OBP2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sensory perception of chemical stimulus (GO:0007606)8.99158714
2cellular response to dexamethasone stimulus (GO:0071549)8.78976758
3positive regulation of synaptic transmission, glutamatergic (GO:0051968)8.49538873
4response to dexamethasone (GO:0071548)8.19513596
5dermatan sulfate biosynthetic process (GO:0030208)8.04078444
6gland morphogenesis (GO:0022612)7.79720333
7dermatan sulfate metabolic process (GO:0030205)7.76015435
8morphogenesis of an epithelial fold (GO:0060571)7.46920116
9cellular response to estradiol stimulus (GO:0071392)7.17385470
10chondroitin sulfate catabolic process (GO:0030207)7.05474262
11regulation of superoxide metabolic process (GO:0090322)6.92617475
12protein localization to cilium (GO:0061512)6.59393145
13positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)6.44895274
14cellular response to epidermal growth factor stimulus (GO:0071364)6.29561659
15digestive tract morphogenesis (GO:0048546)6.15063007
16ethanol oxidation (GO:0006069)6.12013198
17cellular glucuronidation (GO:0052695)5.71124954
18regulation of catenin import into nucleus (GO:0035412)5.55241069
19uronic acid metabolic process (GO:0006063)5.48421038
20glucuronate metabolic process (GO:0019585)5.48421038
21regulation of cholesterol biosynthetic process (GO:0045540)5.34996807
22regulation of beta-amyloid formation (GO:1902003)5.30930011
23Notch signaling involved in heart development (GO:0061314)5.19586383
24one-carbon compound transport (GO:0019755)5.18680572
25response to epidermal growth factor (GO:0070849)5.10968894
26cellular response to estrogen stimulus (GO:0071391)5.04309438
27heart valve formation (GO:0003188)4.96224984
28cerebral cortex cell migration (GO:0021795)4.82378801
29hyperosmotic salinity response (GO:0042538)4.79343757
30embryonic placenta development (GO:0001892)4.74644574
31cellular response to ketone (GO:1901655)4.73904549
32positive regulation of cellular amide metabolic process (GO:0034250)4.73630139
33astrocyte differentiation (GO:0048708)4.69956554
34ethanol metabolic process (GO:0006067)4.68798474
35antibacterial humoral response (GO:0019731)4.51886467
36positive regulation of digestive system process (GO:0060456)4.49808109
37epoxygenase P450 pathway (GO:0019373)4.49664190
38positive regulation of vasoconstriction (GO:0045907)4.47978658
39response to dietary excess (GO:0002021)4.41450919
40endocardial cushion morphogenesis (GO:0003203)4.39883260
41cellular response to glucocorticoid stimulus (GO:0071385)4.38690818
42regulation of amyloid precursor protein catabolic process (GO:1902991)4.32017331
43flavonoid metabolic process (GO:0009812)4.30885462
44neuronal stem cell maintenance (GO:0097150)4.30875811
45positive regulation of vasodilation (GO:0045909)4.21135416
46antimicrobial humoral response (GO:0019730)4.19545047
47lateral ventricle development (GO:0021670)4.17198319
48cellular response to corticosteroid stimulus (GO:0071384)4.08443369
49ventricular trabecula myocardium morphogenesis (GO:0003222)4.07838055
50tachykinin receptor signaling pathway (GO:0007217)3.99797741
51exogenous drug catabolic process (GO:0042738)3.85464483
52adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.85090832
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.79003177
54epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.78676671
55regulation of cholesterol metabolic process (GO:0090181)3.78009326
56telencephalon cell migration (GO:0022029)3.77244036
57positive regulation of nitric oxide biosynthetic process (GO:0045429)3.75912455
58regulation of sodium ion transmembrane transport (GO:1902305)3.75638800
59activation of protein kinase A activity (GO:0034199)3.75598518
60negative regulation of oligodendrocyte differentiation (GO:0048715)3.75135034
61chondroitin sulfate biosynthetic process (GO:0030206)3.72876229
62hormone catabolic process (GO:0042447)3.69245865
63negative regulation of lipase activity (GO:0060192)3.67790730
64mating behavior (GO:0007617)3.67423109
65hair follicle development (GO:0001942)3.64498501
66positive regulation of DNA repair (GO:0045739)3.58552231
67negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.53720901
68coronary vasculature morphogenesis (GO:0060977)3.52186444
69mesenchyme morphogenesis (GO:0072132)3.51979847
70sulfur amino acid catabolic process (GO:0000098)3.47654019
71cGMP-mediated signaling (GO:0019934)3.47423259
72heart trabecula morphogenesis (GO:0061384)3.45350527
73regulation of nitric-oxide synthase activity (GO:0050999)3.43556851
74forebrain cell migration (GO:0021885)3.43378954
75regulation of sodium ion transmembrane transporter activity (GO:2000649)3.38179815
76alkaloid metabolic process (GO:0009820)3.38017272
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37607191
78regulation of somitogenesis (GO:0014807)3.36633896
79drug catabolic process (GO:0042737)3.33684544
80epithelial cell differentiation involved in prostate gland development (GO:0060742)3.32993257
81water-soluble vitamin biosynthetic process (GO:0042364)3.27598742
82neurotransmitter-gated ion channel clustering (GO:0072578)3.27251922
83gas transport (GO:0015669)3.22227149
84regulation of cholesterol esterification (GO:0010872)3.21832515
85renal absorption (GO:0070293)3.19366718
86neuron projection regeneration (GO:0031102)3.16481987
87primary alcohol catabolic process (GO:0034310)3.14806060
88response to misfolded protein (GO:0051788)3.14381757
89regulation of cellular amide metabolic process (GO:0034248)3.11489492
90regulation of inclusion body assembly (GO:0090083)3.11013832
91positive regulation of hormone biosynthetic process (GO:0046886)3.09112266
92membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.07234521
93cerebellar granule cell differentiation (GO:0021707)3.06725314
94cellular response to cholesterol (GO:0071397)3.03154985
95cardiac left ventricle morphogenesis (GO:0003214)3.00109020
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99810588
97regulation of sodium ion transport (GO:0002028)2.98870104
98ionotropic glutamate receptor signaling pathway (GO:0035235)2.98740475
99axon ensheathment in central nervous system (GO:0032291)2.98590291
100central nervous system myelination (GO:0022010)2.98590291
101postsynaptic membrane organization (GO:0001941)2.98024990
102negative regulation of astrocyte differentiation (GO:0048712)2.96194384
103L-ascorbic acid metabolic process (GO:0019852)2.92198832
104omega-hydroxylase P450 pathway (GO:0097267)2.91001945
105negative regulation of myotube differentiation (GO:0010832)2.86793213
106regulation of heart rate by cardiac conduction (GO:0086091)2.86438008
107positive regulation of astrocyte differentiation (GO:0048711)2.86346846
108L-phenylalanine catabolic process (GO:0006559)2.84062077
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84062077
110cellular potassium ion homeostasis (GO:0030007)2.84025767
111negative regulation of blood vessel endothelial cell migration (GO:0043537)2.83133297
112chemical homeostasis within a tissue (GO:0048875)2.82431037
113trabecula morphogenesis (GO:0061383)2.81900537
114phospholipid efflux (GO:0033700)2.80491198
115venous blood vessel morphogenesis (GO:0048845)2.80153750
116cardiac ventricle formation (GO:0003211)2.79587079
117protein insertion into membrane (GO:0051205)2.79390996
118hydrogen peroxide metabolic process (GO:0042743)2.78610404
119short-chain fatty acid metabolic process (GO:0046459)2.78363566
120mechanosensory behavior (GO:0007638)2.77451754
121ovulation cycle (GO:0042698)2.76645251
122response to vitamin A (GO:0033189)2.75341856
123atrioventricular valve morphogenesis (GO:0003181)2.75178616
124water transport (GO:0006833)2.74823175
125bile acid biosynthetic process (GO:0006699)2.74354530
126regulation of extracellular matrix organization (GO:1903053)2.74012768
127relaxation of cardiac muscle (GO:0055119)2.73783076
128astrocyte development (GO:0014002)2.73579225
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72679902
130amino-acid betaine metabolic process (GO:0006577)2.72397183
131carnitine metabolic process (GO:0009437)2.71998819
132erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.71967208
133L-phenylalanine metabolic process (GO:0006558)2.71967208
134outer ear morphogenesis (GO:0042473)2.71259438
135regulation of glial cell proliferation (GO:0060251)2.71042652
136cell migration involved in heart development (GO:0060973)2.70658956
137negative regulation of myoblast differentiation (GO:0045662)2.69749559
138membrane repolarization during action potential (GO:0086011)2.67539092
139cardiac muscle cell proliferation (GO:0060038)2.67389156
140cAMP biosynthetic process (GO:0006171)2.67205547
141regulation of vasodilation (GO:0042312)2.65736830
142peripheral nervous system neuron development (GO:0048935)2.65543476
143response to gravity (GO:0009629)2.65398964
144cysteine metabolic process (GO:0006534)2.64047518
145positive regulation of steroid metabolic process (GO:0045940)2.62971095
146layer formation in cerebral cortex (GO:0021819)2.61800733
147high-density lipoprotein particle remodeling (GO:0034375)2.61785923
148positive regulation of steroid biosynthetic process (GO:0010893)2.60616185
149alpha-linolenic acid metabolic process (GO:0036109)2.58558150
150protein localization to endosome (GO:0036010)2.58376582
151camera-type eye morphogenesis (GO:0048593)2.55500729
152cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.55411421
153cardiac conduction (GO:0061337)2.53278976
154toxin metabolic process (GO:0009404)2.52643420
155regulation of steroid hormone biosynthetic process (GO:0090030)2.51273476
156cellular copper ion homeostasis (GO:0006878)2.50216909
157positive regulation of hormone metabolic process (GO:0032352)2.48331361
158peptidyl-glutamic acid carboxylation (GO:0017187)2.48307030
159protein carboxylation (GO:0018214)2.48307030
160negative regulation of sodium ion transport (GO:0010766)2.46925706
161negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.46038447
162regulation of fibrinolysis (GO:0051917)2.41984585
163fluid transport (GO:0042044)2.38254161
164regulation of cardioblast proliferation (GO:0003264)2.36041530
165regulation of secondary heart field cardioblast proliferation (GO:0003266)2.36041530
166pyrimidine nucleobase catabolic process (GO:0006208)2.35169915
167ectoderm development (GO:0007398)2.35009715
168fatty acid oxidation (GO:0019395)2.34999897
169reverse cholesterol transport (GO:0043691)2.34822158
170triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.33513453
171peptide biosynthetic process (GO:0043043)2.32766944
172calcium-mediated signaling using intracellular calcium source (GO:0035584)2.30085632
173lipid oxidation (GO:0034440)2.29882336
174sodium ion export (GO:0071436)2.29540396
175positive regulation of glycolytic process (GO:0045821)2.29111884
176negative regulation of microtubule polymerization (GO:0031115)2.28385264
177dopamine receptor signaling pathway (GO:0007212)2.28093499
178cell communication involved in cardiac conduction (GO:0086065)2.28073224
179CDP-diacylglycerol biosynthetic process (GO:0016024)2.26226653
180potassium ion homeostasis (GO:0055075)2.25036892
181behavioral response to cocaine (GO:0048148)2.23673265
182endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.22090353
183positive regulation of triglyceride biosynthetic process (GO:0010867)2.21740315
184* sensory perception of smell (GO:0007608)17.0149875
185positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr15.0154319
186tongue development (GO:0043586)13.9990758
187regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 13.1943579
188regulation of phospholipase A2 activity (GO:0032429)13.1735391
189chemosensory behavior (GO:0007635)12.5949113
190regulation of superoxide anion generation (GO:0032928)11.2096041
191response to phenylpropanoid (GO:0080184)10.2067472
192positive regulation of catenin import into nucleus (GO:0035413)10.1957285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.43921992
2ESR1_15608294_ChIP-ChIP_MCF-7_Human5.09883252
3AR_21572438_ChIP-Seq_LNCaP_Human4.56508224
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.23394517
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.81064064
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.80597997
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.52289889
8EGR1_19032775_ChIP-ChIP_M12_Human3.24930616
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.86937306
10PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.77817954
11DROSHA_22980978_ChIP-Seq_HELA_Human2.76588478
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.72177163
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.60396771
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.57154848
15ZNF263_19887448_ChIP-Seq_K562_Human2.46166055
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.40492235
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26810096
18CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.21334689
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19662683
20CLOCK_20551151_ChIP-Seq_293T_Human2.19287554
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18746624
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18670449
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08121137
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05673758
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.00757328
26LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90247608
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.80891386
28POU5F1_16518401_ChIP-PET_MESCs_Mouse1.80101349
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.74916477
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74187818
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74031222
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66713909
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65985373
34BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.65144416
35* ERG_21242973_ChIP-ChIP_JURKAT_Human1.64917771
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56790549
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54398824
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54073151
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53101233
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51861721
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51455646
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51455646
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50801179
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.48855592
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48423987
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47963022
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47893955
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.40634710
49KDM2B_26808549_Chip-Seq_K562_Human1.40499466
50TAF15_26573619_Chip-Seq_HEK293_Human1.38927574
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37991894
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37982721
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.37536215
54EZH2_22144423_ChIP-Seq_EOC_Human1.37105805
55GBX2_23144817_ChIP-Seq_PC3_Human1.36808326
56AHR_22903824_ChIP-Seq_MCF-7_Human1.35728695
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35186903
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33831213
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33406530
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.31721260
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30654765
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.30603864
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.30503188
64SMC4_20622854_ChIP-Seq_HELA_Human1.26197923
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24626136
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24513322
67TP53_23651856_ChIP-Seq_MEFs_Mouse1.24123754
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23907988
69RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23684321
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23135869
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23003707
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22201071
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.20897757
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19991348
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.19470778
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.19184596
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18811072
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18518725
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.17930844
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17783573
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16520960
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15249607
83ERG_20517297_ChIP-Seq_VCAP_Human1.15128639
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.14160984
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.13947613
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13874620
87SOX3_22085726_ChIP-Seq_NPCs_Mouse1.13801570
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.12343243
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11592327
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11559923
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11471342
92GATA1_22025678_ChIP-Seq_K562_Human1.11206674
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06507631
94MYC_19915707_ChIP-ChIP_AK7_Human1.06143922
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04080626
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02475327
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02289325
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01419077
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.01364338
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01162575
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00632327
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99698162
103SOX11_22085726_ChIP-Seq_ESNs_Mouse0.99681182
104RARB_27405468_Chip-Seq_BRAIN_Mouse0.99429113
105RING1B_27294783_Chip-Seq_NPCs_Mouse0.98169765
106EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97775545
107ISL1_27105846_Chip-Seq_CPCs_Mouse0.97479682
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96147156
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95826338
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95815809
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94304235
112ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94170633
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94134166
114JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93727399
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93549826
116LXR_22292898_ChIP-Seq_THP-1_Human0.93327950
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92745749
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92258674
119SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92119617
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92054060
121* GATA3_24758297_ChIP-Seq_MCF-7_Human0.92053088
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.91592474
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.90493188
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90124787
125REST_21632747_ChIP-Seq_MESCs_Mouse0.89941483
126SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87932671
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87524988
128RACK7_27058665_Chip-Seq_MCF-7_Human0.86219880
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85928085
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85917664
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.85712986
132KDM2B_26808549_Chip-Seq_JURKAT_Human0.85677774
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85229852
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84379411
135TCF7_22412390_ChIP-Seq_EML_Mouse0.84341988
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84277549
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84277549
138GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83434052
139NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82894637
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82866636
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82336669
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82314674
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82048764
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80918169
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80741337
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80405389
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80288564
148ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80178646
149TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79421202
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78333342
151TP63_22573176_ChIP-Seq_HFKS_Human0.78235995
152NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78132819
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.77208200
154SOX2_20726797_ChIP-Seq_SW620_Human0.76904244
155KLF5_25053715_ChIP-Seq_YYC3_Human0.76821614
156SMC1_22415368_ChIP-Seq_MEFs_Mouse0.76770972
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76744299
158MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.76677890
159NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76598519
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76358422
161KLF4_19829295_ChIP-Seq_ESCs_Human0.75200721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.06868396
2MP0005499_abnormal_olfactory_system5.98073953
3MP0005394_taste/olfaction_phenotype5.98073953
4MP0008789_abnormal_olfactory_epithelium4.54431815
5MP0000579_abnormal_nail_morphology4.49562947
6MP0000383_abnormal_hair_follicle3.93339660
7MP0002139_abnormal_hepatobiliary_system3.21393956
8MP0003806_abnormal_nucleotide_metabolis3.14120524
9MP0005365_abnormal_bile_salt2.60958807
10MP0010234_abnormal_vibrissa_follicle2.32825424
11MP0000467_abnormal_esophagus_morphology2.27316601
12MP0008775_abnormal_heart_ventricle2.07178200
13MP0000427_abnormal_hair_cycle2.05259086
14MP0009379_abnormal_foot_pigmentation16.0029467
15MP0001984_abnormal_olfaction12.4754258
16MP0005360_urolithiasis1.88640521
17MP0006138_congestive_heart_failure1.78194588
18MP0003136_yellow_coat_color1.68807016
19MP0002095_abnormal_skin_pigmentation1.67148265
20MP0010329_abnormal_lipoprotein_level1.60379592
21MP0005085_abnormal_gallbladder_physiolo1.56383015
22MP0010030_abnormal_orbit_morphology1.55160364
23MP0001177_atelectasis1.53667629
24MP0005646_abnormal_pituitary_gland1.49725583
25MP0002233_abnormal_nose_morphology1.45735334
26MP0002108_abnormal_muscle_morphology1.37192816
27MP0002098_abnormal_vibrissa_morphology1.33604258
28MP0003252_abnormal_bile_duct1.28526636
29MP0001346_abnormal_lacrimal_gland1.25835478
30MP0002060_abnormal_skin_morphology1.21318316
31MP0001485_abnormal_pinna_reflex1.21201192
32MP0003329_amyloid_beta_deposits1.21094461
33MP0002909_abnormal_adrenal_gland1.19117231
34MP0001881_abnormal_mammary_gland1.17659370
35MP0003091_abnormal_cell_migration1.14364126
36MP0005623_abnormal_meninges_morphology1.12732717
37MP0003075_altered_response_to1.09057274
38MP0003115_abnormal_respiratory_system1.08515007
39MP0001664_abnormal_digestion1.01267048
40MP0000604_amyloidosis1.01003064
41MP0002822_catalepsy0.99440944
42MP0001853_heart_inflammation0.96775565
43MP0002177_abnormal_outer_ear0.96446606
44MP0005584_abnormal_enzyme/coenzyme_acti0.92487231
45MP0000613_abnormal_salivary_gland0.92345563
46MP0002896_abnormal_bone_mineralization0.91995092
47MP0003195_calcinosis0.91128146
48MP0005197_abnormal_uvea_morphology0.88214422
49MP0004043_abnormal_pH_regulation0.88186125
50MP0000377_abnormal_hair_follicle0.86267441
51MP0003566_abnormal_cell_adhesion0.86017018
52MP0002697_abnormal_eye_size0.82674516
53MP0005058_abnormal_lysosome_morphology0.82658029
54MP0002653_abnormal_ependyma_morphology0.80245366
55MP0001340_abnormal_eyelid_morphology0.79949756
56MP0000516_abnormal_urinary_system0.78763540
57MP0005367_renal/urinary_system_phenotyp0.78763540
58MP0004381_abnormal_hair_follicle0.78269154
59MP0004858_abnormal_nervous_system0.77673691
60MP0002184_abnormal_innervation0.77408449
61MP0000609_abnormal_liver_physiology0.76905515
62MP0002118_abnormal_lipid_homeostasis0.74419203
63MP0004019_abnormal_vitamin_homeostasis0.74240296
64MP0000534_abnormal_ureter_morphology0.73789354
65MP0005379_endocrine/exocrine_gland_phen0.72133640
66MP0005391_vision/eye_phenotype0.68728369
67MP0005319_abnormal_enzyme/_coenzyme0.68193297
68MP0002877_abnormal_melanocyte_morpholog0.67942314
69MP0003300_gastrointestinal_ulcer0.67190923
70MP0001666_abnormal_nutrient_absorption0.66999551
71MP0005187_abnormal_penis_morphology0.66713642
72MP0005266_abnormal_metabolism0.66494058
73MP0005670_abnormal_white_adipose0.66343324
74MP0001502_abnormal_circadian_rhythm0.66313429
75MP0003632_abnormal_nervous_system0.65712498
76MP0003705_abnormal_hypodermis_morpholog0.64245997
77MP0004859_abnormal_synaptic_plasticity0.64163132
78MP0006054_spinal_hemorrhage0.63713315
79MP0009780_abnormal_chondrocyte_physiolo0.63705340
80MP0009643_abnormal_urine_homeostasis0.63246586
81MP0003690_abnormal_glial_cell0.62832634
82MP0005388_respiratory_system_phenotype0.59475617
83MP0002133_abnormal_respiratory_system0.59475617
84MP0002063_abnormal_learning/memory/cond0.59137934
85MP0003633_abnormal_nervous_system0.58923202
86MP0005248_abnormal_Harderian_gland0.58157531
87MP0000465_gastrointestinal_hemorrhage0.57283789
88MP0001299_abnormal_eye_distance/0.57262859
89MP0003635_abnormal_synaptic_transmissio0.56835983
90MP0003942_abnormal_urinary_system0.56042270
91MP0002249_abnormal_larynx_morphology0.55399664
92MP0001542_abnormal_bone_strength0.55364626
93MP0004270_analgesia0.55210375
94MP0003938_abnormal_ear_development0.54473305
95MP0001849_ear_inflammation0.53182300
96MP0002970_abnormal_white_adipose0.50818753
97MP0003656_abnormal_erythrocyte_physiolo0.50145459
98MP0003303_peritoneal_inflammation0.49850800
99MP0002837_dystrophic_cardiac_calcinosis0.49642352
100MP0002752_abnormal_somatic_nervous0.49591120
101MP0009840_abnormal_foam_cell0.49211723
102MP0008874_decreased_physiological_sensi0.48596741
103MP0000230_abnormal_systemic_arterial0.48242605
104MP0009384_cardiac_valve_regurgitation0.48201687
105MP0005167_abnormal_blood-brain_barrier0.48069930
106MP0003283_abnormal_digestive_organ0.45663390
107MP0002882_abnormal_neuron_morphology0.45613160
108MP0001286_abnormal_eye_development0.45459881
109MP0005332_abnormal_amino_acid0.44741868
110MP0004130_abnormal_muscle_cell0.44191777
111MP0002282_abnormal_trachea_morphology0.43706288
112MP0004085_abnormal_heartbeat0.43410393
113MP0003755_abnormal_palate_morphology0.42648312
114MP0005508_abnormal_skeleton_morphology0.42208259
115MP0004885_abnormal_endolymph0.42201418
116MP0002928_abnormal_bile_duct0.42066061
117MP0000026_abnormal_inner_ear0.41939672
118MP0003186_abnormal_redox_activity0.41921642
119MP0009745_abnormal_behavioral_response0.41886831
120MP0005253_abnormal_eye_physiology0.41763087
121MP0000647_abnormal_sebaceous_gland0.41447122
122MP0002295_abnormal_pulmonary_circulatio0.41033275
123MP0005166_decreased_susceptibility_to0.40829479
124MP0004134_abnormal_chest_morphology0.40592055
125MP0008569_lethality_at_weaning0.39743671
126MP0009764_decreased_sensitivity_to0.39622417
127MP0004185_abnormal_adipocyte_glucose0.39603320
128MP0006276_abnormal_autonomic_nervous0.39589589
129MP0010678_abnormal_skin_adnexa0.38679538
130MP0005310_abnormal_salivary_gland0.38657976
131MP0001486_abnormal_startle_reflex0.38555680
132MP0000920_abnormal_myelination0.37883512
133MP0003935_abnormal_craniofacial_develop0.37861622
134MP0002092_abnormal_eye_morphology0.37581686
135MP0009053_abnormal_anal_canal0.37140280
136MP0004957_abnormal_blastocyst_morpholog0.36837699
137MP0000762_abnormal_tongue_morphology0.36813013
138MP0000778_abnormal_nervous_system0.36628032
139MP0003279_aneurysm0.35780675
140MP0001915_intracranial_hemorrhage0.35426113
141MP0002152_abnormal_brain_morphology0.35284566
142MP0002734_abnormal_mechanical_nocicepti0.35088321
143MP0003631_nervous_system_phenotype0.34841539
144MP0002009_preneoplasia0.34236463
145MP0000598_abnormal_liver_morphology0.34154797
146MP0003634_abnormal_glial_cell0.33975568
147MP0003183_abnormal_peptide_metabolism0.33079461
148MP0002064_seizures0.32923382
149MP0005645_abnormal_hypothalamus_physiol0.32625007
150MP0005376_homeostasis/metabolism_phenot0.31872761
151MP0001944_abnormal_pancreas_morphology0.31627316
152MP0000049_abnormal_middle_ear0.31391187
153MP0005220_abnormal_exocrine_pancreas0.31224896
154MP0008961_abnormal_basal_metabolism0.31136651
155MP0004197_abnormal_fetal_growth/weight/0.30735074
156MP0002116_abnormal_craniofacial_bone0.30134009
157MP0001905_abnormal_dopamine_level0.29503904
158MP0005595_abnormal_vascular_smooth0.29248636
159MP0000163_abnormal_cartilage_morphology0.28790513
160MP0000432_abnormal_head_morphology0.28039891
161MP0001216_abnormal_epidermal_layer0.26803499
162MP0005409_darkened_coat_color0.24706807
163MP0005193_abnormal_anterior_eye0.24625856
164MP0003861_abnormal_nervous_system0.24575944
165MP0001191_abnormal_skin_condition0.23113567
166MP0001963_abnormal_hearing_physiology0.22336955

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)5.72126834
2Elfin facies (HP:0004428)5.59784770
3Overriding aorta (HP:0002623)5.53220059
4Abnormality of dentin (HP:0010299)5.14425447
5Bilateral sensorineural hearing impairment (HP:0008619)5.09482689
6Ulnar bowing (HP:0003031)4.93586077
7Obstructive sleep apnea (HP:0002870)4.84143634
8Abnormality of the diencephalon (HP:0010662)4.81393728
9Renovascular hypertension (HP:0100817)4.77530736
10Split foot (HP:0001839)4.72204397
11Insomnia (HP:0100785)4.61913961
12Decreased circulating renin level (HP:0003351)4.59790629
13Renal duplication (HP:0000075)4.42980540
14Flat cornea (HP:0007720)4.29352427
15Neoplasm of the lung (HP:0100526)4.22761915
16Mesangial abnormality (HP:0001966)4.19499796
17Bifid scrotum (HP:0000048)4.07190699
18Atrioventricular block (HP:0001678)3.96871552
19Humeroradial synostosis (HP:0003041)3.83602119
20Synostosis involving the elbow (HP:0003938)3.83602119
21Palpitations (HP:0001962)3.83493562
22Bronchomalacia (HP:0002780)3.82924259
23Neoplasm of the respiratory system (HP:0100606)3.71950179
24Deep venous thrombosis (HP:0002625)3.60664607
25Missing ribs (HP:0000921)3.60606936
26Urethral obstruction (HP:0000796)3.51958196
27Limb dystonia (HP:0002451)3.36928455
28Syncope (HP:0001279)3.28708224
29Megalocornea (HP:0000485)3.28113995
30Prolonged QT interval (HP:0001657)3.20045995
31Bladder diverticulum (HP:0000015)3.13114484
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.09906012
33Xanthomatosis (HP:0000991)3.04907577
34Abnormality of the right ventricle (HP:0001707)3.00848379
35Partial duplication of thumb phalanx (HP:0009944)3.00376911
36Torticollis (HP:0000473)2.99422438
37Bowing of the arm (HP:0006488)2.94780191
38Bowed forearm bones (HP:0003956)2.94780191
39Shallow orbits (HP:0000586)2.92164578
40Increased nuchal translucency (HP:0010880)2.91573192
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.91568943
42Poikilocytosis (HP:0004447)2.90867855
43Abnormality of the axillary hair (HP:0100134)2.89309853
44Abnormality of secondary sexual hair (HP:0009888)2.89309853
45Intrahepatic cholestasis (HP:0001406)2.81508627
46Intestinal atresia (HP:0011100)2.80370031
47Increased circulating renin level (HP:0000848)2.78073060
48Dysphonia (HP:0001618)2.77279584
49Femoral bowing (HP:0002980)2.75697668
50Complement deficiency (HP:0004431)2.73308112
51Abnormality of sodium homeostasis (HP:0010931)2.72242230
52Late onset (HP:0003584)2.70572438
53Craniofacial dystonia (HP:0012179)2.69901923
54Lip pit (HP:0100267)2.69613628
55Choanal stenosis (HP:0000452)2.68782962
56Protrusio acetabuli (HP:0003179)2.64270277
57Partial duplication of the phalanx of hand (HP:0009999)2.60888946
58Patellar dislocation (HP:0002999)2.58619946
59Absent hand (HP:0004050)2.57518744
60Hyperlipoproteinemia (HP:0010980)2.57019977
61Hypobetalipoproteinemia (HP:0003563)2.56872107
62Vaginal fistula (HP:0004320)2.55744743
63Ketoacidosis (HP:0001993)2.55535421
64Atonic seizures (HP:0010819)2.55457089
65Hypercalcemia (HP:0003072)2.53821345
66Heart block (HP:0012722)2.53382040
67Adactyly (HP:0009776)2.52755926
68Turricephaly (HP:0000262)2.51471167
69Bowel diverticulosis (HP:0005222)2.50913481
7011 pairs of ribs (HP:0000878)2.49267332
71Focal dystonia (HP:0004373)2.48732428
72Aplasia cutis congenita (HP:0001057)2.48454886
73Hyperaldosteronism (HP:0000859)2.46048740
74Abnormality of renin-angiotensin system (HP:0000847)2.45382033
75Hyperglycinemia (HP:0002154)2.45342778
76Labial hypoplasia (HP:0000066)2.44478327
77Ketosis (HP:0001946)2.43227761
78Delayed CNS myelination (HP:0002188)2.40964501
79Polycythemia (HP:0001901)2.39416048
80Abnormal atrioventricular conduction (HP:0005150)2.36680183
81Posterior embryotoxon (HP:0000627)2.35055224
82Abnormal EKG (HP:0003115)2.30480241
83Bowel incontinence (HP:0002607)2.29676760
84Abnormality of serine family amino acid metabolism (HP:0010894)2.29656840
85Abnormality of glycine metabolism (HP:0010895)2.29656840
86Tinnitus (HP:0000360)2.24981499
87Arterial tortuosity (HP:0005116)2.24929340
88Gastrointestinal atresia (HP:0002589)2.24230610
89Hyperparathyroidism (HP:0000843)2.23891860
90Laryngomalacia (HP:0001601)2.23813763
91Hyperglycinuria (HP:0003108)2.23803468
92Retinal dysplasia (HP:0007973)2.22874010
93Abnormality of the line of Schwalbe (HP:0008048)2.21345008
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.19662694
95Anosmia (HP:0000458)2.18161649
96Rectal fistula (HP:0100590)2.15185101
97Rectovaginal fistula (HP:0000143)2.15185101
98Cerebral inclusion bodies (HP:0100314)2.14960609
99Hypochromic microcytic anemia (HP:0004840)2.14548740
100Peripheral hypomyelination (HP:0007182)2.14340542
101Pointed chin (HP:0000307)2.12195443
102Hypothermia (HP:0002045)2.11968904
103Abnormality of the dental pulp (HP:0006479)2.11876411
104Sleep apnea (HP:0010535)2.10683769
105Abnormal large intestine physiology (HP:0012700)2.10448796
106Muscle fiber splitting (HP:0003555)2.10327227
107Broad metatarsal (HP:0001783)2.08659500
108Glossoptosis (HP:0000162)2.08622569
109Abnormality of the common coagulation pathway (HP:0010990)2.08565990
110Hypolipoproteinemia (HP:0010981)2.08193848
111Abnormally folded helix (HP:0008544)2.06683168
112Hypoplastic female external genitalia (HP:0012815)2.06637714
113Abnormality of macular pigmentation (HP:0008002)2.04601279
114Spastic diplegia (HP:0001264)2.04481951
115Primary atrial arrhythmia (HP:0001692)2.04240409
116Absent toe (HP:0010760)2.04139873
117Wormian bones (HP:0002645)2.03926726
118Overfolded helix (HP:0000396)2.03867837
119Amyloidosis (HP:0011034)2.01866060
120Abnormality of cochlea (HP:0000375)2.01608068
121Vascular tortuosity (HP:0004948)2.01299798
122Alveolar cell carcinoma (HP:0006519)11.3563574
123Neoplasm of the tracheobronchial system (HP:0100552)10.4587698
124Overgrowth (HP:0001548)1.99966047
125Renal tubular acidosis (HP:0001947)1.99080143
126Hypoalphalipoproteinemia (HP:0003233)1.98350700
127Genetic anticipation (HP:0003743)1.97602569
128Right ventricular cardiomyopathy (HP:0011663)1.97545175
129Obsessive-compulsive behavior (HP:0000722)1.96521582
130Mutism (HP:0002300)1.96196433
131Hypercholesterolemia (HP:0003124)1.95139720
132Intestinal fistula (HP:0100819)1.93675877
133Hypercalciuria (HP:0002150)1.93479123
134Atrial fibrillation (HP:0005110)1.93120240
135Hypoplasia of the odontoid process (HP:0003311)1.92266102
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91870985
137Arnold-Chiari malformation (HP:0002308)1.90800447
138Supraventricular tachycardia (HP:0004755)1.89729774
139Renal dysplasia (HP:0000110)1.89494016
140Abnormality of complement system (HP:0005339)1.89388778
141Hallux valgus (HP:0001822)1.89186402
142Adducted thumb (HP:0001181)1.88690305
143Prolonged partial thromboplastin time (HP:0003645)1.87822694
144Abnormal drinking behavior (HP:0030082)1.85894190
145Polydipsia (HP:0001959)1.85894190
146Precocious puberty (HP:0000826)1.85481213
147Supraventricular arrhythmia (HP:0005115)1.85427153
148Hyperammonemia (HP:0001987)1.85352010
149Anterior segment dysgenesis (HP:0007700)1.84237262
150Cerebral aneurysm (HP:0004944)1.82905343
151Neurofibrillary tangles (HP:0002185)1.81478260
152Hypokalemia (HP:0002900)1.79761616
153Neonatal onset (HP:0003623)1.79679143
154Spina bifida occulta (HP:0003298)1.79485199
155Hepatocellular carcinoma (HP:0001402)1.78121383
156Abnormality of the odontoid process (HP:0003310)1.76637788
157Polar cataract (HP:0010696)1.74854511
158Abnormal cartilage morphology (HP:0002763)1.74674278
159Pulmonary embolism (HP:0002204)1.74296264
160Abnormality of the gastric mucosa (HP:0004295)1.73957817
161Fat malabsorption (HP:0002630)1.73472943
162Abnormal ciliary motility (HP:0012262)1.72703551
163Deviation of the hallux (HP:0010051)1.71860753
164Tarsal synostosis (HP:0008368)1.71286490
165Back pain (HP:0003418)1.70964034
166Epidermoid cyst (HP:0200040)1.70643997
167Esophageal varix (HP:0002040)1.69045733
168Polycystic kidney dysplasia (HP:0000113)1.68904527
169Abnormal respiratory motile cilium physiology (HP:0012261)1.68759310
170Periauricular skin pits (HP:0100277)1.68237850
171Preauricular pit (HP:0004467)1.68237850
172Morphological abnormality of the inner ear (HP:0011390)1.67371573
173Germ cell neoplasia (HP:0100728)1.66041261
174Periorbital edema (HP:0100539)1.65039698
175Bradycardia (HP:0001662)1.64861971
176Megalencephaly (HP:0001355)1.64260213
177Biliary tract neoplasm (HP:0100574)1.64252832
178Oligodactyly (hands) (HP:0001180)1.64005412
179Mitral valve prolapse (HP:0001634)1.62833692
180Portal hypertension (HP:0001409)1.62627548
181Osteolytic defects of the hand bones (HP:0009699)1.62441163
182Osteolytic defects of the phalanges of the hand (HP:0009771)1.62441163
183Death in childhood (HP:0003819)1.62275161
184Pulmonary artery stenosis (HP:0004415)1.60914783
185Abnormality of the endocardium (HP:0004306)1.60454174
186Generalized tonic-clonic seizures (HP:0002069)1.60250543
187Facial edema (HP:0000282)1.59860523
188Abnormal glucose tolerance (HP:0001952)1.59854746
189Hypercortisolism (HP:0001578)1.59841159
190Metabolic alkalosis (HP:0200114)1.59818610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN15.83080450
2MAPK114.03993441
3MAPK153.11676249
4SIK12.95697241
5RIPK12.87412300
6PAK32.85687307
7TYRO32.82574887
8LATS12.42324154
9STK392.39296770
10TRIB32.24558285
11CAMK2D2.07317240
12FRK2.06808332
13ERBB31.99067862
14DAPK21.98864408
15TGFBR21.95503160
16CAMK2B1.94432379
17SIK21.88845344
18HIPK21.88555296
19JAK21.85855322
20CSNK1A1L1.83009434
21NEK11.76562701
22LMTK21.75546692
23MAP3K21.75215686
24ERN11.68778847
25PKN21.68236594
26EEF2K1.62943957
27CAMK2G1.50598960
28MAP3K71.48719651
29DDR21.45849972
30FER1.44222523
31MAP2K41.44091173
32NTRK11.38390921
33MST1R1.36681678
34FGFR21.34286805
35CSNK1G21.31893436
36CSNK1G11.27715981
37GRK61.26800355
38PAK61.23091275
39CSNK1G31.17388084
40SCYL21.17013834
41BCKDK1.16482122
42MAP3K41.13597623
43INSRR1.11965333
44MAPKAPK31.11911023
45EPHB11.03920212
46NTRK21.03178444
47CDK61.02292475
48TESK11.01218187
49NTRK30.99772015
50OXSR10.99767065
51MAP2K10.94266463
52PDGFRA0.89752620
53ALK0.86358893
54PRKCG0.86328273
55PTK60.86203213
56EGFR0.84160525
57KSR20.83535350
58NEK60.82346712
59PRKD10.81724587
60PDK30.81659359
61PDK40.81659359
62MINK10.81534087
63TTN0.74182988
64PDPK10.72956522
65WNK40.71587595
66ERBB20.69625739
67PRKCH0.67752783
68ERBB40.67427964
69FGFR40.65618727
70STK240.64838270
71TTK0.63791528
72CAMKK10.63168792
73PRKG20.63071375
74RET0.62554297
75LRRK20.61745374
76DYRK1B0.59883564
77CAMK2A0.59882104
78TRPM70.59881337
79MET0.59459601
80CDK50.57729570
81ITK0.56551924
82ROCK20.55132543
83FYN0.54953915
84CSK0.54603632
85BMX0.53760469
86PAK20.50464483
87MAP3K100.50365207
88STK38L0.50063223
89ABL10.49209729
90PHKG20.48373399
91PHKG10.48373399
92RPS6KB20.47248822
93PTK20.46739974
94ICK0.46216524
95STK30.44933227
96WNK10.44450315
97PDK20.44145346
98FGFR30.43002865
99MARK10.42978787
100EPHA30.42324554
101JAK10.41990933
102PRKD30.41132619
103PRKACG0.40814911
104FES0.40522144
105PRKCD0.39785425
106NUAK10.38778942
107FGFR10.37672194
108PRKCZ0.37473983
109LIMK10.36759349
110DYRK20.36461489
111TYK20.34416345
112MAPK100.34247556
113TAOK10.33692715
114CSNK1E0.33571799
115ROCK10.31903093
116SMG10.31891737
117MARK20.30593270
118SGK20.29699432
119SIK30.29063967
120DYRK1A0.27113441
121UHMK10.27037239
122BLK0.26898266
123MAPK30.25988931
124SRC0.25222584
125MKNK20.24684696
126PDGFRB0.24580583
127RPS6KA50.22952615
128STK380.20581787
129SGK30.20485893
130PRKD20.19643444
131PRKDC0.19271886
132NME10.18759623
133PRKCB0.18578337
134CSF1R0.18509719
135SGK4940.18115817
136SGK2230.18115817
137MAPK120.17343085
138MAPK10.16996822
139PBK0.16740509
140SRPK10.15201512
141CDK30.14064714
142MTOR0.10885711
143MAPKAPK20.10872518
144MAPK140.10638149
145MAPK80.10474400
146CDK20.10309792
147IRAK10.10057631
148KIT0.08370970
149ABL20.08345384
150SGK10.08125181
151CSNK2A20.07960239
152FGR0.07665446
153CDK90.07544643
154PRKG10.07242216
155JAK30.06796457
156CLK10.06076123

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043207.79231179
2Olfactory transduction_Homo sapiens_hsa047405.22360643
3Bladder cancer_Homo sapiens_hsa052193.86716440
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.63291158
5Endometrial cancer_Homo sapiens_hsa052133.56353847
6Non-small cell lung cancer_Homo sapiens_hsa052233.48097743
7Notch signaling pathway_Homo sapiens_hsa043303.32993683
8Pentose and glucuronate interconversions_Homo sapiens_hsa000403.15049131
9Caffeine metabolism_Homo sapiens_hsa002322.99855885
10Glioma_Homo sapiens_hsa052142.95451538
11Pancreatic cancer_Homo sapiens_hsa052122.87273921
12Glutathione metabolism_Homo sapiens_hsa004802.85665025
13Butanoate metabolism_Homo sapiens_hsa006502.72453288
14Thyroid hormone synthesis_Homo sapiens_hsa049182.46170537
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29462925
16Melanoma_Homo sapiens_hsa052182.22097204
17Central carbon metabolism in cancer_Homo sapiens_hsa052302.13110811
18Cyanoamino acid metabolism_Homo sapiens_hsa004602.09248844
19ErbB signaling pathway_Homo sapiens_hsa040122.08911129
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.04158433
21Choline metabolism in cancer_Homo sapiens_hsa052312.00990416
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00127181
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.96651290
24Nitrogen metabolism_Homo sapiens_hsa009101.95186175
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.93031850
26Bile secretion_Homo sapiens_hsa049761.88038008
27Histidine metabolism_Homo sapiens_hsa003401.86265861
28Sulfur metabolism_Homo sapiens_hsa009201.83737906
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.82765249
30beta-Alanine metabolism_Homo sapiens_hsa004101.82494545
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70740020
32Prostate cancer_Homo sapiens_hsa052151.68162709
33Arachidonic acid metabolism_Homo sapiens_hsa005901.66299431
34Chemical carcinogenesis_Homo sapiens_hsa052041.55859996
35MicroRNAs in cancer_Homo sapiens_hsa052061.49169486
36Fatty acid degradation_Homo sapiens_hsa000711.46231160
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44922186
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44106317
39Tryptophan metabolism_Homo sapiens_hsa003801.42724924
40Hepatitis C_Homo sapiens_hsa051601.42278045
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38117156
42Salivary secretion_Homo sapiens_hsa049701.37146530
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.34647717
44HIF-1 signaling pathway_Homo sapiens_hsa040661.34182804
45Retinol metabolism_Homo sapiens_hsa008301.28870281
46Arginine biosynthesis_Homo sapiens_hsa002201.28848311
47FoxO signaling pathway_Homo sapiens_hsa040681.27584109
48Propanoate metabolism_Homo sapiens_hsa006401.25335345
49Vibrio cholerae infection_Homo sapiens_hsa051101.22849990
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21292700
51Starch and sucrose metabolism_Homo sapiens_hsa005001.20231585
52Other glycan degradation_Homo sapiens_hsa005111.16439270
53ABC transporters_Homo sapiens_hsa020101.15096854
54Pyruvate metabolism_Homo sapiens_hsa006201.06368180
55Gastric acid secretion_Homo sapiens_hsa049711.01530375
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98185746
57Ras signaling pathway_Homo sapiens_hsa040140.97831038
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94890597
59Rap1 signaling pathway_Homo sapiens_hsa040150.94485502
60Focal adhesion_Homo sapiens_hsa045100.88772188
61Complement and coagulation cascades_Homo sapiens_hsa046100.85318168
62Morphine addiction_Homo sapiens_hsa050320.81946930
63Collecting duct acid secretion_Homo sapiens_hsa049660.81914488
64Insulin secretion_Homo sapiens_hsa049110.81581260
65PPAR signaling pathway_Homo sapiens_hsa033200.80868041
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79843092
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78538199
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77384656
69Circadian entrainment_Homo sapiens_hsa047130.75474809
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73532873
71Dopaminergic synapse_Homo sapiens_hsa047280.73485667
72GABAergic synapse_Homo sapiens_hsa047270.71593160
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69588693
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68762499
75Fatty acid metabolism_Homo sapiens_hsa012120.67419387
76Proteoglycans in cancer_Homo sapiens_hsa052050.67327614
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66543434
78Endocytosis_Homo sapiens_hsa041440.66499548
79Phenylalanine metabolism_Homo sapiens_hsa003600.66450769
80Estrogen signaling pathway_Homo sapiens_hsa049150.66114853
81Cocaine addiction_Homo sapiens_hsa050300.65143330
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64643389
83Synaptic vesicle cycle_Homo sapiens_hsa047210.63936996
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63655732
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62992295
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61234229
87Lysine degradation_Homo sapiens_hsa003100.61192337
88Selenocompound metabolism_Homo sapiens_hsa004500.60951342
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60905656
90cAMP signaling pathway_Homo sapiens_hsa040240.56368761
91Peroxisome_Homo sapiens_hsa041460.53910111
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.53283268
93Ovarian steroidogenesis_Homo sapiens_hsa049130.50252706
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49669861
95Fatty acid biosynthesis_Homo sapiens_hsa000610.49408885
96Chronic myeloid leukemia_Homo sapiens_hsa052200.49161319
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48817691
98MAPK signaling pathway_Homo sapiens_hsa040100.48313339
99Arginine and proline metabolism_Homo sapiens_hsa003300.46546955
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.45530377
101Tyrosine metabolism_Homo sapiens_hsa003500.45462705
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45212758
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44517126
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43581585
105GnRH signaling pathway_Homo sapiens_hsa049120.42087254
106Glutamatergic synapse_Homo sapiens_hsa047240.41911663
107Pathways in cancer_Homo sapiens_hsa052000.41741197
108Cholinergic synapse_Homo sapiens_hsa047250.41269469
109Insulin resistance_Homo sapiens_hsa049310.40039225
110Sulfur relay system_Homo sapiens_hsa041220.39574458
111Renin secretion_Homo sapiens_hsa049240.39479622
112Taste transduction_Homo sapiens_hsa047420.38766556
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37151172
114Inositol phosphate metabolism_Homo sapiens_hsa005620.36968686
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.35650525
116Axon guidance_Homo sapiens_hsa043600.35582305
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35414891
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34804213
119Carbon metabolism_Homo sapiens_hsa012000.33945738
120Pancreatic secretion_Homo sapiens_hsa049720.33064575
121mRNA surveillance pathway_Homo sapiens_hsa030150.32862132
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32048828
123Melanogenesis_Homo sapiens_hsa049160.31770851
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31230519
125Dilated cardiomyopathy_Homo sapiens_hsa054140.31145496
126ECM-receptor interaction_Homo sapiens_hsa045120.30696298
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30599207
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30302264
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29870504
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28668003
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.28665239
132Amphetamine addiction_Homo sapiens_hsa050310.27750718
133Adherens junction_Homo sapiens_hsa045200.27468374
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27296698
135VEGF signaling pathway_Homo sapiens_hsa043700.27099792
136Amoebiasis_Homo sapiens_hsa051460.27090341
137Prion diseases_Homo sapiens_hsa050200.25342783
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23930716
139Type II diabetes mellitus_Homo sapiens_hsa049300.23243428
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23045052
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22914511
142Oxytocin signaling pathway_Homo sapiens_hsa049210.22758116
143Staphylococcus aureus infection_Homo sapiens_hsa051500.22514352
144Circadian rhythm_Homo sapiens_hsa047100.22273705
145Gap junction_Homo sapiens_hsa045400.20992470
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.20968275
147Lysosome_Homo sapiens_hsa041420.19657924
148Calcium signaling pathway_Homo sapiens_hsa040200.18929725
149Colorectal cancer_Homo sapiens_hsa052100.18797940
150Prolactin signaling pathway_Homo sapiens_hsa049170.16184168
151Renal cell carcinoma_Homo sapiens_hsa052110.11184863
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10885792
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.10527907
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08446217
155AMPK signaling pathway_Homo sapiens_hsa041520.08312075

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