OCSTAMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is orthologous to the mouse osteoclast stimulatory transmembrane protein (OCSTAMP), which is a membrane-anchored cell surface receptor that promotes nucleation of osteoclasts. The mouse protein is also involved in bone resorption and osteoclast differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide catabolic process (GO:0009313)6.30511178
2* positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)6.24369744
3regulation of vitamin D biosynthetic process (GO:0060556)5.60709409
4regulation of monocyte differentiation (GO:0045655)5.40198650
5positive regulation of bone resorption (GO:0045780)5.22405674
6positive regulation of bone remodeling (GO:0046852)5.22405674
7superoxide anion generation (GO:0042554)5.13580535
8amino sugar catabolic process (GO:0046348)4.73623659
9regulation of cholesterol storage (GO:0010885)4.67141433
10myeloid dendritic cell differentiation (GO:0043011)4.50508167
11decidualization (GO:0046697)4.48940919
12cellular response to thyroid hormone stimulus (GO:0097067)4.42126958
13* osteoclast differentiation (GO:0030316)4.40536813
14regulation of vitamin metabolic process (GO:0030656)4.36885244
15* regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.31740921
16modulation by symbiont of host defense response (GO:0052031)4.30103573
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30103573
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30103573
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.30103573
20modulation by symbiont of host immune response (GO:0052553)4.30103573
21positive regulation by symbiont of host defense response (GO:0052509)4.30103573
22monocyte chemotaxis (GO:0002548)4.27713394
23negative regulation of interleukin-12 production (GO:0032695)4.24943338
24fat-soluble vitamin biosynthetic process (GO:0042362)4.24864584
25cellular extravasation (GO:0045123)4.21912070
26regulation of mononuclear cell migration (GO:0071675)4.21060834
27positive regulation of cellular amide metabolic process (GO:0034250)4.19007234
28negative regulation of mast cell activation (GO:0033004)4.09448744
29positive regulation of tissue remodeling (GO:0034105)4.03790623
30myeloid dendritic cell activation (GO:0001773)3.99335015
31lipopolysaccharide-mediated signaling pathway (GO:0031663)3.92543682
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.91932932
33response to host immune response (GO:0052572)3.91932932
34regulation of lymphocyte chemotaxis (GO:1901623)3.89616041
35membrane lipid catabolic process (GO:0046466)3.86349894
36sphingolipid catabolic process (GO:0030149)3.81216469
37detection of other organism (GO:0098543)3.66119893
38macrophage differentiation (GO:0030225)3.63878581
39eosinophil chemotaxis (GO:0048245)3.53120581
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.48525700
41response to host (GO:0075136)3.48525700
42response to host defenses (GO:0052200)3.48525700
43response to thyroid hormone (GO:0097066)3.48143674
44glucosamine-containing compound catabolic process (GO:1901072)3.46953979
45detection of molecule of bacterial origin (GO:0032490)3.43714001
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.30621355
47negative regulation of nitric oxide biosynthetic process (GO:0045019)3.29997195
48positive regulation of monocyte chemotaxis (GO:0090026)3.29552671
49startle response (GO:0001964)3.24714111
50interferon-gamma production (GO:0032609)3.23024708
51apoptotic cell clearance (GO:0043277)3.22516807
52dendritic cell differentiation (GO:0097028)3.22182237
53barbed-end actin filament capping (GO:0051016)3.21777191
54presynaptic membrane assembly (GO:0097105)3.21522823
55regulation of podosome assembly (GO:0071801)3.20301145
56microglial cell activation (GO:0001774)3.19497743
57* positive regulation of osteoclast differentiation (GO:0045672)3.15154047
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14754197
59ganglioside metabolic process (GO:0001573)3.14301783
60eosinophil migration (GO:0072677)3.12650778
61positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.11407878
62NIK/NF-kappaB signaling (GO:0038061)3.07740785
63cellular response to ethanol (GO:0071361)3.06914277
64negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.05962399
65germinal center formation (GO:0002467)3.03334163
66detection of bacterium (GO:0016045)3.02754320
67regulation of timing of cell differentiation (GO:0048505)3.02055810
68granulocyte chemotaxis (GO:0071621)3.01418749
69positive regulation of leukocyte degranulation (GO:0043302)3.01171139
70regulation of bone resorption (GO:0045124)3.00539726
71negative regulation of homotypic cell-cell adhesion (GO:0034111)3.00401833
72phagosome maturation (GO:0090382)2.99091978
73T-helper 1 type immune response (GO:0042088)2.98428558
74superoxide metabolic process (GO:0006801)2.94931713
75negative regulation of lipid storage (GO:0010888)2.94535841
76positive regulation of macrophage differentiation (GO:0045651)2.94003562
77granulocyte activation (GO:0036230)2.92777847
78prostate gland growth (GO:0060736)2.91426075
79protein localization to endosome (GO:0036010)2.90036470
80intracellular pH reduction (GO:0051452)2.89236987
81positive regulation of gamma-delta T cell activation (GO:0046645)2.89164632
82positive regulation of chemokine biosynthetic process (GO:0045080)2.88403551
83granulocyte migration (GO:0097530)2.87951640
84positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.87331867
85auditory receptor cell stereocilium organization (GO:0060088)2.87300676
86vitamin D metabolic process (GO:0042359)2.87113081
87regulation of germinal center formation (GO:0002634)2.86819763
88neutrophil chemotaxis (GO:0030593)2.86469910
89immunoglobulin mediated immune response (GO:0016064)2.86452230
90behavioral response to nicotine (GO:0035095)2.85959903
91positive regulation of NF-kappaB import into nucleus (GO:0042346)2.85408950
92inner ear receptor stereocilium organization (GO:0060122)2.84799959
93keratan sulfate catabolic process (GO:0042340)2.84635128
94pH reduction (GO:0045851)2.83643687
95positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83098077
96regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.82188972
97negative regulation of interleukin-17 production (GO:0032700)2.81891960
98regulation of platelet aggregation (GO:0090330)2.81805555
99negative regulation of monooxygenase activity (GO:0032769)2.81415753
100negative regulation of myeloid cell apoptotic process (GO:0033033)2.81379838
101pinocytosis (GO:0006907)2.80858453
102regulation of lymphocyte migration (GO:2000401)2.80652669
103regulation of mast cell activation (GO:0033003)2.79544043
104regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79254540
105neutrophil migration (GO:1990266)2.78705296
106presynaptic membrane organization (GO:0097090)2.77728526
107histone H3-K4 trimethylation (GO:0080182)2.76934291
108neutrophil mediated immunity (GO:0002446)2.76476817
109detection of external biotic stimulus (GO:0098581)2.75926055
110regulation of macrophage chemotaxis (GO:0010758)2.74710081
111regulation of activation of Janus kinase activity (GO:0010533)2.72775773
112positive regulation of interleukin-1 beta secretion (GO:0050718)2.72732543
113glycosphingolipid catabolic process (GO:0046479)2.72627611
114positive regulation of lymphocyte migration (GO:2000403)2.72417598
115respiratory burst (GO:0045730)2.72336611
116regulation of RIG-I signaling pathway (GO:0039535)2.72254788
117cellular response to lipopolysaccharide (GO:0071222)2.71857073
118regulation of macrophage derived foam cell differentiation (GO:0010743)2.71647771
119positive regulation of antigen processing and presentation (GO:0002579)2.69668483
120opioid receptor signaling pathway (GO:0038003)2.69098135
121N-acetylneuraminate metabolic process (GO:0006054)2.67640263
122dentate gyrus development (GO:0021542)2.67510597
123ceramide catabolic process (GO:0046514)2.65038350
124regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.64598508
125negative regulation of alcohol biosynthetic process (GO:1902931)2.64267497
126pyrimidine-containing compound transmembrane transport (GO:0072531)2.63996360
127cellular response to molecule of bacterial origin (GO:0071219)2.63794148
128positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.63639622
129macrophage activation involved in immune response (GO:0002281)2.62586708
130positive regulation of cholesterol efflux (GO:0010875)2.62196870
131regulation of development, heterochronic (GO:0040034)2.61373550
132positive regulation of leukocyte chemotaxis (GO:0002690)2.60372642
133negative regulation of DNA-dependent DNA replication (GO:2000104)2.59442349
134regulation of B cell receptor signaling pathway (GO:0050855)2.58236402
135regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.58072592
136regulation of mast cell activation involved in immune response (GO:0033006)2.58055496
137positive regulation of mast cell activation (GO:0033005)2.57785177
138G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.57768302
139regulation of mast cell degranulation (GO:0043304)2.57717744
140dendritic cell chemotaxis (GO:0002407)2.57209303
141energy homeostasis (GO:0097009)2.56377698
142serotonin receptor signaling pathway (GO:0007210)2.54022046
143response to peptidoglycan (GO:0032494)2.54020960
144adenosine metabolic process (GO:0046085)2.53987018
145phagocytosis, recognition (GO:0006910)2.53869719
146neutrophil activation involved in immune response (GO:0002283)2.52118662
147positive regulation of mast cell activation involved in immune response (GO:0033008)2.51018656
148positive regulation of mast cell degranulation (GO:0043306)2.51018656
149macrophage activation (GO:0042116)2.50698458
150neutrophil activation (GO:0042119)2.50453755
151hydrogen peroxide biosynthetic process (GO:0050665)2.50418366
152G-protein coupled receptor internalization (GO:0002031)2.49253124
153positive regulation of interleukin-1 secretion (GO:0050716)2.47564587
154dendritic cell migration (GO:0036336)2.45471713
155ganglion development (GO:0061548)2.44514100
156regulation of fever generation (GO:0031620)2.44011626
157daunorubicin metabolic process (GO:0044597)2.42062693
158polyketide metabolic process (GO:0030638)2.42062693
159doxorubicin metabolic process (GO:0044598)2.42062693
160histamine secretion (GO:0001821)2.41215361
161positive regulation of protein homodimerization activity (GO:0090073)2.38595345
162regulation of dendritic cell antigen processing and presentation (GO:0002604)2.36087389
163regulation of interleukin-1 beta secretion (GO:0050706)2.35844643
164diterpenoid biosynthetic process (GO:0016102)2.34317876
165reactive oxygen species biosynthetic process (GO:1903409)2.34099426
166postsynaptic membrane organization (GO:0001941)2.33551535
167transferrin transport (GO:0033572)2.33316715
168developmental pigmentation (GO:0048066)2.32518617
169photoreceptor cell maintenance (GO:0045494)2.32137889
170positive regulation of heat generation (GO:0031652)2.31492007
171glycolipid catabolic process (GO:0019377)2.31147179
172female gonad development (GO:0008585)2.29971237
173negative regulation of exocytosis (GO:0045920)2.29614133
174regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.28934273
175regulation of antigen processing and presentation (GO:0002577)2.28208598
176production of molecular mediator involved in inflammatory response (GO:0002532)2.27356860
177regulation of memory T cell differentiation (GO:0043380)2.27193055
178modulation by virus of host process (GO:0019054)2.26958682
179cerebral cortex radially oriented cell migration (GO:0021799)2.26427366
180regulation of interferon-beta biosynthetic process (GO:0045357)2.25747760
181detection of biotic stimulus (GO:0009595)2.25662661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.83931254
2GBX2_23144817_ChIP-Seq_PC3_Human4.30178691
3NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.61853655
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.34380433
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.20656598
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.14643626
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04933827
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.97966597
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79762501
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.73786294
11VDR_24787735_ChIP-Seq_THP-1_Human2.68848618
12GATA1_22025678_ChIP-Seq_K562_Human2.61483925
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.60570735
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53427223
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41528246
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39941792
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.38535039
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.37142650
19TAF15_26573619_Chip-Seq_HEK293_Human2.34015855
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.29050244
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.28441778
22SPI1_23127762_ChIP-Seq_K562_Human2.20173305
23NFE2_27457419_Chip-Seq_LIVER_Mouse2.18347249
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17125895
25* SPI1_23547873_ChIP-Seq_NB4_Human2.16037838
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.14400940
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13016743
28VDR_24763502_ChIP-Seq_THP-1_Human2.10549749
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07233963
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.04337966
31PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04311518
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02966361
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.98253894
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97679757
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.96370141
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.96207012
37P300_19829295_ChIP-Seq_ESCs_Human1.95877369
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.95296533
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.94941015
40SCL_19346495_ChIP-Seq_HPC-7_Human1.91752495
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.91720686
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.91166870
43P53_22387025_ChIP-Seq_ESCs_Mouse1.89642729
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.88455641
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87864364
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87093253
47VDR_21846776_ChIP-Seq_THP-1_Human1.86987592
48IGF1R_20145208_ChIP-Seq_DFB_Human1.83057375
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81659013
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.81566030
51EZH2_22144423_ChIP-Seq_EOC_Human1.78926060
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.78379253
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75117976
54NMYC_18555785_Chip-Seq_ESCs_Mouse1.74481110
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72847868
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.72624131
57PU_27001747_Chip-Seq_BMDM_Mouse1.72290821
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72203442
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71059825
60P300_18555785_Chip-Seq_ESCs_Mouse1.69031987
61RUNX1_27457419_Chip-Seq_LIVER_Mouse1.68265609
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65708566
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64395433
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63747600
65SOX2_18555785_Chip-Seq_ESCs_Mouse1.63511268
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.60539736
67SMAD4_21799915_ChIP-Seq_A2780_Human1.58021780
68FUS_26573619_Chip-Seq_HEK293_Human1.57269232
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57212206
70ZFX_18555785_Chip-Seq_ESCs_Mouse1.56976105
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56664031
72PU1_27457419_Chip-Seq_LIVER_Mouse1.56423147
73ER_23166858_ChIP-Seq_MCF-7_Human1.55040278
74RNF2_27304074_Chip-Seq_NSC_Mouse1.55014549
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.54762354
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.53746432
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52921998
78TFEB_21752829_ChIP-Seq_HELA_Human1.51425398
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50942101
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49396963
81KLF4_18555785_Chip-Seq_ESCs_Mouse1.49330232
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48844350
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.48624481
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46536724
85SMAD1_18555785_Chip-Seq_ESCs_Mouse1.46061749
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43277968
87VDR_22108803_ChIP-Seq_LS180_Human1.42697580
88CTCF_18555785_Chip-Seq_ESCs_Mouse1.41559549
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40087339
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.40079883
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40037979
92EWS_26573619_Chip-Seq_HEK293_Human1.39346454
93LXR_22292898_ChIP-Seq_THP-1_Human1.36804757
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36566256
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35168568
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34061718
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.34000004
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32787854
99MAF_26560356_Chip-Seq_TH1_Human1.32345581
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31691062
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31553550
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31062973
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29446202
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29446202
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.28991870
106RUNX_20019798_ChIP-Seq_JUKART_Human1.28879856
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28676449
108SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28455996
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26730902
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26330688
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.25990692
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25783599
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.25163482
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25031206
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24946036
116STAT3_23295773_ChIP-Seq_U87_Human1.24669873
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.24290194
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24070277
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.22678654
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22339616
121AR_25329375_ChIP-Seq_VCAP_Human1.21494632
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21454923
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.21089316
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20565948
125MYB_26560356_Chip-Seq_TH2_Human1.20355670
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19893180
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18475332
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17242635
129IRF1_19129219_ChIP-ChIP_H3396_Human1.16386014
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16185538
131JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15588735
132TCF4_23295773_ChIP-Seq_U87_Human1.14717563
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14254325
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.12713228
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11690537
136AR_21572438_ChIP-Seq_LNCaP_Human1.11297577
137GATA1_19941826_ChIP-Seq_K562_Human1.11223417
138CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10963768
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10686498
140CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09556527
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09194183
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09037200
143IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07276477
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07010767
145KDM2B_26808549_Chip-Seq_REH_Human1.06682104
146JUN_21703547_ChIP-Seq_K562_Human1.06486434
147P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05812669
148CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05654440
149SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05350415
150FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04486559
151RUNX2_22187159_ChIP-Seq_PCA_Human1.03975346
152EZH2_27304074_Chip-Seq_ESCs_Mouse1.03918055
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03285873
154CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02105118
155GATA2_21666600_ChIP-Seq_HMVEC_Human1.02025608
156STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01883025
157LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01313510
158GATA3_27048872_Chip-Seq_THYMUS_Human0.99335655
159FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96367522
160MYC_22102868_ChIP-Seq_BL_Human0.94753236
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94536793
162STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91887296
163TCF7_22412390_ChIP-Seq_EML_Mouse0.91187919
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91074787
165UTX_26944678_Chip-Seq_JUKART_Human0.91013399
166KDM2B_26808549_Chip-Seq_DND41_Human0.89731041
167CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89528409
168RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89166055
169SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88718703
170JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88080260
171GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86940112
172ESR2_21235772_ChIP-Seq_MCF-7_Human0.86594084
173JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86104532
174GATA3_26560356_Chip-Seq_TH2_Human0.86059987
175ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84770974
176MYB_26560356_Chip-Seq_TH1_Human0.83431927
177GATA2_19941826_ChIP-Seq_K562_Human0.82297720
178CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80383978
179MAF_26560356_Chip-Seq_TH2_Human0.79321251
180BCL6_27268052_Chip-Seq_Bcells_Human0.78681986
181THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78205605
182STAT1_20625510_ChIP-Seq_HELA_Human0.78085533
183KDM2B_26808549_Chip-Seq_K562_Human0.77620049
184UBF1/2_26484160_Chip-Seq_HMECs_Human0.77005185
185GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74751453
186RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74186779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.05512460
2MP0009840_abnormal_foam_cell3.78495899
3MP0003303_peritoneal_inflammation3.69380639
4MP0001188_hyperpigmentation3.53738687
5MP0005646_abnormal_pituitary_gland3.34801416
6MP0002139_abnormal_hepatobiliary_system3.29372350
7MP0000604_amyloidosis3.27745672
8MP0006292_abnormal_olfactory_placode3.19511596
9MP0003172_abnormal_lysosome_physiology3.07069268
10MP0000015_abnormal_ear_pigmentation3.04913207
11MP0003136_yellow_coat_color2.95498442
12MP0003787_abnormal_imprinting2.91873264
13MP0003191_abnormal_cellular_cholesterol2.88369790
14MP0010386_abnormal_urinary_bladder2.87922289
15MP0000343_altered_response_to2.63924449
16MP0000569_abnormal_digit_pigmentation2.62513212
17MP0009278_abnormal_bone_marrow2.62189381
18MP0005645_abnormal_hypothalamus_physiol2.55189762
19MP0002277_abnormal_respiratory_mucosa2.53439275
20MP0001835_abnormal_antigen_presentation2.40160434
21MP0005171_absent_coat_pigmentation2.38170873
22MP0003329_amyloid_beta_deposits2.30649833
23MP0005174_abnormal_tail_pigmentation2.26117466
24MP0003195_calcinosis2.18648495
25MP0003300_gastrointestinal_ulcer2.09646866
26MP0001853_heart_inflammation2.07548636
27MP0003075_altered_response_to2.05993670
28MP0001986_abnormal_taste_sensitivity2.04452544
29MP0001984_abnormal_olfaction2.04401059
30MP0009697_abnormal_copulation2.03655197
31MP0005167_abnormal_blood-brain_barrier2.00444365
32MP0002876_abnormal_thyroid_physiology1.97225386
33MP0002877_abnormal_melanocyte_morpholog1.96067511
34MP0002132_abnormal_respiratory_system1.96040782
35MP0009785_altered_susceptibility_to1.93597325
36MP0002638_abnormal_pupillary_reflex1.93475037
37MP0001533_abnormal_skeleton_physiology1.92130455
38MP0005397_hematopoietic_system_phenotyp1.90637345
39MP0001545_abnormal_hematopoietic_system1.90637345
40MP0005387_immune_system_phenotype1.87890279
41MP0001790_abnormal_immune_system1.87890279
42MP0002148_abnormal_hypersensitivity_rea1.83015204
43MP0003806_abnormal_nucleotide_metabolis1.81914648
44MP0002419_abnormal_innate_immunity1.80223876
45MP0002736_abnormal_nociception_after1.70992369
46MP0003724_increased_susceptibility_to1.69469759
47MP0005379_endocrine/exocrine_gland_phen1.66751679
48MP0008260_abnormal_autophagy1.65021829
49MP0005671_abnormal_response_to1.59545625
50MP0004782_abnormal_surfactant_physiolog1.56786600
51MP0000372_irregular_coat_pigmentation1.55892806
52MP0009333_abnormal_splenocyte_physiolog1.54205600
53MP0004947_skin_inflammation1.54158185
54MP0000566_synostosis1.53096062
55MP0003656_abnormal_erythrocyte_physiolo1.47592507
56MP0005166_decreased_susceptibility_to1.47401448
57MP0002102_abnormal_ear_morphology1.46842595
58MP0005025_abnormal_response_to1.46722494
59MP0003453_abnormal_keratinocyte_physiol1.45069464
60MP0001502_abnormal_circadian_rhythm1.40666768
61MP0002095_abnormal_skin_pigmentation1.39401521
62MP0004742_abnormal_vestibular_system1.38625172
63MP0000920_abnormal_myelination1.38279839
64MP0002735_abnormal_chemical_nociception1.36496658
65MP0008469_abnormal_protein_level1.36348256
66MP0003448_altered_tumor_morphology1.35958804
67MP0003183_abnormal_peptide_metabolism1.35521998
68MP0002452_abnormal_antigen_presenting1.35480073
69MP0003690_abnormal_glial_cell1.35322687
70MP0006082_CNS_inflammation1.30258231
71MP0005409_darkened_coat_color1.28565028
72MP0002837_dystrophic_cardiac_calcinosis1.28183311
73MP0005000_abnormal_immune_tolerance1.28002416
74MP0001968_abnormal_touch/_nociception1.24662807
75MP0001486_abnormal_startle_reflex1.24552059
76MP0002723_abnormal_immune_serum1.22404212
77MP0001800_abnormal_humoral_immune1.21272076
78MP0005365_abnormal_bile_salt1.20435661
79MP0001819_abnormal_immune_cell1.19739639
80MP0004883_abnormal_blood_vessel1.19387098
81MP0008058_abnormal_DNA_repair1.18081198
82MP0002420_abnormal_adaptive_immunity1.17773864
83MP0003879_abnormal_hair_cell1.16797045
84MP0000026_abnormal_inner_ear1.16323107
85MP0005310_abnormal_salivary_gland1.13957140
86MP0005551_abnormal_eye_electrophysiolog1.13417374
87MP0008877_abnormal_DNA_methylation1.12517806
88MP0000858_altered_metastatic_potential1.12507282
89MP0004808_abnormal_hematopoietic_stem1.12013795
90MP0005075_abnormal_melanosome_morpholog1.11593300
91MP0004381_abnormal_hair_follicle1.10969388
92MP0010155_abnormal_intestine_physiology1.10458348
93MP0009764_decreased_sensitivity_to1.10239945
94MP0002090_abnormal_vision1.10012415
95MP0005164_abnormal_response_to1.09057375
96MP0009046_muscle_twitch1.07377848
97MP0001727_abnormal_embryo_implantation1.07291724
98MP0009745_abnormal_behavioral_response1.05637093
99MP0003436_decreased_susceptibility_to1.01832704
100MP0002067_abnormal_sensory_capabilities1.01350725
101MP0008789_abnormal_olfactory_epithelium1.00359508
102MP0001963_abnormal_hearing_physiology0.99652810
103MP0003795_abnormal_bone_structure0.98783878
104MP0003091_abnormal_cell_migration0.97642598
105MP0002998_abnormal_bone_remodeling0.95844135
106MP0001186_pigmentation_phenotype0.95451431
107MP0003880_abnormal_central_pattern0.94613046
108MP0000681_abnormal_thyroid_gland0.94334644
109MP0002572_abnormal_emotion/affect_behav0.93772285
110MP0003634_abnormal_glial_cell0.93297567
111MP0002138_abnormal_hepatobiliary_system0.92839941
112MP0005451_abnormal_body_composition0.91906592
113MP0002557_abnormal_social/conspecific_i0.90102115
114MP0005390_skeleton_phenotype0.89761012
115MP0002163_abnormal_gland_morphology0.88693127
116MP0006276_abnormal_autonomic_nervous0.88288610
117MP0002405_respiratory_system_inflammati0.86611622
118MP0009763_increased_sensitivity_to0.86323817
119MP0002254_reproductive_system_inflammat0.86229752
120MP0003763_abnormal_thymus_physiology0.83207197
121MP0005394_taste/olfaction_phenotype0.82198473
122MP0005499_abnormal_olfactory_system0.82198473
123MP0006054_spinal_hemorrhage0.82059892
124MP0003828_pulmonary_edema0.81784337
125MP0008874_decreased_physiological_sensi0.81384066
126MP0005165_increased_susceptibility_to0.81284679
127MP0005464_abnormal_platelet_physiology0.80924222
128MP0003279_aneurysm0.79374944
129MP0000631_abnormal_neuroendocrine_gland0.77904642
130MP0004510_myositis0.77500117
131MP0002429_abnormal_blood_cell0.77367024
132MP0000249_abnormal_blood_vessel0.76229974
133MP0009765_abnormal_xenobiotic_induced0.75637489
134MP0001324_abnormal_eye_pigmentation0.75565971
135MP0000371_diluted_coat_color0.75019851
136MP0005253_abnormal_eye_physiology0.74889734
137MP0001542_abnormal_bone_strength0.74846214
138MP0005647_abnormal_sex_gland0.74485335
139MP0002398_abnormal_bone_marrow0.73923166
140MP0005023_abnormal_wound_healing0.73851487
141MP0010307_abnormal_tumor_latency0.73730586
142MP0000716_abnormal_immune_system0.72273549
143MP0005257_abnormal_intraocular_pressure0.71304531
144MP0001845_abnormal_inflammatory_respons0.71128788
145MP0000538_abnormal_urinary_bladder0.70424316
146MP0000685_abnormal_immune_system0.70270749
147MP0002896_abnormal_bone_mineralization0.68715195
148MP0000490_abnormal_crypts_of0.68519568
149MP0004142_abnormal_muscle_tone0.67988601
150MP0002933_joint_inflammation0.67359937
151MP0005319_abnormal_enzyme/_coenzyme0.67119879
152MP0008004_abnormal_stomach_pH0.66473448
153MP0001849_ear_inflammation0.66212028
154MP0001501_abnormal_sleep_pattern0.66182204
155MP0000689_abnormal_spleen_morphology0.65985867
156MP0004147_increased_porphyrin_level0.65029634
157MP0000678_abnormal_parathyroid_gland0.64873088
158MP0002064_seizures0.64047121
159MP0001905_abnormal_dopamine_level0.63744943
160MP0003632_abnormal_nervous_system0.61036773
161MP0005595_abnormal_vascular_smooth0.57499564
162MP0002722_abnormal_immune_system0.54879736
163MP0002332_abnormal_exercise_endurance0.54463789

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)9.15624322
2Increased cerebral lipofuscin (HP:0011813)5.55015908
3Increased neuronal autofluorescent lipopigment (HP:0002074)4.76888035
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.68752042
5Dysostosis multiplex (HP:0000943)4.49541566
6Loss of speech (HP:0002371)4.49132138
7Disinhibition (HP:0000734)4.41403850
8Chromsome breakage (HP:0040012)4.25997557
9Metaphyseal irregularity (HP:0003025)4.01762263
10Myocardial infarction (HP:0001658)3.97417123
11Prostate neoplasm (HP:0100787)3.89040640
12Neurofibrillary tangles (HP:0002185)3.73175332
13Febrile seizures (HP:0002373)3.72502299
14Systemic lupus erythematosus (HP:0002725)3.69476217
15Recurrent abscess formation (HP:0002722)3.69274254
16Mutism (HP:0002300)3.67667032
17Abnormal hair whorl (HP:0010721)3.67615554
18Optic neuritis (HP:0100653)3.56318631
19Retrobulbar optic neuritis (HP:0100654)3.56318631
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.51459034
21Abnormality of polysaccharide metabolism (HP:0011012)3.51459034
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.51459034
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.51327639
24Autoimmune thrombocytopenia (HP:0001973)3.42401657
25Hypoplasia of the fovea (HP:0007750)3.38176134
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.38176134
27Mucopolysacchariduria (HP:0008155)3.36443496
28Urinary glycosaminoglycan excretion (HP:0003541)3.36443496
29Diminished motivation (HP:0000745)3.31246870
30Apathy (HP:0000741)3.30902304
31Axonal loss (HP:0003447)3.18309562
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.13776431
33Congenital stationary night blindness (HP:0007642)3.03617132
34Generalized aminoaciduria (HP:0002909)3.02308383
35Thin bony cortex (HP:0002753)2.99033223
36Nuclear cataract (HP:0100018)2.96735764
37Protuberant abdomen (HP:0001538)2.95372440
38Recurrent bacterial skin infections (HP:0005406)2.94161382
39Eczematoid dermatitis (HP:0000976)2.87006926
40Upper motor neuron abnormality (HP:0002127)2.82574159
41Agnosia (HP:0010524)2.80223362
42Chronic hepatic failure (HP:0100626)2.78603690
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77495259
44Obstructive lung disease (HP:0006536)2.75945873
45Chronic obstructive pulmonary disease (HP:0006510)2.75945873
46True hermaphroditism (HP:0010459)2.74336747
47Cerebral inclusion bodies (HP:0100314)2.74180318
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.73705354
49Orchitis (HP:0100796)2.72481958
50Nausea (HP:0002018)2.71635729
51Recurrent gram-negative bacterial infections (HP:0005420)2.70770699
52Abnormality of the fovea (HP:0000493)2.66753476
53Protruding tongue (HP:0010808)2.64479958
54Mediastinal lymphadenopathy (HP:0100721)2.60336566
55Medial flaring of the eyebrow (HP:0010747)2.58603276
56Nephrogenic diabetes insipidus (HP:0009806)2.56083289
57Hepatosplenomegaly (HP:0001433)2.52989577
58Bone pain (HP:0002653)2.51912602
59Enlarged epiphyses (HP:0010580)2.51872509
60Petechiae (HP:0000967)2.46265404
61Osteomalacia (HP:0002749)2.45604177
62Hyperventilation (HP:0002883)2.45102373
63Recurrent cutaneous fungal infections (HP:0011370)2.44385475
64Chronic mucocutaneous candidiasis (HP:0002728)2.44385475
65Inappropriate behavior (HP:0000719)2.44241916
66Pancreatic fibrosis (HP:0100732)2.43776987
67Myositis (HP:0100614)2.43612083
68Recurrent pneumonia (HP:0006532)2.43443837
69Increased serum ferritin (HP:0003281)2.42933782
70Neuronal loss in central nervous system (HP:0002529)2.41921903
71Purpura (HP:0000979)2.40968679
72Xanthomatosis (HP:0000991)2.39856993
73Abnormality of the costochondral junction (HP:0000919)2.39418690
74Abnormality of the prostate (HP:0008775)2.38859384
75White forelock (HP:0002211)2.38524783
76Septo-optic dysplasia (HP:0100842)2.37589915
77Abnormality of the nasal septum (HP:0000419)2.37192457
78Renal cortical cysts (HP:0000803)2.36305737
79Poor head control (HP:0002421)2.35813858
80Tubulointerstitial nephritis (HP:0001970)2.34597569
81Fair hair (HP:0002286)2.30196843
82Prolonged neonatal jaundice (HP:0006579)2.29389249
83Gingivitis (HP:0000230)2.28006912
84Symptomatic seizures (HP:0011145)2.27581103
85Progressive neurologic deterioration (HP:0002344)2.25730816
86Meningitis (HP:0001287)2.24812192
87Hypophosphatemia (HP:0002148)2.24687659
88Congenital primary aphakia (HP:0007707)2.24276652
89Epileptic encephalopathy (HP:0200134)2.24094622
90Abnormality of the periventricular white matter (HP:0002518)2.23343149
91Pathologic fracture (HP:0002756)2.22823931
92Patchy hypopigmentation of hair (HP:0011365)2.22208107
93Hypothermia (HP:0002045)2.22059726
94Submucous cleft hard palate (HP:0000176)2.22013494
95Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20887689
96Dementia (HP:0000726)2.18461059
97Flat occiput (HP:0005469)2.17799089
98Asymmetric septal hypertrophy (HP:0001670)2.17791356
99Focal motor seizures (HP:0011153)2.16150518
100Clubbing of toes (HP:0100760)2.15995769
101Stomatitis (HP:0010280)2.15364109
102Congenital sensorineural hearing impairment (HP:0008527)2.14298129
103Hematochezia (HP:0002573)2.14149976
104Thoracic kyphosis (HP:0002942)2.13869079
105Gait imbalance (HP:0002141)2.13587090
106Delayed epiphyseal ossification (HP:0002663)2.13397001
107Prolonged bleeding time (HP:0003010)2.12473340
108Abnormality of DNA repair (HP:0003254)2.10808260
109Aplasia/Hypoplasia of the uvula (HP:0010293)2.10120092
110Personality changes (HP:0000751)2.07555808
111Albinism (HP:0001022)2.07311971
112Vacuolated lymphocytes (HP:0001922)2.07238624
113Abnormal trabecular bone morphology (HP:0100671)2.06598194
114Interstitial pulmonary disease (HP:0006530)2.05479630
115Abnormality of the renal collecting system (HP:0004742)2.05040632
116Recurrent skin infections (HP:0001581)2.04804852
117Aplasia/Hypoplasia of the macula (HP:0008059)2.02600224
118Generalized hypopigmentation of hair (HP:0011358)2.02035461
119Premature loss of primary teeth (HP:0006323)2.01963126
120Microvesicular hepatic steatosis (HP:0001414)2.01329792
121Amaurosis fugax (HP:0100576)2.00959856
122Poor coordination (HP:0002370)2.00640782
123Optic nerve hypoplasia (HP:0000609)1.99613987
124Joint hemorrhage (HP:0005261)1.99610809
125Abnormality of macrophages (HP:0004311)1.99556021
126Congenital hepatic fibrosis (HP:0002612)1.99124987
127Amyloidosis (HP:0011034)1.98293040
128Abnormality of the preputium (HP:0100587)1.98121295
129Conjugated hyperbilirubinemia (HP:0002908)1.97719468
130Paralysis (HP:0003470)1.96768030
131Alveolar cell carcinoma (HP:0006519)1.95791983
132Pancreatic cysts (HP:0001737)1.94737675
133Cardiomegaly (HP:0001640)1.94366460
134Recurrent fungal infections (HP:0002841)1.94262770
135Abnormality of incisor morphology (HP:0011063)1.93490828
136Abnormality of the lumbar spine (HP:0100712)1.92947857
137Type I transferrin isoform profile (HP:0003642)1.91523586
138Duplicated collecting system (HP:0000081)1.91452908
139Decreased circulating renin level (HP:0003351)1.91290640
140Segmental peripheral demyelination/remyelination (HP:0003481)1.90837892
141Increased CSF protein (HP:0002922)1.90484737
142Peripheral demyelination (HP:0011096)1.89577267
143Upper limb muscle weakness (HP:0003484)1.88961408
144Cheilitis (HP:0100825)1.88710512
145Abnormality of the renal cortex (HP:0011035)1.87771312
146J-shaped sella turcica (HP:0002680)1.87277967
147Blue irides (HP:0000635)1.87149374
148Keratoconjunctivitis sicca (HP:0001097)1.86761892
149Aplasia cutis congenita (HP:0001057)1.86699428
150Retinal atrophy (HP:0001105)1.86591474
151Glomerulonephritis (HP:0000099)1.85966750
152Supranuclear gaze palsy (HP:0000605)1.85712699
153T lymphocytopenia (HP:0005403)1.84971170
154Elevated alkaline phosphatase (HP:0003155)1.84858337
155Abnormality of iron homeostasis (HP:0011031)1.83028154
156Absent/shortened dynein arms (HP:0200106)1.82690673
157Dynein arm defect of respiratory motile cilia (HP:0012255)1.82690673
158Type 2 muscle fiber atrophy (HP:0003554)1.82460286
159Neoplasm of head and neck (HP:0012288)1.81635361
160Esophageal neoplasm (HP:0100751)1.81635361
161Recurrent lower respiratory tract infections (HP:0002783)1.81086157
162Male pseudohermaphroditism (HP:0000037)1.80813696
163Femoral bowing (HP:0002980)1.80657433
164Meckel diverticulum (HP:0002245)1.80610441
165Progressive visual loss (HP:0000529)1.79330600
166Abnormality of the ileum (HP:0001549)1.78492688
167Tetraparesis (HP:0002273)1.78249534
168Encephalitis (HP:0002383)1.77963074
169Global brain atrophy (HP:0002283)1.77271971
170Abnormal delayed hypersensitivity skin test (HP:0002963)1.76961601
171Multiple enchondromatosis (HP:0005701)1.76788231
172Basal ganglia calcification (HP:0002135)1.76483940
173Abnormality of the columella (HP:0009929)1.75737417
174Widely patent fontanelles and sutures (HP:0004492)1.75506501
175Hyperparathyroidism (HP:0000843)1.75470781
176Median cleft lip (HP:0000161)1.74500921
177Bile duct proliferation (HP:0001408)1.74474404
178Abnormal biliary tract physiology (HP:0012439)1.74474404
179Keratoconjunctivitis (HP:0001096)1.73027182
180Abnormality of male internal genitalia (HP:0000022)1.72268679
181Abnormality of chromosome stability (HP:0003220)1.70741115
182Neoplasm of the tracheobronchial system (HP:0100552)1.70317865
183Abnormality of glycolipid metabolism (HP:0010969)1.70065218
184Abnormality of glycosphingolipid metabolism (HP:0004343)1.70065218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.73497664
2NME24.05191028
3PRPF4B2.69106492
4TXK2.62487578
5SIK32.50045554
6ZAK2.46585367
7IRAK42.44133212
8CAMK1D2.42811365
9MAP3K142.37836768
10CAMKK22.31816143
11AKT32.25537951
12CSK2.24148622
13FGR2.19461532
14DDR22.17590868
15NEK92.16092169
16STK162.10702540
17IRAK32.07307535
18BMPR1B2.06166518
19NUAK12.04506464
20YES12.00856231
21MAP2K72.00034688
22SGK21.95083111
23INSRR1.91044718
24ERBB31.86872933
25ADRBK21.84063790
26MATK1.81562294
27MAP3K131.71800618
28MAP3K31.70820223
29BMPR21.69552324
30GRK11.67365154
31MAP3K111.66790854
32LIMK11.64785536
33TGFBR21.63076872
34MOS1.62357784
35CAMK1G1.61588822
36TNIK1.60117731
37CDK31.59325267
38ZAP701.56356004
39RIPK41.55274915
40TAOK31.55266082
41MAP2K31.53868419
42TAOK21.53849613
43EIF2AK21.51923269
44ACVR1B1.51214983
45TEC1.48105399
46MKNK21.45845909
47ABL21.38620015
48TAOK11.37545249
49CDC42BPA1.35309415
50STK38L1.30987096
51CDK81.29181857
52NEK61.27262303
53MAPK131.26738839
54MUSK1.23831392
55ARAF1.22201689
56VRK11.19908135
57PDK21.15435673
58TESK21.15082080
59IKBKB1.13139745
60IKBKE1.11818973
61SGK4941.11340628
62SGK2231.11340628
63SGK31.08032897
64KIT1.06882541
65MAP3K51.04767412
66MAP4K11.04555676
67PLK21.04412928
68MAP3K121.02257474
69FRK0.99684931
70NTRK30.99242889
71BLK0.98451877
72TTN0.91550322
73BRD40.90917477
74PRKCE0.90862771
75PBK0.89146092
76PAK40.84529360
77MAP3K10.81721204
78CHUK0.81231524
79CCNB10.80795995
80JAK30.80221474
81GRK70.80191315
82MKNK10.79820452
83CSF1R0.79247788
84TNK20.76753518
85IRAK20.76631705
86IRAK10.76100586
87SRPK10.73359546
88MAP3K90.71888240
89TRPM70.71815819
90PLK40.71542077
91MAPK150.71470590
92RPS6KA20.71372399
93ICK0.67702710
94RIPK10.67658939
95KSR20.67488563
96PDPK10.66995411
97RPS6KL10.62628701
98RPS6KC10.62628701
99ERN10.61266311
100ERBB40.60982777
101MAPK70.60353909
102SYK0.59848943
103MAP3K80.59811641
104JAK20.59496996
105LYN0.58471814
106MAPK40.58394307
107PDK10.58191922
108PIK3CA0.57037862
109MAP2K60.55669742
110RPS6KB10.53930870
111CLK10.53365865
112CDK60.53207379
113BTK0.53141158
114WNK30.53061959
115STK100.52925398
116DAPK20.52642267
117EPHA40.52495449
118PKN10.52396400
119CAMKK10.52242148
120CDK90.51223979
121RPS6KA40.51218216
122PIK3CG0.49367297
123RPS6KA60.49350375
124MAPK120.48478136
125PIM20.47725619
126MST40.46986908
127SGK10.46751370
128PINK10.45408679
129FES0.43853713
130PRKG20.43235641
131PRKG10.42866445
132MARK30.42254557
133ABL10.41382949
134HCK0.40778426
135BRAF0.39657765
136TBK10.39249381
137BMX0.38868162
138STK240.37271200
139PDGFRB0.36872749
140TYK20.36024159
141LCK0.36007785
142PRKCD0.35142715
143PASK0.34771587
144BCR0.34755886
145PIM10.34617669
146PLK30.33986139
147DYRK1A0.32956304
148INSR0.32366413
149CAMK40.32237169
150TYRO30.31652749
151JAK10.30855300
152CAMK2A0.30675795
153MAP3K40.30653101
154CSNK1A10.30496764
155KSR10.29715653
156TIE10.29600479
157EGFR0.28318044
158FYN0.27663622
159RAF10.27585249
160GSK3A0.27418434
161ATR0.26887089
162PKN20.26574420
163PDGFRA0.25152821
164TESK10.25019196
165RPS6KA10.22563247

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.96997516
2Collecting duct acid secretion_Homo sapiens_hsa049662.56758213
3Nicotine addiction_Homo sapiens_hsa050332.43228936
4Rheumatoid arthritis_Homo sapiens_hsa053232.34153273
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25402463
6Fanconi anemia pathway_Homo sapiens_hsa034602.15042715
7SNARE interactions in vesicular transport_Homo sapiens_hsa041301.99527760
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99091013
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96933621
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.96748500
11Phagosome_Homo sapiens_hsa041451.94870257
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94188784
13Other glycan degradation_Homo sapiens_hsa005111.91237894
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78229568
15Sphingolipid metabolism_Homo sapiens_hsa006001.70104892
16Hematopoietic cell lineage_Homo sapiens_hsa046401.68163414
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.68012246
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59595215
19Graft-versus-host disease_Homo sapiens_hsa053321.59411215
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59155771
21Leishmaniasis_Homo sapiens_hsa051401.58837762
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55220825
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55166578
24Morphine addiction_Homo sapiens_hsa050321.52435914
25Measles_Homo sapiens_hsa051621.49346567
26Primary immunodeficiency_Homo sapiens_hsa053401.47882796
27Synaptic vesicle cycle_Homo sapiens_hsa047211.47371857
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47109025
29Asthma_Homo sapiens_hsa053101.46153064
30Phototransduction_Homo sapiens_hsa047441.43058771
31Taste transduction_Homo sapiens_hsa047421.42312322
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.42178837
33Homologous recombination_Homo sapiens_hsa034401.41167229
34Olfactory transduction_Homo sapiens_hsa047401.41087982
35Non-homologous end-joining_Homo sapiens_hsa034501.37570367
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32968004
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32102499
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31898833
39Allograft rejection_Homo sapiens_hsa053301.31498482
40Autoimmune thyroid disease_Homo sapiens_hsa053201.29679247
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28386412
42Tuberculosis_Homo sapiens_hsa051521.28368264
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27938989
44Serotonergic synapse_Homo sapiens_hsa047261.21447738
45B cell receptor signaling pathway_Homo sapiens_hsa046621.19319244
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18643052
47Bladder cancer_Homo sapiens_hsa052191.15113586
48Antigen processing and presentation_Homo sapiens_hsa046121.14715683
49Sulfur metabolism_Homo sapiens_hsa009201.12466061
50Vibrio cholerae infection_Homo sapiens_hsa051101.11277592
51Malaria_Homo sapiens_hsa051441.05881230
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.05706919
53Osteoclast differentiation_Homo sapiens_hsa043801.04709923
54Influenza A_Homo sapiens_hsa051641.03393677
55Lysosome_Homo sapiens_hsa041421.01856932
56Herpes simplex infection_Homo sapiens_hsa051681.01614297
57Protein export_Homo sapiens_hsa030601.01295748
58Galactose metabolism_Homo sapiens_hsa000520.98884272
59Viral myocarditis_Homo sapiens_hsa054160.96762640
60Type I diabetes mellitus_Homo sapiens_hsa049400.96714971
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96232056
62PPAR signaling pathway_Homo sapiens_hsa033200.95309600
63Regulation of autophagy_Homo sapiens_hsa041400.94258601
64Prion diseases_Homo sapiens_hsa050200.89122896
65Shigellosis_Homo sapiens_hsa051310.86780752
66Fructose and mannose metabolism_Homo sapiens_hsa000510.84209383
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.83745277
68Circadian rhythm_Homo sapiens_hsa047100.82196109
69Chemokine signaling pathway_Homo sapiens_hsa040620.81587583
70Staphylococcus aureus infection_Homo sapiens_hsa051500.79760214
71Arachidonic acid metabolism_Homo sapiens_hsa005900.79592024
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79470273
73Basal transcription factors_Homo sapiens_hsa030220.78368748
74Legionellosis_Homo sapiens_hsa051340.77995085
75Amoebiasis_Homo sapiens_hsa051460.76527163
76Mineral absorption_Homo sapiens_hsa049780.75729419
77TNF signaling pathway_Homo sapiens_hsa046680.75719496
78Pentose phosphate pathway_Homo sapiens_hsa000300.75388240
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74874117
80GABAergic synapse_Homo sapiens_hsa047270.74810975
81Pertussis_Homo sapiens_hsa051330.74729074
82Circadian entrainment_Homo sapiens_hsa047130.72794666
83Base excision repair_Homo sapiens_hsa034100.71599944
84Calcium signaling pathway_Homo sapiens_hsa040200.68606324
85Complement and coagulation cascades_Homo sapiens_hsa046100.67746094
86Acute myeloid leukemia_Homo sapiens_hsa052210.67186401
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.66861090
88African trypanosomiasis_Homo sapiens_hsa051430.66445708
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66148450
90Steroid biosynthesis_Homo sapiens_hsa001000.64589589
91Glutamatergic synapse_Homo sapiens_hsa047240.64534519
92Vitamin digestion and absorption_Homo sapiens_hsa049770.63360518
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62785231
94Insulin secretion_Homo sapiens_hsa049110.61123296
95Purine metabolism_Homo sapiens_hsa002300.58832264
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58141011
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.57578802
98Ovarian steroidogenesis_Homo sapiens_hsa049130.57011436
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.55256709
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.55256222
101Salmonella infection_Homo sapiens_hsa051320.53879639
102VEGF signaling pathway_Homo sapiens_hsa043700.53110547
103T cell receptor signaling pathway_Homo sapiens_hsa046600.52565373
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52329951
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51816539
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51252468
107Ether lipid metabolism_Homo sapiens_hsa005650.51125152
108RNA polymerase_Homo sapiens_hsa030200.51085126
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.49191650
110Hepatitis C_Homo sapiens_hsa051600.47891196
111Platelet activation_Homo sapiens_hsa046110.46817498
112Type II diabetes mellitus_Homo sapiens_hsa049300.46546524
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45868081
114Retinol metabolism_Homo sapiens_hsa008300.44080963
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43608469
116ABC transporters_Homo sapiens_hsa020100.43535192
117Cholinergic synapse_Homo sapiens_hsa047250.43112751
118Hepatitis B_Homo sapiens_hsa051610.42948067
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.42824528
120HIF-1 signaling pathway_Homo sapiens_hsa040660.41229165
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41208034
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40498495
123RNA degradation_Homo sapiens_hsa030180.39428798
124Notch signaling pathway_Homo sapiens_hsa043300.39025013
125Epstein-Barr virus infection_Homo sapiens_hsa051690.38939937
126Prolactin signaling pathway_Homo sapiens_hsa049170.38057547
127Vitamin B6 metabolism_Homo sapiens_hsa007500.37427392
128beta-Alanine metabolism_Homo sapiens_hsa004100.36569491
129Pyrimidine metabolism_Homo sapiens_hsa002400.35318300
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34918118
131cAMP signaling pathway_Homo sapiens_hsa040240.33612533
132GnRH signaling pathway_Homo sapiens_hsa049120.32437802
133Inositol phosphate metabolism_Homo sapiens_hsa005620.31932894
134Melanoma_Homo sapiens_hsa052180.31591833
135Apoptosis_Homo sapiens_hsa042100.31540341
136Toxoplasmosis_Homo sapiens_hsa051450.31372037
137Glutathione metabolism_Homo sapiens_hsa004800.29669403
138Renin-angiotensin system_Homo sapiens_hsa046140.23973376
139Renal cell carcinoma_Homo sapiens_hsa052110.22344736
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22291122
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20971762
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20473943
143Pancreatic cancer_Homo sapiens_hsa052120.20419771
144HTLV-I infection_Homo sapiens_hsa051660.19057067
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.18653266
146Endocytosis_Homo sapiens_hsa041440.18523212
147Chronic myeloid leukemia_Homo sapiens_hsa052200.16470605
148Viral carcinogenesis_Homo sapiens_hsa052030.15464411

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »