OBSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytoskeletal adaptor proteins function in linking the internal cytoskeleton of cells to the cell membrane. This gene encodes a cytoskeletal adaptor protein, which is a member of the Unc-89/obscurin family. The protein contains multiple N- and C-terminal immunoglobulin (Ig)-like domains and a central fibronectin type 3 domain. Mutations in this gene cause 3M syndrome type 2. Alternatively spliced transcript variants encoding different isoforms have been found in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)6.87626083
2sarcomere organization (GO:0045214)5.82862796
3* cardiac myofibril assembly (GO:0055003)5.81293258
4plasma membrane repair (GO:0001778)5.50723176
5actin-myosin filament sliding (GO:0033275)5.17998874
6muscle filament sliding (GO:0030049)5.17998874
7negative regulation of potassium ion transmembrane transport (GO:1901380)4.98045093
8* myofibril assembly (GO:0030239)4.84984042
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.83725622
10actin-mediated cell contraction (GO:0070252)4.35774751
11cardiac muscle cell development (GO:0055013)4.26700569
12protein heterotrimerization (GO:0070208)4.07956434
13* actomyosin structure organization (GO:0031032)4.07155883
14regulation of cardioblast differentiation (GO:0051890)4.05512322
15cardiac muscle contraction (GO:0060048)4.03393240
16cardiac cell development (GO:0055006)4.02536749
17paraxial mesoderm development (GO:0048339)4.00647925
18regulation of skeletal muscle contraction (GO:0014819)3.95461462
19heart trabecula formation (GO:0060347)3.76046690
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.71517891
21positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.70976702
22regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.65331777
23adult heart development (GO:0007512)3.54909883
24actin filament-based movement (GO:0030048)3.45724053
25ventricular cardiac muscle cell action potential (GO:0086005)3.44938418
26atrial septum morphogenesis (GO:0060413)3.44502320
27cardiac muscle tissue morphogenesis (GO:0055008)3.44140507
28ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.43195772
29regulation of sarcomere organization (GO:0060297)3.35240530
30regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.34820788
31positive regulation of male gonad development (GO:2000020)3.34776177
32planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34603772
33polarized epithelial cell differentiation (GO:0030859)3.31276412
34basement membrane organization (GO:0071711)3.31155049
35bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30224380
36trabecula formation (GO:0060343)3.29821861
37regulation of actin filament-based movement (GO:1903115)3.29325531
38negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.28204229
39striated muscle contraction (GO:0006941)3.27864059
40cardiac muscle hypertrophy (GO:0003300)3.26698608
41epithelial cell-cell adhesion (GO:0090136)3.25358670
42muscle tissue morphogenesis (GO:0060415)3.19985964
43outflow tract septum morphogenesis (GO:0003148)3.19695147
44anatomical structure regression (GO:0060033)3.15782825
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14683563
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.14402557
47endocardial cushion development (GO:0003197)3.12736003
48convergent extension (GO:0060026)3.12114843
49hippo signaling (GO:0035329)3.11389643
50negative regulation of striated muscle cell apoptotic process (GO:0010664)3.10345421
51striated muscle hypertrophy (GO:0014897)3.09768733
52regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.07620285
53ventricular cardiac muscle cell development (GO:0055015)3.07166003
54embryonic foregut morphogenesis (GO:0048617)3.06325492
55heart morphogenesis (GO:0003007)3.05748231
56cell communication by electrical coupling (GO:0010644)3.05616076
57negative regulation of cell size (GO:0045792)3.03497184
58insulin-like growth factor receptor signaling pathway (GO:0048009)3.02685528
59cell-cell junction maintenance (GO:0045217)2.99397581
60lung epithelium development (GO:0060428)2.96901981
61bone trabecula formation (GO:0060346)2.95421564
62regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94224872
63negative regulation of catenin import into nucleus (GO:0035414)2.93738899
64positive regulation of myotube differentiation (GO:0010831)2.93316004
65glomerular basement membrane development (GO:0032836)2.92687872
66muscle cell fate commitment (GO:0042693)2.91268584
67sex determination (GO:0007530)2.91227550
68regulation of male gonad development (GO:2000018)2.89163057
69endothelial cell chemotaxis (GO:0035767)2.86446049
70mesenchyme development (GO:0060485)2.85296133
71camera-type eye morphogenesis (GO:0048593)2.83505703
72growth hormone secretion (GO:0030252)2.83159166
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.82208324
74embryonic retina morphogenesis in camera-type eye (GO:0060059)2.82051958
75cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.78909812
76adherens junction assembly (GO:0034333)2.78432416
77tricarboxylic acid cycle (GO:0006099)2.78052206
78regulation of membrane repolarization (GO:0060306)2.77999115
79cardiac muscle cell proliferation (GO:0060038)2.77170419
80cell communication involved in cardiac conduction (GO:0086065)2.75159352
81semaphorin-plexin signaling pathway (GO:0071526)2.74408732
82regulation of heart morphogenesis (GO:2000826)2.74266026
83establishment of apical/basal cell polarity (GO:0035089)2.73847619
84regulation of striated muscle contraction (GO:0006942)2.73437569
85collagen fibril organization (GO:0030199)2.71888466
86branching involved in salivary gland morphogenesis (GO:0060445)2.71179910
87cell migration involved in heart development (GO:0060973)2.70195410
88cardiac muscle hypertrophy in response to stress (GO:0014898)2.70151039
89muscle hypertrophy in response to stress (GO:0003299)2.70151039
90cardiac muscle adaptation (GO:0014887)2.70151039
91cell junction maintenance (GO:0034331)2.67913196
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.66989344
93atrioventricular valve morphogenesis (GO:0003181)2.66432571
94regulation of establishment of planar polarity (GO:0090175)2.64428870
95protein hydroxylation (GO:0018126)2.62589012
96striated muscle cell development (GO:0055002)2.62170217
97regulation of tight junction assembly (GO:2000810)2.60801626
98muscle hypertrophy (GO:0014896)2.60423533
99regulation of cardioblast proliferation (GO:0003264)2.59677208
100regulation of secondary heart field cardioblast proliferation (GO:0003266)2.59677208
101notochord development (GO:0030903)2.59488155
102metanephric mesenchyme development (GO:0072075)2.59264113
103axon extension involved in axon guidance (GO:0048846)2.59099853
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.59099853
105gastrulation with mouth forming second (GO:0001702)2.58522403
106postsynaptic membrane organization (GO:0001941)2.57515319
107peptidyl-lysine dimethylation (GO:0018027)2.56759511
108regulation of cholesterol biosynthetic process (GO:0045540)2.55255095
109negative regulation of potassium ion transport (GO:0043267)2.53278704
110response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.52751275
111positive regulation of glycogen biosynthetic process (GO:0045725)2.52523168
112non-canonical Wnt signaling pathway (GO:0035567)2.52311792
113regulation of the force of heart contraction (GO:0002026)2.51436818
114peripheral nervous system axon ensheathment (GO:0032292)2.51421049
115myelination in peripheral nervous system (GO:0022011)2.51421049
116outer ear morphogenesis (GO:0042473)2.47939091
117myoblast fusion (GO:0007520)2.47806276
118cardiac muscle tissue development (GO:0048738)2.47447989
119cell migration in hindbrain (GO:0021535)2.47335597
120cell-substrate adherens junction assembly (GO:0007045)2.46577766
121focal adhesion assembly (GO:0048041)2.46577766
122muscle cell development (GO:0055001)2.45805699
123protein retention in ER lumen (GO:0006621)2.43973080
124G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.41458803
125regulation of axon extension involved in axon guidance (GO:0048841)2.40482312
126endocardial cushion morphogenesis (GO:0003203)2.38217458
127layer formation in cerebral cortex (GO:0021819)2.36722683
128mesenchyme morphogenesis (GO:0072132)2.36554649
129cochlea morphogenesis (GO:0090103)2.34864777
130response to follicle-stimulating hormone (GO:0032354)2.33066424
131neuromuscular junction development (GO:0007528)2.31964099
132positive regulation of smoothened signaling pathway (GO:0045880)2.29268592
133regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.29123068
134regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.27565816
135heart valve formation (GO:0003188)2.27434680
136lung-associated mesenchyme development (GO:0060484)2.27292250
137positive regulation of synapse maturation (GO:0090129)2.26357080
138sodium ion export (GO:0071436)2.25582029
139heart valve morphogenesis (GO:0003179)2.24136535
140neural tube development (GO:0021915)2.23141144
141regulation of catenin import into nucleus (GO:0035412)2.20041340
142maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19658071
143neuronal ion channel clustering (GO:0045161)2.17909729
144establishment of monopolar cell polarity (GO:0061162)2.16893784
145establishment or maintenance of monopolar cell polarity (GO:0061339)2.16893784
146eye morphogenesis (GO:0048592)2.16465355
147regulation of axon guidance (GO:1902667)2.12371025
148apical protein localization (GO:0045176)2.11288672
149axon extension (GO:0048675)2.10944645
150cardiac right ventricle morphogenesis (GO:0003215)2.10727413
151synaptic vesicle docking involved in exocytosis (GO:0016081)2.09916904
152cellular response to gonadotropin stimulus (GO:0071371)2.08674644
153cellular sodium ion homeostasis (GO:0006883)2.07718172
154developmental cell growth (GO:0048588)2.06685355
155establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.05003042
156body morphogenesis (GO:0010171)2.03972659
157collecting duct development (GO:0072044)2.03807005
158mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.01951686
159negative regulation of chondrocyte differentiation (GO:0032331)2.01507091
160endothelial cell morphogenesis (GO:0001886)2.00680671
161cellular response to prostaglandin stimulus (GO:0071379)1.99474386
162desmosome organization (GO:0002934)1.99187065
163skeletal muscle organ development (GO:0060538)1.97605181
164positive regulation of hormone metabolic process (GO:0032352)1.97105836
165neuron projection regeneration (GO:0031102)1.96197527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.17126202
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.05874798
3EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.91293322
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.73663952
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.72719785
6CLOCK_20551151_ChIP-Seq_293T_Human2.67054234
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.60724820
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.58268492
9EZH2_22144423_ChIP-Seq_EOC_Human2.51647845
10* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.49718234
11ZNF263_19887448_ChIP-Seq_K562_Human2.48113312
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.45761650
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44941820
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.38654824
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.33755018
16TBX20_22080862_ChIP-Seq_HEART_Mouse2.33755018
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25447849
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.22494137
19MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.21698730
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.11564193
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09071835
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.07926942
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.05688559
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.02705415
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.01483914
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.01152632
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93165705
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.90211506
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88523846
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.88212822
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.87999747
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87960761
33KDM2B_26808549_Chip-Seq_DND41_Human1.87924975
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84228080
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84174113
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.83238385
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.83172947
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82838292
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79138095
40* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79006087
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.77696677
42* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75323635
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73343441
44* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71493817
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70534409
46DROSHA_22980978_ChIP-Seq_HELA_Human1.65607946
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65599484
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60411086
49MYC_22102868_ChIP-Seq_BL_Human1.60317564
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58525433
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58055162
52KDM2B_26808549_Chip-Seq_K562_Human1.55129000
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53821220
54* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.53454915
55* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51955108
56* LXR_22292898_ChIP-Seq_THP-1_Human1.51300847
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51230379
58RACK7_27058665_Chip-Seq_MCF-7_Human1.50133141
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49759359
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48983502
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48872911
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.47885339
63ATF3_27146783_Chip-Seq_COLON_Human1.47623310
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46270167
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.44536149
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44283137
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.44204163
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43200030
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42927213
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42020173
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39217279
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38740073
73* RING1B_27294783_Chip-Seq_NPCs_Mouse1.38623812
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37754167
75TCF7_22412390_ChIP-Seq_EML_Mouse1.37689986
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36045999
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36042106
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34925565
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33578397
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33099508
81* TP53_22127205_ChIP-Seq_IMR90_Human1.33072719
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33065898
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32905026
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32474849
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31904531
86SMC4_20622854_ChIP-Seq_HELA_Human1.31797326
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29205128
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.29199705
89CREB1_26743006_Chip-Seq_LNCaP_Human1.28115022
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26784500
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26731028
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.25351778
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24806478
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.24761363
95* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22252834
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21482312
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19818921
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18796182
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18698293
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.18134170
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.17771789
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17436336
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16971445
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16230949
105P68_20966046_ChIP-Seq_HELA_Human1.15850322
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15452193
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15133286
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.13844485
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.13289787
110* TP53_23651856_ChIP-Seq_MEFs_Mouse1.11717296
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.11260848
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10318684
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10069465
114* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08483520
115BRD4_25478319_ChIP-Seq_HGPS_Human1.08258329
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07978710
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07196378
118* NANOG_21062744_ChIP-ChIP_HESCs_Human1.05847633
119NCOR1_26117541_ChIP-Seq_K562_Human1.04866972
120EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04282810
121RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04282810
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03104308
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02225937
124* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.02164813
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00494058
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00494058
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00494058
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.00272617
129EZH2_27304074_Chip-Seq_ESCs_Mouse1.00134290
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99852057
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99689189
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98760154
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98713988
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98586827
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98115840
136* CTCF_27219007_Chip-Seq_Bcells_Human0.95178702
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94083774
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92916246
139CHD1_26751641_Chip-Seq_LNCaP_Human0.92617339
140ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91771644
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91669084
142ZNF274_21170338_ChIP-Seq_K562_Hela0.90812844
143TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89870442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.01452661
2MP0004084_abnormal_cardiac_muscle4.01301087
3MP0002837_dystrophic_cardiac_calcinosis3.56946413
4MP0008438_abnormal_cutaneous_collagen3.12052723
5MP0000566_synostosis2.95199151
6MP0004036_abnormal_muscle_relaxation2.63316955
7MP0004272_abnormal_basement_membrane2.60177806
8MP0005623_abnormal_meninges_morphology2.51097036
9MP0004215_abnormal_myocardial_fiber2.50731781
10MP0003705_abnormal_hypodermis_morpholog2.50620840
11MP0003122_maternal_imprinting2.45205777
12MP0000749_muscle_degeneration2.43337556
13MP0005330_cardiomyopathy2.36036309
14MP0004087_abnormal_muscle_fiber2.32892122
15MP0004145_abnormal_muscle_electrophysio2.32496325
16MP0005503_abnormal_tendon_morphology2.29959884
17MP0000750_abnormal_muscle_regeneration2.27274962
18MP0003123_paternal_imprinting2.09995571
19MP0004858_abnormal_nervous_system2.06121088
20MP0010630_abnormal_cardiac_muscle2.05994023
21MP0003646_muscle_fatigue2.04581427
22MP0010030_abnormal_orbit_morphology2.04402601
23MP0004233_abnormal_muscle_weight2.01968423
24MP0006138_congestive_heart_failure2.00900577
25MP0003567_abnormal_fetal_cardiomyocyte1.99799811
26MP0003279_aneurysm1.95441449
27MP0002106_abnormal_muscle_physiology1.94976578
28MP0002972_abnormal_cardiac_muscle1.83518999
29MP0009780_abnormal_chondrocyte_physiolo1.80525223
30MP0000733_abnormal_muscle_development1.80168148
31MP0008775_abnormal_heart_ventricle1.76523613
32MP0005275_abnormal_skin_tensile1.76442527
33MP0005257_abnormal_intraocular_pressure1.74018128
34MP0005369_muscle_phenotype1.72557124
35MP0003283_abnormal_digestive_organ1.71785047
36MP0005620_abnormal_muscle_contractility1.71622321
37MP0001544_abnormal_cardiovascular_syste1.70952535
38MP0005385_cardiovascular_system_phenoty1.70952535
39MP0003137_abnormal_impulse_conducting1.70941543
40MP0000759_abnormal_skeletal_muscle1.67622655
41MP0003385_abnormal_body_wall1.67033878
42MP0003136_yellow_coat_color1.65775998
43MP0002234_abnormal_pharynx_morphology1.63621937
44MP0002269_muscular_atrophy1.59930159
45MP0004859_abnormal_synaptic_plasticity1.56412573
46MP0009384_cardiac_valve_regurgitation1.53046595
47MP0001958_emphysema1.50612863
48MP0000747_muscle_weakness1.45909935
49MP0010368_abnormal_lymphatic_system1.43629450
50MP0002108_abnormal_muscle_morphology1.42018703
51MP0003115_abnormal_respiratory_system1.41315770
52MP0003121_genomic_imprinting1.39606938
53MP0003941_abnormal_skin_development1.38042792
54MP0005377_hearing/vestibular/ear_phenot1.33496086
55MP0003878_abnormal_ear_physiology1.33496086
56MP0002697_abnormal_eye_size1.32664926
57MP0002089_abnormal_postnatal_growth/wei1.32535847
58MP0000537_abnormal_urethra_morphology1.32241901
59MP0003828_pulmonary_edema1.32223974
60MP0000428_abnormal_craniofacial_morphol1.31401950
61MP0002127_abnormal_cardiovascular_syste1.31392996
62MP0003942_abnormal_urinary_system1.29612462
63MP0005409_darkened_coat_color1.28876186
64MP0003566_abnormal_cell_adhesion1.24097723
65MP0000266_abnormal_heart_morphology1.22332928
66MP0004197_abnormal_fetal_growth/weight/1.21581588
67MP0006054_spinal_hemorrhage1.19500925
68MP0003119_abnormal_digestive_system1.16301192
69MP0000778_abnormal_nervous_system1.16206483
70MP0000579_abnormal_nail_morphology1.15993658
71MP0004085_abnormal_heartbeat1.15556128
72MP0002822_catalepsy1.13233924
73MP0003935_abnormal_craniofacial_develop1.10082616
74MP0000534_abnormal_ureter_morphology1.10065551
75MP0004270_analgesia1.09673631
76MP0000762_abnormal_tongue_morphology1.09290469
77MP0000462_abnormal_digestive_system1.08696173
78MP0004484_altered_response_of1.08339289
79MP0002249_abnormal_larynx_morphology1.05746710
80MP0003221_abnormal_cardiomyocyte_apopto1.05497897
81MP0000767_abnormal_smooth_muscle1.04910506
82MP0002128_abnormal_blood_circulation1.03951573
83MP0009250_abnormal_appendicular_skeleto1.03064322
84MP0003329_amyloid_beta_deposits1.02010556
85MP0000049_abnormal_middle_ear1.01933073
86MP0002925_abnormal_cardiovascular_devel1.01901426
87MP0009053_abnormal_anal_canal1.00704115
88MP0005187_abnormal_penis_morphology1.00661781
89MP0002092_abnormal_eye_morphology0.99542916
90MP0005423_abnormal_somatic_nervous0.99423998
91MP0005076_abnormal_cell_differentiation0.99273913
92MP0005508_abnormal_skeleton_morphology0.98653084
93MP0000639_abnormal_adrenal_gland0.95212070
94MP0005670_abnormal_white_adipose0.95199569
95MP0002932_abnormal_joint_morphology0.94688183
96MP0003879_abnormal_hair_cell0.94146141
97MP0003950_abnormal_plasma_membrane0.92893257
98MP0002233_abnormal_nose_morphology0.91607570
99MP0003984_embryonic_growth_retardation0.91306737
100MP0004133_heterotaxia0.91102129
101MP0002088_abnormal_embryonic_growth/wei0.91028158
102MP0001502_abnormal_circadian_rhythm0.90081993
103MP0002084_abnormal_developmental_patter0.89766504
104MP0000678_abnormal_parathyroid_gland0.88629326
105MP0000013_abnormal_adipose_tissue0.88087214
106MP0002909_abnormal_adrenal_gland0.88065960
107MP0002896_abnormal_bone_mineralization0.87454728
108MP0002938_white_spotting0.85635142
109MP0000955_abnormal_spinal_cord0.85273157
110MP0004130_abnormal_muscle_cell0.84695134
111MP0003861_abnormal_nervous_system0.83213869
112MP0005380_embryogenesis_phenotype0.83053576
113MP0001672_abnormal_embryogenesis/_devel0.83053576
114MP0002085_abnormal_embryonic_tissue0.82836900
115MP0003634_abnormal_glial_cell0.82463785
116MP0002282_abnormal_trachea_morphology0.82133404
117MP0000003_abnormal_adipose_tissue0.79977026
118MP0001299_abnormal_eye_distance/0.79720028
119MP0001879_abnormal_lymphatic_vessel0.79597671
120MP0003937_abnormal_limbs/digits/tail_de0.78831459
121MP0003755_abnormal_palate_morphology0.77965323
122MP0001661_extended_life_span0.77703823
123MP0002184_abnormal_innervation0.77070613
124MP0005666_abnormal_adipose_tissue0.76949544
125MP0003315_abnormal_perineum_morphology0.76273274
126MP0003938_abnormal_ear_development0.76191445
127MP0000432_abnormal_head_morphology0.75290222
128MP0001614_abnormal_blood_vessel0.75255130
129MP0001697_abnormal_embryo_size0.75127025
130MP0002086_abnormal_extraembryonic_tissu0.73641957
131MP0001849_ear_inflammation0.73617520
132MP0009672_abnormal_birth_weight0.73344629
133MP0005375_adipose_tissue_phenotype0.73160121
134MP0002116_abnormal_craniofacial_bone0.72584268
135MP0002114_abnormal_axial_skeleton0.71747970

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)4.85064665
2Sudden death (HP:0001699)4.81014892
3Protrusio acetabuli (HP:0003179)4.55410614
4Ankle contracture (HP:0006466)3.95055285
5Abnormality of the left ventricular outflow tract (HP:0011103)3.89945594
6Subaortic stenosis (HP:0001682)3.89945594
7Increased connective tissue (HP:0009025)3.78836535
8Muscle fiber splitting (HP:0003555)3.78376069
9Abnormality of the calf musculature (HP:0001430)3.74254224
10Ventricular tachycardia (HP:0004756)3.63407772
11Exercise-induced muscle cramps (HP:0003710)3.56073017
12Calf muscle hypertrophy (HP:0008981)3.53650236
13Mildly elevated creatine phosphokinase (HP:0008180)3.46357742
14Premature rupture of membranes (HP:0001788)3.46356922
15Hyporeflexia of lower limbs (HP:0002600)3.37891465
16Exercise-induced myalgia (HP:0003738)3.34055863
17Right ventricular cardiomyopathy (HP:0011663)3.29883896
18Difficulty climbing stairs (HP:0003551)3.19720718
19Shallow orbits (HP:0000586)3.19195914
20Atrial fibrillation (HP:0005110)3.18499914
21Lipoatrophy (HP:0100578)3.13847696
22Increased variability in muscle fiber diameter (HP:0003557)3.13227240
23Muscle hypertrophy of the lower extremities (HP:0008968)3.11884181
24Broad metatarsal (HP:0001783)3.08363685
25Bladder diverticulum (HP:0000015)2.99078530
26Primary atrial arrhythmia (HP:0001692)2.96717555
27Abnormality of skeletal muscle fiber size (HP:0012084)2.93367592
28Supraventricular arrhythmia (HP:0005115)2.93008423
29Turricephaly (HP:0000262)2.90846271
30Cerebral aneurysm (HP:0004944)2.89840787
31Supraventricular tachycardia (HP:0004755)2.84290454
32EMG: myopathic abnormalities (HP:0003458)2.79583776
33Difficulty running (HP:0009046)2.79325368
34Bronchomalacia (HP:0002780)2.71061062
35Spinal rigidity (HP:0003306)2.70360444
36Obstructive sleep apnea (HP:0002870)2.66274459
37Renal duplication (HP:0000075)2.63256271
38Ulnar bowing (HP:0003031)2.62029573
39Short 4th metacarpal (HP:0010044)2.60688570
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60688570
41Vitreoretinal degeneration (HP:0000655)2.60650356
42Lymphangioma (HP:0100764)2.60039663
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.57450014
44Aplasia involving bones of the upper limbs (HP:0009823)2.55319754
45Aplasia of the phalanges of the hand (HP:0009802)2.55319754
46Aplasia involving bones of the extremities (HP:0009825)2.55319754
47Prolonged QT interval (HP:0001657)2.49635980
48Hypoplastic ischia (HP:0003175)2.49032598
49Abnormality of the aortic arch (HP:0012303)2.45620771
50Round ear (HP:0100830)2.43031086
51Muscle fiber inclusion bodies (HP:0100299)2.42937626
52Asymmetric septal hypertrophy (HP:0001670)2.42552315
53Abnormality of the 4th metacarpal (HP:0010012)2.41440511
54Scapular winging (HP:0003691)2.40999642
55Hip contracture (HP:0003273)2.38523273
56Dilated cardiomyopathy (HP:0001644)2.37589948
57Syncope (HP:0001279)2.37380621
58Ventricular arrhythmia (HP:0004308)2.35032309
59Distal arthrogryposis (HP:0005684)2.30601192
60Coronal craniosynostosis (HP:0004440)2.29101025
61Biconcave vertebral bodies (HP:0004586)2.27990336
62Myoglobinuria (HP:0002913)2.27713429
63Deep venous thrombosis (HP:0002625)2.27598147
64Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26819854
65Cervical subluxation (HP:0003308)2.26270858
66Hyperacusis (HP:0010780)2.25027828
67Choanal stenosis (HP:0000452)2.24387830
68Myotonia (HP:0002486)2.23810685
69Limb-girdle muscle weakness (HP:0003325)2.21898644
70Bundle branch block (HP:0011710)2.17874542
71Wrist flexion contracture (HP:0001239)2.16044177
72Partial duplication of thumb phalanx (HP:0009944)2.15245822
73Abnormality of the ischium (HP:0003174)2.14305787
74Abnormality of dentin (HP:0010299)2.13571200
75Aortic dissection (HP:0002647)2.13390391
76Slender build (HP:0001533)2.10741887
77Mitral regurgitation (HP:0001653)2.10693571
78Fragile skin (HP:0001030)2.09302597
79Ventricular fibrillation (HP:0001663)2.08921404
80Myopathic facies (HP:0002058)2.07276243
81Renovascular hypertension (HP:0100817)2.05546821
82Bowel diverticulosis (HP:0005222)2.02674291
83Morphological abnormality of the middle ear (HP:0008609)2.01403875
84Soft skin (HP:0000977)2.00745448
85Palpitations (HP:0001962)2.00587288
86Rectal prolapse (HP:0002035)2.00053650
87Partial duplication of the phalanx of hand (HP:0009999)1.99777428
88Broad palm (HP:0001169)1.99729588
89Atrophic scars (HP:0001075)1.99003931
90Pterygium (HP:0001059)1.97372055
91Limb-girdle muscle atrophy (HP:0003797)1.96195460
92Nemaline bodies (HP:0003798)1.95838757
93Flat cornea (HP:0007720)1.95749840
94Thin ribs (HP:0000883)1.95322733
95Abnormality of the calcaneus (HP:0008364)1.93343151
96Aneurysm (HP:0002617)1.90912815
97Transposition of the great arteries (HP:0001669)1.89040864
98Abnormal connection of the cardiac segments (HP:0011545)1.89040864
99Abnormal ventriculo-arterial connection (HP:0011563)1.89040864
100Absent epiphyses (HP:0010577)1.88535838
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88535838
102Mitral valve prolapse (HP:0001634)1.88298798
103Stridor (HP:0010307)1.88187788
104Enlarged penis (HP:0000040)1.87827586
105Asymmetry of the thorax (HP:0001555)1.86507200
106Calcaneovalgus deformity (HP:0001848)1.85783137
107Aortic aneurysm (HP:0004942)1.85513226
108Wide anterior fontanel (HP:0000260)1.84914837
109Follicular hyperkeratosis (HP:0007502)1.84504292
110Broad face (HP:0000283)1.81211505
111Tracheal stenosis (HP:0002777)1.81069752
112Neck muscle weakness (HP:0000467)1.79960345
113Hypoplastic heart (HP:0001961)1.79669128
114Neonatal short-limb short stature (HP:0008921)1.79073362
115Elfin facies (HP:0004428)1.77963677
116Atrioventricular block (HP:0001678)1.77719700
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.77609203
118Flat acetabular roof (HP:0003180)1.75317920
119Distal upper limb amyotrophy (HP:0007149)1.74689691
120Upper limb amyotrophy (HP:0009129)1.74689691
121EMG: neuropathic changes (HP:0003445)1.72350808
122Heart block (HP:0012722)1.70556933
123Blue sclerae (HP:0000592)1.70545115
124Deformed tarsal bones (HP:0008119)1.70341444
125Abnormality of carpal bone ossification (HP:0006257)1.70270334
126Neoplasm of the heart (HP:0100544)1.69250914
127Abnormal atrioventricular conduction (HP:0005150)1.69128490
128Hypoventilation (HP:0002791)1.68835114
129Precocious puberty (HP:0000826)1.68820347
130Hepatoblastoma (HP:0002884)1.68791995
131Genu recurvatum (HP:0002816)1.68730303
132Limited hip movement (HP:0008800)1.67482713
133Testicular neoplasm (HP:0010788)1.67202230
134Selective tooth agenesis (HP:0001592)1.66781997
135Abnormality of the pubic bones (HP:0003172)1.64927770
136Arnold-Chiari malformation (HP:0002308)1.63642839
137Bell-shaped thorax (HP:0001591)1.63584597
138Advanced eruption of teeth (HP:0006288)1.63328905
139Broad thumb (HP:0011304)1.61142300
140Preauricular pit (HP:0004467)1.61121340
141Periauricular skin pits (HP:0100277)1.61121340
142Vertebral arch anomaly (HP:0008438)1.60602815
143Alacrima (HP:0000522)1.60204750
144Vertebral clefting (HP:0008428)1.60120150
145Arterial tortuosity (HP:0005116)1.58077381
146Vascular tortuosity (HP:0004948)1.56393646
147Disproportionate tall stature (HP:0001519)1.56245262
148Cutaneous finger syndactyly (HP:0010554)1.55735677
149Germ cell neoplasia (HP:0100728)1.55657633
150Cutaneous syndactyly (HP:0012725)1.55528507
151Flared iliac wings (HP:0002869)1.55205819
152Cupped ribs (HP:0000887)1.55134827
153Myokymia (HP:0002411)1.54557211
154Infantile muscular hypotonia (HP:0008947)1.54007377
155Hypoplasia of the iris (HP:0007676)1.52709051
156J-shaped sella turcica (HP:0002680)1.52624049
157Abnormal ossification of hand bones (HP:0005921)1.50532565
158Coxa vara (HP:0002812)1.49720555
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.48201911
160Overriding aorta (HP:0002623)1.48106741
161Insomnia (HP:0100785)1.47911356
162Trigonocephaly (HP:0000243)1.47469327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.88769221
2PKN24.46563532
3TTN4.35505284
4FGFR42.47239836
5PDGFRA2.45578483
6LATS12.35924235
7DMPK2.31304978
8RIPK12.27805302
9OBSCN2.22531017
10NTRK12.11946413
11MAP3K102.09394361
12LMTK22.08115467
13CDK122.01211536
14LATS21.98410986
15MYLK1.96707787
16PHKG21.95849441
17PHKG11.95849441
18PTK61.94031582
19FGFR21.91208992
20DDR21.85495810
21NEK11.84413075
22EPHA21.84344903
23EEF2K1.81957814
24ICK1.65626332
25SMG11.64018318
26TIE11.61100846
27MARK11.58740132
28MAPK151.56798648
29NTRK21.56704078
30PRKD31.50271473
31EPHB21.50025589
32PDK31.47822295
33PDK41.47822295
34ILK1.47018529
35NTRK31.34797757
36MARK21.33261162
37SIK11.30268088
38MTOR1.26468896
39PAK41.24703378
40TGFBR11.24180045
41PAK21.17069395
42PAK31.16573302
43TYRO31.13870458
44CDC42BPA1.08492368
45FGFR11.07694413
46WNK41.04738825
47MUSK1.04550962
48PTK21.02827225
49ROCK11.02195402
50PTK2B1.01079306
51FLT31.00335491
52STK38L0.99882943
53FER0.96443408
54PIK3CA0.93718651
55EPHA40.87666181
56DYRK1B0.86712015
57MAP3K60.86444799
58PASK0.84177100
59LRRK20.83822512
60FGFR30.80921233
61RPS6KB20.80752394
62SGK4940.80686656
63SGK2230.80686656
64PRKD10.80271280
65NEK20.78486668
66WNK10.78019717
67ERBB20.77776192
68AKT20.73057359
69MAP2K30.72975573
70STK240.70881461
71CDK70.70770390
72BRD40.70557457
73DAPK30.69441992
74CAMK10.69083982
75STK30.68315529
76BMX0.65680346
77CDK40.65294196
78RET0.65085987
79PDGFRB0.62709903
80CAMK1G0.61427803
81SIK20.61184595
82UHMK10.60408228
83NME10.60130829
84CAMK2G0.58813821
85KSR10.56485524
86MET0.56333945
87ROCK20.54904772
88KSR20.54864017
89PDPK10.54736239
90MAP3K70.54385779
91CAMK1D0.54315510
92STK40.51288679
93CAMK2B0.50803786
94STK380.48715173
95ERN10.48587156
96MAP2K10.48214124
97MAPK100.46949120
98CAMKK10.46801187
99PRKAA20.46339276
100MAP3K90.45552093
101CASK0.44999341
102MAP2K60.44902011
103DYRK20.44689791
104PDK20.44089745
105TGFBR20.42981355
106TESK10.42074485
107SGK30.41976181
108MAP3K80.40378516
109CDC70.39480813
110CAMK40.39238371
111PRKD20.39046012
112PAK60.38593904
113RPS6KC10.38495084
114RPS6KL10.38495084
115TTK0.38440122
116MAPKAPK30.38433318
117MAP2K20.38170946
118BCKDK0.37915267
119MAPK80.37587713
120PRKACB0.37294417
121LIMK10.37211991
122ALK0.36692957
123CDK50.36401350
124EPHB10.35723544
125RPS6KA20.34150483
126PIK3CG0.33739553
127KDR0.33476930
128AKT10.33128855
129MAPK120.31625803
130CAMK2D0.31289204
131MAP3K30.30490029
132PRKCH0.30356350
133PRKAA10.30168652
134RPS6KA60.29624924
135RPS6KA10.29284854
136MAPK10.29084572

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.58919529
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.57576133
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.46880204
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.99025963
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71201512
6ECM-receptor interaction_Homo sapiens_hsa045122.61745831
7Cardiac muscle contraction_Homo sapiens_hsa042602.56176652
8Focal adhesion_Homo sapiens_hsa045102.29983431
9Basal cell carcinoma_Homo sapiens_hsa052172.16588562
10Hedgehog signaling pathway_Homo sapiens_hsa043401.96239193
11Viral myocarditis_Homo sapiens_hsa054161.94856735
12Hippo signaling pathway_Homo sapiens_hsa043901.76135781
13Adherens junction_Homo sapiens_hsa045201.74132429
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72019381
15Tight junction_Homo sapiens_hsa045301.64195505
16Protein digestion and absorption_Homo sapiens_hsa049741.61557663
17Proteoglycans in cancer_Homo sapiens_hsa052051.60289703
18Vitamin B6 metabolism_Homo sapiens_hsa007501.50405688
19Lysine degradation_Homo sapiens_hsa003101.49029906
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46501604
21Notch signaling pathway_Homo sapiens_hsa043301.46395312
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.44801061
23Small cell lung cancer_Homo sapiens_hsa052221.42970068
24Amoebiasis_Homo sapiens_hsa051461.37515615
25TGF-beta signaling pathway_Homo sapiens_hsa043501.35565507
26cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30453872
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29190777
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22309982
29Carbon metabolism_Homo sapiens_hsa012001.22274368
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21673728
31Bile secretion_Homo sapiens_hsa049761.19406532
32Insulin resistance_Homo sapiens_hsa049311.18984311
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14645418
34MicroRNAs in cancer_Homo sapiens_hsa052061.12388001
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.11843152
36Glucagon signaling pathway_Homo sapiens_hsa049221.11786934
37Thyroid hormone synthesis_Homo sapiens_hsa049181.11098730
38Arginine biosynthesis_Homo sapiens_hsa002201.08579946
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07465009
40Insulin signaling pathway_Homo sapiens_hsa049101.07080765
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06996138
42Ovarian steroidogenesis_Homo sapiens_hsa049131.05962930
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05747123
44Steroid biosynthesis_Homo sapiens_hsa001001.05577339
45Arginine and proline metabolism_Homo sapiens_hsa003301.02617426
46Chronic myeloid leukemia_Homo sapiens_hsa052201.00011626
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98909390
48Melanogenesis_Homo sapiens_hsa049160.97954402
49mTOR signaling pathway_Homo sapiens_hsa041500.97254144
50Wnt signaling pathway_Homo sapiens_hsa043100.96959806
51Other glycan degradation_Homo sapiens_hsa005110.96222277
52HIF-1 signaling pathway_Homo sapiens_hsa040660.95993405
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.95762326
54Bladder cancer_Homo sapiens_hsa052190.95710990
55AMPK signaling pathway_Homo sapiens_hsa041520.94650177
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94483231
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93995629
58Pentose phosphate pathway_Homo sapiens_hsa000300.93513738
59Fatty acid degradation_Homo sapiens_hsa000710.93501982
60Pathways in cancer_Homo sapiens_hsa052000.92871014
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92111586
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91082703
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88383739
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87655429
65Endometrial cancer_Homo sapiens_hsa052130.86506248
66Oxytocin signaling pathway_Homo sapiens_hsa049210.86502532
67Galactose metabolism_Homo sapiens_hsa000520.86165870
68Axon guidance_Homo sapiens_hsa043600.86161828
69Prion diseases_Homo sapiens_hsa050200.85714638
70HTLV-I infection_Homo sapiens_hsa051660.85361942
71Gastric acid secretion_Homo sapiens_hsa049710.85284106
72PPAR signaling pathway_Homo sapiens_hsa033200.84730814
73Fructose and mannose metabolism_Homo sapiens_hsa000510.84686421
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84525561
75Complement and coagulation cascades_Homo sapiens_hsa046100.83255146
76Propanoate metabolism_Homo sapiens_hsa006400.83207766
77Fatty acid metabolism_Homo sapiens_hsa012120.82849041
78mRNA surveillance pathway_Homo sapiens_hsa030150.82844058
79Biosynthesis of amino acids_Homo sapiens_hsa012300.82428264
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81893572
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.81065535
82Cell cycle_Homo sapiens_hsa041100.80331697
83Estrogen signaling pathway_Homo sapiens_hsa049150.78338053
84Sulfur relay system_Homo sapiens_hsa041220.78186949
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77866884
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77494484
87Circadian entrainment_Homo sapiens_hsa047130.76568931
88Renal cell carcinoma_Homo sapiens_hsa052110.76504995
89Cocaine addiction_Homo sapiens_hsa050300.75108440
90Glutamatergic synapse_Homo sapiens_hsa047240.72857281
91Phenylalanine metabolism_Homo sapiens_hsa003600.72360423
92ErbB signaling pathway_Homo sapiens_hsa040120.72113119
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.71873482
94Melanoma_Homo sapiens_hsa052180.70628208
95Gap junction_Homo sapiens_hsa045400.70606827
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.70150460
97Dorso-ventral axis formation_Homo sapiens_hsa043200.69024223
98Thyroid cancer_Homo sapiens_hsa052160.68913545
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.68648861
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67690024
101Choline metabolism in cancer_Homo sapiens_hsa052310.67618878
102Glioma_Homo sapiens_hsa052140.67592565
103Oocyte meiosis_Homo sapiens_hsa041140.67539918
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65017018
105RNA transport_Homo sapiens_hsa030130.64864566
106Colorectal cancer_Homo sapiens_hsa052100.64723639
107Pyruvate metabolism_Homo sapiens_hsa006200.64528127
108Histidine metabolism_Homo sapiens_hsa003400.64026423
109Long-term potentiation_Homo sapiens_hsa047200.63769750
110VEGF signaling pathway_Homo sapiens_hsa043700.63132669
111Rap1 signaling pathway_Homo sapiens_hsa040150.63031535
112Platelet activation_Homo sapiens_hsa046110.62634564
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.61828145
114Type II diabetes mellitus_Homo sapiens_hsa049300.59778279
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59504318
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58781102
117cAMP signaling pathway_Homo sapiens_hsa040240.57654708
118Fatty acid biosynthesis_Homo sapiens_hsa000610.57411561
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55817406
120Amphetamine addiction_Homo sapiens_hsa050310.55773080
121Cholinergic synapse_Homo sapiens_hsa047250.55616374
122Prostate cancer_Homo sapiens_hsa052150.55400958
123Spliceosome_Homo sapiens_hsa030400.52469041
124GABAergic synapse_Homo sapiens_hsa047270.52040143
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51059660
126GnRH signaling pathway_Homo sapiens_hsa049120.50559754
127Parkinsons disease_Homo sapiens_hsa050120.49802527
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48436410
129Viral carcinogenesis_Homo sapiens_hsa052030.46089853
130Non-small cell lung cancer_Homo sapiens_hsa052230.46066123
131Toxoplasmosis_Homo sapiens_hsa051450.45890439
132Renin secretion_Homo sapiens_hsa049240.45736812
133Insulin secretion_Homo sapiens_hsa049110.40742619
134Calcium signaling pathway_Homo sapiens_hsa040200.40407549
135FoxO signaling pathway_Homo sapiens_hsa040680.39661361

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