ODC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.86614443
2nuclear pore complex assembly (GO:0051292)4.80271313
3ribosomal small subunit biogenesis (GO:0042274)4.79761369
4viral transcription (GO:0019083)4.73803716
5translational termination (GO:0006415)4.67795137
6ribosome assembly (GO:0042255)4.40868301
7metaphase plate congression (GO:0051310)4.39159541
8nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.26638578
9mitotic nuclear envelope disassembly (GO:0007077)4.10883870
10ribosomal small subunit assembly (GO:0000028)4.08087987
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.04642191
12translational elongation (GO:0006414)3.98126749
13cotranslational protein targeting to membrane (GO:0006613)3.98032138
14regulation of fever generation (GO:0031620)3.95645599
15membrane disassembly (GO:0030397)3.92841292
16nuclear envelope disassembly (GO:0051081)3.92841292
17protein targeting to ER (GO:0045047)3.91886020
18positive regulation of heat generation (GO:0031652)3.85933866
19protein localization to kinetochore (GO:0034501)3.84809089
20establishment of integrated proviral latency (GO:0075713)3.83053259
21cellular protein complex disassembly (GO:0043624)3.82344711
22pore complex assembly (GO:0046931)3.82052266
23nucleobase biosynthetic process (GO:0046112)3.81315165
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81087931
25mitotic metaphase plate congression (GO:0007080)3.80726891
26positive regulation of prostaglandin secretion (GO:0032308)3.80498898
27viral life cycle (GO:0019058)3.79367226
28formation of translation preinitiation complex (GO:0001731)3.78145875
29folic acid-containing compound biosynthetic process (GO:0009396)3.76102541
30pre-miRNA processing (GO:0031054)3.75429052
31embryonic process involved in female pregnancy (GO:0060136)3.69039899
32DNA topological change (GO:0006265)3.64051174
33protein complex disassembly (GO:0043241)3.63286032
34folic acid metabolic process (GO:0046655)3.62950408
35protein localization to endoplasmic reticulum (GO:0070972)3.61205042
36regulation of spindle organization (GO:0090224)3.53969037
37regulation of translational termination (GO:0006449)3.53146791
38purine nucleobase biosynthetic process (GO:0009113)3.52442029
39establishment of chromosome localization (GO:0051303)3.49440061
40histone H2A monoubiquitination (GO:0035518)3.49383304
41macromolecular complex disassembly (GO:0032984)3.48509259
42regulation of prostaglandin secretion (GO:0032306)3.46827764
43trophectodermal cell differentiation (GO:0001829)3.46790334
44protein localization to chromosome, centromeric region (GO:0071459)3.46154483
45regulation of RNA export from nucleus (GO:0046831)3.37622296
46telomere maintenance via semi-conservative replication (GO:0032201)3.37285046
47mammary gland epithelial cell proliferation (GO:0033598)3.34762729
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34462488
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.32028388
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29366735
51DNA unwinding involved in DNA replication (GO:0006268)3.27983667
52interferon-gamma secretion (GO:0072643)3.26609141
53maturation of SSU-rRNA (GO:0030490)3.25502896
54positive regulation of bone resorption (GO:0045780)3.23871691
55positive regulation of bone remodeling (GO:0046852)3.23871691
56DNA replication-dependent nucleosome assembly (GO:0006335)3.23568410
57DNA replication-dependent nucleosome organization (GO:0034723)3.23568410
58ribosome biogenesis (GO:0042254)3.21693529
59regulation of gene silencing by RNA (GO:0060966)3.19647425
60regulation of posttranscriptional gene silencing (GO:0060147)3.19647425
61regulation of gene silencing by miRNA (GO:0060964)3.19647425
62DNA replication initiation (GO:0006270)3.18687684
63nuclear envelope organization (GO:0006998)3.18563051
64chromosome condensation (GO:0030261)3.16653527
65CENP-A containing nucleosome assembly (GO:0034080)3.12392794
66chromatin remodeling at centromere (GO:0031055)3.12187556
67positive regulation of chromosome segregation (GO:0051984)3.09505250
68nuclear-transcribed mRNA catabolic process (GO:0000956)3.07474348
69IMP biosynthetic process (GO:0006188)3.06757844
70spliceosomal tri-snRNP complex assembly (GO:0000244)3.05867767
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03246202
72establishment of viral latency (GO:0019043)2.98191722
73nucleobase-containing small molecule interconversion (GO:0015949)2.95303784
74protein targeting to membrane (GO:0006612)2.95033309
75mRNA catabolic process (GO:0006402)2.93630741
76regulation of mitotic spindle organization (GO:0060236)2.92287065
77DNA replication checkpoint (GO:0000076)2.90715798
78positive regulation of icosanoid secretion (GO:0032305)2.87539074
79tolerance induction (GO:0002507)2.87038668
80mitotic recombination (GO:0006312)2.85319319
81ATP-dependent chromatin remodeling (GO:0043044)2.84972551
82telomere maintenance via recombination (GO:0000722)2.84545036
83negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.83808771
84DNA packaging (GO:0006323)2.81010356
85regulation of heat generation (GO:0031650)2.80904354
86NIK/NF-kappaB signaling (GO:0038061)2.80041364
87translation (GO:0006412)2.79137054
88negative regulation of histone methylation (GO:0031061)2.78615320
89heterochromatin organization (GO:0070828)2.78396819
90DNA ligation (GO:0006266)2.78365945
91ribonucleoprotein complex biogenesis (GO:0022613)2.77151428
92negative regulation of RNA splicing (GO:0033119)2.76573926
93paraxial mesoderm development (GO:0048339)2.75676538
94RNA catabolic process (GO:0006401)2.75155110
95mitotic chromosome condensation (GO:0007076)2.74398156
96regulation of translational fidelity (GO:0006450)2.73615184
97ribosomal large subunit biogenesis (GO:0042273)2.72501328
98DNA conformation change (GO:0071103)2.70670513
99mRNA splicing, via spliceosome (GO:0000398)2.70668049
100RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70668049
101chromosome segregation (GO:0007059)2.69915476
102DNA duplex unwinding (GO:0032508)2.69751865
103translational initiation (GO:0006413)2.69164456
104DNA geometric change (GO:0032392)2.67951552
105IMP metabolic process (GO:0046040)2.67794561
106RNA splicing, via transesterification reactions (GO:0000375)2.67394227
107kinetochore organization (GO:0051383)2.66811226
108histone H2B ubiquitination (GO:0033523)2.66313752
109mitotic sister chromatid segregation (GO:0000070)2.65953736
110negative regulation of translational initiation (GO:0045947)2.65692697
111nucleosome disassembly (GO:0006337)2.65340739
112protein-DNA complex disassembly (GO:0032986)2.65340739
113DNA synthesis involved in DNA repair (GO:0000731)2.65040971
114protein localization to chromosome (GO:0034502)2.63093051
115mitochondrial fusion (GO:0008053)2.63019540
116protein K6-linked ubiquitination (GO:0085020)2.61098150
117RNA stabilization (GO:0043489)2.60973619
118mRNA stabilization (GO:0048255)2.60973619
119mitotic sister chromatid cohesion (GO:0007064)2.59811716
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.59538579
121chromatin assembly (GO:0031497)2.59098750
122interferon-gamma production (GO:0032609)2.58396184
123DNA strand elongation involved in DNA replication (GO:0006271)2.58078562
1243-UTR-mediated mRNA stabilization (GO:0070935)2.57619366
125sister chromatid segregation (GO:0000819)2.56890100
126regulation of histone H3-K9 methylation (GO:0051570)2.55107509
127rRNA processing (GO:0006364)2.54236800
128chaperone-mediated protein complex assembly (GO:0051131)2.53963555
129regulation of memory T cell differentiation (GO:0043380)2.53492950
130monoubiquitinated protein deubiquitination (GO:0035520)2.52082036
131regulation of nucleobase-containing compound transport (GO:0032239)2.51941070
132dosage compensation (GO:0007549)2.50872080
133positive regulation of SMAD protein import into nucleus (GO:0060391)2.50275219
134regulation of centrosome cycle (GO:0046605)2.49965401
135histone H2A ubiquitination (GO:0033522)2.49845106
136regulation of chromosome segregation (GO:0051983)2.49609347
137rRNA metabolic process (GO:0016072)2.49246014
138nodal signaling pathway (GO:0038092)2.48736834
139regulation of sister chromatid cohesion (GO:0007063)2.46529698
140chromatin assembly or disassembly (GO:0006333)2.46310232
141DNA replication-independent nucleosome organization (GO:0034724)2.46246913
142DNA replication-independent nucleosome assembly (GO:0006336)2.46246913
143regulation of chromatin binding (GO:0035561)2.45894616
144regulation of translational initiation (GO:0006446)2.42410780
145regulation of translation in response to stress (GO:0043555)2.41540738
146entrainment of circadian clock by photoperiod (GO:0043153)2.41194036
147DNA strand elongation (GO:0022616)2.41146086
148positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.40113531
149positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.40113531
150positive regulation of mitotic sister chromatid separation (GO:1901970)2.40113531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.33152696
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.37813770
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.66228253
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.55158104
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.46338690
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01618366
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00751735
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88556621
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84056609
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77232574
11* MYC_22102868_ChIP-Seq_BL_Human2.66020355
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63147488
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38239011
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32295049
15AR_21909140_ChIP-Seq_LNCAP_Human2.16656511
16ZNF263_19887448_ChIP-Seq_K562_Human2.09345420
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04634993
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03311920
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96871848
20XRN2_22483619_ChIP-Seq_HELA_Human1.93725167
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92753090
22* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81816718
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.78281526
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74912728
25* VDR_23849224_ChIP-Seq_CD4+_Human1.74903520
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70466062
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68177406
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68177406
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68177406
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.65939646
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64488938
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60961926
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59130754
34CLOCK_20551151_ChIP-Seq_293T_Human1.58963104
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55595796
36TTF2_22483619_ChIP-Seq_HELA_Human1.55548049
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.55171316
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52833160
39DCP1A_22483619_ChIP-Seq_HELA_Human1.52185243
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51717507
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51050772
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47025327
43CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.42566330
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.41977581
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41141473
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40064497
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.38703027
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38536286
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36848039
50KDM5A_27292631_Chip-Seq_BREAST_Human1.36081306
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35713211
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.35179891
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35128039
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34014376
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33900272
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32418048
57* ATF3_27146783_Chip-Seq_COLON_Human1.32312954
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31861908
59GABP_19822575_ChIP-Seq_HepG2_Human1.30296853
60VDR_21846776_ChIP-Seq_THP-1_Human1.29853437
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29590685
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29331235
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28413743
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27942575
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27035115
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25768794
67* TCF7_22412390_ChIP-Seq_EML_Mouse1.25527985
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.24669625
69TFEB_21752829_ChIP-Seq_HELA_Human1.24172087
70* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24098508
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23482575
72* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23258561
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22954450
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22830438
75FOXP3_21729870_ChIP-Seq_TREG_Human1.22427103
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20238014
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17564474
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.16040944
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14915530
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13975082
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13777734
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13350749
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12977230
84* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12353634
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11908590
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10736169
87MYB_26560356_Chip-Seq_TH1_Human1.10567049
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10448289
89MAF_26560356_Chip-Seq_TH1_Human1.09848582
90* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09637635
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09577559
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09547862
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08675750
94* SOX17_20123909_ChIP-Seq_XEN_Mouse1.08528475
95ELK1_19687146_ChIP-ChIP_HELA_Human1.08045038
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07906774
97MYB_26560356_Chip-Seq_TH2_Human1.07417252
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05640387
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.05570722
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.05418682
101CIITA_25753668_ChIP-Seq_RAJI_Human1.05390893
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05085621
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04877498
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03617758
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00624510
106* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00583190
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99981000
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.99202345
109* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99158358
110* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96622187
111KDM2B_26808549_Chip-Seq_DND41_Human0.96516266
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96017196
113UTX_26944678_Chip-Seq_JUKART_Human0.94767092
114CHD1_26751641_Chip-Seq_LNCaP_Human0.93439742
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93426083
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92133659
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92130438
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91552044
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91395796
120STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90031169
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89846173
122* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89533990
123MYC_18940864_ChIP-ChIP_HL60_Human0.89468803
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89164503
125* NCOR1_26117541_ChIP-Seq_K562_Human0.89062907
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88967951
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88882322
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84016189
129TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83942183
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82845796
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82751627
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82640687
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81804226
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81443292
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.81032286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.06209221
2MP0004957_abnormal_blastocyst_morpholog3.45603271
3MP0003111_abnormal_nucleus_morphology3.39389913
4MP0010352_gastrointestinal_tract_polyps3.12638120
5MP0003077_abnormal_cell_cycle3.07740037
6MP0010094_abnormal_chromosome_stability3.00542895
7MP0008057_abnormal_DNA_replication2.75065679
8MP0005076_abnormal_cell_differentiation2.70190871
9MP0000566_synostosis2.61147471
10MP0008007_abnormal_cellular_replicative2.53931554
11MP0009379_abnormal_foot_pigmentation2.52032622
12MP0000350_abnormal_cell_proliferation2.16272430
13MP0001730_embryonic_growth_arrest2.11998027
14MP0006292_abnormal_olfactory_placode2.10085913
15MP0010307_abnormal_tumor_latency2.04983033
16MP0008058_abnormal_DNA_repair1.97628713
17MP0003705_abnormal_hypodermis_morpholog1.97036209
18MP0002234_abnormal_pharynx_morphology1.96854488
19MP0009697_abnormal_copulation1.94993475
20MP0003303_peritoneal_inflammation1.92753515
21MP0001672_abnormal_embryogenesis/_devel1.89806443
22MP0005380_embryogenesis_phenotype1.89806443
23MP0003123_paternal_imprinting1.88366614
24MP0002088_abnormal_embryonic_growth/wei1.85124516
25MP0000685_abnormal_immune_system1.84414132
26MP0003984_embryonic_growth_retardation1.82109052
27MP0003315_abnormal_perineum_morphology1.81958004
28MP0000490_abnormal_crypts_of1.77564577
29MP0002086_abnormal_extraembryonic_tissu1.72730648
30MP0001697_abnormal_embryo_size1.71954573
31MP0004264_abnormal_extraembryonic_tissu1.71450791
32MP0002697_abnormal_eye_size1.70115126
33MP0005394_taste/olfaction_phenotype1.62440931
34MP0005499_abnormal_olfactory_system1.62440931
35MP0008789_abnormal_olfactory_epithelium1.60811273
36* MP0008932_abnormal_embryonic_tissue1.58654217
37MP0002084_abnormal_developmental_patter1.57929369
38MP0004197_abnormal_fetal_growth/weight/1.57453053
39MP0001286_abnormal_eye_development1.49710120
40MP0002877_abnormal_melanocyte_morpholog1.49350263
41MP0000579_abnormal_nail_morphology1.48685649
42MP0003937_abnormal_limbs/digits/tail_de1.47477096
43* MP0002080_prenatal_lethality1.43480896
44MP0002085_abnormal_embryonic_tissue1.42430505
45MP0000703_abnormal_thymus_morphology1.40330027
46MP0003763_abnormal_thymus_physiology1.37563184
47MP0003786_premature_aging1.37421590
48MP0004808_abnormal_hematopoietic_stem1.35415206
49MP0001849_ear_inflammation1.34201977
50MP0002405_respiratory_system_inflammati1.33930745
51MP0009333_abnormal_splenocyte_physiolog1.33665472
52MP0001881_abnormal_mammary_gland1.32711128
53MP0000537_abnormal_urethra_morphology1.31986287
54MP0009278_abnormal_bone_marrow1.31411167
55MP0010234_abnormal_vibrissa_follicle1.31265256
56MP0005397_hematopoietic_system_phenotyp1.30822059
57MP0001545_abnormal_hematopoietic_system1.30822059
58MP0003385_abnormal_body_wall1.30674281
59MP0000858_altered_metastatic_potential1.27542142
60MP0002396_abnormal_hematopoietic_system1.25523607
61MP0000762_abnormal_tongue_morphology1.24498962
62MP0005451_abnormal_body_composition1.22975058
63MP0003566_abnormal_cell_adhesion1.22893941
64MP0002277_abnormal_respiratory_mucosa1.21421981
65MP0000733_abnormal_muscle_development1.21033826
66MP0004947_skin_inflammation1.20785057
67MP0003861_abnormal_nervous_system1.20657384
68MP0002233_abnormal_nose_morphology1.20230577
69MP0005501_abnormal_skin_physiology1.19204806
70MP0002138_abnormal_hepatobiliary_system1.18609845
71MP0002722_abnormal_immune_system1.16472329
72MP0009672_abnormal_birth_weight1.15575835
73MP0002398_abnormal_bone_marrow1.15126730
74MP0002019_abnormal_tumor_incidence1.14822098
75MP0000428_abnormal_craniofacial_morphol1.14154207
76MP0002111_abnormal_tail_morphology1.13628493
77MP0004185_abnormal_adipocyte_glucose1.13490727
78MP0001529_abnormal_vocalization1.11906072
79MP0002210_abnormal_sex_determination1.10914243
80MP0001790_abnormal_immune_system1.10892599
81MP0005387_immune_system_phenotype1.10892599
82MP0010155_abnormal_intestine_physiology1.10443621
83MP0003567_abnormal_fetal_cardiomyocyte1.09256412
84MP0000313_abnormal_cell_death1.08641954
85MP0003755_abnormal_palate_morphology1.06786641
86MP0001800_abnormal_humoral_immune1.06365671
87MP0000689_abnormal_spleen_morphology1.06215819
88MP0005187_abnormal_penis_morphology1.05176044
89MP0002009_preneoplasia1.04854849
90MP0004858_abnormal_nervous_system1.04353538
91MP0009053_abnormal_anal_canal1.04255437
92MP0003942_abnormal_urinary_system1.04077312
93MP0001346_abnormal_lacrimal_gland1.01745974
94MP0003300_gastrointestinal_ulcer1.01028626
95MP0003453_abnormal_keratinocyte_physiol1.00656315
96MP0000778_abnormal_nervous_system1.00346190
97MP0000627_abnormal_mammary_gland0.98400934
98MP0003935_abnormal_craniofacial_develop0.95407226
99MP0004233_abnormal_muscle_weight0.94757472
100MP0005621_abnormal_cell_physiology0.94402847
101MP0003448_altered_tumor_morphology0.94066455
102MP0001727_abnormal_embryo_implantation0.93742194
103MP0005023_abnormal_wound_healing0.93284622
104MP0001216_abnormal_epidermal_layer0.92760474
105MP0000358_abnormal_cell_content/0.92637554
106MP0000477_abnormal_intestine_morphology0.92264310
107MP0009703_decreased_birth_body0.91303336
108MP0001929_abnormal_gametogenesis0.90399285
109MP0008260_abnormal_autophagy0.88298374
110MP0003121_genomic_imprinting0.88076330
111MP0002723_abnormal_immune_serum0.87041030
112MP0000467_abnormal_esophagus_morphology0.86849295
113MP0003122_maternal_imprinting0.86141334
114MP0002429_abnormal_blood_cell0.85858492
115MP0001145_abnormal_male_reproductive0.85658552
116MP0008877_abnormal_DNA_methylation0.85317336
117MP0004019_abnormal_vitamin_homeostasis0.85167604
118MP0003866_abnormal_defecation0.85048277
119MP0000716_abnormal_immune_system0.85017702
120MP0003890_abnormal_embryonic-extraembry0.84874806
121MP0000647_abnormal_sebaceous_gland0.84347710
122MP0003941_abnormal_skin_development0.82685616
123MP0005000_abnormal_immune_tolerance0.82496624
124MP0002938_white_spotting0.81344329
125MP0003718_maternal_effect0.81248006
126MP0002089_abnormal_postnatal_growth/wei0.80408423
127MP0000049_abnormal_middle_ear0.79794965
128MP0005377_hearing/vestibular/ear_phenot0.79484481
129MP0003878_abnormal_ear_physiology0.79484481
130MP0002098_abnormal_vibrissa_morphology0.79202290
131MP0005671_abnormal_response_to0.78586427
132MP0002452_abnormal_antigen_presenting0.78189377
133MP0000377_abnormal_hair_follicle0.77507845
134MP0000465_gastrointestinal_hemorrhage0.77312414
135MP0005384_cellular_phenotype0.77166968
136MP0002081_perinatal_lethality0.76938190
137MP0010678_abnormal_skin_adnexa0.75422770
138MP0000653_abnormal_sex_gland0.75397404
139MP0000432_abnormal_head_morphology0.75052824
140MP0009840_abnormal_foam_cell0.74730726
141MP0010030_abnormal_orbit_morphology0.74713090
142MP0002420_abnormal_adaptive_immunity0.74457609
143MP0001293_anophthalmia0.74413934
144MP0006035_abnormal_mitochondrial_morpho0.74082813
145MP0008961_abnormal_basal_metabolism0.74032544
146MP0001819_abnormal_immune_cell0.73371117
147MP0001340_abnormal_eyelid_morphology0.72593269
148MP0005248_abnormal_Harderian_gland0.72432241
149MP0003119_abnormal_digestive_system0.72076272
150MP0003221_abnormal_cardiomyocyte_apopto0.72057393
151MP0002653_abnormal_ependyma_morphology0.70975806
152MP0002092_abnormal_eye_morphology0.69897781
153MP0001873_stomach_inflammation0.69709743

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)7.95765822
2Persistence of primary teeth (HP:0006335)6.52902608
3Retrobulbar optic neuritis (HP:0100654)4.08730229
4Optic neuritis (HP:0100653)4.08730229
5Birth length less than 3rd percentile (HP:0003561)3.67565920
6Orchitis (HP:0100796)3.58796836
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31858019
8Chromsome breakage (HP:0040012)3.10867116
9Premature loss of primary teeth (HP:0006323)2.98302545
10Keratoconjunctivitis sicca (HP:0001097)2.95769176
11Myositis (HP:0100614)2.95663718
12Breast hypoplasia (HP:0003187)2.95103213
13Rhinitis (HP:0012384)2.87555220
14Ependymoma (HP:0002888)2.86640995
15Oral leukoplakia (HP:0002745)2.76546691
16Keratoconjunctivitis (HP:0001096)2.67977724
17High anterior hairline (HP:0009890)2.65451457
1811 pairs of ribs (HP:0000878)2.64738610
19Colon cancer (HP:0003003)2.64122864
20IgM deficiency (HP:0002850)2.62021887
21Impulsivity (HP:0100710)2.61296868
22Rectal prolapse (HP:0002035)2.60659122
23Carpal bone hypoplasia (HP:0001498)2.58830655
24Abnormal tarsal ossification (HP:0008369)2.56551853
25Selective tooth agenesis (HP:0001592)2.54884882
26Microvesicular hepatic steatosis (HP:0001414)2.52226921
27Biliary tract neoplasm (HP:0100574)2.49892095
28Pallor (HP:0000980)2.45813551
29Rough bone trabeculation (HP:0100670)2.45165568
30Rhabdomyosarcoma (HP:0002859)2.44949770
31Cortical dysplasia (HP:0002539)2.43850186
32Reticulocytopenia (HP:0001896)2.42270886
33Increased nuchal translucency (HP:0010880)2.40772674
34Pelvic girdle muscle weakness (HP:0003749)2.35139905
35Duplication of thumb phalanx (HP:0009942)2.33816523
36Metaphyseal cupping (HP:0003021)2.29242953
37Arterial thrombosis (HP:0004420)2.28306689
38Patellar aplasia (HP:0006443)2.25229989
39Deviation of the thumb (HP:0009603)2.24884436
40Pancytopenia (HP:0001876)2.20400422
41Multiple enchondromatosis (HP:0005701)2.20351891
42Abnormality of cells of the erythroid lineage (HP:0012130)2.18958297
43Proximal placement of thumb (HP:0009623)2.18501063
44Abnormal foot bone ossification (HP:0010675)2.18498765
45Aplasia/Hypoplasia of the patella (HP:0006498)2.18467112
46Degeneration of anterior horn cells (HP:0002398)2.16834017
47Abnormality of the anterior horn cell (HP:0006802)2.16834017
48Anorexia (HP:0002039)2.16159430
49Abnormality of the phalanges of the hallux (HP:0010057)2.13513376
50Termporal pattern (HP:0011008)2.12754667
51Insidious onset (HP:0003587)2.12754667
52Abnormality of reticulocytes (HP:0004312)2.12489869
53Abnormality of the preputium (HP:0100587)2.12094508
54Aseptic necrosis (HP:0010885)2.11899281
55Prominent nose (HP:0000448)2.10460020
56Poikiloderma (HP:0001029)2.10241337
57Basal cell carcinoma (HP:0002671)2.08726868
58Trismus (HP:0000211)2.07362411
59Fragile nails (HP:0001808)2.06371414
60Neoplasm of the pancreas (HP:0002894)2.06286279
61Small epiphyses (HP:0010585)2.05986256
62Ureteral duplication (HP:0000073)2.04321598
63Abnormality of the labia minora (HP:0012880)2.04297506
64Meckel diverticulum (HP:0002245)2.04008672
65Entropion (HP:0000621)2.01981827
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.00183152
67Abnormality of the fingertips (HP:0001211)1.98420196
68Esophageal atresia (HP:0002032)1.96925549
69Amaurosis fugax (HP:0100576)1.96356925
70Medulloblastoma (HP:0002885)1.95065648
71Abnormality of glycolysis (HP:0004366)1.94933873
72Facial cleft (HP:0002006)1.94468998
73Absent radius (HP:0003974)1.93742010
74Horseshoe kidney (HP:0000085)1.93527858
75Shoulder girdle muscle weakness (HP:0003547)1.92438480
76Squamous cell carcinoma (HP:0002860)1.92195735
77Abnormality of the ileum (HP:0001549)1.91740625
78Flattened epiphyses (HP:0003071)1.89719233
79Malignant gastrointestinal tract tumors (HP:0006749)1.89291331
80Gastrointestinal carcinoma (HP:0002672)1.89291331
81Abnormal number of erythroid precursors (HP:0012131)1.87993442
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87876428
83Triphalangeal thumb (HP:0001199)1.86245053
84Abnormal trabecular bone morphology (HP:0100671)1.86218820
85Increased serum pyruvate (HP:0003542)1.85838434
86Progressive external ophthalmoplegia (HP:0000590)1.85376343
87Oligodactyly (HP:0012165)1.84504159
88Progressive muscle weakness (HP:0003323)1.83314143
89Aplasia/hypoplasia of the humerus (HP:0006507)1.83044616
90Achilles tendon contracture (HP:0001771)1.82395883
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.81896099
92Abnormality of the distal phalanges of the toes (HP:0010182)1.81465049
93Septate vagina (HP:0001153)1.81159549
94Overlapping toe (HP:0001845)1.80818195
95Deep palmar crease (HP:0006191)1.80788808
96Aplasia involving forearm bones (HP:0009822)1.80277377
97Absent forearm bone (HP:0003953)1.80277377
98Duodenal stenosis (HP:0100867)1.79707962
99Small intestinal stenosis (HP:0012848)1.79707962
100Atresia of the external auditory canal (HP:0000413)1.78866862
101Hypoplastic pelvis (HP:0008839)1.78672176
102Partial duplication of thumb phalanx (HP:0009944)1.78667850
103Abnormality of the hip-girdle musculature (HP:0001445)1.78656308
104Abnormality of the musculature of the pelvis (HP:0001469)1.78656308
105Astrocytoma (HP:0009592)1.78345821
106Abnormality of the astrocytes (HP:0100707)1.78345821
107Hyperacusis (HP:0010780)1.78138529
108Insomnia (HP:0100785)1.78005655
109Ankyloglossia (HP:0010296)1.77981872
110Abnormality of the carotid arteries (HP:0005344)1.76433990
111Neoplasm of striated muscle (HP:0009728)1.76158301
112Agnosia (HP:0010524)1.75665771
113Ridged nail (HP:0001807)1.75163313
114Overriding aorta (HP:0002623)1.74380419
115Macrocytic anemia (HP:0001972)1.72043595
116Upper limb muscle weakness (HP:0003484)1.70577380
117Broad distal phalanx of finger (HP:0009836)1.70164548
118IgA deficiency (HP:0002720)1.69781882
119Facial hemangioma (HP:0000329)1.69658935
120Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69225534
121Abnormality of chromosome stability (HP:0003220)1.69182223
122Absent thumb (HP:0009777)1.68590468
123Leiomyosarcoma (HP:0100243)1.68293838
124Uterine leiomyosarcoma (HP:0002891)1.68293838
125Lymphoma (HP:0002665)1.68276614
126Abnormal biliary tract morphology (HP:0012440)1.67492377
127Onycholysis (HP:0001806)1.67312165
128Difficulty climbing stairs (HP:0003551)1.67297451
129Short thumb (HP:0009778)1.67063185
130Papillary thyroid carcinoma (HP:0002895)1.66874289
131Coarctation of aorta (HP:0001680)1.66086171
132Milia (HP:0001056)1.65828513
133Pulmonary infiltrates (HP:0002113)1.65517670
134Short humerus (HP:0005792)1.65430187
135Abnormality of the Achilles tendon (HP:0005109)1.65122636
136Missing ribs (HP:0000921)1.64998231
137Premature ovarian failure (HP:0008209)1.62415365
138Abnormality of the umbilical cord (HP:0010881)1.62311005
139Sparse lateral eyebrow (HP:0005338)1.62094621
140Glioma (HP:0009733)1.59852857
141Abnormal number of incisors (HP:0011064)1.59831643
142Glossoptosis (HP:0000162)1.59512960
143Abnormality of cochlea (HP:0000375)1.59498361
144Genu recurvatum (HP:0002816)1.59422594
145Oligodactyly (hands) (HP:0001180)1.58485963
146Spinal muscular atrophy (HP:0007269)1.57489422
147Combined immunodeficiency (HP:0005387)1.57064718
148Choanal atresia (HP:0000453)1.55860835
149Hyperglycinuria (HP:0003108)1.55055498
150Partial duplication of the phalanx of hand (HP:0009999)1.53644803
151Pterygium (HP:0001059)1.53457836
152Hypoalbuminemia (HP:0003073)1.52891595
153Abnormal albumin level (HP:0012116)1.52891595
154Spastic diplegia (HP:0001264)1.52616328
155Cafe-au-lait spot (HP:0000957)1.52603047
156Vertebral hypoplasia (HP:0008417)1.51890640
157Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.51890640
158Abnormality of the duodenum (HP:0002246)1.51518997
159Ectopic kidney (HP:0000086)1.51517080
160Gout (HP:0001997)1.50634242
161Unilateral renal agenesis (HP:0000122)1.50325038
162Abnormality of the calcaneus (HP:0008364)1.50276863
163Blepharitis (HP:0000498)1.49996824
164Myelodysplasia (HP:0002863)1.49812295
165Postnatal microcephaly (HP:0005484)1.49110516
166Abnormal lung lobation (HP:0002101)1.48823389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.74691976
2PBK3.14439644
3TAOK32.94548551
4IRAK32.83264065
5CDK122.82205533
6EPHA22.79203662
7WEE12.75769694
8BUB12.75722034
9NEK22.70258164
10EEF2K2.53773510
11CDC72.29230614
12ICK2.15719709
13RPS6KA41.98026563
14PIM11.83581453
15EPHB21.78701249
16SMG11.72618685
17CDK41.70579691
18NME21.69594515
19TTK1.69241620
20STK101.67755423
21TXK1.66674876
22RPS6KB21.64571829
23TRIB31.61633840
24MKNK21.52002946
25EIF2AK11.50219617
26ARAF1.48196396
27ALK1.46496832
28PKN21.44976092
29MAP4K11.43068495
30DYRK31.42820921
31MAP3K81.42394314
32NEK11.39839036
33MAP3K31.36464588
34VRK21.31980202
35MAP2K31.31547361
36BRAF1.29038840
37PNCK1.28073301
38MST1R1.27808909
39STK31.27617027
40LATS11.26835134
41CHUK1.26550309
42CDK81.25314645
43CDK61.23567111
44PLK31.20309568
45KSR11.20111578
46MKNK11.18231280
47MELK1.17134445
48PLK11.16496662
49MAP3K91.16049371
50AURKB1.14624738
51SRPK11.13310715
52GRK61.13262436
53MET1.12777748
54PLK41.11621831
55SCYL21.10637828
56MAP3K101.10237632
57ACVR1B1.07343066
58CDK71.06235362
59PASK1.04865897
60CHEK11.03775607
61MAP3K141.01395369
62PAK41.01363793
63BRSK21.00779976
64IKBKB0.98764209
65KSR20.97299597
66STK160.97015892
67ZAK0.96665841
68BMX0.96646734
69NME10.96187432
70GSK3A0.95400924
71MTOR0.93715008
72CHEK20.93685178
73ITK0.88293346
74SIK10.86605640
75BRSK10.85010395
76BRD40.81997159
77ERBB40.81219728
78TAF10.79434310
79LRRK20.78793614
80AURKA0.78066280
81MARK30.76609571
82RAF10.75872626
83RPS6KA50.75566102
84ATR0.75016900
85VRK10.73836068
86CAMK1D0.73263498
87TGFBR10.72680978
88LATS20.70512231
89AKT20.70313264
90TEC0.70285707
91CDK20.68013342
92MAP3K110.67335007
93RPS6KA10.66491416
94PTK60.66276861
95BCR0.66057650
96MAP2K20.65848740
97STK38L0.63854791
98TAOK10.63589987
99ZAP700.60469482
100FGFR40.60165511
101CLK10.59048297
102BTK0.58415858
103STK240.58101160
104PAK20.58000355
105MOS0.57246050
106PIM20.56308219
107CDK11A0.54916730
108MAP3K50.54861961
109CAMK1G0.54585276
110TESK20.54514277
111EIF2AK30.54082462
112JAK30.53831038
113ATM0.52102895
114TBK10.51378092
115CDK140.49857379
116PDK40.49522429
117PDK30.49522429
118CDK150.48936724
119MAPKAPK30.48725935
120JAK10.47940116
121PRKCI0.47787210
122MST40.47575061
123TLK10.47550016
124CDK180.47038422
125EIF2AK20.46495767
126TAOK20.44957539
127CDK10.44712168
128ILK0.44382657
129DYRK1B0.43337477
130TRIM280.43066870
131CDK90.43061187
132CSNK2A20.42030747
133EPHB10.41604396
134PDGFRA0.41400117
135CSNK1E0.40832799
136STK40.40649538
137RPS6KB10.40594953
138CCNB10.38808641
139MAP2K70.38129671

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46621953
2RNA transport_Homo sapiens_hsa030133.18026432
3Spliceosome_Homo sapiens_hsa030402.79502222
4DNA replication_Homo sapiens_hsa030302.78839887
5Cell cycle_Homo sapiens_hsa041102.46121931
6RNA polymerase_Homo sapiens_hsa030202.36463986
7Mismatch repair_Homo sapiens_hsa034302.27419704
8One carbon pool by folate_Homo sapiens_hsa006702.26100130
9Vitamin B6 metabolism_Homo sapiens_hsa007502.14175830
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10421332
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08827989
12p53 signaling pathway_Homo sapiens_hsa041152.03197599
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.95780616
14mRNA surveillance pathway_Homo sapiens_hsa030151.76036777
15Ribosome_Homo sapiens_hsa030101.74644403
16Nucleotide excision repair_Homo sapiens_hsa034201.64865097
17Base excision repair_Homo sapiens_hsa034101.64183565
18Epstein-Barr virus infection_Homo sapiens_hsa051691.61072771
19Antigen processing and presentation_Homo sapiens_hsa046121.58980046
20Circadian rhythm_Homo sapiens_hsa047101.51575196
21Pyrimidine metabolism_Homo sapiens_hsa002401.48188628
22Small cell lung cancer_Homo sapiens_hsa052221.43101176
23Alcoholism_Homo sapiens_hsa050341.41665278
24Legionellosis_Homo sapiens_hsa051341.35646656
25Osteoclast differentiation_Homo sapiens_hsa043801.35518073
26RNA degradation_Homo sapiens_hsa030181.35402743
27Proteasome_Homo sapiens_hsa030501.34867779
28Viral carcinogenesis_Homo sapiens_hsa052031.34518080
29HTLV-I infection_Homo sapiens_hsa051661.27321337
30Herpes simplex infection_Homo sapiens_hsa051681.24864425
31MicroRNAs in cancer_Homo sapiens_hsa052061.24579423
32Basal transcription factors_Homo sapiens_hsa030221.20394622
33Homologous recombination_Homo sapiens_hsa034401.20103723
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18776030
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18434710
36Steroid biosynthesis_Homo sapiens_hsa001001.16976247
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13720210
38TNF signaling pathway_Homo sapiens_hsa046681.12586474
39Chronic myeloid leukemia_Homo sapiens_hsa052201.11070323
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09437249
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07674867
42Hedgehog signaling pathway_Homo sapiens_hsa043401.06795479
43Protein export_Homo sapiens_hsa030601.05626353
44Fanconi anemia pathway_Homo sapiens_hsa034601.04620074
45T cell receptor signaling pathway_Homo sapiens_hsa046601.03080970
46Apoptosis_Homo sapiens_hsa042101.02702870
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.02418298
48Measles_Homo sapiens_hsa051621.01870842
49Carbon metabolism_Homo sapiens_hsa012000.98771992
50Selenocompound metabolism_Homo sapiens_hsa004500.98482487
51Systemic lupus erythematosus_Homo sapiens_hsa053220.96428685
52Huntingtons disease_Homo sapiens_hsa050160.95322347
53Prolactin signaling pathway_Homo sapiens_hsa049170.95053163
54Acute myeloid leukemia_Homo sapiens_hsa052210.94715411
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91885345
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.91528281
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89620124
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88511703
59Hippo signaling pathway_Homo sapiens_hsa043900.87764414
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87036470
61Pyruvate metabolism_Homo sapiens_hsa006200.84023779
62Hepatitis B_Homo sapiens_hsa051610.82735321
63mTOR signaling pathway_Homo sapiens_hsa041500.82340176
64Thyroid cancer_Homo sapiens_hsa052160.81808678
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80265795
66Non-homologous end-joining_Homo sapiens_hsa034500.79333864
67Wnt signaling pathway_Homo sapiens_hsa043100.77910751
68Bladder cancer_Homo sapiens_hsa052190.76354759
69Toxoplasmosis_Homo sapiens_hsa051450.76197538
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.74988050
71Parkinsons disease_Homo sapiens_hsa050120.74290324
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73569035
73HIF-1 signaling pathway_Homo sapiens_hsa040660.72399822
74Prostate cancer_Homo sapiens_hsa052150.71948073
75B cell receptor signaling pathway_Homo sapiens_hsa046620.69810401
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69007513
77Pentose phosphate pathway_Homo sapiens_hsa000300.68271994
78FoxO signaling pathway_Homo sapiens_hsa040680.67998602
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67972932
80Colorectal cancer_Homo sapiens_hsa052100.67439472
81Oocyte meiosis_Homo sapiens_hsa041140.67348809
82Influenza A_Homo sapiens_hsa051640.66944185
83Biosynthesis of amino acids_Homo sapiens_hsa012300.66916120
84N-Glycan biosynthesis_Homo sapiens_hsa005100.66617019
85Non-small cell lung cancer_Homo sapiens_hsa052230.65991045
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.65289683
87Sulfur relay system_Homo sapiens_hsa041220.64826322
88Fatty acid biosynthesis_Homo sapiens_hsa000610.64635678
89Endometrial cancer_Homo sapiens_hsa052130.64331441
90Shigellosis_Homo sapiens_hsa051310.62791961
91TGF-beta signaling pathway_Homo sapiens_hsa043500.62768199
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62509201
93Folate biosynthesis_Homo sapiens_hsa007900.60325028
94Leishmaniasis_Homo sapiens_hsa051400.60040601
95Primary immunodeficiency_Homo sapiens_hsa053400.57629377
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57535297
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.55187093
98Proteoglycans in cancer_Homo sapiens_hsa052050.54980521
99Renal cell carcinoma_Homo sapiens_hsa052110.54885648
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54722535
101Purine metabolism_Homo sapiens_hsa002300.53791655
102Pancreatic cancer_Homo sapiens_hsa052120.52044889
103Adherens junction_Homo sapiens_hsa045200.52040934
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51678351
105ErbB signaling pathway_Homo sapiens_hsa040120.51647080
106Pathways in cancer_Homo sapiens_hsa052000.50476915
107Basal cell carcinoma_Homo sapiens_hsa052170.50053761
108Oxidative phosphorylation_Homo sapiens_hsa001900.48729933
109Lysine degradation_Homo sapiens_hsa003100.48542171
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.48485924
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.48388784
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48319767
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.48234035
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.48212426
115Notch signaling pathway_Homo sapiens_hsa043300.47262884
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47253158
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46788791
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44743364
119Hematopoietic cell lineage_Homo sapiens_hsa046400.43704350
120Fructose and mannose metabolism_Homo sapiens_hsa000510.42246560
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41577671
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40838540
123VEGF signaling pathway_Homo sapiens_hsa043700.40824536
124Axon guidance_Homo sapiens_hsa043600.38709287
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37438230
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36867696
127Alzheimers disease_Homo sapiens_hsa050100.34515628
128Melanoma_Homo sapiens_hsa052180.34254540
129Fatty acid elongation_Homo sapiens_hsa000620.33970636
130Glioma_Homo sapiens_hsa052140.33685620
131AMPK signaling pathway_Homo sapiens_hsa041520.33595036
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32869483
133* Arginine and proline metabolism_Homo sapiens_hsa003300.32424653
134Melanogenesis_Homo sapiens_hsa049160.32339752
135Insulin signaling pathway_Homo sapiens_hsa049100.30987738

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »