OCLM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is induced by cyclic mechanical stretching in trabecular cells of the eye and it is also expressed in retina. This protein may play a role in trabecular meshwork function and the development of glaucoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)6.07020977
2prenylation (GO:0097354)5.41460368
3protein prenylation (GO:0018342)5.41460368
4response to pheromone (GO:0019236)5.29588057
5lactate metabolic process (GO:0006089)5.15153149
6regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.31114404
7histone H2A acetylation (GO:0043968)3.87676801
8centriole replication (GO:0007099)3.85181034
9negative regulation of execution phase of apoptosis (GO:1900118)3.82190188
10photoreceptor cell maintenance (GO:0045494)3.54987227
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49686494
12regulation of mitotic spindle checkpoint (GO:1903504)3.49686494
13cytochrome complex assembly (GO:0017004)3.41503810
14mitotic sister chromatid cohesion (GO:0007064)3.38754786
15negative regulation of neurological system process (GO:0031645)3.38530562
16regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.36903823
17respiratory chain complex IV assembly (GO:0008535)3.32091957
18positive regulation of glycolytic process (GO:0045821)3.28701322
19intraciliary transport (GO:0042073)3.19986209
20water-soluble vitamin biosynthetic process (GO:0042364)3.13942992
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.10037599
22fucose catabolic process (GO:0019317)3.09857523
23L-fucose metabolic process (GO:0042354)3.09857523
24L-fucose catabolic process (GO:0042355)3.09857523
25replication fork processing (GO:0031297)3.09771052
26axoneme assembly (GO:0035082)3.09594841
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09398662
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.09398662
29somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06760662
30somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06760662
31isotype switching (GO:0045190)3.06760662
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04566407
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04566407
34positive regulation of mitotic sister chromatid separation (GO:1901970)3.04566407
35double-strand break repair via nonhomologous end joining (GO:0006303)2.98572855
36non-recombinational repair (GO:0000726)2.98572855
37signal peptide processing (GO:0006465)2.98142178
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98093474
39negative regulation of translation, ncRNA-mediated (GO:0040033)2.98093474
40regulation of translation, ncRNA-mediated (GO:0045974)2.98093474
41positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.97975170
42regulation of glucokinase activity (GO:0033131)2.97422754
43regulation of hexokinase activity (GO:1903299)2.97422754
44C4-dicarboxylate transport (GO:0015740)2.92140830
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91877546
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90877769
47regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.83767430
48DNA double-strand break processing (GO:0000729)2.83560420
49regulation of cilium movement (GO:0003352)2.82643406
50estrogen biosynthetic process (GO:0006703)2.82364896
51glycosphingolipid biosynthetic process (GO:0006688)2.80699815
52auditory receptor cell differentiation (GO:0042491)2.80416716
53heme transport (GO:0015886)2.80094062
54negative regulation of DNA-dependent DNA replication (GO:2000104)2.78062483
55platelet dense granule organization (GO:0060155)2.76325031
56regulation of telomere maintenance (GO:0032204)2.74940773
57mRNA modification (GO:0016556)2.74642881
58nonmotile primary cilium assembly (GO:0035058)2.73667478
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72515831
60positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.72447567
61cilium morphogenesis (GO:0060271)2.70319275
62monoubiquitinated protein deubiquitination (GO:0035520)2.69031406
63negative regulation of JUN kinase activity (GO:0043508)2.68029624
64basic amino acid transport (GO:0015802)2.67156717
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65442569
66acrosome reaction (GO:0007340)2.65309232
67inositol phosphate catabolic process (GO:0071545)2.61781394
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59105485
69protein K63-linked deubiquitination (GO:0070536)2.57565864
70regulation of acyl-CoA biosynthetic process (GO:0050812)2.56845227
71cilium organization (GO:0044782)2.56807091
72regulation of meiosis I (GO:0060631)2.52664747
73nodal signaling pathway (GO:0038092)2.52168931
74cilium assembly (GO:0042384)2.50295250
75fatty acid elongation (GO:0030497)2.48885213
76proteasome assembly (GO:0043248)2.47699511
77negative regulation of thymocyte apoptotic process (GO:0070244)2.46558503
78epithelial cilium movement (GO:0003351)2.44352004
79dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.43939821
80brain morphogenesis (GO:0048854)2.43600016
81resolution of meiotic recombination intermediates (GO:0000712)2.41476874
82negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.40786271
83retinal cone cell development (GO:0046549)2.40768064
84nucleotide transmembrane transport (GO:1901679)2.40587710
85regulation of protein glycosylation (GO:0060049)2.40541241
86positive regulation of mRNA processing (GO:0050685)2.38253372
87double-strand break repair via homologous recombination (GO:0000724)2.37470953
88recombinational repair (GO:0000725)2.37302375
89zinc ion transport (GO:0006829)2.36626624
90regulation of centriole replication (GO:0046599)2.35512240
91branched-chain amino acid catabolic process (GO:0009083)2.35222582
92prostate gland growth (GO:0060736)2.34214400
93synapsis (GO:0007129)2.33619988
94protein polyglutamylation (GO:0018095)2.33508484
95lipid particle organization (GO:0034389)2.31766263
96positive regulation of hormone biosynthetic process (GO:0046886)2.31525628
97positive regulation of mRNA metabolic process (GO:1903313)2.30953896
98cholesterol biosynthetic process (GO:0006695)2.30826243
99estrogen metabolic process (GO:0008210)2.29967558
100sterol biosynthetic process (GO:0016126)2.29662428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.29476205
2* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.12023478
3IGF1R_20145208_ChIP-Seq_DFB_Human2.97955696
4ZNF274_21170338_ChIP-Seq_K562_Hela2.89841647
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.58596745
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.53124668
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52258335
8GBX2_23144817_ChIP-Seq_PC3_Human2.49302691
9TAF15_26573619_Chip-Seq_HEK293_Human2.42736508
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34519608
11VDR_22108803_ChIP-Seq_LS180_Human2.34092851
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29257162
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27667476
14EWS_26573619_Chip-Seq_HEK293_Human2.20905671
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10755512
16FUS_26573619_Chip-Seq_HEK293_Human2.10745227
17P300_19829295_ChIP-Seq_ESCs_Human2.02864838
18ELK1_19687146_ChIP-ChIP_HELA_Human1.97165678
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95604980
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94699785
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86282647
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84096200
23EZH2_27294783_Chip-Seq_NPCs_Mouse1.78333980
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.76234774
25BCAT_22108803_ChIP-Seq_LS180_Human1.74911823
26ER_23166858_ChIP-Seq_MCF-7_Human1.73343053
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.73030328
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71296877
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67297495
30SMAD4_21799915_ChIP-Seq_A2780_Human1.66004475
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65308011
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64299055
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63387123
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62942047
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.60383116
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.59984412
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59647249
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55759405
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.53834431
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51567264
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47461211
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46810540
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45919244
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.45145825
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44412241
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43300003
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42974992
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42260365
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.39425636
50STAT3_23295773_ChIP-Seq_U87_Human1.36800535
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35312392
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35184693
53P53_22387025_ChIP-Seq_ESCs_Mouse1.34869602
54* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34690617
55* CBP_20019798_ChIP-Seq_JUKART_Human1.34690617
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33413089
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32047520
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.31402379
59TCF4_23295773_ChIP-Seq_U87_Human1.30144863
60P300_18555785_Chip-Seq_ESCs_Mouse1.29849532
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.29172520
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28562156
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28344834
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26679466
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26481139
66SOX2_19829295_ChIP-Seq_ESCs_Human1.26360786
67NANOG_19829295_ChIP-Seq_ESCs_Human1.26360786
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25327063
69OCT4_18555785_Chip-Seq_ESCs_Mouse1.25192571
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.24635312
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24505956
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.24050102
73VDR_23849224_ChIP-Seq_CD4+_Human1.24045491
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.23935274
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23421767
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23369985
77CDX2_22108803_ChIP-Seq_LS180_Human1.22948703
78HTT_18923047_ChIP-ChIP_STHdh_Human1.22780239
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20709893
80* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20195753
81TCF4_22108803_ChIP-Seq_LS180_Human1.19074391
82AR_25329375_ChIP-Seq_VCAP_Human1.18720048
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17746752
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15319455
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15113686
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12885616
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11868690
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10871652
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.10220272
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06848243
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06496879
92ZFX_18555785_Chip-Seq_ESCs_Mouse1.05887064
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.03919090
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.03843088
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03203395
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01899091
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.01855127
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99731986
99SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99533800
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99504386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.04877155
2MP0002254_reproductive_system_inflammat2.89154546
3MP0002876_abnormal_thyroid_physiology2.70534345
4MP0003787_abnormal_imprinting2.69647765
5MP0008877_abnormal_DNA_methylation2.59608166
6MP0010234_abnormal_vibrissa_follicle2.48062546
7MP0008057_abnormal_DNA_replication2.43749895
8MP0001984_abnormal_olfaction2.41500395
9MP0002009_preneoplasia2.30603981
10MP0003950_abnormal_plasma_membrane2.27933251
11MP0003195_calcinosis2.25947699
12MP0009780_abnormal_chondrocyte_physiolo2.25287709
13MP0005551_abnormal_eye_electrophysiolog2.15181144
14MP0000516_abnormal_urinary_system2.11647072
15MP0005367_renal/urinary_system_phenotyp2.11647072
16MP0003786_premature_aging2.09239400
17MP0005084_abnormal_gallbladder_morpholo2.06255285
18MP0003718_maternal_effect2.02459293
19MP0008058_abnormal_DNA_repair2.01419568
20MP0005253_abnormal_eye_physiology2.00916706
21MP0002102_abnormal_ear_morphology1.96791464
22MP0002938_white_spotting1.95322746
23MP0006072_abnormal_retinal_apoptosis1.83831150
24MP0002837_dystrophic_cardiac_calcinosis1.80818959
25MP0000427_abnormal_hair_cycle1.80745184
26MP0003880_abnormal_central_pattern1.78527876
27MP0008007_abnormal_cellular_replicative1.72687549
28MP0005645_abnormal_hypothalamus_physiol1.67586293
29MP0001986_abnormal_taste_sensitivity1.66421337
30MP0001764_abnormal_homeostasis1.60545323
31MP0010386_abnormal_urinary_bladder1.60054572
32MP0005174_abnormal_tail_pigmentation1.49858326
33MP0000569_abnormal_digit_pigmentation1.49116305
34MP0010678_abnormal_skin_adnexa1.49069168
35MP0002166_altered_tumor_susceptibility1.48063795
36MP0008995_early_reproductive_senescence1.46426830
37MP0009046_muscle_twitch1.44927016
38MP0001501_abnormal_sleep_pattern1.39554392
39MP0003122_maternal_imprinting1.37692199
40MP0005646_abnormal_pituitary_gland1.37466398
41MP0002928_abnormal_bile_duct1.37317209
42MP0008775_abnormal_heart_ventricle1.36183300
43MP0005395_other_phenotype1.35708837
44MP0001873_stomach_inflammation1.35079475
45MP0004215_abnormal_myocardial_fiber1.34643557
46MP0002234_abnormal_pharynx_morphology1.31912403
47MP0000631_abnormal_neuroendocrine_gland1.30603451
48MP0002638_abnormal_pupillary_reflex1.28463953
49MP0003252_abnormal_bile_duct1.27939905
50MP0004147_increased_porphyrin_level1.23059700
51MP0001944_abnormal_pancreas_morphology1.20689635
52MP0005379_endocrine/exocrine_gland_phen1.19982493
53MP0002139_abnormal_hepatobiliary_system1.19183786
54MP0003121_genomic_imprinting1.18807653
55MP0004043_abnormal_pH_regulation1.17738829
56MP0006054_spinal_hemorrhage1.16895990
57MP0002006_tumorigenesis1.15843057
58MP0003656_abnormal_erythrocyte_physiolo1.15460162
59MP0010094_abnormal_chromosome_stability1.13108599
60MP0008789_abnormal_olfactory_epithelium1.12512819
61MP0000383_abnormal_hair_follicle1.10901382
62MP0002168_other_aberrant_phenotype1.07897348
63MP0000538_abnormal_urinary_bladder1.06935506
64MP0008872_abnormal_physiological_respon1.05966519
65MP0005365_abnormal_bile_salt1.02414373
66MP0010352_gastrointestinal_tract_polyps1.02066785
67MP0006036_abnormal_mitochondrial_physio1.00492590
68MP0004084_abnormal_cardiac_muscle1.00177354
69MP0010307_abnormal_tumor_latency0.96035579
70MP0003186_abnormal_redox_activity0.94629072
71MP0002693_abnormal_pancreas_physiology0.91947387
72MP0000613_abnormal_salivary_gland0.91431983
73MP0002751_abnormal_autonomic_nervous0.91042359
74MP0002095_abnormal_skin_pigmentation0.88118800
75MP0005332_abnormal_amino_acid0.87634564
76MP0002396_abnormal_hematopoietic_system0.87223795
77MP0001929_abnormal_gametogenesis0.86068565
78MP0001324_abnormal_eye_pigmentation0.84211989
79MP0002282_abnormal_trachea_morphology0.83017173
80MP0002163_abnormal_gland_morphology0.81713896
81MP0003868_abnormal_feces_composition0.81170187
82MP0005220_abnormal_exocrine_pancreas0.79247576
83MP0005085_abnormal_gallbladder_physiolo0.77732442
84MP0004924_abnormal_behavior0.76209416
85MP0005386_behavior/neurological_phenoty0.76209416
86MP0001529_abnormal_vocalization0.74578399
87MP0005408_hypopigmentation0.74153214
88MP0001666_abnormal_nutrient_absorption0.72439156
89MP0002233_abnormal_nose_morphology0.70559890
90MP0010329_abnormal_lipoprotein_level0.70266565
91MP0009697_abnormal_copulation0.69493782
92MP0003937_abnormal_limbs/digits/tail_de0.68449914
93MP0005623_abnormal_meninges_morphology0.68341239
94MP0003137_abnormal_impulse_conducting0.67356779
95MP0003111_abnormal_nucleus_morphology0.67143653
96MP0001119_abnormal_female_reproductive0.66400344
97MP0001756_abnormal_urination0.65683351
98MP0002229_neurodegeneration0.65437402
99MP0000653_abnormal_sex_gland0.64195209
100MP0002184_abnormal_innervation0.61649190

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.62556268
2Abnormality of midbrain morphology (HP:0002418)3.43194101
3Molar tooth sign on MRI (HP:0002419)3.43194101
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.27760140
5Pancreatic fibrosis (HP:0100732)3.26333509
6Volvulus (HP:0002580)3.24392071
7Gaze-evoked nystagmus (HP:0000640)3.11821985
8Medial flaring of the eyebrow (HP:0010747)3.08992282
9Abnormality of the renal cortex (HP:0011035)3.03773562
10Ependymoma (HP:0002888)2.83827435
11Abnormal rod and cone electroretinograms (HP:0008323)2.83159260
12Bile duct proliferation (HP:0001408)2.82439792
13Abnormal biliary tract physiology (HP:0012439)2.82439792
14True hermaphroditism (HP:0010459)2.80866566
15Tubulointerstitial nephritis (HP:0001970)2.76315291
16Renal cortical cysts (HP:0000803)2.70678779
17Nephronophthisis (HP:0000090)2.69548403
18Attenuation of retinal blood vessels (HP:0007843)2.59160354
19Hypothermia (HP:0002045)2.54670526
20Abnormality of the renal medulla (HP:0100957)2.46414939
21Congenital primary aphakia (HP:0007707)2.45206553
22Thyroiditis (HP:0100646)2.44799965
23Constricted visual fields (HP:0001133)2.43299890
24Aqueductal stenosis (HP:0002410)2.42173121
25Intestinal atresia (HP:0011100)2.41114882
26Dyschromatopsia (HP:0007641)2.38640394
27Astrocytoma (HP:0009592)2.36384426
28Abnormality of the astrocytes (HP:0100707)2.36384426
29Gait imbalance (HP:0002141)2.35239409
30Pancreatic islet-cell hyperplasia (HP:0004510)2.32045976
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.28067495
32Tubular atrophy (HP:0000092)2.27608696
33Genital tract atresia (HP:0001827)2.24723052
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23807562
35Glioma (HP:0009733)2.23749579
36Nephrogenic diabetes insipidus (HP:0009806)2.20994151
37Hyperinsulinemic hypoglycemia (HP:0000825)2.20550626
38Furrowed tongue (HP:0000221)2.17886368
39Abolished electroretinogram (ERG) (HP:0000550)2.11042942
40Progressive inability to walk (HP:0002505)2.10458135
41Absent speech (HP:0001344)2.10179207
42Hypoglycemic coma (HP:0001325)2.10164230
43Vaginal atresia (HP:0000148)2.09695109
44Colon cancer (HP:0003003)2.09039637
45Oculomotor apraxia (HP:0000657)2.09014909
46Large for gestational age (HP:0001520)2.08463722
47Occipital encephalocele (HP:0002085)2.06120597
48Hyperglycinemia (HP:0002154)2.04493104
49Postaxial foot polydactyly (HP:0001830)2.02498235
50Neuroendocrine neoplasm (HP:0100634)2.01204578
51Hyperventilation (HP:0002883)2.01167352
52Hamartoma of the eye (HP:0010568)1.98991139
53Cystic liver disease (HP:0006706)1.97601615
54Abnormality of the labia minora (HP:0012880)1.97322397
55Neoplasm of the adrenal cortex (HP:0100641)1.97220122
56Chronic hepatic failure (HP:0100626)1.93882950
57Proximal tubulopathy (HP:0000114)1.92345807
58Neonatal respiratory distress (HP:0002643)1.91534014
59Hypoglycemic seizures (HP:0002173)1.91196405
60Hypoproteinemia (HP:0003075)1.85361262
61Bifid tongue (HP:0010297)1.83323205
62Neoplasm of the adrenal gland (HP:0100631)1.82261687
63Chronic mucocutaneous candidiasis (HP:0002728)1.81998589
64Recurrent cutaneous fungal infections (HP:0011370)1.81998589
65Progressive macrocephaly (HP:0004481)1.81699713
66Atonic seizures (HP:0010819)1.81468784
67Pendular nystagmus (HP:0012043)1.81381077
68Congenital hepatic fibrosis (HP:0002612)1.81285422
69Renal hypoplasia (HP:0000089)1.79000891
70Sloping forehead (HP:0000340)1.78980348
71Chorioretinal coloboma (HP:0000567)1.77816174
72Abnormality of the pancreatic islet cells (HP:0006476)1.77540990
73Abnormality of endocrine pancreas physiology (HP:0012093)1.77540990
74Hypoplastic pelvis (HP:0008839)1.77262244
75Inability to walk (HP:0002540)1.76496941
76Postaxial hand polydactyly (HP:0001162)1.75064238
77Widely spaced teeth (HP:0000687)1.74171995
78Rhabdomyosarcoma (HP:0002859)1.73532273
79Poor coordination (HP:0002370)1.73505133
80Macular degeneration (HP:0000608)1.72820395
81Abnormality of macular pigmentation (HP:0008002)1.72315489
82Febrile seizures (HP:0002373)1.72249032
83Aplasia/hypoplasia of the uterus (HP:0008684)1.71860605
84Congenital stationary night blindness (HP:0007642)1.70706155
85Spastic paraparesis (HP:0002313)1.70435940
86Conjunctival hamartoma (HP:0100780)1.70373538
87Tubulointerstitial abnormality (HP:0001969)1.69911344
88Congenital sensorineural hearing impairment (HP:0008527)1.69654276
89Hypoplastic labia majora (HP:0000059)1.69377517
90Breast carcinoma (HP:0003002)1.67568133
91Abnormality of methionine metabolism (HP:0010901)1.66924654
92Abnormality of vitamin B metabolism (HP:0004340)1.66637510
93Sclerocornea (HP:0000647)1.65252135
94Metaphyseal dysplasia (HP:0100255)1.65077985
95Type I transferrin isoform profile (HP:0003642)1.62993951
96Abnormal biliary tract morphology (HP:0012440)1.62699870
97Pigmentary retinal degeneration (HP:0001146)1.62196504
98Narrow forehead (HP:0000341)1.61516314
99Abnormal albumin level (HP:0012116)1.61373062
100Hypoalbuminemia (HP:0003073)1.61373062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.70234324
2WNK34.84396630
3MST43.40474624
4BRSK23.14765092
5EIF2AK32.85919645
6TRIM282.33220860
7NUAK12.28650706
8FGFR22.22134337
9PDK22.10101484
10EIF2AK12.05743299
11TXK1.87077617
12PLK31.85548231
13MKNK21.72867350
14MAP4K21.64372952
15BCR1.61288079
16STK241.56029678
17TNIK1.53963443
18ERBB31.49936372
19GRK11.47782821
20AKT31.41351208
21ZAK1.41119601
22PAK31.34025525
23PLK41.30521480
24STK31.30243740
25CAMKK21.29118786
26EPHA41.26002350
27NEK11.19342473
28MKNK11.18776469
29TAOK31.17162126
30ADRBK21.15543138
31BRD41.15103435
32TSSK61.14046858
33NLK1.13053686
34BRSK11.11385956
35CASK1.10376327
36TRPM71.06740143
37INSRR1.06452051
38ACVR1B1.04200517
39STK391.03618816
40OXSR11.03267551
41MAP3K120.99993505
42YES10.99710664
43SIK30.99165127
44CSNK1G10.98547489
45WEE10.97931008
46MAPK130.96494933
47BMPR1B0.95920306
48ERBB40.91071188
49PLK20.88117515
50EIF2AK20.86048376
51MAP3K40.84411752
52BUB10.84293314
53STK38L0.83409931
54PINK10.83299068
55MUSK0.81103089
56FER0.79802009
57UHMK10.79138436
58PBK0.77751442
59PRKCE0.72470448
60SGK20.64680597
61CCNB10.64257147
62PLK10.64057591
63SRPK10.62085472
64ATM0.61906935
65CSNK1A1L0.59727167
66PTK2B0.58599780
67TNK20.55365326
68CDK30.55300882
69PNCK0.53434467
70CAMK1G0.52862200
71MAP3K140.49929093
72CSNK1G30.48272243
73CSNK1G20.47553428
74PRKCQ0.47033248
75SGK30.44581156
76PRKCG0.42557916
77DAPK20.42191382
78TGFBR10.39171342
79PIK3CA0.35777913
80STK380.34824466
81CSNK1D0.34717771
82CSNK1A10.34644129
83CDK90.34322658
84ATR0.32991590
85TTK0.31562650
86CLK10.31428406
87CAMK1D0.30560580
88PRKCZ0.30091251
89PRKAA10.28154401
90PRKAA20.27706650
91ILK0.27519501
92ABL10.27519270
93FGFR30.26943785
94LATS10.26921585
95ROCK10.25600550
96CHEK10.25507944
97EGFR0.25395876
98STK100.24983587
99PRKDC0.24922645
100MAP3K20.24685317

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.72462910
2Protein export_Homo sapiens_hsa030603.19072215
3Proteasome_Homo sapiens_hsa030502.74191109
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60299078
5Propanoate metabolism_Homo sapiens_hsa006402.52195394
6Circadian rhythm_Homo sapiens_hsa047102.50595817
7Fatty acid elongation_Homo sapiens_hsa000622.38426272
8One carbon pool by folate_Homo sapiens_hsa006702.13516162
9Basal transcription factors_Homo sapiens_hsa030222.09901907
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.09607820
11Steroid biosynthesis_Homo sapiens_hsa001002.07168173
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05265486
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03785276
14Vitamin B6 metabolism_Homo sapiens_hsa007502.03410595
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02625448
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.01606367
17Butanoate metabolism_Homo sapiens_hsa006501.99970347
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98419818
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93171845
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93006786
21RNA degradation_Homo sapiens_hsa030181.91224899
22RNA polymerase_Homo sapiens_hsa030201.83395257
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82992289
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72884611
25Phototransduction_Homo sapiens_hsa047441.71422685
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68144953
27Fatty acid metabolism_Homo sapiens_hsa012121.66469073
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65907896
29Selenocompound metabolism_Homo sapiens_hsa004501.61601646
30Regulation of autophagy_Homo sapiens_hsa041401.56646705
31Nitrogen metabolism_Homo sapiens_hsa009101.46943334
32Fanconi anemia pathway_Homo sapiens_hsa034601.36562942
33Ether lipid metabolism_Homo sapiens_hsa005651.34113192
34Linoleic acid metabolism_Homo sapiens_hsa005911.24731573
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21278447
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14945953
37Mismatch repair_Homo sapiens_hsa034301.13340885
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13196339
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11427142
40Homologous recombination_Homo sapiens_hsa034401.06117900
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.05295808
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05209224
43RNA transport_Homo sapiens_hsa030131.00493530
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00208821
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99276615
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93990971
47Caffeine metabolism_Homo sapiens_hsa002320.88979155
48Peroxisome_Homo sapiens_hsa041460.85062736
49Taste transduction_Homo sapiens_hsa047420.84274134
50Oocyte meiosis_Homo sapiens_hsa041140.83820188
51Sphingolipid metabolism_Homo sapiens_hsa006000.82492294
52p53 signaling pathway_Homo sapiens_hsa041150.77726389
53Tryptophan metabolism_Homo sapiens_hsa003800.76352443
54Insulin secretion_Homo sapiens_hsa049110.72146797
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71014615
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.68380822
57Glutathione metabolism_Homo sapiens_hsa004800.66561084
58Collecting duct acid secretion_Homo sapiens_hsa049660.64109693
59Arginine biosynthesis_Homo sapiens_hsa002200.60982172
60Pancreatic secretion_Homo sapiens_hsa049720.60098914
61Lysine degradation_Homo sapiens_hsa003100.57064783
62Metabolic pathways_Homo sapiens_hsa011000.56899304
63Fat digestion and absorption_Homo sapiens_hsa049750.55972097
64Type I diabetes mellitus_Homo sapiens_hsa049400.55111301
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54694008
66Hedgehog signaling pathway_Homo sapiens_hsa043400.54307451
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.53621528
68Oxidative phosphorylation_Homo sapiens_hsa001900.51500598
69Glucagon signaling pathway_Homo sapiens_hsa049220.51319805
70Nucleotide excision repair_Homo sapiens_hsa034200.51038430
71Purine metabolism_Homo sapiens_hsa002300.50854169
72Fatty acid degradation_Homo sapiens_hsa000710.50698270
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50135006
74ABC transporters_Homo sapiens_hsa020100.49523595
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49424605
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49318057
77Sulfur metabolism_Homo sapiens_hsa009200.49102081
78TGF-beta signaling pathway_Homo sapiens_hsa043500.47550981
79Pyrimidine metabolism_Homo sapiens_hsa002400.46527419
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43591064
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43339010
82Nicotine addiction_Homo sapiens_hsa050330.40930173
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40087309
84GABAergic synapse_Homo sapiens_hsa047270.38556745
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37440647
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36412821
87Retinol metabolism_Homo sapiens_hsa008300.35407003
88beta-Alanine metabolism_Homo sapiens_hsa004100.34329290
89mTOR signaling pathway_Homo sapiens_hsa041500.33680302
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31953578
91Wnt signaling pathway_Homo sapiens_hsa043100.30840264
92Starch and sucrose metabolism_Homo sapiens_hsa005000.29735410
93Arachidonic acid metabolism_Homo sapiens_hsa005900.29689558
94Pyruvate metabolism_Homo sapiens_hsa006200.29275256
95Carbon metabolism_Homo sapiens_hsa012000.27691590
96Tight junction_Homo sapiens_hsa045300.26331386
97Serotonergic synapse_Homo sapiens_hsa047260.25354425
98Vitamin digestion and absorption_Homo sapiens_hsa049770.24059442
99Olfactory transduction_Homo sapiens_hsa047400.22651568
100mRNA surveillance pathway_Homo sapiens_hsa030150.21873868

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