapiens_hsa050301.25224886
45Calcium signaling pathway_Homo sapiens_hsa040201.25159363
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24190198
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23860006
48Biosynthesis of amino acids_Homo sapiens_hsa012301.22203441
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22056725
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20534399
51Estrogen signaling pathway_Homo sapiens_hsa049151.20428624
52Taste transduction_Homo sapiens_hsa047421.18499538
53Steroid biosynthesis_Homo sapiens_hsa001001.15354696
54Vibrio cholerae infection_Homo sapiens_hsa051101.14459618
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.14166122
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13569757
57Glucagon signaling pathway_Homo sapiens_hsa049221.13107518
58Parkinsons disease_Homo sapiens_hsa050121.10060581
59cAMP signaling pathway_Homo sapiens_hsa040241.09141518
60Phototransduction_Homo sapiens_hsa047441.05545946
61Glioma_Homo sapiens_hsa052141.04658597
62Melanogenesis_Homo sapiens_hsa049161.04446219
63Arginine and proline metabolism_Homo sapiens_hsa003301.04193504
64Oocyte meiosis_Homo sapiens_hsa041141.01548588
65VEGF signaling pathway_Homo sapiens_hsa043701.00325165
66Collecting duct acid secretion_Homo sapiens_hsa049660.99896325
67Basal cell carcinoma_Homo sapiens_hsa052170.99167657
68Insulin signaling pathway_Homo sapiens_hsa049100.98411057
69Peroxisome_Homo sapiens_hsa041460.97618496
70Type II diabetes mellitus_Homo sapiens_hsa049300.92741030
71beta-Alanine metabolism_Homo sapiens_hsa004100.90692048
72Circadian rhythm_Homo sapiens_hsa047100.89002405
73Dorso-ventral axis formation_Homo sapiens_hsa043200.88798572
74Axon guidance_Homo sapiens_hsa043600.88386103
75Butanoate metabolism_Homo sapiens_hsa006500.88290934
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87987260
77Serotonergic synapse_Homo sapiens_hsa047260.87222775
78Long-term depression_Homo sapiens_hsa047300.87040717
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86962302
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85705586
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84035582
82Oxidative phosphorylation_Homo sapiens_hsa001900.83680236
83Alzheimers disease_Homo sapiens_hsa050100.83639893
84Thyroid hormone synthesis_Homo sapiens_hsa049180.83634669
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.82463751
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81336964
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80237689
88Focal adhesion_Homo sapiens_hsa045100.80024452
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79444774
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78474337
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.77483237
92Tight junction_Homo sapiens_hsa045300.77111931
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.75731930
94Fatty acid elongation_Homo sapiens_hsa000620.75611758
95Renal cell carcinoma_Homo sapiens_hsa052110.74922529
96Endocytosis_Homo sapiens_hsa041440.74255208
97Rap1 signaling pathway_Homo sapiens_hsa040150.71619604
98Pancreatic secretion_Homo sapiens_hsa049720.70732697
99Salmonella infection_Homo sapiens_hsa051320.70418443
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.70047113
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66920191
102Huntingtons disease_Homo sapiens_hsa050160.66582889
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66057328
104Notch signaling pathway_Homo sapiens_hsa043300.66022835
105Selenocompound metabolism_Homo sapiens_hsa004500.65368997
106Lysosome_Homo sapiens_hsa041420.64638966
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62525612
108mTOR signaling pathway_Homo sapiens_hsa041500.62069481
109Endometrial cancer_Homo sapiens_hsa052130.62004924
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61625739
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61465556
112ErbB signaling pathway_Homo sapiens_hsa040120.61412334
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59980493
114AMPK signaling pathway_Homo sapiens_hsa041520.58185158
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.58088861
116Carbon metabolism_Homo sapiens_hsa012000.57383458
117RNA polymerase_Homo sapiens_hsa030200.57353350
118Insulin resistance_Homo sapiens_hsa049310.56957356
119Prion diseases_Homo sapiens_hsa050200.56366191
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56120509
121Propanoate metabolism_Homo sapiens_hsa006400.55660175
122Hippo signaling pathway_Homo sapiens_hsa043900.55515966
123Choline metabolism in cancer_Homo sapiens_hsa052310.53223718
124Pyruvate metabolism_Homo sapiens_hsa006200.53206744
125Thyroid cancer_Homo sapiens_hsa052160.53001358
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52889912
127Sulfur relay system_Homo sapiens_hsa041220.52068145
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50957415
129Ether lipid metabolism_Homo sapiens_hsa005650.50710398
130Hedgehog signaling pathway_Homo sapiens_hsa043400.50622528
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50242819
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.50055941
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50022617
134MAPK signaling pathway_Homo sapiens_hsa040100.49967751
135Proteoglycans in cancer_Homo sapiens_hsa052050.48921479
136Bladder cancer_Homo sapiens_hsa052190.47608143
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47435469
138ECM-receptor interaction_Homo sapiens_hsa045120.46404697
139HIF-1 signaling pathway_Homo sapiens_hsa040660.46323745
140Wnt signaling pathway_Homo sapiens_hsa043100.46277577
141Ras signaling pathway_Homo sapiens_hsa040140.45914888
142Colorectal cancer_Homo sapiens_hsa052100.44339627
143Arachidonic acid metabolism_Homo sapiens_hsa005900.43465645
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41616324
145Metabolic pathways_Homo sapiens_hsa011000.40675151
146Galactose metabolism_Homo sapiens_hsa000520.39800706
147Tryptophan metabolism_Homo sapiens_hsa003800.34226467
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32796573
149Tuberculosis_Homo sapiens_hsa051520.30975170
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29180468
151Ribosome_Homo sapiens_hsa030100.27656342

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