OCLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)5.00536503
2fat-soluble vitamin biosynthetic process (GO:0042362)4.90829817
3vitamin transmembrane transport (GO:0035461)4.78549806
4intestinal absorption (GO:0050892)4.71460070
5bundle of His cell to Purkinje myocyte communication (GO:0086069)4.64457207
6keratinocyte development (GO:0003334)4.35346991
7cysteine metabolic process (GO:0006534)4.24446541
8sulfur amino acid catabolic process (GO:0000098)4.07598813
9sodium-independent organic anion transport (GO:0043252)4.06411243
10urate metabolic process (GO:0046415)4.05743507
11homocysteine metabolic process (GO:0050667)4.01993849
12regulation of bile acid biosynthetic process (GO:0070857)4.01561509
13L-phenylalanine metabolic process (GO:0006558)4.01391577
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.01391577
15L-phenylalanine catabolic process (GO:0006559)4.00263973
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.00263973
17water-soluble vitamin biosynthetic process (GO:0042364)3.87032551
18regulation of triglyceride catabolic process (GO:0010896)3.86406738
19desmosome organization (GO:0002934)3.85958914
20drug catabolic process (GO:0042737)3.85016994
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.84921011
22respiratory chain complex IV assembly (GO:0008535)3.81745681
23pyrimidine-containing compound transmembrane transport (GO:0072531)3.79708044
24regulation of cholesterol homeostasis (GO:2000188)3.78139320
25bile acid and bile salt transport (GO:0015721)3.75443766
26amino-acid betaine metabolic process (GO:0006577)3.73206988
27reverse cholesterol transport (GO:0043691)3.72620731
28intestinal epithelial cell development (GO:0060576)3.72318580
29urea cycle (GO:0000050)3.71342552
30urea metabolic process (GO:0019627)3.71342552
31modified amino acid transport (GO:0072337)3.71131704
32aromatic amino acid family catabolic process (GO:0009074)3.69186045
33response to nitrosative stress (GO:0051409)3.67290283
34high-density lipoprotein particle remodeling (GO:0034375)3.66240706
35lymph vessel development (GO:0001945)3.65631533
36positive regulation of glycoprotein biosynthetic process (GO:0010560)3.62886757
37lactate metabolic process (GO:0006089)3.55150204
38phospholipid efflux (GO:0033700)3.50037595
39calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.49898180
40transcytosis (GO:0045056)3.49220486
41surfactant homeostasis (GO:0043129)3.48094998
42indole-containing compound catabolic process (GO:0042436)3.46248728
43indolalkylamine catabolic process (GO:0046218)3.46248728
44tryptophan catabolic process (GO:0006569)3.46248728
45tryptophan metabolic process (GO:0006568)3.43963013
46drug transmembrane transport (GO:0006855)3.41543578
47regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.40386847
48vitamin transport (GO:0051180)3.39214584
49nitrogen cycle metabolic process (GO:0071941)3.38715364
50endothelium development (GO:0003158)3.35442149
51peptidyl-glutamic acid carboxylation (GO:0017187)3.31453174
52protein carboxylation (GO:0018214)3.31453174
53bile acid biosynthetic process (GO:0006699)3.28744070
54cytochrome complex assembly (GO:0017004)3.27078341
55serine family amino acid catabolic process (GO:0009071)3.24692576
56ethanol metabolic process (GO:0006067)3.22120057
57detection of bacterium (GO:0016045)3.21662161
58regulation of cholesterol esterification (GO:0010872)3.21106405
59flavonoid metabolic process (GO:0009812)3.20565287
60regulation of protein activation cascade (GO:2000257)3.20407062
61cellular ketone body metabolic process (GO:0046950)3.18624090
62bile acid metabolic process (GO:0008206)3.18230974
63negative regulation of cholesterol transport (GO:0032375)3.17992682
64negative regulation of sterol transport (GO:0032372)3.17992682
65triglyceride homeostasis (GO:0070328)3.17512597
66acylglycerol homeostasis (GO:0055090)3.17512597
67lipoprotein metabolic process (GO:0042157)3.12986951
68chemical homeostasis within a tissue (GO:0048875)3.12250123
69regulation of water loss via skin (GO:0033561)3.11947730
70UDP-N-acetylglucosamine metabolic process (GO:0006047)3.11140252
71negative regulation of lipase activity (GO:0060192)3.09930620
72sphingoid metabolic process (GO:0046519)3.09811586
73transepithelial transport (GO:0070633)3.08282240
74primary alcohol catabolic process (GO:0034310)3.08235245
75heme transport (GO:0015886)3.08190095
76regulation of hexokinase activity (GO:1903299)3.07780229
77regulation of glucokinase activity (GO:0033131)3.07780229
78positive regulation of glycoprotein metabolic process (GO:1903020)3.05320637
79cholesterol efflux (GO:0033344)3.05116213
80hormone catabolic process (GO:0042447)3.04635746
81carnitine metabolic process (GO:0009437)3.04622992
82regulation of complement activation (GO:0030449)3.04423177
83plasma lipoprotein particle remodeling (GO:0034369)3.03366520
84protein-lipid complex remodeling (GO:0034368)3.03366520
85macromolecular complex remodeling (GO:0034367)3.03366520
86nodal signaling pathway (GO:0038092)3.03099677
87lung vasculature development (GO:0060426)3.01623651
88branched-chain amino acid catabolic process (GO:0009083)2.99446207
89cellular glucuronidation (GO:0052695)2.98382037
90kynurenine metabolic process (GO:0070189)2.97745260
91DNA double-strand break processing (GO:0000729)2.97190970
92cholesterol homeostasis (GO:0042632)2.95750049
93regulation of fibrinolysis (GO:0051917)2.95106937
94diol metabolic process (GO:0034311)2.94913879
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94443221
96establishment of skin barrier (GO:0061436)2.93573398
97negative regulation of keratinocyte proliferation (GO:0010839)2.92567601
98sterol homeostasis (GO:0055092)2.92259812
99sphingosine metabolic process (GO:0006670)2.92187915
100glyoxylate metabolic process (GO:0046487)2.87553955
101drug transport (GO:0015893)2.86992563
102plasma lipoprotein particle assembly (GO:0034377)2.86181801
103response to pheromone (GO:0019236)2.85473838
104aromatic amino acid family metabolic process (GO:0009072)2.83934674
105kidney morphogenesis (GO:0060993)2.82627860
106negative regulation of fibrinolysis (GO:0051918)2.80815173
107somite rostral/caudal axis specification (GO:0032525)2.80789147
108phospholipid homeostasis (GO:0055091)2.80466620
109very-low-density lipoprotein particle assembly (GO:0034379)2.80092897
110complement activation, alternative pathway (GO:0006957)2.78593043
111glutathione derivative metabolic process (GO:1901685)2.78024916
112glutathione derivative biosynthetic process (GO:1901687)2.78024916
113glucuronate metabolic process (GO:0019585)2.78001364
114uronic acid metabolic process (GO:0006063)2.78001364
115ketone body metabolic process (GO:1902224)2.76966665
116L-fucose catabolic process (GO:0042355)2.74864745
117fucose catabolic process (GO:0019317)2.74864745
118L-fucose metabolic process (GO:0042354)2.74864745
119vitamin biosynthetic process (GO:0009110)2.74376287
120detection of other organism (GO:0098543)2.74331631
121sulfur compound transport (GO:0072348)2.74102960
122regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.70652820
123zinc ion transport (GO:0006829)2.69972186
124negative regulation of JUN kinase activity (GO:0043508)2.69787668
125regulation of hippo signaling (GO:0035330)2.69328660
126negative regulation of translation, ncRNA-mediated (GO:0040033)2.67470877
127regulation of translation, ncRNA-mediated (GO:0045974)2.67470877
128negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67470877
129platelet dense granule organization (GO:0060155)2.66463930
130regulation of sulfur metabolic process (GO:0042762)2.65331874
131positive regulation of protein autophosphorylation (GO:0031954)2.60104025
132dorsal/ventral axis specification (GO:0009950)2.56622263
133negative regulation of DNA-dependent DNA replication (GO:2000104)2.54840605
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.54108644
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.53333830
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.53333830
137signal transduction involved in regulation of gene expression (GO:0023019)2.51606873
138auditory receptor cell differentiation (GO:0042491)2.50484029
139negative regulation of execution phase of apoptosis (GO:1900118)2.50189256
140regulation of keratinocyte proliferation (GO:0010837)2.49732597
141magnesium ion transport (GO:0015693)2.46685756
142protein prenylation (GO:0018342)2.44555202
143prenylation (GO:0097354)2.44555202
144nucleotide transmembrane transport (GO:1901679)2.44378176
145thyroid hormone metabolic process (GO:0042403)2.42275281
146replication fork processing (GO:0031297)2.39832308
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39296573
148regulation of mitotic spindle checkpoint (GO:1903504)2.39296573
149protein K6-linked ubiquitination (GO:0085020)2.38868181
150detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38430013
151female gonad development (GO:0008585)2.36732596
152somatic hypermutation of immunoglobulin genes (GO:0016446)2.36059695
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.36059695
154regulation of acyl-CoA biosynthetic process (GO:0050812)2.35758207
155indolalkylamine metabolic process (GO:0006586)2.35707884
156protein K11-linked deubiquitination (GO:0035871)2.35342543
157endocrine pancreas development (GO:0031018)2.34506583
158limb bud formation (GO:0060174)2.33456638
159anterior/posterior axis specification, embryo (GO:0008595)2.33181699
160regulation of meiosis I (GO:0060631)2.32765202
161positive regulation of histone H3-K4 methylation (GO:0051571)2.31924530
162L-ascorbic acid metabolic process (GO:0019852)2.31729935
163nephron epithelium morphogenesis (GO:0072088)2.30017079
164nephron tubule morphogenesis (GO:0072078)2.30017079
165exogenous drug catabolic process (GO:0042738)2.29518959
166sphingomyelin metabolic process (GO:0006684)2.26957159
167protein complex biogenesis (GO:0070271)2.26008207
168iron coordination entity transport (GO:1901678)2.25748867
169regulation of mesoderm development (GO:2000380)2.25621816
170cobalamin metabolic process (GO:0009235)2.24922330
171peptidyl-cysteine modification (GO:0018198)2.23405487
172mannosylation (GO:0097502)2.22607860
173phenylpropanoid metabolic process (GO:0009698)2.21487162
174polyol catabolic process (GO:0046174)2.19679522
175negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.19462412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.64074005
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.05954285
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.41081066
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.31265945
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.05810501
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.93477647
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.67311289
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06004204
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80873313
10ZNF274_21170338_ChIP-Seq_K562_Hela2.72625109
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.69765949
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.67828988
13* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.60447841
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.49050889
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48738100
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.39204816
17FUS_26573619_Chip-Seq_HEK293_Human2.38748113
18VDR_22108803_ChIP-Seq_LS180_Human2.36219498
19GATA4_25053715_ChIP-Seq_YYC3_Human2.35750744
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30419881
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.29754550
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18557669
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18211166
24SOX2_20726797_ChIP-Seq_SW620_Human2.16767711
25GBX2_23144817_ChIP-Seq_PC3_Human2.16181501
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15597518
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15594877
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12722170
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.12232996
30ESR1_20079471_ChIP-ChIP_T-47D_Human2.11824154
31ESR2_21235772_ChIP-Seq_MCF-7_Human2.08444664
32P300_19829295_ChIP-Seq_ESCs_Human2.05996959
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00665439
34* EWS_26573619_Chip-Seq_HEK293_Human1.99320183
35* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.97439780
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92237803
37CLOCK_20551151_ChIP-Seq_293T_Human1.90893129
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88957146
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87043343
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.83861069
41IGF1R_20145208_ChIP-Seq_DFB_Human1.80039713
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.79747682
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.79072719
44TAF15_26573619_Chip-Seq_HEK293_Human1.79001083
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76178878
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73736495
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70935010
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70488436
49ZNF263_19887448_ChIP-Seq_K562_Human1.69806932
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68125657
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61650526
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60542142
53ER_23166858_ChIP-Seq_MCF-7_Human1.59295111
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59098148
55* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.57890306
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54889168
57ELK1_19687146_ChIP-ChIP_HELA_Human1.54312518
58GATA6_25053715_ChIP-Seq_YYC3_Human1.51575452
59* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51359883
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51271592
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51271592
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49705013
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.49298317
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.48443902
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.48381400
66TCF4_22108803_ChIP-Seq_LS180_Human1.47131384
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.44595660
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43644789
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43595267
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.43410055
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.43170434
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41214453
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39559821
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38826171
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37512726
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36201679
77SMAD4_21799915_ChIP-Seq_A2780_Human1.35404481
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34723644
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33510889
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32959562
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32199937
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31408573
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31098159
84AR_25329375_ChIP-Seq_VCAP_Human1.30895763
85SOX2_19829295_ChIP-Seq_ESCs_Human1.30308302
86NANOG_19829295_ChIP-Seq_ESCs_Human1.30308302
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30030949
88* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29871621
89CBP_20019798_ChIP-Seq_JUKART_Human1.27979778
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27979778
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.27643565
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.26049849
93* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25502410
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24985293
95* STAT3_23295773_ChIP-Seq_U87_Human1.24726442
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24591673
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24166013
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23969272
99GATA3_24758297_ChIP-Seq_MCF-7_Human1.23706657
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23307879
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23280728
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22173997
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22133089
104AHR_22903824_ChIP-Seq_MCF-7_Human1.21804138
105CJUN_26792858_Chip-Seq_BT549_Human1.21184832
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21073586
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.21056990
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20283149
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19313646
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18894058
111FOXA1_25552417_ChIP-Seq_VCAP_Human1.18502369
112GATA1_22025678_ChIP-Seq_K562_Human1.17941072
113* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17731124
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.16233335
115EST1_17652178_ChIP-ChIP_JURKAT_Human1.15974872
116* FOXA1_25329375_ChIP-Seq_VCAP_Human1.15827325
117* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15827325
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.14965877
119TCF4_23295773_ChIP-Seq_U87_Human1.14177488
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.13969953
121P53_22387025_ChIP-Seq_ESCs_Mouse1.13256821
122RUNX2_22187159_ChIP-Seq_PCA_Human1.13176449
123P300_18555785_Chip-Seq_ESCs_Mouse1.12124639
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.11162469
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10302427
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10126010
127RUNX1_27514584_Chip-Seq_MCF-7_Human1.09353130
128RXR_22108803_ChIP-Seq_LS180_Human1.08450841
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07741754
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06934152
131* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06289408
132STAT3_18555785_Chip-Seq_ESCs_Mouse1.06191075
133* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05215202
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04488150
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04153559
136NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04014841
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04014841
138SOX2_18555785_Chip-Seq_ESCs_Mouse1.04005941
139P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03444988
140* CDX2_22108803_ChIP-Seq_LS180_Human1.02701134
141ARNT_22903824_ChIP-Seq_MCF-7_Human1.02322741
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01169201
143TP63_23658742_ChIP-Seq_EP156T_Human0.97909933
144AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97375679
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97285194
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96827186
147KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96756264
148* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95973028
149KLF5_25053715_ChIP-Seq_YYC3_Human0.93171093
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92192041
151AR_21909140_ChIP-Seq_LNCAP_Human0.90931271
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90342374
153NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87886738
154BCAT_22108803_ChIP-Seq_LS180_Human0.87146137
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81557484
156* CEBPB_22108803_ChIP-Seq_LS180_Human0.80696808
157PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79524429
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79412596
159KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79083998
160KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79083998
161KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79083998
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78318757
163GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77919845
164EP300_21415370_ChIP-Seq_HL-1_Mouse0.76025675
165FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75741232
166SMAD3_21741376_ChIP-Seq_HESCs_Human0.74497268
167TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73794265
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72609292
169BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71786305
170TP53_18474530_ChIP-ChIP_U2OS_Human0.70979992
171TCF3_18692474_ChIP-Seq_MESCs_Mouse0.70601990
172EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.70227928
173TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69707440
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.69493369
175CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69159918
176GATA2_19941826_ChIP-Seq_K562_Human0.69059787
177STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.68666900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.75392485
2MP0005085_abnormal_gallbladder_physiolo4.53811581
3MP0010234_abnormal_vibrissa_follicle4.50791255
4MP0002139_abnormal_hepatobiliary_system4.37518951
5MP0005365_abnormal_bile_salt3.79945980
6MP0008875_abnormal_xenobiotic_pharmacok3.31383479
7MP0008004_abnormal_stomach_pH3.21979526
8MP0001666_abnormal_nutrient_absorption3.10370181
9MP0002796_impaired_skin_barrier3.00839933
10MP0008877_abnormal_DNA_methylation2.82282997
11MP0004019_abnormal_vitamin_homeostasis2.80496041
12MP0009379_abnormal_foot_pigmentation2.41837714
13MP0003252_abnormal_bile_duct2.38159113
14MP0010329_abnormal_lipoprotein_level2.27438526
15MP0003941_abnormal_skin_development2.23058714
16MP0004264_abnormal_extraembryonic_tissu2.18087227
17MP0002098_abnormal_vibrissa_morphology2.12699930
18MP0003890_abnormal_embryonic-extraembry2.08763261
19MP0008057_abnormal_DNA_replication2.07733793
20MP0002138_abnormal_hepatobiliary_system2.06604815
21MP0003878_abnormal_ear_physiology2.01161310
22MP0005377_hearing/vestibular/ear_phenot2.01161310
23MP0005167_abnormal_blood-brain_barrier1.96735622
24MP0010678_abnormal_skin_adnexa1.92623269
25MP0009840_abnormal_foam_cell1.92327105
26MP0003787_abnormal_imprinting1.91264159
27MP0005083_abnormal_biliary_tract1.87056354
28MP0003806_abnormal_nucleotide_metabolis1.84798861
29MP0002938_white_spotting1.83255107
30MP0005379_endocrine/exocrine_gland_phen1.82494549
31MP0005501_abnormal_skin_physiology1.76547279
32MP0004782_abnormal_surfactant_physiolog1.76411317
33MP0002254_reproductive_system_inflammat1.74440618
34MP0009384_cardiac_valve_regurgitation1.73974665
35MP0003191_abnormal_cellular_cholesterol1.71656701
36MP0002837_dystrophic_cardiac_calcinosis1.70886387
37MP0005408_hypopigmentation1.69458792
38MP0010368_abnormal_lymphatic_system1.68112575
39MP0001346_abnormal_lacrimal_gland1.67605324
40MP0005084_abnormal_gallbladder_morpholo1.66011146
41MP0008058_abnormal_DNA_repair1.60589759
42MP0005332_abnormal_amino_acid1.60429428
43MP0000427_abnormal_hair_cycle1.60220354
44MP0005551_abnormal_eye_electrophysiolog1.58557382
45MP0004133_heterotaxia1.52019187
46MP0002163_abnormal_gland_morphology1.51474125
47MP0000566_synostosis1.51181259
48MP0004147_increased_porphyrin_level1.48409874
49MP0002160_abnormal_reproductive_system1.46832057
50MP0003300_gastrointestinal_ulcer1.46235019
51MP0009643_abnormal_urine_homeostasis1.44944347
52MP0004272_abnormal_basement_membrane1.43685324
53MP0004381_abnormal_hair_follicle1.41911660
54MP0002102_abnormal_ear_morphology1.41129441
55MP0003195_calcinosis1.38975070
56MP0002009_preneoplasia1.38831025
57MP0003693_abnormal_embryo_hatching1.36300203
58MP0001879_abnormal_lymphatic_vessel1.35200361
59MP0006072_abnormal_retinal_apoptosis1.35198128
60MP0010352_gastrointestinal_tract_polyps1.35106449
61MP0001188_hyperpigmentation1.34441217
62MP0005645_abnormal_hypothalamus_physiol1.33403581
63MP0003121_genomic_imprinting1.30246771
64MP0000537_abnormal_urethra_morphology1.29777342
65MP0003122_maternal_imprinting1.29180032
66MP0001485_abnormal_pinna_reflex1.28755525
67MP0002909_abnormal_adrenal_gland1.27169196
68MP0003123_paternal_imprinting1.27079000
69MP0003283_abnormal_digestive_organ1.26878504
70MP0005646_abnormal_pituitary_gland1.24927386
71MP0003453_abnormal_keratinocyte_physiol1.24598050
72MP0003718_maternal_effect1.24200286
73MP0001944_abnormal_pancreas_morphology1.20075526
74MP0000383_abnormal_hair_follicle1.19648505
75MP0008872_abnormal_physiological_respon1.19473572
76MP0005647_abnormal_sex_gland1.18686180
77MP0006292_abnormal_olfactory_placode1.18671506
78MP0005451_abnormal_body_composition1.16405085
79MP0006054_spinal_hemorrhage1.16286992
80MP0002928_abnormal_bile_duct1.16264094
81MP0001756_abnormal_urination1.14597680
82MP0001764_abnormal_homeostasis1.14530964
83MP0001216_abnormal_epidermal_layer1.14357107
84MP0003786_premature_aging1.13548706
85MP0003937_abnormal_limbs/digits/tail_de1.12079824
86MP0000631_abnormal_neuroendocrine_gland1.12066356
87MP0005636_abnormal_mineral_homeostasis1.10762080
88MP0003119_abnormal_digestive_system1.09292833
89MP0000377_abnormal_hair_follicle1.08291617
90MP0000609_abnormal_liver_physiology1.07984930
91MP0005389_reproductive_system_phenotype1.07627287
92MP0004043_abnormal_pH_regulation1.06481671
93MP0002118_abnormal_lipid_homeostasis1.05422932
94MP0009697_abnormal_copulation1.05403867
95MP0001984_abnormal_olfaction1.04285374
96MP0002090_abnormal_vision1.02950233
97MP0003011_delayed_dark_adaptation1.02215492
98MP0002876_abnormal_thyroid_physiology1.01357762
99MP0000372_irregular_coat_pigmentation1.01087276
100MP0000462_abnormal_digestive_system1.00528550
101MP0005253_abnormal_eye_physiology0.99625717
102MP0003943_abnormal_hepatobiliary_system0.94615077
103MP0005248_abnormal_Harderian_gland0.94565510
104MP0003868_abnormal_feces_composition0.93738937
105MP0002060_abnormal_skin_morphology0.93329429
106MP0005187_abnormal_penis_morphology0.90624093
107MP0005220_abnormal_exocrine_pancreas0.90524388
108MP0006138_congestive_heart_failure0.89234379
109MP0001765_abnormal_ion_homeostasis0.88871977
110MP0002136_abnormal_kidney_physiology0.88118623
111MP0010771_integument_phenotype0.85638768
112MP0002233_abnormal_nose_morphology0.85214031
113MP0002693_abnormal_pancreas_physiology0.83538942
114MP0008995_early_reproductive_senescence0.82874283
115MP0000516_abnormal_urinary_system0.82661202
116MP0005367_renal/urinary_system_phenotyp0.82661202
117MP0005165_increased_susceptibility_to0.82513661
118MP0002277_abnormal_respiratory_mucosa0.82451584
119MP0005319_abnormal_enzyme/_coenzyme0.82386178
120MP0001664_abnormal_digestion0.82237719
121MP0000467_abnormal_esophagus_morphology0.82139987
122MP0010094_abnormal_chromosome_stability0.78900357
123MP0010386_abnormal_urinary_bladder0.77935603
124* MP0000613_abnormal_salivary_gland0.77764740
125MP0000579_abnormal_nail_morphology0.76846364
126MP0003936_abnormal_reproductive_system0.76596137
127MP0002638_abnormal_pupillary_reflex0.76261859
128MP0000538_abnormal_urinary_bladder0.76002912
129MP0001293_anophthalmia0.75815026
130MP0003638_abnormal_response/metabolism_0.74465793
131* MP0000653_abnormal_sex_gland0.74107116
132MP0001919_abnormal_reproductive_system0.73499545
133MP0003705_abnormal_hypodermis_morpholog0.72574103
134MP0004215_abnormal_myocardial_fiber0.72343765
135MP0005395_other_phenotype0.71138555
136MP0001929_abnormal_gametogenesis0.70993188
137MP0004957_abnormal_blastocyst_morpholog0.70916021
138MP0003186_abnormal_redox_activity0.69613843
139MP0001286_abnormal_eye_development0.68558732
140MP0005275_abnormal_skin_tensile0.67903631
141* MP0001145_abnormal_male_reproductive0.67749559
142MP0002751_abnormal_autonomic_nervous0.67633158
143MP0003567_abnormal_fetal_cardiomyocyte0.67158518
144MP0003866_abnormal_defecation0.66844325
145* MP0001873_stomach_inflammation0.66048845
146MP0002132_abnormal_respiratory_system0.65199271
147MP0002166_altered_tumor_susceptibility0.65198403
148MP0010155_abnormal_intestine_physiology0.63704497
149MP0000647_abnormal_sebaceous_gland0.62636821
150MP0004947_skin_inflammation0.60970398
151* MP0000470_abnormal_stomach_morphology0.60658334
152MP0009780_abnormal_chondrocyte_physiolo0.60573014
153MP0009764_decreased_sensitivity_to0.60367321
154MP0000762_abnormal_tongue_morphology0.60325732
155MP0001191_abnormal_skin_condition0.60171609
156MP0000477_abnormal_intestine_morphology0.59469049

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.24394305
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.45228539
3Hypoglycemic coma (HP:0001325)4.24821881
4Right ventricular cardiomyopathy (HP:0011663)4.22709752
5Prolonged partial thromboplastin time (HP:0003645)4.22448499
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.91765196
7Fat malabsorption (HP:0002630)3.83740864
8Xanthomatosis (HP:0000991)3.71269193
9Hyperglycinuria (HP:0003108)3.70409410
10Conjugated hyperbilirubinemia (HP:0002908)3.67067455
11Hypobetalipoproteinemia (HP:0003563)3.66606746
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65589240
13Ileus (HP:0002595)3.65444792
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.65110559
15Hypoglycemic seizures (HP:0002173)3.64801820
16Deep venous thrombosis (HP:0002625)3.62035860
17Onycholysis (HP:0001806)3.61305627
18Chronic bronchitis (HP:0004469)3.56291026
19Esophageal varix (HP:0002040)3.52940004
20Hyperactive renin-angiotensin system (HP:0000841)3.51176638
21Abnormal respiratory motile cilium physiology (HP:0012261)3.35309028
22Symptomatic seizures (HP:0011145)3.33321775
23Hyperinsulinemic hypoglycemia (HP:0000825)3.29238636
24Abnormality of serine family amino acid metabolism (HP:0010894)3.05657658
25Abnormality of glycine metabolism (HP:0010895)3.05657658
26Intestinal atresia (HP:0011100)3.02242032
27Gout (HP:0001997)3.00270987
28Hypothermia (HP:0002045)2.96431364
29Pancreatic cysts (HP:0001737)2.91160742
30Abnormality of vitamin B metabolism (HP:0004340)2.88743742
31Hypolipoproteinemia (HP:0010981)2.88566633
32Hypoplasia of the uterus (HP:0000013)2.86576925
33Male infertility (HP:0003251)2.86511633
34Abnormality of chloride homeostasis (HP:0011422)2.86437197
35Abnormal ciliary motility (HP:0012262)2.84464131
36Vascular calcification (HP:0004934)2.80940194
37Rhinitis (HP:0012384)2.79810352
38Methylmalonic acidemia (HP:0002912)2.76807977
39Abnormality of the common coagulation pathway (HP:0010990)2.75171846
40Hyperglycinemia (HP:0002154)2.72663625
41Abnormality of the intrinsic pathway (HP:0010989)2.69064911
42Hyperammonemia (HP:0001987)2.67677253
43Steatorrhea (HP:0002570)2.63937166
44Joint hemorrhage (HP:0005261)2.59514313
45Abnormality of purine metabolism (HP:0004352)2.58854328
46Epidermoid cyst (HP:0200040)2.58200382
47Malnutrition (HP:0004395)2.57926218
48Ventricular fibrillation (HP:0001663)2.54422663
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.47208308
50Hypoalphalipoproteinemia (HP:0003233)2.45809005
51Breast carcinoma (HP:0003002)2.45565059
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.44386191
53True hermaphroditism (HP:0010459)2.43033494
54Hyperlipoproteinemia (HP:0010980)2.40391266
55Absent eyebrow (HP:0002223)2.39787102
56Complement deficiency (HP:0004431)2.38958261
57Cardiovascular calcification (HP:0011915)2.37864460
58Pancreatic fibrosis (HP:0100732)2.37233721
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36034314
60Abnormality of midbrain morphology (HP:0002418)2.35500444
61Molar tooth sign on MRI (HP:0002419)2.35500444
62Woolly hair (HP:0002224)2.31643355
63Abnormality of fatty-acid metabolism (HP:0004359)2.30834629
64Congenital malformation of the right heart (HP:0011723)2.30684384
65Double outlet right ventricle (HP:0001719)2.30684384
66Hydroxyprolinuria (HP:0003080)2.29719636
67Abnormality of proline metabolism (HP:0010907)2.29719636
68Aplasia/hypoplasia of the uterus (HP:0008684)2.28732910
69Abnormality of methionine metabolism (HP:0010901)2.26549414
70Abnormality of vitamin metabolism (HP:0100508)2.26513508
71Abnormality of the labia minora (HP:0012880)2.25952953
72Abnormal biliary tract physiology (HP:0012439)2.23676243
73Bile duct proliferation (HP:0001408)2.23676243
74Nephronophthisis (HP:0000090)2.23370594
75Abnormality of nucleobase metabolism (HP:0010932)2.22957035
76Tubular atrophy (HP:0000092)2.22829514
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.21922437
78Methylmalonic aciduria (HP:0012120)2.19330281
79Ketoacidosis (HP:0001993)2.18738668
80Ketosis (HP:0001946)2.18584742
81Congenital, generalized hypertrichosis (HP:0004540)2.18059189
82Neoplasm of the adrenal cortex (HP:0100641)2.17931753
83Abnormality of the axillary hair (HP:0100134)2.17466163
84Abnormality of secondary sexual hair (HP:0009888)2.17466163
85Renal cortical cysts (HP:0000803)2.17216077
86Abnormal pancreas size (HP:0012094)2.16163079
87Dehydration (HP:0001944)2.15222041
88Colon cancer (HP:0003003)2.14897036
89Proximal tubulopathy (HP:0000114)2.14110576
90Metabolic alkalosis (HP:0200114)2.09971109
91Alkalosis (HP:0001948)2.09451033
92Increased purine levels (HP:0004368)2.07850687
93Hyperuricemia (HP:0002149)2.07850687
94Tetany (HP:0001281)2.07811456
95Abnormality of the renal medulla (HP:0100957)2.07306453
96Aqueductal stenosis (HP:0002410)2.05567401
97Congenital ichthyosiform erythroderma (HP:0007431)2.04346334
98Hypercholesterolemia (HP:0003124)2.03938328
99Portal hypertension (HP:0001409)1.99463701
100Abdominal distention (HP:0003270)1.99098543
101Abnormality of urine glucose concentration (HP:0011016)1.98010930
102Glycosuria (HP:0003076)1.98010930
103Plantar hyperkeratosis (HP:0007556)1.97869557
104Progressive inability to walk (HP:0002505)1.97269431
105Potter facies (HP:0002009)1.95176463
106Facial shape deformation (HP:0011334)1.95176463
107Neoplasm of the adrenal gland (HP:0100631)1.94968980
108Tubulointerstitial nephritis (HP:0001970)1.94718674
109Hemorrhage of the eye (HP:0011885)1.94534577
110Hepatocellular carcinoma (HP:0001402)1.94277786
111Pancreatic islet-cell hyperplasia (HP:0004510)1.94100812
112Abnormality of the gastric mucosa (HP:0004295)1.93857271
113Hyperglycemia (HP:0003074)1.93578674
114Medial flaring of the eyebrow (HP:0010747)1.93093256
115Sensorimotor neuropathy (HP:0007141)1.92268067
116Abolished electroretinogram (ERG) (HP:0000550)1.91420748
117Gonadotropin excess (HP:0000837)1.90821097
118Congenital stationary night blindness (HP:0007642)1.90633440
119Abnormal biliary tract morphology (HP:0012440)1.90629899
120Curly hair (HP:0002212)1.89920679
121Pili torti (HP:0003777)1.88689988
122Bronchiectasis (HP:0002110)1.86329136
123Hypokalemic alkalosis (HP:0001949)1.85722830
124Labial hypoplasia (HP:0000066)1.85660986
125Polycythemia (HP:0001901)1.85307966
126Biliary tract neoplasm (HP:0100574)1.84886092
127Cone-rod dystrophy (HP:0000548)1.84743764
128Abnormality of serum amino acid levels (HP:0003112)1.84675716
129Abnormality of the nasal septum (HP:0000419)1.84263562
130Gastrointestinal atresia (HP:0002589)1.83655283
131Abnormality of the renal cortex (HP:0011035)1.83516691
132Fragile nails (HP:0001808)1.83484331
133Alopecia of scalp (HP:0002293)1.82975793
134Abnormality of renal excretion (HP:0011036)1.82843926
135Aplasia/Hypoplasia of the spleen (HP:0010451)1.82473317
136Hypomagnesemia (HP:0002917)1.82003719
137Tubulointerstitial fibrosis (HP:0005576)1.80957076
138Attenuation of retinal blood vessels (HP:0007843)1.80172085
139Azoospermia (HP:0000027)1.76701922
140Hepatic necrosis (HP:0002605)1.75603484
141Genital tract atresia (HP:0001827)1.75057992
142Chronic hepatic failure (HP:0100626)1.74834004
143Abnormal albumin level (HP:0012116)1.74782672
144Hypoalbuminemia (HP:0003073)1.74782672
145Acute encephalopathy (HP:0006846)1.74667210
146Concave nail (HP:0001598)1.73381821
147Abnormality of the pons (HP:0007361)1.73067759
148Ependymoma (HP:0002888)1.72089805
149Spontaneous abortion (HP:0005268)1.71788523
150Pendular nystagmus (HP:0012043)1.71563104
151Abnormality of chromosome stability (HP:0003220)1.71353682
152Anophthalmia (HP:0000528)1.70269290
153Vaginal atresia (HP:0000148)1.67665495
154Hypoplastic female external genitalia (HP:0012815)1.67492626
155Bifid tongue (HP:0010297)1.66353693
156Large for gestational age (HP:0001520)1.65558160
157Abnormality of the parathyroid morphology (HP:0011766)1.65394005
158Abnormal rod and cone electroretinograms (HP:0008323)1.65251793
159Hypoplastic labia majora (HP:0000059)1.64485657
160Gaze-evoked nystagmus (HP:0000640)1.64014760
161Increased CSF lactate (HP:0002490)1.63243851
162Cystic liver disease (HP:0006706)1.63214572
163Lethargy (HP:0001254)1.62563286
164Stenosis of the external auditory canal (HP:0000402)1.61217098
165Abnormality of macular pigmentation (HP:0008002)1.60409834
166Amelogenesis imperfecta (HP:0000705)1.59900457
167Furrowed tongue (HP:0000221)1.59852856
168Megaloblastic anemia (HP:0001889)1.59119654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.60961135
2MST44.40171876
3EPHA24.28703223
4FRK3.80080240
5TNIK3.00667188
6MST1R2.89166654
7TRIM282.75850763
8MAPK152.75071014
9INSRR2.58886450
10AKT32.56725448
11MKNK22.54286199
12WNK32.53772887
13ACVR1B2.32195416
14LMTK22.29680366
15BMPR1B2.24279002
16MAP4K22.20066339
17KDR2.16663396
18MAP2K22.13736422
19LATS12.13404593
20EIF2AK31.87922012
21FER1.87891817
22CASK1.73187574
23STK241.71484078
24WEE11.70785644
25PTK61.68218589
26PNCK1.67726759
27MAPKAPK31.60596908
28NLK1.51550867
29STK391.49069032
30NUAK11.43419320
31TEC1.39262163
32MKNK11.38943408
33MAP3K31.37498647
34RPS6KB21.36117292
35EPHB21.33923422
36PLK31.30618647
37TAF11.29593688
38MAP3K121.29520105
39FGFR41.28890663
40BCR1.23850985
41PRKG21.21925957
42ADRBK21.21368850
43CAMK1D1.18661679
44TGFBR21.18367174
45BMX1.17267821
46MAP3K21.15909284
47BCKDK1.12125396
48VRK21.11761510
49IRAK31.11692528
50MET1.11465661
51TRPM71.08737192
52PBK1.07073546
53SIK10.98349372
54CSNK1G10.98292986
55TAOK30.97802538
56STK100.97592853
57PTK20.95627044
58PRKAA20.93152649
59WNK40.92333991
60VRK10.91564038
61RIPK10.91065296
62TSSK60.89460870
63EIF2AK10.88889671
64CDK60.85627138
65MAP3K40.83935216
66STK38L0.81116317
67NEK90.79613700
68SRPK10.79193576
69PRKD30.76189968
70MAPK130.76039240
71PLK40.73113045
72PLK10.71783071
73PHKG20.71478164
74PHKG10.71478164
75PLK20.71146466
76CSNK1G20.71123534
77PRKCI0.71103191
78OXSR10.70678468
79MYLK0.70647081
80BUB10.68375669
81ERBB40.68061538
82MAP2K10.67268587
83CSNK1G30.67147901
84LRRK20.66449300
85FGFR10.66071273
86SIK30.64859192
87PAK40.62135472
88CAMK1G0.61545677
89BRSK10.61202011
90EEF2K0.59301307
91DYRK1B0.58382554
92ERN10.57802574
93NEK10.56688392
94EPHB10.56670234
95GSK3A0.55430203
96CDC70.55110618
97ERBB20.53350384
98PDK20.52405709
99EPHA30.51596901
100ATM0.48809559
101DAPK20.47503923
102CSNK1A10.45658914
103MAPK110.45205262
104EIF2AK20.43372083
105STK160.42806844
106IGF1R0.42094190
107CAMK2D0.41043625
108SGK20.38334759
109MELK0.37847937
110PIK3CG0.36135132
111ERBB30.35756845
112FGFR20.35274509
113STK30.35154645
114MAP2K60.34897801
115EPHA40.34799883
116AURKB0.34736419
117PRKAA10.32807205
118RPS6KB10.32769848
119DYRK30.32576156
120CSNK1D0.32063700
121PINK10.31900058
122YES10.31007376
123NME10.30362100
124MAPK70.30304676
125FLT30.29366997
126AKT20.29299901
127NEK60.28757390
128ATR0.28555702
129* CSNK1E0.28443336
130* PRKCG0.28217665
131MAP3K90.28059815
132EGFR0.27756529
133* GRK10.27452823
134DYRK20.27400773
135BRD40.26531357
136ZAK0.26211711
137CAMK2G0.25457671
138PIM20.25430213
139BRSK20.23838718
140CHUK0.23465207
141FGFR30.23240568
142CDK90.23089660
143SGK4940.22851854
144SGK2230.22851854
145SGK30.22098139
146* PRKCE0.21508092
147PIK3CA0.21255727
148TGFBR10.20866570
149* PRKCA0.20212412
150MAP3K140.19362221
151PDPK10.18773593
152MAPKAPK20.17154383
153TTK0.17044035
154PAK30.16173700
155AURKA0.15939257
156CSNK1A1L0.15415786
157IRAK10.15141215
158ABL10.14359559

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.34829630
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.98422723
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.97224821
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.76450374
5Histidine metabolism_Homo sapiens_hsa003402.57067663
6Vitamin digestion and absorption_Homo sapiens_hsa049772.45260754
7Protein export_Homo sapiens_hsa030602.42181762
8Sulfur metabolism_Homo sapiens_hsa009202.38034767
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32905256
10Arginine biosynthesis_Homo sapiens_hsa002202.32727835
11Tryptophan metabolism_Homo sapiens_hsa003802.30898184
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.29910542
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.27392775
14Bile secretion_Homo sapiens_hsa049762.24046608
15Fat digestion and absorption_Homo sapiens_hsa049752.23830064
16Mineral absorption_Homo sapiens_hsa049782.11077087
17Fatty acid degradation_Homo sapiens_hsa000712.05733430
18Chemical carcinogenesis_Homo sapiens_hsa052042.04485807
19Retinol metabolism_Homo sapiens_hsa008301.99709502
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97024505
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89359029
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88558284
23Complement and coagulation cascades_Homo sapiens_hsa046101.87058274
24PPAR signaling pathway_Homo sapiens_hsa033201.80868147
25Non-homologous end-joining_Homo sapiens_hsa034501.77726592
26Folate biosynthesis_Homo sapiens_hsa007901.70175888
27Phenylalanine metabolism_Homo sapiens_hsa003601.69638123
28beta-Alanine metabolism_Homo sapiens_hsa004101.68528352
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.66369506
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59863270
31Peroxisome_Homo sapiens_hsa041461.56511797
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54652133
33Butanoate metabolism_Homo sapiens_hsa006501.53654582
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.48290974
35Starch and sucrose metabolism_Homo sapiens_hsa005001.45305298
36Caffeine metabolism_Homo sapiens_hsa002321.45082882
37Homologous recombination_Homo sapiens_hsa034401.44614784
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44525520
39ABC transporters_Homo sapiens_hsa020101.43804757
40Propanoate metabolism_Homo sapiens_hsa006401.42190756
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37752162
42Vitamin B6 metabolism_Homo sapiens_hsa007501.34228445
43Ether lipid metabolism_Homo sapiens_hsa005651.32248489
44Basal transcription factors_Homo sapiens_hsa030221.31741471
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30695564
46Tyrosine metabolism_Homo sapiens_hsa003501.26457437
47Glutathione metabolism_Homo sapiens_hsa004801.24961477
48Selenocompound metabolism_Homo sapiens_hsa004501.24534283
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22661130
50Phototransduction_Homo sapiens_hsa047441.20559870
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20263495
52Proteasome_Homo sapiens_hsa030501.18867045
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17857581
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.16627545
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16565238
56Fanconi anemia pathway_Homo sapiens_hsa034601.14866832
57Arginine and proline metabolism_Homo sapiens_hsa003301.14281462
58RNA degradation_Homo sapiens_hsa030181.11528569
59Fatty acid metabolism_Homo sapiens_hsa012121.09792173
60Sphingolipid metabolism_Homo sapiens_hsa006001.07591550
61RNA polymerase_Homo sapiens_hsa030201.06248678
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05037101
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03497859
64One carbon pool by folate_Homo sapiens_hsa006701.03105668
65Fructose and mannose metabolism_Homo sapiens_hsa000511.01068868
66Adherens junction_Homo sapiens_hsa045200.98556032
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98400273
68Protein digestion and absorption_Homo sapiens_hsa049740.97935693
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97595225
70Fatty acid elongation_Homo sapiens_hsa000620.92365163
71Renin-angiotensin system_Homo sapiens_hsa046140.90340729
72Oxidative phosphorylation_Homo sapiens_hsa001900.89889186
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89244666
74Mismatch repair_Homo sapiens_hsa034300.84738932
75Glycerolipid metabolism_Homo sapiens_hsa005610.84498305
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78195266
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76912709
78RNA transport_Homo sapiens_hsa030130.73273750
79Staphylococcus aureus infection_Homo sapiens_hsa051500.72381808
80Circadian rhythm_Homo sapiens_hsa047100.69823649
81Galactose metabolism_Homo sapiens_hsa000520.69487857
82* Tight junction_Homo sapiens_hsa045300.67923048
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.66101446
84Pyruvate metabolism_Homo sapiens_hsa006200.63274975
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61592374
86Pancreatic secretion_Homo sapiens_hsa049720.61442862
87Sulfur relay system_Homo sapiens_hsa041220.60839062
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60273413
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59131331
90Insulin secretion_Homo sapiens_hsa049110.56964833
91Steroid biosynthesis_Homo sapiens_hsa001000.54913968
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54388120
93Ovarian steroidogenesis_Homo sapiens_hsa049130.54209609
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53725495
95Arachidonic acid metabolism_Homo sapiens_hsa005900.51236836
96Carbon metabolism_Homo sapiens_hsa012000.50721528
97Purine metabolism_Homo sapiens_hsa002300.50699678
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50443152
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.49311054
100Linoleic acid metabolism_Homo sapiens_hsa005910.49286307
101Biosynthesis of amino acids_Homo sapiens_hsa012300.47294774
102Nucleotide excision repair_Homo sapiens_hsa034200.44687639
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44554592
104Parkinsons disease_Homo sapiens_hsa050120.44262291
105Metabolic pathways_Homo sapiens_hsa011000.44115413
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42162742
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41057621
108Regulation of autophagy_Homo sapiens_hsa041400.40799821
109Pentose phosphate pathway_Homo sapiens_hsa000300.40753052
110Thyroid hormone synthesis_Homo sapiens_hsa049180.38928189
111N-Glycan biosynthesis_Homo sapiens_hsa005100.37652385
112Glucagon signaling pathway_Homo sapiens_hsa049220.34189552
113Fatty acid biosynthesis_Homo sapiens_hsa000610.30947521
114Hippo signaling pathway_Homo sapiens_hsa043900.30643690
115Lysine degradation_Homo sapiens_hsa003100.29978767
116* Leukocyte transendothelial migration_Homo sapiens_hsa046700.29237851
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24609099
118Gastric acid secretion_Homo sapiens_hsa049710.23418076
119Basal cell carcinoma_Homo sapiens_hsa052170.18253589
120* Hepatitis C_Homo sapiens_hsa051600.17144479
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14697517
122Insulin resistance_Homo sapiens_hsa049310.14253487
123Bladder cancer_Homo sapiens_hsa052190.14137741
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13534501
125TGF-beta signaling pathway_Homo sapiens_hsa043500.13155537
126ECM-receptor interaction_Homo sapiens_hsa045120.11121595
127Prostate cancer_Homo sapiens_hsa052150.09898389
128Small cell lung cancer_Homo sapiens_hsa052220.09870246

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