Rank | Gene Set | Z-score |
---|---|---|
1 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.93495744 |
2 | L-phenylalanine metabolic process (GO:0006558) | 6.93495744 |
3 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.73888530 |
4 | L-phenylalanine catabolic process (GO:0006559) | 6.73888530 |
5 | aromatic amino acid family catabolic process (GO:0009074) | 5.63774189 |
6 | proteasome assembly (GO:0043248) | 5.51876792 |
7 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.35825194 |
8 | cysteine metabolic process (GO:0006534) | 5.20273351 |
9 | serine family amino acid catabolic process (GO:0009071) | 5.08421897 |
10 | glyoxylate metabolic process (GO:0046487) | 5.05741356 |
11 | bile acid biosynthetic process (GO:0006699) | 4.94622396 |
12 | kynurenine metabolic process (GO:0070189) | 4.87853293 |
13 | indole-containing compound catabolic process (GO:0042436) | 4.87644219 |
14 | indolalkylamine catabolic process (GO:0046218) | 4.87644219 |
15 | tryptophan catabolic process (GO:0006569) | 4.87644219 |
16 | urea metabolic process (GO:0019627) | 4.85029623 |
17 | urea cycle (GO:0000050) | 4.85029623 |
18 | GDP-mannose metabolic process (GO:0019673) | 4.83252553 |
19 | sulfur amino acid catabolic process (GO:0000098) | 4.82969896 |
20 | glycine metabolic process (GO:0006544) | 4.77992537 |
21 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.77692099 |
22 | regulation of triglyceride catabolic process (GO:0010896) | 4.69104353 |
23 | alpha-linolenic acid metabolic process (GO:0036109) | 4.62960679 |
24 | tryptophan metabolic process (GO:0006568) | 4.54934803 |
25 | nitrogen cycle metabolic process (GO:0071941) | 4.49911239 |
26 | amino-acid betaine metabolic process (GO:0006577) | 4.44947315 |
27 | serine family amino acid metabolic process (GO:0009069) | 4.38284085 |
28 | bile acid metabolic process (GO:0008206) | 4.32820131 |
29 | lysine catabolic process (GO:0006554) | 4.28955562 |
30 | lysine metabolic process (GO:0006553) | 4.28955562 |
31 | negative regulation of fibrinolysis (GO:0051918) | 4.21355793 |
32 | high-density lipoprotein particle remodeling (GO:0034375) | 4.19850500 |
33 | homocysteine metabolic process (GO:0050667) | 4.17088091 |
34 | complement activation, alternative pathway (GO:0006957) | 4.16114152 |
35 | purine deoxyribonucleotide catabolic process (GO:0009155) | 4.15078432 |
36 | aromatic amino acid family metabolic process (GO:0009072) | 4.14629692 |
37 | L-fucose catabolic process (GO:0042355) | 4.12710828 |
38 | fucose catabolic process (GO:0019317) | 4.12710828 |
39 | L-fucose metabolic process (GO:0042354) | 4.12710828 |
40 | viral transcription (GO:0019083) | 4.11833413 |
41 | regulation of cholesterol homeostasis (GO:2000188) | 4.10906709 |
42 | regulation of fibrinolysis (GO:0051917) | 4.09618223 |
43 | short-chain fatty acid metabolic process (GO:0046459) | 4.08201453 |
44 | regulation of protein activation cascade (GO:2000257) | 4.08137152 |
45 | protein carboxylation (GO:0018214) | 4.05508557 |
46 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.05508557 |
47 | ethanol oxidation (GO:0006069) | 4.04452206 |
48 | alpha-amino acid catabolic process (GO:1901606) | 4.01417307 |
49 | serine family amino acid biosynthetic process (GO:0009070) | 3.97188334 |
50 | triglyceride homeostasis (GO:0070328) | 3.94592519 |
51 | acylglycerol homeostasis (GO:0055090) | 3.94592519 |
52 | regulation of bile acid biosynthetic process (GO:0070857) | 3.94264934 |
53 | translational termination (GO:0006415) | 3.89315237 |
54 | negative regulation of cholesterol transport (GO:0032375) | 3.88730344 |
55 | negative regulation of sterol transport (GO:0032372) | 3.88730344 |
56 | drug catabolic process (GO:0042737) | 3.86150881 |
57 | plasma lipoprotein particle remodeling (GO:0034369) | 3.80695738 |
58 | protein-lipid complex remodeling (GO:0034368) | 3.80695738 |
59 | macromolecular complex remodeling (GO:0034367) | 3.80695738 |
60 | regulation of complement activation (GO:0030449) | 3.78979555 |
61 | cellular ketone body metabolic process (GO:0046950) | 3.78666847 |
62 | cellular modified amino acid catabolic process (GO:0042219) | 3.77156447 |
63 | GTP biosynthetic process (GO:0006183) | 3.76385992 |
64 | cellular amino acid catabolic process (GO:0009063) | 3.74200154 |
65 | bile acid and bile salt transport (GO:0015721) | 3.73209199 |
66 | regulation of cholesterol esterification (GO:0010872) | 3.72874214 |
67 | fatty acid beta-oxidation (GO:0006635) | 3.70785082 |
68 | plasma lipoprotein particle clearance (GO:0034381) | 3.67013347 |
69 | ubiquinone biosynthetic process (GO:0006744) | 3.66243645 |
70 | drug transmembrane transport (GO:0006855) | 3.65966168 |
71 | reverse cholesterol transport (GO:0043691) | 3.65914002 |
72 | glutamate metabolic process (GO:0006536) | 3.62865047 |
73 | plasma lipoprotein particle assembly (GO:0034377) | 3.61451048 |
74 | phospholipid efflux (GO:0033700) | 3.57886898 |
75 | carnitine metabolic process (GO:0009437) | 3.56160305 |
76 | fatty acid oxidation (GO:0019395) | 3.56142321 |
77 | protein complex biogenesis (GO:0070271) | 3.56130448 |
78 | coenzyme catabolic process (GO:0009109) | 3.56066303 |
79 | behavioral response to nicotine (GO:0035095) | 3.56000460 |
80 | negative regulation of B cell apoptotic process (GO:0002903) | 3.55918557 |
81 | quinone biosynthetic process (GO:1901663) | 3.55680294 |
82 | respiratory chain complex IV assembly (GO:0008535) | 3.53591842 |
83 | imidazole-containing compound metabolic process (GO:0052803) | 3.53253741 |
84 | fatty acid catabolic process (GO:0009062) | 3.52915821 |
85 | monocarboxylic acid catabolic process (GO:0072329) | 3.51621040 |
86 | tyrosine metabolic process (GO:0006570) | 3.51200272 |
87 | UTP metabolic process (GO:0046051) | 3.50985638 |
88 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.49971370 |
89 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.49971370 |
90 | base-excision repair, AP site formation (GO:0006285) | 3.48210906 |
91 | lipid oxidation (GO:0034440) | 3.48001252 |
92 | cholesterol homeostasis (GO:0042632) | 3.47278085 |
93 | organic acid catabolic process (GO:0016054) | 3.46433734 |
94 | carboxylic acid catabolic process (GO:0046395) | 3.46433734 |
95 | cytochrome complex assembly (GO:0017004) | 3.44903284 |
96 | cellular glucuronidation (GO:0052695) | 3.43505822 |
97 | positive regulation of triglyceride metabolic process (GO:0090208) | 3.43185070 |
98 | flavonoid metabolic process (GO:0009812) | 3.42213129 |
99 | DNA deamination (GO:0045006) | 3.41460971 |
100 | sterol homeostasis (GO:0055092) | 3.40850381 |
101 | 2-oxoglutarate metabolic process (GO:0006103) | 3.39436562 |
102 | cellular biogenic amine catabolic process (GO:0042402) | 3.39280136 |
103 | amine catabolic process (GO:0009310) | 3.39280136 |
104 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.39208126 |
105 | urate metabolic process (GO:0046415) | 3.38846795 |
106 | positive regulation of lipid catabolic process (GO:0050996) | 3.36463398 |
107 | aldehyde catabolic process (GO:0046185) | 3.34850290 |
108 | translational elongation (GO:0006414) | 3.33390653 |
109 | aspartate family amino acid catabolic process (GO:0009068) | 3.33130040 |
110 | regulation of triglyceride metabolic process (GO:0090207) | 3.32684510 |
111 | negative regulation of telomere maintenance (GO:0032205) | 3.31972129 |
112 | exogenous drug catabolic process (GO:0042738) | 3.31845482 |
113 | DNA damage response, detection of DNA damage (GO:0042769) | 3.31475091 |
114 | drug transport (GO:0015893) | 3.31072602 |
115 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.30421359 |
116 | intestinal cholesterol absorption (GO:0030299) | 3.30395400 |
117 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.29940926 |
118 | NADH dehydrogenase complex assembly (GO:0010257) | 3.29940926 |
119 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.29940926 |
120 | benzene-containing compound metabolic process (GO:0042537) | 3.29647165 |
121 | phospholipid homeostasis (GO:0055091) | 3.29161060 |
122 | acetyl-CoA metabolic process (GO:0006084) | 3.27761590 |
123 | UTP biosynthetic process (GO:0006228) | 3.26774216 |
124 | mannosylation (GO:0097502) | 3.16617604 |
125 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.15728155 |
126 | ubiquinone metabolic process (GO:0006743) | 3.12659338 |
127 | fucosylation (GO:0036065) | 3.09698220 |
128 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.98780953 |
129 | electron transport chain (GO:0022900) | 2.91230082 |
130 | respiratory electron transport chain (GO:0022904) | 2.88336830 |
131 | ATP synthesis coupled proton transport (GO:0015986) | 2.84135943 |
132 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.84135943 |
133 | deoxyribonucleotide catabolic process (GO:0009264) | 2.82082399 |
134 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.80043572 |
135 | cellular response to ATP (GO:0071318) | 2.77009848 |
136 | transepithelial transport (GO:0070633) | 2.74128356 |
137 | metallo-sulfur cluster assembly (GO:0031163) | 2.71110844 |
138 | iron-sulfur cluster assembly (GO:0016226) | 2.71110844 |
139 | platelet dense granule organization (GO:0060155) | 2.69275852 |
140 | fucose metabolic process (GO:0006004) | 2.69140036 |
141 | regulation of B cell apoptotic process (GO:0002902) | 2.66898037 |
142 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.66488914 |
143 | cellular response to zinc ion (GO:0071294) | 2.66055952 |
144 | axonemal dynein complex assembly (GO:0070286) | 2.63596004 |
145 | arginine metabolic process (GO:0006525) | 2.59899150 |
146 | L-methionine salvage (GO:0071267) | 2.59644943 |
147 | L-methionine biosynthetic process (GO:0071265) | 2.59644943 |
148 | amino acid salvage (GO:0043102) | 2.59644943 |
149 | nucleoside transmembrane transport (GO:1901642) | 2.58459911 |
150 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 2.57993659 |
151 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 2.57993659 |
152 | phosphatidylglycerol biosynthetic process (GO:0006655) | 2.56596308 |
153 | folic acid metabolic process (GO:0046655) | 2.55682535 |
154 | quinone metabolic process (GO:1901661) | 2.54977581 |
155 | nucleotide transmembrane transport (GO:1901679) | 2.51548296 |
156 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.51394800 |
157 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.50321744 |
158 | deoxyribose phosphate catabolic process (GO:0046386) | 2.50212126 |
159 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.49476427 |
160 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.44256048 |
161 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.43429958 |
162 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.43429958 |
163 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.40477234 |
164 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.39491504 |
165 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.39199678 |
166 | hydrogen ion transmembrane transport (GO:1902600) | 2.38349982 |
167 | GPI anchor biosynthetic process (GO:0006506) | 2.38173522 |
168 | regulation of guanylate cyclase activity (GO:0031282) | 2.37232571 |
169 | glutathione derivative metabolic process (GO:1901685) | 2.36818613 |
170 | glutathione derivative biosynthetic process (GO:1901687) | 2.36818613 |
171 | viral protein processing (GO:0019082) | 2.35994247 |
172 | S-adenosylmethionine metabolic process (GO:0046500) | 2.34835657 |
173 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.34671068 |
174 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.33019540 |
175 | NAD biosynthetic process (GO:0009435) | 2.32370696 |
176 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.30486500 |
177 | detection of light stimulus involved in visual perception (GO:0050908) | 2.30486500 |
178 | CTP metabolic process (GO:0046036) | 2.28125333 |
179 | CTP biosynthetic process (GO:0006241) | 2.28125333 |
180 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.27893714 |
181 | proton transport (GO:0015992) | 2.27577626 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 8.85083889 |
2 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 6.13997217 |
3 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 5.62345552 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 4.72393071 |
5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.56758155 |
6 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.37664030 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.08265948 |
8 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 3.83380064 |
9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.33182949 |
10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.81132408 |
11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.76879403 |
12 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.72072429 |
13 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.62456821 |
14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.44239041 |
15 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.29710730 |
16 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 2.28866235 |
17 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.09775396 |
18 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.06197657 |
19 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.98424378 |
20 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.93439338 |
21 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.90458139 |
22 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.90109655 |
23 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.88346556 |
24 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.87475408 |
25 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.85018093 |
26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.82144467 |
27 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.79418838 |
28 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.74135586 |
29 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.73379250 |
30 | P300_27268052_Chip-Seq_Bcells_Human | 1.73245776 |
31 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.72382886 |
32 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.71023406 |
33 | ERA_21632823_ChIP-Seq_H3396_Human | 1.66491005 |
34 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.65538457 |
35 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.65249639 |
36 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.63221678 |
37 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.61063488 |
38 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.55504771 |
39 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.51017622 |
40 | SA1_27219007_Chip-Seq_Bcells_Human | 1.50398545 |
41 | * TAF2_19829295_ChIP-Seq_ESCs_Human | 1.46792331 |
42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.46342221 |
43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.46330599 |
44 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.44723577 |
45 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.36520129 |
46 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.35441276 |
47 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.35139548 |
48 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.35042292 |
49 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.31641436 |
50 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.30578540 |
51 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29532900 |
52 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29349086 |
53 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.28443654 |
54 | * ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.27856910 |
55 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.26645819 |
56 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.25527721 |
57 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.25167054 |
58 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.24601208 |
59 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.24200846 |
60 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.20410610 |
61 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.18547128 |
62 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.18215170 |
63 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.17674130 |
64 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.17663431 |
65 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.17378380 |
66 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.16243984 |
67 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.15764810 |
68 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.15594631 |
69 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.15470378 |
70 | SOX2_21211035_ChIP-Seq_LN229_Human | 1.15399518 |
71 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.14743801 |
72 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.11604058 |
73 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.10602901 |
74 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.10299163 |
75 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.10061356 |
76 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.09654402 |
77 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 1.09612517 |
78 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.09498607 |
79 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.09447746 |
80 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09374579 |
81 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.09011933 |
82 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.08865603 |
83 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.08649036 |
84 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.08510809 |
85 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.08349063 |
86 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.08303862 |
87 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.07590482 |
88 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.06117123 |
89 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.06083482 |
90 | P68_20966046_ChIP-Seq_HELA_Human | 1.05829277 |
91 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.05817077 |
92 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.05589193 |
93 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.05113207 |
94 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.04942104 |
95 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.04702679 |
96 | UTX_26944678_Chip-Seq_JUKART_Human | 1.04165102 |
97 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.04005619 |
98 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.01515938 |
99 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01288594 |
100 | MYC_22102868_ChIP-Seq_BL_Human | 1.01279139 |
101 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.00969444 |
102 | GATA1_22025678_ChIP-Seq_K562_Human | 1.00357855 |
103 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.00272077 |
104 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.99570454 |
105 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.99477378 |
106 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.99256878 |
107 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.98257564 |
108 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98211529 |
109 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.98024568 |
110 | * MAF_26560356_Chip-Seq_TH1_Human | 0.97971016 |
111 | MAF_26560356_Chip-Seq_TH2_Human | 0.97847972 |
112 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.96610626 |
113 | * VDR_24763502_ChIP-Seq_THP-1_Human | 0.96048352 |
114 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.95842171 |
115 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.93349186 |
116 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.92690293 |
117 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.91163938 |
118 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.90471891 |
119 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.89970236 |
120 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.89655914 |
121 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.88529872 |
122 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.87568731 |
123 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.87099891 |
124 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.87018816 |
125 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.86972200 |
126 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.86378492 |
127 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.85670176 |
128 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.85289393 |
129 | ATF3_27146783_Chip-Seq_COLON_Human | 0.84684946 |
130 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.83915155 |
131 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.83826850 |
132 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.80645330 |
133 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.80600047 |
134 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.80047509 |
135 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.78433739 |
136 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.78020075 |
137 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.77781221 |
138 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.77501571 |
139 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.77427359 |
140 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.77399827 |
141 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.77094097 |
142 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.76795889 |
143 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.76345863 |
144 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.75720463 |
145 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.75566856 |
146 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.75311500 |
147 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.75192987 |
148 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.74534045 |
149 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.74453908 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005360_urolithiasis | 7.18945641 |
2 | MP0002139_abnormal_hepatobiliary_system | 7.02041079 |
3 | MP0005085_abnormal_gallbladder_physiolo | 5.40234521 |
4 | MP0005365_abnormal_bile_salt | 5.11701937 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.24124503 |
6 | MP0003252_abnormal_bile_duct | 3.48713946 |
7 | MP0005083_abnormal_biliary_tract | 3.39769561 |
8 | MP0009840_abnormal_foam_cell | 3.12808184 |
9 | MP0010329_abnormal_lipoprotein_level | 2.97045734 |
10 | MP0003806_abnormal_nucleotide_metabolis | 2.96106716 |
11 | MP0001986_abnormal_taste_sensitivity | 2.89231124 |
12 | MP0001666_abnormal_nutrient_absorption | 2.73722884 |
13 | MP0005332_abnormal_amino_acid | 2.65034506 |
14 | MP0009379_abnormal_foot_pigmentation | 2.39038451 |
15 | MP0002876_abnormal_thyroid_physiology | 2.31182755 |
16 | MP0002138_abnormal_hepatobiliary_system | 2.20581644 |
17 | MP0004019_abnormal_vitamin_homeostasis | 2.18336026 |
18 | MP0003195_calcinosis | 2.12614133 |
19 | MP0004147_increased_porphyrin_level | 2.12432199 |
20 | MP0000609_abnormal_liver_physiology | 2.05237899 |
21 | MP0003191_abnormal_cellular_cholesterol | 2.02866947 |
22 | MP0003011_delayed_dark_adaptation | 1.86442125 |
23 | MP0005319_abnormal_enzyme/_coenzyme | 1.86219470 |
24 | MP0002736_abnormal_nociception_after | 1.83723840 |
25 | MP0002118_abnormal_lipid_homeostasis | 1.82686937 |
26 | MP0001968_abnormal_touch/_nociception | 1.77418251 |
27 | MP0009643_abnormal_urine_homeostasis | 1.67461553 |
28 | MP0003868_abnormal_feces_composition | 1.56756160 |
29 | MP0001764_abnormal_homeostasis | 1.47066054 |
30 | MP0002277_abnormal_respiratory_mucosa | 1.46765808 |
31 | MP0006082_CNS_inflammation | 1.46566439 |
32 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.45472639 |
33 | MP0002653_abnormal_ependyma_morphology | 1.44606896 |
34 | MP0005410_abnormal_fertilization | 1.44129221 |
35 | MP0005551_abnormal_eye_electrophysiolog | 1.43521419 |
36 | MP0002837_dystrophic_cardiac_calcinosis | 1.42253650 |
37 | MP0005670_abnormal_white_adipose | 1.42165051 |
38 | MP0002148_abnormal_hypersensitivity_rea | 1.36118475 |
39 | MP0003300_gastrointestinal_ulcer | 1.35402995 |
40 | MP0001919_abnormal_reproductive_system | 1.34899523 |
41 | MP0003656_abnormal_erythrocyte_physiolo | 1.33796439 |
42 | MP0005671_abnormal_response_to | 1.33149280 |
43 | MP0005636_abnormal_mineral_homeostasis | 1.32079114 |
44 | MP0005387_immune_system_phenotype | 1.30371899 |
45 | MP0001790_abnormal_immune_system | 1.30371899 |
46 | MP0006036_abnormal_mitochondrial_physio | 1.30353378 |
47 | MP0003186_abnormal_redox_activity | 1.29089263 |
48 | MP0002735_abnormal_chemical_nociception | 1.27718155 |
49 | MP0005423_abnormal_somatic_nervous | 1.23693034 |
50 | MP0003172_abnormal_lysosome_physiology | 1.22684714 |
51 | MP0009785_altered_susceptibility_to | 1.21871304 |
52 | MP0009333_abnormal_splenocyte_physiolog | 1.21516390 |
53 | MP0005666_abnormal_adipose_tissue | 1.16353686 |
54 | MP0003705_abnormal_hypodermis_morpholog | 1.13552516 |
55 | MP0002723_abnormal_immune_serum | 1.12878797 |
56 | MP0000598_abnormal_liver_morphology | 1.11047893 |
57 | MP0001905_abnormal_dopamine_level | 1.10465282 |
58 | MP0001800_abnormal_humoral_immune | 1.10156922 |
59 | MP0005451_abnormal_body_composition | 1.10130009 |
60 | MP0005389_reproductive_system_phenotype | 1.09275971 |
61 | MP0001502_abnormal_circadian_rhythm | 1.08459659 |
62 | MP0002419_abnormal_innate_immunity | 1.06574197 |
63 | MP0008469_abnormal_protein_level | 1.03856683 |
64 | MP0000538_abnormal_urinary_bladder | 1.02375966 |
65 | MP0002160_abnormal_reproductive_system | 1.01885323 |
66 | MP0002796_impaired_skin_barrier | 1.01683834 |
67 | MP0001663_abnormal_digestive_system | 1.01281595 |
68 | MP0005084_abnormal_gallbladder_morpholo | 1.00556379 |
69 | MP0001835_abnormal_antigen_presentation | 0.98865455 |
70 | MP0002452_abnormal_antigen_presenting | 0.97283594 |
71 | MP0004130_abnormal_muscle_cell | 0.95927884 |
72 | MP0009764_decreased_sensitivity_to | 0.95568475 |
73 | MP0002693_abnormal_pancreas_physiology | 0.94518146 |
74 | MP0005220_abnormal_exocrine_pancreas | 0.94385559 |
75 | MP0001756_abnormal_urination | 0.94187121 |
76 | MP0009763_increased_sensitivity_to | 0.92717673 |
77 | MP0002132_abnormal_respiratory_system | 0.92466476 |
78 | MP0005377_hearing/vestibular/ear_phenot | 0.91350396 |
79 | MP0003878_abnormal_ear_physiology | 0.91350396 |
80 | MP0009642_abnormal_blood_homeostasis | 0.91312676 |
81 | MP0003718_maternal_effect | 0.91306449 |
82 | MP0001819_abnormal_immune_cell | 0.90947098 |
83 | MP0005000_abnormal_immune_tolerance | 0.90941125 |
84 | MP0002420_abnormal_adaptive_immunity | 0.90231236 |
85 | MP0010386_abnormal_urinary_bladder | 0.89638420 |
86 | MP0003786_premature_aging | 0.89338409 |
87 | MP0001873_stomach_inflammation | 0.87630099 |
88 | MP0002136_abnormal_kidney_physiology | 0.86768464 |
89 | MP0005253_abnormal_eye_physiology | 0.86407562 |
90 | MP0004142_abnormal_muscle_tone | 0.85738387 |
91 | MP0005381_digestive/alimentary_phenotyp | 0.85016128 |
92 | MP0002928_abnormal_bile_duct | 0.84685161 |
93 | MP0009384_cardiac_valve_regurgitation | 0.84323215 |
94 | MP0004381_abnormal_hair_follicle | 0.83433164 |
95 | MP0002971_abnormal_brown_adipose | 0.83430536 |
96 | MP0004185_abnormal_adipocyte_glucose | 0.83148329 |
97 | MP0003436_decreased_susceptibility_to | 0.82985315 |
98 | MP0005171_absent_coat_pigmentation | 0.82773000 |
99 | MP0002254_reproductive_system_inflammat | 0.82678293 |
100 | MP0003724_increased_susceptibility_to | 0.81372314 |
101 | MP0002733_abnormal_thermal_nociception | 0.81131401 |
102 | MP0005334_abnormal_fat_pad | 0.81079067 |
103 | MP0004145_abnormal_muscle_electrophysio | 0.79250322 |
104 | MP0004133_heterotaxia | 0.77454492 |
105 | MP0001765_abnormal_ion_homeostasis | 0.76896813 |
106 | MP0003075_altered_response_to | 0.76513261 |
107 | MP0005075_abnormal_melanosome_morpholog | 0.75175829 |
108 | MP0002909_abnormal_adrenal_gland | 0.74448364 |
109 | MP0002078_abnormal_glucose_homeostasis | 0.73443377 |
110 | MP0003303_peritoneal_inflammation | 0.72676176 |
111 | MP0010155_abnormal_intestine_physiology | 0.72230141 |
112 | MP0005375_adipose_tissue_phenotype | 0.72057041 |
113 | MP0005647_abnormal_sex_gland | 0.71564412 |
114 | MP0000604_amyloidosis | 0.70810019 |
115 | MP0005408_hypopigmentation | 0.70348948 |
116 | MP0009053_abnormal_anal_canal | 0.66289124 |
117 | MP0005464_abnormal_platelet_physiology | 0.61986784 |
118 | MP0005376_homeostasis/metabolism_phenot | 0.60653025 |
119 | MP0000685_abnormal_immune_system | 0.57667735 |
120 | MP0005501_abnormal_skin_physiology | 0.55320137 |
121 | MP0005330_cardiomyopathy | 0.55144173 |
122 | MP0001944_abnormal_pancreas_morphology | 0.53862126 |
123 | MP0001845_abnormal_inflammatory_respons | 0.53823750 |
124 | MP0003866_abnormal_defecation | 0.52388582 |
125 | MP0010368_abnormal_lymphatic_system | 0.50259388 |
126 | MP0006035_abnormal_mitochondrial_morpho | 0.49909811 |
127 | MP0005535_abnormal_body_temperature | 0.48812150 |
128 | MP0009765_abnormal_xenobiotic_induced | 0.48655808 |
129 | MP0001661_extended_life_span | 0.48363229 |
130 | MP0009672_abnormal_birth_weight | 0.48170229 |
131 | MP0002060_abnormal_skin_morphology | 0.48113446 |
132 | MP0005174_abnormal_tail_pigmentation | 0.47645750 |
133 | MP0005058_abnormal_lysosome_morphology | 0.47226611 |
134 | MP0003638_abnormal_response/metabolism_ | 0.47052693 |
135 | MP0005166_decreased_susceptibility_to | 0.45368914 |
136 | MP0008961_abnormal_basal_metabolism | 0.44406176 |
137 | MP0000477_abnormal_intestine_morphology | 0.44042071 |
138 | MP0009115_abnormal_fat_cell | 0.43702423 |
139 | MP0001853_heart_inflammation | 0.43427919 |
140 | MP0002166_altered_tumor_susceptibility | 0.43364888 |
141 | MP0008872_abnormal_physiological_respon | 0.43005072 |
142 | MP0000230_abnormal_systemic_arterial | 0.42112801 |
143 | MP0005448_abnormal_energy_balance | 0.41105217 |
144 | MP0004043_abnormal_pH_regulation | 0.40827010 |
145 | MP0000462_abnormal_digestive_system | 0.39997395 |
146 | MP0003453_abnormal_keratinocyte_physiol | 0.39663931 |
147 | MP0002135_abnormal_kidney_morphology | 0.38832946 |
148 | MP0005025_abnormal_response_to | 0.38157772 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 6.36704605 |
2 | Intrahepatic cholestasis (HP:0001406) | 5.66023210 |
3 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.35273813 |
4 | Xanthomatosis (HP:0000991) | 5.24466533 |
5 | Deep venous thrombosis (HP:0002625) | 5.10075674 |
6 | Hyperglycinemia (HP:0002154) | 4.72261732 |
7 | Hypobetalipoproteinemia (HP:0003563) | 4.70295347 |
8 | Prolonged partial thromboplastin time (HP:0003645) | 4.59832745 |
9 | Hyperglycinuria (HP:0003108) | 4.32185268 |
10 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.16958169 |
11 | Abnormality of glycine metabolism (HP:0010895) | 4.16958169 |
12 | Ketosis (HP:0001946) | 4.14219920 |
13 | Hyperammonemia (HP:0001987) | 4.06942694 |
14 | Hyperlipoproteinemia (HP:0010980) | 4.02540640 |
15 | Mesangial abnormality (HP:0001966) | 4.02442959 |
16 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.82425887 |
17 | Complement deficiency (HP:0004431) | 3.78990700 |
18 | Increased hepatocellular lipid droplets (HP:0006565) | 3.55403742 |
19 | Hypoglycemic coma (HP:0001325) | 3.47683582 |
20 | Renal Fanconi syndrome (HP:0001994) | 3.45227989 |
21 | Hypolipoproteinemia (HP:0010981) | 3.41109052 |
22 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.36995229 |
23 | Delayed CNS myelination (HP:0002188) | 3.32633756 |
24 | Fat malabsorption (HP:0002630) | 3.26804238 |
25 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.22283016 |
26 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.19858582 |
27 | Ketoacidosis (HP:0001993) | 3.17600380 |
28 | Joint hemorrhage (HP:0005261) | 3.12457808 |
29 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.10506549 |
30 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.10172802 |
31 | Acute necrotizing encephalopathy (HP:0006965) | 3.07698228 |
32 | Malnutrition (HP:0004395) | 3.06998364 |
33 | Increased CSF lactate (HP:0002490) | 3.06737840 |
34 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.05133522 |
35 | Abnormality of the common coagulation pathway (HP:0010990) | 3.05011186 |
36 | Dicarboxylic aciduria (HP:0003215) | 3.04985156 |
37 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.04985156 |
38 | Abnormality of complement system (HP:0005339) | 3.04233727 |
39 | Epidermoid cyst (HP:0200040) | 3.01214617 |
40 | Congenital stationary night blindness (HP:0007642) | 2.93827536 |
41 | Hypoalphalipoproteinemia (HP:0003233) | 2.88607516 |
42 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.87567052 |
43 | Hyperbilirubinemia (HP:0002904) | 2.87159597 |
44 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.84826157 |
45 | Abnormal hemoglobin (HP:0011902) | 2.82835827 |
46 | Hypercholesterolemia (HP:0003124) | 2.82325007 |
47 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.81557943 |
48 | Gout (HP:0001997) | 2.76674965 |
49 | Exertional dyspnea (HP:0002875) | 2.75877770 |
50 | Hepatic necrosis (HP:0002605) | 2.73793781 |
51 | Cerebral edema (HP:0002181) | 2.73769549 |
52 | Attenuation of retinal blood vessels (HP:0007843) | 2.72529470 |
53 | Acanthocytosis (HP:0001927) | 2.70161467 |
54 | Late onset (HP:0003584) | 2.70076705 |
55 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.69345530 |
56 | Abnormality of nucleobase metabolism (HP:0010932) | 2.68177408 |
57 | Increased muscle lipid content (HP:0009058) | 2.67202551 |
58 | Metabolic acidosis (HP:0001942) | 2.63675148 |
59 | Macrocytic anemia (HP:0001972) | 2.63652660 |
60 | Lethargy (HP:0001254) | 2.61204452 |
61 | Abnormality of purine metabolism (HP:0004352) | 2.59853034 |
62 | Generalized aminoaciduria (HP:0002909) | 2.58867345 |
63 | Abnormality of serum amino acid levels (HP:0003112) | 2.55630441 |
64 | Glycosuria (HP:0003076) | 2.51689592 |
65 | Abnormality of urine glucose concentration (HP:0011016) | 2.51689592 |
66 | Hyperphosphaturia (HP:0003109) | 2.50592652 |
67 | Reduced antithrombin III activity (HP:0001976) | 2.48609208 |
68 | Conjugated hyperbilirubinemia (HP:0002908) | 2.47803351 |
69 | Increased serum lactate (HP:0002151) | 2.38804646 |
70 | Progressive macrocephaly (HP:0004481) | 2.37638260 |
71 | Lactic acidosis (HP:0003128) | 2.37396810 |
72 | Abnormality of the intrinsic pathway (HP:0010989) | 2.37046282 |
73 | Myocardial infarction (HP:0001658) | 2.35142244 |
74 | Vomiting (HP:0002013) | 2.34759747 |
75 | Hepatocellular necrosis (HP:0001404) | 2.30714343 |
76 | Reticulocytopenia (HP:0001896) | 2.30190135 |
77 | Abnormality of methionine metabolism (HP:0010901) | 2.30159124 |
78 | Increased intramyocellular lipid droplets (HP:0012240) | 2.29509902 |
79 | Abnormality of renal resorption (HP:0011038) | 2.29189654 |
80 | Hemorrhage of the eye (HP:0011885) | 2.27369987 |
81 | Abnormality of the Achilles tendon (HP:0005109) | 2.26749350 |
82 | Ileus (HP:0002595) | 2.23245463 |
83 | Lipid accumulation in hepatocytes (HP:0006561) | 2.21539254 |
84 | Chronic hepatic failure (HP:0100626) | 2.21383160 |
85 | Decreased central vision (HP:0007663) | 2.21204894 |
86 | Type I transferrin isoform profile (HP:0003642) | 2.20172567 |
87 | Optic disc pallor (HP:0000543) | 2.16681649 |
88 | Steatorrhea (HP:0002570) | 2.16327547 |
89 | Menorrhagia (HP:0000132) | 2.16128530 |
90 | Ragged-red muscle fibers (HP:0003200) | 2.15913348 |
91 | Acute encephalopathy (HP:0006846) | 2.15476027 |
92 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.15012432 |
93 | Spontaneous abortion (HP:0005268) | 2.14464865 |
94 | Exercise intolerance (HP:0003546) | 2.13888282 |
95 | Skin nodule (HP:0200036) | 2.12746158 |
96 | Systemic lupus erythematosus (HP:0002725) | 2.11235510 |
97 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.10677597 |
98 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.10638340 |
99 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.10638340 |
100 | Poikilocytosis (HP:0004447) | 2.10562254 |
101 | Stomatitis (HP:0010280) | 2.08558422 |
102 | Progressive microcephaly (HP:0000253) | 2.08016753 |
103 | Abnormal urine phosphate concentration (HP:0012599) | 2.06292613 |
104 | Hypophosphatemic rickets (HP:0004912) | 2.05325443 |
105 | Hepatocellular carcinoma (HP:0001402) | 2.05307885 |
106 | Microretrognathia (HP:0000308) | 2.05072938 |
107 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.04857791 |
108 | Abnormal ciliary motility (HP:0012262) | 2.04612495 |
109 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.03463378 |
110 | Molar tooth sign on MRI (HP:0002419) | 2.02509377 |
111 | Abnormality of midbrain morphology (HP:0002418) | 2.02509377 |
112 | Absent/shortened dynein arms (HP:0200106) | 2.01699464 |
113 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.01699464 |
114 | Nephronophthisis (HP:0000090) | 2.01189204 |
115 | Pancreatitis (HP:0001733) | 2.00338418 |
116 | Vascular calcification (HP:0004934) | 2.00314929 |
117 | Abnormal gallbladder morphology (HP:0012437) | 2.00286344 |
118 | Cholelithiasis (HP:0001081) | 1.99917486 |
119 | Large eyes (HP:0001090) | 1.99731123 |
120 | 3-Methylglutaconic aciduria (HP:0003535) | 1.99481828 |
121 | Proximal tubulopathy (HP:0000114) | 1.98092134 |
122 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.97798618 |
123 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.97798618 |
124 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.95234929 |
125 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.95234929 |
126 | Abnormal protein glycosylation (HP:0012346) | 1.95234929 |
127 | Abnormal glycosylation (HP:0012345) | 1.95234929 |
128 | Facial diplegia (HP:0001349) | 1.93402656 |
129 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.93195020 |
130 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.93195020 |
131 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.93195020 |
132 | Neonatal onset (HP:0003623) | 1.92180753 |
133 | Testicular atrophy (HP:0000029) | 1.90297334 |
134 | True hermaphroditism (HP:0010459) | 1.88750125 |
135 | Abnormality of dental color (HP:0011073) | 1.88406559 |
136 | Esophageal varix (HP:0002040) | 1.87819250 |
137 | Abnormality of reticulocytes (HP:0004312) | 1.86427582 |
138 | Polycythemia (HP:0001901) | 1.85736637 |
139 | Respiratory difficulties (HP:0002880) | 1.85222974 |
140 | Petechiae (HP:0000967) | 1.85063855 |
141 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.84224215 |
142 | Hydroxyprolinuria (HP:0003080) | 1.84072413 |
143 | Abnormality of proline metabolism (HP:0010907) | 1.84072413 |
144 | Irritability (HP:0000737) | 1.83830455 |
145 | Mitochondrial inheritance (HP:0001427) | 1.83357233 |
146 | Abnormality of the gallbladder (HP:0005264) | 1.83229479 |
147 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.82899293 |
148 | Pancreatic cysts (HP:0001737) | 1.82655054 |
149 | Increased serum ferritin (HP:0003281) | 1.82571889 |
150 | Spastic diplegia (HP:0001264) | 1.82014719 |
151 | Myositis (HP:0100614) | 1.80901704 |
152 | Impaired platelet aggregation (HP:0003540) | 1.80575114 |
153 | Abnormal platelet function (HP:0011869) | 1.80575114 |
154 | Alkalosis (HP:0001948) | 1.80295882 |
155 | Nausea (HP:0002018) | 1.80267413 |
156 | Glomerulonephritis (HP:0000099) | 1.80151919 |
157 | Cerebral palsy (HP:0100021) | 1.79776759 |
158 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.79560127 |
159 | Abnormal albumin level (HP:0012116) | 1.78935596 |
160 | Hypoalbuminemia (HP:0003073) | 1.78935596 |
161 | Pallor (HP:0000980) | 1.78924530 |
162 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.78916457 |
163 | Abnormality of alanine metabolism (HP:0010916) | 1.78916457 |
164 | Hyperalaninemia (HP:0003348) | 1.78916457 |
165 | Abnormal number of erythroid precursors (HP:0012131) | 1.78264644 |
166 | CNS demyelination (HP:0007305) | 1.76335806 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TLK1 | 7.13427121 |
2 | BCKDK | 4.03604423 |
3 | ERN1 | 3.59190581 |
4 | TRIB3 | 3.17903659 |
5 | MAP3K10 | 3.12325489 |
6 | PKN2 | 2.85257229 |
7 | VRK2 | 2.62736315 |
8 | FGFR4 | 2.49981128 |
9 | TESK2 | 2.44560699 |
10 | NME2 | 2.44281697 |
11 | SIK1 | 2.33146896 |
12 | MUSK | 2.29258751 |
13 | FLT3 | 2.17000723 |
14 | ACVR1B | 2.02081120 |
15 | TXK | 1.97492730 |
16 | CDK19 | 1.97205492 |
17 | TAOK3 | 1.95724561 |
18 | LMTK2 | 1.76731034 |
19 | ADRBK2 | 1.69180732 |
20 | GRK1 | 1.64703354 |
21 | PIM2 | 1.62201420 |
22 | PIK3CG | 1.62153558 |
23 | WNK4 | 1.60113844 |
24 | PINK1 | 1.57712629 |
25 | DAPK3 | 1.51713827 |
26 | INSRR | 1.45850157 |
27 | MST1R | 1.45411607 |
28 | MAP4K2 | 1.44357540 |
29 | GRK6 | 1.41432320 |
30 | TESK1 | 1.40545453 |
31 | MAPK11 | 1.39153717 |
32 | LRRK2 | 1.38965366 |
33 | BMPR1B | 1.34262670 |
34 | MAP3K11 | 1.33242270 |
35 | TNK2 | 1.32092813 |
36 | PTK6 | 1.25318241 |
37 | TTN | 1.24532153 |
38 | ARAF | 1.21100374 |
39 | OXSR1 | 1.19830206 |
40 | MAP3K7 | 1.16541175 |
41 | CAMKK2 | 1.14845459 |
42 | MAPK15 | 1.13144421 |
43 | TYK2 | 1.12962509 |
44 | EPHB1 | 1.10228360 |
45 | DYRK1B | 1.10103420 |
46 | ZAK | 1.07632197 |
47 | NME1 | 1.07521963 |
48 | TBK1 | 1.06182886 |
49 | KDR | 1.04071426 |
50 | MAP4K1 | 1.03275881 |
51 | EEF2K | 1.02946702 |
52 | ADRBK1 | 1.02599649 |
53 | IRAK3 | 1.01828480 |
54 | NEK9 | 1.01621327 |
55 | SIK2 | 1.00502487 |
56 | IRAK4 | 0.98572340 |
57 | PDK3 | 0.95722110 |
58 | PDK4 | 0.95722110 |
59 | TGFBR2 | 0.91896237 |
60 | MYLK | 0.91861453 |
61 | LIMK1 | 0.91000187 |
62 | PRKAA2 | 0.89750406 |
63 | MAP2K3 | 0.88649844 |
64 | MAP3K12 | 0.87198801 |
65 | EPHB2 | 0.86903138 |
66 | BTK | 0.86669108 |
67 | SYK | 0.85731319 |
68 | ILK | 0.79502305 |
69 | JAK2 | 0.78947950 |
70 | IRAK1 | 0.76894141 |
71 | ICK | 0.76629078 |
72 | ERBB4 | 0.76409522 |
73 | RIPK4 | 0.76054284 |
74 | TAOK1 | 0.74752949 |
75 | BLK | 0.74538468 |
76 | MAP2K2 | 0.73469410 |
77 | PDK2 | 0.73151316 |
78 | PTK2B | 0.70832777 |
79 | EPHA2 | 0.69762239 |
80 | CCNB1 | 0.69154826 |
81 | RPS6KA4 | 0.69089997 |
82 | ZAP70 | 0.67930799 |
83 | SIK3 | 0.67031965 |
84 | RIPK1 | 0.65810850 |
85 | FRK | 0.65247444 |
86 | LYN | 0.64637582 |
87 | ABL2 | 0.63719014 |
88 | RPS6KA6 | 0.60196842 |
89 | IKBKE | 0.59841143 |
90 | ERBB2 | 0.58901915 |
91 | MATK | 0.57934560 |
92 | RPS6KA2 | 0.55236438 |
93 | PDPK1 | 0.55033118 |
94 | PRKG2 | 0.54794650 |
95 | CSF1R | 0.54462316 |
96 | TEC | 0.54069373 |
97 | BRAF | 0.53844325 |
98 | PRKCI | 0.53593377 |
99 | RPS6KA5 | 0.51534316 |
100 | CDK4 | 0.50982716 |
101 | DAPK1 | 0.50962702 |
102 | CAMK1D | 0.50644566 |
103 | STK39 | 0.49399607 |
104 | PRKD1 | 0.49274201 |
105 | DYRK3 | 0.49104761 |
106 | STK10 | 0.48119930 |
107 | PRKD2 | 0.46937770 |
108 | FES | 0.46834501 |
109 | MAPK4 | 0.45712386 |
110 | MAPK12 | 0.45628618 |
111 | MAP2K6 | 0.45298929 |
112 | MAP3K8 | 0.44481313 |
113 | PTK2 | 0.44462711 |
114 | NLK | 0.44453893 |
115 | MAPKAPK3 | 0.43775226 |
116 | LCK | 0.43647884 |
117 | MAP2K7 | 0.43468924 |
118 | NUAK1 | 0.43374316 |
119 | AURKA | 0.43286396 |
120 | PAK1 | 0.42815844 |
121 | DYRK2 | 0.42555117 |
122 | RPS6KC1 | 0.42308593 |
123 | RPS6KL1 | 0.42308593 |
124 | KIT | 0.41311122 |
125 | CSK | 0.41162018 |
126 | JAK1 | 0.40932578 |
127 | TRIM28 | 0.39613855 |
128 | CSNK1G3 | 0.38192579 |
129 | PKN1 | 0.38069094 |
130 | STK4 | 0.37520068 |
131 | MAP3K1 | 0.37492451 |
132 | TIE1 | 0.36767411 |
133 | HIPK2 | 0.36224112 |
134 | PRKACA | 0.35965471 |
135 | PRKCD | 0.35172776 |
136 | PRKCQ | 0.35053982 |
137 | STK16 | 0.34396993 |
138 | RPS6KB2 | 0.34335264 |
139 | MAP3K3 | 0.33789230 |
140 | MAP3K14 | 0.33725995 |
141 | PRKCA | 0.33276944 |
142 | IRAK2 | 0.32854012 |
143 | PHKG1 | 0.31387731 |
144 | PHKG2 | 0.31387731 |
145 | MAP2K4 | 0.29779442 |
146 | EPHA3 | 0.28791579 |
147 | ITK | 0.28201369 |
148 | CAMK4 | 0.27610951 |
149 | MTOR | 0.26918625 |
150 | NEK2 | 0.26717128 |
151 | IKBKB | 0.26524060 |
152 | PDK1 | 0.25800094 |
153 | CDC42BPA | 0.25728424 |
154 | CDK9 | 0.25674290 |
155 | DAPK2 | 0.23906201 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.95608457 |
2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.18079269 |
3 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.80247659 |
4 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.72611034 |
5 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.71855051 |
6 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.67631562 |
7 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.55199308 |
8 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.53481420 |
9 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.43367165 |
10 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.41013745 |
11 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.39346750 |
12 | Sulfur relay system_Homo sapiens_hsa04122 | 2.33665009 |
13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.30735564 |
14 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.15567612 |
15 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.08661266 |
16 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.08158232 |
17 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.07744231 |
18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.07327327 |
19 | Peroxisome_Homo sapiens_hsa04146 | 2.00760366 |
20 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.95867198 |
21 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.94774145 |
22 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.93304878 |
23 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.91844983 |
24 | Ribosome_Homo sapiens_hsa03010 | 1.91460797 |
25 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.88732086 |
26 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.81496681 |
27 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.81234445 |
28 | Histidine metabolism_Homo sapiens_hsa00340 | 1.71059063 |
29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.70621288 |
30 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.69280301 |
31 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.66997734 |
32 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.66498463 |
33 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.65565562 |
34 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.60645148 |
35 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.59909951 |
36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.59042684 |
37 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.56588808 |
38 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.56499368 |
39 | Proteasome_Homo sapiens_hsa03050 | 1.55138879 |
40 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.53013278 |
41 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.45248476 |
42 | Bile secretion_Homo sapiens_hsa04976 | 1.44247383 |
43 | Retinol metabolism_Homo sapiens_hsa00830 | 1.43707230 |
44 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.40713635 |
45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.37233264 |
46 | Carbon metabolism_Homo sapiens_hsa01200 | 1.37096173 |
47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.35032194 |
48 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.29684346 |
49 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.26621660 |
50 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.25518301 |
51 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.24222890 |
52 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.21266838 |
53 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.19840848 |
54 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.15104513 |
55 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.14544873 |
56 | ABC transporters_Homo sapiens_hsa02010 | 1.13163012 |
57 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.09364766 |
58 | Lysine degradation_Homo sapiens_hsa00310 | 1.08207608 |
59 | Base excision repair_Homo sapiens_hsa03410 | 1.07944118 |
60 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.04898666 |
61 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.02720867 |
62 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.01798960 |
63 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.00052116 |
64 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.99496954 |
65 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.99147363 |
66 | RNA polymerase_Homo sapiens_hsa03020 | 0.97567890 |
67 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.96916756 |
68 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.95261600 |
69 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.91578130 |
70 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.89959653 |
71 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.89402218 |
72 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.88794055 |
73 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.85486178 |
74 | Phototransduction_Homo sapiens_hsa04744 | 0.83335332 |
75 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.82332922 |
76 | Lysosome_Homo sapiens_hsa04142 | 0.82164761 |
77 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.81406093 |
78 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.80750014 |
79 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.79418361 |
80 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.77503820 |
81 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.71772546 |
82 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.71540488 |
83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.70785149 |
84 | Parkinsons disease_Homo sapiens_hsa05012 | 0.70169434 |
85 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.70113460 |
86 | Asthma_Homo sapiens_hsa05310 | 0.69423815 |
87 | Allograft rejection_Homo sapiens_hsa05330 | 0.66322248 |
88 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.63857531 |
89 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.62305007 |
90 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.61495329 |
91 | Galactose metabolism_Homo sapiens_hsa00052 | 0.59237586 |
92 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.57804458 |
93 | Metabolic pathways_Homo sapiens_hsa01100 | 0.57704577 |
94 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.52032772 |
95 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49286240 |
96 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.49009904 |
97 | Alzheimers disease_Homo sapiens_hsa05010 | 0.47544937 |
98 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.47186661 |
99 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.45471111 |
100 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.45041087 |
101 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.44916790 |
102 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.43667930 |
103 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.42048182 |
104 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41103019 |
105 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.39734315 |
106 | Insulin resistance_Homo sapiens_hsa04931 | 0.38285477 |
107 | Huntingtons disease_Homo sapiens_hsa05016 | 0.34687613 |
108 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.33753381 |
109 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.31544686 |
110 | Bladder cancer_Homo sapiens_hsa05219 | 0.30247663 |
111 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.28980175 |
112 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.19589725 |
113 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.18875345 |
114 | Protein export_Homo sapiens_hsa03060 | 0.16714072 |
115 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.15913779 |
116 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.15290191 |
117 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.13965830 |
118 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.10888722 |
119 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.09220401 |
120 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.06934114 |
121 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.06422437 |
122 | Other glycan degradation_Homo sapiens_hsa00511 | 0.05148225 |
123 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.04513190 |
124 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.01846549 |
125 | Mineral absorption_Homo sapiens_hsa04978 | 0.01351829 |
126 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.01149883 |
127 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.0114274 |
128 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | -0.0084536 |
129 | Prion diseases_Homo sapiens_hsa05020 | -0.0073051 |
130 | Protein digestion and absorption_Homo sapiens_hsa04974 | -0.0002888 |