OCIAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.17587696
2chaperone-mediated protein transport (GO:0072321)4.91544126
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.81430569
4protein neddylation (GO:0045116)4.78547252
5regulation of cellular amino acid metabolic process (GO:0006521)4.61930956
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.61746441
7mitochondrial respiratory chain complex assembly (GO:0033108)4.60836535
8regulation of mitochondrial translation (GO:0070129)4.36100294
9detection of calcium ion (GO:0005513)4.35346952
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.30565119
11termination of RNA polymerase III transcription (GO:0006386)4.17124221
12transcription elongation from RNA polymerase III promoter (GO:0006385)4.17124221
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.16709121
14negative regulation of ligase activity (GO:0051352)4.16596000
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.16596000
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.16171018
17establishment of integrated proviral latency (GO:0075713)4.15429935
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.09546555
19NADH dehydrogenase complex assembly (GO:0010257)4.09546555
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.09546555
21water-soluble vitamin biosynthetic process (GO:0042364)4.09096003
22cytochrome complex assembly (GO:0017004)4.08682596
23respiratory chain complex IV assembly (GO:0008535)4.07575584
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.04244451
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.04244451
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.04244451
27synaptic vesicle exocytosis (GO:0016079)4.04176406
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.02948646
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.02948646
30vocalization behavior (GO:0071625)3.96826592
31neuronal action potential propagation (GO:0019227)3.93580315
32protein maturation by protein folding (GO:0022417)3.88283208
33sequestering of actin monomers (GO:0042989)3.87637428
34establishment of viral latency (GO:0019043)3.87434967
35regulation of oxidative phosphorylation (GO:0002082)3.83240149
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.83028270
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.83028270
38regulation of synaptic vesicle exocytosis (GO:2000300)3.82465649
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.82019659
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.81687006
41DNA deamination (GO:0045006)3.79738958
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78673478
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78103919
44presynaptic membrane assembly (GO:0097105)3.76799098
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76115576
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.74752900
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73979399
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71468947
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.71468947
50regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69058784
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.65241594
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57009463
53regulation of synaptic vesicle transport (GO:1902803)3.56021603
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.52208197
55postsynaptic membrane organization (GO:0001941)3.49546989
56regulation of glutamate receptor signaling pathway (GO:1900449)3.48749825
57positive regulation of ligase activity (GO:0051351)3.47949144
58ribosomal large subunit biogenesis (GO:0042273)3.47457226
59pseudouridine synthesis (GO:0001522)3.46853516
60neuron cell-cell adhesion (GO:0007158)3.46516902
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.46295581
62glutamate secretion (GO:0014047)3.45903872
63ATP hydrolysis coupled proton transport (GO:0015991)3.45044299
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.45044299
65cullin deneddylation (GO:0010388)3.45034029
66serotonin metabolic process (GO:0042428)3.42814923
67protein deneddylation (GO:0000338)3.42449833
68protein targeting to mitochondrion (GO:0006626)3.41707360
69glutamate receptor signaling pathway (GO:0007215)3.41242908
70protein localization to synapse (GO:0035418)3.41115527
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40309715
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40028659
73regulation of cellular amine metabolic process (GO:0033238)3.39347087
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.37245819
75presynaptic membrane organization (GO:0097090)3.37172110
76female mating behavior (GO:0060180)3.36776932
77platelet dense granule organization (GO:0060155)3.35366894
78neuron-neuron synaptic transmission (GO:0007270)3.35124656
79synaptic transmission, glutamatergic (GO:0035249)3.34754232
80energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31541203
81ATP synthesis coupled proton transport (GO:0015986)3.31541203
82protein-cofactor linkage (GO:0018065)3.29767418
83rRNA modification (GO:0000154)3.29138541
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.28369148
85respiratory electron transport chain (GO:0022904)3.27128377
86long-term synaptic potentiation (GO:0060291)3.25745410
87DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.23926852
88establishment of protein localization to mitochondrion (GO:0072655)3.23124858
89protein localization to mitochondrion (GO:0070585)3.21955755
90electron transport chain (GO:0022900)3.20862056
91regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.14998339
92regulation of ubiquitin-protein transferase activity (GO:0051438)3.14085037
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.13412496
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11059786
95transferrin transport (GO:0033572)3.08581845
96positive regulation of neurotransmitter secretion (GO:0001956)3.07969716
97peptide hormone processing (GO:0016486)3.07697100
98cochlea development (GO:0090102)3.07072526
99regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.06745159
100primary amino compound metabolic process (GO:1901160)3.05842777
101regulation of type B pancreatic cell apoptotic process (GO:2000674)3.05422938
102mannosylation (GO:0097502)3.05237593
103negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04876108
104neurotransmitter-gated ion channel clustering (GO:0072578)3.02492799
105ribosomal small subunit assembly (GO:0000028)3.01860025
106regulation of ligase activity (GO:0051340)3.01768867
107regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01179601
108endocrine pancreas development (GO:0031018)3.00586613
109base-excision repair, AP site formation (GO:0006285)3.00538961
110long term synaptic depression (GO:0060292)3.00062485
111intracellular protein transmembrane import (GO:0044743)3.00039795
112regulation of catecholamine metabolic process (GO:0042069)2.99606327
113regulation of dopamine metabolic process (GO:0042053)2.99606327
114response to histamine (GO:0034776)2.99518314
115chemosensory behavior (GO:0007635)2.99146526
116positive regulation of cell cycle arrest (GO:0071158)2.98460814
117negative regulation of protein ubiquitination (GO:0031397)2.96286262
118innervation (GO:0060384)2.95050341
119DNA damage response, detection of DNA damage (GO:0042769)2.94026814
120regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93879196
121antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93573916
122proton transport (GO:0015992)2.93559580
123translation (GO:0006412)2.93444882
124regulation of vesicle fusion (GO:0031338)2.91747435
125ferric iron transport (GO:0015682)2.91677365
126trivalent inorganic cation transport (GO:0072512)2.91677365
127ATP biosynthetic process (GO:0006754)2.87300741
128neurotransmitter secretion (GO:0007269)2.86540939
129behavioral response to cocaine (GO:0048148)2.86470921
130hydrogen transport (GO:0006818)2.85928584
131purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85299397
132startle response (GO:0001964)2.84247874
133positive regulation of neurotransmitter transport (GO:0051590)2.81806147
134inner ear receptor cell development (GO:0060119)2.81685669
135positive regulation of membrane potential (GO:0045838)2.81575403
136regulation of female receptivity (GO:0045924)2.81410459
137regulation of neuronal synaptic plasticity (GO:0048168)2.81410096
138protein localization to Golgi apparatus (GO:0034067)2.80747213
139insulin secretion (GO:0030073)2.80694869
140purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.80678115
141protein complex biogenesis (GO:0070271)2.80034849
142membrane repolarization during action potential (GO:0086011)2.79448136
143regulation of synaptic plasticity (GO:0048167)2.79274892
144regulation of postsynaptic membrane potential (GO:0060078)2.78850692
145inner mitochondrial membrane organization (GO:0007007)2.78642108
1467-methylguanosine mRNA capping (GO:0006370)2.77871465
147synaptic vesicle endocytosis (GO:0048488)2.77102783
148negative regulation of amine transport (GO:0051953)2.75435257
149positive regulation of response to oxidative stress (GO:1902884)2.75408491
150positive regulation of cellular response to oxidative stress (GO:1900409)2.75408491
151negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.74530892
152cytidine deamination (GO:0009972)2.74142771
153cytidine metabolic process (GO:0046087)2.74142771
154cytidine catabolic process (GO:0006216)2.74142771
155metallo-sulfur cluster assembly (GO:0031163)2.74137496
156iron-sulfur cluster assembly (GO:0016226)2.74137496
157regulation of glutamate secretion (GO:0014048)2.72937701
158tRNA processing (GO:0008033)2.71016607
159cellular component biogenesis (GO:0044085)2.70862716
1607-methylguanosine RNA capping (GO:0009452)2.70410580
161RNA capping (GO:0036260)2.70410580
162deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69520124
163negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.69314078
164negative regulation of calcium ion transmembrane transport (GO:1903170)2.69314078
165fear response (GO:0042596)2.68581072
166mitochondrial transport (GO:0006839)2.68167292
167righting reflex (GO:0060013)2.67877634
168Golgi transport vesicle coating (GO:0048200)2.67733931
169COPI coating of Golgi vesicle (GO:0048205)2.67733931
170neuron recognition (GO:0008038)2.66588253
171negative regulation of cation channel activity (GO:2001258)2.66574228
172signal transduction in response to DNA damage (GO:0042770)2.66472088
173negative regulation of catecholamine secretion (GO:0033604)2.66434640
174regulation of insulin secretion (GO:0050796)2.65664117
175ribosome assembly (GO:0042255)2.65327173
176exploration behavior (GO:0035640)2.65259368
177long-term memory (GO:0007616)2.63480424
178positive regulation of exocytosis (GO:0045921)2.63002958
179locomotory exploration behavior (GO:0035641)2.62762022
180SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.61634341
181cotranslational protein targeting to membrane (GO:0006613)2.61256866
182regulation of neuron projection regeneration (GO:0070570)2.61133234
183regulation of axon regeneration (GO:0048679)2.61133234
184cobalamin metabolic process (GO:0009235)2.60120131
185GTP biosynthetic process (GO:0006183)2.59706466
186negative regulation of telomere maintenance (GO:0032205)2.59245250
187hydrogen ion transmembrane transport (GO:1902600)2.58787758
188purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58269345
1893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58269345
190membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57378109
191positive regulation of vesicle fusion (GO:0031340)2.57107393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61438795
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.30674330
3GABP_17652178_ChIP-ChIP_JURKAT_Human5.07994456
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.39337658
5GBX2_23144817_ChIP-Seq_PC3_Human4.31613212
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82017348
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.73874590
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.49893666
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45854475
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.37263718
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.18920504
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94299842
13ELK1_19687146_ChIP-ChIP_HELA_Human2.85270788
14* VDR_23849224_ChIP-Seq_CD4+_Human2.77527013
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75088192
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68099957
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65449215
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.55875779
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49390847
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.47751522
21REST_21632747_ChIP-Seq_MESCs_Mouse2.46560901
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40353209
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38538654
24FOXP3_21729870_ChIP-Seq_TREG_Human2.34685534
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24755115
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19414665
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19273328
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18746133
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17583008
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17294096
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16735651
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15013501
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13287866
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09566825
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05996304
36TAF15_26573619_Chip-Seq_HEK293_Human2.05601987
37MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02529039
38THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00069298
39* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99644798
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99547346
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98637395
42DCP1A_22483619_ChIP-Seq_HELA_Human1.97767996
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.97575474
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97540901
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95942774
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95942774
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.95710831
48VDR_22108803_ChIP-Seq_LS180_Human1.95145901
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94742972
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.90144320
51GABP_19822575_ChIP-Seq_HepG2_Human1.86645515
52P300_19829295_ChIP-Seq_ESCs_Human1.84879947
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83627065
54SMAD4_21799915_ChIP-Seq_A2780_Human1.81877125
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.80538270
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.80003168
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77654912
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.77516724
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77211645
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75764645
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73063179
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71663999
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.71363745
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71111823
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68606099
66* MYC_18940864_ChIP-ChIP_HL60_Human1.67006054
67FUS_26573619_Chip-Seq_HEK293_Human1.64967907
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63990421
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63397118
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.62903779
71DROSHA_22980978_ChIP-Seq_HELA_Human1.61599020
72TTF2_22483619_ChIP-Seq_HELA_Human1.60255225
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59146908
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58928284
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56099655
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55792056
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54710493
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52839711
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52423263
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52308153
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.52000975
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51475150
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51376503
84IGF1R_20145208_ChIP-Seq_DFB_Human1.50148724
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49223756
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48263005
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45191094
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.43669354
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41990866
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40349725
91AR_25329375_ChIP-Seq_VCAP_Human1.37490309
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37480475
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.35738623
94XRN2_22483619_ChIP-Seq_HELA_Human1.35321300
95ZNF274_21170338_ChIP-Seq_K562_Hela1.34861828
96BCAT_22108803_ChIP-Seq_LS180_Human1.33687616
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30177583
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27549709
99P53_22387025_ChIP-Seq_ESCs_Mouse1.26575616
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26507632
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26168974
102STAT3_23295773_ChIP-Seq_U87_Human1.24554290
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24400173
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24144065
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22776381
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21360516
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21311713
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18837233
109IRF1_19129219_ChIP-ChIP_H3396_Human1.18768930
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.18028038
111* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16966708
112TCF4_23295773_ChIP-Seq_U87_Human1.16898050
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16773566
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16661580
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16159944
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15658155
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.15619098
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.13548566
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12958476
120RUNX2_22187159_ChIP-Seq_PCA_Human1.12781070
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.12386278
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11862812
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11308532
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10801526
125FOXA1_25329375_ChIP-Seq_VCAP_Human1.10801526
126TP53_22573176_ChIP-Seq_HFKS_Human1.09734251
127PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09506632
128TP53_18474530_ChIP-ChIP_U2OS_Human1.08669478
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.08355366
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.07855903
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07808368
132EWS_26573619_Chip-Seq_HEK293_Human1.06957949
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06346493
134NANOG_16153702_ChIP-ChIP_HESCs_Human1.05827837
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05701818
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.05686432
137SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05276046
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05256794
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.04583067
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04354388
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03567914
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03418906
143AR_20517297_ChIP-Seq_VCAP_Human1.03356524
144JUN_21703547_ChIP-Seq_K562_Human1.02722897
145RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01122734
146EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00754945
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00564965
148KDM2B_26808549_Chip-Seq_REH_Human1.00493697
149RNF2_27304074_Chip-Seq_NSC_Mouse1.00426758
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00412204
151SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00369520
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.99975501
153PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99769961
154HTT_18923047_ChIP-ChIP_STHdh_Human0.99672886
155P300_18555785_Chip-Seq_ESCs_Mouse0.99279074
156TCF4_22108803_ChIP-Seq_LS180_Human0.99211672
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98498038
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98112367
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97495550
160ERG_21242973_ChIP-ChIP_JURKAT_Human0.97308949
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96356761
162NMYC_18555785_Chip-Seq_ESCs_Mouse0.96330080
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94459158
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.94354404
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.94055091
166CBP_20019798_ChIP-Seq_JUKART_Human0.93950478
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93950478
168TAL1_26923725_Chip-Seq_HPCs_Mouse0.92695430
169ER_23166858_ChIP-Seq_MCF-7_Human0.92601794
170NFE2_27457419_Chip-Seq_LIVER_Mouse0.92123300
171ELF5_23300383_ChIP-Seq_T47D_Human0.91961252
172SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88701821
173NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88443454
174KDM5A_27292631_Chip-Seq_BREAST_Human0.88338457
175NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87482635
176ERG_20517297_ChIP-Seq_VCAP_Human0.86556397
177HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85776345
178NANOG_20526341_ChIP-Seq_ESCs_Human0.84329126
179MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80184929
180BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78275781
181* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77709024
182NANOG_19829295_ChIP-Seq_ESCs_Human0.77540593
183SOX2_19829295_ChIP-Seq_ESCs_Human0.77540593
184NCOR_22424771_ChIP-Seq_293T_Human0.76931218
185FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76594848
186SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74773316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.65697937
2MP0004859_abnormal_synaptic_plasticity4.06298151
3MP0009780_abnormal_chondrocyte_physiolo3.07211943
4MP0003635_abnormal_synaptic_transmissio3.04259228
5MP0003806_abnormal_nucleotide_metabolis2.95038554
6MP0004270_analgesia2.85760512
7MP0010386_abnormal_urinary_bladder2.85140796
8MP0009745_abnormal_behavioral_response2.69361713
9MP0002837_dystrophic_cardiac_calcinosis2.66135710
10MP0002063_abnormal_learning/memory/cond2.56310170
11MP0004043_abnormal_pH_regulation2.53748016
12MP0003786_premature_aging2.51706251
13MP0003123_paternal_imprinting2.47577866
14MP0008877_abnormal_DNA_methylation2.44394803
15MP0001501_abnormal_sleep_pattern2.43395596
16MP0001968_abnormal_touch/_nociception2.40736927
17MP0005646_abnormal_pituitary_gland2.39478474
18MP0002736_abnormal_nociception_after2.37355218
19MP0002572_abnormal_emotion/affect_behav2.37200042
20MP0002822_catalepsy2.34227849
21MP0002909_abnormal_adrenal_gland2.33348964
22MP0008058_abnormal_DNA_repair2.27965894
23MP0003718_maternal_effect2.26296503
24MP0002876_abnormal_thyroid_physiology2.24536800
25MP0002064_seizures2.24286682
26MP0000013_abnormal_adipose_tissue2.19557660
27MP0005379_endocrine/exocrine_gland_phen2.18083491
28MP0002102_abnormal_ear_morphology2.17762239
29MP0003121_genomic_imprinting2.14357946
30MP0009697_abnormal_copulation2.11991945
31MP0003693_abnormal_embryo_hatching2.11574607
32MP0002272_abnormal_nervous_system2.06439035
33MP0008004_abnormal_stomach_pH2.04687339
34MP0003011_delayed_dark_adaptation1.99659920
35MP0003283_abnormal_digestive_organ1.91873423
36MP0001440_abnormal_grooming_behavior1.88186383
37MP0003787_abnormal_imprinting1.86483806
38MP0001188_hyperpigmentation1.83444560
39MP0006276_abnormal_autonomic_nervous1.83370987
40MP0002693_abnormal_pancreas_physiology1.82865171
41MP0002734_abnormal_mechanical_nocicepti1.81055959
42MP0006035_abnormal_mitochondrial_morpho1.79626263
43MP0008789_abnormal_olfactory_epithelium1.77555743
44MP0001529_abnormal_vocalization1.73768647
45MP0005645_abnormal_hypothalamus_physiol1.72244592
46MP0000678_abnormal_parathyroid_gland1.70785408
47MP0003879_abnormal_hair_cell1.69630134
48MP0001486_abnormal_startle_reflex1.68553688
49MP0009046_muscle_twitch1.68407133
50MP0002277_abnormal_respiratory_mucosa1.66605250
51MP0003186_abnormal_redox_activity1.62844641
52MP0001664_abnormal_digestion1.60652107
53MP0002735_abnormal_chemical_nociception1.57987378
54MP0004957_abnormal_blastocyst_morpholog1.57811808
55MP0001944_abnormal_pancreas_morphology1.56880958
56MP0002733_abnormal_thermal_nociception1.55466859
57MP0002067_abnormal_sensory_capabilities1.55402025
58MP0003195_calcinosis1.53504464
59MP0003315_abnormal_perineum_morphology1.51321709
60MP0002557_abnormal_social/conspecific_i1.46776349
61MP0005085_abnormal_gallbladder_physiolo1.40346786
62MP0001970_abnormal_pain_threshold1.40016920
63MP0005332_abnormal_amino_acid1.39913289
64MP0003252_abnormal_bile_duct1.38612413
65MP0009379_abnormal_foot_pigmentation1.37784180
66MP0002163_abnormal_gland_morphology1.35309030
67MP0004147_increased_porphyrin_level1.35271344
68MP0001984_abnormal_olfaction1.34330289
69MP0001765_abnormal_ion_homeostasis1.33927549
70MP0008875_abnormal_xenobiotic_pharmacok1.32150660
71MP0008007_abnormal_cellular_replicative1.30829551
72MP0003183_abnormal_peptide_metabolism1.30669810
73MP0005535_abnormal_body_temperature1.30267431
74MP0001502_abnormal_circadian_rhythm1.29800278
75MP0002138_abnormal_hepatobiliary_system1.27752885
76MP0001905_abnormal_dopamine_level1.27186847
77MP0005386_behavior/neurological_phenoty1.24983011
78MP0004924_abnormal_behavior1.24983011
79MP0001293_anophthalmia1.23150397
80MP0002938_white_spotting1.21471362
81MP0002139_abnormal_hepatobiliary_system1.20140052
82MP0003122_maternal_imprinting1.19354584
83MP0000647_abnormal_sebaceous_gland1.18001457
84MP0002078_abnormal_glucose_homeostasis1.12983238
85MP0005499_abnormal_olfactory_system1.12501822
86MP0005394_taste/olfaction_phenotype1.12501822
87MP0005365_abnormal_bile_salt1.11439968
88MP0002184_abnormal_innervation1.08343017
89MP0004133_heterotaxia1.07730795
90MP0003868_abnormal_feces_composition1.07543476
91MP0002653_abnormal_ependyma_morphology1.05312478
92MP0001764_abnormal_homeostasis1.04198953
93MP0006072_abnormal_retinal_apoptosis1.02346530
94MP0005423_abnormal_somatic_nervous1.01448470
95MP0008995_early_reproductive_senescence1.01370908
96MP0005367_renal/urinary_system_phenotyp1.00804349
97MP0000516_abnormal_urinary_system1.00804349
98MP0008932_abnormal_embryonic_tissue1.00677720
99MP0000462_abnormal_digestive_system0.99455307
100MP0000631_abnormal_neuroendocrine_gland0.99156490
101MP0003329_amyloid_beta_deposits0.97976783
102MP0010094_abnormal_chromosome_stability0.97858867
103MP0002877_abnormal_melanocyte_morpholog0.97777231
104MP0002069_abnormal_eating/drinking_beha0.95678118
105MP0001666_abnormal_nutrient_absorption0.95256586
106MP0004742_abnormal_vestibular_system0.94987074
107MP0008872_abnormal_physiological_respon0.94387205
108MP0002066_abnormal_motor_capabilities/c0.94213237
109MP0003953_abnormal_hormone_level0.92890204
110MP0003941_abnormal_skin_development0.91554191
111MP0002751_abnormal_autonomic_nervous0.90591827
112MP0005360_urolithiasis0.89623661
113MP0004264_abnormal_extraembryonic_tissu0.89396485
114MP0005551_abnormal_eye_electrophysiolog0.88676829
115MP0005636_abnormal_mineral_homeostasis0.88305698
116MP0000358_abnormal_cell_content/0.87063350
117MP0000538_abnormal_urinary_bladder0.86750628
118MP0006292_abnormal_olfactory_placode0.86655760
119MP0003633_abnormal_nervous_system0.86566342
120MP0008569_lethality_at_weaning0.85140383
121MP0005084_abnormal_gallbladder_morpholo0.85037673
122MP0004811_abnormal_neuron_physiology0.84909337
123MP0005253_abnormal_eye_physiology0.84021695
124MP0000427_abnormal_hair_cycle0.83443199
125MP0005395_other_phenotype0.81934437
126MP0000955_abnormal_spinal_cord0.81673682
127MP0000778_abnormal_nervous_system0.81518683
128MP0003119_abnormal_digestive_system0.81314725
129MP0002638_abnormal_pupillary_reflex0.80918049
130MP0005075_abnormal_melanosome_morpholog0.80718200
131MP0005220_abnormal_exocrine_pancreas0.80473007
132MP0002282_abnormal_trachea_morphology0.80066744
133MP0004142_abnormal_muscle_tone0.78888450
134MP0003638_abnormal_response/metabolism_0.76940941
135MP0009643_abnormal_urine_homeostasis0.76903086
136MP0002234_abnormal_pharynx_morphology0.76549968
137MP0001963_abnormal_hearing_physiology0.75986928
138MP0006036_abnormal_mitochondrial_physio0.75737815
139MP0002882_abnormal_neuron_morphology0.74980859
140MP0004145_abnormal_muscle_electrophysio0.74570660
141MP0005409_darkened_coat_color0.74056991
142MP0002229_neurodegeneration0.73984463
143MP0005266_abnormal_metabolism0.72990027
144MP0001485_abnormal_pinna_reflex0.72600008
145MP0004484_altered_response_of0.72344867
146MP0001986_abnormal_taste_sensitivity0.72105222
147MP0000230_abnormal_systemic_arterial0.71552655
148MP0003866_abnormal_defecation0.71195385
149MP0003950_abnormal_plasma_membrane0.71167980
150MP0004019_abnormal_vitamin_homeostasis0.70931842
151MP0005410_abnormal_fertilization0.68590054
152MP0001756_abnormal_urination0.67858441
153MP0001919_abnormal_reproductive_system0.67394191
154MP0000762_abnormal_tongue_morphology0.67114013
155MP0001853_heart_inflammation0.66327708
156MP0008775_abnormal_heart_ventricle0.65143359
157MP0002233_abnormal_nose_morphology0.64374933
158MP0000579_abnormal_nail_morphology0.64190251
159MP0002210_abnormal_sex_determination0.63956661

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.18842138
2Visual hallucinations (HP:0002367)4.30859034
3Hyperventilation (HP:0002883)4.25559967
4Acute necrotizing encephalopathy (HP:0006965)4.22355345
5Abnormal mitochondria in muscle tissue (HP:0008316)4.05085164
6Atonic seizures (HP:0010819)4.03585195
7Epileptic encephalopathy (HP:0200134)3.93690058
8Symptomatic seizures (HP:0011145)3.76586165
9Hyperinsulinemic hypoglycemia (HP:0000825)3.70664309
10Decreased circulating renin level (HP:0003351)3.68554169
11Progressive macrocephaly (HP:0004481)3.65548360
12Acute encephalopathy (HP:0006846)3.65219705
13Hypoglycemic seizures (HP:0002173)3.62861793
14Mitochondrial inheritance (HP:0001427)3.62853199
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.56617273
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.56583559
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.56583559
18Absence seizures (HP:0002121)3.49383332
19Febrile seizures (HP:0002373)3.47373811
20Methylmalonic aciduria (HP:0012120)3.40126892
21Focal seizures (HP:0007359)3.35971020
22Methylmalonic acidemia (HP:0002912)3.34517941
233-Methylglutaconic aciduria (HP:0003535)3.09435080
24Dialeptic seizures (HP:0011146)3.09098245
25Increased CSF lactate (HP:0002490)3.05663901
26Epileptiform EEG discharges (HP:0011182)3.05254143
27Increased serum lactate (HP:0002151)2.94960730
28Generalized tonic-clonic seizures (HP:0002069)2.91318759
29Congenital, generalized hypertrichosis (HP:0004540)2.89157908
30Hepatocellular necrosis (HP:0001404)2.88055352
31Hyperactive renin-angiotensin system (HP:0000841)2.84836226
32Conjugated hyperbilirubinemia (HP:0002908)2.83562753
33Hepatic necrosis (HP:0002605)2.83161728
34Type I transferrin isoform profile (HP:0003642)2.81301027
35Ketoacidosis (HP:0001993)2.81202627
36Myokymia (HP:0002411)2.80226939
37Hypoglycemic coma (HP:0001325)2.75456295
38EEG with generalized epileptiform discharges (HP:0011198)2.73445727
39Oral leukoplakia (HP:0002745)2.68013703
40Anxiety (HP:0000739)2.66291340
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64959017
42Exertional dyspnea (HP:0002875)2.61346399
43Delayed CNS myelination (HP:0002188)2.60910258
44Lethargy (HP:0001254)2.56185779
45Ventricular fibrillation (HP:0001663)2.54847356
46Pheochromocytoma (HP:0002666)2.54609924
47Pancreatic cysts (HP:0001737)2.52631121
48Abnormality of midbrain morphology (HP:0002418)2.51755794
49Molar tooth sign on MRI (HP:0002419)2.51755794
50Hypsarrhythmia (HP:0002521)2.51158054
51Abnormal number of erythroid precursors (HP:0012131)2.46783451
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.45376765
53Aplasia/hypoplasia of the uterus (HP:0008684)2.41540574
54Progressive cerebellar ataxia (HP:0002073)2.41284708
55Sparse eyelashes (HP:0000653)2.40332495
56Cerebral edema (HP:0002181)2.39937851
57Optic disc pallor (HP:0000543)2.38499569
58Hypothermia (HP:0002045)2.37750556
59Pancreatic fibrosis (HP:0100732)2.37507545
60Reduced antithrombin III activity (HP:0001976)2.37183552
61Medial flaring of the eyebrow (HP:0010747)2.34444161
62Increased hepatocellular lipid droplets (HP:0006565)2.34165815
63Hyperglycemia (HP:0003074)2.32569322
64Amblyopia (HP:0000646)2.32064535
65True hermaphroditism (HP:0010459)2.30657062
66Lipid accumulation in hepatocytes (HP:0006561)2.30344104
67Hyperglycinemia (HP:0002154)2.30282576
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.30260652
69Aplastic anemia (HP:0001915)2.29579736
70Abnormality of cells of the erythroid lineage (HP:0012130)2.27287239
71Abnormality of vitamin B metabolism (HP:0004340)2.26868461
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25846855
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25448242
74Abnormal protein N-linked glycosylation (HP:0012347)2.25448242
75Abnormal protein glycosylation (HP:0012346)2.25448242
76Abnormal glycosylation (HP:0012345)2.25448242
77Neuroendocrine neoplasm (HP:0100634)2.24981865
78Adrenal hypoplasia (HP:0000835)2.22796781
79Gait imbalance (HP:0002141)2.22433048
80Dysautonomia (HP:0002459)2.21439058
81Broad-based gait (HP:0002136)2.21145278
82Congenital primary aphakia (HP:0007707)2.20794221
83Insulin-resistant diabetes mellitus (HP:0000831)2.20051167
84Leukodystrophy (HP:0002415)2.19964221
85Agitation (HP:0000713)2.18205649
86Lactic acidosis (HP:0003128)2.16611393
87Abnormality of renin-angiotensin system (HP:0000847)2.16511976
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16297360
89Delusions (HP:0000746)2.16083197
90Abnormality of serum amino acid levels (HP:0003112)2.15843269
91Pancytopenia (HP:0001876)2.15665106
92Sclerocornea (HP:0000647)2.12913998
93Syncope (HP:0001279)2.12580450
94Hyperphosphaturia (HP:0003109)2.12033407
95Dicarboxylic aciduria (HP:0003215)2.10939265
96Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10939265
97Macrocytic anemia (HP:0001972)2.08459748
98Renal Fanconi syndrome (HP:0001994)2.08207404
99Abnormality of methionine metabolism (HP:0010901)2.08066601
100Testicular atrophy (HP:0000029)2.07796471
101Respiratory difficulties (HP:0002880)2.07209683
102Congenital sensorineural hearing impairment (HP:0008527)2.06765923
103Nephrogenic diabetes insipidus (HP:0009806)2.05168244
104Hyperkalemia (HP:0002153)2.04883712
105Protruding tongue (HP:0010808)2.04028609
106Cerebral inclusion bodies (HP:0100314)2.03594329
107Abnormality of alanine metabolism (HP:0010916)2.03398963
108Hyperalaninemia (HP:0003348)2.03398963
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03398963
110Abnormality of the labia minora (HP:0012880)2.03274796
111Hydroureter (HP:0000072)2.03142521
112Palpitations (HP:0001962)2.02204640
113Colon cancer (HP:0003003)2.01356058
114Glycosuria (HP:0003076)2.01087328
115Abnormality of urine glucose concentration (HP:0011016)2.01087328
116CNS demyelination (HP:0007305)2.00580328
117Increased intramyocellular lipid droplets (HP:0012240)1.97485362
118Generalized aminoaciduria (HP:0002909)1.97064329
119Exercise intolerance (HP:0003546)1.96070200
120Nephronophthisis (HP:0000090)1.95257739
121Generalized hypopigmentation of hair (HP:0011358)1.94700076
122Excessive salivation (HP:0003781)1.94415691
123Drooling (HP:0002307)1.94415691
124Truncal ataxia (HP:0002078)1.93098225
125Depression (HP:0000716)1.92319903
126Reticulocytopenia (HP:0001896)1.91543062
127Abnormality of renal resorption (HP:0011038)1.89243513
128Hypoplasia of the uterus (HP:0000013)1.89222652
129Respiratory failure (HP:0002878)1.89079179
130Blue irides (HP:0000635)1.87878395
131Oligomenorrhea (HP:0000876)1.85993849
132Increased serum pyruvate (HP:0003542)1.83812336
133Ketosis (HP:0001946)1.83625763
134Onycholysis (HP:0001806)1.82949597
135Hypokalemia (HP:0002900)1.82745346
136Abnormal pancreas size (HP:0012094)1.81792949
137Poor eye contact (HP:0000817)1.80859168
138Prolonged partial thromboplastin time (HP:0003645)1.80489099
139Impaired smooth pursuit (HP:0007772)1.78990850
140X-linked dominant inheritance (HP:0001423)1.78441259
141Psychosis (HP:0000709)1.77883811
142Late onset (HP:0003584)1.77620505
143IgG deficiency (HP:0004315)1.77202252
144Abnormality of placental membranes (HP:0011409)1.76244475
145Amniotic constriction ring (HP:0009775)1.76244475
146Gout (HP:0001997)1.75954793
147Poor suck (HP:0002033)1.74436657
148Bradykinesia (HP:0002067)1.70893029
149Resting tremor (HP:0002322)1.70437004
150Abnormality of the fovea (HP:0000493)1.70433882
151Increased muscle lipid content (HP:0009058)1.70152002
152Cortical visual impairment (HP:0100704)1.69767053
153Gaze-evoked nystagmus (HP:0000640)1.69092256
154Emotional lability (HP:0000712)1.68932351
155Blindness (HP:0000618)1.68854835
156Absent eyebrow (HP:0002223)1.68360493
157Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67929527
158Hyperaldosteronism (HP:0000859)1.67224052
159Unsteady gait (HP:0002317)1.66536997
160Rough bone trabeculation (HP:0100670)1.64475818
161Pendular nystagmus (HP:0012043)1.63736977
162Abnormality of glycine metabolism (HP:0010895)1.63453514
163Abnormality of serine family amino acid metabolism (HP:0010894)1.63453514
164Chronic bronchitis (HP:0004469)1.60708080
165Congenital stationary night blindness (HP:0007642)1.60525530
166Male pseudohermaphroditism (HP:0000037)1.60193551
167Abnormality of the renal medulla (HP:0100957)1.60033399
168Abnormality of vitamin metabolism (HP:0100508)1.59579831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.47269832
2EPHA44.34304725
3NTRK34.06621738
4MAP3K123.84463865
5CASK3.71429374
6RIPK43.25415900
7INSRR3.17817841
8MAP2K72.80169675
9TESK22.68670683
10NME12.67787587
11BUB12.52634708
12TRIM282.43513699
13TESK12.39049011
14MAP3K42.34624476
15BMPR22.34416328
16EPHA22.16312882
17LIMK12.15726591
18ZAK2.14232985
19NME22.13346248
20MAP4K22.07200686
21CDK192.05138650
22VRK12.04402388
23BCKDK2.02468530
24PLK22.00661572
25MAP2K41.98701849
26NUAK11.95916504
27DAPK11.84629661
28ARAF1.83503672
29FRK1.80994400
30DAPK21.79473399
31SRPK11.77593373
32AKT31.76005743
33MAPK151.72061901
34MINK11.66638627
35MAP3K21.61133052
36GRK51.59038412
37MAP3K91.53804707
38PASK1.52815153
39EIF2AK11.49641461
40EIF2AK31.47928630
41NEK11.43729226
42BRAF1.42808792
43DYRK21.38100759
44TNIK1.37925929
45CSNK1G31.37280261
46KDR1.31063954
47TLK11.24930400
48CAMK2B1.24829089
49GRK11.21514354
50CSNK1G21.21395799
51CSNK1G11.20103382
52CAMK2A1.18975719
53PRKCG1.16890331
54ERBB31.13736601
55NTRK11.13147649
56TAF11.12077495
57CAMKK21.11602454
58SIK31.09550124
59PIM21.08558548
60PLK31.08547096
61CSNK1A1L1.06984315
62CDK51.06538166
63STK161.03063753
64WNK41.02797997
65TXK0.99602564
66MET0.98950147
67EPHB20.98209886
68KSR10.97845892
69OXSR10.97777833
70PTK2B0.97442435
71MST1R0.96762794
72PRKCE0.95658755
73CDC70.93759357
74PRKD30.93631516
75PNCK0.91598391
76GRK70.89979321
77LMTK20.89938415
78MAP3K10.89686850
79CAMK2D0.86128329
80MAP3K130.83653565
81WNK30.83270448
82PBK0.81189274
83FER0.80863428
84PLK10.77928546
85CCNB10.76029819
86SCYL20.75442724
87CAMKK10.74765848
88TAOK30.74495412
89MYLK0.74155947
90DYRK1A0.73820334
91TSSK60.73263584
92BCR0.72581582
93EIF2AK20.72060539
94MARK10.71739544
95KSR20.67768188
96PHKG10.67540595
97PHKG20.67540595
98ERBB40.67049725
99ABL20.67045260
100ADRBK20.66094528
101HIPK20.65087569
102BRSK20.63064747
103SGK20.62902749
104MAPKAPK30.61033654
105FGR0.61004719
106CAMK2G0.60425599
107GRK60.60391972
108ADRBK10.59901991
109SGK10.57958566
110PINK10.57188471
111PAK40.56912634
112MAPK130.56431179
113FES0.55841750
114RPS6KA50.54945885
115MST40.54719034
116PRPF4B0.53585016
117NTRK20.53130856
118SGK2230.52244051
119SGK4940.52244051
120AURKA0.51723578
121CAMK10.51497483
122PRKACA0.51122482
123PIK3CA0.50442095
124MAP2K60.49517280
125ILK0.49403705
126BMPR1B0.48384380
127RAF10.47233814
128CSNK2A20.47202686
129PAK30.47032176
130AURKB0.47009737
131MAP2K10.46370761
132PRKCA0.46330947
133PRKCI0.45090390
134CDC42BPA0.44008328
135PAK60.42534628
136STK390.42296234
137CSNK2A10.41899163
138UHMK10.41803339
139PDPK10.41045908
140FLT30.40117750
141TIE10.39927323
142RPS6KA40.39892376
143STK38L0.38322103
144CDK30.37523995
145CSNK1A10.37081413
146TNK20.37046011
147MUSK0.36738776
148STK100.36062612
149TTK0.34343122
150MKNK20.34168279
151DAPK30.33860639
152SIK20.32889684
153PRKG20.32195136
154CDK80.31705225
155BRSK10.31101858
156STK380.30998490
157PRKCQ0.30400095
158PDK10.29681645
159PRKCZ0.29356972
160ATR0.29349547
161IRAK30.29315325

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.08281371
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.86440652
3Nicotine addiction_Homo sapiens_hsa050333.39139846
4Ribosome_Homo sapiens_hsa030103.03837422
5Oxidative phosphorylation_Homo sapiens_hsa001903.00946465
6RNA polymerase_Homo sapiens_hsa030202.87649257
7Collecting duct acid secretion_Homo sapiens_hsa049662.68245158
8Amphetamine addiction_Homo sapiens_hsa050312.60992159
9Synaptic vesicle cycle_Homo sapiens_hsa047212.60572744
10Insulin secretion_Homo sapiens_hsa049112.56123843
11Sulfur metabolism_Homo sapiens_hsa009202.55600063
12Long-term potentiation_Homo sapiens_hsa047202.45173508
13Vibrio cholerae infection_Homo sapiens_hsa051102.37694677
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36515133
15Protein export_Homo sapiens_hsa030602.31872407
16Taste transduction_Homo sapiens_hsa047422.25016343
17Alzheimers disease_Homo sapiens_hsa050102.23497347
18Circadian entrainment_Homo sapiens_hsa047132.17649484
19Parkinsons disease_Homo sapiens_hsa050122.10781710
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07448866
21GABAergic synapse_Homo sapiens_hsa047271.96672968
22Morphine addiction_Homo sapiens_hsa050321.89409425
23Mismatch repair_Homo sapiens_hsa034301.86222143
24Glutamatergic synapse_Homo sapiens_hsa047241.80440104
25Dopaminergic synapse_Homo sapiens_hsa047281.79115574
26Caffeine metabolism_Homo sapiens_hsa002321.76606005
27Salivary secretion_Homo sapiens_hsa049701.71590937
28Pyrimidine metabolism_Homo sapiens_hsa002401.71534511
29DNA replication_Homo sapiens_hsa030301.65018169
30Olfactory transduction_Homo sapiens_hsa047401.64530595
31Homologous recombination_Homo sapiens_hsa034401.64076381
32Serotonergic synapse_Homo sapiens_hsa047261.62479631
33Cocaine addiction_Homo sapiens_hsa050301.60797810
34Base excision repair_Homo sapiens_hsa034101.57157181
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56089106
36Renin secretion_Homo sapiens_hsa049241.55823755
37Fatty acid elongation_Homo sapiens_hsa000621.52640182
38Huntingtons disease_Homo sapiens_hsa050161.48342051
39Gastric acid secretion_Homo sapiens_hsa049711.48316131
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44809149
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40033223
42RNA degradation_Homo sapiens_hsa030181.33211239
43Nucleotide excision repair_Homo sapiens_hsa034201.32691689
44Calcium signaling pathway_Homo sapiens_hsa040201.31068690
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30177535
46Long-term depression_Homo sapiens_hsa047301.25973973
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24013913
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23383518
49Cardiac muscle contraction_Homo sapiens_hsa042601.23355367
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22371115
51Glutathione metabolism_Homo sapiens_hsa004801.22064003
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21799794
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.21636030
54Cholinergic synapse_Homo sapiens_hsa047251.21419829
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21294920
56Chemical carcinogenesis_Homo sapiens_hsa052041.20861927
57Basal transcription factors_Homo sapiens_hsa030221.19948668
58Spliceosome_Homo sapiens_hsa030401.19835765
59Peroxisome_Homo sapiens_hsa041461.19046576
60Pancreatic secretion_Homo sapiens_hsa049721.18757865
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17880206
62Retinol metabolism_Homo sapiens_hsa008301.16716840
63Propanoate metabolism_Homo sapiens_hsa006401.16394338
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15360855
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14019730
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.12453559
67Purine metabolism_Homo sapiens_hsa002301.08964827
68Type II diabetes mellitus_Homo sapiens_hsa049301.08343362
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.07925288
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04216785
71Fanconi anemia pathway_Homo sapiens_hsa034601.01848297
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98303594
73Steroid biosynthesis_Homo sapiens_hsa001000.96908059
74Oxytocin signaling pathway_Homo sapiens_hsa049210.93304756
75RNA transport_Homo sapiens_hsa030130.92047897
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.91060718
77One carbon pool by folate_Homo sapiens_hsa006700.91004869
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89613923
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87992514
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87234892
81Non-homologous end-joining_Homo sapiens_hsa034500.86090208
82Type I diabetes mellitus_Homo sapiens_hsa049400.86008020
83GnRH signaling pathway_Homo sapiens_hsa049120.84330772
84Glucagon signaling pathway_Homo sapiens_hsa049220.84019505
85Thyroid hormone synthesis_Homo sapiens_hsa049180.83265625
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81359220
87Phototransduction_Homo sapiens_hsa047440.81261773
88cAMP signaling pathway_Homo sapiens_hsa040240.80778466
89Butanoate metabolism_Homo sapiens_hsa006500.79139635
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79047544
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77564487
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75226294
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74595372
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.72221788
95Primary immunodeficiency_Homo sapiens_hsa053400.72055744
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70330752
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68857612
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67545587
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66405873
100Mineral absorption_Homo sapiens_hsa049780.66198426
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66171275
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65766016
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65001741
104Linoleic acid metabolism_Homo sapiens_hsa005910.64887914
105Sulfur relay system_Homo sapiens_hsa041220.63684191
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62937312
107Melanogenesis_Homo sapiens_hsa049160.62886415
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61998842
109Estrogen signaling pathway_Homo sapiens_hsa049150.61942906
110Circadian rhythm_Homo sapiens_hsa047100.61058647
111Phenylalanine metabolism_Homo sapiens_hsa003600.60679006
112Gap junction_Homo sapiens_hsa045400.60349133
113Selenocompound metabolism_Homo sapiens_hsa004500.59858769
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59395375
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58446639
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58210477
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56982574
118Rheumatoid arthritis_Homo sapiens_hsa053230.54359283
119Pyruvate metabolism_Homo sapiens_hsa006200.53717695
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53510895
121Histidine metabolism_Homo sapiens_hsa003400.52169967
122Nitrogen metabolism_Homo sapiens_hsa009100.52113680
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.52070153
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50355108
125Arachidonic acid metabolism_Homo sapiens_hsa005900.50344240
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49875334
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49560728
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49079577
129Regulation of autophagy_Homo sapiens_hsa041400.48078174
130Starch and sucrose metabolism_Homo sapiens_hsa005000.47620146
131Tryptophan metabolism_Homo sapiens_hsa003800.47475570
132Vitamin digestion and absorption_Homo sapiens_hsa049770.47284271
133Vitamin B6 metabolism_Homo sapiens_hsa007500.47257936
134Carbon metabolism_Homo sapiens_hsa012000.47044707
135Biosynthesis of amino acids_Homo sapiens_hsa012300.45927176
136African trypanosomiasis_Homo sapiens_hsa051430.45482433
137Bile secretion_Homo sapiens_hsa049760.45106421
138Galactose metabolism_Homo sapiens_hsa000520.42371273
139Fructose and mannose metabolism_Homo sapiens_hsa000510.41310009
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40268510
141Fatty acid degradation_Homo sapiens_hsa000710.39460392
142Tyrosine metabolism_Homo sapiens_hsa003500.37422325
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34507722
144beta-Alanine metabolism_Homo sapiens_hsa004100.34062650
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31832751
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31764040
147Folate biosynthesis_Homo sapiens_hsa007900.30792488
148Prion diseases_Homo sapiens_hsa050200.30785154
149p53 signaling pathway_Homo sapiens_hsa041150.29272526
150Metabolic pathways_Homo sapiens_hsa011000.28402762
151Fat digestion and absorption_Homo sapiens_hsa049750.28372002
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28085036
153N-Glycan biosynthesis_Homo sapiens_hsa005100.21563873
154Inositol phosphate metabolism_Homo sapiens_hsa005620.21148008
155Alcoholism_Homo sapiens_hsa050340.19933680
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19653915
157Glioma_Homo sapiens_hsa052140.19573096
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19188016
159ErbB signaling pathway_Homo sapiens_hsa040120.18840105
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17948657

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