OBFC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.79651592
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.79651592
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.56521707
4protein prenylation (GO:0018342)4.52132910
5prenylation (GO:0097354)4.52132910
6autophagic vacuole fusion (GO:0000046)4.32152285
7organelle membrane fusion (GO:0090174)4.21992008
8maturation of SSU-rRNA (GO:0030490)4.19317329
9cullin deneddylation (GO:0010388)4.15127316
10negative regulation of T cell receptor signaling pathway (GO:0050860)4.14523320
11DNA strand elongation involved in DNA replication (GO:0006271)4.10198763
12DNA replication initiation (GO:0006270)4.07673889
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04179445
14regulation of T cell receptor signaling pathway (GO:0050856)3.99751308
15protein deneddylation (GO:0000338)3.94965371
16formation of translation preinitiation complex (GO:0001731)3.93976499
17DNA strand elongation (GO:0022616)3.92432344
18response to interferon-beta (GO:0035456)3.84674001
19telomere maintenance via semi-conservative replication (GO:0032201)3.83998627
20positive regulation of gamma-delta T cell activation (GO:0046645)3.82905598
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81131934
22DNA deamination (GO:0045006)3.78171407
23regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.75525696
24regulation of B cell receptor signaling pathway (GO:0050855)3.71401652
25negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.70861180
26mitotic metaphase plate congression (GO:0007080)3.65681369
27anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65027539
28regulation of regulatory T cell differentiation (GO:0045589)3.64322164
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62611223
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62555961
31cellular response to interleukin-15 (GO:0071350)3.62254537
32mitotic recombination (GO:0006312)3.61125101
33telomere maintenance via recombination (GO:0000722)3.55599187
34regulation of gamma-delta T cell differentiation (GO:0045586)3.55203152
35DNA unwinding involved in DNA replication (GO:0006268)3.54017861
36antigen processing and presentation of endogenous antigen (GO:0019883)3.53900753
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.53549806
38negative regulation of ligase activity (GO:0051352)3.53549806
39DNA replication checkpoint (GO:0000076)3.51303187
40negative T cell selection (GO:0043383)3.50561408
41termination of RNA polymerase III transcription (GO:0006386)3.50466251
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.50466251
43negative regulation of T cell apoptotic process (GO:0070233)3.48181175
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47567784
45mast cell activation (GO:0045576)3.45021874
46nucleobase biosynthetic process (GO:0046112)3.38641311
47positive regulation of alpha-beta T cell proliferation (GO:0046641)3.34670762
48proteasome assembly (GO:0043248)3.31159067
49mast cell degranulation (GO:0043303)3.29609893
50mast cell activation involved in immune response (GO:0002279)3.29609893
51establishment of integrated proviral latency (GO:0075713)3.27535173
52regulation of alpha-beta T cell proliferation (GO:0046640)3.26367946
53viral transcription (GO:0019083)3.26194437
54spliceosomal complex assembly (GO:0000245)3.26071519
55response to interleukin-15 (GO:0070672)3.25364810
56transcription-coupled nucleotide-excision repair (GO:0006283)3.24055846
57negative thymic T cell selection (GO:0045060)3.22322622
58fucose catabolic process (GO:0019317)3.21829476
59L-fucose metabolic process (GO:0042354)3.21829476
60L-fucose catabolic process (GO:0042355)3.21829476
61metaphase plate congression (GO:0051310)3.21133854
62metallo-sulfur cluster assembly (GO:0031163)3.20851817
63iron-sulfur cluster assembly (GO:0016226)3.20851817
64translational termination (GO:0006415)3.20065587
65establishment of viral latency (GO:0019043)3.19727784
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19668298
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19574657
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19563799
69CENP-A containing nucleosome assembly (GO:0034080)3.18328798
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17381659
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17381659
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16804900
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16804900
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16804900
75ribosomal small subunit biogenesis (GO:0042274)3.16582624
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15530256
77spliceosomal snRNP assembly (GO:0000387)3.13057429
78ribosomal small subunit assembly (GO:0000028)3.12409132
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.11789562
80signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11789562
81regulation of gamma-delta T cell activation (GO:0046643)3.11663644
82purine nucleobase biosynthetic process (GO:0009113)3.11331624
83regulation of T cell apoptotic process (GO:0070232)3.11071075
84* telomere maintenance via telomere lengthening (GO:0010833)3.09394038
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.08363103
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08334011
87chromatin remodeling at centromere (GO:0031055)3.07213702
88viral mRNA export from host cell nucleus (GO:0046784)3.07086200
89positive regulation of ligase activity (GO:0051351)3.06516019
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06153797
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06153797
92mitotic nuclear envelope disassembly (GO:0007077)3.05655981
937-methylguanosine mRNA capping (GO:0006370)3.05410621
94negative regulation of thymocyte apoptotic process (GO:0070244)3.04707503
95G1/S transition of mitotic cell cycle (GO:0000082)3.04544401
96cell cycle G1/S phase transition (GO:0044843)3.04544401
97translational initiation (GO:0006413)3.03783682
98positive thymic T cell selection (GO:0045059)3.03363675
99adenosine metabolic process (GO:0046085)3.02526970
100RNA capping (GO:0036260)3.02066023
1017-methylguanosine RNA capping (GO:0009452)3.02066023
102ribosome assembly (GO:0042255)3.00423064
103establishment of chromosome localization (GO:0051303)3.00374778
104leukocyte degranulation (GO:0043299)2.98454647
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97958979
106purine deoxyribonucleotide catabolic process (GO:0009155)2.97790675
107eosinophil chemotaxis (GO:0048245)2.97575135
108positive regulation of mitotic sister chromatid separation (GO:1901970)2.97208841
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97208841
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97208841
111positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97051210
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96742108
113nucleotide-excision repair, DNA gap filling (GO:0006297)2.96737560
114ribonucleoprotein complex biogenesis (GO:0022613)2.96014604
115ribosome biogenesis (GO:0042254)2.95806940
116vesicle fusion (GO:0006906)2.95464449
117regulation of cellular amino acid metabolic process (GO:0006521)2.91795328
118sequestering of actin monomers (GO:0042989)2.89294967
119antigen processing and presentation via MHC class Ib (GO:0002475)2.89241650
120DNA replication-dependent nucleosome assembly (GO:0006335)2.88936548
121DNA replication-dependent nucleosome organization (GO:0034723)2.88936548
122cytidine metabolic process (GO:0046087)2.88613226
123cytidine catabolic process (GO:0006216)2.88613226
124cytidine deamination (GO:0009972)2.88613226
125rRNA processing (GO:0006364)2.88303375
126positive regulation of interleukin-8 secretion (GO:2000484)2.88293441
127translational elongation (GO:0006414)2.88202568
128regulation of ubiquitin-protein transferase activity (GO:0051438)2.88033953
129regulation of T cell mediated cytotoxicity (GO:0001914)2.87605180
130cellular response to interferon-beta (GO:0035458)2.85428651
131macrophage chemotaxis (GO:0048246)2.85270321
132antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84602168
133kinetochore organization (GO:0051383)2.83562570
134deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83390113
135ribosomal large subunit biogenesis (GO:0042273)2.83226539
136T cell migration (GO:0072678)2.81830155
137regulation of ligase activity (GO:0051340)2.81677351
138peptidyl-histidine modification (GO:0018202)2.81632022
139positive regulation of B cell differentiation (GO:0045579)2.80945158
140negative regulation of lymphocyte apoptotic process (GO:0070229)2.80682616
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80269604
142purine nucleotide salvage (GO:0032261)2.80249374
143membrane disassembly (GO:0030397)2.77577383
144nuclear envelope disassembly (GO:0051081)2.77577383
145rRNA metabolic process (GO:0016072)2.77225755
146DNA replication-independent nucleosome organization (GO:0034724)2.75632266
147DNA replication-independent nucleosome assembly (GO:0006336)2.75632266
148immunoglobulin mediated immune response (GO:0016064)2.75418108
149blastocyst development (GO:0001824)2.75278189
150negative regulation of mitotic sister chromatid separation (GO:2000816)2.74811022
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74811022
152negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74811022
153negative regulation of sister chromatid segregation (GO:0033046)2.74811022
154SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74433893
155positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.73328575
156cotranslational protein targeting to membrane (GO:0006613)2.72923435
157negative regulation of chromosome segregation (GO:0051985)2.72229440
158eosinophil migration (GO:0072677)2.71600742
159termination of RNA polymerase I transcription (GO:0006363)2.70866433
160nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70751751
161DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70751579
162spindle checkpoint (GO:0031577)2.70682417
163regulation of B cell differentiation (GO:0045577)2.70599281
164positive regulation of cell cycle arrest (GO:0071158)2.69568734
165positive T cell selection (GO:0043368)2.69355035
166transcription elongation from RNA polymerase I promoter (GO:0006362)2.68970354
167negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.68756318
168mitotic spindle assembly checkpoint (GO:0007094)2.67468295
169DNA damage response, detection of DNA damage (GO:0042769)2.67414651
170regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67011149
171regulation of leukocyte mediated cytotoxicity (GO:0001910)2.66709716
172regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.60713957
173actin nucleation (GO:0045010)2.60614283
174regulation of lymphocyte apoptotic process (GO:0070228)2.60560991
175negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60318459
176negative regulation of Ras GTPase activity (GO:0034261)2.59216028
177negative regulation of T-helper cell differentiation (GO:0045623)2.57910081
178negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57910081
179purine deoxyribonucleotide metabolic process (GO:0009151)2.55888572
180negative regulation of innate immune response (GO:0045824)2.54449416
181neutrophil activation involved in immune response (GO:0002283)2.53160329
182T cell receptor signaling pathway (GO:0050852)2.52377226
183regulation of interleukin-8 secretion (GO:2000482)2.46011277
184purine-containing compound salvage (GO:0043101)2.46008277
185antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.45025935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.87740161
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.60393159
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.23451541
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74714216
5GATA1_22025678_ChIP-Seq_K562_Human3.51267091
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.38412909
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.35426228
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34512306
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.26779001
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26246968
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20588892
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.17997458
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08368172
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03354394
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97537921
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96906683
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.95630991
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87991608
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81233611
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.80552754
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79360204
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76916109
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74920760
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72456901
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71947888
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62402310
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58912565
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48653498
29* MYB_26560356_Chip-Seq_TH2_Human2.46235281
30* XRN2_22483619_ChIP-Seq_HELA_Human2.42200770
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39140774
32RUNX_20019798_ChIP-Seq_JUKART_Human2.39010114
33VDR_23849224_ChIP-Seq_CD4+_Human2.35106959
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29542679
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22473786
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13353234
37ELK1_19687146_ChIP-ChIP_HELA_Human2.07470368
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00276115
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96989358
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96167201
41DCP1A_22483619_ChIP-Seq_HELA_Human1.95899299
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94807491
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.94210065
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92081506
45FOXP3_21729870_ChIP-Seq_TREG_Human1.90819020
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89645468
47TTF2_22483619_ChIP-Seq_HELA_Human1.89271517
48AR_21909140_ChIP-Seq_LNCAP_Human1.84858137
49VDR_22108803_ChIP-Seq_LS180_Human1.83805784
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80115726
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79278294
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.77256221
53* GABP_19822575_ChIP-Seq_HepG2_Human1.73691748
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72074798
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70946063
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67664499
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66788184
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66543336
59MYB_26560356_Chip-Seq_TH1_Human1.64622370
60* GATA3_27048872_Chip-Seq_THYMUS_Human1.64316644
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63581578
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62431822
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61707779
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60846313
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.60284455
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.58984077
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57903136
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57565560
69GATA3_26560356_Chip-Seq_TH2_Human1.55289318
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51421566
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49171561
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48554485
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.48387790
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47176086
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47081070
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.46774601
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42812130
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39754821
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.39290282
80* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36513990
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34843908
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34459911
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34240931
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33530162
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32382770
86CIITA_25753668_ChIP-Seq_RAJI_Human1.32156854
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29730786
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28085547
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26683349
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.26544943
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24830887
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24583497
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23883848
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23316921
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23176926
96MYC_18940864_ChIP-ChIP_HL60_Human1.22312110
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21981511
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20696689
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.20275887
100UTX_26944678_Chip-Seq_JUKART_Human1.19903019
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19768757
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.19124480
103* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18741702
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18052866
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.16622338
106KDM5A_27292631_Chip-Seq_BREAST_Human1.15016436
107* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10517246
108* MAF_26560356_Chip-Seq_TH1_Human1.10119759
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10007341
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09453684
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09417111
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04753654
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03316784
114MAF_26560356_Chip-Seq_TH2_Human1.02341763
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00243320
116TFEB_21752829_ChIP-Seq_HELA_Human0.99973204
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99918322
118* SOX17_20123909_ChIP-Seq_XEN_Mouse0.99283158
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98703494
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98154028
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97732102
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97611872
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97022144
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96959245
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95595318
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95558377
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94937555
128* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94317111
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94260149
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92865126
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92672315
132GATA3_26560356_Chip-Seq_TH1_Human0.92240398
133FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92093099
134GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92074094
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91099588
136BCL6_27268052_Chip-Seq_Bcells_Human0.90876845
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90669435
138* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90577774
139SPI1_23127762_ChIP-Seq_K562_Human0.89671674
140* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89584632
141NANOG_16153702_ChIP-ChIP_HESCs_Human0.88847180
142SCL_19346495_ChIP-Seq_HPC-7_Human0.88650712
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88211439
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.87076430
145CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86939125
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.86126179
147SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85882576
148STAT1_20625510_ChIP-Seq_HELA_Human0.85792686
149* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83306188
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83249280
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82801788
152AR_20517297_ChIP-Seq_VCAP_Human0.82701110
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80775801
154* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80337290
155SPI1_23547873_ChIP-Seq_NB4_Human0.78966471
156* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78102577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.66937618
2MP0004957_abnormal_blastocyst_morpholog3.58079410
3MP0003693_abnormal_embryo_hatching3.53579175
4MP0001835_abnormal_antigen_presentation3.38567698
5MP0003111_abnormal_nucleus_morphology3.23281821
6MP0003077_abnormal_cell_cycle3.23121673
7MP0008057_abnormal_DNA_replication3.02360336
8MP0008058_abnormal_DNA_repair3.01190912
9MP0003724_increased_susceptibility_to2.95823247
10MP0008007_abnormal_cellular_replicative2.80628306
11MP0006082_CNS_inflammation2.60945112
12MP0002166_altered_tumor_susceptibility2.54997996
13MP0003436_decreased_susceptibility_to2.54448992
14MP0009785_altered_susceptibility_to2.53661170
15MP0003950_abnormal_plasma_membrane2.52714892
16MP0003303_peritoneal_inflammation2.52072984
17MP0005000_abnormal_immune_tolerance2.51696900
18MP0008932_abnormal_embryonic_tissue2.46873897
19MP0001800_abnormal_humoral_immune2.46503619
20MP0000685_abnormal_immune_system2.35146475
21MP0002723_abnormal_immune_serum2.23456197
22MP0002420_abnormal_adaptive_immunity2.21197164
23MP0000537_abnormal_urethra_morphology2.20511916
24MP0002452_abnormal_antigen_presenting2.20442984
25MP0005464_abnormal_platelet_physiology2.20268975
26MP0010030_abnormal_orbit_morphology2.18733189
27MP0001819_abnormal_immune_cell2.17951914
28MP0005075_abnormal_melanosome_morpholog2.13616275
29MP0005025_abnormal_response_to2.13218705
30MP0002148_abnormal_hypersensitivity_rea2.13025594
31MP0003806_abnormal_nucleotide_metabolis2.10657624
32MP0000465_gastrointestinal_hemorrhage2.09451372
33MP0002006_tumorigenesis2.05222169
34MP0002419_abnormal_innate_immunity1.93752088
35MP0001730_embryonic_growth_arrest1.92892423
36MP0005387_immune_system_phenotype1.91818444
37MP0001790_abnormal_immune_system1.91818444
38MP0003786_premature_aging1.91117372
39MP0003123_paternal_imprinting1.91050217
40MP0003718_maternal_effect1.87441561
41MP0010155_abnormal_intestine_physiology1.72950418
42MP0000716_abnormal_immune_system1.69997127
43MP0003191_abnormal_cellular_cholesterol1.68407806
44MP0003315_abnormal_perineum_morphology1.66700177
45MP0005084_abnormal_gallbladder_morpholo1.66355260
46MP0004133_heterotaxia1.65247319
47MP0000350_abnormal_cell_proliferation1.61697092
48MP0001845_abnormal_inflammatory_respons1.60979233
49MP0003866_abnormal_defecation1.57660772
50MP0005671_abnormal_response_to1.49535622
51MP0002429_abnormal_blood_cell1.42569525
52MP0002249_abnormal_larynx_morphology1.39254112
53MP0000049_abnormal_middle_ear1.38859682
54MP0003763_abnormal_thymus_physiology1.36534525
55MP0009333_abnormal_splenocyte_physiolog1.36316303
56MP0002085_abnormal_embryonic_tissue1.36020765
57MP0001533_abnormal_skeleton_physiology1.35241453
58MP0008469_abnormal_protein_level1.34384928
59MP0002132_abnormal_respiratory_system1.33389753
60MP0001663_abnormal_digestive_system1.32589375
61MP0002102_abnormal_ear_morphology1.32109971
62MP0005397_hematopoietic_system_phenotyp1.31515176
63MP0001545_abnormal_hematopoietic_system1.31515176
64MP0009697_abnormal_copulation1.29504091
65MP0004147_increased_porphyrin_level1.28799906
66MP0001672_abnormal_embryogenesis/_devel1.27643295
67MP0005380_embryogenesis_phenotype1.27643295
68MP0003941_abnormal_skin_development1.26567793
69MP0002396_abnormal_hematopoietic_system1.26447204
70MP0005171_absent_coat_pigmentation1.25710789
71MP0003828_pulmonary_edema1.24585266
72MP0001697_abnormal_embryo_size1.24299784
73MP0003937_abnormal_limbs/digits/tail_de1.23995023
74MP0003121_genomic_imprinting1.23238946
75MP0009764_decreased_sensitivity_to1.22848198
76MP0005166_decreased_susceptibility_to1.22836322
77MP0002938_white_spotting1.19948736
78MP0003938_abnormal_ear_development1.19722170
79MP0003567_abnormal_fetal_cardiomyocyte1.19579938
80MP0006036_abnormal_mitochondrial_physio1.17456931
81MP0002084_abnormal_developmental_patter1.16206461
82MP0001879_abnormal_lymphatic_vessel1.15036181
83MP0003656_abnormal_erythrocyte_physiolo1.14543663
84MP0005367_renal/urinary_system_phenotyp1.13790564
85MP0000516_abnormal_urinary_system1.13790564
86MP0002080_prenatal_lethality1.13664583
87MP0001873_stomach_inflammation1.13089516
88MP0001529_abnormal_vocalization1.11915780
89MP0003119_abnormal_digestive_system1.11785933
90MP0003984_embryonic_growth_retardation1.11037627
91MP0003279_aneurysm1.10695550
92MP0001664_abnormal_digestion1.06735477
93MP0008877_abnormal_DNA_methylation1.06627833
94MP0002405_respiratory_system_inflammati1.06617824
95MP0000703_abnormal_thymus_morphology1.05471762
96MP0002088_abnormal_embryonic_growth/wei1.05443714
97MP0004272_abnormal_basement_membrane1.04595425
98MP0010352_gastrointestinal_tract_polyps1.03728652
99MP0001293_anophthalmia1.03569233
100MP0000313_abnormal_cell_death1.02972356
101MP0005503_abnormal_tendon_morphology1.01339662
102MP0000566_synostosis1.00968493
103MP0009763_increased_sensitivity_to1.00080734
104MP0004043_abnormal_pH_regulation0.99794231
105MP0002019_abnormal_tumor_incidence0.99440520
106MP0005165_increased_susceptibility_to0.99301716
107MP0008438_abnormal_cutaneous_collagen0.98753298
108MP0006292_abnormal_olfactory_placode0.98635998
109MP0008260_abnormal_autophagy0.98113313
110MP0005023_abnormal_wound_healing0.96473144
111MP0000372_irregular_coat_pigmentation0.96175539
112MP0002086_abnormal_extraembryonic_tissu0.95177035
113MP0003221_abnormal_cardiomyocyte_apopto0.94958214
114MP0004947_skin_inflammation0.94920032
115MP0001853_heart_inflammation0.92757195
116MP0000490_abnormal_crypts_of0.92434272
117MP0002111_abnormal_tail_morphology0.92251213
118MP0003252_abnormal_bile_duct0.90818164
119MP0002653_abnormal_ependyma_morphology0.90467719
120MP0009250_abnormal_appendicular_skeleto0.89340565
121MP0004197_abnormal_fetal_growth/weight/0.88651578
122MP0002877_abnormal_melanocyte_morpholog0.87791982
123MP0005083_abnormal_biliary_tract0.87536254
124MP0003075_altered_response_to0.86924856
125MP0003942_abnormal_urinary_system0.86470879
126MP0000762_abnormal_tongue_morphology0.85161175
127MP0003186_abnormal_redox_activity0.84837026
128MP0005381_digestive/alimentary_phenotyp0.84800188
129MP0009643_abnormal_urine_homeostasis0.84596651
130MP0001919_abnormal_reproductive_system0.84364263
131MP0005164_abnormal_response_to0.82987829
132MP0001764_abnormal_homeostasis0.81373541
133MP0001243_abnormal_dermal_layer0.81347929
134MP0003755_abnormal_palate_morphology0.80936420
135MP0002932_abnormal_joint_morphology0.80888404
136MP0002163_abnormal_gland_morphology0.80632972
137MP0000858_altered_metastatic_potential0.80513948
138MP0003136_yellow_coat_color0.80264475
139MP0002722_abnormal_immune_system0.80137886
140MP0001851_eye_inflammation0.80115987
141MP0005319_abnormal_enzyme/_coenzyme0.79995438
142MP0001286_abnormal_eye_development0.79570900
143MP0002210_abnormal_sex_determination0.79242845
144MP0002136_abnormal_kidney_physiology0.78602358
145MP0005174_abnormal_tail_pigmentation0.78543369
146MP0003385_abnormal_body_wall0.78402554
147MP0004484_altered_response_of0.77755756
148MP0001542_abnormal_bone_strength0.77063752
149MP0002127_abnormal_cardiovascular_syste0.76027622
150MP0008872_abnormal_physiological_respon0.75373865
151MP0002398_abnormal_bone_marrow0.75125279
152MP0005508_abnormal_skeleton_morphology0.74956157
153MP0002837_dystrophic_cardiac_calcinosis0.74031838
154MP0002751_abnormal_autonomic_nervous0.73960724
155MP0002332_abnormal_exercise_endurance0.73920555
156MP0000750_abnormal_muscle_regeneration0.73905129
157MP0003638_abnormal_response/metabolism_0.73819836
158MP0009840_abnormal_foam_cell0.73629136
159MP0000015_abnormal_ear_pigmentation0.73206669
160MP0005409_darkened_coat_color0.72633450
161MP0000689_abnormal_spleen_morphology0.72476124
162MP0002693_abnormal_pancreas_physiology0.72430964
163MP0008875_abnormal_xenobiotic_pharmacok0.71593471
164MP0002114_abnormal_axial_skeleton0.71512036
165MP0002138_abnormal_hepatobiliary_system0.71195760
166MP0000343_altered_response_to0.69654350
167MP0005389_reproductive_system_phenotype0.69596427
168MP0004381_abnormal_hair_follicle0.69078649
169MP0005390_skeleton_phenotype0.67799818
170MP0001145_abnormal_male_reproductive0.67667531
171MP0010386_abnormal_urinary_bladder0.67008873
172MP0000358_abnormal_cell_content/0.66528761
173MP0003448_altered_tumor_morphology0.65991155
174MP0000432_abnormal_head_morphology0.65746727
175MP0009379_abnormal_foot_pigmentation0.64931481
176MP0002933_joint_inflammation0.64171574
177MP0010368_abnormal_lymphatic_system0.63658410
178MP0003936_abnormal_reproductive_system0.62600032
179MP0000767_abnormal_smooth_muscle0.61517559
180MP0006054_spinal_hemorrhage0.61407382

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.32654262
2Birth length less than 3rd percentile (HP:0003561)4.07915136
3Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.95087533
4Breast hypoplasia (HP:0003187)3.58238175
5Stomatitis (HP:0010280)3.56634205
6Selective tooth agenesis (HP:0001592)3.38196671
7Abnormality of T cell number (HP:0011839)3.37306237
8Cerebral hypomyelination (HP:0006808)3.33989867
9Reticulocytopenia (HP:0001896)3.21475118
10Abnormality of fatty-acid metabolism (HP:0004359)3.17116908
11Autoimmune hemolytic anemia (HP:0001890)3.11911139
12Abnormal number of incisors (HP:0011064)3.08548612
13Abnormality of T cells (HP:0002843)3.07256864
14Stenosis of the external auditory canal (HP:0000402)2.99612435
15Hypoproteinemia (HP:0003075)2.91506251
16Rhabdomyolysis (HP:0003201)2.86167580
17Abnormality of the fetal cardiovascular system (HP:0010948)2.85409422
18Abnormal umbilical cord blood vessels (HP:0011403)2.85409422
19Single umbilical artery (HP:0001195)2.85409422
20Patellar aplasia (HP:0006443)2.76770407
21Dry hair (HP:0011359)2.75757147
22Abnormal lung lobation (HP:0002101)2.75292595
23Abnormality of the umbilical cord (HP:0010881)2.73864257
24Myoglobinuria (HP:0002913)2.71349429
25Panhypogammaglobulinemia (HP:0003139)2.67001152
26Progressive muscle weakness (HP:0003323)2.66542156
27Abnormality of the prostate (HP:0008775)2.64696666
28Supernumerary spleens (HP:0009799)2.59033342
29Thyroiditis (HP:0100646)2.58147684
30Myositis (HP:0100614)2.57693528
31Aplasia/Hypoplasia of the patella (HP:0006498)2.56773012
32Abnormality of eosinophils (HP:0001879)2.55969361
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55505936
34Meckel diverticulum (HP:0002245)2.55150812
35Palpitations (HP:0001962)2.53818892
36Absent radius (HP:0003974)2.51270957
37Large for gestational age (HP:0001520)2.50789847
38Abnormality of the ileum (HP:0001549)2.49656423
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.48125768
40Rough bone trabeculation (HP:0100670)2.47969439
41IgM deficiency (HP:0002850)2.47063455
42Premature graying of hair (HP:0002216)2.46294822
43Recurrent cutaneous fungal infections (HP:0011370)2.43361594
44Chronic mucocutaneous candidiasis (HP:0002728)2.43361594
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41863393
46Recurrent fungal infections (HP:0002841)2.41425473
47Acute hepatic failure (HP:0006554)2.40581490
48Abnormality of the anterior horn cell (HP:0006802)2.39603518
49Degeneration of anterior horn cells (HP:0002398)2.39603518
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.38805448
51Abnormality of B cell number (HP:0010975)2.37951261
52B lymphocytopenia (HP:0010976)2.37456750
53Abnormality of T cell physiology (HP:0011840)2.36138072
54Absent forearm bone (HP:0003953)2.36000236
55Aplasia involving forearm bones (HP:0009822)2.36000236
56Abnormality of the renal collecting system (HP:0004742)2.32614248
57Chronic diarrhea (HP:0002028)2.31115157
58Asplenia (HP:0001746)2.30999850
59Reduced subcutaneous adipose tissue (HP:0003758)2.30403142
60Brushfield spots (HP:0001088)2.29809645
61Lactic acidosis (HP:0003128)2.29064269
62Renal cortical cysts (HP:0000803)2.28606862
63Agammaglobulinemia (HP:0004432)2.27523300
64Increased serum pyruvate (HP:0003542)2.27513327
65Abnormality of glycolysis (HP:0004366)2.27513327
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27294476
67Abnormal protein N-linked glycosylation (HP:0012347)2.27294476
68Abnormal protein glycosylation (HP:0012346)2.27294476
69Abnormal glycosylation (HP:0012345)2.27294476
70Recurrent bronchitis (HP:0002837)2.26676982
71Menstrual irregularities (HP:0000858)2.25684107
72Abnormality of the preputium (HP:0100587)2.25585234
73Carpal bone hypoplasia (HP:0001498)2.24488260
74Reduced antithrombin III activity (HP:0001976)2.22898729
75Macrocytic anemia (HP:0001972)2.21649840
76Microretrognathia (HP:0000308)2.21288356
77Increased intramyocellular lipid droplets (HP:0012240)2.20678351
78Pustule (HP:0200039)2.19928384
79Granulocytopenia (HP:0001913)2.19255902
80Duodenal stenosis (HP:0100867)2.19091170
81Small intestinal stenosis (HP:0012848)2.19091170
82Encephalitis (HP:0002383)2.17821023
83Metaphyseal dysplasia (HP:0100255)2.17451935
84Eosinophilia (HP:0001880)2.16885835
85Joint swelling (HP:0001386)2.14982314
86Hepatic necrosis (HP:0002605)2.14304033
87Colon cancer (HP:0003003)2.13909278
88Increased IgM level (HP:0003496)2.13704948
89Abnormality of cells of the erythroid lineage (HP:0012130)2.13233614
90Abnormality of the aortic arch (HP:0012303)2.12981821
91Triphalangeal thumb (HP:0001199)2.12661593
92Meningitis (HP:0001287)2.11775374
93Chromsome breakage (HP:0040012)2.10633353
94Abnormal rod and cone electroretinograms (HP:0008323)2.10346330
95Aplastic anemia (HP:0001915)2.08625323
96Absent epiphyses (HP:0010577)2.08562093
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08562093
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07640574
99Dicarboxylic aciduria (HP:0003215)2.07640574
100Abnormality of the labia minora (HP:0012880)2.07118635
101Duplicated collecting system (HP:0000081)2.07041038
102Steatorrhea (HP:0002570)2.06990300
103Petechiae (HP:0000967)2.05832449
104Vasculitis (HP:0002633)2.04658507
1053-Methylglutaconic aciduria (HP:0003535)2.03677950
106Leukocytosis (HP:0001974)2.03418724
107Pulmonary infiltrates (HP:0002113)2.02900241
108Ectopic kidney (HP:0000086)2.02824132
109Skin rash (HP:0000988)2.02367298
110Aplasia/Hypoplasia of the uvula (HP:0010293)2.01649102
111Abnormal mitochondria in muscle tissue (HP:0008316)1.98578267
112Oral leukoplakia (HP:0002745)1.98413854
113Abnormality of chromosome stability (HP:0003220)1.97499025
114Hepatocellular necrosis (HP:0001404)1.97153288
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96669476
116Acute necrotizing encephalopathy (HP:0006965)1.96118720
117Decreased central vision (HP:0007663)1.95858932
118Polyneuropathy (HP:0001271)1.95336867
119Chronic obstructive pulmonary disease (HP:0006510)1.94967028
120Obstructive lung disease (HP:0006536)1.94967028
121Abnormality of the alveolar ridges (HP:0006477)1.94953588
122Atresia of the external auditory canal (HP:0000413)1.94949645
123Recurrent skin infections (HP:0001581)1.93040925
124Anhidrosis (HP:0000970)1.92842503
125Recurrent abscess formation (HP:0002722)1.92535331
126Inflammation of the large intestine (HP:0002037)1.92462713
127Prostate neoplasm (HP:0100787)1.91986835
128Abnormality of macrophages (HP:0004311)1.90730159
129Increased muscle lipid content (HP:0009058)1.90067249
130Hepatosplenomegaly (HP:0001433)1.88436497
131Type 2 muscle fiber atrophy (HP:0003554)1.88159826
132Autoamputation (HP:0001218)1.87205104
133Severe combined immunodeficiency (HP:0004430)1.86187499
134Facial cleft (HP:0002006)1.85581754
135Abnormal spermatogenesis (HP:0008669)1.85530258
136Postnatal microcephaly (HP:0005484)1.85159756
137Orchitis (HP:0100796)1.84895558
138Slender long bone (HP:0003100)1.84191150
139Glossoptosis (HP:0000162)1.82418828
140Absent thumb (HP:0009777)1.82386362
141Renal Fanconi syndrome (HP:0001994)1.82002618
142Sloping forehead (HP:0000340)1.81717932
143Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81420340
144Abnormal number of erythroid precursors (HP:0012131)1.80909700
145Recurrent bacterial skin infections (HP:0005406)1.80566476
146Trismus (HP:0000211)1.80465488
147Horseshoe kidney (HP:0000085)1.80229306
148Gangrene (HP:0100758)1.79219646
149Erythema (HP:0010783)1.79136449
150Poor head control (HP:0002421)1.79085605
151Chest pain (HP:0100749)1.78926406
152Nephroblastoma (Wilms tumor) (HP:0002667)1.78876811
153Adrenal hypoplasia (HP:0000835)1.78487463
154Pulmonary fibrosis (HP:0002206)1.78349350
155Arterial thrombosis (HP:0004420)1.77896044
156Impulsivity (HP:0100710)1.77892839
157Mitochondrial inheritance (HP:0001427)1.77096173
158Cellular immunodeficiency (HP:0005374)1.77004723
159Rectal fistula (HP:0100590)1.76870925
160Rectovaginal fistula (HP:0000143)1.76870925
161Increased CSF lactate (HP:0002490)1.76066224
162Bone marrow hypocellularity (HP:0005528)1.75509947
163Nasolacrimal duct obstruction (HP:0000579)1.75347277
164Abnormal trabecular bone morphology (HP:0100671)1.74297234
165Bilateral microphthalmos (HP:0007633)1.73909637
166Esophageal atresia (HP:0002032)1.73227732
167Optic nerve coloboma (HP:0000588)1.72995043
168Embryonal renal neoplasm (HP:0011794)1.72726079
169Proximal placement of thumb (HP:0009623)1.71267577
170IgG deficiency (HP:0004315)1.70476209
171Abnormality of the duodenum (HP:0002246)1.70190438
172Ureteral duplication (HP:0000073)1.69289548
173Increased hepatocellular lipid droplets (HP:0006565)1.69254743
174Combined immunodeficiency (HP:0005387)1.69198571
175Cleft eyelid (HP:0000625)1.67825482
176Muscle fiber atrophy (HP:0100295)1.67653526
177Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67153559
178Neoplasm of the pancreas (HP:0002894)1.65038135
179Increased serum lactate (HP:0002151)1.64656341
180Congenital malformation of the right heart (HP:0011723)1.64628776
181Double outlet right ventricle (HP:0001719)1.64628776
182Spinal muscular atrophy (HP:0007269)1.64520958
183Pallor (HP:0000980)1.64445321
184Deviation of the thumb (HP:0009603)1.64285714
185Abnormalities of placenta or umbilical cord (HP:0001194)1.64216496
186T lymphocytopenia (HP:0005403)1.63417686
187Respiratory difficulties (HP:0002880)1.63102900
188Type I transferrin isoform profile (HP:0003642)1.62763936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.38809971
2WEE13.73058035
3MAP4K23.47994880
4TESK22.79526588
5BCKDK2.61740187
6TSSK62.52140524
7MAP3K112.51760853
8TAOK32.46756736
9EIF2AK12.45621522
10CDC72.41001796
11JAK32.32428187
12KDR2.32218062
13TLK12.12538377
14MAP2K32.11586585
15GRK62.10085515
16VRK12.09814752
17PBK2.03868649
18NME21.97081366
19MAP3K121.94846255
20MKNK11.94578889
21PASK1.91269311
22EIF2AK31.85779275
23STK101.85564326
24MST41.82550443
25TBK11.73777625
26TAOK11.70805156
27SRPK11.69950633
28KIT1.62235354
29PLK41.58061238
30EPHA21.57991132
31PLK11.57801508
32STK161.57248909
33MKNK21.57122620
34PLK31.52632527
35CDK71.51700039
36TGFBR11.51256381
37LIMK11.48967006
38IKBKE1.46448937
39SCYL21.44758434
40RIPK41.44722386
41VRK21.40111965
42ZAK1.37017610
43TTK1.36319226
44ACVR1B1.34103746
45TESK11.33004094
46TXK1.32216901
47TAOK21.30936410
48AURKB1.30310799
49PIM21.29302650
50MAP3K141.29138683
51BCR1.27410439
52BRSK21.23637622
53FES1.23419004
54NEK21.20209218
55CSF1R1.16629683
56ZAP701.15018743
57NME11.13902198
58AURKA1.13854281
59MAP3K81.11083835
60NUAK11.08502982
61ATR1.05820741
62SYK1.03992475
63PAK41.03026871
64FLT31.02657165
65IKBKB1.02263533
66CSK1.00001589
67PRKCQ0.99857945
68EIF2AK20.97727422
69BMPR20.96549962
70TIE10.96324111
71PIK3CG0.94975227
72CDK190.94048097
73CLK10.93918487
74TNK20.93097694
75MAP3K50.92038944
76BMPR1B0.91687410
77JAK10.91298034
78LRRK20.90516459
79DYRK20.87902067
80ABL20.87173570
81STK40.85507807
82RPS6KB20.83109591
83NEK10.81884001
84CHEK20.80689675
85PAK10.78325655
86MYLK0.77053148
87ITK0.76373746
88RPS6KA40.76368999
89BRAF0.72642826
90DAPK10.71832375
91MAPKAPK30.71277195
92LYN0.70683434
93MAP3K10.70286229
94MUSK0.69977488
95MATK0.69716824
96MAP4K10.69701316
97BRSK10.68945910
98TYK20.68727353
99GRK70.67732242
100DYRK30.67070398
101CHEK10.64720617
102CSNK2A10.64577420
103CDK80.63543478
104TEC0.61660745
105STK390.61497867
106PRKCI0.60011659
107MAP2K20.59934888
108CSNK2A20.59817193
109MELK0.56921039
110TRPM70.56839987
111FRK0.55550775
112YES10.54586536
113EPHB20.54216948
114HCK0.54098008
115FGFR10.53538345
116MAP3K30.52894469
117PIM10.52400262
118MST1R0.52315996
119MET0.52050099
120BTK0.51234695
121CCNB10.51059380
122PLK20.50157179
123ATM0.48055853
124AKT30.47563368
125PDK20.46147932
126IGF1R0.45768786
127RPS6KA50.45463272
128TGFBR20.44835719
129CDK20.44122002
130CDK180.43049056
131CDK10.42985215
132PTK2B0.42471448
133CDK11A0.42438769
134TNIK0.41237207
135PNCK0.41178294
136OBSCN0.39831485
137ROCK20.39633776
138ADRBK20.39546032
139STK38L0.39205469
140ADRBK10.38941378
141LCK0.38806840
142CDK150.38338529
143GRK10.37852459
144IRAK40.37551087
145CASK0.36659336
146ILK0.36275925
147CDK30.36205569
148ABL10.35367246
149OXSR10.35042537
150CDK140.33539806
151MARK30.33062407
152LMTK20.29620925
153PHKG20.28630636
154PHKG10.28630636
155ERN10.26809502
156MAPKAPK20.25941374
157ERBB30.24222164
158NEK60.22586455

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.12967510
2DNA replication_Homo sapiens_hsa030303.90281130
3RNA polymerase_Homo sapiens_hsa030203.54406724
4SNARE interactions in vesicular transport_Homo sapiens_hsa041303.33827137
5Ribosome_Homo sapiens_hsa030103.30753844
6Mismatch repair_Homo sapiens_hsa034303.28598755
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.99898485
8Spliceosome_Homo sapiens_hsa030402.89527409
9Homologous recombination_Homo sapiens_hsa034402.86592792
10Nucleotide excision repair_Homo sapiens_hsa034202.71720715
11Base excision repair_Homo sapiens_hsa034102.52734090
12RNA transport_Homo sapiens_hsa030132.51731659
13Cell cycle_Homo sapiens_hsa041102.36936519
14Pyrimidine metabolism_Homo sapiens_hsa002402.17807999
15Type I diabetes mellitus_Homo sapiens_hsa049402.15921565
16Non-homologous end-joining_Homo sapiens_hsa034502.12073782
17Fanconi anemia pathway_Homo sapiens_hsa034602.06362114
18Basal transcription factors_Homo sapiens_hsa030221.94500401
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92018384
20One carbon pool by folate_Homo sapiens_hsa006701.69686471
21RNA degradation_Homo sapiens_hsa030181.67409525
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51586401
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41411491
24Primary immunodeficiency_Homo sapiens_hsa053401.40878407
25Oxidative phosphorylation_Homo sapiens_hsa001901.38384815
26p53 signaling pathway_Homo sapiens_hsa041151.36774594
27Peroxisome_Homo sapiens_hsa041461.36769053
28Leishmaniasis_Homo sapiens_hsa051401.32405240
29Purine metabolism_Homo sapiens_hsa002301.32185008
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29724843
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28732575
32Propanoate metabolism_Homo sapiens_hsa006401.28592912
33Rheumatoid arthritis_Homo sapiens_hsa053231.28209043
34Epstein-Barr virus infection_Homo sapiens_hsa051691.26586154
35Parkinsons disease_Homo sapiens_hsa050121.24779447
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22527757
37mRNA surveillance pathway_Homo sapiens_hsa030151.18851520
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18354031
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15144482
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12650097
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09962599
42Huntingtons disease_Homo sapiens_hsa050161.09686038
43Protein export_Homo sapiens_hsa030601.06835447
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05787226
45Antigen processing and presentation_Homo sapiens_hsa046121.05665101
46Basal cell carcinoma_Homo sapiens_hsa052170.99801908
47Graft-versus-host disease_Homo sapiens_hsa053320.97550681
48HTLV-I infection_Homo sapiens_hsa051660.89886791
49Staphylococcus aureus infection_Homo sapiens_hsa051500.89799989
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88399806
51Hippo signaling pathway_Homo sapiens_hsa043900.86747055
52Hedgehog signaling pathway_Homo sapiens_hsa043400.84285590
53Viral myocarditis_Homo sapiens_hsa054160.81518974
54Viral carcinogenesis_Homo sapiens_hsa052030.80405425
55Regulation of autophagy_Homo sapiens_hsa041400.77451136
56Systemic lupus erythematosus_Homo sapiens_hsa053220.76395569
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76005127
58Caffeine metabolism_Homo sapiens_hsa002320.75990297
59Oocyte meiosis_Homo sapiens_hsa041140.74945212
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74798229
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74102128
62Shigellosis_Homo sapiens_hsa051310.71840677
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70875111
64TGF-beta signaling pathway_Homo sapiens_hsa043500.69901812
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.69065658
66Tryptophan metabolism_Homo sapiens_hsa003800.68491420
67Herpes simplex infection_Homo sapiens_hsa051680.68164017
68Alzheimers disease_Homo sapiens_hsa050100.66473671
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.63983421
70Influenza A_Homo sapiens_hsa051640.63360776
71Allograft rejection_Homo sapiens_hsa053300.62760372
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62744376
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62687058
74Adherens junction_Homo sapiens_hsa045200.62265409
75Hematopoietic cell lineage_Homo sapiens_hsa046400.61460172
76Steroid biosynthesis_Homo sapiens_hsa001000.61166971
77Tuberculosis_Homo sapiens_hsa051520.59476095
78Other glycan degradation_Homo sapiens_hsa005110.58612760
79Osteoclast differentiation_Homo sapiens_hsa043800.58531425
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57641233
81Sulfur metabolism_Homo sapiens_hsa009200.56936759
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56343206
83Measles_Homo sapiens_hsa051620.56165152
84B cell receptor signaling pathway_Homo sapiens_hsa046620.55656249
85Autoimmune thyroid disease_Homo sapiens_hsa053200.54752369
86Fatty acid elongation_Homo sapiens_hsa000620.53639719
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53106141
88T cell receptor signaling pathway_Homo sapiens_hsa046600.51606711
89MicroRNAs in cancer_Homo sapiens_hsa052060.50411884
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50384122
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49920645
92Toxoplasmosis_Homo sapiens_hsa051450.48394862
93Glutathione metabolism_Homo sapiens_hsa004800.47859925
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46561343
95Butanoate metabolism_Homo sapiens_hsa006500.46273024
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.45442455
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.45376049
98Carbon metabolism_Homo sapiens_hsa012000.44989597
99Pentose phosphate pathway_Homo sapiens_hsa000300.44913877
100Salmonella infection_Homo sapiens_hsa051320.43272874
101TNF signaling pathway_Homo sapiens_hsa046680.43030878
102Arachidonic acid metabolism_Homo sapiens_hsa005900.41858601
103Small cell lung cancer_Homo sapiens_hsa052220.41648605
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.41443264
105Phototransduction_Homo sapiens_hsa047440.41310084
106Nitrogen metabolism_Homo sapiens_hsa009100.40486118
107Tight junction_Homo sapiens_hsa045300.40176535
108Apoptosis_Homo sapiens_hsa042100.40126485
109Vitamin B6 metabolism_Homo sapiens_hsa007500.39456109
110Glycerolipid metabolism_Homo sapiens_hsa005610.39101814
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39066827
112Malaria_Homo sapiens_hsa051440.38967535
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.38822428
114Legionellosis_Homo sapiens_hsa051340.38192953
115Pathways in cancer_Homo sapiens_hsa052000.38084660
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38077495
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37546432
118Wnt signaling pathway_Homo sapiens_hsa043100.37450365
119Circadian rhythm_Homo sapiens_hsa047100.37417008
120Asthma_Homo sapiens_hsa053100.37184565
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.35648694
122Chemical carcinogenesis_Homo sapiens_hsa052040.35078426
123Sphingolipid metabolism_Homo sapiens_hsa006000.34869692
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.33729057
125Thyroid cancer_Homo sapiens_hsa052160.33026196
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31829587
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31656594
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30971149
129Notch signaling pathway_Homo sapiens_hsa043300.30679932
130Ether lipid metabolism_Homo sapiens_hsa005650.30596251
131Alcoholism_Homo sapiens_hsa050340.30589548
132Folate biosynthesis_Homo sapiens_hsa007900.30041016
133ECM-receptor interaction_Homo sapiens_hsa045120.29361647
134Biosynthesis of amino acids_Homo sapiens_hsa012300.29046438
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27297716
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26625312
137Fructose and mannose metabolism_Homo sapiens_hsa000510.26613967
138Colorectal cancer_Homo sapiens_hsa052100.25532629
139Hepatitis B_Homo sapiens_hsa051610.23494420
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22731239
141Metabolic pathways_Homo sapiens_hsa011000.21730937
142Cardiac muscle contraction_Homo sapiens_hsa042600.18950481
143HIF-1 signaling pathway_Homo sapiens_hsa040660.18337066
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18055574

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