ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hair cell differentiation (GO:0035315)	9.55266965
2	pentose metabolic process (GO:0019321)	9.49886398
3	inner ear receptor cell differentiation (GO:0060113)	9.17078114
4	diterpenoid biosynthetic process (GO:0016102)	8.43782089
5	sensory perception of sound (GO:0007605)	7.52260881
6	sensory perception of mechanical stimulus (GO:0050954)	7.40175020
7	mechanoreceptor differentiation (GO:0042490)	6.97687647
8	righting reflex (GO:0060013)	6.66432922
9	regulation of cardioblast proliferation (GO:0003264)	6.37100434
10	regulation of secondary heart field cardioblast proliferation (GO:0003266)	6.37100434
11	terpenoid biosynthetic process (GO:0016114)	5.97839385
12	inner ear morphogenesis (GO:0042472)	5.78205298
13	face development (GO:0060324)	5.67929233
14	synaptic vesicle exocytosis (GO:0016079)	5.58079420
15	retinal metabolic process (GO:0042574)	5.28657600
16	endocardial cushion morphogenesis (GO:0003203)	4.81588144
17	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.75717010
18	aorta morphogenesis (GO:0035909)	4.69522372
19	cell aggregation (GO:0098743)	4.68648669
20	cartilage condensation (GO:0001502)	4.68648669
21	lateral sprouting from an epithelium (GO:0060601)	4.68118759
22	glycoprotein catabolic process (GO:0006516)	4.60596603
23	regulation of heart morphogenesis (GO:2000826)	4.40950966
24	cochlea morphogenesis (GO:0090103)	4.40100726
25	dorsal/ventral axis specification (GO:0009950)	4.29754953
26	mesenchyme morphogenesis (GO:0072132)	4.29526229
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.25774472
28	planar cell polarity pathway involved in neural tube closure (GO:0090179)	4.23374930
29	reflex (GO:0060004)	4.19443110
30	transmission of nerve impulse (GO:0019226)	4.19391877
31	embryonic eye morphogenesis (GO:0048048)	4.17242612
32	outer ear morphogenesis (GO:0042473)	4.08826722
33	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	4.03778506
34	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	3.96331383
35	regulation of transforming growth factor beta2 production (GO:0032909)	3.92736503
36	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.92471437
37	establishment of planar polarity (GO:0001736)	3.87651034
38	establishment of tissue polarity (GO:0007164)	3.87651034
39	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.86247618
40	type B pancreatic cell proliferation (GO:0044342)	3.84954139
41	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.82182100
42	bone trabecula formation (GO:0060346)	3.82135387
43	retinal ganglion cell axon guidance (GO:0031290)	3.74298791
44	cranial nerve development (GO:0021545)	3.71336580
45	metanephric mesenchyme development (GO:0072075)	3.70550388
46	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.70010589
47	generation of neurons (GO:0048699)	3.62019538
48	detection of mechanical stimulus (GO:0050982)	3.56195619
49	nephron tubule formation (GO:0072079)	3.53381186
50	negative regulation of leukocyte chemotaxis (GO:0002689)	3.47669250
51	regulation of alkaline phosphatase activity (GO:0010692)	3.39423812
52	middle ear morphogenesis (GO:0042474)	3.36148162
53	neuromuscular process controlling balance (GO:0050885)	3.34263299
54	cardiac muscle cell proliferation (GO:0060038)	3.33378950
55	non-canonical Wnt signaling pathway (GO:0035567)	3.32177844
56	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	3.27013937
57	ectodermal placode formation (GO:0060788)	3.23817922
58	retinoic acid metabolic process (GO:0042573)	3.23263417
59	kidney mesenchyme development (GO:0072074)	3.22613845
60	regulation of extracellular matrix disassembly (GO:0010715)	3.15957476
61	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.12407625
62	regulation of macrophage cytokine production (GO:0010935)	3.09216334
63	regulation of establishment of planar polarity (GO:0090175)	3.08604312
64	cranial nerve morphogenesis (GO:0021602)	3.04352259
65	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.03518094
66	morphogenesis of embryonic epithelium (GO:0016331)	3.03307519
67	pattern specification involved in kidney development (GO:0061004)	3.02799701
68	pharyngeal system development (GO:0060037)	3.02324886
69	lung epithelium development (GO:0060428)	2.99412928
70	collagen catabolic process (GO:0030574)	2.99358738
71	regulation of organ formation (GO:0003156)	2.99143440
72	response to gravity (GO:0009629)	2.96260003
73	collagen metabolic process (GO:0032963)	2.95496154
74	lipopolysaccharide biosynthetic process (GO:0009103)	2.94753328
75	cellular response to vitamin D (GO:0071305)	2.92118109
76	organ induction (GO:0001759)	2.92109106
77	convergent extension (GO:0060026)	2.82324322
78	citrulline biosynthetic process (GO:0019240)	2.78864310
79	myoblast migration (GO:0051451)	2.77485227
80	cellular sodium ion homeostasis (GO:0006883)	2.77331798
81	tight junction assembly (GO:0070830)	2.77147265
82	multicellular organismal macromolecule metabolic process (GO:0044259)	2.76145325
83	striated muscle cell proliferation (GO:0014855)	2.75009251
84	multicellular organismal catabolic process (GO:0044243)	2.73407202
85	cell-matrix adhesion (GO:0007160)	2.71754263
86	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.66178527
87	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.65209288
88	regulation of somitogenesis (GO:0014807)	2.64635785
89	eye morphogenesis (GO:0048592)	2.64554431
90	glial cell migration (GO:0008347)	2.63735952
91	nerve development (GO:0021675)	2.61700227
92	regulation of cardioblast differentiation (GO:0051890)	2.60810267
93	mesenchymal-epithelial cell signaling (GO:0060638)	2.60553468
94	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.58642968
95	glial cell proliferation (GO:0014009)	2.57221732
96	multicellular organismal metabolic process (GO:0044236)	2.57184876
97	hippo signaling (GO:0035329)	2.56620053
98	protein localization to cell surface (GO:0034394)	2.56441270
99	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.54518451
100	auditory receptor cell differentiation (GO:0042491)	14.6519683

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.61886793
2	TRIM28_21343339_ChIP-Seq_HEK293_Human	4.32089782
3	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.37679371
4	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.94228603
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.60642459
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.21568241
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.21568241
8	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.21568241
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.20408192
10	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.09124335
11	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.09124335
12	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.07685414
13	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.07615207
14	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.96287742
15	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.84076758
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.83957510
17	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.82892594
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.81202859
19	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.78552473
20	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.76636221
21	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.76060307
22	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.75710473
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.73378159
24	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.71992708
25	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.69350788
26	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.68234979
27	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.68188621
28	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.65651792
29	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.65244858
30	AHR_22903824_ChIP-Seq_MCF-7_Human	1.64097201
31	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.63361811
32	* EZH2_27294783_Chip-Seq_ESCs_Mouse	1.60762271
33	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.60450717
34	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.58585569
35	CLOCK_20551151_ChIP-Seq_293T_Human	1.56587363
36	VDR_24787735_ChIP-Seq_THP-1_Human	1.52676181
37	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.49861358
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42764392
39	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.41313617
40	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.38243112
41	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.37986851
42	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.34665664
43	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.34212221
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32986013
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32203292
46	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.31749999
47	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.31125957
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30853316
49	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.29136577
50	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.28899653
51	* TP53_18474530_ChIP-ChIP_U2OS_Human	1.25815877
52	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.25802535
53	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.21756354
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.21544730
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19359778
56	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.19189736
57	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.17016166
58	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.16130766
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.15551072
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14066353
61	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.14012888
62	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.11881201
63	AR_21572438_ChIP-Seq_LNCaP_Human	1.11578840
64	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.09594182
65	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.09464581
66	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.09125288
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07723833
68	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.07287780
69	RXR_22108803_ChIP-Seq_LS180_Human	1.06137318
70	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.03001450
71	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.02308080
72	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.01778877
73	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.01636990
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01240525
75	KDM2B_26808549_Chip-Seq_K562_Human	1.01203743
76	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.00427813
77	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.99882994
78	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.98846767
79	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98676154
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97297263
81	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.95476476
82	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.95335913
83	* TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.93379912
84	* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92888288
85	* POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.92888288
86	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.92451898
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92354134
88	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.91297188
89	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.90490832
90	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.90277810
91	ZNF263_19887448_ChIP-Seq_K562_Human	0.87559335
92	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86993786
93	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.85664819
94	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.85045382
95	CJUN_26792858_Chip-Seq_BT549_Human	0.85004825
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.84734170
97	KDM2B_26808549_Chip-Seq_DND41_Human	0.84136484
98	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81768345
99	RACK7_27058665_Chip-Seq_MCF-7_Human	0.81645344
100	SOX2_20726797_ChIP-Seq_SW620_Human	0.81642229

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001485_abnormal_pinna_reflex	8.03372183
2	MP0005377_hearing/vestibular/ear_phenot	7.91804845
3	MP0003878_abnormal_ear_physiology	7.91804845
4	MP0001963_abnormal_hearing_physiology	4.04043835
5	* MP0000026_abnormal_inner_ear	4.03941197
6	MP0005248_abnormal_Harderian_gland	3.47885734
7	MP0001486_abnormal_startle_reflex	2.69533896
8	MP0004742_abnormal_vestibular_system	2.62147312
9	MP0003879_abnormal_hair_cell	10.5201742
10	MP0003938_abnormal_ear_development	1.80613904
11	MP0004885_abnormal_endolymph	1.76151344
12	MP0003941_abnormal_skin_development	1.58890147
13	MP0010234_abnormal_vibrissa_follicle	1.48585462
14	MP0003942_abnormal_urinary_system	1.45289432
15	MP0010030_abnormal_orbit_morphology	1.36877315
16	MP0000534_abnormal_ureter_morphology	1.31286312
17	MP0001346_abnormal_lacrimal_gland	1.25460698
18	MP0001849_ear_inflammation	1.24661618
19	MP0005623_abnormal_meninges_morphology	1.20505402
20	MP0002653_abnormal_ependyma_morphology	1.12231447
21	MP0002233_abnormal_nose_morphology	1.07140612
22	MP0010678_abnormal_skin_adnexa	1.03071045
23	MP0002249_abnormal_larynx_morphology	1.02423720
24	MP0009384_cardiac_valve_regurgitation	1.01866682
25	MP0000049_abnormal_middle_ear	1.00193515
26	MP0004272_abnormal_basement_membrane	0.99299993
27	MP0003705_abnormal_hypodermis_morpholog	0.97941150
28	MP0002102_abnormal_ear_morphology	0.92844557
29	MP0000762_abnormal_tongue_morphology	0.87906676
30	MP0006276_abnormal_autonomic_nervous	0.84744228
31	MP0000613_abnormal_salivary_gland	0.84001322
32	MP0002282_abnormal_trachea_morphology	0.83198374
33	MP0002752_abnormal_somatic_nervous	0.82088868
34	MP0000383_abnormal_hair_follicle	0.78024074
35	MP0009053_abnormal_anal_canal	0.76824139
36	MP0000566_synostosis	0.74639133
37	MP0004134_abnormal_chest_morphology	0.73458258
38	MP0001502_abnormal_circadian_rhythm	0.72096857
39	MP0002272_abnormal_nervous_system	0.68129715
40	MP0008438_abnormal_cutaneous_collagen	0.67945348
41	MP0009780_abnormal_chondrocyte_physiolo	0.66894837
42	MP0002229_neurodegeneration	0.66770174
43	MP0010352_gastrointestinal_tract_polyps	0.64032378
44	MP0002116_abnormal_craniofacial_bone	0.62466551
45	MP0002184_abnormal_innervation	0.61962401
46	MP0001299_abnormal_eye_distance/	0.60618791
47	MP0005076_abnormal_cell_differentiation	0.59270969
48	MP0001286_abnormal_eye_development	0.57990600
49	MP0008789_abnormal_olfactory_epithelium	0.56141041
50	MP0002932_abnormal_joint_morphology	0.55601392
51	MP0009250_abnormal_appendicular_skeleto	0.54256729
52	MP0002882_abnormal_neuron_morphology	0.54015631
53	MP0000537_abnormal_urethra_morphology	0.52853556
54	MP0000163_abnormal_cartilage_morphology	0.52674627
55	MP0004264_abnormal_extraembryonic_tissu	0.52135662
56	MP0002933_joint_inflammation	0.50943013
57	MP0003755_abnormal_palate_morphology	0.50533682
58	MP0003119_abnormal_digestive_system	0.50213284
59	MP0002277_abnormal_respiratory_mucosa	0.49649901
60	MP0005508_abnormal_skeleton_morphology	0.48929884
61	MP0003935_abnormal_craniofacial_develop	0.48593349
62	MP0000428_abnormal_craniofacial_morphol	0.48412638
63	MP0000733_abnormal_muscle_development	0.47458417
64	MP0002115_abnormal_skeleton_extremities	0.45499127
65	MP0003115_abnormal_respiratory_system	0.45290542
66	MP0002098_abnormal_vibrissa_morphology	0.44410209
67	MP0005408_hypopigmentation	0.43558560
68	MP0000631_abnormal_neuroendocrine_gland	0.42487746
69	MP0001340_abnormal_eyelid_morphology	0.42308301
70	MP0002089_abnormal_postnatal_growth/wei	0.40267470
71	MP0002177_abnormal_outer_ear	0.38571899
72	MP0005187_abnormal_penis_morphology	0.38325413
73	MP0004858_abnormal_nervous_system	0.37646113
74	MP0005275_abnormal_skin_tensile	0.37549661
75	MP0002109_abnormal_limb_morphology	0.35950365
76	MP0002111_abnormal_tail_morphology	0.35043485
77	MP0004859_abnormal_synaptic_plasticity	0.34195441
78	MP0000432_abnormal_head_morphology	0.34056915
79	MP0001270_distended_abdomen	0.33928667
80	MP0002938_white_spotting	0.32920577
81	MP0000579_abnormal_nail_morphology	0.32471837
82	MP0003011_delayed_dark_adaptation	0.30435965
83	MP0003567_abnormal_fetal_cardiomyocyte	0.29515222
84	MP0000516_abnormal_urinary_system	0.27996211
85	MP0005367_renal/urinary_system_phenotyp	0.27996211
86	MP0003300_gastrointestinal_ulcer	0.27561359
87	MP0002067_abnormal_sensory_capabilities	0.26902862
88	MP0003566_abnormal_cell_adhesion	0.26379858
89	MP0002113_abnormal_skeleton_development	0.25870773
90	MP0002697_abnormal_eye_size	0.25548812
91	MP0003861_abnormal_nervous_system	0.24777527
92	MP0003123_paternal_imprinting	0.23623951
93	MP0002751_abnormal_autonomic_nervous	0.23139392
94	MP0002009_preneoplasia	0.22702007
95	MP0006054_spinal_hemorrhage	0.22066096
96	MP0005645_abnormal_hypothalamus_physiol	0.22054928
97	MP0002085_abnormal_embryonic_tissue	0.21842967
98	MP0002896_abnormal_bone_mineralization	0.21691924
99	MP0002837_dystrophic_cardiac_calcinosis	0.21598255
100	MP0000678_abnormal_parathyroid_gland	0.21593596

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal auditory evoked potentials (HP:0006958)	8.73074760
2	Vitreoretinal degeneration (HP:0000655)	8.33520066
3	Severe Myopia (HP:0011003)	7.66005021
4	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	6.27013083
5	Irregular epiphyses (HP:0010582)	6.25916220
6	Hypoplastic ischia (HP:0003175)	5.72033339
7	Mild short stature (HP:0003502)	5.66005718
8	Lip pit (HP:0100267)	5.17730577
9	Abnormality of the ischium (HP:0003174)	5.02262393
10	Mixed hearing impairment (HP:0000410)	4.62763382
11	Abnormality of the vitreous humor (HP:0004327)	4.46938596
12	Abnormality of the pubic bones (HP:0003172)	4.22471307
13	Arterial tortuosity (HP:0005116)	4.06724417
14	Flattened epiphyses (HP:0003071)	4.01254632
15	Morphological abnormality of the middle ear (HP:0008609)	3.99468876
16	Osteoarthritis (HP:0002758)	3.80406064
17	Congenital sensorineural hearing impairment (HP:0008527)	3.71103023
18	Bell-shaped thorax (HP:0001591)	3.68533707
19	Genu varum (HP:0002970)	3.62978079
20	Vascular tortuosity (HP:0004948)	3.56202655
21	Vertebral clefting (HP:0008428)	3.51688997
22	Morphological abnormality of the inner ear (HP:0011390)	3.43965839
23	Enlarged epiphyses (HP:0010580)	3.00046675
24	Absent epiphyses (HP:0010577)	2.97797247
25	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.97797247
26	Small epiphyses (HP:0010585)	2.90029217
27	Protuberant abdomen (HP:0001538)	2.75874876
28	Exostoses (HP:0100777)	2.75635444
29	Absent eyelashes (HP:0000561)	2.61327356
30	Platyspondyly (HP:0000926)	2.58048713
31	Glossoptosis (HP:0000162)	2.55241447
32	Shallow orbits (HP:0000586)	2.52648889
33	Delayed epiphyseal ossification (HP:0002663)	2.52423097
34	Alacrima (HP:0000522)	2.45112493
35	Midline defect of the nose (HP:0004122)	2.43267791
36	Bicornuate uterus (HP:0000813)	2.37287355
37	Micromelia (HP:0002983)	2.33929591
38	Abnormality of the labia majora (HP:0012881)	2.33399149
39	Hypoplastic labia majora (HP:0000059)	2.31556407
40	Long toe (HP:0010511)	2.29239613
41	Synostosis of carpal bones (HP:0005048)	2.24339330
42	Recurrent corneal erosions (HP:0000495)	2.23616711
43	Spondylolisthesis (HP:0003302)	2.22232429
44	Potter facies (HP:0002009)	2.18695125
45	Facial shape deformation (HP:0011334)	2.18695125
46	Stenosis of the external auditory canal (HP:0000402)	2.17749339
47	Hepatoblastoma (HP:0002884)	2.15482390
48	Renal dysplasia (HP:0000110)	2.13346720
49	Down-sloping shoulders (HP:0200021)	2.12448268
50	Pterygium (HP:0001059)	2.11835524
51	Protrusio acetabuli (HP:0003179)	2.07860798
52	Cervical subluxation (HP:0003308)	2.07657104
53	Preauricular skin tag (HP:0000384)	2.07003728
54	Optic nerve hypoplasia (HP:0000609)	2.05708011
55	Preauricular pit (HP:0004467)	2.02919407
56	Periauricular skin pits (HP:0100277)	2.02919407
57	Abnormality of the lacrimal duct (HP:0011481)	2.02841106
58	Epiphyseal dysplasia (HP:0002656)	11.4507915
59	Retinal detachment (HP:0000541)	1.99912888
60	Aplasia involving bones of the upper limbs (HP:0009823)	1.95767980
61	Aplasia of the phalanges of the hand (HP:0009802)	1.95767980
62	Aplasia involving bones of the extremities (HP:0009825)	1.95767980
63	Camptodactyly of toe (HP:0001836)	1.93606515
64	Retinopathy (HP:0000488)	1.90893796
65	Broad metatarsal (HP:0001783)	1.89680059
66	Premature rupture of membranes (HP:0001788)	1.88453607
67	Sprengel anomaly (HP:0000912)	1.88265792
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88042748
69	Decreased lacrimation (HP:0000633)	1.84961681
70	Short palm (HP:0004279)	1.84442685
71	Genu valgum (HP:0002857)	1.82073587
72	Abnormality of the salivary glands (HP:0010286)	1.81701517
73	Skin tags (HP:0010609)	1.76495812
74	Knee flexion contracture (HP:0006380)	1.74499383
75	Abnormality of the nasolacrimal system (HP:0000614)	1.74141071
76	Skin pits (HP:0100276)	1.73110962
77	Abnormality of the vertebral endplates (HP:0005106)	1.70977519
78	Rhizomelia (HP:0008905)	1.65094636
79	Subacute progressive viral hepatitis (HP:0006572)	1.63897277
80	Aortic dissection (HP:0002647)	1.61551284
81	Abdominal distention (HP:0003270)	1.60614658
82	Bilateral microphthalmos (HP:0007633)	1.60098536
83	Bicuspid aortic valve (HP:0001647)	1.59072360
84	Abnormality of cochlea (HP:0000375)	1.58390421
85	Pili torti (HP:0003777)	1.56960762
86	Choanal stenosis (HP:0000452)	1.56643059
87	Nasolacrimal duct obstruction (HP:0000579)	1.56166344
88	Carpal synostosis (HP:0009702)	1.53223223
89	Alopecia of scalp (HP:0002293)	1.53185014
90	Mitral valve prolapse (HP:0001634)	1.52167892
91	Synostosis involving the elbow (HP:0003938)	1.52030601
92	Humeroradial synostosis (HP:0003041)	1.52030601
93	Bulbous nose (HP:0000414)	1.51228254
94	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.50151846
95	Labial hypoplasia (HP:0000066)	1.49969046
96	Progressive sensorineural hearing impairment (HP:0000408)	1.48398259
97	Renal duplication (HP:0000075)	1.46976966
98	Germ cell neoplasia (HP:0100728)	1.46714235
99	Oligodactyly (HP:0012165)	1.45835826
100	Abnormality of dentin (HP:0010299)	1.44968099

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	DDR2	9.89183371
2	EPHA3	4.07510056
3	EPHA2	3.82176503
4	EPHB1	3.78770730
5	LATS1	3.71374960
6	TRPM7	3.00113667
7	TRIB3	2.49933874
8	NTRK1	2.26174090
9	MAPK15	2.17020049
10	PKN2	2.15855125
11	FGFR4	1.99096345
12	PAK3	1.55565793
13	DYRK1B	1.50169529
14	FER	1.43642681
15	STK39	1.39688222
16	PTK6	1.37658326
17	RIPK1	1.37161910
18	IRAK1	1.35843787
19	MAP3K9	1.32451795
20	ERBB3	1.27309818
21	CSNK1A1L	1.22404107
22	MAP3K10	1.20517711
23	ERBB2	1.11023434
24	WNK4	1.04370285
25	TIE1	1.03441608
26	LATS2	1.02489825
27	PAK4	1.01840426
28	KSR2	0.90965312
29	LRRK2	0.88963136
30	PDGFRA	0.88712287
31	ALK	0.84009918
32	SIK1	0.83145701
33	CDK6	0.80031179
34	STK3	0.78645314
35	UHMK1	0.77090886
36	BMX	0.75326242
37	MET	0.73383494
38	MAP3K2	0.73292096
39	CSNK1G1	0.72881340
40	WNK1	0.72563492
41	DMPK	0.71691202
42	CSNK1G3	0.68387794
43	MST4	0.67783795
44	FGFR3	0.65977962
45	RET	0.65578669
46	PRKCE	0.64862213
47	CAMK1G	0.64476903
48	CSNK1G2	0.63046224
49	HIPK2	0.62915200
50	FGFR1	0.59917255
51	KSR1	0.54976628
52	NLK	0.53682803
53	EPHB2	0.53444590
54	TESK1	0.53426299
55	PAK6	0.52963003
56	LMTK2	0.52287396
57	MAP3K7	0.51876670
58	ROCK2	0.51750692
59	IRAK2	0.47935098
60	DAPK2	0.47867383
61	PRKD3	0.46637710
62	ILK	0.46174002
63	TTN	0.44770689
64	NTRK3	0.42801587
65	MAP3K1	0.36170346
66	CDK5	0.35742758
67	RPS6KB2	0.35670885
68	PLK2	0.34124877
69	CDK19	0.34119243
70	MAP3K13	0.33910493
71	PAK2	0.33236676
72	PTK2	0.32954231
73	CAMK1D	0.31030759
74	BCR	0.30238588
75	NUAK1	0.30158324
76	GRK1	0.30061096
77	STK38L	0.29572910
78	FYN	0.29443128
79	SCYL2	0.28824829
80	EEF2K	0.28554484
81	ERN1	0.27612945
82	EGFR	0.27554002
83	JAK2	0.27442258
84	PRKCZ	0.27402205
85	LIMK1	0.25363980
86	MINK1	0.24607872
87	GSK3A	0.24189465
88	PTK2B	0.24182343
89	MAP2K1	0.23852141
90	FLT3	0.23753520
91	CSNK1E	0.22874466
92	CDC42BPA	0.21857661
93	BMPR2	0.21389913
94	MARK3	0.20838341
95	MTOR	0.20613018
96	SRC	0.19315704
97	PRKCH	0.19122669
98	GRK6	0.18081403
99	PDGFRB	0.17846355
100	CSNK1D	0.17828989

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine metabolism_Homo sapiens_hsa00360	3.74703378
2	ECM-receptor interaction_Homo sapiens_hsa04512	2.95453449
3	Histidine metabolism_Homo sapiens_hsa00340	2.95394305
4	Protein digestion and absorption_Homo sapiens_hsa04974	2.84272339
5	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	2.49813911
6	Hippo signaling pathway_Homo sapiens_hsa04390	2.36899945
7	Basal cell carcinoma_Homo sapiens_hsa05217	2.32608236
8	beta-Alanine metabolism_Homo sapiens_hsa00410	2.16849318
9	Leukocyte transendothelial migration_Homo sapiens_hsa04670	2.14700221
10	Tight junction_Homo sapiens_hsa04530	2.03258196
11	Focal adhesion_Homo sapiens_hsa04510	1.79234850
12	Wnt signaling pathway_Homo sapiens_hsa04310	1.76461651
13	Adherens junction_Homo sapiens_hsa04520	1.65596850
14	Tyrosine metabolism_Homo sapiens_hsa00350	1.63439542
15	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.59154357
16	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.54817947
17	Proteoglycans in cancer_Homo sapiens_hsa05205	1.54268155
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.52383982
19	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.44802043
20	Melanogenesis_Homo sapiens_hsa04916	1.41499432
21	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.27831773
22	Lysine degradation_Homo sapiens_hsa00310	1.26776778
23	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.25533779
24	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.24473198
25	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.24382200
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24092409
27	Hepatitis C_Homo sapiens_hsa05160	1.23644363
28	Colorectal cancer_Homo sapiens_hsa05210	1.22868698
29	Axon guidance_Homo sapiens_hsa04360	1.20416914
30	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.18495913
31	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.16393943
32	Renal cell carcinoma_Homo sapiens_hsa05211	1.15819718
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13567633
34	Estrogen signaling pathway_Homo sapiens_hsa04915	1.08369964
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.06954656
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.06865418
37	Endometrial cancer_Homo sapiens_hsa05213	1.06011024
38	Bladder cancer_Homo sapiens_hsa05219	0.98515987
39	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.97222224
40	Notch signaling pathway_Homo sapiens_hsa04330	0.96872893
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94502400
42	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.94448921
43	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.91087288
44	Amoebiasis_Homo sapiens_hsa05146	0.89304665
45	Glioma_Homo sapiens_hsa05214	0.88890876
46	ErbB signaling pathway_Homo sapiens_hsa04012	0.88025708
47	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.86927231
48	Pancreatic cancer_Homo sapiens_hsa05212	0.86643059
49	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.85654417
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85360830
51	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.84956957
52	Prostate cancer_Homo sapiens_hsa05215	0.82091107
53	MicroRNAs in cancer_Homo sapiens_hsa05206	0.79790663
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.78478004
55	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.77318891
56	Melanoma_Homo sapiens_hsa05218	0.73615273
57	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.70946434
58	Rap1 signaling pathway_Homo sapiens_hsa04015	0.69274590
59	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65623834
60	Viral myocarditis_Homo sapiens_hsa05416	0.65028964
61	Insulin resistance_Homo sapiens_hsa04931	0.63027447
62	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.60028804
63	Pathways in cancer_Homo sapiens_hsa05200	0.59243186
64	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.58027209
65	Thyroid cancer_Homo sapiens_hsa05216	0.57761662
66	FoxO signaling pathway_Homo sapiens_hsa04068	0.57171132
67	Non-small cell lung cancer_Homo sapiens_hsa05223	0.54779480
68	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.54580073
69	Cocaine addiction_Homo sapiens_hsa05030	0.54503812
70	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.52302256
71	Gastric acid secretion_Homo sapiens_hsa04971	0.52237159
72	Small cell lung cancer_Homo sapiens_hsa05222	0.52145846
73	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.51029729
74	GnRH signaling pathway_Homo sapiens_hsa04912	0.50774111
75	Bile secretion_Homo sapiens_hsa04976	0.50192500
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47676736
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47641150
78	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.46763372
79	Ras signaling pathway_Homo sapiens_hsa04014	0.46274957
80	Gap junction_Homo sapiens_hsa04540	0.45771862
81	Toxoplasmosis_Homo sapiens_hsa05145	0.45676503
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45202624
83	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.43786220
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.43694792
85	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.43351352
86	Prolactin signaling pathway_Homo sapiens_hsa04917	0.42642658
87	VEGF signaling pathway_Homo sapiens_hsa04370	0.42073875
88	PPAR signaling pathway_Homo sapiens_hsa03320	0.41741408
89	mTOR signaling pathway_Homo sapiens_hsa04150	0.40259255
90	Prion diseases_Homo sapiens_hsa05020	0.39400740
91	Choline metabolism in cancer_Homo sapiens_hsa05231	0.39221123
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38877378
93	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.38262047
94	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.37523954
95	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.36988574
96	Insulin signaling pathway_Homo sapiens_hsa04910	0.36682953
97	Amphetamine addiction_Homo sapiens_hsa05031	0.36571647
98	Insulin secretion_Homo sapiens_hsa04911	0.36276833
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.34671202
100	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.34590984

OC90

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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