OCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)7.74637439
2tyrosine metabolic process (GO:0006570)7.64898923
3developmental pigmentation (GO:0048066)7.01166407
4endosome to melanosome transport (GO:0035646)6.41300068
5endosome to pigment granule transport (GO:0043485)6.41300068
6* phenol-containing compound biosynthetic process (GO:0046189)6.18609881
7* secondary metabolic process (GO:0019748)5.99369046
8adenine nucleotide transport (GO:0051503)5.72271048
9purine ribonucleotide transport (GO:0015868)5.44913162
10neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.97016055
11ketone body metabolic process (GO:1902224)4.88356781
12* melanocyte differentiation (GO:0030318)4.77560884
13purine nucleotide transport (GO:0015865)4.72601054
14melanosome transport (GO:0032402)4.59324005
15establishment of melanosome localization (GO:0032401)4.46467676
16* pigment cell differentiation (GO:0050931)4.38353077
17pigment granule transport (GO:0051904)4.35813678
18melanosome localization (GO:0032400)4.32190900
19presynaptic membrane assembly (GO:0097105)4.29241329
20regulation of protein sumoylation (GO:0033233)4.26693945
21establishment of pigment granule localization (GO:0051905)4.24538508
22pigment granule localization (GO:0051875)4.12587137
23short-chain fatty acid metabolic process (GO:0046459)4.06281290
24protein-chromophore linkage (GO:0018298)3.98874896
25regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.77271289
26presynaptic membrane organization (GO:0097090)3.72843112
27platelet dense granule organization (GO:0060155)3.70692376
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70032006
29neurotransmitter-gated ion channel clustering (GO:0072578)3.66218258
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60347305
31postsynaptic membrane organization (GO:0001941)3.60158219
32enteric nervous system development (GO:0048484)3.57395043
33long-chain fatty acid biosynthetic process (GO:0042759)3.47069146
34inositol phosphate catabolic process (GO:0071545)3.43641243
35* pigment biosynthetic process (GO:0046148)3.40627599
36* neuroepithelial cell differentiation (GO:0060563)3.39437720
37regulation of integrin-mediated signaling pathway (GO:2001044)3.36894259
38positive regulation of neuroblast proliferation (GO:0002052)3.35096501
39regulation of early endosome to late endosome transport (GO:2000641)3.21330451
40cellular response to reactive nitrogen species (GO:1902170)3.19288716
41regulation of neuroblast proliferation (GO:1902692)3.18121306
42reflex (GO:0060004)3.16939925
43atrial cardiac muscle cell action potential (GO:0086014)3.15344778
44cellular response to nitric oxide (GO:0071732)3.15152308
45nucleotide transport (GO:0006862)3.14022284
46mitotic G1 DNA damage checkpoint (GO:0031571)3.12316351
47antigen processing and presentation via MHC class Ib (GO:0002475)3.11364406
48positive regulation of cellular amide metabolic process (GO:0034250)3.04812412
49mesenchymal-epithelial cell signaling (GO:0060638)3.03506199
50regulation of endothelial cell chemotaxis (GO:2001026)3.03304800
51retinal metabolic process (GO:0042574)3.02901267
52aromatic amino acid family metabolic process (GO:0009072)2.99296268
53calcium-mediated signaling using intracellular calcium source (GO:0035584)2.97241019
54* phenol-containing compound metabolic process (GO:0018958)2.92794355
55retinol metabolic process (GO:0042572)2.91147146
56gap junction assembly (GO:0016264)2.88545134
57centrosome duplication (GO:0051298)2.86760602
58myotube differentiation (GO:0014902)2.82010907
59pigmentation (GO:0043473)2.79917494
60G1 DNA damage checkpoint (GO:0044783)2.79900867
61startle response (GO:0001964)2.77632987
62retinal rod cell development (GO:0046548)2.77186938
63mitotic G1/S transition checkpoint (GO:0044819)2.73848914
64autophagic vacuole fusion (GO:0000046)2.73613739
65phosphorylated carbohydrate dephosphorylation (GO:0046838)2.73428979
66inositol phosphate dephosphorylation (GO:0046855)2.73428979
67alanine transport (GO:0032328)2.73055612
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71738745
69L-serine transport (GO:0015825)2.71027187
70cAMP catabolic process (GO:0006198)2.65580390
71* pigment metabolic process (GO:0042440)2.64381210
72righting reflex (GO:0060013)2.64031257
73response to pheromone (GO:0019236)2.63973794
74osteoclast differentiation (GO:0030316)2.63932943
75regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.61947977
76dendritic spine organization (GO:0097061)2.61516473
77cyclic nucleotide catabolic process (GO:0009214)2.61129705
78neuron cell-cell adhesion (GO:0007158)2.61088297
79behavioral response to ethanol (GO:0048149)2.60485897
80regulation of sister chromatid cohesion (GO:0007063)2.59691784
81somatic stem cell division (GO:0048103)2.56666161
82regulation of superoxide anion generation (GO:0032928)2.55910507
83vesicle localization (GO:0051648)2.55763403
84negative regulation of macroautophagy (GO:0016242)2.54421288
85melanosome organization (GO:0032438)2.53105784
86endothelium development (GO:0003158)2.52957260
87basement membrane organization (GO:0071711)2.52204954
88myelin assembly (GO:0032288)2.50668776
89regulation of short-term neuronal synaptic plasticity (GO:0048172)2.48431648
90hair cell differentiation (GO:0035315)2.47828840
91cornea development in camera-type eye (GO:0061303)2.47322038
92glutamate receptor signaling pathway (GO:0007215)2.47291241
93pigment granule organization (GO:0048753)2.47265343
94proline transport (GO:0015824)2.44600356
95omega-hydroxylase P450 pathway (GO:0097267)2.44369184
96regulation of gonadotropin secretion (GO:0032276)2.40770413
97negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.39295617
98cell communication by electrical coupling (GO:0010644)2.39006225
99prostate gland growth (GO:0060736)2.38911725
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.38523631
101* columnar/cuboidal epithelial cell differentiation (GO:0002065)2.38012036
102regulation of fever generation (GO:0031620)2.37581140
103regulation of glomerular filtration (GO:0003093)2.35649431
104mechanosensory behavior (GO:0007638)2.35545563
105regulation of tight junction assembly (GO:2000810)2.35288841
106regulation of heat generation (GO:0031650)2.34710883
107ER overload response (GO:0006983)2.33768387
108mitotic sister chromatid segregation (GO:0000070)2.32582789
109positive regulation of DNA-dependent DNA replication (GO:2000105)2.32161701
110negative regulation of neurotransmitter secretion (GO:0046929)2.31819366
111auditory behavior (GO:0031223)2.31797584
112ventricular cardiac muscle cell development (GO:0055015)2.30344844
113embryonic body morphogenesis (GO:0010172)2.29481773
114negative regulation of stem cell proliferation (GO:2000647)2.27478670
115amino acid import (GO:0043090)2.26407404
116negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.25965079
117negative regulation of meiosis (GO:0045835)2.25499429
118cGMP-mediated signaling (GO:0019934)2.25002749
119polyol catabolic process (GO:0046174)2.24141659
120aggressive behavior (GO:0002118)2.24016403
121acrosome reaction (GO:0007340)2.23909199
122response to nitric oxide (GO:0071731)2.23444574
123synaptic transmission, glutamatergic (GO:0035249)2.23135512
124nucleoside transport (GO:0015858)2.23005872
125regulation of cell maturation (GO:1903429)2.22946603
126protein K6-linked ubiquitination (GO:0085020)2.22326318
127negative regulation of interleukin-1 beta production (GO:0032691)2.21694223
128sister chromatid segregation (GO:0000819)2.21686425
129inner ear receptor cell differentiation (GO:0060113)2.21345408
130piRNA metabolic process (GO:0034587)2.20145316
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19844993
132eye photoreceptor cell development (GO:0042462)2.19249652
133intracellular pH reduction (GO:0051452)2.18957165
134kidney morphogenesis (GO:0060993)2.18131602
135membrane assembly (GO:0071709)2.17878360
136mechanoreceptor differentiation (GO:0042490)2.17500734
137positive regulation of receptor recycling (GO:0001921)2.17423136
138protein maturation by protein folding (GO:0022417)2.16079408
139bone remodeling (GO:0046849)2.15878074
140organelle membrane fusion (GO:0090174)2.15149789
141urinary tract smooth muscle contraction (GO:0014848)2.14868387
142protein heterotetramerization (GO:0051290)2.14448138
143heart contraction (GO:0060047)2.14229376
144heart process (GO:0003015)2.14229376
145serine transport (GO:0032329)2.13352549
146vascular smooth muscle contraction (GO:0014829)2.12438256
147regulation of male gonad development (GO:2000018)2.12313151
148notochord development (GO:0030903)2.11545305
149photoreceptor cell development (GO:0042461)2.10506278
150negative regulation of JUN kinase activity (GO:0043508)2.09973442
151epithelial cell maturation (GO:0002070)2.09917984
152oocyte development (GO:0048599)2.09028215
153negative regulation of organelle assembly (GO:1902116)2.06807520
154mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.06641427
155sialylation (GO:0097503)2.05060700
156layer formation in cerebral cortex (GO:0021819)2.04486523
157thymus development (GO:0048538)2.04197740
158* melanin biosynthetic process (GO:0042438)19.2008672
159* melanin metabolic process (GO:0006582)17.4112370
160* secondary metabolite biosynthetic process (GO:0044550)16.2929508
161synaptonemal complex organization (GO:0070193)1.97937591
162regulation of cardioblast proliferation (GO:0003264)1.95315671
163regulation of secondary heart field cardioblast proliferation (GO:0003266)1.95315671
164pH reduction (GO:0045851)1.93798975
165secretory granule organization (GO:0033363)1.92523777
166peripheral nervous system development (GO:0007422)1.92464816
167response to dietary excess (GO:0002021)1.90735675
168body morphogenesis (GO:0010171)1.90664914
169genitalia morphogenesis (GO:0035112)1.90311362
170regulation of cilium assembly (GO:1902017)1.90240896
171establishment of nucleus localization (GO:0040023)1.88913892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.54309006
2GBX2_23144817_ChIP-Seq_PC3_Human4.90192785
3* MITF_21258399_ChIP-Seq_MELANOMA_Human3.52351678
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.43498195
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.31037145
6GATA1_22025678_ChIP-Seq_K562_Human3.24650315
7TFEB_21752829_ChIP-Seq_HELA_Human2.81928342
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78025615
9EZH2_22144423_ChIP-Seq_EOC_Human2.74350629
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.59089651
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.58593267
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53413111
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.47625971
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46135374
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.42869355
16ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.42211488
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40640132
18AR_21572438_ChIP-Seq_LNCaP_Human2.30308928
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29940666
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27786168
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17901429
22P300_19829295_ChIP-Seq_ESCs_Human2.07277429
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.05875849
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02537710
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01310646
26E2F7_22180533_ChIP-Seq_HELA_Human1.99302313
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.96716537
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.96130049
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94626857
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.92067628
31SMAD4_21799915_ChIP-Seq_A2780_Human1.91118102
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86962450
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85367675
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83352563
35TAF15_26573619_Chip-Seq_HEK293_Human1.82498655
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80014720
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78434935
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77248496
39FUS_26573619_Chip-Seq_HEK293_Human1.75839290
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75497961
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.74912878
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.73944326
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73626565
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.73149749
45* AR_25329375_ChIP-Seq_VCAP_Human1.72902452
46* STAT3_23295773_ChIP-Seq_U87_Human1.71503135
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69752880
48CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.69634338
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.69428972
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66553223
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.65705021
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65554617
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65447244
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62463540
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62395692
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.60733243
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60494108
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59755878
59P53_22387025_ChIP-Seq_ESCs_Mouse1.56443445
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54792222
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54255941
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.54039145
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52657470
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.52231913
65TP53_18474530_ChIP-ChIP_U2OS_Human1.51372046
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48103346
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47983105
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.47730693
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.47651386
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47108488
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46720419
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46720419
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46671927
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46123329
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45904218
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45510747
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.45173034
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44934258
79ER_23166858_ChIP-Seq_MCF-7_Human1.44920635
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43551275
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43416145
82* TCF4_23295773_ChIP-Seq_U87_Human1.42374915
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42224118
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42219439
85E2F1_17053090_ChIP-ChIP_MCF-7_Human1.42042958
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.41832504
87P300_18555785_Chip-Seq_ESCs_Mouse1.39383977
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.38610835
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.38575516
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38078356
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36293913
92KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35831031
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34999025
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.34801883
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34386843
96* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33881931
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33632096
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32437812
99AR_21909140_ChIP-Seq_LNCAP_Human1.32166899
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.32042212
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31714297
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.31394708
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30986494
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29505206
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28766912
106RNF2_27304074_Chip-Seq_NSC_Mouse1.28740861
107MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27833201
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27376283
109* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27257505
110RXR_22108803_ChIP-Seq_LS180_Human1.26567496
111E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25235562
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24571541
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24234564
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24157432
115* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23734313
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23132903
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22474704
118RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22247145
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.22085579
120EWS_26573619_Chip-Seq_HEK293_Human1.22018250
121KDM2B_26808549_Chip-Seq_REH_Human1.21605086
122BCAT_22108803_ChIP-Seq_LS180_Human1.21523877
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.21474734
124SOX9_26525672_Chip-Seq_HEART_Mouse1.21370820
125* JUN_21703547_ChIP-Seq_K562_Human1.21072770
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.20376886
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.19750085
128* SMAD3_21741376_ChIP-Seq_ESCs_Human1.19313095
129* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18214792
130KLF4_18555785_Chip-Seq_ESCs_Mouse1.17027729
131SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16015719
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15419996
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15419996
134ZFX_18555785_Chip-Seq_ESCs_Mouse1.14407520
135SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13344957
136* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13277389
137* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12686949
138MYC_18940864_ChIP-ChIP_HL60_Human1.12590307
139IGF1R_20145208_ChIP-Seq_DFB_Human1.11711053
140TAL1_26923725_Chip-Seq_HPCs_Mouse1.11340983
141PU1_27457419_Chip-Seq_LIVER_Mouse1.10835949
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10031824
143SRF_21415370_ChIP-Seq_HL-1_Mouse1.09779256
144YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08078876
145P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03598334
146AR_19668381_ChIP-Seq_PC3_Human1.02908613
147SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02017771
148SOX17_20123909_ChIP-Seq_XEN_Mouse1.01141277
149POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00874035
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99037003
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98662000
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98086665
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94789454
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90786532
155SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89995114
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.89189167
157MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89091958
158TBX20_22080862_ChIP-Seq_HEART_Mouse0.87835167
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.87835167
160SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87602260
161ZNF274_21170338_ChIP-Seq_K562_Hela0.87066881
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87059109
163NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84455292
164E2F1_21310950_ChIP-Seq_MCF-7_Human0.84111171
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81551650
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81304602
167MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80685621
168KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.80411693
169POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.79451308
170TET1_21490601_ChIP-Seq_MESCs_Mouse0.76681491
171ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76322098
172FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76261340
173KAP1_27257070_Chip-Seq_ESCs_Mouse0.75463179
174ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75266900
175IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75198887
176CBP_20019798_ChIP-Seq_JUKART_Human0.75198887
177ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74690389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation9.64863853
2* MP0000372_irregular_coat_pigmentation7.96460032
3* MP0003136_yellow_coat_color4.69829100
4MP0005257_abnormal_intraocular_pressure4.48457593
5MP0005408_hypopigmentation4.30179263
6MP0003011_delayed_dark_adaptation3.77922966
7MP0004381_abnormal_hair_follicle3.03735973
8MP0002877_abnormal_melanocyte_morpholog2.61435252
9* MP0000371_diluted_coat_color2.53815201
10MP0002102_abnormal_ear_morphology2.49286327
11* MP0001324_abnormal_eye_pigmentation2.43846075
12* MP0002095_abnormal_skin_pigmentation2.34454317
13MP0005646_abnormal_pituitary_gland2.32303818
14MP0005377_hearing/vestibular/ear_phenot2.26922078
15MP0003878_abnormal_ear_physiology2.26922078
16* MP0002075_abnormal_coat/hair_pigmentati2.07987368
17MP0005248_abnormal_Harderian_gland1.94070424
18* MP0001186_pigmentation_phenotype1.91041555
19MP0000566_synostosis1.90824423
20MP0002638_abnormal_pupillary_reflex1.85781255
21MP0002938_white_spotting1.76835771
22MP0005075_abnormal_melanosome_morpholog1.70999807
23* MP0000015_abnormal_ear_pigmentation1.70444054
24MP0005253_abnormal_eye_physiology1.69402751
25MP0009697_abnormal_copulation1.68313357
26MP0005174_abnormal_tail_pigmentation1.58931186
27MP0003172_abnormal_lysosome_physiology1.49243810
28MP0009780_abnormal_chondrocyte_physiolo1.48032902
29MP0002876_abnormal_thyroid_physiology1.44192417
30MP0004885_abnormal_endolymph1.33899610
31MP0005551_abnormal_eye_electrophysiolog1.32649011
32MP0001986_abnormal_taste_sensitivity1.27935917
33MP0005670_abnormal_white_adipose1.27196725
34MP0006292_abnormal_olfactory_placode1.23622854
35MP0005197_abnormal_uvea_morphology1.22839921
36MP0005058_abnormal_lysosome_morphology1.21038647
37MP0002090_abnormal_vision1.16760841
38MP0009384_cardiac_valve_regurgitation1.11816642
39MP0010234_abnormal_vibrissa_follicle1.04513838
40MP0001188_hyperpigmentation1.03460100
41MP0003787_abnormal_imprinting1.03097845
42MP0001502_abnormal_circadian_rhythm1.01504985
43MP0000569_abnormal_digit_pigmentation0.96313216
44MP0002736_abnormal_nociception_after0.92950643
45MP0000579_abnormal_nail_morphology0.91310433
46MP0002009_preneoplasia0.90759295
47MP0000678_abnormal_parathyroid_gland0.90751485
48MP0005391_vision/eye_phenotype0.89096319
49MP0002735_abnormal_chemical_nociception0.88199735
50MP0010386_abnormal_urinary_bladder0.86636252
51MP0009046_muscle_twitch0.85175806
52MP0001968_abnormal_touch/_nociception0.84737031
53MP0001963_abnormal_hearing_physiology0.81309751
54MP0009745_abnormal_behavioral_response0.77680871
55MP0001984_abnormal_olfaction0.76804423
56MP0003880_abnormal_central_pattern0.74198421
57MP0008260_abnormal_autophagy0.72953304
58MP0005386_behavior/neurological_phenoty0.71367026
59MP0004924_abnormal_behavior0.71367026
60MP0002734_abnormal_mechanical_nocicepti0.71223081
61MP0003806_abnormal_nucleotide_metabolis0.71171248
62MP0004858_abnormal_nervous_system0.70257486
63MP0000631_abnormal_neuroendocrine_gland0.69183742
64MP0000762_abnormal_tongue_morphology0.68324216
65MP0000026_abnormal_inner_ear0.66263102
66MP0000681_abnormal_thyroid_gland0.66010133
67MP0002837_dystrophic_cardiac_calcinosis0.65822648
68* MP0002557_abnormal_social/conspecific_i0.65754134
69MP0002160_abnormal_reproductive_system0.65470010
70MP0002572_abnormal_emotion/affect_behav0.65066001
71MP0010030_abnormal_orbit_morphology0.63846805
72MP0003943_abnormal_hepatobiliary_system0.61987780
73MP0003183_abnormal_peptide_metabolism0.61180035
74MP0010094_abnormal_chromosome_stability0.60973844
75MP0003635_abnormal_synaptic_transmissio0.60610217
76MP0001440_abnormal_grooming_behavior0.60543904
77MP0003941_abnormal_skin_development0.59620099
78MP0002063_abnormal_learning/memory/cond0.57136697
79MP0000427_abnormal_hair_cycle0.57091056
80MP0004270_analgesia0.55560513
81MP0004859_abnormal_synaptic_plasticity0.54829560
82MP0003111_abnormal_nucleus_morphology0.54230889
83MP0003690_abnormal_glial_cell0.54178925
84MP0003950_abnormal_plasma_membrane0.53016468
85MP0002067_abnormal_sensory_capabilities0.52921501
86MP0004019_abnormal_vitamin_homeostasis0.52683522
87MP0004043_abnormal_pH_regulation0.51049538
88MP0008438_abnormal_cutaneous_collagen0.50802651
89MP0000049_abnormal_middle_ear0.50563337
90MP0003646_muscle_fatigue0.49609690
91MP0005193_abnormal_anterior_eye0.48581088
92MP0005645_abnormal_hypothalamus_physiol0.48366748
93MP0004484_altered_response_of0.47993852
94MP0002064_seizures0.46752896
95MP0000377_abnormal_hair_follicle0.46546976
96MP0002092_abnormal_eye_morphology0.46297325
97* MP0002177_abnormal_outer_ear0.45949864
98MP0001849_ear_inflammation0.45503341
99MP0001293_anophthalmia0.45384230
100MP0001485_abnormal_pinna_reflex0.45138090
101MP0001919_abnormal_reproductive_system0.44618867
102MP0003938_abnormal_ear_development0.43917467
103MP0001486_abnormal_startle_reflex0.43719097
104MP0009250_abnormal_appendicular_skeleto0.41929185
105MP0002249_abnormal_larynx_morphology0.41640954
106MP0000778_abnormal_nervous_system0.40802011
107MP0001346_abnormal_lacrimal_gland0.40046912
108MP0005389_reproductive_system_phenotype0.39136053
109MP0001664_abnormal_digestion0.38768581
110MP0002272_abnormal_nervous_system0.38565277
111* MP0000367_abnormal_coat/_hair0.38487613
112MP0008877_abnormal_DNA_methylation0.38417711
113MP0004233_abnormal_muscle_weight0.37556519
114MP0005508_abnormal_skeleton_morphology0.36463701
115MP0000358_abnormal_cell_content/0.36341683
116MP0002229_neurodegeneration0.33899913
117MP0001299_abnormal_eye_distance/0.29989507
118MP0008932_abnormal_embryonic_tissue0.28319209
119MP0005187_abnormal_penis_morphology0.27786586
120MP0005195_abnormal_posterior_eye0.27111265
121MP0008770_decreased_survivor_rate0.26537065
122MP0000647_abnormal_sebaceous_gland0.25783657
123MP0008569_lethality_at_weaning0.25598400
124MP0003890_abnormal_embryonic-extraembry0.25415266
125MP0003453_abnormal_keratinocyte_physiol0.24755871
126MP0003077_abnormal_cell_cycle0.24253948
127MP0006054_spinal_hemorrhage0.23520150
128MP0006138_congestive_heart_failure0.23408389
129MP0003718_maternal_effect0.22619133
130* MP0005409_darkened_coat_color0.22266721
131MP0003283_abnormal_digestive_organ0.21572022
132MP0003634_abnormal_glial_cell0.21441611
133MP0002269_muscular_atrophy0.20926063
134MP0000749_muscle_degeneration0.20476311
135MP0000920_abnormal_myelination0.19155073
136MP0002751_abnormal_autonomic_nervous0.18683423
137MP0002822_catalepsy0.18372531
138MP0002697_abnormal_eye_size0.18350821
139MP0004147_increased_porphyrin_level0.17049088
140MP0002909_abnormal_adrenal_gland0.16786860
141MP0003123_paternal_imprinting0.16693476
142* MP0003698_abnormal_male_reproductive0.16005427
143MP0003385_abnormal_body_wall0.15230662
144MP0000534_abnormal_ureter_morphology0.15127712
145MP0002752_abnormal_somatic_nervous0.14447141
146MP0004134_abnormal_chest_morphology0.13704149
147MP0005499_abnormal_olfactory_system0.11885746
148MP0005394_taste/olfaction_phenotype0.11885746
149MP0002060_abnormal_skin_morphology0.11592226
150MP0001270_distended_abdomen0.11511877
151MP0003186_abnormal_redox_activity0.10950811
152* MP0002161_abnormal_fertility/fecundity0.10772821
153MP0005384_cellular_phenotype0.09902969
154MP0000639_abnormal_adrenal_gland0.09746735
155MP0000432_abnormal_head_morphology0.09506061
156MP0005379_endocrine/exocrine_gland_phen0.07627446
157* MP0003699_abnormal_female_reproductive0.07595068

Predicted human phenotypes

RankGene SetZ-score
1* Aplasia/Hypoplasia of the fovea (HP:0008060)8.55820302
2* Hypoplasia of the fovea (HP:0007750)8.55820302
3* Abnormality of the fovea (HP:0000493)8.43703240
4* Aplasia/Hypoplasia of the macula (HP:0008059)8.20477338
5* Blue irides (HP:0000635)8.08683794
6* Aplasia/Hypoplasia affecting the retina (HP:0008061)7.40346906
7* Hypopigmentation of the fundus (HP:0007894)5.96507098
8White forelock (HP:0002211)5.34146867
9Congenital sensorineural hearing impairment (HP:0008527)5.12930399
10Generalized hypopigmentation (HP:0007513)4.85421236
11Patchy hypopigmentation of hair (HP:0011365)4.85208913
12* Ocular albinism (HP:0001107)4.70320671
13Decreased electroretinogram (ERG) amplitude (HP:0000654)4.56410979
14* Iris hypopigmentation (HP:0007730)4.25602493
15Aplasia involving bones of the extremities (HP:0009825)4.25148986
16Aplasia involving bones of the upper limbs (HP:0009823)4.25148986
17Aplasia of the phalanges of the hand (HP:0009802)4.25148986
18Generalized hypopigmentation of hair (HP:0011358)3.86650263
19Attenuation of retinal blood vessels (HP:0007843)3.71705348
20Heterochromia iridis (HP:0001100)3.40081946
21Decreased central vision (HP:0007663)3.24278299
22* Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.90219005
23Peripheral hypomyelination (HP:0007182)2.87200070
24Febrile seizures (HP:0002373)2.84801113
25Spastic paraparesis (HP:0002313)2.83428276
26Hypoplastic left heart (HP:0004383)2.82235033
27Follicular hyperkeratosis (HP:0007502)2.75792067
28Pheochromocytoma (HP:0002666)2.67147495
29Amblyopia (HP:0000646)2.66221431
30Median cleft lip (HP:0000161)2.60513198
31Increased corneal curvature (HP:0100692)2.59659805
32Keratoconus (HP:0000563)2.59659805
33Hypoplasia of the iris (HP:0007676)2.57894401
34* Freckling (HP:0001480)2.54390254
35Underdeveloped nasal alae (HP:0000430)2.45230622
36Abnormality of vision evoked potentials (HP:0000649)2.41873285
37Albinism (HP:0001022)2.40354395
38Epileptic encephalopathy (HP:0200134)2.39011548
39Abnormality of liposaccharide metabolism (HP:0010968)2.35981166
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.35981166
41Abnormality of glycolipid metabolism (HP:0010969)2.35981166
42Alopecia of scalp (HP:0002293)2.32658764
43Hypoplastic heart (HP:0001961)2.32481499
44Neuroendocrine neoplasm (HP:0100634)2.31928333
45Focal motor seizures (HP:0011153)2.30473941
46Dry hair (HP:0011359)2.28625415
47Premature graying of hair (HP:0002216)2.27460054
48Alacrima (HP:0000522)2.21169838
49Hypothermia (HP:0002045)2.21043858
50Nonprogressive disorder (HP:0003680)2.18870379
51Narrow nasal bridge (HP:0000446)2.18531319
52Facial cleft (HP:0002006)2.16436396
53Corneal dystrophy (HP:0001131)2.16184405
54Chronic hepatic failure (HP:0100626)2.13259422
55Abnormality of the dental root (HP:0006486)2.12897693
56Taurodontia (HP:0000679)2.12897693
57Abnormality of permanent molar morphology (HP:0011071)2.12897693
58Long nose (HP:0003189)2.10077068
59Horizontal nystagmus (HP:0000666)2.09991677
60Short middle phalanx of the 5th finger (HP:0004220)2.07382271
61Cutaneous syndactyly (HP:0012725)2.06935284
62Tetraparesis (HP:0002273)2.05836592
63Abnormal auditory evoked potentials (HP:0006958)2.05596027
64Abnormality of molar (HP:0011077)2.03319283
65Abnormality of molar morphology (HP:0011070)2.03319283
66Paraparesis (HP:0002385)2.01870561
67Subacute progressive viral hepatitis (HP:0006572)2.01268127
68Cerebral hypomyelination (HP:0006808)2.00938990
69True hermaphroditism (HP:0010459)1.99045312
70Hyperventilation (HP:0002883)1.93083944
71Broad alveolar ridges (HP:0000187)1.90849529
72Atonic seizures (HP:0010819)1.90102195
73Decreased lacrimation (HP:0000633)1.89590212
74Abnormality of the dental pulp (HP:0006479)1.89589133
75Congenital stationary night blindness (HP:0007642)1.89563110
76Morphological abnormality of the inner ear (HP:0011390)1.88467676
77Papillary thyroid carcinoma (HP:0002895)1.87463972
78Cubitus valgus (HP:0002967)1.84873957
79Bilateral sensorineural hearing impairment (HP:0008619)1.81610966
80Nephrogenic diabetes insipidus (HP:0009806)1.77798232
81Astigmatism (HP:0000483)1.77422516
82Occipital encephalocele (HP:0002085)1.76053767
83* Photophobia (HP:0000613)1.76002086
84Abnormal gallbladder physiology (HP:0012438)1.75357724
85Cholecystitis (HP:0001082)1.75357724
86Abnormality of chromosome segregation (HP:0002916)1.73290495
87Spinal muscular atrophy (HP:0007269)1.71921068
88Mixed hearing impairment (HP:0000410)1.68954639
89Constricted visual fields (HP:0001133)1.68738287
90Degeneration of anterior horn cells (HP:0002398)1.66476959
91Abnormality of the anterior horn cell (HP:0006802)1.66476959
92Midline defect of the nose (HP:0004122)1.64519997
93Gait imbalance (HP:0002141)1.64413576
94Synophrys (HP:0000664)1.63480058
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.62764022
96Atelectasis (HP:0100750)1.62152298
97Bony spicule pigmentary retinopathy (HP:0007737)1.61022236
98Congenital primary aphakia (HP:0007707)1.60864361
99Slow-growing hair (HP:0002217)1.60766540
100Abnormality of hair growth rate (HP:0011363)1.60766540
101Hypokinesia (HP:0002375)1.59820101
102J-shaped sella turcica (HP:0002680)1.59418554
103Medial flaring of the eyebrow (HP:0010747)1.59138461
104Short hallux (HP:0010109)1.56164682
105Abnormality of incisor morphology (HP:0011063)1.55918326
106Abnormality of the phalanges of the 5th finger (HP:0004213)1.55553572
107Cutaneous melanoma (HP:0012056)1.53349340
108Abnormal rod and cone electroretinograms (HP:0008323)1.52665162
109Submucous cleft hard palate (HP:0000176)1.52343310
110Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.51412471
111Absent eyebrow (HP:0002223)1.50639613
112Melanocytic nevus (HP:0000995)1.49351717
113Abnormal hair whorl (HP:0010721)1.49243436
114Bell-shaped thorax (HP:0001591)1.48238554
115Cutaneous finger syndactyly (HP:0010554)1.47230592
116Hypermetropia (HP:0000540)1.46793990
117Lip pit (HP:0100267)1.46613389
118Choroideremia (HP:0001139)1.45515039
119Megalencephaly (HP:0001355)1.45472788
120Selective tooth agenesis (HP:0001592)1.45224078
121Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.43946243
122Pancreatic cysts (HP:0001737)1.43909732
123Renal dysplasia (HP:0000110)1.41314145
124Osteomalacia (HP:0002749)1.41158899
125Cerebral aneurysm (HP:0004944)1.41134786
126Preaxial hand polydactyly (HP:0001177)1.39606098
127Myelomeningocele (HP:0002475)1.39023240
128Progressive sensorineural hearing impairment (HP:0000408)1.38447662
129Loss of speech (HP:0002371)1.33025591
130Prolonged neonatal jaundice (HP:0006579)1.32952767
131Cerebral inclusion bodies (HP:0100314)1.32097137
132Large eyes (HP:0001090)1.27538449
133Anosmia (HP:0000458)1.25963548
134Abnormal autonomic nervous system physiology (HP:0012332)1.24850017
135Frequent falls (HP:0002359)1.24713144
136Ulnar bowing (HP:0003031)1.23337144
137Vertebral compression fractures (HP:0002953)1.23205156
138Poor head control (HP:0002421)1.21817330
139Neoplasm of the oral cavity (HP:0100649)1.20553267
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.20132768
141Supernumerary nipples (HP:0002558)1.19009441
142Abnormality of the anterior chamber (HP:0000593)1.17612415
143Abnormality of the salivary glands (HP:0010286)1.15895951
144Akinesia (HP:0002304)1.15870190
145Hand muscle atrophy (HP:0009130)1.15859269
146Tongue fasciculations (HP:0001308)1.15450289
147CNS hypomyelination (HP:0003429)1.13620220
148* Melanoma (HP:0002861)1.11715714
149Annular pancreas (HP:0001734)1.07982846
150Hypermelanotic macule (HP:0001034)1.07884277
151Aganglionic megacolon (HP:0002251)1.06266618
152Adrenal hypoplasia (HP:0000835)1.05462355
153Morphological abnormality of the middle ear (HP:0008609)1.05382704
154Hamartoma of the eye (HP:0010568)1.00609235
155Diminished movement (HP:0002374)0.98166808
156Leiomyosarcoma (HP:0100243)0.97750404
157Uterine leiomyosarcoma (HP:0002891)0.97750404
158Epidermoid cyst (HP:0200040)0.94681527
159Erectile abnormalities (HP:0100639)0.93507887
160Hypopigmented skin patches (HP:0001053)0.93435808
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)0.92543962
162Absent epiphyses (HP:0010577)0.92543962
163Fibular hypoplasia (HP:0003038)0.91618965
164Progressive neurologic deterioration (HP:0002344)0.91492675
165Abnormality of the corticospinal tract (HP:0002492)0.91361227
166Conjunctival hamartoma (HP:0100780)0.89716737
167Telecanthus (HP:0000506)0.88816079
168Anterior segment dysgenesis (HP:0007700)0.88770027
169Spinal canal stenosis (HP:0003416)0.87822236
170Transitional cell carcinoma of the bladder (HP:0006740)0.87173079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE16.81625411
2MST1R6.78389584
3TNIK4.91346591
4CASK4.77260963
5MKNK24.74508239
6MAP2K72.91163063
7AKT32.87735621
8MAP3K32.87122319
9PRKD32.84533768
10CSNK1G32.57101280
11MET2.50238687
12MAPK132.46084002
13TRIM282.44910096
14CSNK1G22.43185698
15CSNK1A1L2.42427205
16MARK32.39643848
17MKNK12.16054319
18CSNK1G12.12105358
19PRPF4B1.98333261
20LATS11.84985134
21ZAK1.83252800
22SGK21.80808920
23EPHA31.79153075
24TRIB31.70725028
25MAP3K41.70319747
26IRAK31.59959374
27BMX1.59672061
28MAPKAPK31.54521878
29INSRR1.47424498
30AKT21.45210386
31NEK61.40546645
32MAP3K21.39013566
33NTRK31.32485098
34NEK11.30323103
35MAP3K111.30164343
36STK38L1.28587320
37CDK81.28469487
38PLK21.22283097
39SGK31.21598025
40BCKDK1.17892180
41ICK1.16037514
42SGK2231.16022821
43SGK4941.16022821
44PLK11.15568046
45LMTK21.15319063
46PINK11.15151414
47PAK41.14853376
48PRKCE1.14481242
49CDK181.09583752
50MAPK121.08214023
51CDK71.06428178
52EEF2K1.05874564
53CDK11A1.05222280
54FRK1.04848262
55CDK151.04314463
56MAPK71.03922243
57PIK3CA1.02600207
58PLK30.95415326
59PTK60.94589293
60CDK60.94267213
61BMPR20.93261098
62PTK2B0.90319272
63ACVR1B0.88901858
64ABL20.87932757
65BRAF0.87790703
66ERBB40.85040004
67PRKCG0.84098732
68PRKD10.83910243
69BRSK10.82236794
70TYRO30.82130482
71MAP3K60.80341865
72CDK140.77704159
73NEK20.77433722
74PKN20.75338849
75EIF2AK10.74994090
76OBSCN0.74007611
77NUAK10.73490199
78CCNB10.73346518
79RIPK10.69404050
80CDK30.67267787
81EPHA40.66897862
82TAOK20.65889563
83TTK0.63684212
84RPS6KB10.63569659
85PNCK0.63080171
86PHKG10.62286432
87PHKG20.62286432
88SGK10.62085804
89AURKA0.60009294
90MATK0.57267321
91GRK70.56892241
92BUB10.54649200
93PRKD20.53295000
94FGFR20.52187720
95ERBB20.51559800
96RET0.50677478
97NTRK20.50120990
98ILK0.50089295
99PRKCH0.50047311
100ERBB30.49061518
101GRK50.48508966
102MAP2K40.48161837
103DYRK1A0.45770531
104PIK3CG0.45564401
105MAPK110.43202502
106TXK0.41406030
107TNK20.41363177
108CSNK1A10.41220852
109ATM0.40797435
110SIK30.40713372
111DYRK1B0.39857789
112STK380.37937592
113CDC42BPA0.37822691
114TRPM70.33340533
115KSR10.33078779
116STK40.32859445
117PDK20.31921552
118ADRBK20.30462499
119ATR0.30325562
120PRKACB0.30166383
121LIMK10.30079250
122PRKCZ0.29588765
123PDK40.29036742
124PDK30.29036742
125STK240.29006602
126CAMKK10.28260296
127PDPK10.27534641
128MAPK100.27430222
129MAPKAPK50.27388186
130ADRBK10.27007944
131EIF2AK30.26999966
132CAMK2A0.26615573
133PRKG20.26225098
134LRRK20.26012174
135FGR0.25996591
136IGF1R0.25757576
137GSK3A0.25439360
138BCR0.25146644
139MUSK0.25141574
140RPS6KA20.24749495
141AURKB0.24737521
142CSNK1D0.24459143
143PTK20.24249879
144PLK40.23455835
145FER0.22497171
146DDR20.20476549
147PRKCA0.20203691
148MELK0.19138167
149BMPR1B0.18735708
150CHEK20.18588060
151GRK10.17429102
152PRKCB0.16310303
153CAMKK20.16184140
154MARK10.15589109
155MAP2K60.15263810
156PRKACA0.14946996
157AKT10.14882548
158MAPK30.14583183
159PRKAA20.14461739
160STK30.13629155
161EIF2AK20.13328851

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003504.72392911
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62820429
3Fatty acid elongation_Homo sapiens_hsa000622.60006706
4Collecting duct acid secretion_Homo sapiens_hsa049662.55681523
5Melanogenesis_Homo sapiens_hsa049162.52647489
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26157142
7Circadian rhythm_Homo sapiens_hsa047102.25955654
8Nicotine addiction_Homo sapiens_hsa050332.21327896
9Synaptic vesicle cycle_Homo sapiens_hsa047212.16965975
10Lysosome_Homo sapiens_hsa041422.13420752
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11555182
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.89517828
13Olfactory transduction_Homo sapiens_hsa047401.78527212
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75672297
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.74525093
16Phototransduction_Homo sapiens_hsa047441.74084840
17Vitamin digestion and absorption_Homo sapiens_hsa049771.72591582
18Morphine addiction_Homo sapiens_hsa050321.69641040
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.67806055
20Insulin secretion_Homo sapiens_hsa049111.67413698
21Retinol metabolism_Homo sapiens_hsa008301.65024415
22Circadian entrainment_Homo sapiens_hsa047131.63968379
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.63941759
24Melanoma_Homo sapiens_hsa052181.62559658
25Steroid biosynthesis_Homo sapiens_hsa001001.55985274
26Vibrio cholerae infection_Homo sapiens_hsa051101.55028453
27Taste transduction_Homo sapiens_hsa047421.50166679
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49637426
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48118853
30Oocyte meiosis_Homo sapiens_hsa041141.47642956
31ABC transporters_Homo sapiens_hsa020101.42318889
32Sphingolipid metabolism_Homo sapiens_hsa006001.42032106
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41972144
34Small cell lung cancer_Homo sapiens_hsa052221.38345693
35Glutamatergic synapse_Homo sapiens_hsa047241.37535948
36Sulfur metabolism_Homo sapiens_hsa009201.35531265
37Salivary secretion_Homo sapiens_hsa049701.31334773
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28350688
39Inositol phosphate metabolism_Homo sapiens_hsa005621.25886514
40GABAergic synapse_Homo sapiens_hsa047271.24696024
41p53 signaling pathway_Homo sapiens_hsa041151.23705507
42Cell cycle_Homo sapiens_hsa041101.21292002
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20721114
44Amphetamine addiction_Homo sapiens_hsa050311.18269598
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14378580
46Long-term potentiation_Homo sapiens_hsa047201.13426838
47Oxidative phosphorylation_Homo sapiens_hsa001901.13392374
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11951450
49Ether lipid metabolism_Homo sapiens_hsa005651.07866568
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06678300
51mTOR signaling pathway_Homo sapiens_hsa041501.05715725
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04993432
53Rheumatoid arthritis_Homo sapiens_hsa053231.02931512
54Calcium signaling pathway_Homo sapiens_hsa040201.02816854
55Homologous recombination_Homo sapiens_hsa034401.02393352
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98702549
57Adherens junction_Homo sapiens_hsa045200.98415308
58Lysine degradation_Homo sapiens_hsa003100.97968047
59Linoleic acid metabolism_Homo sapiens_hsa005910.95710276
60Folate biosynthesis_Homo sapiens_hsa007900.94819483
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94287109
62Ovarian steroidogenesis_Homo sapiens_hsa049130.92502451
63Serotonergic synapse_Homo sapiens_hsa047260.92349079
64Axon guidance_Homo sapiens_hsa043600.92017790
65Protein export_Homo sapiens_hsa030600.91254293
66Renin secretion_Homo sapiens_hsa049240.90995996
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90917338
68Fatty acid metabolism_Homo sapiens_hsa012120.89165866
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88796012
70Vitamin B6 metabolism_Homo sapiens_hsa007500.88040860
71Parkinsons disease_Homo sapiens_hsa050120.87322005
72Propanoate metabolism_Homo sapiens_hsa006400.87079322
73Long-term depression_Homo sapiens_hsa047300.86604018
74Colorectal cancer_Homo sapiens_hsa052100.84334631
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82591070
76Glutathione metabolism_Homo sapiens_hsa004800.81297729
77Alzheimers disease_Homo sapiens_hsa050100.79843028
78Pentose phosphate pathway_Homo sapiens_hsa000300.78840595
79Glucagon signaling pathway_Homo sapiens_hsa049220.78350008
80Fanconi anemia pathway_Homo sapiens_hsa034600.78294989
81Huntingtons disease_Homo sapiens_hsa050160.77671842
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77414620
83Arachidonic acid metabolism_Homo sapiens_hsa005900.77013188
84cAMP signaling pathway_Homo sapiens_hsa040240.74755564
85ErbB signaling pathway_Homo sapiens_hsa040120.74158883
86Fructose and mannose metabolism_Homo sapiens_hsa000510.73761865
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71267150
88Phagosome_Homo sapiens_hsa041450.71031406
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69967659
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68695682
91Gastric acid secretion_Homo sapiens_hsa049710.68599451
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68037798
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.67871216
94Ras signaling pathway_Homo sapiens_hsa040140.66635077
95Mineral absorption_Homo sapiens_hsa049780.65663207
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.65273592
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64947657
98Non-homologous end-joining_Homo sapiens_hsa034500.64728184
99Galactose metabolism_Homo sapiens_hsa000520.64596628
100Cholinergic synapse_Homo sapiens_hsa047250.64332241
101N-Glycan biosynthesis_Homo sapiens_hsa005100.63667137
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63102993
103Other glycan degradation_Homo sapiens_hsa005110.62906726
104Base excision repair_Homo sapiens_hsa034100.62101081
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61953068
106Mismatch repair_Homo sapiens_hsa034300.61782597
107Carbon metabolism_Homo sapiens_hsa012000.61722357
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61589812
109Dopaminergic synapse_Homo sapiens_hsa047280.60393413
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.59591222
111Thyroid cancer_Homo sapiens_hsa052160.58914703
112Basal transcription factors_Homo sapiens_hsa030220.56669094
113Nitrogen metabolism_Homo sapiens_hsa009100.55621542
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54643986
115Glioma_Homo sapiens_hsa052140.53195290
116Insulin signaling pathway_Homo sapiens_hsa049100.51798534
117Endometrial cancer_Homo sapiens_hsa052130.50516877
118Prolactin signaling pathway_Homo sapiens_hsa049170.49995555
119Cocaine addiction_Homo sapiens_hsa050300.49989484
120Malaria_Homo sapiens_hsa051440.48302141
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.47830288
122Prostate cancer_Homo sapiens_hsa052150.43911984
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.43736638
124DNA replication_Homo sapiens_hsa030300.43518614
125AMPK signaling pathway_Homo sapiens_hsa041520.43386511
126Hippo signaling pathway_Homo sapiens_hsa043900.43284618
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42147718
128Wnt signaling pathway_Homo sapiens_hsa043100.41887115
129Peroxisome_Homo sapiens_hsa041460.41071794
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40884874
131Starch and sucrose metabolism_Homo sapiens_hsa005000.40191120
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39465677
133Insulin resistance_Homo sapiens_hsa049310.39130583
134Estrogen signaling pathway_Homo sapiens_hsa049150.38545352
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38200411
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37795413
137Alcoholism_Homo sapiens_hsa050340.37361948
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36573438
139GnRH signaling pathway_Homo sapiens_hsa049120.36435091
140Pyruvate metabolism_Homo sapiens_hsa006200.36379875
141TGF-beta signaling pathway_Homo sapiens_hsa043500.35660917
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33263491
143Pathways in cancer_Homo sapiens_hsa052000.33139872
144Pancreatic secretion_Homo sapiens_hsa049720.32995930
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30961037
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30647300
147Metabolic pathways_Homo sapiens_hsa011000.30383065
148Tight junction_Homo sapiens_hsa045300.29663443
149Fatty acid biosynthesis_Homo sapiens_hsa000610.29438262
150Dorso-ventral axis formation_Homo sapiens_hsa043200.29411123
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29060488
152Protein digestion and absorption_Homo sapiens_hsa049740.28966495
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.28643065
154Endocytosis_Homo sapiens_hsa041440.28395622
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28382801
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28054605
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27594611
158Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26816921
159Neurotrophin signaling pathway_Homo sapiens_hsa047220.25554009
160Biosynthesis of amino acids_Homo sapiens_hsa012300.24061786
161Nucleotide excision repair_Homo sapiens_hsa034200.23426333

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