OAZ3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.95024181
2axonemal dynein complex assembly (GO:0070286)9.85191571
3spermatid development (GO:0007286)9.76712168
4motile cilium assembly (GO:0044458)9.36165023
5reproduction (GO:0000003)9.10907497
6cilium or flagellum-dependent cell motility (GO:0001539)8.77055393
7regulation of cilium movement (GO:0003352)8.56755789
8cilium movement (GO:0003341)8.38683670
9sperm capacitation (GO:0048240)7.50649924
10single fertilization (GO:0007338)7.31466764
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.18036594
12microtubule depolymerization (GO:0007019)6.59670745
13negative regulation of inclusion body assembly (GO:0090084)6.58296403
14* spermatogenesis (GO:0007283)6.55946744
15* male gamete generation (GO:0048232)6.53627988
16synaptonemal complex organization (GO:0070193)6.39767250
17male meiosis (GO:0007140)6.33411535
18synaptonemal complex assembly (GO:0007130)6.24469907
19piRNA metabolic process (GO:0034587)6.16246779
20fertilization (GO:0009566)6.10640738
21* gamete generation (GO:0007276)6.01075288
22spermatid nucleus differentiation (GO:0007289)5.78121598
23response to pheromone (GO:0019236)5.66934911
24regulation of inclusion body assembly (GO:0090083)5.51257891
25calcium ion-dependent exocytosis (GO:0017156)5.45524636
26germ cell development (GO:0007281)5.37911976
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.28149058
28ventricular system development (GO:0021591)5.17414090
29behavioral response to nicotine (GO:0035095)5.08530096
30cell recognition (GO:0008037)4.93147670
31chromosome condensation (GO:0030261)4.85012104
32DNA packaging (GO:0006323)4.83788690
33male meiosis I (GO:0007141)4.83091866
34glycerol ether metabolic process (GO:0006662)4.80829442
35* organic cation transport (GO:0015695)4.76904825
36regulation of microtubule-based movement (GO:0060632)4.76547662
37* multicellular organismal reproductive process (GO:0048609)4.71202342
38single strand break repair (GO:0000012)4.69807178
39cellular ketone body metabolic process (GO:0046950)4.66453284
40chromosome organization involved in meiosis (GO:0070192)4.53406541
41microtubule severing (GO:0051013)4.47519968
42ether metabolic process (GO:0018904)4.47134030
43DNA methylation involved in gamete generation (GO:0043046)4.42905296
44seminiferous tubule development (GO:0072520)4.41673904
45sequestering of actin monomers (GO:0042989)4.36190453
46left/right pattern formation (GO:0060972)4.32989615
47sexual reproduction (GO:0019953)4.18746864
48ketone body metabolic process (GO:1902224)4.16984103
49phosphatidylethanolamine biosynthetic process (GO:0006646)4.05589143
50genitalia morphogenesis (GO:0035112)3.95749388
51meiotic nuclear division (GO:0007126)3.92121598
52multicellular organismal development (GO:0007275)3.92074244
53phosphatidylethanolamine metabolic process (GO:0046337)3.83867991
54protein localization to cilium (GO:0061512)3.79517096
55meiosis I (GO:0007127)3.75947111
56rRNA methylation (GO:0031167)3.73859600
57establishment of protein localization to Golgi (GO:0072600)3.71647047
58tryptophan catabolic process (GO:0006569)3.70779221
59indole-containing compound catabolic process (GO:0042436)3.70779221
60indolalkylamine catabolic process (GO:0046218)3.70779221
61protein K11-linked deubiquitination (GO:0035871)3.57977170
62protein polyglutamylation (GO:0018095)3.55990912
63sulfation (GO:0051923)3.53306927
64protein targeting to Golgi (GO:0000042)3.53009670
65microtubule polymerization or depolymerization (GO:0031109)3.39979122
66indolalkylamine metabolic process (GO:0006586)3.39778074
67GTP biosynthetic process (GO:0006183)3.39753306
68primary amino compound metabolic process (GO:1901160)3.38362705
69rRNA modification (GO:0000154)3.33430554
70detection of light stimulus involved in sensory perception (GO:0050962)3.31889814
71detection of light stimulus involved in visual perception (GO:0050908)3.31889814
72meiotic cell cycle (GO:0051321)3.31784583
73nucleoside diphosphate phosphorylation (GO:0006165)3.29166978
74RNA destabilization (GO:0050779)3.28630624
75RNA localization (GO:0006403)3.27363882
76protein refolding (GO:0042026)3.21865656
77nephron tubule morphogenesis (GO:0072078)3.20526414
78nephron epithelium morphogenesis (GO:0072088)3.20526414
79tryptophan metabolic process (GO:0006568)3.17865148
80protein localization to Golgi apparatus (GO:0034067)3.14707556
81amine catabolic process (GO:0009310)3.10527495
82cellular biogenic amine catabolic process (GO:0042402)3.10527495
83centriole assembly (GO:0098534)3.10513278
84chaperone-mediated protein complex assembly (GO:0051131)3.10207754
85cilium organization (GO:0044782)3.09447943
86retrograde transport, vesicle recycling within Golgi (GO:0000301)3.08341923
87L-fucose catabolic process (GO:0042355)3.06847347
88fucose catabolic process (GO:0019317)3.06847347
89L-fucose metabolic process (GO:0042354)3.06847347
90intraciliary transport (GO:0042073)3.04998799
91nucleus organization (GO:0006997)3.02988012
92cilium assembly (GO:0042384)3.01056549
93coenzyme catabolic process (GO:0009109)2.99203829
94negative regulation of telomere maintenance (GO:0032205)2.97716852
95neuronal action potential (GO:0019228)2.95852864
96mitochondrion degradation (GO:0000422)2.95662410
97synapsis (GO:0007129)2.95540334
98regulation of spindle checkpoint (GO:0090231)2.94770588
99positive regulation of macrophage activation (GO:0043032)2.93467050
100polyol catabolic process (GO:0046174)2.92889397
101interferon-gamma secretion (GO:0072643)2.91970371
102UTP biosynthetic process (GO:0006228)2.89018929
103axoneme assembly (GO:0035082)2.88254714
104indole-containing compound metabolic process (GO:0042430)2.84495141
105detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.83276292
106negative regulation of reactive oxygen species metabolic process (GO:2000378)2.82877301
107kynurenine metabolic process (GO:0070189)2.82074475
108peptidyl-threonine dephosphorylation (GO:0035970)2.79411728
109cellular component assembly involved in morphogenesis (GO:0010927)2.78336723
110regulation of action potential (GO:0098900)2.76850235
111DNA deamination (GO:0045006)2.76116224
112cilium morphogenesis (GO:0060271)2.75862668
113serotonin metabolic process (GO:0042428)2.71274978
114cytidine metabolic process (GO:0046087)2.70740807
115cytidine catabolic process (GO:0006216)2.70740807
116cytidine deamination (GO:0009972)2.70740807
117alanine transport (GO:0032328)2.66586922
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66418448
119nucleosome disassembly (GO:0006337)2.65162133
120protein-DNA complex disassembly (GO:0032986)2.65162133
121NAD biosynthetic process (GO:0009435)2.63073491
122regulation of cilium assembly (GO:1902017)2.61815412
123monoubiquitinated protein deubiquitination (GO:0035520)2.60356753
124alditol metabolic process (GO:0019400)2.58348173
125centriole replication (GO:0007099)2.58161522
126meiotic cell cycle process (GO:1903046)2.57605585
127membrane depolarization during action potential (GO:0086010)2.57424007
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53799660
129rhodopsin mediated signaling pathway (GO:0016056)2.53513566
130reflex (GO:0060004)2.52681091
131regulation of acrosome reaction (GO:0060046)2.52225576
132platelet dense granule organization (GO:0060155)2.51966430
133positive regulation of Rab GTPase activity (GO:0032851)2.51762532
134regulation of Rab GTPase activity (GO:0032313)2.51762532
135positive regulation of action potential (GO:0045760)2.51652606
136microtubule-based movement (GO:0007018)2.50781991
137UTP metabolic process (GO:0046051)2.50147961
138spinal cord motor neuron differentiation (GO:0021522)2.48826146
139glycolytic process (GO:0006096)2.41049751
140carnitine transport (GO:0015879)2.39474519
141amino-acid betaine transport (GO:0015838)2.39474519
142guanosine-containing compound biosynthetic process (GO:1901070)2.37956796
143sperm motility (GO:0030317)14.2873186
144cell wall macromolecule metabolic process (GO:0044036)13.3453951
145cell wall macromolecule catabolic process (GO:0016998)13.3453951
146fusion of sperm to egg plasma membrane (GO:0007342)13.0895330
147acrosome reaction (GO:0007340)12.3617411
148sperm-egg recognition (GO:0035036)11.4148856
149acrosome assembly (GO:0001675)10.8059192
150multicellular organism reproduction (GO:0032504)10.5152482
151binding of sperm to zona pellucida (GO:0007339)10.4821431
152epithelial cilium movement (GO:0003351)10.3835503
153cell-cell recognition (GO:0009988)10.1868811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.16308508
2EZH2_22144423_ChIP-Seq_EOC_Human4.94797639
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.72513390
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.86186835
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.92460626
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81993589
7GBX2_23144817_ChIP-Seq_PC3_Human2.57256960
8IGF1R_20145208_ChIP-Seq_DFB_Human2.44743748
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.44101722
10VDR_22108803_ChIP-Seq_LS180_Human2.42927436
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27759574
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20481466
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20087741
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15898176
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10958892
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.03357635
17ER_23166858_ChIP-Seq_MCF-7_Human2.01074958
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98219678
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94654927
20P300_19829295_ChIP-Seq_ESCs_Human1.82960448
21ZNF274_21170338_ChIP-Seq_K562_Hela1.82760743
22* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77084286
23STAT1_17558387_ChIP-Seq_HELA_Human1.75305016
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.66777360
25GATA3_21867929_ChIP-Seq_CD8_Mouse1.65757547
26TAL1_26923725_Chip-Seq_HPCs_Mouse1.63957774
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62800305
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62352850
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.62279736
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62133848
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61824453
32AR_25329375_ChIP-Seq_VCAP_Human1.61117094
33ERA_21632823_ChIP-Seq_H3396_Human1.60699045
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.60183796
35KDM2B_26808549_Chip-Seq_REH_Human1.57570787
36RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54537523
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.53873265
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52816740
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51396289
40AR_21572438_ChIP-Seq_LNCaP_Human1.51362370
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51071960
42* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50979245
43TAF15_26573619_Chip-Seq_HEK293_Human1.50896714
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50620056
45BCAT_22108803_ChIP-Seq_LS180_Human1.49204403
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46809065
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.45967683
48TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.45959259
49NANOG_19829295_ChIP-Seq_ESCs_Human1.45917766
50SOX2_19829295_ChIP-Seq_ESCs_Human1.45917766
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.44981279
52SMAD4_21799915_ChIP-Seq_A2780_Human1.43619016
53CBP_20019798_ChIP-Seq_JUKART_Human1.42949592
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42949592
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42667816
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42418393
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.40850503
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37468140
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37461549
60MYC_19829295_ChIP-Seq_ESCs_Human1.37187378
61STAT3_23295773_ChIP-Seq_U87_Human1.37161158
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35916938
63FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32898623
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.32693064
65RUNX2_22187159_ChIP-Seq_PCA_Human1.31865937
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.31538255
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30401360
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29807802
69GATA3_21867929_ChIP-Seq_TH1_Mouse1.28995657
70IRF1_19129219_ChIP-ChIP_H3396_Human1.28919070
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.28893123
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28713609
73P53_21459846_ChIP-Seq_SAOS-2_Human1.28409239
74P53_22387025_ChIP-Seq_ESCs_Mouse1.27889074
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27574566
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.27410259
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27410259
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27391857
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.26889171
80TP53_22573176_ChIP-Seq_HFKS_Human1.26811073
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26772618
82OCT4_20526341_ChIP-Seq_ESCs_Human1.26357543
83HOXB7_26014856_ChIP-Seq_BT474_Human1.26165606
84GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.25541964
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25287651
86RAC3_21632823_ChIP-Seq_H3396_Human1.24926748
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23616792
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.23328838
89TCF4_23295773_ChIP-Seq_U87_Human1.22282676
90REST_21632747_ChIP-Seq_MESCs_Mouse1.20883487
91EWS_26573619_Chip-Seq_HEK293_Human1.20508153
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20276851
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20083371
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19986096
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.19944838
96P300_18555785_Chip-Seq_ESCs_Mouse1.19150262
97TAF2_19829295_ChIP-Seq_ESCs_Human1.19008573
98NCOR_22424771_ChIP-Seq_293T_Human1.18750293
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.17437605
100GF1_26923725_Chip-Seq_HPCs_Mouse1.17072839
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.16674388
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16284807
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.14950980
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14614145
105RNF2_27304074_Chip-Seq_NSC_Mouse1.14594319
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.14218700
107SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14087168
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13763247
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13755293
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.13688500
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12820064
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12665473
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12647441
114* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12577139
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12388476
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.12142810
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12051686
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12051686
119TCF4_22108803_ChIP-Seq_LS180_Human1.11878205
120* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11309047
121* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10958401
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10836137
123EZH2_27294783_Chip-Seq_ESCs_Mouse1.10366024
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09531078
125* ERG_20517297_ChIP-Seq_VCAP_Human1.08905803
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.08785275
127ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08081320
128FOXH1_21741376_ChIP-Seq_EPCs_Human1.07573437
129OCT1_27270436_Chip-Seq_PROSTATE_Human1.07562041
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07111305
131AR_20517297_ChIP-Seq_VCAP_Human1.06606476
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.06152819
133* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05894025
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05217416
135PU1_27457419_Chip-Seq_LIVER_Mouse1.04778561
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.04681343
137DROSHA_22980978_ChIP-Seq_HELA_Human1.03900320
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03801068
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03682908
140TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03547001
141SOX2_18555785_Chip-Seq_ESCs_Mouse1.03141962
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02852661
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02559408
144LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02547687
145LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.02417425
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.02382949
147* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02143160
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01917375
149FOXH1_21741376_ChIP-Seq_ESCs_Human1.01618517
150TBL1_22424771_ChIP-Seq_293T_Human1.01529339
151* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01122219
152NMYC_18555785_Chip-Seq_ESCs_Mouse1.00324997
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99993646
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99648771
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99598216
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98837506
157SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98669549
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98578850
159PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98519824
160ETV1_20927104_ChIP-Seq_GIST48_Human0.98378613
161NFYB_21822215_ChIP-Seq_K562_Human0.98331352
162FUS_26573619_Chip-Seq_HEK293_Human0.97971038
163PHF8_20622853_ChIP-Seq_HELA_Human0.97964129
164E2F1_18555785_Chip-Seq_ESCs_Mouse0.97414305
165AHR_22903824_ChIP-Seq_MCF-7_Human0.97278341
166HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97160047
167* ESET_19884257_ChIP-Seq_ESCs_Mouse0.96684967
168PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96390300
169SPI1_26923725_Chip-Seq_HPCs_Mouse0.96296176
170RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96261664
171ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95207131
172CTCF_18555785_Chip-Seq_ESCs_Mouse0.94495659
173NANOG_20526341_ChIP-Seq_ESCs_Human0.93593712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.79836667
2* MP0001929_abnormal_gametogenesis5.17544552
3MP0008877_abnormal_DNA_methylation3.30899103
4MP0002210_abnormal_sex_determination3.30837106
5* MP0002161_abnormal_fertility/fecundity3.05140735
6MP0001145_abnormal_male_reproductive2.75712299
7MP0005670_abnormal_white_adipose2.46270579
8MP0000653_abnormal_sex_gland2.37556591
9MP0003646_muscle_fatigue2.29176251
10MP0003195_calcinosis2.15258293
11* MP0005410_abnormal_fertilization15.3895957
12MP0001485_abnormal_pinna_reflex1.88967159
13MP0002160_abnormal_reproductive_system1.82913931
14MP0008872_abnormal_physiological_respon1.81476204
15MP0005645_abnormal_hypothalamus_physiol1.77154119
16MP0009745_abnormal_behavioral_response1.75091705
17MP0003718_maternal_effect1.74836318
18MP0001905_abnormal_dopamine_level1.73229088
19MP0005646_abnormal_pituitary_gland1.66400452
20MP0002735_abnormal_chemical_nociception1.65061124
21MP0002837_dystrophic_cardiac_calcinosis1.63520076
22MP0002653_abnormal_ependyma_morphology1.55763729
23MP0006072_abnormal_retinal_apoptosis1.55633422
24MP0002138_abnormal_hepatobiliary_system1.54002162
25MP0010386_abnormal_urinary_bladder1.53098029
26MP0002638_abnormal_pupillary_reflex1.50291621
27MP0001501_abnormal_sleep_pattern1.46227991
28MP0005174_abnormal_tail_pigmentation1.41629001
29MP0005084_abnormal_gallbladder_morpholo1.38072255
30MP0008875_abnormal_xenobiotic_pharmacok1.31809503
31MP0005167_abnormal_blood-brain_barrier1.29468614
32MP0004142_abnormal_muscle_tone1.27672168
33MP0002572_abnormal_emotion/affect_behav1.23605196
34MP0002067_abnormal_sensory_capabilities1.23198289
35MP0008995_early_reproductive_senescence1.23111738
36MP0002733_abnormal_thermal_nociception1.20533779
37MP0006276_abnormal_autonomic_nervous1.20236347
38MP0004885_abnormal_endolymph1.19882148
39MP0008058_abnormal_DNA_repair1.19834377
40MP0002557_abnormal_social/conspecific_i1.19176882
41MP0002064_seizures1.16045210
42MP0001970_abnormal_pain_threshold1.14034624
43MP0001984_abnormal_olfaction1.14003436
44MP0001986_abnormal_taste_sensitivity1.12017290
45MP0000230_abnormal_systemic_arterial1.11927285
46MP0002102_abnormal_ear_morphology1.09383857
47MP0003136_yellow_coat_color1.09332731
48MP0000015_abnormal_ear_pigmentation1.07727926
49MP0005409_darkened_coat_color1.07144452
50MP0002282_abnormal_trachea_morphology1.05532097
51MP0000569_abnormal_digit_pigmentation1.04809076
52MP0001765_abnormal_ion_homeostasis1.02745498
53MP0004043_abnormal_pH_regulation1.00704767
54MP0002277_abnormal_respiratory_mucosa0.98960039
55MP0003315_abnormal_perineum_morphology0.98395503
56MP0005360_urolithiasis0.96844339
57MP0005075_abnormal_melanosome_morpholog0.96456908
58MP0005389_reproductive_system_phenotype0.94934784
59MP0000427_abnormal_hair_cycle0.93433880
60MP0001188_hyperpigmentation0.91629028
61MP0004085_abnormal_heartbeat0.90907919
62MP0004147_increased_porphyrin_level0.90793562
63MP0003879_abnormal_hair_cell0.88443175
64MP0003635_abnormal_synaptic_transmissio0.87077261
65MP0005647_abnormal_sex_gland0.86941392
66MP0006292_abnormal_olfactory_placode0.83951895
67MP0004381_abnormal_hair_follicle0.83766496
68MP0005386_behavior/neurological_phenoty0.83310488
69MP0004924_abnormal_behavior0.83310488
70MP0000538_abnormal_urinary_bladder0.82857326
71MP0005395_other_phenotype0.82784438
72MP0002063_abnormal_learning/memory/cond0.82499723
73MP0003878_abnormal_ear_physiology0.80846954
74MP0005377_hearing/vestibular/ear_phenot0.80846954
75MP0009379_abnormal_foot_pigmentation0.80709562
76MP0003787_abnormal_imprinting0.79925640
77MP0005623_abnormal_meninges_morphology0.78486303
78MP0005195_abnormal_posterior_eye0.77997633
79MP0003011_delayed_dark_adaptation0.77443065
80MP0001664_abnormal_digestion0.77105177
81MP0002234_abnormal_pharynx_morphology0.77018984
82MP0004215_abnormal_myocardial_fiber0.76501400
83MP0008775_abnormal_heart_ventricle0.76496510
84MP0003045_fibrosis0.76486953
85MP0005332_abnormal_amino_acid0.76323324
86MP0001529_abnormal_vocalization0.76221799
87MP0009046_muscle_twitch0.75230765
88MP0001324_abnormal_eye_pigmentation0.72583626
89MP0005397_hematopoietic_system_phenotyp0.71469959
90MP0001545_abnormal_hematopoietic_system0.71469959
91MP0005636_abnormal_mineral_homeostasis0.70789630
92MP0000372_irregular_coat_pigmentation0.68578572
93MP0002132_abnormal_respiratory_system0.68051096
94MP0003880_abnormal_central_pattern0.66495057
95MP0002736_abnormal_nociception_after0.65449292
96MP0009785_altered_susceptibility_to0.62318573
97MP0003786_premature_aging0.59234419
98MP0002095_abnormal_skin_pigmentation0.58742367
99MP0004742_abnormal_vestibular_system0.57804582
100MP0003724_increased_susceptibility_to0.56736811
101MP0001968_abnormal_touch/_nociception0.56420369
102MP0005551_abnormal_eye_electrophysiolog0.56402749
103MP0001835_abnormal_antigen_presentation0.54396953
104MP0004233_abnormal_muscle_weight0.53733092
105MP0000049_abnormal_middle_ear0.49737845
106MP0010094_abnormal_chromosome_stability0.48506593
107MP0001764_abnormal_homeostasis0.48114635
108MP0002876_abnormal_thyroid_physiology0.47949990
109MP0005423_abnormal_somatic_nervous0.46310660
110MP0006036_abnormal_mitochondrial_physio0.46152520
111MP0009697_abnormal_copulation0.45267172
112MP0000566_synostosis0.44044720
113MP0005671_abnormal_response_to0.43868096
114MP0005253_abnormal_eye_physiology0.43799071
115MP0001119_abnormal_female_reproductive0.42402492
116MP0000631_abnormal_neuroendocrine_gland0.42345878
117MP0003699_abnormal_female_reproductive0.42055233
118MP0009278_abnormal_bone_marrow0.42036764
119MP0002405_respiratory_system_inflammati0.41983640
120MP0008007_abnormal_cellular_replicative0.41810204
121MP0002148_abnormal_hypersensitivity_rea0.40527250
122MP0002177_abnormal_outer_ear0.40065591
123MP0001293_anophthalmia0.39884465
124MP0002009_preneoplasia0.39651238
125MP0000685_abnormal_immune_system0.38816167
126MP0001963_abnormal_hearing_physiology0.38699044
127MP0003938_abnormal_ear_development0.38458504
128MP0000026_abnormal_inner_ear0.38112436
129MP0005025_abnormal_response_to0.37444328
130MP0005379_endocrine/exocrine_gland_phen0.36264807
131MP0008569_lethality_at_weaning0.36262833
132MP0002163_abnormal_gland_morphology0.35538558
133MP0001919_abnormal_reproductive_system0.35435301
134MP0002693_abnormal_pancreas_physiology0.35301965
135MP0004808_abnormal_hematopoietic_stem0.34908223
136MP0003115_abnormal_respiratory_system0.33403369
137MP0002272_abnormal_nervous_system0.32572014
138MP0002723_abnormal_immune_serum0.32394445
139MP0004145_abnormal_muscle_electrophysio0.31803940
140MP0003959_abnormal_lean_body0.31356698
141MP0001486_abnormal_startle_reflex0.29020336
142MP0002752_abnormal_somatic_nervous0.28942281
143MP0002928_abnormal_bile_duct0.28931370
144MP0001348_abnormal_lacrimal_gland0.28903758
145MP0003868_abnormal_feces_composition0.28879649
146MP0005391_vision/eye_phenotype0.28598538
147MP0001873_stomach_inflammation0.28219109
148MP0000358_abnormal_cell_content/0.26027599
149MP0002229_neurodegeneration0.25479700
150MP0004133_heterotaxia0.24974834

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.91543252
2Abnormal respiratory motile cilium morphology (HP:0005938)8.91543252
3Abnormal respiratory motile cilium physiology (HP:0012261)8.70073338
4Abnormal ciliary motility (HP:0012262)7.04482740
5Rhinitis (HP:0012384)6.89285646
6Chronic bronchitis (HP:0004469)6.59443088
7Infertility (HP:0000789)6.45261216
8Nasal polyposis (HP:0100582)6.22928890
9Abnormality of the nasal mucosa (HP:0000433)5.12640726
10Bronchitis (HP:0012387)4.37837083
11Bronchiectasis (HP:0002110)4.27566280
12Nephronophthisis (HP:0000090)4.27413971
13Type II lissencephaly (HP:0007260)4.11067256
14Male infertility (HP:0003251)3.92566080
15Abnormal spermatogenesis (HP:0008669)3.79486049
16Congenital stationary night blindness (HP:0007642)3.61708059
17Abnormal rod and cone electroretinograms (HP:0008323)3.47471522
18Abnormality of the renal medulla (HP:0100957)3.29079602
19Recurrent sinusitis (HP:0011108)3.26816882
20Tubulointerstitial nephritis (HP:0001970)3.22116694
21Cerebellar dysplasia (HP:0007033)3.18505893
22Bony spicule pigmentary retinopathy (HP:0007737)3.14169622
23Recurrent otitis media (HP:0000403)3.03635142
24Recurrent bronchitis (HP:0002837)2.90099746
25Polyuria (HP:0000103)2.89020191
26Inability to walk (HP:0002540)2.72104444
27Hypoplasia of the uterus (HP:0000013)2.70190720
28Molar tooth sign on MRI (HP:0002419)2.66732478
29Abnormality of midbrain morphology (HP:0002418)2.66732478
30Progressive cerebellar ataxia (HP:0002073)2.62941323
31Azoospermia (HP:0000027)2.60469543
32Medial flaring of the eyebrow (HP:0010747)2.60332051
33Abnormal urine output (HP:0012590)2.60017138
34Aplasia/hypoplasia of the uterus (HP:0008684)2.57413621
35Decreased central vision (HP:0007663)2.50915286
36Dyschromatopsia (HP:0007641)2.50835518
37Pendular nystagmus (HP:0012043)2.50018081
38Impulsivity (HP:0100710)2.46486120
39Abnormality of macular pigmentation (HP:0008002)2.42611666
40Congenital sensorineural hearing impairment (HP:0008527)2.40733183
41Gonadotropin excess (HP:0000837)2.40529554
42Increased corneal curvature (HP:0100692)2.34229847
43Keratoconus (HP:0000563)2.34229847
44Sclerocornea (HP:0000647)2.33427879
45Gaze-evoked nystagmus (HP:0000640)2.32418259
46Tubulointerstitial abnormality (HP:0001969)2.30552032
47Hyperventilation (HP:0002883)2.30086933
48Large for gestational age (HP:0001520)2.27516565
49Hypothermia (HP:0002045)2.26051202
50Abnormality of alanine metabolism (HP:0010916)2.25716473
51Hyperalaninemia (HP:0003348)2.25716473
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25716473
53Abolished electroretinogram (ERG) (HP:0000550)2.22247679
54Tubular atrophy (HP:0000092)2.21488793
55Concave nail (HP:0001598)2.21220945
56Occipital encephalocele (HP:0002085)2.19702272
57Bile duct proliferation (HP:0001408)2.14702889
58Abnormal biliary tract physiology (HP:0012439)2.14702889
59Type 2 muscle fiber atrophy (HP:0003554)2.12512586
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11004993
61Postaxial foot polydactyly (HP:0001830)2.09687022
62Amelogenesis imperfecta (HP:0000705)2.09015463
63Nonprogressive disorder (HP:0003680)2.08576317
64True hermaphroditism (HP:0010459)2.07840425
65Lissencephaly (HP:0001339)2.02829503
66Absent/shortened dynein arms (HP:0200106)12.6522412
67Dynein arm defect of respiratory motile cilia (HP:0012255)12.6522412
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0431226
69Facial shape deformation (HP:0011334)1.97147494
70Potter facies (HP:0002009)1.97147494
71Chorioretinal atrophy (HP:0000533)1.95210124
72Furrowed tongue (HP:0000221)1.94155143
73Congenital hepatic fibrosis (HP:0002612)1.92961513
74Pancreatic fibrosis (HP:0100732)1.92888660
75Decreased circulating renin level (HP:0003351)1.91723574
76Anterior segment dysgenesis (HP:0007700)1.91309749
77Absent speech (HP:0001344)1.91242061
78Stage 5 chronic kidney disease (HP:0003774)1.89970204
79Protruding tongue (HP:0010808)1.85466173
80Bulbous nose (HP:0000414)1.83333106
81Congenital, generalized hypertrichosis (HP:0004540)1.82953409
82Hyperkalemia (HP:0002153)1.82700520
83Renal cortical cysts (HP:0000803)1.81741413
84Genetic anticipation (HP:0003743)1.80882012
85Attenuation of retinal blood vessels (HP:0007843)1.80286094
86Abnormal gallbladder physiology (HP:0012438)1.79951805
87Cholecystitis (HP:0001082)1.79951805
88Muscle fiber atrophy (HP:0100295)1.77466985
89Photophobia (HP:0000613)1.76633031
90Abnormality of dental color (HP:0011073)1.75881352
91Genital tract atresia (HP:0001827)1.75450577
92Hypoalbuminemia (HP:0003073)1.75333793
93Abnormal albumin level (HP:0012116)1.75333793
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74583691
95Abnormality of the pons (HP:0007361)1.73535205
96Progressive inability to walk (HP:0002505)1.72419189
97Absent thumb (HP:0009777)1.70456477
98Abnormality of permanent molar morphology (HP:0011071)1.70386746
99Abnormality of the dental root (HP:0006486)1.70386746
100Taurodontia (HP:0000679)1.70386746
101Vaginal atresia (HP:0000148)1.69862976
102Abnormal drinking behavior (HP:0030082)1.69383990
103Polydipsia (HP:0001959)1.69383990
104Hypoplastic ischia (HP:0003175)1.69092431
105Aplasia/Hypoplasia of the lens (HP:0008063)1.67860724
106Choroideremia (HP:0001139)1.66322274
107Abnormality of the neuromuscular junction (HP:0003398)1.65518901
108Fatigable weakness (HP:0003473)1.65518901
109Abnormality of molar morphology (HP:0011070)1.65402102
110Abnormality of molar (HP:0011077)1.65402102
111Renal dysplasia (HP:0000110)1.64184578
112Retrobulbar optic neuritis (HP:0100654)1.63947524
113Optic neuritis (HP:0100653)1.63947524
114Abnormality of the renal cortex (HP:0011035)1.62948613
115Reduced antithrombin III activity (HP:0001976)1.59408693
116Congenital malformation of the right heart (HP:0011723)1.59364070
117Double outlet right ventricle (HP:0001719)1.59364070
118Abnormality of the dental pulp (HP:0006479)1.57839511
119Easy fatigability (HP:0003388)1.56151490
120Pancreatic cysts (HP:0001737)1.55483407
121Abnormality of renal excretion (HP:0011036)1.55317831
122Cystic liver disease (HP:0006706)1.53141958
123Postaxial hand polydactyly (HP:0001162)1.51274821
124Severe visual impairment (HP:0001141)1.49402363
125Chronic sinusitis (HP:0011109)1.48553202
126Tubulointerstitial fibrosis (HP:0005576)1.48182840
127Optic nerve hypoplasia (HP:0000609)1.47934572
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.47529622
129Oculomotor apraxia (HP:0000657)1.46912706
130Constricted visual fields (HP:0001133)1.45846661
131Supernumerary spleens (HP:0009799)1.45121182
132Retinal dysplasia (HP:0007973)1.41459350
133Type I transferrin isoform profile (HP:0003642)1.41443757
134Decreased electroretinogram (ERG) amplitude (HP:0000654)1.40252458
135Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.38261211
136Congenital primary aphakia (HP:0007707)1.37440428
137Weak cry (HP:0001612)1.36772106
138Sensory axonal neuropathy (HP:0003390)1.35149762
139Spastic tetraparesis (HP:0001285)1.34327397
140Abnormality of renal resorption (HP:0011038)1.34038373
141Gait imbalance (HP:0002141)1.33975461
142Nephropathy (HP:0000112)1.33673942
143Optic disc pallor (HP:0000543)1.32909287
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.30989834
145Male pseudohermaphroditism (HP:0000037)1.30454462
146Abnormal number of erythroid precursors (HP:0012131)1.29692403
147Anencephaly (HP:0002323)1.29048385
148Median cleft lip (HP:0000161)1.28864497
149Fibular hypoplasia (HP:0003038)1.28551484
150Nephrogenic diabetes insipidus (HP:0009806)1.27845157
151Orchitis (HP:0100796)1.27017791
152Thyroid-stimulating hormone excess (HP:0002925)1.25885448
153Chronic hepatic failure (HP:0100626)1.25717334
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.25712163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.45048746
2PDK47.45048746
3TESK16.10501883
4PDK24.85594428
5FRK4.53744133
6PRKD34.16524422
7ZAK4.13669778
8ICK3.93822294
9TNIK2.98126321
10MAP4K22.92246437
11INSRR2.53751359
12MUSK2.51901989
13STK38L1.92915989
14STK391.85740340
15PTK2B1.81140297
16MARK31.73932765
17ACVR1B1.71037243
18WNK41.70970137
19DYRK1B1.65638565
20WNK31.65375832
21STK161.63948610
22NUAK11.63225457
23STK381.52764463
24DAPK21.50142771
25RPS6KA51.46555015
26TAOK31.45960913
27IRAK11.34867595
28PNCK1.34205948
29MAP3K41.32965196
30DYRK31.20888658
31NEK21.14062520
32PLK21.09529770
33MAPK151.08051117
34IRAK21.06133819
35OXSR11.05706269
36RIPK41.01556481
37PDK11.01102984
38CASK1.00434251
39MAP2K60.91447491
40MKNK20.90287177
41TRIM280.84351447
42CCNB10.79310958
43PAK30.78439601
44FGFR20.76487475
45ADRBK10.75098021
46NLK0.72607783
47CSNK1G30.71416388
48PRKCE0.70413124
49PINK10.68932332
50CSNK1G20.67617696
51IKBKB0.67365764
52DDR20.66582317
53CSNK1G10.66458519
54MAPKAPK50.66140660
55PIK3CA0.64831871
56PIK3CG0.62888626
57CSNK1A1L0.62867043
58YES10.62827730
59MAPKAPK30.62377724
60DYRK20.62293742
61TGFBR10.62095806
62SIK20.61868273
63PASK0.61793873
64MAP2K70.61555138
65NTRK30.61125487
66CLK10.60924456
67SRPK10.60692965
68LATS10.55427813
69PKN10.53927396
70TLK10.53792987
71PRKAA20.53585724
72OBSCN0.51954200
73KIT0.51819793
74PDPK10.51716891
75TXK0.51529094
76PLK40.50875021
77NEK60.49858729
78CHEK20.48034935
79WEE10.47649320
80MKNK10.47366615
81FES0.46062111
82ADRBK20.45823650
83NME20.45727812
84TEC0.45531284
85WNK10.45449983
86CAMK10.44877172
87CAMK1D0.44823235
88BCKDK0.43513041
89AKT30.42982107
90PRKG20.42525397
91EIF2AK30.39078112
92MAP2K20.38927381
93SGK2230.38237912
94SGK4940.38237912
95PRKACA0.36720704
96PAK10.35994545
97ITK0.35910666
98CAMK40.35879812
99CDK190.35500999
100PIM20.35366528
101MARK10.34961627
102TTK0.33857549
103PHKG20.33693372
104PHKG10.33693372
105CSNK1A10.33491807
106IRAK40.32921586
107CDK30.32737181
108BMPR1B0.30302577
109PRKCZ0.30112756
110RPS6KA60.29839820
111PRKCG0.28844654
112GRK10.28301698
113PRKCI0.28116870
114ROCK10.27628214
115PRKCA0.27485788
116MST40.26416278
117BTK0.25833505
118EIF2AK20.25092535
119ATR0.24674631
120RPS6KB10.24595602
121MAPK40.23117710
122PIM10.22960751
123CSF1R0.22771086
124MARK20.22603788
125MAP4K10.21686203
126ATM0.21515963
127TESK20.21313946
128TIE10.20343175
129NTRK20.19859117
130STK30.19450044
131VRK10.19358758
132CSNK2A10.19008500
133GRK70.17916636
134PAK20.17095922
135CAMKK20.16603890
136MYLK0.15669971
137BRSK20.15567616
138PRKCQ0.14773666
139ZAP700.14004378
140MAPK130.13311330
141LYN0.12805674
142PRKD20.12786292
143CHEK10.12304283
144PRKG10.12024023
145CAMK1G0.10944053
146CSNK2A20.10772922
147LCK0.10691609
148TYRO30.10549062
149CAMK2A0.10061909
150PRKAA10.09143875
151BRAF0.08518405
152PRKCD0.08443739
153BLK0.07640794
154LMTK20.07511840
155TNK20.07381273
156SYK0.06254600

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.72465907
2Nitrogen metabolism_Homo sapiens_hsa009103.44700106
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.42467348
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.25587240
5Linoleic acid metabolism_Homo sapiens_hsa005913.25484736
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23453319
7Basal transcription factors_Homo sapiens_hsa030222.99330098
8Butanoate metabolism_Homo sapiens_hsa006502.81750047
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.65787901
10Olfactory transduction_Homo sapiens_hsa047402.57501296
11Fanconi anemia pathway_Homo sapiens_hsa034602.42311228
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27756467
13Vitamin B6 metabolism_Homo sapiens_hsa007502.25659479
14Pyruvate metabolism_Homo sapiens_hsa006202.14251950
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09634176
16Ether lipid metabolism_Homo sapiens_hsa005652.09035142
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.99841609
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.97303148
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96945698
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83960513
21Glucagon signaling pathway_Homo sapiens_hsa049221.78898855
22Purine metabolism_Homo sapiens_hsa002301.76745247
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73635778
24Nicotine addiction_Homo sapiens_hsa050331.66608990
25Arachidonic acid metabolism_Homo sapiens_hsa005901.66256018
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63674454
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.61921289
28Huntingtons disease_Homo sapiens_hsa050161.60306681
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.58212357
30DNA replication_Homo sapiens_hsa030301.55434851
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.54945481
32Glycerolipid metabolism_Homo sapiens_hsa005611.54133504
33Tryptophan metabolism_Homo sapiens_hsa003801.52410687
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52164437
35Mineral absorption_Homo sapiens_hsa049781.41121031
36Pyrimidine metabolism_Homo sapiens_hsa002401.37616416
37Cardiac muscle contraction_Homo sapiens_hsa042601.35298565
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34826724
39Morphine addiction_Homo sapiens_hsa050321.31400609
40Propanoate metabolism_Homo sapiens_hsa006401.28445701
41Antigen processing and presentation_Homo sapiens_hsa046121.24687957
42Caffeine metabolism_Homo sapiens_hsa002321.24492621
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.23612376
44Fructose and mannose metabolism_Homo sapiens_hsa000511.20064242
45Amphetamine addiction_Homo sapiens_hsa050311.19212683
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16416325
47Selenocompound metabolism_Homo sapiens_hsa004501.15721073
48Peroxisome_Homo sapiens_hsa041461.14107235
49Homologous recombination_Homo sapiens_hsa034401.09425531
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09383954
51Oocyte meiosis_Homo sapiens_hsa041141.06028556
52Glutathione metabolism_Homo sapiens_hsa004801.05153423
53PPAR signaling pathway_Homo sapiens_hsa033200.99550919
54Systemic lupus erythematosus_Homo sapiens_hsa053220.99145832
55RNA polymerase_Homo sapiens_hsa030200.97327332
56Type I diabetes mellitus_Homo sapiens_hsa049400.97103295
57Serotonergic synapse_Homo sapiens_hsa047260.96461589
58Pentose phosphate pathway_Homo sapiens_hsa000300.95833734
59Retinol metabolism_Homo sapiens_hsa008300.95215068
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94049428
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.91464369
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91201762
63Sphingolipid metabolism_Homo sapiens_hsa006000.91164762
64mRNA surveillance pathway_Homo sapiens_hsa030150.89717543
65Other glycan degradation_Homo sapiens_hsa005110.89320517
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89251828
67Graft-versus-host disease_Homo sapiens_hsa053320.89040846
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88245786
69Regulation of autophagy_Homo sapiens_hsa041400.86271340
70GABAergic synapse_Homo sapiens_hsa047270.85514480
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84803602
72Glutamatergic synapse_Homo sapiens_hsa047240.83498739
73Fat digestion and absorption_Homo sapiens_hsa049750.83497989
74Hedgehog signaling pathway_Homo sapiens_hsa043400.83041207
75Protein export_Homo sapiens_hsa030600.81960215
76N-Glycan biosynthesis_Homo sapiens_hsa005100.81696225
77Renin secretion_Homo sapiens_hsa049240.80935861
78ABC transporters_Homo sapiens_hsa020100.80571527
79Autoimmune thyroid disease_Homo sapiens_hsa053200.78733785
80Collecting duct acid secretion_Homo sapiens_hsa049660.78723176
81Base excision repair_Homo sapiens_hsa034100.76534908
82Taste transduction_Homo sapiens_hsa047420.76008489
83Allograft rejection_Homo sapiens_hsa053300.75589632
84Oxidative phosphorylation_Homo sapiens_hsa001900.74902758
85Ovarian steroidogenesis_Homo sapiens_hsa049130.74825835
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74080154
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72721383
88Measles_Homo sapiens_hsa051620.71618235
89Dorso-ventral axis formation_Homo sapiens_hsa043200.71468111
90Non-homologous end-joining_Homo sapiens_hsa034500.70699629
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70513976
92Calcium signaling pathway_Homo sapiens_hsa040200.69911438
93Chemical carcinogenesis_Homo sapiens_hsa052040.68952755
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68290823
95RNA transport_Homo sapiens_hsa030130.67126051
96Ribosome_Homo sapiens_hsa030100.64345521
97Metabolic pathways_Homo sapiens_hsa011000.63613198
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61282529
99beta-Alanine metabolism_Homo sapiens_hsa004100.60032381
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59887715
101Alcoholism_Homo sapiens_hsa050340.58897121
102Legionellosis_Homo sapiens_hsa051340.58318830
103Insulin secretion_Homo sapiens_hsa049110.56431673
104Phototransduction_Homo sapiens_hsa047440.53864010
105RNA degradation_Homo sapiens_hsa030180.53716853
106Asthma_Homo sapiens_hsa053100.52914537
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51279305
108Inositol phosphate metabolism_Homo sapiens_hsa005620.50503446
109One carbon pool by folate_Homo sapiens_hsa006700.50243349
110Arginine biosynthesis_Homo sapiens_hsa002200.50205420
111Thyroid hormone synthesis_Homo sapiens_hsa049180.48859876
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48759139
113Gastric acid secretion_Homo sapiens_hsa049710.48110294
114Oxytocin signaling pathway_Homo sapiens_hsa049210.48043184
115Spliceosome_Homo sapiens_hsa030400.47141343
116Salivary secretion_Homo sapiens_hsa049700.46826173
117Gap junction_Homo sapiens_hsa045400.46699958
118Pancreatic secretion_Homo sapiens_hsa049720.46316505
119Nucleotide excision repair_Homo sapiens_hsa034200.45952438
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45437712
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45010509
122Parkinsons disease_Homo sapiens_hsa050120.44259975
123Alzheimers disease_Homo sapiens_hsa050100.43684882
124Protein digestion and absorption_Homo sapiens_hsa049740.40264385
125Sulfur metabolism_Homo sapiens_hsa009200.40063475
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39678337
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.38905223
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38771386
129Sulfur relay system_Homo sapiens_hsa041220.37759846
130Cocaine addiction_Homo sapiens_hsa050300.37757220
131Histidine metabolism_Homo sapiens_hsa003400.37346676
132Circadian rhythm_Homo sapiens_hsa047100.36838338
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36532289
134Proteasome_Homo sapiens_hsa030500.35894064
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.35599678
136cAMP signaling pathway_Homo sapiens_hsa040240.35377119
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35324734
138Primary immunodeficiency_Homo sapiens_hsa053400.35038877
139Fatty acid degradation_Homo sapiens_hsa000710.34676038
140Herpes simplex infection_Homo sapiens_hsa051680.33792965
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33646582
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33105587
143B cell receptor signaling pathway_Homo sapiens_hsa046620.32757875
144Fatty acid metabolism_Homo sapiens_hsa012120.32181523
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32163639
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32129276
147Circadian entrainment_Homo sapiens_hsa047130.31505808
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.31040522

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